Search

Your search keyword '"Riesmeyer, Jeffrey S."' showing total 43 results
Start Over Author "Riesmeyer, Jeffrey S."
43 results on '"Riesmeyer, Jeffrey S."'

2. Tirzepatide versus insulin glargine in type 2 diabetes and increased cardiovascular risk (SURPASS-4): a randomised, open-label, parallel-group, multicentre, phase 3 trial

Author

Ahmann, Andrew J, Arora, Samir, Ball, Eric M, Calderon, Rafael B, Butuk, David J, Chaychi, Leila, Chen, Michael C, Curtis, Brian M, Chochinov, Ronald, Chow, Christopher, Cone, Clancy L, Connery, Lisa, Cortes-Maisonet, Gregorio A, de Souza, Jose, Dungan, Kathleen, Bradley, David, Frias, Juan P, Gabra, Nashwa, Gaudiani, Linda, Herandez-Vazquez, Luis, Hsia, Stanley H, Jardula, Michael R, Klein, Eric J, Kutner, Mark E, Loy, Juan, Miranda, Francisco G, Nunez, Lazaro D, Mujica-Baella, Miguel, Murray, Alexander V, Oliver, Michael J, Oritz-Carrasquillo, Ramon, Palal, Betsy, Parke, Michael T, Philis-Tsimikas, Athena, Purighalla, Raman S, Rosenstock, Julio, Sathananthan, Airani, Shelton, Courtney, Sivalingam, Kanagaratnam, Sorial, Ehab, Soufer, Joseph, Stacey, Helen L, Stonesifer, Larry D, Stringam, Stanley, Van, Joanna T, Vazquez-Tanus, Jose B, Reyes, Ramon, Welch, Michelle, Karimjee, Najmuddin, Martin, Earl E, Arif, Ahmed, Jennings, Timothy W, Fraser, Neil J, Bhargava, Anuj, Wynne, Alan G, Davidson, Evelyne, Billings, Liana, Barranco-Santana, Elizabeth A, Dever, Michael E, Walsh, Patrick, Cho, Austina, Chu, James W, Shubrook, Jay, Knouse, Albert B, Nadar, Venkatesh, Lewy-Alterbaum, Lorena, Lillestol, Michael J, Humiston, Daniel J, White, Alexander J, Mayfield, Ronald K, Bitar, Fahed G, Cereto, Fernando, de la Cuesta, Carmen, De Teresa Parreno, Luis, Jodar Gimeno, Esteban, Mezquita-Raya, Pedro, Morales Portillo, Cristobal J, Quesada Charneco, Miguel, Tinahones Madueno, Francisco J, Tofe Povedano, Santiago, Vazquez, Luis, Fajardo Montañana, Carmen, Soto Gonzalez, Alfonso, Mistodie, Cristina, Szilagyi, Iosif, Filimon, Adriana, Mindrescu, Nicoleta M, Pop, Lavinia, Pascu, Marlena, Negrisanu, Gabriela D, Ciomos, Daniela, Neacsu, Valentina, Thury-Burileanu, Amalia, Liberty, Idit, Stern, Naftali, Sofer, Yael, Sack, Jessica, Shimon, Ilan, Tirosh, Amir, Ishay, Avraham, Mosenzon Ninio, Ofri, Shehadeh, Naim, Wainstein, Julio, Darawsha, Mahmud, Skripova, Dasa, Pavleova, Eva, Donicova, Viera, Kubincova, Ludmila, Sosovec, Dalibor, Merciakova, Martina, El Boreky, Fadia, St-Amour, Eric, Yared, Zeina, Blouin, Francois, Ajala, Buki, Aggarwal, Naresh K, Bajaj, Harpreet, Tailor, Chetna, Egan, Alan, O'Mahony, John, St.Onge, Natasha, Conway, James R, Akerman Augusto, Gustavo, Borges, Joao L C, Gomes Cerqueira, Maria José A, Franco, Denise R, Franco Hirakawa, Tatiana, Souza, Filipe D, Hissa, Miguel N, Pechmann, Luciana M, Calil Salim, Camila P, Russo, Luis Augusto T, Siqueira, Joselita, Sassone, Sonia A, Glenny, Jorge A, Koretzky, Martín, Aizenberg, Diego, Steinacher, Andrea, Solis, Silvana E, Nardone, Lucrecia, Perez Manghi, Federico C, Orio, Silvia I, Gelersztein, Elizabeth, Fretes, José O, Calella, Pedro R F, Zaidman, Cesar J, Chertkoff, Alejandro, Salzberg, Susana, Majul, Claudio R, Nevarez, Luis A, Violante Ortiz, Rafael M, Banda Elizondo, Ramiro G, Arjona Villicaña, Ruy D, Gonzalez Galvez, Guillermo, Calvo, Cesar G, Koscianski, Andrzej, Rudzki, Henryk, Stankiewicz, Andrzej W, Sowinski, Dariusz, Krzyzagorska, Ewa, Jozefowska, Malgorzata, Matyjaszek-Matuszek, Beata, Franek, Edward, Skokowska, Ewa, Modzelewska, Anna, Szyprowska, Ewa, Simpson, Richard W, Gilfillan, Christopher, Colquhoun, David M, Davis, Timothy M, Morbey, Claire, McCarthy, Shannon E, Kaur, Kamal, Kemp, Laurence, Shea, Antony J, Khalimov, Yuriy Sh, Miroshnichenko, Olga A, Dvoryashina, Irina V, Karpova, Irina A, Kunitsyna, Marina A, Vorokhobina, Natalia V, Galstyan, Gagik R, Bondar, Irina A., Filippov, Evgeniy V, Ershova, Olga B, Ou, Horng-Yih, Tseng, Shih-Ting, Chen, Jung-Fu, Tien, Kai-Jen, Huang, Chien-Ning, Chen, Ching-Chu, Hwu, Chii-Min, Hsia, Te-Lin, Doupis, John, Pagkalos, Emmanouil, Mouslech, Zadalla, Bargiota, Alexandra, Kotsa, Kalliopi, Del Prato, Stefano, Kahn, Steven E, Pavo, Imre, Weerakkody, Govinda J, Yang, Zhengyu, Riesmeyer, Jeffrey S, Heine, Robert J, and Wiese, Russell J

Published
2021
Full Text
View/download PDF

3. A double-blind, randomized, multicenter phase 2 study of prasugrel versus placebo in adult patients with sickle cell disease

Author

Wun, Ted, Soulieres, Denis, Frelinger, Andrew L, Krishnamurti, Lakshmanan, Novelli, Enrico M, Kutlar, Abdullah, Ataga, Kenneth I, Knupp, Charles L, McMahon, Lillian E, Strouse, John J, Zhou, Chunmei, Heath, Lori E, Nwachuku, Chuke E, Jakubowski, Joseph A, Riesmeyer, Jeffrey S, and Winters, Kenneth J

Abstract

Abstract Background Platelet activation has been implicated in the pathogenesis of sickle cell disease (SCD) suggesting antiplatelet agents may be therapeutic. To evaluate the safety of prasugrel, a thienopyridine antiplatelet agent, in adult patients with SCD, we conducted a double-blind, randomized, placebo-controlled study. Methods The primary endpoint, safety, was measured by hemorrhagic events requiring medical intervention. Patients were randomized to prasugrel 5 mg daily (n = 41) or placebo (n = 21) for 30 days. Platelet function by VerifyNow® P2Y12 and vasodilator-stimulated phosphoprotein assays at days 10 and 30 were significantly inhibited in prasugrel- compared with placebo-treated SCD patients. Results There were no hemorrhagic events requiring medical intervention in either study arm. Mean pain rate (percentage of days with pain) and intensity in the prasugrel arm were decreased compared with placebo. However, these decreases did not reach statistical significance. Platelet surface P-selectin and plasma soluble P-selectin, biomarkers of in vivo platelet activation, were significantly reduced in SCD patients receiving prasugrel compared with placebo. In sum, prasugrel was well tolerated and not associated with serious hemorrhagic events. Conclusions Despite the small size and short duration of this study, there was a decrease in platelet activation biomarkers and a trend toward decreased pain.

Published
2013

6. Impact of Regulatory Guidance on Evaluating Cardiovascular Risk of New Glucose-Lowering Therapies to Treat Type 2 Diabetes Mellitus: Lessons Learned and Future Directions

Author

Sharma, Abhinav, Pagidipati, Neha J., Califf, Robert M., McGuire, Darren K., Green, Jennifer B., Demets, Dave, George, Jyothis Thomas, Gerstein, Hertzel C., Hobbs, Todd, Holman, Rury R., Lawson, Francesca C., Leiter, Lawrence A., Pfeffer, Marc A., Reusch, Jane, Riesmeyer, Jeffrey S., Roe, Matthew T., Rosenberg, Yves, Temple, Robert, Wiviott, Stephen, McMurray, John, and Granger, Christopher

Published
2020
Full Text
View/download PDF

12. Efficacy and Safety of Tirzepatide versus Insulin Glargine in Patients with Type 2 Diabetes and Increased Cardiovascular Risk (SURPASS-4)

Author

Del Prato, Stefano, additional, Kahn, Steven E., additional, Pavo, Imre, additional, Weerakkody, Govinda J., additional, Yang, Zhengyu, additional, Doupis, John, additional, Aizenberg, Diego, additional, Wynne, Alan G., additional, Riesmeyer, Jeffrey S., additional, Heine, Robert J., additional, Wiese, Russell J., additional, and Seufert, Jochen, additional

Published
2022
Full Text
View/download PDF

13. Additional file 1 of Transitioning to active-controlled trials to evaluate cardiovascular safety and efficacy of medications for type 2 diabetes

Author

McGuire, Darren K., D’Alessio, David, Nicholls, Stephen J., Nissen, Steven E., Riesmeyer, Jeffrey S., Pavo, Imre, Sethuraman, Shanthi, Heilmann, Cory R., Kaiser, John J., and Weerakkody, Govinda J.

Abstract

Additional file 1. Bayesian hierarchical meta-analytic model. Posterior distribution of HR (tirzepatide versus dulaglutide) assuming SURPASS CVOT resulted in an observed HR (tirzepatide versus dulaglutide) of 0.95.

Published
2022
Full Text
View/download PDF

14. Tirzepatide versus insulin glargine in type 2 diabetes and increased cardiovascular risk (SURPASS-4): a randomised, open-label, parallel-group, multicentre, phase 3 trial

