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1. Onkologische Therapie

Author

Appold, S., Dörr, W., Folprecht, G., Grötz, K. A., Reiß, G., Reiß, M., Riesenbeck, D., Waldfahrer, F., and Reiß, Michael, editor

Published
2009
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6. DEGRO 2004: 10. Jahreskongress der Deutschen Gesellschaft für Radioonkologie

Author

Wendt, Thomas G., Gademann, G., Pambor, C., Grießbach, I., von Specht, H., Martin, T., Baltas, D., Kurek, R., Röddiger, S., Tunn, U. W., Zamboglou, N., Eich, H. T., Staar, S., Gossmann, A., Hansemann, K., Semrau, R., Skripnitchenko, R., Diehl, V., Müller, R.-P., Sehlen, S., Willich, N., Rühl, U., Lukas, P., Dühmke, E., Engel, K., Tabbert, E., Bolck, M., Knaack, S., Annweiler, H., Krempien, R., Hoppe, H., Harms, W., Daeuber, S., Schorr, O., Treiber, M., Debus, J., Alber, M., Paulsen, F., Birkner, M., Bakai, A., Belka, C., Budach, W., Grosser, K.-H., Kramer, R., Kober, B., Reinert, M., Schneider, P., Hertel, A., Feldmann, H., Csere, P., Hoinkis, C., Rothe, G., Zahn, P., Alheit, H., Cavanaugh, S. X., Kupelian, P., Reddy, C., Pollock, B., Fuss, M., Roeddiger, S., Dannenberg, T., Rogge, B., Drechsler, D., Herrmann, T., Alberti, W., Schwarz, R., Graefen, M., Krüll, A., Rudat, V., Huland, H., Fehr, C., Baum, C., Glocker, S., Nüsslin, F., Heil, T., Lemnitzer, H., Knips, M., Baumgart, O., Thiem, W., Kloetzer, K.-H., Hoffmann, L., Neu, B., Hültenschmidt, B., Sautter-Bihl, M.-L., Micke, O., Seegenschmiedt, M. H., Köppen, D., Klautke, G., Fietkau, R., Schultze, J., Schlichting, G., Koltze, H., Kimmig, B., Glatzel, M., Fröhlich, D., Bäsecke, S., Krauß, A., Strauß, D., Buth, K.-J., Böhme, R., Oehler, W., Bottke, D., Keilholz, U., Heufelder, K., Wiegel, T., Hinkelbein, W., Rödel, C., Papadopoulos, T., Munnes, M., Wirtz, R., Sauer, R., Rödel, F., Lubgan, D., Distel, L., Grabenbauer, G. G., Sak, A., Stüben, G., Pöttgen, C., Grehl, S., Stuschke, M., Müller, K., Pfaffendorf, C., Mayerhofer, A., Köhn, F. M., Ring, J., van Beuningen, D., Meineke, V., Neubauer, S., Keller, U., Wittlinger, M., Riesenbeck, D., Greve, B., Exeler, R., Ibrahim, M., Liebscher, C., Severin, E., Ott, O., Pötter, R., Hammer, J., Hildebrandt, G., Beckmann, M. W., Strnad, V., Fehlauer, F., Tribius, S., Bajrovic, A., Höller, U., Rades, D., Warszawski, A., Baumann, R., Madry-Gevecke, B., Karstens, J. H., Grehn, C., Hensley, F., Berns, C., Wannenmacher, M., Semrau, S., Reimer, T., Gerber, B., Ketterer, P., Koepcke, E., Hänsgen, G., Strauß, H. G., Dunst, J., Füller, J., Kalb, S., Wendt, T., Weitmann, H. D., Waldhäusl, C., Knocke, T.-H., Lamprecht, U., Classen, J., Kaulich, T. W., Aydeniz, B., Bamberg, M., Wiezorek, T., Banz, N., Salz, H., Scheithauer, M., Schwedas, M., Lutterbach, J., Bartelt, S., Frommhold, H., Lambert, J., Hornung, D., Swiderski, S., Walke, M., Siefert, A., Pöllinger, B., Krimmel, K., Schaffer, M., Koelbl, O., Bratengeier, K., Vordermark, D., Flentje, M., Hero, B., Berthold, F., Combs, S. E., Gutwein, S., Schulz-Ertner, D., van Kampen, M., Thilmann, C., Kocher, M., Kunze, S., Schild, S., Ikezaki, K., Müller, B., Sieber, R., Weiß, C., Wolf, I., Wenz, F., Weber, K.-J., Schäfer, J., Engling, A., Laufs, S., Veldwijk, M. R., Milanovic, D., Fleckenstein, K., Zeller, W., Fruehauf, S., Herskind, C., Weinmann, M., Jendrossek, V., Rübe, C., Appold, S., Kusche, S., Hölscher, T., Brüchner, K., Geyer, P., Baumann, M., Kumpf, R., Zimmermann, F., Schill, S., Geinitz, H., Nieder, C., Jeremic, B., Molls, M., Liesenfeld, S., Petrat, H., Hesselmann, S., Schäfer, U., Bruns, F., Horst, E., Wilkowski, R., Assmann, G., Nolte, A., Diebold, J., Löhrs, U., Fritz, P., Hans-Jürgen, K., Mühlnickel, W., Bach, P., Wahlers, B., Kraus, H.-J., Wulf, J., Hädinger, U., Baier, K., Krieger, T., Müller, G., Hof, H., Herfarth, K., Brunner, T., Hahn, S. M., Schreiber, F. S., Rustgi, A. K., McKenna, W. G., Bernhard, E. J., Guckenberger, M., Meyer, K., Willner, J., Schmidt, M., Kolb, M., Li, M., Gong, P., Abdollahi, A., Trinh, T., Huber, P. E., Christiansen, H., Saile, B., Neubauer-Saile, K., Tippelt, S., Rave-Fränk, M., Hermann, R. M., Dudas, J., Hess, C. F., Schmidberger, H., Ramadori, G., Andratschke, N., Price, R., Ang, K.-K., Schwarz, S., Kulka, U., Busch, M., Schlenger, L., Bohsung, J., Eichwurzel, I., Matnjani, G., Sandrock, D., Richter, M., Wurm, R., Budach, V., Feussner, A., Gellermann, J., Jordan, A., Scholz, R., Gneveckow, U., Maier-Hauff, K., Ullrich, R., Wust, P., Felix, R., Waldöfner, N., Seebass, M., Ochel, H.-J., Dani, A., Varkonyi, A., Osvath, M., Szasz, A., Messer, P. M., Blumstein, N. M., Gottfried, H.-W., Schneider, E., Reske, S. N., Röttinger, E. M., Grosu, A.-L., Franz, M., Stärk, S., Weber, W., Heintz, M., Indenkämpen, F., Beyer, T., Lübcke, W., Levegrün, S., Hayen, J., Czech, N., Mbarek, B., Köster, R., Thurmann, H., Todorovic, M., Schuchert, A., Meinertz, T., Münzel, T., Grundtke, H., Hornig, B., Hehr, T., Dilcher, C., Chan, R. C., Mintz, G. S., Kotani, J.-I., Shah, V. M., Canos, D. A., Weissman, N. J., Waksman, R., Wolfram, R., Bürger, B., Schrappe, M., Timmermann, B., Lomax, A., Goitein, G., Schuck, A., Mattke, A., Int-Veen, C., Brecht, I., Bernhard, S., Treuner, J., Koscielniak, E., Heinze, F., Kuhlen, M., von Schorlemer, I., Ahrens, S., Hunold, A., Könemann, S., Winkelmann, W., Jürgens, H., Gerstein, J., Polivka, B., Sykora, K.-W., Bremer, M., Thamm, R., Höpfner, C., Gumprecht, H., Jäger, R., Leonardi, M. A., Frank, A. M., Trappe, A. E., Lumenta, C. B., Östreicher, E., Pinsker, K., Müller, A., Fauser, C., Arnold, W., Henzel, M., Groß, M. W., Engenhart-Cabillic, R., Schüller, P., Palkovic, S., Schröder, J., Wassmann, H., Block, A., Bauer, R., Keffel, F.-W., Theophil, B., Wisser, L., Rogger, M., Niewald, M., van Lengen, V., Mathias, K., Welzel, G., Bohrer, M., Steinvorth, S., Schleußner, C., Leppert, K., Röhrig, B., Strauß, B., van Oorschot, B., Köhler, N., Anselm, R., Winzer, A., Schneider, T., Koch, U., Schönekaes, K., Mücke, R., Büntzel, J., Kisters, K., Scholz, C., Keller, M., Winkler, C., Prause, N., Busch, R., Roth, S., Haas, I., Willers, R., Schultze-Mosgau, S., Wiltfang, J., Kessler, P., Neukam, F. W., Röper, B., Nüse, N., Auer, F., Melzner, W., Geiger, M., Lotter, M., Kuhnt, T., Müller, A. C., Jirsak, N., Gernhardt, C., Schaller, H.-G., Al-Nawas, B., Klein, M. O., Ludwig, C., Körholz, J., Grötz, K. A., Huppers, K., Kunkel, M., Olschewski, T., Bajor, K., Lang, B., Lang, E., Kraus-Tiefenbacher, U., Hofheinz, R., von Gerstenberg-Helldorf, B., Willeke, F., Hochhaus, A., Roebel, M., Oertel, S., Riedl, S., Buechler, M., Foitzik, T., Ludwig, K., Klar, E., Meyer, A., Meier zu Eissen, J., Schwab, D., Meyer, T., Höcht, S., Siegmann, A., Sieker, F., Pigorsch, S., Milicic, B., Acimovic, L., Milisavljevic, S., Radosavljevic-Asic, G., Presselt, N., Baum, R. P., Treutler, D., Bonnet, R., Schmücking, M., Sammour, D., Fink, T., Ficker, J., Pradier, O., Lederer, K., Weiss, E., Hille, A., Welz, S., Sepe, S., Friedel, G., Spengler, W., Susanne, E., Kölbl, O., Hoffmann, W., Wörmann, B., Günther, A., Becker-Schiebe, M., Güttler, J., Schul, C., Nitsche, M., Körner, M. K., Oppenkowski, R., Guntrum, F., Malaimare, L., Raub, M., Schöfl, C., Averbeck, T., Hacker, I., Blank, H., Böhme, C., Imhoff, D., Eberlein, K., Weidauer, S., Böttcher, H. D., Edler, L., Tatagiba, M., Molina, H., Ostertag, C., Milker-Zabel, S., Zabel, A., Schlegel, W., Hartmann, A., Wildfang, I., Kleinert, G., Hamm, K., Reuschel, W., Wehrmann, R., Kneschaurek, P., Münter, M. W., Nikoghosyan, A., Didinger, B., Nill, S., Rhein, B., Küstner, D., Schalldach, U., Eßer, D., Göbel, H., Wördehoff, H., Pachmann, S., Hollenhorst, H., Dederer, K., Evers, C., Lamprecht, J., Dastbaz, A., Schick, B., Fleckenstein, J., Plinkert, P. K., Rübe, Chr., Merz, T., Sommer, B., Mencl, A., Ghilescu, V., Astner, S., Martin, A., Momm, F., Volegova-Neher, N. J., Schulte-Mönting, J., Guttenberger, R., Buchali, A., Blank, E., Sidow, D., Huhnt, W., Gorbatov, T., Heinecke, A., Beckmann, G., Bentia, A.-M., Schmitz, H., Spahn, U., Heyl, V., Prott, P.-J., Galalae, R., Schneider, R., Voith, C., Scheda, A., Hermann, B., Bauer, L., Melchert, F., Kröger, N., Grüneisen, A., Jänicke, F., Zander, A., Zuna, I., Schlöcker, I., Wagner, K., John, E., Dörk, T., Lochhas, G., Houf, M., Lorenz, D., Link, K.-H., Prott, F.-J., Thoma, M., Schauer, R., Heinemann, V., Romano, M., Reiner, M., Quanz, A., Oppitz, U., Bahrehmand, R., Tine, M., Naszaly, A., Patonay, P., Mayer, Á., Markert, K., Mai, S.-K., Lohr, F., Dobler, B., Pinkawa, M., Fischedick, K., Treusacher, P., Cengiz, D., Mager, R., Borchers, H., Jakse, G., Eble, M. J., Asadpour, B., Krenkel, B., Holy, R., Kaplan, Y., Block, T., Czempiel, H., Haverkamp, U., Prümer, B., Christian, T., Benkel, P., Weber, C., Gruber, S., Reimann, P., Blumberg, J., Krause, K., Fischedick, A.-R., Kaube, K., Steckler, K., Henzel, B., Licht, N., Loch, T., Krystek, A., Lilienthal, A., Alfia, H., Claßen, J., Spillner, P., Knutzen, B., Souchon, R., Schulz, I., Grüschow, K., Küchenmeister, U., Vogel, H., Wolff, D., Ramm, U., Licner, J., Rudolf, F., Moog, J., Rahl, C. G., Mose, S., Vorwerk, H., Weiß, E., Engert, A., Seufert, I., Schwab, F., Dahlke, J., Zabelina, T., Krüger, W., Kabisch, H., Platz, V., Wolf, J., Pfistner, B., Stieltjes, B., Wilhelm, T., Schmuecking, M., Junker, K., Treutier, D., Schneider, C. P., Leonhardi, J., Niesen, A., Hoeffken, K., Schmidt, A., Mueller, K.-M., Schmid, I., Lehmann, K., Blumstein, C. G., Kreienberg, R., Freudenberg, L., Kühl, H., Stahl, M., Elo, B., Erichsen, P., Stattaus, H., Welzel, T., Mende, U., Heiland, S., Salter, B. J., Schmid, R., Stratakis, D., Huber, R. M., Haferanke, J., Zöller, N., Henke, M., Lorenzen, J., Grzyska, B., Kuhlmey, A., Adam, G., Hamelmann, V., Bölling, T., Job, H., Panke, J. E., Feyer, P., Püttmann, S., Siekmeyer, B., Jung, H., Gagel, B., Militz, U., Piroth, M., Schmachtenberg, A., Hoelscher, T., Verfaillie, C., Kaminski, B., Lücke, E., Mörtel, H., Eyrich, W., Fritsch, M., Georgi, J.-C., Plathow, C., Zieher, H., Kiessling, F., Peschke, P., Kauczor, H.-U., Licher, J., Schneider, O., Henschler, R., Seidel, C., Kolkmeyer, A., Nguyen, T. P., Janke, K., Michaelis, M., Bischof, M., Stoffregen, C., Lipson, K., Weber, K., Ehemann, V., Jürgen, D., Achanta, P., Thompson, K., Martinez, J. L., Körschgen, T., Pakala, R., Pinnow, E., Hellinga, D., O’Tio, F., Katzer, A., Kaffer, A., Kuechler, A., Steinkirchner, S., Dettmar, N., Cordes, N., Frick, S., Kappler, M., Taubert, H., Bartel, F., Schmidt, H., Bache, M., Frühauf, S., Wenk, T., Litzenberger, K., Erren, M., van Valen, F., Liu, L., Yang, K., Palm, J., Püsken, M., Behe, M., Behr, T. M., Marini, P., Johne, A., Claussen, U., Liehr, T., Steil, V., Moustakis, C., Griessbach, I., Oettel, A., Schaal, C., Reinhold, M., Strasssmann, G., Braun, I., Vacha, P., Richter, D., Osterham, T., Wolf, P., Guenther, G., Miemietz, M., Lazaridis, E. A., Forthuber, B., Sure, M., Klein, J., Saleske, H., Riedel, T., Hirnle, P., Horstmann, G., Schoepgens, H., Van Eck, A., Bundschuh, O., Van Oosterhut, A., Xydis, K., Theodorou, K., Kappas, C., Zurheide, J., Fridtjof, N., Ganswindt, U., Weidner, N., Buchgeister, M., Weigel, B., Müller, S. B., Glashörster, M., Weining, C., Hentschel, B., Sauer, O. A., Kleen, W., Beck, J., Lehmann, D., Ley, S., Fink, C., Puderbach, M., Hosch, W., Schmähl, A., Jung, K., Stoßberg, A., Rolf, E., Damrau, M., Oetzel, D., Maurer, U., Maurer, G., Lang, K., Zumbe, J., Hahm, D., Fees, H., Robrandt, B., Melcher, U., Niemeyer, M., Mondry, A., Kanellopoulos-Niemeyer, V., Karle, H., Jacob-Heutmann, D., Born, C., Mohr, W., Kutzner, J., Thelen, M., Schiebe, M., Pinkert, U., Piasswilm, L., Pohl, F., Garbe, S., Wolf, K., Nour, Y., Barwig, P., Trog, D., Schäfer, C., Herbst, M., Dietl, B., Cartes, M., Schroeder, F., Sigingan-Tek, G., Feierabend, R., Theden, S., Schlieck, A., Gotthardt, M., Glowalla, U., Kremp, S., Hamid, O., Riefenstahl, N., Michaelis, B., Schaal, G., Liebermeister, E., Niewöhner-Desbordes, U., Kowalski, M., Franz, N., Stahl, W., Baumbach, C., Thale, J., Wagner, W., Justus, B., Huston, A. L., Seaborn, R., Rai, P., Rha, S.-W., Sakas, G., Wesarg, S., Zogal, P., Schwald, B., Seibert, H., Berndt-Skorka, R., Seifert, G., Schoenekaes, K., Bilecen, C., Ito, W., Matschuck, G., and Isik, D.

