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187 results on '"Rienzo, Monica"'

4. Multiple Sclerosis: From the Application of Oligoclonal Bands to Novel Potential Biomarkers.

Author

Maglio, Grazia, D'Agostino, Marina, Caronte, Francesco Pio, Pezone, Luciano, Casamassimi, Amelia, Rienzo, Monica, Di Zazzo, Erika, Nappo, Carmela, Medici, Nicola, Molinari, Anna Maria, and Abbondanza, Ciro

Subjects
IMMUNOGLOBULIN light chains, MULTIPLE sclerosis, CEREBROSPINAL fluid examination, CEREBROSPINAL fluid, BIOMARKERS, CENTRAL nervous system, NATALIZUMAB
Abstract

Multiple sclerosis is a chronic immune-mediated disorder of the central nervous system with a high heterogeneity among patients. In the clinical setting, one of the main challenges is a proper and early diagnosis for the prediction of disease activity. Current diagnosis is based on the integration of clinical, imaging, and laboratory results, with the latter based on the presence of intrathecal IgG oligoclonal bands in the cerebrospinal fluid whose detection via isoelectric focusing followed by immunoblotting represents the gold standard. Intrathecal synthesis can also be evidenced by the measurement of kappa free light chains in the cerebrospinal fluid, which has reached similar diagnostic accuracy compared to that of oligoclonal bands in the identification of patients with multiple sclerosis; moreover, recent studies have also highlighted its value for early disease activity prediction. This strategy has significant advantages as compared to using oligoclonal band detection, even though some issues remain open. Here, we discuss the current methods applied for cerebrospinal fluid analysis to achieve the most accurate diagnosis and for follow-up and prognosis evaluation. In addition, we describe new promising biomarkers, currently under investigation, that could contribute both to a better diagnosis of multiple sclerosis and to its monitoring of the therapeutic treatment response. [ABSTRACT FROM AUTHOR]

Published
2024
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9. Advances in “adiponcosis”: Insights in the inner mechanisms at the base of adipose and tumour tissues interplay

Author

Pagano, Cristina, primary, di Zazzo, Erika, additional, Avilia, Giorgio, additional, Savarese, Beatrice, additional, Navarra, Giovanna, additional, Proto, Maria Chiara, additional, Fiore, Donatella, additional, Rienzo, Monica, additional, Gazzerro, Patrizia, additional, Laezza, Chiara, additional, and Bifulco, Maurizio, additional

Published
2022
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12. Does Gut-breast Microbiota Axis Orchestrates Cancer Progression?

Author

Ballini, Andrea, primary, Santacroce, Luigi, primary, Marino, Maria Michela, additional, Nastri, Bianca Maria, additional, D’Agostino, Marina, additional, Risolo, Rossella, additional, De Angelis, Alessandra, additional, Settembre, Giuliana, additional, Rienzo, Monica, additional, D’Esposito, Vittoria, additional, Abbondanza, Ciro, additional, Formisano, Pietro, additional, Boccellino, Mariarosaria, additional, and Di Domenico, Marina, additional

Published
2022
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14. Advances in "adiponcosis": Insights in the inner mechanisms at the base of adipose and tumour tissues interplay.

Author

Pagano, Cristina, di Zazzo, Erika, Avilia, Giorgio, Savarese, Beatrice, Navarra, Giovanna, Proto, Maria Chiara, Fiore, Donatella, Rienzo, Monica, Gazzerro, Patrizia, Laezza, Chiara, and Bifulco, Maurizio

Subjects
ADIPOSE tissues, SOMATOMEDIN, THERAPEUTICS, FAT, DISEASE risk factors, OBESITY
Abstract

The epidemic spread of obesity is nowadays recognized as a global health and economic burden, arising great interest in the scientific community. The rate of adult obesity steadily increases concomitantly with the cancer incidence. As has been comprehensively reported, obesity is included among the multiple cancer risk factors and can progressively cause and/or exacerbate certain cancer types, as colorectal and breast cancers. The term adiponcosis was forged precisely to emphasize the interconnection between obesity and cancer onset and progression. The underlying mechanisms of adiponcosis have not been fully elucidated yet, may vary on cancer type, and depend on body fat distribution. It has been proposed that insulin resistance and related chronic hyperinsulinemia, increased insulin‐like growth factors production, chronic inflammation or increased bioavailability of steroid hormones could be responsible of cancer hallmarks. Additionally, it has been suggested that adipose tissue‐derived hormones, cytokines and adipokines, such as leptin, adiponectin and inflammatory markers, may reflect mechanisms linked to tumorigenesis. This review summarizes the current evidence on pathways, hormones, cytokines and low‐chronic inflammation subtending adiponconsis, focusing on breast and colorectal cancers. In addition, we analyzed the lifestyle interventions that could attenuate the driving forces of obesity‐related cancer incidence and progression. Moreover, current targets and drugs, their pros and cons, as well as new mechanisms and targets with promising therapeutic potential in cancer are discussed. Depicting this complex interconnection will provide insights for establishing new therapeutic approaches to halt the obesity impacts and thwart cancer onset and progression. [ABSTRACT FROM AUTHOR]