Author

Del Prato, Stefano, primary, Kahn, Steven E, additional, Pavo, Imre, additional, Weerakkody, Govinda J, additional, Yang, Zhengyu, additional, Doupis, John, additional, Aizenberg, Diego, additional, Wynne, Alan G, additional, Riesmeyer, Jeffrey S, additional, Heine, Robert J, additional, Wiese, Russell J, additional, Ahmann, Andrew J, additional, Arora, Samir, additional, Ball, Eric M, additional, Calderon, Rafael B, additional, Butuk, David J, additional, Chaychi, Leila, additional, Chen, Michael C, additional, Curtis, Brian M, additional, Chochinov, Ronald, additional, Chow, Christopher, additional, Cone, Clancy L, additional, Connery, Lisa, additional, Cortes-Maisonet, Gregorio A, additional, de Souza, Jose, additional, Dungan, Kathleen, additional, Bradley, David, additional, Frias, Juan P, additional, Gabra, Nashwa, additional, Gaudiani, Linda, additional, Herandez-Vazquez, Luis, additional, Hsia, Stanley H, additional, Jardula, Michael R, additional, Klein, Eric J, additional, Kutner, Mark E, additional, Loy, Juan, additional, Miranda, Francisco G, additional, Nunez, Lazaro D, additional, Mujica-Baella, Miguel, additional, Murray, Alexander V, additional, Oliver, Michael J, additional, Oritz-Carrasquillo, Ramon, additional, Palal, Betsy, additional, Parke, Michael T, additional, Philis-Tsimikas, Athena, additional, Purighalla, Raman S, additional, Rosenstock, Julio, additional, Sathananthan, Airani, additional, Shelton, Courtney, additional, Sivalingam, Kanagaratnam, additional, Sorial, Ehab, additional, Soufer, Joseph, additional, Stacey, Helen L, additional, Stonesifer, Larry D, additional, Stringam, Stanley, additional, Van, Joanna T, additional, Vazquez-Tanus, Jose B, additional, Reyes, Ramon, additional, Welch, Michelle, additional, Karimjee, Najmuddin, additional, Martin, Earl E, additional, Arif, Ahmed, additional, Jennings, Timothy W, additional, Fraser, Neil J, additional, Bhargava, Anuj, additional, Davidson, Evelyne, additional, Billings, Liana, additional, Barranco-Santana, Elizabeth A, additional, Dever, Michael E, additional, Walsh, Patrick, additional, Cho, Austina, additional, Chu, James W, additional, Shubrook, Jay, additional, Knouse, Albert B, additional, Nadar, Venkatesh, additional, Lewy-Alterbaum, Lorena, additional, Lillestol, Michael J, additional, Humiston, Daniel J, additional, White, Alexander J, additional, Mayfield, Ronald K, additional, Bitar, Fahed G, additional, Cereto, Fernando, additional, de la Cuesta, Carmen, additional, De Teresa Parreno, Luis, additional, Jodar Gimeno, Esteban, additional, Mezquita-Raya, Pedro, additional, Morales Portillo, Cristobal J, additional, Quesada Charneco, Miguel, additional, Tinahones Madueno, Francisco J, additional, Tofe Povedano, Santiago, additional, Vazquez, Luis, additional, Fajardo Montañana, Carmen, additional, Soto Gonzalez, Alfonso, additional, Mistodie, Cristina, additional, Szilagyi, Iosif, additional, Filimon, Adriana, additional, Mindrescu, Nicoleta M, additional, Pop, Lavinia, additional, Pascu, Marlena, additional, Negrisanu, Gabriela D, additional, Ciomos, Daniela, additional, Neacsu, Valentina, additional, Thury-Burileanu, Amalia, additional, Liberty, Idit, additional, Stern, Naftali, additional, Sofer, Yael, additional, Sack, Jessica, additional, Shimon, Ilan, additional, Tirosh, Amir, additional, Ishay, Avraham, additional, Mosenzon Ninio, Ofri, additional, Shehadeh, Naim, additional, Wainstein, Julio, additional, Darawsha, Mahmud, additional, Skripova, Dasa, additional, Pavleova, Eva, additional, Donicova, Viera, additional, Kubincova, Ludmila, additional, Sosovec, Dalibor, additional, Merciakova, Martina, additional, El Boreky, Fadia, additional, St-Amour, Eric, additional, Yared, Zeina, additional, Blouin, Francois, additional, Ajala, Buki, additional, Aggarwal, Naresh K, additional, Bajaj, Harpreet, additional, Tailor, Chetna, additional, Egan, Alan, additional, O'Mahony, John, additional, St.Onge, Natasha, additional, Conway, James R, additional, Akerman Augusto, Gustavo, additional, Borges, Joao L C, additional, Gomes Cerqueira, Maria José A, additional, Franco, Denise R, additional, Franco Hirakawa, Tatiana, additional, Souza, Filipe D, additional, Hissa, Miguel N, additional, Pechmann, Luciana M, additional, Calil Salim, Camila P, additional, Russo, Luis Augusto T, additional, Siqueira, Joselita, additional, Sassone, Sonia A, additional, Glenny, Jorge A, additional, Koretzky, Martín, additional, Steinacher, Andrea, additional, Solis, Silvana E, additional, Nardone, Lucrecia, additional, Perez Manghi, Federico C, additional, Orio, Silvia I, additional, Gelersztein, Elizabeth, additional, Fretes, José O, additional, Calella, Pedro R F, additional, Zaidman, Cesar J, additional, Chertkoff, Alejandro, additional, Salzberg, Susana, additional, Majul, Claudio R, additional, Nevarez, Luis A, additional, Violante Ortiz, Rafael M, additional, Banda Elizondo, Ramiro G, additional, Arjona Villicaña, Ruy D, additional, Gonzalez Galvez, Guillermo, additional, Calvo, Cesar G, additional, Koscianski, Andrzej, additional, Rudzki, Henryk, additional, Stankiewicz, Andrzej W, additional, Sowinski, Dariusz, additional, Krzyzagorska, Ewa, additional, Jozefowska, Malgorzata, additional, Matyjaszek-Matuszek, Beata, additional, Franek, Edward, additional, Skokowska, Ewa, additional, Modzelewska, Anna, additional, Szyprowska, Ewa, additional, Simpson, Richard W, additional, Gilfillan, Christopher, additional, Colquhoun, David M, additional, Davis, Timothy M, additional, Morbey, Claire, additional, McCarthy, Shannon E, additional, Kaur, Kamal, additional, Kemp, Laurence, additional, Shea, Antony J, additional, Khalimov, Yuriy Sh, additional, Miroshnichenko, Olga A, additional, Dvoryashina, Irina V, additional, Karpova, Irina A, additional, Kunitsyna, Marina A, additional, Vorokhobina, Natalia V, additional, Galstyan, Gagik R, additional, Bondar, Irina A., additional, Filippov, Evgeniy V, additional, Ershova, Olga B, additional, Ou, Horng-Yih, additional, Tseng, Shih-Ting, additional, Chen, Jung-Fu, additional, Tien, Kai-Jen, additional, Huang, Chien-Ning, additional, Chen, Ching-Chu, additional, Hwu, Chii-Min, additional, Hsia, Te-Lin, additional, Pagkalos, Emmanouil, additional, Mouslech, Zadalla, additional, Bargiota, Alexandra, additional, and Kotsa, Kalliopi, additional