Published
2004
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11. MASCC/ISOO clinical practice guidelines for the management of mucositis secondary to cancer therapy

Author

Lalla, R.V. Bowen, J. Barasch, A. Elting, L. Epstein, J. Keefe, D.M. McGuire, D.B. Migliorati, C. Nicolatou-Galitis, O. Peterson, D.E. Raber-Durlacher, J.E. Sonis, S.T. Elad, S. The Mucositis Guidelines Leadership Group of the Multinational Association of Supportive Care in Cancer International Society of Oral Oncology (MASC/ISOO) Al-Dasooqi, N. Brennan, M. Gibson, R. Fulton, J. Hewson, I. Jensen, S.B. Logan, R. Öhrn, K.E.O. Sarri, T. Saunders, D. von Bültzingslöwen, I. Yarom, N. Allemano, J. Al-Azri, A.R. Antunes, H.S. Ariyawardana, A. Bateman, E. Blijlevens, N. Boers-Doets, C.B. Bossi, P. Brown, C.G. Chang, Y.-C. Cheng, K.K. Cooksley, C. Correa, E.P. Dennis, K. Di Palma, M. Drucker, S. Eilers, J. Escalante, C. Estilo, C.L. Everaus, H. Fijlstra, M. Fliedner, M. Freidank, A. Gerber, E. Gibson, F. Gomez, J.G. Halm, J. Hita, G. Hutchins, R.D. Hodgson, B. Hovan, A. Jarvis, V. King, E.E. Kouloulias, V.E. Latortue, M.C. Lees, J. Lopes, N.N.F. Loprinzi, C. Michelet, M. Mori, T. Nair, R.G. Niscola, P. Oberle-Edwards, L.K. Osaguona, A. Parelkar, P. Park, J. Parker, I. Pettersson, B.G. Potting, C. Rao, N.G. Riesenbeck, D. Rouleau, T. Schubert, M.M. Silverman, S., Jr. Soga, Y. Spijkervet, F.K.L. Stokman, M. Stringer, A.M. Tissing, W.J.E. van der Velden, W.J.F.M. van de Wetering, M.D. Vithala, M. Weikel, D.S. Yazbeck, R. Yeoh, E. Zadik, Y.