Published
2023
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15. Detrimental Effects of Bartonella henselae Are Counteracted by L-Arginine and Nitric Oxide in Human Endothelial Progenitor Cells

Author

Salvatore, Paola, Casamassimi, Amelia, Sommese, Linda, Fiorito, Carmela, Ciccodicola, Alfredo, Rossiello, Raffaele, Avallone, Bice, Grimaldi, Vincenzo, Costa, Valerio, Rienzo, Monica, Colicchio, Roberta, Williams-Ignarro, Sharon, Pagliarulo, Caterina, Prudente, Maria Evelina, Abbondanza, Ciro, Lamberti, Florentia, Baroni, Adone, Buommino, Elisabetta, Farzati, Bartolomeo, Tufano, Maria Antonietta, Ignarro, Louis Joseph, and Napoli, Claudio

Published
2008
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17. Searching for a putative mechanism of tumor-promoting function of RIZ2 in cancer models

Author

Rienzo Monica, Sorrentino Anna, Di Zazzo Erika, Di Donato Marzia, Carafa Vincenzo, Marino Maria Michela, De Rosa Caterina, Gazzerro Patrizia, Castoria Gabriella, Altucci Lucia, Casamassimi Amelia, Abbondanza Ciro, Rienzo, Monica, Sorrentino, Anna, Di Zazzo, Erika, DI DONATO, Marzia, Carafa, Vincenzo, Marino Maria, Michela, De Rosa, Caterina, Gazzerro, Patrizia, Castoria, Gabriella, Altucci, Lucia, Casamassimi, Amelia, and Abbondanza, Ciro

Abstract

Positive Regulatory Domain (PRDM) gene family members commonly express two main molecular variants, the PR-plus isoform usually acting as tumor suppressor and the PR-minus one functioning as oncogene. Accordingly, PRDM2/RIZ encodes for RIZ1 (PR-plus) and RIZ2 (PR-minus). In human cancers, genetic or epigenetic modifications induce RIZ1 silencing with an expression level imbalance in favor of RIZ2 that could be relevant for tumorigenesis. Additionally, in estrogen target cells and tissues, estradiol increases RIZ2 expression level with concurrent increase of cell proliferation and survival. Several attempts to study RIZ2 function in HeLa or MCF-7 cells by its over-expression were unsuccessful. Thus, we over-expressed RIZ2 in HEK-293 cells, which are both RIZ1 and RIZ2 positive but unresponsive to estrogens. The forced RIZ2 expression increased cell viability and growth, prompted the G2-to-M phase transition and organoids formation. Accordingly, microarray analysis revealed that RIZ2 regulates several genes involved in mitosis. Consistently, RIZ silencing in both estrogen-responsive MCF-7 and –unresponsive MDA-MB-231 cells induced a reduction of cell proliferation and an increase of apoptosis rate. Our findings add novel insights on the putative RIZ2 tumor-promoting functions, although additional attempts are warranted to depict the underlying molecular mechanism.

Published
2021

19. Therapeutic angiogenesis in diabetic apolipoprotein E-deficient mice using bone marrow cells, functional hemangioblasts and metabolic intervention

Author

Balestrieri, Maria Luisa, Lu, Shi-Jiang, de Nigris, Filomena, Giovane, Alfonso, Williams-Ignarro, Sharon, D’Armiento, Francesco Paolo, Feng, Qiang, Fiorito, Carmela, Testa, Gianluca, Pastore, Lucio, Cacciatore, Francesco, Mancini, Francesco Paolo, Servillo, Luigi, De Rosa, Gaetano, Pagliarulo, Caterina, Rienzo, Monica, Minucci, Pellegrino Biagio, Farzati, Bartolomeo, Salvatore, Francesco, Rengo, Franco, Ignarro, Louis Joseph, Giordano, Antonio, Baker, Andrew, Lanza, Robert, and Napoli, Claudio