Published
2021
Full Text
View/download PDF

15. Evacetrapib and Cardiovascular Outcomes in High-Risk Vascular Disease

Author

Lincoff, A. Michael, Nicholls, Stephen J., Riesmeyer, Jeffrey S., Barter, Philip J., Brewer, H. Bryan, Fox, Keith A. A., Gibson, C. Michael, Granger, Christopher, Menon, Venu, Montalescot, Gilles, Rader, Daniel, Tall, Alan R., McErlean, Ellen, Wolski, Kathy, Ruotolo, Giacomo, Vangerow, Burkhard, Weerakkody, Govinda, Goodman, Shaun G., Conde, Diego, McGuire, Darren K., Nicolau, Jose C., Leiva-Pons, Jose L., Pesant, Yves, Li, Weimin, Kandath, David, Kouz, Simon, Tahirkheli, Naeem, Mason, Denise, Nissen, Steven E. Del Valle M, Finnell JB, Standley J, Poi K, Croaning J, Tong YC, Guerra JL, Guasparini G, Hubert C, Ardissino D, Betteridge J, Borghi C, Bruckert E, Chiang CE, Cinteza M, Dalby AJ, Erlinge D, Fernandez-Ortiz A, Ge J, Gottlieb S, Goudev A, Gratsiansky N, Huber K, Ilavská A, Jeong MH, Jukema JW, Katus H, Keltai M, Krum H, Nielsen H, Ogawa H, Ongen Z, Parkhomenko A, Raugaliene R, Renkin J, Rynkiewicz A, Steinhubl S, White H, Widimsky P, Zhu J, Armstrong P, Ridker P, Mahaffey K, Steg G, Wittes J, Bhargava A, Chenier M, Coleman C, Cremer P, Jellis C, Lahoud R, Lappe J, Min D, Monteleone P, Newton D, Stegman B, Senn T, Katzan I, Sharma J, Uchino K, Vora N, Brown K, Fabec D, Piper P, Preston S, Colombo T, Pagel-Langenickel I, Penev P, Maixing A, Crowley K, Sarkar S, Torosyan N, Castano L, Tran D, Dena V, Blain L, Keenan G, Slade K, Quinlan E, Edwards R, Ren H, Glenny J, Maffei L, Albisu Di Gennaro J, Caccavo A, Prado A, Colombo H, Luquez H, Lobo Marquez L, Hammett C, Blombery P, Colquhoun D, Amerena J, Howes L, Cooke D, Simpson R, Horowitz J, Sullivan D, Proietto J, Yeo W, Hirschl M, Hanusch U, Drexel H, Brodmann M, Wollaert B, De Wolf L, Delforge M, Vanwelden J, Peeters A, Siqueira Bodart J, Montenegro R, Franken M, Eliaschewitz F, Parvanova Z, Raev D, Mincheva V, Kichukov K, Stoyanov M, Apostolova E, Tzekova M, Dimov B, Lazov P, Devedzhiev T, Dion D, Poirier P, Lavoie JP, Lonn E, Shukla D, Chehayeb R, Nault P, Gaudet D, Tardif JC, Beaudry Y, Bakbak A, Wong B, St-Maurice F, Labonte R, Polasek P, Sweet M, Bhargava R, Nawaz S, Pandey S, Tishler S, Peterson S, O’Keefe D, Genest J, Syan R, Leiter L, Li H, Ma W, Ma C, Xu D, Li X, Hala T, Machova V, Smejkalova O, Vodnansky P, Reichert P, Velimsky T, Matuska J, Machkova M, Jerabek O, Kuchar J, Rasmussen T, Lindgren L, Alexandersen P, Bang L, Brønnum-Schou J, Valter I, Soots M, Lanno R, Rosenthal S, Cottin Y, Elbaz M, Lafitte S, Silvain J, Coste P, Rangé G, Gosse P, Morel O, Berrouschot J, Bourhaial H, Toursarkissian N, Appel KF, Rieker W, Stellbrink C, Münzel T, Geisler T, Kadel C, Giannitsis E, Trenk D, vom Dahl J, Dorsel T, Singer O, Schäufele T, Natour M, Ozaki R, Lau E, Chan K, Yeung V, Yu C, Lakatos F, Zólyomi S, Vangel S, Merkely B, Szakal I, Sipos A, Laszloczky A, Kis E, Szocs A, Szántai G, Faludi P, Kancz S, Oroszlan T, Hamoud S, Francis A, Chorin E, Leibowitz D, Kracoff O, Weisz G, Schiff E, Bitzur R, Hussein O, Di Lorenzo L, Visona A, Mos L, De Luca G, Salvioni A, Rubba P, Imberti D, Bucci M, Saku K, Sueyoshi A, Ohshima K, Kazatani Y, Shimizu M, Fujii K, Higa N, Kawamitsu K, Shimomura H, Hoshizaki H, Tashiro H, Baden M, Ueda O, Tanabe J, Momiyama Y, Hosokawa S, Takahashi N, Kimura K, Fujinaga H, Masutani M, Kuramochi T, Higashikata T, Ichikawa S, Yamagishi M, Sakota S, Sakuragi S, Suzuki M, Taguchi S, Nakamura T, Ozaki Y, Tsujita K, Yasuda S, Ando K, Fujimoto K, Tanabe K, Fukunaga M, Kavaliauskiene R, Motiejuniene L, Slapikas R, Jarasuniene D, De los Rios Ibarra M, Alcocer Gamba M, Nevarez Ruiz L, Fajardo-Campos P, Llamas Esperon G, Violante Ortiz R, Stobschinski de Alba C, Guizar Sanchez C, Guerra Lopez A, Montano E, Miracle S, Fanghanel G, Lenderink T, Troquay R, Van Leendert R, van Eck J, Hamer B, Ronner E, Karalis I, Lok D, Magro M, Westendorp I, Stroes E, De Melker E, Verhave G, Plomp J, Bronzwaer P, Wiersma J, Kooy A, Herrman JP, Imholz B, de Groot M, Devlin G, Elliott J, Benatar J, Harding S, Hart H, Young C, Mirek-Bryniarska E, Gniot J, Broncel M, Kozina M, Kus W, Sciborski R, Lesnik J, Kawka-Urbanek T, Krzyzanowski M, Okopien B, Wierzbicka K, Dyczek A, Ochean V, Copaci I, Matei C, Pruna C, Constantinescu M, Minescu B, Stamate C, Boldueva S, Markov V, Alexeeva N, Chizhov P, Supryadkina T, Petrochenkova N, Zrazhevsky K, Barbarash O, Gurevich V, Hranai M, Gergel V, Dzupina A, Uhliar R, Vinanska D, Fazekas F, Bugan W, Saaiman J, Nortje H, Theron H, Bernhardi D, Ramlachan P, Van-Zyl L, Basson M, Venter T, Kim D, Han S, Park G, Hwang K, Rhee M, Cho B, Jeong J, Hong B, Chang K, Garcia Puig J, Fuentes Jiménez F, Nieto Iglesias LJ, Pintó Sala X, Gamez JM, Sánchez Álvarez J, Hernandez García JM, Olsson A, Mooe T, Tengmark BO, Lindholm CJ, Hansen O, Tyden P, Moccetti T, Binder R, Ueng K, Lai W, Shyu K, Hsieh I, Sheu W, Chen J, Altunkeser B, Erkan A, Karpenko O, Kaydashev I, Yagensky A, Kovalenko V, Brunskill J, Barr C, Cecil J, Cahill T, A Gorog D, Bakhai A, Coulson W, Gorog D, Loftus I, Haddad T, Hotchkiss D, Isserman S, Janik M, Weinstein D, Wilson S, Butman S, Hearne S, Khan F, Nadar V, Zelman R, Benton R, Flores E, Kahn B, Soni A, Asbill B, Singal D, Dy J, Foucauld J, Crenshaw B, Rogers W, Aslam A, Lieber I, Shah P, Durr S, Spencer R, Mahal S, Cheng S, Abadier R, Gilmore R, Staniloae C, Miller G, Seals A, Jetty P, Mathis C, Henry S, Murray A, Felten W, Navas J, Gudipati R, Singh N, West S, Sabatino K, Crater T, Amin J, Dosh K, Earl J, Z Jafar M, Gelernt M, Kutner M, Salazar J, Krantzler J, El-Ahdab F, Lader E, Zakhary B, Miller S, Madder R, Khan T, Khan M, Collis W, Evans J, Prodafikas J, Panchal V, Cohen K, Weiss R, Dietrich D, Vogel C, Mascarenhas V, Seaworth J, Teklinski A, Davalos J, Dehning M, Herzog W, Snyder H, Talano J, Donahoe S, Hunter J, Sandoval J, Batchelor W, Brautigam D, Moriarty K, Siachos A, Kereiakes D, Traboulssi M, Arif I, Kosinski E, Quadrel M, DeHart D, Miller M, Poock J, Loh I, van Cleeff M, Georgeson S, Suryanarayana P, Cohn J, Schmedtje J, Lamas G, DeSantis J, Stahl L, Prashad R, Schuchard T, Schramm E, Rao V, Deen C, Soufer J, Gurbel P, Vazquez-Tanus J, Srivastava S, Ballantyne C, Lotun K, Younis L, Gupta D, Yeoman G, Zebrack J, Knutson T, Whitaker J, Appel M, Koren M, Muneer B, Fairlamb J, Aviles R, Kozlowski L, Rees A, Stephens M, Mays M, Downey H, Almassi H, Peichert D, Rocco M, French W, Bhatia P, Hoch J, Peart B, Carmichael P, Acheatel R, Vo A, Kirtane A, Bhagwat R, Gilchrist I, Labroo A, Pollock S, Bacon J, Karunaratne H, Moursi M, Doshi A, Sethi P, Treasure C, Marple R, Goodwin T, Zayas-Torres C, Loussararian A, Korn D, Paster R, Albirini A, Moretto T, Guarnieri T, White L, Kramer J, Shortal B, Maynard K, Raikhel M, Rohatgi A, Melucci M, Masri B, Krichmar P, Morris F, Canto J, Wali A, Comerota A, Ellison W, Degregorio M, Chandrika Parameswaran A, Goldscher D, George W, Mulkay A, Maynard R, Ziada K, Strain J, Hermiller J, Ennis B, Desai V, Al-Joundi B, Azocar J, Claudio J, Perez Vargas E, Loy J, Albert M, Chandler G, Maislos F, Graf R, Rama P, Studeny M, Gimple L, Pytlewski G, Simon H, Islam A, Dillon W, Shah S, Geohas C., Lincoff, Am, Nicholls, Sj, Riesmeyer, J, Barter, Pj, Brewer, Hb, Fox, Kaa, Gibson, Cm, Granger, C, Menon, V, Montalescot, G, Rader, D, Tall, Ar, Mcerlean, E, Wolski, K, Ruotolo, G, Vangerow, B, Weerakkody, G, Goodman, Sg, Conde, D, Mcguire, Dk, Nicolau, Jc, Leiva-Pons, Jl, Pesant, Y, Li, W, Kandath, D, Kouz, S, Tahirkheli, N, Mason, D, Nissen, Se, Del Valle, M, Finnell, Jb, Standley, J, Poi, K, Croaning, J, Tong, Yc, Guerra, Jl, Guasparini, G, Hubert, C, Ardissino, D, Betteridge, J, Borghi, C, Bruckert, E, Chiang, Ce, Cinteza, M, Dalby, Aj, Erlinge, D, Fernandez-Ortiz, A, Ge, J, Gottlieb, S, Goudev, A, Gratsiansky, N, Huber, K, Ilavská, A, Jeong, Mh, Jukema, Jw, Katus, H, Keltai, M, Krum, H, Nielsen, H, Ogawa, H, Ongen, Z, Parkhomenko, A, Raugaliene, R, Renkin, J, Rynkiewicz, A, Steinhubl, S, White, H, Widimsky, P, Zhu, J, Armstrong, P, Ridker, P, Mahaffey, K, Steg, G, Wittes, J, Bhargava, A, Chenier, M, Coleman, C, Cremer, P, Jellis, C, Lahoud, R, Lappe, J, Min, D, Monteleone, P, Newton, D, Stegman, B, Senn, T, Katzan, I, Sharma, J, Uchino, K, Vora, N, Brown, K, Fabec, D, Piper, P, Preston, S, Colombo, T, Pagel-Langenickel, I, Penev, P, Maixing, A, Crowley, K, Sarkar, S, Torosyan, N, Castano, L, Tran, D, Dena, V, Blain, L, Keenan, G, Slade, K, Quinlan, E, Edwards, R, Ren, H, Glenny, J, Maffei, L, Albisu Di Gennaro, J, Caccavo, A, Prado, A, Colombo, H, Luquez, H, Lobo Marquez, L, Hammett, C, Blombery, P, Colquhoun, D, Amerena, J, Howes, L, Cooke, D, Simpson, R, Horowitz, J, Sullivan, D, Proietto, J, Yeo, W, Hirschl, M, Hanusch, U, Drexel, H, Brodmann, M, Wollaert, B, De Wolf, L, Delforge, M, Vanwelden, J, Peeters, A, Siqueira Bodart, J, Montenegro, R, Franken, M, Eliaschewitz, F, Parvanova, Z, Raev, D, Mincheva, V, Kichukov, K, Stoyanov, M, Apostolova, E, Tzekova, M, Dimov, B, Lazov, P, Devedzhiev, T, Dion, D, Poirier, P, Lavoie, Jp, Lonn, E, Shukla, D, Chehayeb, R, Nault, P, Gaudet, D, Tardif, Jc, Beaudry, Y, Bakbak, A, Wong, B, St-Maurice, F, Labonte, R, Polasek, P, Sweet, M, Bhargava, R, Nawaz, S, Pandey, S, Tishler, S, Peterson, S, O’Keefe, D, Genest, J, Syan, R, Leiter, L, Li, H, Ma, W, Ma, C, Xu, D, Li, X, Hala, T, Machova, V, Smejkalova, O, Vodnansky, P, Reichert, P, Velimsky, T, Matuska, J, Machkova, M, Jerabek, O, Kuchar, J, Rasmussen, T, Lindgren, L, Alexandersen, P, Bang, L, Brønnum-Schou, J, Valter, I, Soots, M, Lanno, R, Rosenthal, S, Cottin, Y, Elbaz, M, Lafitte, S, Silvain, J, Coste, P, Rangé, G, Gosse, P, Morel, O, Berrouschot, J, Bourhaial, H, Toursarkissian, N, Appel, Kf, Rieker, W, Stellbrink, C, Münzel, T, Geisler, T, Kadel, C, Giannitsis, E, Trenk, D, vom Dahl, J, Dorsel, T, Singer, O, Schäufele, T, Natour, M, Ozaki, R, Lau, E, Chan, K, Yeung, V, Yu, C, Lakatos, F, Zólyomi, S, Vangel, S, Merkely, B, Szakal, I, Sipos, A, Laszloczky, A, Kis, E, Szocs, A, Szántai, G, Faludi, P, Kancz, S, Oroszlan, T, Hamoud, S, Francis, A, Chorin, E, Leibowitz, D, Kracoff, O, Weisz, G, Schiff, E, Bitzur, R, Hussein, O, Di Lorenzo, L, Visona, A, Mos, L, De Luca, G, Salvioni, A, Rubba, P, Imberti, D, Bucci, M, Saku, K, Sueyoshi, A, Ohshima, K, Kazatani, Y, Shimizu, M, Fujii, K, Higa, N, Kawamitsu, K, Shimomura, H, Hoshizaki, H, Tashiro, H, Baden, M, Ueda, O, Tanabe, J, Momiyama, Y, Hosokawa, S, Takahashi, N, Kimura, K, Fujinaga, H, Masutani, M, Kuramochi, T, Higashikata, T, Ichikawa, S, Yamagishi, M, Sakota, S, Sakuragi, S, Suzuki, M, Taguchi, S, Nakamura, T, Ozaki, Y, Tsujita, K, Yasuda, S, Ando, K, Fujimoto, K, Tanabe, K, Fukunaga, M, Kavaliauskiene, R, Motiejuniene, L, Slapikas, R, Jarasuniene, D, De los Rios Ibarra, M, Alcocer Gamba, M, Nevarez Ruiz, L, Fajardo-Campos, P, Llamas Esperon, G, Violante Ortiz, R, Stobschinski de Alba, C, Guizar Sanchez, C, Guerra Lopez, A, Montano, E, Miracle, S, Fanghanel, G, Lenderink, T, Troquay, R, Van Leendert, R, van Eck, J, Hamer, B, Ronner, E, Karalis, I, Lok, D, Magro, M, Westendorp, I, Stroes, E, De Melker, E, Verhave, G, Plomp, J, Bronzwaer, P, Wiersma, J, Kooy, A, Herrman, Jp, Imholz, B, de Groot, M, Devlin, G, Elliott, J, Benatar, J, Harding, S, Hart, H, C, Young, Mirek-Bryniarska, E, Gniot, J, Broncel, M, Kozina, M, Kus, W, Sciborski, R, Lesnik, J, Kawka-Urbanek, T, Krzyzanowski, M, Okopien, B, Wierzbicka, K, Dyczek, A, Ochean, V, Copaci, I, Matei, C, Pruna, C, Constantinescu, M, Minescu, B, Stamate, C, Boldueva, S, Markov, V, Alexeeva, N, Chizhov, P, Supryadkina, T, Petrochenkova, N, Zrazhevsky, K, Barbarash, O, Gurevich, V, Hranai, M, Gergel, V, Dzupina, A, Uhliar, R, Vinanska, D, Fazekas, F, Bugan, W, Saaiman, J, Nortje, H, Theron, H, Bernhardi, D, Ramlachan, P, Van-Zyl, L, Basson, M, Venter, T, Kim, D, Han, S, Park, G, Hwang, K, Rhee, M, Cho, B, Jeong, J, Hong, B, Chang, K, Garcia Puig, J, Fuentes Jiménez, F, Nieto Iglesias LJ, Pintó Sala, X, Gamez, Jm, Sánchez Álvarez, J, Hernandez García JM, Olsson, A, Mooe, T, Tengmark, Bo, Lindholm, Cj, Hansen, O, Tyden, P, Moccetti, T, Binder, R, Ueng, K, Lai, W, Shyu, K, Hsieh, I, Sheu, W, Chen, J, Altunkeser, B, Erkan, A, Karpenko, O, Kaydashev, I, Yagensky, A, Kovalenko, V, Brunskill, J, Barr, C, Cecil, J, Cahill, T, A Gorog D, Bakhai, A, Coulson, W, Gorog, D, Loftus, I, Haddad, T, Hotchkiss, D, Isserman, S, Janik, M, Weinstein, D, Wilson, S, Butman, S, Hearne, S, Khan, F, Nadar, V, Zelman, R, R, Benton, E, Flore, Kahn, B, Soni, A, Asbill, B, Singal, D, Dy, J, Foucauld, J, Crenshaw, B, Rogers, W, Aslam, A, Lieber, I, Shah, P, Durr, S, Spencer, R, Mahal, S, Cheng, S, Abadier, R, Gilmore, R, Staniloae, C, Miller, G, Seals, A, Jetty, P, Mathis, C, Henry, S, Murray, A, Felten, W, Navas, J, Gudipati, R, Singh, N, West, S, Sabatino, K, Crater, T, Amin, J, Dosh, K, Earl, J, Z Jafar M, Gelernt, M, Kutner, M, J, Salazar, Krantzler, J, El-Ahdab, F, Lader, E, Zakhary, B, Miller, S, Madder, R, Khan, T, Khan, M, Collis, W, Evans, J, Prodafikas, J, Panchal, V, Cohen, K, Weiss, R, Dietrich, D, Vogel, C, Mascarenhas, V, Seaworth, J, Teklinski, A, Davalos, J, Dehning, M, Herzog, W, Snyder, H, Talano, J, Donahoe, S, Hunter, J, Sandoval, J, Batchelor, W, Brautigam, D, Moriarty, K, Siachos, A, Kereiakes, D, Traboulssi, M, Arif, I, Kosinski, E, Quadrel, M, Dehart, D, Miller, M, Poock, J, Loh, I, van Cleeff, M, Georgeson, S, Suryanarayana, P, Cohn, J, Schmedtje, J, Lamas, G, Desantis, J, Stahl, L, Prashad, R, Schuchard, T, Schramm, E, Rao, V, Deen, C, Soufer, J, Gurbel, P, Vazquez-Tanus, J, Srivastava, S, Ballantyne, C, Lotun, K, Younis, L, Gupta, D, Yeoman, G, Zebrack, J, Knutson, T, Whitaker, J, Appel, M, Koren, M, Muneer, B, Fairlamb, J, Aviles, R, Kozlowski, L, Rees, A, Stephens, M, Mays, M, Downey, H, Almassi, H, Peichert, D, Rocco, M, French, W, Bhatia, P, Hoch, J, Peart, B, Carmichael, P, Acheatel, R, Vo, A, Kirtane, A, Bhagwat, R, Gilchrist, I, Labroo, A, Pollock, S, Bacon, J, Karunaratne, H, Moursi, M, Doshi, A, Sethi, P, Treasure, C, Marple, R, Goodwin, T, Zayas-Torres, C, Loussararian, A, Korn, D, Paster, R, Albirini, A, Moretto, T, Guarnieri, T, White, L, Kramer, J, Shortal, B, Maynard, K, Raikhel, M, Rohatgi, A, Melucci, M, Masri, B, Krichmar, P, Morris, F, Canto, J, Wali, A, Comerota, A, Ellison, W, Degregorio, M, Chandrika Parameswaran, A, Goldscher, D, George, W, Mulkay, A, Maynard, R, Ziada, K, Strain, J, Hermiller, J, Ennis, B, Desai, V, Al-Joundi, B, Azocar, J, Claudio, J, Perez Vargas, E, Loy, J, Albert, M, Chandler, G, Maislos, F, Graf, R, Rama, P, Studeny, M, Gimple, L, Pytlewski, G, Simon, H, Islam, A, Dillon, W, Shah, S, Geohas, C., Lincoff, A. Michael, Nicholls, Stephen J., Riesmeyer, Jeffrey S., Barter, Philip J., Brewer, H. Bryan, Fox, Keith A. A., Gibson, C. Michael, Granger, Christopher, Menon, Venu, Montalescot, Gille, Rader, Daniel, Tall, Alan R., Mcerlean, Ellen, Wolski, Kathy, Ruotolo, Giacomo, Vangerow, Burkhard, Weerakkody, Govinda, Goodman, Shaun G., Conde, Diego, Mcguire, Darren K., Nicolau, Jose C., Leiva-Pons, Jose L., Pesant, Yve, Li, Weimin, Kandath, David, Kouz, Simon, Tahirkheli, Naeem, Mason, Denise, Nissen, Steven E., Del Valle M, Young, C, Nieto Iglesias, Lj, Hernandez García, Jm, A Gorog, D, Benton, R, Flores, E, Z Jafar, M, and Salazar, J