Abstract

BACKGROUND Mucositis is a highly significant, and sometimes dose-limiting, toxicity of cancer therapy. The goal of this systematic review was to update the Multinational Association of Supportive Care in Cancer and International Society of Oral Oncology (MASCC/ISOO) Clinical Practice Guidelines for mucositis. METHODS A literature search was conducted to identify eligible published articles, based on predefined inclusion/exclusion criteria. Each article was independently reviewed by 2 reviewers. Studies were rated according to the presence of major and minor flaws as per previously published criteria. The body of evidence for each intervention, in each treatment setting, was assigned a level of evidence, based on previously published criteria. Guidelines were developed based on the level of evidence, with 3 possible guideline determinations: recommendation, suggestion, or no guideline possible. RESULTS The literature search identified 8279 papers, 1032 of which were retrieved for detailed evaluation based on titles and abstracts. Of these, 570 qualified for final inclusion in the systematic reviews. Sixteen new guidelines were developed for or against the use of various interventions in specific treatment settings. In total, the MASCC/ISOO Mucositis Guidelines now include 32 guidelines: 22 for oral mucositis and 10 for gastrointestinal mucositis. This article describes these updated guidelines. CONCLUSIONS The updated MASCC/ISOO Clinical Practice Guidelines for mucositis will help clinicians provide evidence-based management of mucositis secondary to cancer therapy. © 2014 The Authors. Cancer published by Wiley Periodicals, Inc. on behalf of American Cancer Society.

Published
2014

12. Systematic review of amifostine for the management of oral mucositis in cancer patients

Author

Nicolatou-Galitis, O. Sarri, T. Bowen, J. Di Palma, M. Kouloulias, V.E. Niscola, P. Riesenbeck, D. Stokman, M. Tissing, W. Yeoh, E. Elad, S. Lalla, R.V.

Abstract

Purpose: The aim of this study was to review the available literature from 1966 until December 31, 2010 and define clinical practice guidelines for the use of amifostine for the prevention and treatment of oral mucositis in cancer patients. Methods: A systematic review was conducted by the Mucositis Study Group of the Multinational Association of Supportive Care in Cancer/International Society of Oral Oncology. The body of evidence for the use of amifostine, in each cancer treatment setting was assigned an evidence level. Based on the evidence level, one of the following three guideline determinations was possible: recommendation, suggestion, or no guideline possible. Results: Thirty papers were reviewed for evidence on amifostine as an intervention for oral mucositis. No guideline was possible for amifostine in any cancer treatment setting due to inadequate and conflicting evidence. Conclusion: Review of the amifostine studies for the prevention and treatment of oral mucositis has found insufficient evidence to support its use in any cancer treatment setting for this purpose. Additional well-designed research is needed to clarify the role of amifostine as an intervention for oral mucositis. © 2012 Springer-Verlag Berlin Heidelberg.

Published
2013

13. Systematic review of anti-inflammatory agents for the management of oral mucositis in cancer patients

Author

Nicolatou-Galitis, O. Sarri, T. Bowen, J. Di Palma, M. Kouloulias, V.E. Niscola, P. Riesenbeck, D. Stokman, M. Tissing, W. Yeoh, E. Elad, S. Lalla, R.V.

Abstract

Purpose: The aim of this project was to review the available literature and define clinical practice guidelines for the use of anti-inflammatory agents for the prevention and treatment of oral mucositis in cancer patients. Materials and methods: A systematic review was conducted by the Mucositis Study Group of the Multinational Association of Supportive Care in Cancer/International Society of Oral Oncology. The body of evidence for use of each intervention, in each cancer treatment setting, was assigned an evidence level. Based on the evidence level, one of the following three guideline determinations was possible: recommendation, suggestion, and no guideline possible. Results: Forty-one papers were reviewed. There was sufficient evidence to recommend the use of benzydamine mouthwash for the prevention of oral mucositis in head and neck cancer patients receiving moderate-dose radiation therapy (up to 50 Gy), without concomitant chemotherapy. A new suggestion was developed against the use of misoprostol mouthwash for the prevention of oral mucositis in head and neck cancer patients receiving radiation therapy. Positive results were reported for some other anti-inflammatory agents. However, no guidelines were able to be developed for any other agents due to insufficient and/or conflicting evidence. Conclusions: The use of anti-inflammatory agents continues to be a promising strategy for the prevention and treatment of oral mucositis. Additional well-designed studies are needed to examine the use of this class of agents for oral mucositis. © 2013 Springer-Verlag Berlin Heidelberg.

Published
2013

14. Complementary and alternative medicine experience in radiation oncology patients : first results of a multi-center approach

Author

Bruns, F, Glatzel, M, Schonekaes, K, Riesenbeck, D, Mucke, R, Buntzel, J, Micke, Patrick, Schafer, U, Kisters, K, Micke, O, Bruns, F, Glatzel, M, Schonekaes, K, Riesenbeck, D, Mucke, R, Buntzel, J, Micke, Patrick, Schafer, U, Kisters, K, and Micke, O

Abstract

In recent years the demand and use of complementary and alternative medicine (CAM) in malignant diseases has increased noticeably. Since the general knowledge about CAM use is scant and CAM could potentially interact with standard therapies the German Working group “Trace Elements and Electrolytes in Oncology” performed a multi-centric study to comprehensively evaluate the use of CAM therapies in cancer patients treated with radiotherapy. Methods: 1,013 patients receiving consecutively radiotherapy for malignant diseases were interviewed using a standardized questionnaire including clinical and pathological tumor parameters as well as the type of CAM and reasons for CAM use. A self-assessment of patients’ personal conditions was performed in order to evaluate the subjective impact of CAM on quality of life. Results: A total of 59% of patients reported using CAM therapies. CAM use was more common in female patients, generally higher in advanced stages of disease and most common in breast cancer patients. Most frequently reported CAM therapies were vitamins (18%), mistletoe extracts (15%), selenium (10%), and other trace element preparations (7%). Multivariate logistic regression showed age, gender, tumor type and stage, and smoking behavior to be significant predictors for CAM use. A subjective improvement in quality of life due to the use of CAM was accounted for in 30% of patients. Conclusions: More than half of patients undergoing RT for cancer are using CAM therapies. Therefore, radiation oncologists should be asking for respective obtaining information about CAM use in order to avoid harmful interactions with conventional therapies. The value and potential hazards of such combined treatments have yet to be tested in further clinical studies.

Published
2006
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15. Anticancer Res: limited effects of selenium substitution in the prevention of radiation-associated toxicities. Results of a randomized study in head and neck cancer patients

Author

Buntzel, J., Riesenbeck, D., and Glatzel, M.

Subjects
Care and treatment, Complications and side effects, Analysis, Patient outcomes, Selenium (Chemical element) -- Analysis, Radiotherapy -- Complications and side effects, Head and neck cancer -- Care and treatment -- Patient outcomes, Selenium -- Analysis
Abstract

OBJECTIVE: The substitution of selenium activates the selenium-dependent enzyme glutathione peroxidase, which is important for scavenging free radicals. To date, only limited data are available about the clinical impact of [...]

Published
2010

16. Preoperative chemoradiation (CRT) with concurrent capecitabine (Cap), oxaliplatin (Ox), and bevacizumab (Bev) in patients with locally advanced rectal cancer (RC): Effects on pathological complete response (pCR) and surgical complications.