Published
2010
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21. PRDM12 in Health and Diseases

Author

Rienzo, Monica, primary, Di Zazzo, Erika, additional, Casamassimi, Amelia, additional, Gazzerro, Patrizia, additional, Perini, Giovanni, additional, Bifulco, Maurizio, additional, and Abbondanza, Ciro, additional

Published
2021
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27. Searching for a Putative Mechanism of RIZ2 Tumor-Promoting Function in Cancer Models

Author

Rienzo, Monica, primary, Sorrentino, Anna, additional, Di Zazzo, Erika, additional, Di Donato, Marzia, additional, Carafa, Vincenzo, additional, Marino, Maria Michela, additional, De Rosa, Caterina, additional, Gazzerro, Patrizia, additional, Castoria, Gabriella, additional, Altucci, Lucia, additional, Casamassimi, Amelia, additional, and Abbondanza, Ciro, additional

Published
2021
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28. Multifaceted Role of PRDM Proteins in Human Cancer

Author

Casamassimi, Amelia, primary, Rienzo, Monica, additional, Di Zazzo, Erika, additional, Sorrentino, Anna, additional, Fiore, Donatella, additional, Proto, Maria Chiara, additional, Moncharmont, Bruno, additional, Gazzerro, Patrizia, additional, Bifulco, Maurizio, additional, and Abbondanza, Ciro, additional

Published
2020
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29. Mobile Screening Units for the Early Detection of Breast Cancer and Cardiovascular Disease: A Pilot Telemedicine Study in Southern Italy

Author

Marino, Maria Michela, primary, Rienzo, Monica, additional, Serra, Nicola, additional, Marino, Nicola, additional, Ricciotti, Raffaella, additional, Mazzariello, Luigi, additional, Leonetti, Concetta Anna, additional, Ceraldi, Maria Palma, additional, Casamassimi, Amelia, additional, Capocelli, Francesca, additional, Martone, Gennaro, additional, and Caracciolo, Aniello Leonardo, additional

Published
2020
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31. Impairment of circulating endothelial progenitors in Down syndrome

Author

Costa Valerio, Sommese Linda, Casamassimi Amelia, Colicchio Roberta, Angelini Claudia, Marchesano Valentina, Milone Lara, Farzati Bartolomeo, Giovane Alfonso, Fiorito Carmela, Rienzo Monica, Picardi Marco, Avallone Bice, Marco Corsi Massimiliano, Sarubbi Berardo, Calabrò Raffaele, Salvatore Paola, Ciccodicola Alfredo, and Napoli Claudio

Subjects
Internal medicine, RC31-1245, Genetics, QH426-470
Abstract

Abstract Background Pathological angiogenesis represents a critical issue in the progression of many diseases. Down syndrome is postulated to be a systemic anti-angiogenesis disease model, possibly due to increased expression of anti-angiogenic regulators on chromosome 21. The aim of our study was to elucidate some features of circulating endothelial progenitor cells in the context of this syndrome. Methods Circulating endothelial progenitors of Down syndrome affected individuals were isolated, in vitro cultured and analyzed by confocal and transmission electron microscopy. ELISA was performed to measure SDF-1α plasma levels in Down syndrome and euploid individuals. Moreover, qRT-PCR was used to quantify expression levels of CXCL12 gene and of its receptor in progenitor cells. The functional impairment of Down progenitors was evaluated through their susceptibility to hydroperoxide-induced oxidative stress with BODIPY assay and the major vulnerability to the infection with human pathogens. The differential expression of crucial genes in Down progenitor cells was evaluated by microarray analysis. Results We detected a marked decrease of progenitors' number in young Down individuals compared to euploid, cell size increase and some major detrimental morphological changes. Moreover, Down syndrome patients also exhibited decreased SDF-1α plasma levels and their progenitors had a reduced expression of SDF-1α encoding gene and of its membrane receptor. We further demonstrated that their progenitor cells are more susceptible to hydroperoxide-induced oxidative stress and infection with Bartonella henselae. Further, we observed that most of the differentially expressed genes belong to angiogenesis, immune response and inflammation pathways, and that infected progenitors with trisomy 21 have a more pronounced perturbation of immune response genes than infected euploid cells. Conclusions Our data provide evidences for a reduced number and altered morphology of endothelial progenitor cells in Down syndrome, also showing the higher susceptibility to oxidative stress and to pathogen infection compared to euploid cells, thereby confirming the angiogenesis and immune response deficit observed in Down syndrome individuals.