Subjects
Male, 0301 basic medicine, Cardiovascular Outcome, Cholesterol Ester Transfer Protein, Myocardial Ischemia, 030204 cardiovascular system & hematology, Coronary artery disease, cholesteryl ester transfer protein inhibitor, Benzodiazepines, chemistry.chemical_compound, 0302 clinical medicine, Cardiovascular Disease, Anticholesteremic Agent, Intracranial Arteriosclerosi, Treatment Failure, Evacetrapib, Peripheral Vascular Diseases, Benzodiazepine, biology, Medicine (all), Anticholesteremic Agents, Diabetes Mellitu, General Medicine, Middle Aged, Intracranial Arteriosclerosis, High-Risk Vascular Disease, Editorial, Cardiovascular Diseases, Cardiology, Female, lipids (amino acids, peptides, and proteins), Human, Risk, medicine.medical_specialty, Acute coronary syndrome, 03 medical and health sciences, Double-Blind Method, Internal medicine, Diabetes mellitus, Cholesterylester transfer protein, Diabetes Mellitus, Journal Article, medicine, Humans, Aged, Cholesterol, Vascular disease, business.industry, Cholesterol, HDL, Biomarker, Cholesterol, LDL, medicine.disease, Cholesterol Ester Transfer Proteins, Surgery, 030104 developmental biology, Peripheral Vascular Disease, chemistry, biology.protein, business, Biomarkers, Lipoprotein
Abstract

BACKGROUND: The cholesteryl ester transfer protein inhibitor evacetrapib substantially raises the high-density lipoprotein (HDL) cholesterol level, reduces the low-density lipoprotein (LDL) cholesterol level, and enhances cellular cholesterol efflux capacity. We sought to determine the effect of evacetrapib on major adverse cardiovascular outcomes in patients with high-risk vascular disease. METHODS: In a multicenter, randomized, double-blind, placebo-controlled phase 3 trial, we enrolled 12,092 patients who had at least one of the following conditions: an acute coronary syndrome within the previous 30 to 365 days, cerebrovascular atherosclerotic disease, peripheral vascular arterial disease, or diabetes mellitus with coronary artery disease. Patients were randomly assigned to receive either evacetrapib at a dose of 130 mg or matching placebo, administered daily, in addition to standard medical therapy. The primary efficacy end point was the first occurrence of any component of the composite of death from cardiovascular causes, myocardial infarction, stroke, coronary revascularization, or hospitalization for unstable angina. RESULTS: At 3 months, a 31.1% decrease in the mean LDL cholesterol level was observed with evacetrapib versus a 6.0% increase with placebo, and a 133.2% increase in the mean HDL cholesterol level was seen with evacetrapib versus a 1.6% increase with placebo. After 1363 of the planned 1670 primary end-point events had occurred, the data and safety monitoring board recommended that the trial be terminated early because of a lack of efficacy. After a median of 26 months of evacetrapib or placebo, a primary end-point event occurred in 12.9% of the patients in the evacetrapib group and in 12.8% of those in the placebo group (hazard ratio, 1.01; 95% confidence interval, 0.91 to 1.11; P=0.91). CONCLUSIONS: Although the cholesteryl ester transfer protein inhibitor evacetrapib had favorable effects on established lipid biomarkers, treatment with evacetrapib did not result in a lower rate of cardiovascular events than placebo among patients with high-risk vascular disease. (Funded by Eli Lilly; ACCELERATE ClinicalTrials.gov number, NCT01687998 .).

Published
2017

19. Effect of C-Reactive Protein on Lipoprotein(a)-Associated Cardiovascular Risk in Optimally Treated Patients With High-Risk Vascular Disease

Author

Puri, Rishi, primary, Nissen, Steven E., additional, Arsenault, Benoit J., additional, St John, Julie, additional, Riesmeyer, Jeffrey S., additional, Ruotolo, Giacomo, additional, McErlean, Ellen, additional, Menon, Venu, additional, Cho, Leslie, additional, Wolski, Kathy, additional, Lincoff, A. Michael, additional, and Nicholls, Stephen J., additional

Published
2020
Full Text
View/download PDF

20. The dual glucose‐dependent insulinotropic peptide and glucagon‐like peptide‐1 receptor agonist, tirzepatide, improves lipoprotein biomarkers associated with insulin resistance and cardiovascular risk in patients with type 2 diabetes

Author

Wilson, Jonathan M., primary, Nikooienejad, Amir, additional, Robins, Deborah A., additional, Roell, William C., additional, Riesmeyer, Jeffrey S., additional, Haupt, Axel, additional, Duffin, Kevin L., additional, Taskinen, Marja‐Riitta, additional, and Ruotolo, Giacomo, additional

Published
2020
Full Text
View/download PDF

21. Genome-Wide Polygenic Score and Cardiovascular Outcomes With Evacetrapib in Patients With High-Risk Vascular Disease

Author

Emdin, Connor A., primary, Bhatnagar, Pallav, additional, Wang, Minxian, additional, Pillai, Sreekumar G., additional, Li, Lin, additional, Qian, Hui-Rong, additional, Riesmeyer, Jeffrey S., additional, Lincoff, A. Michael, additional, Nicholls, Stephen J., additional, Nissen, Steven E., additional, Ruotolo, Giacomo, additional, Kathiresan, Sekar, additional, and Khera, Amit V., additional

Published
2020
Full Text
View/download PDF

22. Impact of Baseline Glycemic Control on Residual Cardiovascular Risk in Patients With Diabetes Mellitus and High‐Risk Vascular Disease Treated With Statin Therapy

Author

Menon, Venu, primary, Kumar, Anirudh, additional, Patel, Divyang R., additional, St. John, Julie, additional, Wolski, Kathy E., additional, McErlean, Ellen, additional, Riesmeyer, Jeffrey S., additional, Weerakkody, Govinda, additional, Ruotolo, Giacomo, additional, Cremer, Paul C., additional, Nicholls, Stephen J., additional, Lincoff, A. Michael, additional, and Nissen, Steven E., additional

Published
2020
Full Text
View/download PDF

23. The Role of Lipoprotein (a) as a Marker of Residual Risk in Patients With Diabetes and Established Cardiovascular Disease on Optimal Medical Therapy: Post Hoc Analysis of ACCELERATE

Author

Shah, Nishant P., primary, Wang, Qiuqing, additional, Wolski, Katherine E., additional, Cho, Leslie, additional, McErlean, Ellen, additional, Ruotolo, Giacomo, additional, Weerakkody, Govinda, additional, Riesmeyer, Jeffrey S., additional, Nicholls, Stephen J., additional, Lincoff, A. Michael, additional, Nissen, Steven E., additional, and Menon, Venu, additional

Published
2019
Full Text
View/download PDF

24. Plasma Aldosterone Levels Are Not Associated With Cardiovascular Events Among Patients With High‐Risk Vascular Disease: Insights From the ACCELERATE Trial

Author

Kumar, Anirudh, primary, Patel, Divyang R., additional, Brennan, Danielle M., additional, Wolski, Kathy E., additional, Lincoff, A. Michael, additional, Ruotolo, Giacomo, additional, McErlean, Ellen, additional, Weerakkody, Govinda, additional, Riesmeyer, Jeffrey S., additional, Nicholls, Stephen J., additional, Nissen, Steven E., additional, and Menon, Venu, additional

Published
2019
Full Text
View/download PDF

26. Dulaglutide and cardiovascular outcomes in type 2 diabetes (REWIND): a double-blind, randomised placebo-controlled trial