Author

Hoehler, T., primary, Dellas, K., additional, Riesenbeck, D., additional, Reese, T., additional, Wuerschmidt, F., additional, Roedel, C., additional, Wagner, W., additional, Zuehlke, H., additional, Richter, M., additional, and Dunst, J., additional

Published
2011
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21. Orale Mukositis

Author

Doerr, W., primary, Groetz, K.A., additional, Hartmann, J.T., additional, and Riesenbeck, D., additional

Published
2007
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25. Neoadjuvant chemotherapy followed by preoperative radiochemotherapy (hfRTCT) plus surgery or surgery plus postoperative radiotherapy in stage III non-small cell lung cancer: Results of a randomized phase III trial of the German lung cancer cooperative group

Author

RUEBE, C, primary, RIESENBECK, D, additional, SEMIK, M, additional, MACHA, H, additional, WAHLERS, B, additional, SAUERLAND, C, additional, HEINECKE, H, additional, UKENA, D, additional, HOFFKNECHT, P, additional, and DROEGE, C, additional

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2004
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26. Cisplatin / etoposide (PE) followed by twice-daily chemoradiation (hfRT/CT) versus PE alone before surgery in stage III non-small cell lung cancer (NSCLC): A randomized phase III trial of the German Lung Cancer Cooperative Group (GLCCG)

Author

Thomas, M., primary, Macha, H. N., additional, Ukena, D., additional, Hamm, M., additional, Deppermann, M., additional, Semik, M., additional, Riesenbeck, D., additional, Rübe, C., additional, and Heinecke, A., additional

Published
2004
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27. DEGRO 2004

