240 results on '"Riendeau D"'
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2. Leukotrienes and Asthma
3. Catalytic Properties and Reaction Mechanism of 5-Lipoxygenase
4. Characterization of autocrine inducible prostaglandin H synthase-2 (PGHS-2) in human osteosarcoma cells
5. Comparison of the cyclooxygenase-1 inhibitory properties of nonsteroidal anti-inflammatory drugs and selective COX-2 inhibitors, using sensitive microsomal and platelet assays
6. Cloning and expression of rhesus monkey cathepsin K
7. SAR in the alkoxy lactone series: the discovery of DFP, a potent and orally active COX-2 inhibitor
8. The discovery of rofecoxib, [MK 966, VIOXX ®, 4-(4′-methylsulfonylphenyl)-3-phenyl-2(5 H)-furanone], an orally active cyclooxygenase-2 inhibitor
9. Enzymatic reduction of fatty acids and acyl-CoAs to long chain aldehydes and alcohols
10. Biochemical and pharmacological profile of a tetrasubstituted furanone as a highly selective COX-2 inhibitor
11. ChemInform Abstract: Substituted Thiopyrano(2,3,4-c,d)indoles as Potent, Selective, and Orally Active Inhibitors of 5-Lipoxygenase. Synthesis and Biological Evaluation of L-691,816.
12. The discovery of rofecoxib, [MK 966, VIOXX®, 4-(4′-methylsulfonylphenyl)-3-phenyl-2(5H)-furanone], an orally active cyclooxygenase-2 inhibitor
13. Characterization of rofecoxib as a cyclooxygenase-2 isoform inhibitor and demonstration of analgesia in the dental pain model
14. ChemInform Abstract: Synthesis and Biological Evaluation of 5,6‐Diarylimidazo(2.1‐b) thiazole as Selective COX‐2 Inhibitors.
15. Biochemical and pharmacological profile of a tetrasubstituted furanone as a highly selective COX-2 inhibitor
16. ChemInform Abstract: Novel 1,2‐Diarylcyclobutenes: Selective and Orally Active COX‐2 Inhibitors.
17. ChemInform Abstract: Dioxabicyclooctanyl Naphthalenenitriles as Nonredox 5‐Lipoxygenase Inhibitors: Structure‐Activity Relationship Study Directed Toward the Improvement of Metabolic Stability.
18. Characterization of Prostaglandin G/H Synthase 1 and 2 in rat, dog, monkey, and human gastrointestinal tracts
19. ChemInform Abstract: Synthesis and Biological Evaluation of 2,3‐Diarylthiophenes as Selective COX‐2 Inhibitors. Part 2. Replacing the Heterocycle
20. ChemInform Abstract: Thiopyranol(2,3,4‐c,d)indoles as Inhibitors of 5‐Lipoxygenase, 5‐ Lipoxygenase‐Activating Protein, and Leukotriene C4 Synthase.
21. ChemInform Abstract: Synthesis and Biological Evaluation of 2,3‐Diarylthiophenes as Selective Cox‐2 and Cox‐1 Inhibitors.
22. Involvement of cyclooxygenase 2 (COX-2) in intrinsic tone of isolated guinea pig
23. ChemInform Abstract: Thiopyrano(2,3,4‐cd)indoles as 5‐Lipoxygenase Inhibitors: Synthesis, Biological Profile, and Resolution of 2‐(2‐(1‐(4‐Chlorobenzyl)‐4‐ methyl‐6‐((5‐phenylpyridin‐2‐yl)methoxy)‐4,5‐dihydro‐1H‐thiopyrano(2,3, 4‐cd)indol‐2‐yl)ethoxy)butanoic Acid.
24. Arachidonyl trifluoromethyl ketone, a potent inhibitor of 85-kDa phospholipase A2, blocks production of arachidonate and 12-hydroxyeicosatetraenoic acid by calcium ionophore-challenged platelets.
25. Thiopyrano[2,3,4-cd]indoles as 5-Lipoxygenase Inhibitors: Synthesis, Biological Profile, and Resolution of 2-[2-[1-(4-Chlorobenzyl)-4-methyl-6-[(5-phenylpyridin-2-yl)methoxy]-4,5-dihydro-1H-thiopyrano[2,3,4-cd]indol-2-yl]ethoxy]butanoic Acid
26. Identification of 5-Keto-(7E,9E,11Z,14Z)-Eicosatetraenoic Acid as a Novel Nonenzymatic Rearrangement Product of Leukotriene A4
27. Justicidin E: A new leukotriene biosynthesis inhibitor.
28. Substituted thiopyrano[2,3,4-c,d]indoles as potent, selective, and orally active inhibitors of 5-lipoxygenase. Synthesis and biological evaluation of L-691,816
29. Characterization of the iron binding site in human 5-lipoxygenase by EPR spectroscopy
30. Development of L-689,065 - the prototype of a new class of potent 5-lipoxygenase inhibitors
31. A new class of leukotriene biosynthesis inhibitors: The discovery of MK0591
32. Pharmacology of MK-0591 (3-[1-(4-chlorobenzyl)-3-(t-butylthio)-5-(quinolin-2-yl-methoxy)-indol-2-yl]-2,2-dimethyl propanoic acid), a potent, orally active leukotriene biosynthesis inhibitor
33. Nitroxide metabolites from alkylhydroxylamines and N-hydroxyurea derivatives resulting from reductive inhibition of soybean lipoxygenase.
34. Modeling, simulation, and design methodology of the interconnect and packaging of an ultra-high speed source synchronous bus.
35. Evaluation of the role of conserved His and Met residues among lipoxygenases by site-directed mutagenesis of recombinant human 5-lipoxygenase.
36. Characterization of the activity of purified recombinant human 5-lipoxygenase in the absence and presence of leukocyte factors.
37. Pseudoperoxidase activity of 5-lipoxygenase stimulated by potent benzofuranol and N-hydroxyurea inhibitors of the lipoxygenase reaction
38. New technology applications: thrombolysis of acute deep vein thrombosis.
39. ChemInform Abstract: Synthesis of Two Analogues of Arachidonic Acid and Their Reactions with 12‐Lipoxygenase.
40. Lysosomotropism of Basic Cathepsin K Inhibitors Contributes to Increased Cellular Potencies against Off-Target Cathepsins and Reduced Functional Selectivity
41. Design and Synthesis of Tri-Ring P<INF>3</INF> Benzamide-Containing Aminonitriles as Potent, Selective, Orally Effective Inhibitors of Cathepsin K
42. Novel, Nonpeptidic Cyanamides as Potent and Reversible Inhibitors of Human Cathepsins K and L
43. Effects of COX-2 inhibitors on aortic prostacyclin production in cholesterol-fed rabbits
44. In vitro metabolism considerations, including activity testing of metabolites, in the discovery and selection of the COX-2 inhibitor etoricoxib (MK-0663)
45. Expression, maturation, and rhodamine-based fluorescence assay of human cathepsin K expressed in CHO cells
46. 2,3-Diarylcyclopentenones as Orally Active, Highly Selective Cyclooxygenase-2 Inhibitors
47. Substituted Heterocyclic Analogs as Selective COX-2 Inhibitors in the Flosulide Class
48. 2-Heterosubstituted-3-(4-methylsulfonyl)phenyl-5-trifluoromethyl pyridines as selective and orally active cyclooxygenase-2 inhibitors
49. Phosphodiesterase 4-dependent regulation of cyclic AMP levels and leukotriene B~4 biosynthesis in human polymorphonuclear leukocytes
50. Mechanism of selective inhibition of human prostaglandin G/H synthase-1 and -2 in intact cells
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