Author

Gerstein, Hertzel C, primary, Colhoun, Helen M, additional, Dagenais, Gilles R, additional, Diaz, Rafael, additional, Lakshmanan, Mark, additional, Pais, Prem, additional, Probstfield, Jeffrey, additional, Riesmeyer, Jeffrey S, additional, Riddle, Matthew C, additional, Rydén, Lars, additional, Xavier, Denis, additional, Atisso, Charles Messan, additional, Dyal, Leanne, additional, Hall, Stephanie, additional, Rao-Melacini, Purnima, additional, Wong, Gloria, additional, Avezum, Alvaro, additional, Basile, Jan, additional, Chung, Namsik, additional, Conget, Ignacio, additional, Cushman, William C, additional, Franek, Edward, additional, Hancu, Nicolae, additional, Hanefeld, Markolf, additional, Holt, Shaun, additional, Jansky, Petr, additional, Keltai, Matyas, additional, Lanas, Fernando, additional, Leiter, Lawrence A, additional, Lopez-Jaramillo, Patricio, additional, Cardona Munoz, Ernesto German, additional, Pirags, Valdis, additional, Pogosova, Nana, additional, Raubenheimer, Peter J, additional, Shaw, Jonathan E, additional, Sheu, Wayne H-H, additional, Temelkova-Kurktschiev, Theodora, additional, Abella, Mercedes, additional, Alebuena, Andrea, additional, Almagro, Sandra, additional, Amoroso, Eduardo, additional, Anadon, Paula, additional, Andreu, Elizabeth, additional, Aristimuño, Guillermo, additional, Arzadun, Maria, additional, Barbieri, Maria, additional, Barcudi, Raul, additional, Bartolacci, Ines, additional, Bolobanich, Gabriel, additional, Bordonava, Anselmo, additional, Bustamante Labarta, Miguel, additional, Bustos, Betina, additional, Caccavo, Alberto, additional, Camino, Alejandra, additional, Cantero, Maria, additional, Carignano, Maria, additional, Cartasegna, Luis, additional, Cipullo, Marcela, additional, Commendatore, Víctor, additional, Conosciuto, Victoria, additional, Costamagna, Osvaldo, additional, Crespo, Claudia, additional, Cuello, Jose, additional, Cuneo, Carlos, additional, Cusimano, Sandra, additional, Dean, Sofia, additional, Dituro, Claudio, additional, Dominguez, Andrea, additional, Farah, Miguel, additional, Fernandez, Alberto, additional, Fernandez, Florencia, additional, Ferrari, Adriana, additional, Flammia, Patricia, additional, Fuentealba, Jose, additional, Gallardo, Karina Beatriz, additional, Garcia, Celso, additional, Garcia Duran, Ruben, additional, Garrido, Marcelo, additional, Gavicola, Rodolfo, additional, Gerbaudo, Claudio, additional, Gilli, Graciela, additional, Giotto, Ana Paula, additional, Godoy Bolzán, Pedro, additional, Gomez Vilamajo, Oscar, additional, Guerlloy, Fernando, additional, Guridi, Cristian, additional, Gutierrez Garrido, Narcisa, additional, Hasbani, Eduardo, additional, Hermida, Sonia, additional, Hominal, Miguel, additional, Hrabar, Adrian, additional, Ingaramo, Adrián, additional, Izzicupo, Alejandra, additional, Krynski, Mario, additional, Lagrutta, Mariana, additional, Lanchiotti, Paulina, additional, Langhe, Maria, additional, Leonard, Veronica, additional, Llanos, Javier, additional, Lopez Santi, Ricardo, additional, Lowenstein, Jorge, additional, Luquez, Cecilia, additional, Mackinnon, Ignacio, additional, Mana, Melina, additional, Manzur, Sara, additional, Marino, Javier, additional, Martella, Carolina, additional, Martinez, Roger, additional, Matias, Re, additional, Matkovich, Javier, additional, Meritano, Monica, additional, Montaña, Oscar, additional, Mulazzi, María, additional, Ochoa, Juan, additional, Paterlini, Gustavo, additional, Pelagagge, María, additional, Peralta Lopez, Maria Elena, additional, Prado, Aldo, additional, Pruyas, Lorena, additional, Racca, Martín, additional, Ricotti, Carola, additional, Rodriguez, Carolina, additional, Romero Vidomlansky, Mariano, additional, Ronderos, Ricardo, additional, Sadowski, Ana Laura, additional, Sala, Jorgelina, additional, Sánchez, Alejandro, additional, Santoro, Andrea, additional, Schiavi, Lilia, additional, Sein, Mariano, additional, Sernia, Virginia, additional, Serra, Leonardo, additional, Sicer, Maximiliano, additional, Smith, Tomas, additional, Soso, Leonardo, additional, Sposetti, Georgina, additional, Steinacher, Andrea, additional, Stival, Jorge, additional, Tedesco, Jorge, additional, Tonin, Hugo, additional, Tortolo, Mauro, additional, Ulla, Maria, additional, Vallejos, Julio, additional, Vico, Marisa, additional, Virgillito, Luciana, additional, Visco, Virginia, additional, Vogel, Daniel, additional, Waisman, Florencia, additional, Zaidman, César, additional, Zucchiatti, Noemi, additional, Badshah, Imran, additional, Cohen, Neale, additional, Colman, Peter, additional, Colquhoun, David, additional, Davis, Timothy, additional, Fourlanos, Spiros, additional, Fulcher, Greg, additional, Hamlyn, Jane, additional, Haywood, Cilla, additional, Hocking, Samantha, additional, Huchinson, Maeve, additional, Jeffries, William, additional, Kyl, Mervyn, additional, Lo, Clement, additional, Mah, PeakMann, additional, Makepeace, Ashley, additional, Marope, Dolly, additional, Nanayakkar, Natalie, additional, Nankervis, Alison, additional, Palmer, Neil, additional, Palolus, Barbara, additional, Pillai, Satish, additional, Price, Sarah, additional, Proietto, Joseph, additional, Reutens, Anne, additional, Rodrigo, Natassia, additional, Sheikh, Abdul, additional, Smith, Greg, additional, So, Michelle, additional, Soldatos, Georgia, additional, Stuckey, Bronwyn, additional, Sumithran, Priya, additional, Teede, Helena, additional, Vora, Parind, additional, Williams, Lyn, additional, Abib, Eduardo, additional, Adão Poço, Christiani, additional, Alves, Érica Ferreira, additional, Andreatta Bernardi Barea, Janaina, additional, Avezum Oliveira, Livia, additional, Castro, Denise Ludovico da Costa de, additional, Correa da Cruz, Ivan, additional, Costa, Midiã, additional, Cruz, Ivan, additional, Cunha, Sidney, additional, Da Silva, Marco Antonio Vieira, additional, de Carvalho Camara Bona, Renata, additional, de Paula, Bruna, additional, Eliaschewitz, Freddy, additional, Fazolli, Guilherme, additional, Ferreira Filho, Carlos Alberto, additional, Fortes, Jose, additional, França, Cesar, additional, Franco, Denise Reis, additional, Genestreti, Paulo Roberto, additional, Giorgeto, Flavio, additional, Gonçalves, Rodrigo Marques, additional, Grossman, Michele Elka, additional, Henrique Marcelino, Ana Claudia, additional, Hernandes, Mauro, additional, Horta, Ana, additional, Jaeger, Cristiano, additional, Kaneblai, Midia, additional, Kauffman Rutenberg, Cecilia, additional, Kerr Saraiva, Jose Francisco, additional, Lemos, Maria Angelica, additional, Maia, Lilia, additional, Manenti, Euler Roberto, additional, Marques, Mariana, additional, Melissa Valerio, Cynthia, additional, Moreira, Rodrigo, additional, Mothé, Flávia, additional, Mouco, Osana Maria, additional, Moura, Philip, additional, Moura Jorge, José Carlos, additional, Nakashima, Carlos, additional, Nakazone, Marcelo, additional, Napoli, Thiago, additional, Nunes, Cristiane, additional, Nunes Salles, Joao Eduardo, additional, Oliveira, Karla, additional, Oliveira, Marcela, additional, Pantano, Gracielly de Souza, additional, Petri, Fabio, additional, Piazza, Leonardo, additional, Pires, Andreia Carla, additional, Pizzato, Patricia, additional, Prata, Sergio, additional, Precoma, Dalton, additional, Rech, Rafael, additional, Reis, Gilmar, additional, Reis, Heleno, additional, Resende, Elisabete, additional, Ribas Fortes, Jose, additional, Rodovalho, Sylka, additional, Rossi dos Santos, Fabio, additional, Salles, Joao Eduardo, additional, Sampaio, Célia Regina, additional, Santos, Thiago, additional, Santos dos Santos, Vanessa, additional, Silva e Quadros, Tulio, additional, Silveira, Daniel, additional, Siqueira, Katia Nunes, additional, Teireira, M, additional, Uehara, Marcelo, additional, Valerio, C, additional, Vianna, Henrique, additional, Vidotti, Maria Helena, additional, Visconti, Guilherme de Lima, additional, Zanella, Maria Teresa, additional, Andreeva, Viktoriya, additional, Borisov, Radoslav, additional, Botushanov, Nikolay, additional, Dimitrov, Georgi, additional, Dimova, Kameliya, additional, Dragoychev, Tsvetan, additional, Grigorova, Valentina, additional, Gushterova, Valentina, additional, Ivanov, Ivaylo, additional, Kocelova, Tatyana, additional, Kurktschiev, Dimo, additional, Miletieva, Milena, additional, Nenkova-Gugusheva, Neli, additional, Pancheva, Ralitsa, additional, Pavlova, Maria, additional, Raev, Dimitar, additional, Spasova, Vesela, additional, Stoikov, Anastas, additional, Troev, Dimitar, additional, Yanev, Todor, additional, Yoncheva-Mihaylova, Mariana, additional, Abitbol, Alexander, additional, Ajala, Buki, additional, Alguwaihes, Abdullh, additional, Ardilouze, Jean-Luc, additional, Aris-Jilwan, Nahla, additional, Arnaout, Amel, additional, Aronson, Ronnie, additional, Aslam, Nadeem, additional, Babin, Sandra, additional, Bailargeon, Jean-Patrice, additional, Bailey, Allan, additional, Bajaj, Harpreet, additional, Beauchesne, Christian, additional, Beca, Sorin, additional, Belanger, Andre, additional, Bell, Alan, additional, Bellabarba, Diego, additional, Berard, Lori, additional, Berenbaum, Brian, additional, Bergeron, Vincent, additional, Berlingieri, Joseph, additional, Bernier, Frédéric, additional, Bishara, Phoebe, additional, Blank, David, additional, Blumer, Ian, additional, Brault, Suzanne, additional, Breton, Donald, additional, Carpentier, André, additional, Cha, James, additional, Chandra, Prakash, additional, Chiasson, Jean-Louis, additional, Conway, James R, additional, Couture, Ghyslaine, additional, Couture, Nathalie, additional, Dagenais, Gilles, additional, Datta, Dyotirmoy, additional, D'Ignazio, Giuseppe, additional, Dumas, Richard, additional, Fay, Didier, additional, Frechette, Andre, additional, Frenette, Louise, additional, Fung, Daisy, additional, Gagnon, Nathalie, additional, Galter, Meri, additional, Garon, Jean, additional, Gauthier, Jean Sebastien, additional, Geadah, Christian, additional, Gilbert, Jeremy, additional, Girard, Ronald, additional, Goldenberg, Ronald, additional, Grossman, Loren David, additional, Gupta, Nikhil, additional, Halle, Jean-Pierre, additional, Hivert, Marie-France, additional, Houde, Ghislaine, additional, Houlden, Robyn, additional, Hramiak, Irene, additional, Jablonski, Ted, additional, Jain, Akshay Jain, additional, Khandwala, Hasnain, additional, Khosla, Munish, additional, Lachance, C, additional, Laflamme, Emilie, additional, Langlois, Marie-France, additional, Larivee, Luc, additional, Liutkus, Joanne, additional, Lochnan, Heather, additional, Malik, Saleem, additional, McDonald, Charlotte, additional, Mehta, Pravinsagar, additional, Mihailidis, John, additional, Milot, Alain, additional, Narula, Priya, additional, Nault, Patrice, additional, Nayar, Arun, additional, Nisker, William, additional, Ouellet, Gilles, additional, Palardy, Jean, additional, Patel, Minta, additional, Paul, Terri, additional, Pedersen, Sue, additional, Perron, Patrice, additional, Pesant, Marie-Hélène, additional, Poirier, Paul, additional, Poulin, Marie-Claude, additional, Punthakee, Zubin, additional, Rehman, Waheed, additional, Ross, Stuart, additional, Sagar, P, additional, Saliba, Nouhad, additional, Sandler, Sam, additional, Schiffrin, Alicia, additional, Schlosser, Robert, additional, Seth-Sharma, Anila, additional, Sherman, Mark, additional, Sionit, David, additional, Sivakumar, Tharsan, additional, Soto, Juan, additional, St-Amour, Eric, additional, Steen, Oren, additional, Sussman, Jack, additional, Telner, Adam, additional, Tobe, Sheldon, additional, Twum-Barima, David-Yaw, additional, Van Zanten, Audrey, additional, VanRossum, Nicole, additional, Vecchiarelli, Jonathan, additional, Ward, Rick, additional, Wessengel, John, additional, Weisnagel, Stanley, additional, Wilderman, Igor, additional, Woo, Vincent, additional, Yakubovich, Natalia, additional, Yale, Jean-Francois, additional, Yared, Zeina, additional, Acevedo, Monica, additional, Aguirre, Maria Loreto, additional, Aizman, Andres, additional, Barroso, Maria Soledad, additional, Cobos, Leonardo, additional, Danin Vargas, Alfredo, additional, Descalzi, Barbara, additional, Godoy, Gonzalo, additional, Grumberg, Elio, additional, Lahsen, Rodolfo, additional, Larenas, Gladys, additional, Ortiz, Eugenia, additional, Paredes, Javier, additional, Potthoff, Sergio, additional, Retamal, Eva, additional, Rojas, Luis, additional, Salgado, Manuel, additional, Santibanez, Claudio, additional, Solis, Carmen, additional, Stokins, Benjamin, additional, Accini, Jose, additional, Acebedo, Javier, additional, Agudelo Baena, Lina Maria, additional, Alarcon, Soraya, additional, Angel, Juliana, additional, Arcos, Edgar, additional, Aroca Martinez, M, additional, Atuesta, Leonor, additional, Balaguera, Jose, additional, Ballestas, Doris, additional, Barrera, Sandra Isabel, additional, Barrios Reyes, Rosmy, additional, Bayona, Adolfo, additional, Bermudez, Andres, additional, Bernal, Diego Zarate, additional, Blanquicett, Marco, additional, Bravo, Victor, additional, Bueno, Wendy, additional, Burbano Delgado, Alvaro, additional, Cadena, Alberto, additional, Cadena, Andres, additional, Caicedo, Sandra, additional, Celemin, Carlos, additional, Consuegra, Ricardo, additional, Contreras Pimienta, Cristhian, additional, Corredor, Kelly Johenis, additional, Cure, Carlos, additional, De La Hoz Rueda, Lizeth Dayana, additional, Delgado, Erika, additional, Diaz, Sarahy, additional, Diego, Marta, additional, Donado, Anabell, additional, Encinales Sanabria, William, additional, Escobar, Juliana, additional, Escorcia, Gillian, additional, Forero, Leonardo, additional, Fuentes, Laura, additional, Garcia, Maria, additional, Garcia Lozada, Henry, additional, Garcia Ortiz, Luis, additional, Giraldo, Angela, additional, Gomez Gonzalez, Laura, additional, Granada, Javier, additional, Gutierrez, Corina, additional, Henao, Natalia, additional, Hernandez, Edwin, additional, Herrera Uejbe, Olga Maria, additional, Higuera Cobos, Juan Diego, additional, Ibarra Gómez, Jaime, additional, Jaimes, Edwin Hernandez, additional, Jaramillo, Monica, additional, Jaramillo, Nicolas, additional, Jaramillo Gomez, Carlos, additional, Jaramillo Sanchez, Monica, additional, Jarava Durán, Ivonne, additional, Lopez Ceballos, Catalina, additional, Madrid, Claudia, additional, María Amastha, Elias, additional, Mercado, Jennifer, additional, Molina, Dora Ines, additional, Molina