Author

Wendt, Thomas G., primary, Gademann, G., additional, Pambor, C., additional, Grießbach, I., additional, von Specht, H., additional, Martin, T., additional, Baltas, D., additional, Kurek, R., additional, Röddiger, S., additional, Tunn, U. W., additional, Zamboglou, N., additional, Eich, H. T., additional, Staar, S., additional, Gossmann, A., additional, Hansemann, K., additional, Semrau, R., additional, Skripnitchenko, R., additional, Diehl, V., additional, Müller, R.-P., additional, Sehlen, S., additional, Willich, N., additional, Rühl, U., additional, Lukas, P., additional, Dühmke, E., additional, Engel, K., additional, Tabbert, E., additional, Bolck, M., additional, Knaack, S., additional, Annweiler, H., additional, Krempien, R., additional, Hoppe, H., additional, Harms, W., additional, Daeuber, S., additional, Schorr, O., additional, Treiber, M., additional, Debus, J., additional, Alber, M., additional, Paulsen, F., additional, Birkner, M., additional, Bakai, A., additional, Belka, C., additional, Budach, W., additional, Grosser, K.-H., additional, Kramer, R., additional, Kober, B., additional, Reinert, M., additional, Schneider, P., additional, Hertel, A., additional, Feldmann, H., additional, Csere, P., additional, Hoinkis, C., additional, Rothe, G., additional, Zahn, P., additional, Alheit, H., additional, Cavanaugh, S. X., additional, Kupelian, P., additional, Reddy, C., additional, Pollock, B., additional, Fuss, M., additional, Roeddiger, S., additional, Dannenberg, T., additional, Rogge, B., additional, Drechsler, D., additional, Herrmann, T., additional, Alberti, W., additional, Schwarz, R., additional, Graefen, M., additional, Krüll, A., additional, Rudat, V., additional, Huland, H., additional, Fehr, C., additional, Baum, C., additional, Glocker, S., additional, Nüsslin, F., additional, Heil, T., additional, Lemnitzer, H., additional, Knips, M., additional, Baumgart, O., additional, Thiem, W., additional, Kloetzer, K.-H., additional, Hoffmann, L., additional, Neu, B., additional, Hültenschmidt, B., additional, Sautter-Bihl, M.-L., additional, Micke, O., additional, Seegenschmiedt, M. H., additional, Köppen, D., additional, Klautke, G., additional, Fietkau, R., additional, Schultze, J., additional, Schlichting, G., additional, Koltze, H., additional, Kimmig, B., additional, Glatzel, M., additional, Fröhlich, D., additional, Bäsecke, S., additional, Krauß, A., additional, Strauß, D., additional, Buth, K.-J., additional, Böhme, R., additional, Oehler, W., additional, Bottke, D., additional, Keilholz, U., additional, Heufelder, K., additional, Wiegel, T., additional, Hinkelbein, W., additional, Rödel, C., additional, Papadopoulos, T., additional, Munnes, M., additional, Wirtz, R., additional, Sauer, R., additional, Rödel, F., additional, Lubgan, D., additional, Distel, L., additional, Grabenbauer, G. G., additional, Sak, A., additional, Stüben, G., additional, Pöttgen, C., additional, Grehl, S., additional, Stuschke, M., additional, Müller, K., additional, Pfaffendorf, C., additional, Mayerhofer, A., additional, Köhn, F. M., additional, Ring, J., additional, van Beuningen, D., additional, Meineke, V., additional, Neubauer, S., additional, Keller, U., additional, Wittlinger, M., additional, Riesenbeck, D., additional, Greve, B., additional, Exeler, R., additional, Ibrahim, M., additional, Liebscher, C., additional, Severin, E., additional, Ott, O., additional, Pötter, R., additional, Hammer, J., additional, Hildebrandt, G., additional, Beckmann, M. W., additional, Strnad, V., additional, Fehlauer, F., additional, Tribius, S., additional, Bajrovic, A., additional, Höller, U., additional, Rades, D., additional, Warszawski, A., additional, Baumann, R., additional, Madry-Gevecke, B., additional, Karstens, J. H., additional, Grehn, C., additional, Hensley, F., additional, Berns, C., additional, Wannenmacher, M., additional, Semrau, S., additional, Reimer, T., additional, Gerber, B., additional, Ketterer, P., additional, Koepcke, E., additional, Hänsgen, G., additional, Strauß, H. G., additional, Dunst, J., additional, Füller, J., additional, Kalb, S., additional, Wendt, T., additional, Weitmann, H. D., additional, Waldhäusl, C., additional, Knocke, T.-H., additional, Lamprecht, U., additional, Classen, J., additional, Kaulich, T. W., additional, Aydeniz, B., additional, Bamberg, M., additional, Wiezorek, T., additional, Banz, N., additional, Salz, H., additional, Scheithauer, M., additional, Schwedas, M., additional, Lutterbach, J., additional, Bartelt, S., additional, Frommhold, H., additional, Lambert, J., additional, Hornung, D., additional, Swiderski, S., additional, Walke, M., additional, Siefert, A., additional, Pöllinger, B., additional, Krimmel, K., additional, Schaffer, M., additional, Koelbl, O., additional, Bratengeier, K., additional, Vordermark, D., additional, Flentje, M., additional, Hero, B., additional, Berthold, F., additional, Combs, S. E., additional, Gutwein, S., additional, Schulz-Ertner, D., additional, van Kampen, M., additional, Thilmann, C., additional, Kocher, M., additional, Kunze, S., additional, Schild, S., additional, Ikezaki, K., additional, Müller, B., additional, Sieber, R., additional, Weiß, C., additional, Wolf, I., additional, Wenz, F., additional, Weber, K.-J., additional, Schäfer, J., additional, Engling, A., additional, Laufs, S., additional, Veldwijk, M. R., additional, Milanovic, D., additional, Fleckenstein, K., additional, Zeller, W., additional, Fruehauf, S., additional, Herskind, C., additional, Weinmann, M., additional, Jendrossek, V., additional, Rübe, C., additional, Appold, S., additional, Kusche, S., additional, Hölscher, T., additional, Brüchner, K., additional, Geyer, P., additional, Baumann, M., additional, Kumpf, R., additional, Zimmermann, F., additional, Schill, S., additional, Geinitz, H., additional, Nieder, C., additional, Jeremic, B., additional, Molls, M., additional, Liesenfeld, S., additional, Petrat, H., additional, Hesselmann, S., additional, Schäfer, U., additional, Bruns, F., additional, Horst, E., additional, Wilkowski, R., additional, Assmann, G., additional, Nolte, A., additional, Diebold, J., additional, Löhrs, U., additional, Fritz, P., additional, Hans-Jürgen, K., additional, Mühlnickel, W., additional, Bach, P., additional, Wahlers, B., additional, Kraus, H.-J., additional, Wulf, J., additional, Hädinger, U., additional, Baier, K., additional, Krieger, T., additional, Müller, G., additional, Hof, H., additional, Herfarth, K., additional, Brunner, T., additional, Hahn, S. M., additional, Schreiber, F. S., additional, Rustgi, A. K., additional, McKenna, W. G., additional, Bernhard, E. J., additional, Guckenberger, M., additional, Meyer, K., additional, Willner, J., additional, Schmidt, M., additional, Kolb, M., additional, Li, M., additional, Gong, P., additional, Abdollahi, A., additional, Trinh, T., additional, Huber, P. E., additional, Christiansen, H., additional, Saile, B., additional, Neubauer-Saile, K., additional, Tippelt, S., additional, Rave-Fränk, M., additional, Hermann, R. M., additional, Dudas, J., additional, Hess, C. F., additional, Schmidberger, H., additional, Ramadori, G., additional, Andratschke, N., additional, Price, R., additional, Ang, K.-K., additional, Schwarz, S., additional, Kulka, U., additional, Busch, M., additional, Schlenger, L., additional, Bohsung, J., additional, Eichwurzel, I., additional, Matnjani, G., additional, Sandrock, D., additional, Richter, M., additional, Wurm, R., additional, Budach, V., additional, Feussner, A., additional, Gellermann, J., additional, Jordan, A., additional, Scholz, R., additional, Gneveckow, U., additional, Maier-Hauff, K., additional, Ullrich, R., additional, Wust, P., additional, Felix, R., additional, Waldöfner, N., additional, Seebass, M., additional, Ochel, H.-J., additional, Dani, A., additional, Varkonyi, A., additional, Osvath, M., additional, Szasz, A., additional, Messer, P. M., additional, Blumstein, N. M., additional, Gottfried, H.-W., additional, Schneider, E., additional, Reske, S. N., additional, Röttinger, E. M., additional, Grosu, A.-L., additional, Franz, M., additional, Stärk, S., additional, Weber, W., additional, Heintz, M., additional, Indenkämpen, F., additional, Beyer, T., additional, Lübcke, W., additional, Levegrün, S., additional, Hayen, J., additional, Czech, N., additional, Mbarek, B., additional, Köster, R., additional, Thurmann, H., additional, Todorovic, M., additional, Schuchert, A., additional, Meinertz, T., additional, Münzel, T., additional, Grundtke, H., additional, Hornig, B., additional, Hehr, T., additional, Dilcher, C., additional, Chan, R. C., additional, Mintz, G. S., additional, Kotani, J.-I., additional, Shah, V. M., additional, Canos, D. A., additional, Weissman, N. J., additional, Waksman, R., additional, Wolfram, R., additional, Bürger, B., additional, Schrappe, M., additional, Timmermann, B., additional, Lomax, A., additional, Goitein, G., additional, Schuck, A., additional, Mattke, A., additional, Int-Veen, C., additional, Brecht, I., additional, Bernhard, S., additional, Treuner, J., additional, Koscielniak, E., additional, Heinze, F., additional, Kuhlen, M., additional, von Schorlemer, I., additional, Ahrens, S., additional, Hunold, A., additional, Könemann, S., additional, Winkelmann, W., additional, Jürgens, H., additional, Gerstein, J., additional, Polivka, B., additional, Sykora, K.-W., additional, Bremer, M., additional, Thamm, R., additional, Höpfner, C., additional, Gumprecht, H., additional, Jäger, R., additional, Leonardi, M. A., additional, Frank, A. M., additional, Trappe, A. E., additional, Lumenta, C. B., additional, Östreicher, E., additional, Pinsker, K., additional, Müller, A., additional, Fauser, C., additional, Arnold, W., additional, Henzel, M., additional, Groß, M. W., additional, Engenhart-Cabillic, R., additional, Schüller, P., additional, Palkovic, S., additional, Schröder, J., additional, Wassmann, H., additional, Block, A., additional, Bauer, R., additional, Keffel, F.-W., additional, Theophil, B., additional, Wisser, L., additional, Rogger, M., additional, Niewald, M., additional, van Lengen, V., additional, Mathias, K., additional, Welzel, G., additional, Bohrer, M., additional, Steinvorth, S., additional, Schleußner, C., additional, Leppert, K., additional, Röhrig, B., additional, Strauß, B., additional, van Oorschot, B., additional, Köhler, N., additional, Anselm, R., additional, Winzer, A., additional, Schneider, T., additional, Koch, U., additional, Schönekaes, K., additional, Mücke, R., additional, Büntzel, J., additional, Kisters, K., additional, Scholz, C., additional, Keller, M., additional, Winkler, C., additional, Prause, N., additional, Busch, R., additional, Roth, S., additional, Haas, I., additional, Willers, R., additional, Schultze-Mosgau, S., additional, Wiltfang, J., additional, Kessler, P., additional, Neukam, F. W., additional, Röper, B., additional, Nüse, N., additional, Auer, F., additional, Melzner, W., additional, Geiger, M., additional, Lotter, M., additional, Kuhnt, T., additional, Müller, A. C., additional, Jirsak, N., additional, Gernhardt, C., additional, Schaller, H.-G., additional, Al-Nawas, B., additional, Klein, M. O., additional, Ludwig, C., additional, Körholz, J., additional, Grötz, K. A., additional, Huppers, K., additional, Kunkel, M., additional, Olschewski, T., additional, Bajor, K., additional, Lang, B., additional, Lang, E., additional, Kraus-Tiefenbacher, U., additional, Hofheinz, R., additional, von Gerstenberg-Helldorf, B., additional, Willeke, F., additional, Hochhaus, A., additional, Roebel, M., additional, Oertel, S., additional, Riedl, S., additional, Buechler, M., additional, Foitzik, T., additional, Ludwig, K., additional, Klar, E., additional, Meyer, A., additional, Meier zu Eissen, J., additional, Schwab, D., additional, Meyer, T., additional, Höcht, S., additional, Siegmann, A., additional, Sieker, F., additional, Pigorsch, S., additional, Milicic, B., additional, Acimovic, L., additional, Milisavljevic, S., additional, Radosavljevic-Asic, G., additional, Presselt, N., additional, Baum, R. P., additional, Treutler, D., additional, Bonnet, R., additional, Schmücking, M., additional, Sammour, D., additional, Fink, T., additional, Ficker, J., additional, Pradier, O., additional, Lederer, K., additional, Weiss, E., additional, Hille, A., additional, Welz, S., additional, Sepe, S., additional, Friedel, G., additional, Spengler, W., additional, Susanne, E., additional, Kölbl, O., additional, Hoffmann, W., additional, Wörmann, B., additional, Günther, A., additional, Becker-Schiebe, M., additional, Güttler, J., additional, Schul, C., additional, Nitsche, M., additional, Körner, M. K., additional, Oppenkowski, R., additional, Guntrum, F., additional, Malaimare, L., additional, Raub, M., additional, Schöfl, C., additional, Averbeck, T., additional, Hacker, I., additional, Blank, H., additional, Böhme, C., additional, Imhoff, D., additional, Eberlein, K., additional, Weidauer, S., additional, Böttcher, H. D., additional, Edler, L., additional, Tatagiba, M., additional, Molina, H., additional, Ostertag, C., additional, Milker-Zabel, S., additional, Zabel, A., additional, Schlegel, W., additional, Hartmann, A., additional, Wildfang, I., additional, Kleinert, G., additional, Hamm, K., additional, Reuschel, W., additional, Wehrmann, R., additional, Kneschaurek, P., additional, Münter, M. W., additional, Nikoghosyan, A., additional, Didinger, B., additional, Nill, S., additional, Rhein, B., additional, Küstner, D., additional, Schalldach, U., additional, Eßer, D., additional, Göbel, H., additional, Wördehoff, H., additional, Pachmann, S., additional, Hollenhorst, H., additional, Dederer, K., additional, Evers, C., additional, Lamprecht, J., additional, Dastbaz, A., additional, Schick, B., additional, Fleckenstein, J., additional, Plinkert, P. K., additional, Rübe, Chr., additional, Merz, T., additional, Sommer, B., additional, Mencl, A., additional, Ghilescu, V., additional, Astner, S., additional, Martin, A., additional, Momm, F., additional, Volegova-Neher, N. J., additional, Schulte-Mönting, J., additional, Guttenberger, R., additional, Buchali, A., additional, Blank, E., additional, Sidow, D., additional, Huhnt, W., additional, Gorbatov, T., additional, Heinecke, A., additional, Beckmann, G., additional, Bentia, A.-M., additional, Schmitz, H., additional, Spahn, U., additional, Heyl, V., additional, Prott, P.-J., additional, Galalae, R., additional, Schneider, R., additional, Voith, C., additional, Scheda, A., additional, Hermann, B., additional, Bauer, L., additional, Melchert, F., additional, Kröger, N., additional, Grüneisen, A., additional, Jänicke, F., additional, Zander, A., additional, Zuna, I., additional, Schlöcker, I., additional, Wagner, K., additional, John, E., additional, Dörk, T., additional, Lochhas, G., additional, Houf, M., additional, Lorenz, D., additional, Link, K.-H., additional, Prott, F.-J., additional, Thoma, M., additional, Schauer, R., additional, Heinemann, V., additional, Romano, M., additional, Reiner, M., additional, Quanz, A., additional, Oppitz, U., additional, Bahrehmand, R., additional, Tine, M., additional, Naszaly, A., additional, Patonay, P., additional, Mayer, Á., additional, Markert, K., additional, Mai, S.-K., additional, Lohr, F., additional, Dobler, B., additional, Pinkawa, M., additional, Fischedick, K., additional, Treusacher, P., additional, Cengiz, D., additional, Mager, R., additional, Borchers, H., additional, Jakse, G., additional, Eble, M. J., additional, Asadpour, B., additional, Krenkel, B., additional, Holy, R., additional, Kaplan, Y., additional, Block, T., additional, Czempiel, H., additional, Haverkamp, U., additional, Prümer, B., additional, Christian, T., additional, Benkel, P., additional, Weber, C., additional, Gruber, S., additional, Reimann, P., additional, Blumberg, J., additional, Krause, K., additional, Fischedick, A.-R., additional, Kaube, K., additional, Steckler, K., additional, Henzel, B., additional, Licht, N., additional, Loch, T., additional, Krystek, A., additional, Lilienthal, A., additional, Alfia, H., additional, Claßen, J., additional, Spillner, P., additional, Knutzen, B., additional, Souchon, R., additional, Schulz, I., additional, Grüschow, K., additional, Küchenmeister, U., additional, Vogel, H., additional, Wolff, D., additional, Ramm, U., additional, Licner, J., additional, Rudolf, F., additional, Moog, J., additional, Rahl, C. G., additional, Mose, S., additional, Vorwerk, H., additional, Weiß, E., additional, Engert, A., additional, Seufert, I., additional, Schwab, F., additional, Dahlke, J., additional, Zabelina, T., additional, Krüger, W., additional, Kabisch, H., additional, Platz, V., additional, Wolf, J., additional, Pfistner, B., additional, Stieltjes, B., additional, Wilhelm, T., additional, Schmuecking, M., additional, Junker, K., additional, Treutier, D., additional, Schneider, C. P., additional, Leonhardi, J., additional, Niesen, A., additional, Hoeffken, K., additional, Schmidt, A., additional, Mueller, K.-M., additional, Schmid, I., additional, Lehmann, K., additional, Blumstein, C. G., additional, Kreienberg, R., additional, Freudenberg, L., additional, Kühl, H., additional, Stahl, M., additional, Elo, B., additional, Erichsen, P., additional, Stattaus, H., additional, Welzel, T., additional, Mende, U., additional, Heiland, S., additional, Salter, B. J., additional, Schmid, R., additional, Stratakis, D., additional, Huber, R. M., additional, Haferanke, J., additional, Zöller, N., additional, Henke, M., additional, Lorenzen, J., additional, Grzyska, B., additional, Kuhlmey, A., additional, Adam, G., additional, Hamelmann, V., additional, Bölling, T., additional, Job, H., additional, Panke, J. E., additional, Feyer, P., additional, Püttmann, S., additional, Siekmeyer, B., additional, Jung, H., additional, Gagel, B., additional, Militz, U., additional, Piroth, M., additional, Schmachtenberg, A., additional, Hoelscher, T., additional, Verfaillie, C., additional, Kaminski, B., additional, Lücke, E., additional, Mörtel, H., additional, Eyrich, W., additional, Fritsch, M., additional, Georgi, J.-C., additional, Plathow, C., additional, Zieher, H., additional, Kiessling, F., additional, Peschke, P., additional, Kauczor, H.-U., additional, Licher, J., additional, Schneider, O., additional, Henschler, R., additional, Seidel, C., additional, Kolkmeyer, A., additional, Nguyen, T. P., additional, Janke, K., additional, Michaelis, M., additional, Bischof, M., additional, Stoffregen, C., additional, Lipson, K., additional, Weber, K., additional, Ehemann, V., additional, Jürgen, D., additional, Achanta, P., additional, Thompson, K., additional, Martinez, J. L., additional, Körschgen, T., additional, Pakala, R., additional, Pinnow, E., additional, Hellinga, D., additional, O’Tio, F., additional, Katzer, A., additional, Kaffer, A., additional, Kuechler, A., additional, Steinkirchner, S., additional, Dettmar, N., additional, Cordes, N., additional, Frick, S., additional, Kappler, M., additional, Taubert, H., additional, Bartel, F., additional, Schmidt, H., additional, Bache, M., additional, Frühauf, S., additional, Wenk, T., additional, Litzenberger, K., additional, Erren, M., additional, van Valen, F., additional, Liu, L., additional, Yang, K., additional, Palm, J., additional, Püsken, M., additional, Behe, M., additional, Behr, T. M., additional, Marini, P., additional, Johne, A., additional, Claussen, U., additional, Liehr, T., additional, Steil, V., additional, Moustakis, C., additional, Griessbach, I., additional, Oettel, A., additional, Schaal, C., additional, Reinhold, M., additional, Strasssmann, G., additional, Braun, I., additional, Vacha, P., additional, Richter, D., additional, Osterham, T., additional, Wolf, P., additional, Guenther, G., additional, Miemietz, M., additional, Lazaridis, E. A., additional, Forthuber, B., additional, Sure, M., additional, Klein, J., additional, Saleske, H., additional, Riedel, T., additional, Hirnle, P., additional, Horstmann, G., additional, Schoepgens, H., additional, Van Eck, A., additional, Bundschuh, O., additional, Van Oosterhut, A., additional, Xydis, K., additional, Theodorou, K., additional, Kappas, C., additional, Zurheide, J., additional, Fridtjof, N., additional, Ganswindt, U., additional, Weidner, N., additional, Buchgeister, M., additional, Weigel, B., additional, Müller, S. B., additional, Glashörster, M., additional, Weining, C., additional, Hentschel, B., additional, Sauer, O. A., additional, Kleen, W., additional, Beck, J., additional, Lehmann, D., additional, Ley, S., additional, Fink, C., additional, Puderbach, M., additional, Hosch, W., additional, Schmähl, A., additional, Jung, K., additional, Stoßberg, A., additional, Rolf, E., additional, Damrau, M., additional, Oetzel, D., additional, Maurer, U., additional, Maurer, G., additional, Lang, K., additional, Zumbe, J., additional, Hahm, D., additional, Fees, H., additional, Robrandt, B., additional, Melcher, U., additional, Niemeyer, M., additional, Mondry, A., additional, Kanellopoulos-Niemeyer, V., additional, Karle, H., additional, Jacob-Heutmann, D., additional, Born, C., additional, Mohr, W., additional, Kutzner, J., additional, Thelen, M., additional, Schiebe, M., additional, Pinkert, U., additional, Piasswilm, L., additional, Pohl, F., additional, Garbe, S., additional, Wolf, K., additional, Nour, Y., additional, Barwig, P., additional, Trog, D., additional, Schäfer, C., additional, Herbst, M., additional, Dietl, B., additional, Cartes, M., additional, Schroeder, F., additional, Sigingan-Tek, G., additional, Feierabend, R., additional, Theden, S., additional, Schlieck, A., additional, Gotthardt, M., additional, Glowalla, U., additional, Kremp, S., additional, Hamid, O., additional, Riefenstahl, N., additional, Michaelis, B., additional, Schaal, G., additional, Liebermeister, E., additional, Niewöhner-Desbordes, U., additional, Kowalski, M., additional, Franz, N., additional, Stahl, W., additional, Baumbach, C., additional, Thale, J., additional, Wagner, W., additional, Justus, B., additional, Huston, A. L., additional, Seaborn, R., additional, Rai, P., additional, Rha, S.-W., additional, Sakas, G., additional, Wesarg, S., additional, Zogal, P., additional, Schwald, B., additional, Seibert, H., additional, Berndt-Skorka, R., additional, Seifert, G., additional, Schoenekaes, K., additional, Bilecen, C., additional, Ito, W., additional, Matschuck, G., additional, and Isik, D., additional