Published
2010
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33. NEXT GENERATION SEQUENCING AND CARDIAC TRANSPLANTATION

Author

Grimaldi, Vincenzo, Rienzo, Monica, Picascia, Antonietta, Schiano, Concetta, Costa, Valerio, Ciccodicola, Alfredo, Pignalosa, Orlando, Pascale, Maria Rosaria, Cristiano Amarelli, Maiello, Ciro, Napoli, Claudio, Grimaldi, Vincenzo, Rienzo, Monica, Picascia, Antonietta, Schiano, Concetta, Costa, Valerio, Ciccodicola, Alfredo, Pignalosa, Orlando, Rosaria De Pascale, Maria, Cristianoamarelli, Maiello, Ciro, and Napoli, Claudio

Published
2015

37. P089

Author

Grimaldi, Vincenzo, primary, Schiano, Concetta, additional, Rienzo, Monica, additional, Casamassimi, Amelia, additional, Picascia, Antonietta, additional, Amarelli, Cristiano, additional, Maiello, Ciro, additional, and Napoli, Claudio, additional

Published
2014
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41. 185-P

Author

Rienzo, Monica, primary, Picascia, Antonietta, additional, Schiano, Concetta, additional, Casamassimi, Amelia, additional, Grimaldi, Vincenzo, additional, and Napoli, Claudio, additional

Published
2013
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43. Glycoxydation promotes vascular damage Via MAPK-ERK/JNK pathways

Author

de Nigris, Filomena, primary, Rienzo, Monica, additional, Sessa, Marcella, additional, Infante, Teresa, additional, Cesario, Elena, additional, Ignarro, Louis J., additional, Al-Omran, Mohammed, additional, Giordano, Antonio, additional, Palinski, Wulf, additional, and Napoli, Claudio, additional

Published
2012
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44. Massive-Scale RNA-Seq Analysis of Non Ribosomal Transcriptome in Human Trisomy 21

Author

Costa, Valerio, primary, Angelini, Claudia, additional, D'Apice, Luciana, additional, Mutarelli, Margherita, additional, Casamassimi, Amelia, additional, Sommese, Linda, additional, Gallo, Maria Assunta, additional, Aprile, Marianna, additional, Esposito, Roberta, additional, Leone, Luigi, additional, Donizetti, Aldo, additional, Crispi, Stefania, additional, Rienzo, Monica, additional, Sarubbi, Berardo, additional, Calabrò, Raffaele, additional, Picardi, Marco, additional, Salvatore, Paola, additional, Infante, Teresa, additional, De Berardinis, Piergiuseppe, additional, Napoli, Claudio, additional, and Ciccodicola, Alfredo, additional

Published
2011
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46. Antioxidants increase number of progenitor endothelial cells through multiple gene expression pathways

Author

Fiorito, Carmela, primary, Rienzo, Monica, additional, Crimi, Ettore, additional, Rossiello, Raffaele, additional, Luisa Balestrieri, Maria, additional, Casamassimi, Amelia, additional, Muto, Francesco, additional, Grimaldi, Vincenzo, additional, Giovane, Alfonso, additional, Farzati, Bartolomeo, additional, Mancini, Francesco P., additional, and Napoli, Claudio, additional

Published
2008
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47. p66ShcDeletion Confers Vascular Protection in Advanced Atherosclerosis in Hypercholesterolemic Apolipoprotein E Knockout Mice

Author

Martin-Padura, Ines, primary, de Nigris, Filomena, additional, Migliaccio, Enrica, additional, Mansueto, Gelsomina, additional, Minardi, Simone, additional, Rienzo, Monica, additional, Lerman, Lilach O., additional, Stendardo, Massimo, additional, Giorgio, Marco, additional, De Rosa, Gaetano, additional, Pelicci, Pier Giuseppe, additional, and Napoli, Claudio, additional

Published
2008
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48. Experimental colitis: decreased Octn2 and Atb0+ expression in rat colonocytes induces carnitine depletion that is reversible by carnitine‐loaded liposomes

Author

D'Argenio, Giuseppe, primary, Calvani, Menotti, additional, Casamassimi, Amelia, additional, Petillo, Orsolina, additional, Margarucci, Sabrina, additional, Rienzo, Monica, additional, Peluso, Ivana, additional, Calvani, Riccardo, additional, Ciccodicola, Alfredo, additional, Caporaso, Nicola, additional, Peluso, Gianfranco, additional, and D'Argenio, Giuseppe, additional

Published
2006
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