Soto, Jessica, additional, Montoya, Carlos, additional, Morales, Alexander, additional, Muñoz, Carolina, additional, Orozco, Luis Alejandro, additional, Osorio, Oscar, additional, Palmera Sanchez, Jorge Mario, additional, Peña, Adwar, additional, Perez, Jose, additional, Perez Agudelo, Juan, additional, Pérez Amador, Germán, additional, Pertuz, Carlos, additional, Posada, Irina, additional, Puerta, Carlos, additional, Quintero, Adalberto, additional, Quiroz, Diana, additional, Rendon, Carmen, additional, Reyes, Alberto, additional, Reyes, Alvaro, additional, Ripoll, Diana, additional, Rivera, Carlos, additional, Rocha, Maria, additional, Rodriguez, Jose F, additional, Rodriguez Villanueva, Kervis Asid, additional, Rodriguez Zabala, Javier Emilio, additional, Rojas, Sindy, additional, Romero, Maria, additional, Rosero, Ricardo, additional, Rosillo Cardenas, Angelica Rocio, additional, Rueda, Lina, additional, Sanchez, Gregorio, additional, Sanchez, Tatiana, additional, Sotomayor Herazo, Arístides, additional, Suarez, Monica, additional, Torres, Mariana, additional, Trujillo, Freddy, additional, Urina, Miguel, additional, Van Strahlen, Lazaro, additional, Velandia, Carlos, additional, Velasquez Guzman, Carolina, additional, Velazquez, Elizabeth, additional, Vidal Prada, Tatiana, additional, Yepez Alvaran, Juan Pablo, additional, Zarate, Diego, additional, Andelova, Jana, additional, Benesova, Radka, additional, Buzova, Barbara, additional, Cech, Vladimir, additional, Chodova, Ida, additional, Choura, Miroslav, additional, Dufka, Antonin, additional, Gamova, Andrea, additional, Gorgol, Jakub, additional, Hala, Tomas, additional, Havlova, Hana, additional, Hlavkova, Dagmar, additional, Horanska, Petra, additional, Ilcisin-Valova, Juliana, additional, Jenickova, Petra, additional, Jerabek, Ondrej, additional, Kantorova, Ilona, additional, Kolomaznikova, Katerina, additional, Kopeckova, Iva, additional, Kopeckova, Miroslava, additional, Linhart, Karel, additional, Linhart, Tomas, additional, Malecha, Jan, additional, Malicherova, Emilia, additional, Neubauerova, Dana, additional, Oznerova, Martina, additional, Partys, Radan, additional, Pederzoliova, Eva, additional, Petrusova, Maria, additional, Prymkova, Vera, additional, Racicka, Eva, additional, Reissova, Ida, additional, Roderova, Eva, additional, Stanek, Libor, additional, Striova, Alena, additional, Svarcova, Dana, additional, Svoboda, Petr, additional, Szeghy Malicharova, Emilia, additional, Urge, Jan, additional, Vesely, Ladislav, additional, Wasserburger, Bedich, additional, Wasserburgerova, Hilde, additional, Zahumensky, Emil, additional, Zamrazil, Vaclav, additional, Alawi, Hasan, additional, Anastasiadis, Ernestos, additional, Axthelm, Elisabeth, additional, Bieler, Tasso, additional, Buhrig, Christina, additional, Degtyareva, Elizaveta, additional, Dellanna, Frank, additional, Derwahl, Karl-Michael, additional, Diessel, Stephan, additional, Dogiami, Barbara, additional, Dorn-Weitzel, Kirsten, additional, Ernst, Monika, additional, Faulmann, Grit, additional, Fetscher, Baerbel, additional, Forst, Thomas, additional, Freyer-Lahres, Gabriele, additional, Funke, Klaus, additional, Ganz, Xenia, additional, Gleixner, Christiane, additional, Hanefeld, Christoph, additional, Heinrichs, Sven, additional, Helleberg, Stephanie, additional, Henkel, Elena, additional, Hetzel, Gerd Ruediger, additional, Hoffmann, Caren, additional, Jacob, Frohmut, additional, Jacob, Stephan, additional, John, Franziska, additional, Jonczyk, Antonius, additional, Kamke, Wolfram, additional, Klein, Christiane, additional, Kleinhardt, Martina, additional, Kleophas, Werner, additional, Kosch, Christine, additional, Kreutzmann, Kristin, additional, Kühn, Achim, additional, Lee-Barkey, Young Hee, additional, Lier, Alexander, additional, Maatouk, Sarah, additional, Minnich, Joachim, additional, Mitry, Michael, additional, Muessig, Ilona, additional, Nicula, Diana, additional, Niemann, Martina, additional, Nothroff, Joerg, additional, Ott, Petra, additional, Pfuetzner, Andreas, additional, Pfützner, Andreas, additional, Pistrosch, Frank, additional, Pohl, Wildgard, additional, Prochazkova, Zdenka, additional, Retkowska, Marlena, additional, Rosin, Heiko, additional, Sachsenheimer, Daniela, additional, Samer, Holger, additional, Sanuri, Mazin, additional, Schaefer, Axel, additional, Schaper, Frank, additional, Schulze, Erik-Delf, additional, Schulze, Marita, additional, Schumann, Martina, additional, Segiet, Thomas, additional, Sowa, Veronika, additional, Stahl, Hans-Detlev, additional, Steinfeldt, Franziska, additional, Teige, Madlen, additional, Trieb, Bjoern, additional, Tschoepe, Diethelm, additional, Uebel, Peter, additional, Warken, Bernd, additional, Weigmann, Ingo, additional, Weyland, Klaus, additional, Wilhelm, Klara, additional, Balo, Timea, additional, Balsay, Miklos, additional, Bende, Ilona, additional, Bezzegh, Katalin, additional, Birkus, Zita, additional, Buday, Barbara, additional, Csomai, Melinda, additional, Deak, Laszlo, additional, Dezso, Eniko, additional, Faludi, Peter, additional, Faluvegi, M, additional, Fazekas, Ilona, additional, Feher, Agota, additional, Fejer, Csaba, additional, Finta, Ervin, additional, Fulcz, Agnes, additional, Gaal, Zsolt, additional, Gurzo, Mihaly, additional, Hati, Krisztina, additional, Herczeg, Gabriella, additional, Jozsef, Ildiko, additional, Juhasz, Marta, additional, Keltai, Katalin, additional, Koranyi, Laszlo, additional, Kulcsar, Eniko, additional, Kun, Krisztina, additional, Laczko, Andrea, additional, Literáti-Nagy, Botond, additional, Mezo, Izabella, additional, Mileder, Margit, additional, Moricz, I, additional, Nagy, Károly, additional, Nagybaczoni, Bela, additional, Nemeth, Csaba, additional, Oze, Agnes, additional, Pauer, Jozsef, additional, Peterfai, Eva, additional, Polocsanyi, Bela, additional, Poor, Ferenc, additional, Reiber, István, additional, Salamon, Csaba, additional, Sebestyen, Julia, additional, Torok, Ildiko, additional, Tuu, Marianna, additional, Varga, Andrea, additional, Vass, Viktor, additional, Ahn, Chul Min, additional, Ahn, Chulwoo, additional, ByungWon, Park, additional, Chang, Hyuk-Jae, additional, Chang, Kiyuk, additional, Choi, Eui-Young, additional, Choi, Han Seok, additional, Chung, Jin-Wook, additional, Hong, Bum- Kee, additional, Hong, Young Joon, additional, Hyon, Min Su, additional, Jeong, Myung Ho, additional, Kang, Shinae, additional, Kim, Byeong-Keuk, additional, Kim, Ji-Hyun, additional, Kim, Ju Han, additional, Kim, Kee-Sik, additional, Kim, Moo Hyun, additional, Kim, Pum-Joon, additional, Kim, Soon-Kil, additional, Kim, Yong-Seok, additional, Kim, Young Kwon, additional, Koh, Yoon Seok, additional, Kwon, Hyuck Moon, additional, Lee, Byoung Kwon, additional, Lee, Byung-Wan, additional, Lee, Jin Bae, additional, Lee, Myoung-Mook, additional, Lim, Young-Mee, additional, Min, Pil Ki, additional, Park, Jong Sung, additional, Park, Jongsuk, additional, Park, Keun Ho, additional, Park, Sungha, additional, Pyun, Wook Bum, additional, Rim, Se Joong, additional, Ryu, Dong-Ryeol, additional, Seo, Hong-Seog, additional, Seung, Ki Bae, additional, Shin, Dong-Ho, additional, Sim, Doo Sun, additional, Yoon, Young Won, additional, Andersone, Ilze, additional, Babicka, Kristine, additional, Balcere, Inga, additional, Barons, Roberts, additional, Capkovska, Inguna, additional, Geldnere, Kristine, additional, Grigane, Inese, additional, Jegere, Baiba, additional, Lagzdina, Ilze, additional, Mora, Lija, additional, Pastare, Sigita, additional, Ritenberga, Rota, additional, Romanova, Janina, additional, Saknite, Inta, additional, Sidlovska, Natalja, additional, Sokolova, Jelena, additional, Steina, Sandra, additional, Strizko, Iveta, additional, Teterovska, Dace, additional, Vizina, Brigita, additional, Barsiene, Lina, additional, Belozariene, Gintare, additional, Daugintyte-Petrusiene, Laura, additional, Drungiliene, Nijole, additional, Garsviene, Nijole, additional, Grigiene, Ala, additional, Grizas, Vytautas, additional, Jociene, Virginija, additional, Kalvaitiene, Dalia, additional, Kaupiene, Jugeta, additional, Kavaliauskiene, Jurate, additional, Kozloviene, Dalia, additional, Lapteva, Ilona, additional, Maneikiene, Birute, additional, Marcinkeviciene, Jolanta, additional, Markauskiene, Vaidilija, additional, Meiluniene, Salomeja, additional, Norkus, Almantas, additional, Norviliene, Rita, additional, Petrenko, Vladimiras, additional, Radzeviciene, Ruta, additional, Sakalyte, Gintare, additional, Urbonas, Gediminas, additional, Urbutiene, Skaiste, additional, Vasiliauskas, Donatas, additional, Velickiene, Dzilda, additional, Aguilar, Carlos, additional, Alcocer, Marco, additional, Avalos-Ramirez, Juan Antonio, additional, Banda-Elizondo, Ramiro, additional, Bricio-Ramirez, Rubria, additional, Cardenas Mejia, Karla, additional, Cavazos, Francisco, additional, Chapa, Jesus, additional, Cienfuegos, Erika, additional, De la Peña, Astrid, additional, de la Peña Topete, Gilberto, additional, De los Rios Ibarra, Manuel Odin, additional, Elias, Daniel, additional, Flores-Moreno, Claudia, additional, Garcia Hernandez, Pedro, additional, Gonzalez, Luis Gerardo, additional, Guerra Moya, Rosa Linda, additional, Guerra-Lopez, Arturo, additional, Hernandez Baylon, Raymundo, additional, Herrera Colorado, Carolina, additional, Herrera-Marmolejo, Marisol, additional, Islas-Palacios, Neri, additional, Lopez, Esteban, additional, Lopez, Fernando, additional, Lopez Alvarado, Agustin, additional, Luna Ceballos, Rosa Isela, additional, Morales Villegas, Enrique, additional, Moreno-Virgen, Gualberto, additional, Parra Perez, Rosa Linda, additional, Pascoe Gonzalez, Sara, additional, Peralta-Cantu, Irving, additional, Previn, Roopa, additional, Ramirez, Rosa, additional, Ramirez, Rubria, additional, Ramos Zavala, Maria Guadalupe, additional, Rodriguez, Monica, additional, Salgado-Sedano, Rocio, additional, Sanchez-Aguilar, Ana Claudia, additional, Santa Rosa Franco, Edith, additional, Sauque-Reyna, Leobardo, additional, Suarez Otero, Rodrigo, additional, Torres, Ivonne, additional, Velarde-Harnandez, Enrique, additional, Villagordoa, Juan, additional, Villeda-Espinoza, Efrain, additional, Vital-Lopez, Jorge, additional, Zavala- Bello, Cristian Jair, additional, Baker, John, additional, Barrington-Ward, Elaine, additional, Brownless, Thomas, additional, Carroll, Richard, additional, Carson, Simon, additional, Choe, Michelle, additional, Corin, Andrew, additional, Corley, Brian, additional, Cutfield, Richard, additional, Dalaman, Neelam, additional, Dixon, Paul, additional, Drury, Paul, additional, Dyson, Keith, additional, Florkowski, Chris, additional, Ford, Monica, additional, Frengley, William, additional, Helm, Colin, additional, Katzen, Colin, additional, Kerr, Jane, additional, Khanolkar, Manish, additional, Kim, David, additional, Koops, Renata, additional, Krebs, Jeremy, additional, Leikis, Robert, additional, Low, Kwan, additional, Luckey, Alison, additional, Luke, Richard, additional, Macaulay, Susan, additional, Marks, Rodney, additional, McNamara, Catherine, additional, Millar-Coote, Dean, additional, Miller, Steven, additional, Mottershead, Naomi, additional, Reid, James, additional, Robertson, Narcisa, additional, Rosen, Ian, additional, Rowe, David, additional, Schmiedel, Ole, additional, Scott, Russell, additional, Sebastian, Jeffrey, additional, Sheahan, Davitt, additional, Stiebel, Victoria, additional, Ternouth, Ian, additional, Tofield, Chris, additional, Venter, Dirk, additional, Williams, Michael, additional, Williams, Miles, additional, Wu, Fiona, additional, Young, Simon, additional, Arciszewska, Malgorzata, additional, Bochenek, Anna, additional, Borkowski, Piotr, additional, Borowy, Przemyslaw, additional, Chrzanowski, Tomasz, additional, Czerwinski, Edward, additional, Dwojak, Marek, additional, Grodzicka, Agnieszka, additional, Janiec, Izabela, additional, Jaruga, Joanna, additional, Jazwinska-Tarnawska, Ewa Krystyna, additional, Jedynasty, Krystyna, additional, Juzwiak-Czapiewska, Danuta, additional, Karczewicz-Janowska, Jadwiga, additional, Konieczny, Jan, additional, Konieczny, Marek, additional, Korol, Marek, additional, Kozina, Maciej, additional, Krzyzagorska, Ewa, additional, Kucharczyk-Petryka, Ewa, additional, Laz, Roman, additional, Majchrzak, Anna, additional, Mrozowska, Zdzislawa, additional, Mularczyk, Michal, additional, Nowacka, Elzbieta, additional, Peczynska, Jadwiga, additional, Petryka, Robert, additional, Pietrzak, Radoslaw, additional, Pisarczyk-Wiza, Dorota, additional, Rozanska, Aleksandra, additional, Ruzga, Zofia, additional, Rzeszotarska, Emilia, additional, Sacha, Malgorzata, additional, Sekulska, Marzenna, additional, Sidorowicz-Bialynicka, Anna, additional, Stasinska, Teresa, additional, Strzelecka-Sosik, Agnieszka, additional, Swierszcz, Teresa, additional, Szymkowiak, Katarzyna Miroslawa, additional, Turowska, Olga, additional, Wisniewska, Krystyna, additional, Wiza, Maciej, additional, Wozniak, Iwona, additional, Zelazowska, Katarzyna, additional, Ziolkowska-Gawron, Bernadetta, additional, Zytkiewicz-Jaruga, Danuta, additional, Albota, Adrian, additional, Alexandru, Carmina, additional, Avram, Rodica, additional, Bala, Cornelia, additional, Barbonta, Diana, additional, Barbu, Roxana, additional, Braicu, Daniela, additional, Calutiu, Nicoleta, additional, Catrinoiu, Doina, additional, Cerghizan, Anca, additional, Ciorba, Alina, additional, Craciun, Anca, additional, Doros, Rodica, additional, Duma, Livia, additional, Dumitrache, Ancuta, additional, Ferariu, Ioana, additional, Ferician Moza, Anca, additional, Ghergan, Alexandrina, additional, Ghise, Gheorghe, additional, Graur, Mariana, additional, Gribovschi, Mihaela, additional, Mihai, Bogdan, additional, Mihalache, Laura, additional, Mihalcea, Madalina, additional, Mindrescu, Nicoleta, additional, Morosanu, Magdalena, additional, Morosoanu, Andrea, additional, Mota, Maria, additional, Moza, Anca, additional, Nafornita, Valerica, additional, Natea, Narcisa, additional, Nicodim, Simona, additional, Nita, Cristina, additional, Onaca, Adriana, additional, Onaca, Mircea, additional, Pop, Cristina, additional, Pop, Lavinia, additional, Popa, Amorin, additional, Popescu, Alexandrina, additional, Pruna, Luchiana, additional, Roman, Gabriela, additional, Rosu, Mihaela, additional, Sima, Alexandra, additional, Sipciu, Doina, additional, Sitterli-Natea, Carmen