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2004
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29. Time‐ and dose‐dependent changes of intracellular cytokine and cytokine receptor profile of Ewing tumour subpopulations under the influence of ionizing radiation

Author

Könemann, S., primary, Bölling, T., additional, Malath, J., additional, Kolkmeyer, A., additional, Janke, K., additional, Riesenbeck, D., additional, Hesselmann, S., additional, Diallo, R., additional, Vormoor, J., additional, Willich, N., additional, and Schuck, A., additional

Published
2003
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37. A systematic review of trismus induced by cancer therapies in head and neck cancer patients.

Author

Bensadoun RJ, Riesenbeck D, Lockhart PB, Elting LS, Spijkervet FK, Brennan MT, Trismus Section, Oral Care Study Group, Multinational Association for Supportive Care in Cancer (MASCC)/International Society of Oral Oncology (ISOO), Bensadoun, Rene-Jean, Riesenbeck, Dorothea, Lockhart, Peter B, Elting, Linda S, Spijkervet, Fred K L, and Brennan, Mike T

Abstract

Purpose: This systematic review represents a thorough evaluation of the literature to clarify the impact of cancer therapies on the prevalence, quality of life and economic impact, and management strategies for cancer-therapy-induced trismus.Methods: A systematic literature search was conducted with assistance from a research librarian in the databases MEDLINE/PubMed and EMBASE for articles published between January 1, 1990 and December 31, 2008. Each study was independently assessed by two reviewers. Taking into account predetermined quality measures, a weighted prevalence was calculated for the prevalence of trismus. The level of evidence, recommendation grade, and guideline (if possible) were given for published preventive and management strategies for trismus.Results: We reviewed a total of 22 published studies between 1990 and 2008. Most of them assessed the prevalence of this complication, and few focused on management. The weighted prevalence for trismus was 25.4% in patients who received conventional radiotherapy and 5% for the few intensity-modulated radiation therapy studies. No clear guideline recommendations could be made for the prevention or management of trismus.Conclusions: Newer radiation modalities may decrease the prevalence of trismus compared to conventional radiotherapy. Few studies have addressed the quality of life impact of trismus, and no studies were identified to assess the economic impact of trismus. The few preventive and management trials identified in the literature showed some promise, although larger, well-designed studies are required to appropriately assess these therapies before recommendations can be provided. [ABSTRACT FROM AUTHOR]

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2010
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40. Effect of preoperative chemoradiation in addition to preoperative chemotherapy: a randomised trial in stage III non-small-cell lung cancer.

Author

Thomas M, Rübe C, Hoffknecht P, Macha HN, Freitag L, Linder A, Willich N, Hamm M, Sybrecht GW, Ukena D, Deppermann KM, Dröge C, Riesenbeck D, Heinecke A, Sauerland C, Junker K, Berdel WE, Semik M, and German Lung Cancer Cooperative Group

Abstract

BACKGROUND: Preoperative chemotherapy improves survival in patients with stage III non-small-cell lung cancer (NSCLC) amenable to resection. We aimed to assess the additional effect of preoperative chemoradiation on tumour resection, pathological response, and survival in these patients. METHODS: Between Oct 1, 1995, and July 1, 2003, patients with stage IIIA-IIIB NSCLC and invasive mediastinal assessment from 26 participating institutions of the German Lung Cancer Cooperative Group (GLCCG) were randomly assigned to one of two treatment groups. The intervention group were scheduled to receive three cycles of cisplatin and etoposide, followed by twice-daily radiation with concurrent carboplatin and vindesine, and then surgical resection (those with positive resection margins or unresectable disease were offered further twice-daily radiotherapy). The control group were scheduled to receive three cycles of cisplatin and etoposide, followed by surgery, and then further radiotherapy. The primary endpoint was median progression-free survival (PFS) in patients eligible for treatment after randomisation. Secondary endpoints in patients eligible for treatment after randomisation were overall survival (OS) and the proportion of patients undergoing surgery. Secondary endpoints in patients with tumour resection were the proportion with negative resection margins, the proportion with complete resection, the proportion with histopathological response, and the proportion with mediastinal downstaging. Additionally, exploratory (not prespecified) post-hoc analyses in terms of PFS and OS were done on patients not amenable to resection and on further subgroups of patients undergoing resection. Analyses were by intention to treat. This trial is registered on the ClinicalTrials.gov website, number NCT 00176137. FINDINGS: 558 patients were randomly assigned. 34 patients did not meet inclusion criteria and were excluded. Of 524 eligible patients, 142 of 264 (54%) in the interventional group and 154 of 260 (59%) in the control group underwent surgery; 98 of 264 (37%) and 84 of 260 (32%) underwent complete resection. In patients with complete resection, the proportion of those with mediastinal downstaging (45 of 98 [46%] and 24 of 84 [29%], p=0.02) and pathological response (59 of 98 [60%] and 17 of 84 [20%], p<0.0001) favoured the interventional group. However, there was no difference in PFS (primary endpoint) between treatment groups-either in eligible patients (median PFS 9.5 months, range 1.0-117.0 [95% CI 8.3-11.2] vs 10.0 months, range 1.0-111.0 [8.9-11.5], 5-year PFS 16% [11-21] vs 14% [10-19], hazard ratio (HR) 0.99 [0.81-1.19], p=0.87), in those undergoing tumour resection, or in patients with complete resection. In both groups, 35% of patients undergoing surgery received a pneumonectomy (50/142 vs 54/154). In patients receiving a pneumonectomy, treatment-related mortality increased in the interventional group compared with the control group (7/50 [14%] vs 3/54 [6%]). INTERPRETATION: In patients with stage III NSCLC amenable to surgery, preoperative chemoradiation in addition to chemotherapy increases pathological response and mediastinal downstaging, but does not improve survival. After induction with chemoradiation, pneumonectomy should be avoided. FUNDING: German Cancer Aid (Bonn, Germany). [ABSTRACT FROM AUTHOR]

Published
2008
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43. Fertility Preservation for Patients with Malignant Disease. Guideline of the DGGG, DGU and DGRM (S2k-Level, AWMF Registry No. 015/082, November 2017) - Recommendations and Statements for Girls and Women.

Author

Dittrich R, Kliesch S, Schüring A, Balcerek M, Baston-Büst DM, Beck R, Beckmann MW, Behringer K, Borgmann-Staudt A, Cremer W, Denzer C, Diemer T, Dorn A, Fehm T, Gaase R, Germeyer A, Geue K, Ghadjar P, Goeckenjan M, Götte M, Guth D, Hauffa BP, Hehr U, Hetzer F, Hirchenhain J, Hoffmann W, Hornemann B, Jantke A, Kentenich H, Kiesel L, Köhn FM, Korell M, Lax S, Liebenthron J, Lux M, Meißner J, Micke O, Nassar N, Nawroth F, Nordhoff V, Ochsendorf F, Oppelt PG, Pelz J, Rau B, Reisch N, Riesenbeck D, Schlatt S, Sender A, Schwab R, Siedentopf F, Thorn P, Wagner S, Wildt L, Wimberger P, Wischmann T, von Wolff M, and Lotz L

Abstract

Aim: The aim of this official guideline published by the German Society of Gynecology and Obstetrics (DGGG) and coordinated with the German Society of Urology (DGU) and the German Society of Reproductive Medicine (DGRM) is to provide consensus-based recommendations, obtained by evaluating the relevant literature, on counseling and fertility preservation for prepubertal girls and boys as well as patients of reproductive age. Statements and recommendations for girls and women are presented below. Statements or recommendations for boys and men are not the focus of this guideline., Methods: This S2k guideline was developed at the suggestion of the guideline commission of the DGGG, DGU and DGRM and represents the structured consensus of representative members from various professional associations (n = 40)., Recommendations: The guideline provides recommendations on counseling and fertility preservation for women and girls which take account of the patient's personal circumstances, the planned oncologic therapy and the individual risk profile as well as the preferred approach for selected tumor entities.

Published
2018
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44. Systematic review of anti-inflammatory agents for the management of oral mucositis in cancer patients.

Author

Nicolatou-Galitis O, Sarri T, Bowen J, Di Palma M, Kouloulias VE, Niscola P, Riesenbeck D, Stokman M, Tissing W, Yeoh E, Elad S, and Lalla RV

Subjects
Chemoradiotherapy adverse effects, Head and Neck Neoplasms therapy, Humans, Mouthwashes therapeutic use, Practice Guidelines as Topic, Stomatitis prevention & control, Anti-Inflammatory Agents therapeutic use, Head and Neck Neoplasms complications, Stomatitis drug therapy
Abstract

Purpose: The aim of this project was to review the available literature and define clinical practice guidelines for the use of anti-inflammatory agents for the prevention and treatment of oral mucositis in cancer patients., Materials and Methods: A systematic review was conducted by the Mucositis Study Group of the Multinational Association of Supportive Care in Cancer/International Society of Oral Oncology. The body of evidence for use of each intervention, in each cancer treatment setting, was assigned an evidence level. Based on the evidence level, one of the following three guideline determinations was possible: recommendation, suggestion, and no guideline possible., Results: Forty-one papers were reviewed. There was sufficient evidence to recommend the use of benzydamine mouthwash for the prevention of oral mucositis in head and neck cancer patients receiving moderate-dose radiation therapy (up to 50 Gy), without concomitant chemotherapy. A new suggestion was developed against the use of misoprostol mouthwash for the prevention of oral mucositis in head and neck cancer patients receiving radiation therapy. Positive results were reported for some other anti-inflammatory agents. However, no guidelines were able to be developed for any other agents due to insufficient and/or conflicting evidence., Conclusions: The use of anti-inflammatory agents continues to be a promising strategy for the prevention and treatment of oral mucositis. Additional well-designed studies are needed to examine the use of this class of agents for oral mucositis.

Published
2013
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45. Systematic review of amifostine for the management of oral mucositis in cancer patients.

Author

Nicolatou-Galitis O, Sarri T, Bowen J, Di Palma M, Kouloulias VE, Niscola P, Riesenbeck D, Stokman M, Tissing W, Yeoh E, Elad S, and Lalla RV

Subjects
Administration, Topical, Amifostine administration & dosage, Amifostine adverse effects, Evidence-Based Medicine, Humans, Infusions, Intravenous, Injections, Subcutaneous, Neoplasms drug therapy, Neoplasms radiotherapy, Practice Guidelines as Topic, Radiation-Protective Agents administration & dosage, Radiation-Protective Agents adverse effects, Stomatitis etiology, Stomatitis prevention & control, Amifostine therapeutic use, Neoplasms complications, Radiation-Protective Agents therapeutic use, Stomatitis therapy
Abstract

Purpose: The aim of this study was to review the available literature from 1966 until December 31, 2010 and define clinical practice guidelines for the use of amifostine for the prevention and treatment of oral mucositis in cancer patients., Methods: A systematic review was conducted by the Mucositis Study Group of the Multinational Association of Supportive Care in Cancer/International Society of Oral Oncology. The body of evidence for the use of amifostine, in each cancer treatment setting was assigned an evidence level. Based on the evidence level, one of the following three guideline determinations was possible: recommendation, suggestion, or no guideline possible., Results: Thirty papers were reviewed for evidence on amifostine as an intervention for oral mucositis. No guideline was possible for amifostine in any cancer treatment setting due to inadequate and conflicting evidence., Conclusion: Review of the amifostine studies for the prevention and treatment of oral mucositis has found insufficient evidence to support its use in any cancer treatment setting for this purpose. Additional well-designed research is needed to clarify the role of amifostine as an intervention for oral mucositis.

Published
2013
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46. Evaluation of different biomarkers to predict individual radiosensitivity in an inter-laboratory comparison--lessons for future studies.

Author

Greve B, Bölling T, Amler S, Rössler U, Gomolka M, Mayer C, Popanda O, Dreffke K, Rickinger A, Fritz E, Eckardt-Schupp F, Sauerland C, Braselmann H, Sauter W, Illig T, Riesenbeck D, Könemann S, Willich N, Mörtl S, Eich HT, and Schmezer P

Subjects
Cells, Cultured, Comet Assay, DNA Damage physiology, Dose-Response Relationship, Radiation, Histones metabolism, Humans, Lymphocytes metabolism, Lymphocytes radiation effects, Radiation, Ionizing, Biomarkers analysis, Radiation Tolerance physiology
Abstract

Radiotherapy is a powerful cure for several types of solid tumours, but its application is often limited because of severe side effects in individual patients. With the aim to find biomarkers capable of predicting normal tissue side reactions we analysed the radiation responses of cells from individual head and neck tumour and breast cancer patients of different clinical radiosensitivity in a multicentric study. Multiple parameters of cellular radiosensitivity were analysed in coded samples of peripheral blood lymphocytes (PBLs) and derived lymphoblastoid cell lines (LCLs) from 15 clinical radio-hypersensitive tumour patients and compared to age- and sex-matched non-radiosensitive patient controls and 15 lymphoblastoid cell lines from age- and sex- matched healthy controls of the KORA study. Experimental parameters included ionizing radiation (IR)-induced cell death (AnnexinV), induction and repair of DNA strand breaks (Comet assay), induction of yH2AX foci (as a result of DNA double strand breaks), and whole genome expression analyses. Considerable inter-individual differences in IR-induced DNA strand breaks and their repair and/or cell death could be detected in primary and immortalised cells with the applied assays. The group of clinically radiosensitive patients was not unequivocally distinguishable from normal responding patients nor were individual overreacting patients in the test system unambiguously identified by two different laboratories. Thus, the in vitro test systems investigated here seem not to be appropriate for a general prediction of clinical reactions during or after radiotherapy due to the experimental variability compared to the small effect of radiation sensitivity. Genome-wide expression analysis however revealed a set of 67 marker genes which were differentially induced 6 h after in vitro-irradiation in lymphocytes from radio-hypersensitive and non-radiosensitive patients. These results warrant future validation in larger cohorts in order to determine parameters potentially predictive for clinical radiosensitivity.