Narcisa, additional, Szilagyi, Iosif, additional, Tapurica, Minodora, additional, Tase, Adrian, additional, Tutescu, Adriana-Carmen, additional, Vanghelie, Luminita, additional, Verde, Ioana, additional, Vlad, Adrian, additional, Zarnescu, Mihaela, additional, Akhmetov, Roman, additional, Allenova, Irina, additional, Avdeeva, Irina, additional, Baturina, Oksana, additional, Biserova, Irina, additional, Bokovin, Nikolay, additional, Bondar, Irina, additional, Burova, Natalia, additional, Chufeneva, Galina, additional, Chumachek, Elena, additional, Demidova, Marina, additional, Demin, Alexander, additional, Drobysheva, Vera, additional, Egorova, Irina, additional, Esenyan, Lev, additional, Gelig, Ekaterina, additional, Gilyarevsky, Sergey, additional, Golshmid, Maria, additional, Goncharov, Arseniy, additional, Gorbunova, Anastasia, additional, Gordeev, Ivan, additional, Gorelysheva, Vera, additional, Goryunova, Tatiana, additional, Grebenshchikova, Irina, additional, Ilchenko, Roman, additional, Ivannikova, Maria, additional, Karabalieva, Saule, additional, Karpeeva, Juliya, additional, Khaykina, Elena, additional, Kobalava, Zhanna, additional, Kononenko, Irina, additional, Korolik, Oxana, additional, Korshunova, Anna, additional, Kostenko, Victor, additional, Krasnopevtseva, Irina, additional, Krylova, Ludmila, additional, Kulkova, Polina, additional, Kuzmina, Irina, additional, Ledyaeva, Alla, additional, Levashov, Sergey, additional, Lokhovinina, Natalia, additional, Lvov, Vadim, additional, Martirosyan, Narine, additional, Nedogoda, Sergey, additional, Nilk, Rostislav, additional, Osmolovskaya, Yulia, additional, Panov, Alexey, additional, Paramonova, Olga, additional, Pavlova, Ekaterina, additional, Pekareva, Elena, additional, Petunina, Nina, additional, Ponamareva, Svetlana, additional, Reshedko, Galina, additional, Salasyuk, Alla, additional, Sepkhanyan, Malvina, additional, Serebrov, Alexandr, additional, Shabelnikova, Olesya, additional, Skvortsov, Andrey, additional, Smirnova, Olga, additional, Spiridonova, Oxana, additional, Strogova, Svetlana, additional, Taratukhin, Evgeny, additional, Tereschenko, Sergey, additional, Trukhina, Lubov, additional, Tsarkova, Olga, additional, Tsoma, Vera, additional, Tumarov, Farid, additional, Tyan, Natalya, additional, Tyurina, Tatiana, additional, Villevalde, Svetlana, additional, Yankovaya, Elena, additional, Zarutskaya, Ludmila, additional, Zenkova, Elena, additional, Badat, Aysha, additional, Bester, Frederik, additional, Blignaut, Suzanne, additional, Blom, Dirk, additional, Booysen, Susan, additional, Boyd, Warren, additional, Brice, Brigitte, additional, Brown, Susan, additional, Burgess, Lesley, additional, Cawood, Reina, additional, Coetzee, Kathleen, additional, Conradie, Hillet, additional, Cronje, Tanja, additional, de Jong, Douwe, additional, Ellis, Graham, additional, Emanuel, Shaunagh, additional, Engelbrecht, Ingrid, additional, Foulkes, Sharne, additional, Fourie, Done, additional, Gibson, Gilbert, additional, Govender, Thirumani, additional, Hansa, Sumayah, additional, Hemus, Allana Colleen, additional, Hendricks, Firzana, additional, Heradien, Marshall, additional, Holmgren, Chantelle, additional, Hoosain, Zaheer, additional, Horak, Emile, additional, Howard, Johannes, additional, Immink, Ignatius, additional, Janari, E., additional, Jivan, Daksha, additional, Klusmann, Karl, additional, Labuschagne, Weik, additional, Lai, Yen-yu, additional, Latiff, Gulam, additional, Lombaard, J., additional, Lottering, Hanlie, additional, Meeding, Ronel, additional, Middlemost, Shirley, additional, Mitha, Haroon, additional, Mitha, Ismail, additional, Mkhwanazi, Sandile, additional, Moodley, Rajendran, additional, Murray, Almeri, additional, Musungaie, Dany, additional, Osman, Yasmin, additional, Peacey, Kirsten, additional, Pillay-Ramaya, Larisha, additional, Pretorius, Catharina, additional, Prozesky, Hans, additional, Sarvan, Mahomed, additional, Scholtz, E, additional, Sebesteny, Attila, additional, Skinner, Bianca, additional, Skriker, Michael, additional, Smit, M, additional, Stapelberg, Anna-Marie, additional, Swanepoel, Nicolaas, additional, Urbach, Dorothea, additional, van Aswegen, Dina, additional, van Zyl, Francois, additional, Van Zyl, Louis, additional, Venter, Esme, additional, Wadvalla, Shahid, additional, Wing, Jeffrey, additional, Wolmarans, Karen, additional, Abreu, Cristina, additional, Aguilà, Pilar, additional, Aguilera, Eva, additional, Alonso, Nuria, additional, Alvarez, Carmen, additional, Cajas, Priscila, additional, Castro, Jose Carlos, additional, Codinachs, Roger, additional, Contreras, Jose, additional, Coves, Maria Jose, additional, Fajardo, Carmen, additional, Ferrer, Juan Carlos, additional, Font, Neus, additional, Garcia, Mar, additional, Gil, Maria Apolonia, additional, Gomez, Fernando, additional, Gomez, Lluis Alberto, additional, Gonzalbez, Jose, additional, Griera, Jose Luis, additional, Masmiquel, Luís, additional, Mauricio, Didac, additional, Narejos Perez, Silvia, additional, Nicolau, Juana Ana, additional, Noheda Contreras, Olga, additional, Olivan, Josefina, additional, Olivares, Josefina, additional, Ortega, Emilio, additional, Pellitero, Silvia, additional, Pertusa, Salvador, additional, Rius, Ferran, additional, Rodriguez, Irene, additional, Sánchez-Juan, Carlos, additional, Santos, Dolores, additional, Soldevila, Berta, additional, Subias, David, additional, Terns, Manel, additional, Trescoli, Carlos, additional, Vilaplana, Judith, additional, Villanueva, Alicia, additional, Albo, Jaan, additional, Antus, Kjell, additional, Axelsson, Mattias, additional, Bergström, Lisa, additional, Binsell-Gerdin, Emil, additional, Boman, Kurt, additional, Botond, Fabian, additional, Dotevall, Annika, additional, Graipe, Anna, additional, Jarnet, C, additional, Kaminska, Jessica, additional, Kempe, Anders, additional, Korhonen, Michael, additional, Linderfalk, Carina, additional, Liu, Bo, additional, Ljungstroem, Karl, additional, Ljungström, Karl, additional, Malmqvist, Lennart, additional, Mellbin, Linda, additional, Mooe, Thomas, additional, Nicol, Peter, additional, Norrby, Anders, additional, Ohlsson, Ake, additional, Rosengren, Annika, additional, Saaf, Jan, additional, Salmonsson, Staffan, additional, Strandberg, Olof, additional, Svensson, Karl-Axel, additional, Tengmark, Bengt-Olov, additional, Tsatsaris, Georgios, additional, Ulvenstam, Anders, additional, Vasko, Peter, additional, Chang, Chwen-Tzuei, additional, Chang, Hsin-Mei, additional, Chen, Jung-Fu, additional, Chen, To-Pang, additional, Chung, Ming-Min, additional, Fu, Chia-Po, additional, Hsia, Te-Lin, additional, Hua, Shih-Che, additional, Kuo, Ming-Chun, additional, Lee, Chia-ln, additional, Lee, I-Te, additional, Liang, Kae-Woei, additional, Lin, Shih Yi, additional, Lu, Chieh-Hsiang, additional, Ma, Wen-Ya, additional, Pei, Dee, additional, Shen, Feng-Chih, additional, Su, Ching-Chieh, additional, Su, Shuo-Wei, additional, Tai, Tsai-Sung, additional, Tsai, Wan-Ni, additional, Tsai, Yi-Ting, additional, Tung, Shih-Chen, additional, Wang, Jun-Sing, additional, Yu, Hui-I, additional, Al-Qaissi, Ahmed, additional, Arutchelvam, Vijayaraman, additional, Atkin, Stephen, additional, Au, Simon, additional, Aye, Myint Myint, additional, Bain, Stephen, additional, Bejnariu, Cristina, additional, Bell, Patrick, additional, Bhatnagar, Deepak, additional, Bilous, Rudy, additional, Black, Neil, additional, Brennan, Ursula, additional, Brett, Barbara, additional, Bujanova, Jana, additional, Chow, Elaine, additional, Collier, Andrew, additional, Combe, Amanda, additional, Courtney, Christopher, additional, Courtney, Hamish, additional, Crothers, James, additional, Eavis, Patrick, additional, Elliott, Jackie, additional, Febbraro, Salvatore, additional, Finlayson, Jim, additional, Gandhi, Rajiv, additional, Gillings, Sharon, additional, Hamling, Jonathan, additional, Harper, Roy, additional, Harris, Tim, additional, Hassan, Kahal, additional, Heller, Simon, additional, Jane, Alison, additional, Javed, Zeeshan, additional, Johnson, Tim, additional, Jones, Stephen, additional, Kennedy, Adele, additional, Kerr, David, additional, Kilgallon, Brian, additional, Konya, Judith, additional, Lindsay, John, additional, Lomova-Williams, Lina, additional, Looker, Helen, additional, MacFarlane, David, additional, Macrury, Sandra, additional, Malik, Iqbal, additional, McCrimmon, Rory, additional, McKeith, Douglas, additional, McKnight, John, additional, Mishra, Biswa, additional, Mukhtar, Racha, additional, Mulligan, Ciara, additional, O'Kane, Maurice, additional, Olateju, Tolu, additional, Orpen, Ian, additional, Richardson, Tristan, additional, Rooney, Desmond, additional, Ross, Shorsha Bae, additional, Sathyapalan, Thozhukat, additional, Siddaramaiah, Naveen, additional, Sit, Lee Euan, additional, Stephens, Jeffrey, additional, Turtle, Frances, additional, Wakil, Ammar, additional, Walkinshaw, Emma, additional, Ali, Asem, additional, Anderson, Robert, additional, Arakaki, Richard, additional, Aref, Omar, additional, Ariani, Mehrdad Kevin, additional, Arkin, David, additional, Banarer, Salomon, additional, Barchini, George, additional, Bhan, Arti, additional, Branch, Kelley, additional, Brautigam, Donald, additional, Brietzke, Stephen, additional, Brinas, Maridez, additional, Brito, Yudit, additional, Carter, Casey, additional, Casagni, Kimberely, additional, Casula, Sabina, additional, Chakko, Simon, additional, Charatz, Seth, additional, Childress, Dale, additional, Chow, Lisa, additional, Chustecka, Malgorzata, additional, Clarke, Subha, additional, Cohen, Lisa, additional, Collins, Barry, additional, Colon Vega, Gildred, additional, Comulada-Rivera, Angel, additional, Cortes-Maisonet, Gregorio, additional, Davis, Matthew, additional, de Souza, Jose, additional, Desouza, Cyrus, additional, Dinnan, Mary, additional, Duffy-Hidalgo, Bobbi, additional, Dunn, Barbara, additional, Dunn, Julia, additional, Elman, Marshall, additional, Felicetta, James, additional, Finkelstein, Stuart, additional, Fitz-Patrick, David, additional, Florez, Hermes, additional, Forker, Alan, additional, Fowler, Wayne, additional, Fredrickson, Sonja, additional, Freedman, Zachary, additional, Gainey Narron, Brooke, additional, Gainey-Ferree, Kristin, additional, Gardner, Michael, additional, Gastelum, Christian, additional, Giddings, Stephen, additional, Gillespie, Eve, additional, Gimness, Michael Paul, additional, Goldstein, Gary, additional, Gomes, Maria, additional, Gomez, Nelson, additional, Gorman, Timothy, additional, Goswami, Ketan, additional, Graves, Arthur, additional, Hacking, Scott, additional, Hall, Charles, additional, Hanson, Lenita, additional, Harman, Sherman, additional, Heber, David, additional, Henry, Robert, additional, Hiner, Janette, additional, Hirsch, Irl, additional, Hollander, Priscilla, additional, Hooker, Thomas, additional, Horowitz, Barry, additional, Hoste, Laura, additional, Huang, Loli, additional, Huynh, Minh, additional, Hyman, Dan, additional, Idriss, Soha, additional, Iranmanesh, Ali, additional, Karounos, Dennis, additional, Kashyap, Moti, additional, Katz, Lois, additional, Kaye, William, additional, Khaiton, Yevgeniy, additional, Khardori, Romesh, additional, Kitchen, Timothy, additional, Klein, Andrew, additional, Knffem, Wendi, additional, Kosiborod, Mikhail, additional, Kreglinger, Nicola, additional, Kruger, Davida, additional, Kumar, Anubhav, additional, Laboy, Ivan, additional, Larrabee, Patricia, additional, Larrick, Laura, additional, Lawson, Donna, additional, Ledet, Mike, additional, Lenhard, James, additional, Levy, James, additional, Li, George, additional, Li, Zhaoping, additional, Lieb, David, additional, Limcolioc, April, additional, Lions-Patterson, Jane, additional, Lorber, Daniel, additional, Lorch, Daniel, additional, Lorrello, Michael, additional, Lu, Peter, additional, Lucas, Kathryn Jean, additional, Ma, Siu-Ling, additional, MacAdams, Michael, additional, Magee, Michelle, additional, Magno, Alexander, additional, Mahakala, Aparna Reddy, additional, Marks, Jennifer, additional, McCall, Anthony, additional, McClanahan, William, additional, McClary, Carole, additional, Melendez, Lydia, additional, Melish, John, additional, Michaud, Deanna, additional, Miller, Christopher, additional, Miller, Neil, additional, Mora, Pablo, additional, Moten, Marriyam, additional, Mudaliar, Sunder, additional, Myrick, Gregory, additional, Narayan, Puneet, additional, Nassif, Mike, additional, Neri, Karena, additional, Newton, Tabitha, additional, Niblack, Patricia, additional, Nicol, Philip, additional, Nyenwe, Ebenezer, additional, Odugbesan, A. Ola, additional, Okorocha, Yolanda, additional, Ortiz Carrasquillo, Ramón, additional, Osei, Kwame, additional, Palermo, Coromoto, additional, Patel, Hiren, additional, Patel, Krishna, additional, Pau, Cindy, additional, Perley, Michael, additional, Plevin, Sanford, additional, Plummer, Elena, additional, Powell, Richard, additional, Qintar, Mohammed, additional, Rawls, Rex, additional, Reyes-Castano, John, additional, Reynolds, Lillian, additional, Richards, Robert, additional, Rosenstock, Julio, additional, Rowe, Caroline, additional, Saleh, Jahandar, additional, Sam, Sony, additional, Sanchez, Alfredo, additional, Sander, Donald, additional, Sanderson, Bruce, additional, Savin, Virginia, additional, Seaquist, Elizabeth, additional, Shah, Jayendra, additional, Shi, Serena, additional, Shivaswamy, Vijay, additional, Shlotzhauer, Tammi, additional, Shore, David, additional, Skukowski, Bobbie, additional, Soe, Kyaw, additional, Solheim, Vesna, additional, Soufer, Joseph, additional, Steinberg, Helmut, additional, Steinsapir, Jaime, additional, Tarkington, Phillip, additional, Thayer, Debra, additional, Thomson, Stephen, additional, Thrasher, James, additional, Tibaldi, Joseph, additional, Tjaden, Jeff, additional, Tores, Oberto, additional, Trence, Dace, additional, Trikudanathan, Subbulaxmi, additional, Ullal, Jagdeesh, additional, Uwaifo, Gabriel, additional, Vo, Anthony, additional, Vu, Kenny, additional, Walia, Damandeep, additional, Weiland, Karen, additional, Whitehouse, Fred, additional, Wiegmann, Thomas, additional, Wyne, Kathleen, additional, Wynne, Alan, additional, Yuen, Kevin, additional, Zaretzky, Joel, additional, Zebrack, James, additional, Zieve, Franklin, additional, and Zigrang, William, additional

Published
2019
Full Text
View/download PDF

27. Generalizability of glucagon‐like peptide‐1 receptor agonist cardiovascular outcome trials to the overall type 2 diabetes population in the United States

Author

Boye, Kristina S., primary, Riddle, Matthew C., additional, Gerstein, Hertzel C., additional, Mody, Reema, additional, Garcia‐Perez, Luis‐Emilio, additional, Karanikas, Chrisanthi A., additional, Lage, Maureen J., additional, Riesmeyer, Jeffrey S., additional, and Lakshmanan, Mark C., additional

Published
2019
Full Text
View/download PDF

28. Baseline fasting plasma insulin levels predict risk for major adverse cardiovascular events among patients with diabetes and high-risk vascular disease: Insights from the ACCELERATE trial

Author

Kumar, Anirudh, primary, Patel, Divyang R, additional, Wolski, Kathy E, additional, Lincoff, A Michael, additional, Kashyap, Sangeeta R, additional, Ruotolo, Giacomo, additional, McErlean, Ellen, additional, Weerakkody, Govinda, additional, Riesmeyer, Jeffrey S, additional, Nicholls, Stephen J, additional, Nissen, Steven E, additional, and Menon, Venu, additional

Published
2019
Full Text
View/download PDF

29. ADCY9 Genetic Variants and Cardiovascular Outcomes With Evacetrapib in Patients With High-Risk Vascular Disease

Author

Nissen, Steven E., primary, Pillai, Sreekumar G., additional, Nicholls, Stephen J., additional, Wolski, Kathy, additional, Riesmeyer, Jeffrey S., additional, Weerakkody, Govinda J., additional, Foster, Wendra M., additional, McErlean, Ellen, additional, Li, Lin, additional, Bhatnagar, Pallav, additional, Ruotolo, Giacomo, additional, and Lincoff, A. Michael, additional

Published
2018
Full Text
View/download PDF

32. The Role of Lipoprotein (a) as a Marker of Residual Risk in Patients With Diabetes and Established Cardiovascular Disease on Optimal Medical Therapy: Post Hoc Analysis of ACCELERATE.

Author

Shah, Nishant P., Qiuqing Wang, Wolski, Katherine E., Cho, Leslie, McErlean, Ellen, Ruotolo, Giacomo, Weerakkody, Govinda, Riesmeyer, Jeffrey S., Nicholls, Stephen J., Lincoff, A. Michael, Nissen, Steven E., Menon, Venu, and Wang, Qiuqing

Subjects
PEOPLE with diabetes, CHOLESTERYL ester transfer protein, INCOME tax deductions
Abstract

The article discusses the role of Lipoprotein as a marker of residual risk in patients with diabetes and established cardiovascular disease on optimal medical therapy. Topics discussed including primary end point for this analysis was the first occurrence of any component of the composite cardiovascular death; and adjudicated by a blinded clinical end point committee utilizing prespecified definitions.

Published
2020
Full Text
View/download PDF

34. Acute hemodynamic changes during intravenous dipyridamole thallium imaging early after infarction

Author

Miller, D. Douglas, Scott, Ronald A., Riesmeyer, Jeffrey S., Chaudhuri, Tuhin K., Blumhardt, Ralph, Boucher, Charles A., and O'Rourke, Robert A.

Subjects
Heart attack -- Physiological aspects, Thallium -- Isotopes, Dipyridamole, Health
Abstract

The injection of radioactive thallium-201 can be used to observe the flow of blood through the coronary arteries. The injection of dipyridamole is often used in conjunction with this technique to detect impaired blood flow to the heart muscle past areas of stenosis, or narrowing of the coronary arteries (most often due to atherosclerosis). Narrow segments, which may perform acceptably during normal conditions, may prove inadequate when blood flow increases during stress, and this can be observed using dipyridamole. Although promising, the technique currently remains a subject of investigation, and is not yet routinely used in the evaluation of patients with heart disease. To further evaluate the safety and efficacy of the method, 10 patients recovering from uncomplicated myocardial infarctions (heart attacks) were examined. Three patients developed ischemia (reduced blood supply) and associated angina pectoris (chest pain) during the technique, but the events were not serious. Aminophylline was found to promptly reverse the effects of dipyridamole and return the patient's hemodynamic measurements to baseline. The results confirm that the dipyridamole-thallium imaging technique is effective and safe for patients with myocardial infarction when used in a controlled setting along with aminophylline reversal of the drug effects. However, clinicians should be reminded that there are no data to suggest that the technique is safe for patients with complicated myocardial infarction. In the presence of heart failure, angina, low blood pressure, or ventricular arrhythmias, the technique should be used only with extensive precautions and great care. (Consumer Summary produced by Reliance Medical Information, Inc.)

Published
1989

35. Biomarkers of Hemostatic Activation in a Randomized, Double-Blind, Phase 2 Study of Prasugrel Compared to Placebo in Adults with Sickle Cell Disease

Author

Wun, Ted, primary, Knupp, Charles L., additional, McMahon, Lillian E., additional, Strouse, John J., additional, Zhou, Chunmei, additional, Heath, Lori E., additional, Nwachuku, Chuke E., additional, Jakubowski, Joseph A., additional, Winters, Kenneth J., additional, and Riesmeyer, Jeffrey S., additional

Published
2011
Full Text
View/download PDF

36. A Randomized, Double-Blind, Adaptive Phase 2 Multi-Center Study of Prasugrel Compared to Placebo in Adults with Sickle Cell Disease

Author

Wun, Ted, primary, Soulieres, Denis, additional, Krishnamurti, Lakshmanan, additional, Kutlar, Abdullah, additional, Ataga, Kenneth, additional, Zhou, Chunmei, additional, Heath, Lori E., additional, Nwachuku, Chuke E., additional, Jakubowski, Joseph A., additional, Winters, Kenneth J., additional, and Riesmeyer, Jeffrey S., additional

Published
2011
Full Text
View/download PDF

38. Abstract 4001: Relationship between Exposure to the Prasugrel Active Metabolite with TIMI Major/Minor Bleeding in TRITON-TIMI 38

Author

Salazar, Daniel E, primary, Ernest, C. Steven, additional, Wrishko, Rebecca E, additional, Weerakkody, Govinda J, additional, Small, David S, additional, Li, Ying G, additional, Rhohatagi, Shashank, additional, Dornseif, Bruce E, additional, Ni, Lan, additional, Antman, Elliot M, additional, Wiviott, Stephen D, additional, Macias, William L, additional, and Riesmeyer, Jeffrey S, additional

Published
2008
Full Text
View/download PDF

40. Abstract 14025: Evacetrapib Alone or in Combination With Different Statin Doses Results in Differential Effect on Lipoproteins and MACE Rates: The ACCELERATE Trial.

Author

Riesmeyer, Jeffrey S, Ruotolo, Giacomo, Weerakkody, Govinda, Kathy, Wolski, McErlean, Ellen, Menon, Venu, Lincoff, Michael A, Nissen, Steven E, and Nicholls, Stephen J

Subjects
*LIPOPROTEINS, *LIPOPROTEIN A, *APOLIPOPROTEINS, *IMPACT testing, *MATHEMATICAL combinations, *LIPIDS, *CLINICAL trials
Abstract

Background: Potential benefits of pharmacological CETP inhibition are likely to reflect lowering of apoB-containing lipoproteins as opposed to HDL-C raising. However, genetic studies have shown that there is discordant reduction in LDL-C versus apoB levels when CETP deficiency is combined with HMGCR deficiency. Hypothesis: While small studies have suggested that concomitant statin therapy may potentially adversely modulate the ability of CETP inhibitors to reduce atherogenic lipid parameters, it has not been systematically investigated in large-scale clinical trial of CETP inhibition. Methods: ACCELERATE is a cardiovascular outcomes trial of the effects of evacetrapib versus placebo in high cardiovascular risk patients who are predominantly treated with moderate or high dose statin therapy in accordance with the guidelines (Table). However, 7% of the patients did not tolerate optimal doses and were on either no statin or low dose. We analyzed data from this trial to test impact of statin dose on observed magnitude of placebo-subtracted changes on lipid and apolipoprotein levels, when given in combination with evacetrapib. Results: Placebo-subtracted percent changes from baseline to 1 month in lipids and apolipoproteins are shown in the Table. While the degree of evacetrapib-induced LDL-C reduction was not affected by statin intensity, that of apoB was dose-dependent, with a higher decrease in the group not taking statin. The magnitude of HDL-C and apoA-I increases were also dose-dependent, with a higher increase in the group not taking statin. Evacetrapib-induced increase in apoE was higher in the three statin groups compared to patients not on statin. ApoC-II and apoC-III behaved similarly to apoE, even though the differences were not significant. Hypothesis-generating analysis suggests potential different MACE rates in patients on evacetrapib according to statin intensity (p=0.11). Conclusions: In the ACCELERATE trial, the subset of patients on evacetrapib without added statin had the largest decrease in apoB and increase in HDL-C, and smallest increase in apoE. It remains to be seen if patients on CETP inhibitor monotherapy or on low dose statin could experience lower MACE rates. [ABSTRACT FROM AUTHOR]

Published
2018

42. Comparison of one-year outcomes...ESPRIT. Enhanced Suppression of the Platelet IIb/IIIa Receptor With Integrilin Therapy.

Author

Riesmeyer, Jeffrey S, Reid, Philip R, and Miller, Debra L

Subjects
*CORONARY heart disease complications, *DIABETES complications, *CORONARY disease, *EXPERIMENTAL design, *GLYCOPROTEINS, *PEPTIDES, *STATISTICS, *DATA analysis, *TREATMENT effectiveness, *CHEMICAL inhibitors, *PLATELET aggregation inhibitors, *PHARMACODYNAMICS, *STANDARDS, *THERAPEUTICS
Published
2003
Full Text
View/download PDF

43. Efficacy and Safety of the Cholesteryl Ester Transfer Protein Inhibitor Evacetrapib in Combination With Atorvastatin in Japanese Patients With Primary Hypercholesterolemia.

Author

Teramoto T, Kiyosue A, Iimura T, Takita Y, Riesmeyer JS, and Murakami M

Subjects
Aged, Asian People, Cholesterol Ester Transfer Proteins antagonists & inhibitors, Cholesterol, HDL blood, Cholesterol, HDL drug effects, Cholesterol, LDL blood, Double-Blind Method, Drug Therapy, Combination, Female, Humans, Male, Middle Aged, Treatment Outcome, Atorvastatin administration & dosage, Benzodiazepines administration & dosage, Cholesterol, LDL drug effects
Abstract

Background: Inhibition of cholesteryl ester transfer protein by evacetrapib when added to atorvastatin may provide an additional treatment option for patients who do not reach their low-density lipoprotein cholesterol (LDL-C) goal.Methods and Results:This multicenter, randomized, 12-week, double-blind, parallel-group, placebo-controlled, outpatient, phase 3 study evaluated the efficacy of evacetrapib with atorvastatin in reducing LDL-C in 149 Japanese patients (evacetrapib/atorvastatin, n=53; ezetimibe/atorvastatin, n=50; placebo/atorvastatin, n=46) with primary hypercholesterolemia. The primary efficacy measure was percent change from baseline to week 12 in LDL-C (β quantification). Treatment with evacetrapib 130 mg daily for 12 weeks resulted in a statistically significant treatment difference of -25.70% compared with placebo in percentage decrease in LDL-C (95% CI: -34.73 to -16.68; P<0.001). Treatment with evacetrapib 130 mg also resulted in a statistically significant difference of 126.39% in the change in high-density lipoprotein cholesterol (HDL-C) compared with placebo (95% CI: 113.54-139.24; P<0.001). No deaths or serious adverse events were reported. Four patients (3 in the evacetrapib group and 1 in the ezetimibe group) discontinued due to adverse events., Conclusions: Evacetrapib daily in combination with atorvastatin was superior to placebo in lowering LDL-C after 12 weeks, and resulted in a statistically significant increase of HDL-C compared with placebo. Also, no new safety risks were identified.

Published
2017
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results