Published
2012
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47. [Side effects of radiotherapy in the oral cavity].

Author

Dörr W, Dörr E, Haagen J, Hartmann JT, Riesenbeck D, Schmidt M, and Grötz KA

Subjects
Cooperative Behavior, Dental Caries diagnosis, Dental Caries etiology, Dental Caries therapy, Humans, Interdisciplinary Communication, Mouth Diseases diagnosis, Mouth Diseases etiology, Mouth Diseases therapy, Osteoradionecrosis diagnosis, Osteoradionecrosis therapy, Radiation Injuries diagnosis, Radiation Injuries therapy, Radiotherapy Dosage, Stomatitis diagnosis, Stomatitis therapy, Mouth Neoplasms radiotherapy, Osteoradionecrosis etiology, Radiation Injuries etiology, Stomatitis etiology
Published
2010

48. Limited effects of selenium substitution in the prevention of radiation-associated toxicities. results of a randomized study in head and neck cancer patients.

Author

Büntzel J, Riesenbeck D, Glatzel M, Berndt-Skorka R, Riedel T, Mücke R, Kisters K, Schönekaes KG, Schäfer U, Bruns F, and Micke O

Subjects
Aged, Deglutition Disorders pathology, Deglutition Disorders prevention & control, Female, Humans, Male, Medical Oncology methods, Middle Aged, Mucositis prevention & control, Xerostomia prevention & control, Carcinoma, Squamous Cell radiotherapy, Head and Neck Neoplasms radiotherapy, Radiation Injuries pathology, Radiation Injuries prevention & control, Sodium Selenite pharmacology
Abstract

Objective: The substitution of selenium activates the selenium-dependent enzyme glutathione peroxidase, which is important for scavenging free radicals. To date, only limited data are available about the clinical impact of selenium regarding the toxicities due to free radical producing therapies, e.g. irradiation or chemotherapy, and therefore the objective of this study was to investigate the clinical impact of selenium in such therapies., Patients and Methods: 39 patients (8 female, 31 male) with advanced head and neck cancer were included in a randomised phase II study. The mean age was 63.52+/-9.31 years. Tumour localizations: oral cavity 15 patients, oropharynx 19 patients, hypopharynx 5 patients, carcinoma of unknown primary 1 patient. Group A (n=22) received 500 microg sodium selenite on the days of radiotherapy and 300 microg sodium selenite on days without radiotherapy. Group B (17) was irradiated without any selenium substitution. Both groups were well balanced according to age, gender, localization and stage of the tumour. The RTOG grade of radiation-associated toxicities was evaluated once per week., Results: The following serious toxicities were observed (group A vs. group B): dysphagia 22.7% vs. 35.3%, loss of taste 22.7% vs. 47.1%, dry mouth 22.7% vs. 23.5%, and stomatitis 36.4% vs. 23.5%. A statistical trend (Fisher's exact test) was only seen for the loss of taste (p=0.172). The weekly patient analysis (Student's t-test) showed a significant reduction of dysphagia in the selenium group (Group 1) at the last week of irradiation., Conclusion: This small randomised trial showed limited effects of selenium in the prevention of ageusia (loss of taste) and dysphagia due to radiotherapy of head and neck cancer.

Published
2010

49. Ovarian function following pelvic irradiation in prepubertal and pubertal girls and young adult women.

Author

Schuck A, Hamelmann V, Brämswig JH, Könemann S, Rübe C, Hesselmann S, Riesenbeck D, Horst E, Bölling T, Paulussen M, Jürgens H, and Willich N

Subjects
Adolescent, Adult, Age Factors, Bone Neoplasms radiotherapy, Chi-Square Distribution, Child, Child, Preschool, Dose Fractionation, Radiation, Female, Follow-Up Studies, Hodgkin Disease radiotherapy, Humans, Infant, Kidney Neoplasms radiotherapy, Menarche, Ovary physiology, Ovary physiopathology, Pregnancy, Radiotherapy Dosage, Retrospective Studies, Sarcoma, Ewing radiotherapy, Surveys and Questionnaires, Time Factors, Wilms Tumor radiotherapy, Neoplasms radiotherapy, Ovarian Diseases etiology, Ovary radiation effects, Puberty, Radiotherapy adverse effects
Abstract

Purpose: To analyze the effect of pelvic radiotherapy on ovarian function in prepubertal and pubertal girls and young adult women., Patients and Methods: In a retrospective monoinstitutional analysis, patients < 30 years of age at diagnosis were included who had been irradiated between 1979 and 1998. The main tumor types were Hodgkin's disease (38%), Ewing's sarcoma (20%) and nephroblastoma (11%). Patients were classified into three groups according to the position of the ovary in relation to the radiation portals. Group 1 was defined by direct irradiation of both ovaries. Group 2 patients were included with both ovaries potentially located in the radiation portals. In group 3, at least one ovary was not directly irradiated. The median follow-up was 128 months., Results: 16 of 55 analyzed patients were categorized in group 1. In ten of these patients, hormone status was evaluable. The ovarian doses were >/= 15 Gy. Except for one patient treated with 15 Gy all developed hormone failure. Eight of 14 patients of group 2 were evaluable. Seven of these patients developed ovarian failure. 19 of 24 patients in group 3 were evaluable. Nine of these patients developed ovarian failure. The observed difference in the rate of ovarian failure between the groups is statistically significant (p = 0.045)., Conclusion: All patients receiving > 15 Gy to the ovaries developed hormone failure. In one case of a patient receiving an ovarian dose of 15 Gy, hormone failure was not found. In case of pelvic irradiation excluding at least one ovary, approximately half of the patients developed ovarian dysfunction, probably also due to the effects of polychemotherapy.

Published
2005
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50. Preoperative chemotherapy with and without additional radiochemotherapy: benefit and risk for surgery of stage III non-small cell lung cancer.

Author

Semik M, Riesenbeck D, Linder A, Schmid C, Hoffknecht P, Heinecke A, Scheld H, and Thomas M

Subjects
Antineoplastic Agents therapeutic use, Carcinoma, Non-Small-Cell Lung drug therapy, Carcinoma, Non-Small-Cell Lung radiotherapy, Combined Modality Therapy methods, Female, Humans, Lung Neoplasms drug therapy, Lung Neoplasms radiotherapy, Male, Middle Aged, Neoplasm Staging, Pneumonia etiology, Postoperative Complications etiology, Preoperative Care methods, Reoperation, Respiratory Insufficiency etiology, Risk Factors, Thoracotomy methods, Treatment Outcome, Carcinoma, Non-Small-Cell Lung surgery, Lung Neoplasms surgery
Abstract

Objective: Multi-modality approaches are increasingly employed to improve prognosis in surgically treated stage III non-small cell lung cancer (NSCLC). Risk and benefit of the preoperative therapeutic chemotherapy or combined radiochemotherapy on surgical morbidity and mortality are still a matter of debate., Methods: In 1995, a national phase III trial was started to compare (arm A) preoperative chemotherapy followed by twice-daily chemoradiation and consecutive surgery, with (arm B) preoperative chemotherapy alone followed by surgery and consecutive radiotherapy. An interim analysis with 277 patients was performed to assess surgical risk and complication rates., Results: of the 358 patients, 273 (71%) underwent thoracotomy, 130 (73%) in arm A and 143 (69%) in arm B. Of the 273 patients undergoing thoracotomy, 168 had stage IIIB disease. Complete resection (R0) was achieved in 212 patients (78%), 104 in arm A (80%) and 108 in arm B (76%) (P=n.s.). There was no difference in the proportion of complex resections between treatment arms (41% in arm A; 48% in arm B). Whilst bronchial stump insufficiency (3.8 vs 2.1%) and bleeding requiring re-thoracotomy (1.5 vs 0.7%) prevailed slightly in arm A, the occurrence of pneumonia divided similar in both treatment arms (4.6 vs 4.9%). Surgical mortality reached 6.1% in arm A (8/130) and 5.6% in arm B(6/143) (P=n.s.)., Conclusions: In both treatment arms, a similar percentage of patients could be forwarded to surgery, even in stage IIIB disease. Bimodality induction seems to be superior with regard to resection rates (R0) (n.s.), but was associated with a higher complication rate, especially bronchial stump insufficiency.

Published
2004
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