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4. Inflammatory Response to Chronic Opioid Exposure in Humans

Author

Mathi, Kavita, primary, Dobrota, Sylvie D, additional, Lee, Timothy J, additional, Sayyid, Zahra N, additional, Rouholiman, Dara, additional, Gamble, Jamison G, additional, Encisco, Ellen M, additional, Rico, Tom, additional, Maecker, Holden T, additional, and Chu, Larry F, additional

Published
2020
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5. Reply to Dr Peltz

Author

Chu, Larry F., primary, Sun, John, additional, Clemenson, Anna, additional, Erlendson, Matthew J., additional, Rico, Tom, additional, Cornell, Erika, additional, Obasi, Hannah, additional, Sayyid, Zahra N., additional, Encisco, Ellen M., additional, Yu, Jeff, additional, Gamble, Jamison G., additional, and Clark, J. David, additional

Published
2018
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7. Familial Kleine-Levin Syndrome: A Specific Entity?

Author

Nguyen, Quang Tuan Remy, primary, Groos, Elisabeth, additional, Leclair-Visonneau, Laurène, additional, Monaca-Charley, Christelle, additional, Rico, Tom, additional, Farber, Neal, additional, Mignot, Emmanuel, additional, and Arnulf, Isabelle, additional

Published
2016
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8. ImmunoChip Study Implicates Antigen Presentation to T Cells in Narcolepsy

Author

Faraco, Juliette, Lin, Ling, Kornum, Birgitte Rahbek, Kenny, Eimear E, Trynka, Gosia, Einen, Mali, Rico, Tom J, Lichtner, Peter, Dauvilliers, Yves, Arnulf, Isabelle, Lecendreux, Michel, Javidi, Sirous, Geisler, Peter, Mayer, Geert, Pizza, Fabio, Poli, Francesca, Plazzi, Giuseppe, Overeem, Sebastiaan, Lammers, Gert Jan, Kemlink, David, Sonka, Karel, Nevsimalova, Sona, Rouleau, Guy, Desautels, Alex, Montplaisir, Jacques, Frauscher, Birgit, Ehrmann, Laura, Högl, Birgit, Jennum, Poul, Bourgin, Patrice, Peraita-Adrados, Rosa, Iranzo, Alex, Bassetti, Claudio, Chen, Wei-Min, Concannon, Patrick, Thompson, Susan D, Damotte, Vincent, Fontaine, Bertrand, Breban, Maxime, Gieger, Christian, Klopp, Norman, Deloukas, Panos, Wijmenga, Cisca, Hallmayer, Joachim, Onengut-Gumuscu, Suna, Rich, Stephen S, Winkelmann, Juliane, Mignot, Emmanuel, Faraco, Juliette, Lin, Ling, Kornum, Birgitte Rahbek, Kenny, Eimear E, Trynka, Gosia, Einen, Mali, Rico, Tom J, Lichtner, Peter, Dauvilliers, Yves, Arnulf, Isabelle, Lecendreux, Michel, Javidi, Sirous, Geisler, Peter, Mayer, Geert, Pizza, Fabio, Poli, Francesca, Plazzi, Giuseppe, Overeem, Sebastiaan, Lammers, Gert Jan, Kemlink, David, Sonka, Karel, Nevsimalova, Sona, Rouleau, Guy, Desautels, Alex, Montplaisir, Jacques, Frauscher, Birgit, Ehrmann, Laura, Högl, Birgit, Jennum, Poul, Bourgin, Patrice, Peraita-Adrados, Rosa, Iranzo, Alex, Bassetti, Claudio, Chen, Wei-Min, Concannon, Patrick, Thompson, Susan D, Damotte, Vincent, Fontaine, Bertrand, Breban, Maxime, Gieger, Christian, Klopp, Norman, Deloukas, Panos, Wijmenga, Cisca, Hallmayer, Joachim, Onengut-Gumuscu, Suna, Rich, Stephen S, Winkelmann, Juliane, and Mignot, Emmanuel

Published
2013

9. Predictors of hypocretin (orexin) deficiency in narcolepsy without cataplexy

Author

Andlauer, Olivier, Moore, Hyatt, Hong, Seung-Chul, Dauvilliers, Yves, Kanbayashi, Takashi, Nishino, Seiji, Han, Fang, Silber, Michael H, Rico, Tom, Einen, Mali, Kornum, Birgitte R, Jennum, Poul, Knudsen, Stine, Nevsimalova, Sona, Poli, Francesca, Plazzi, Giuseppe, Mignot, Emmanuel, Andlauer, Olivier, Moore, Hyatt, Hong, Seung-Chul, Dauvilliers, Yves, Kanbayashi, Takashi, Nishino, Seiji, Han, Fang, Silber, Michael H, Rico, Tom, Einen, Mali, Kornum, Birgitte R, Jennum, Poul, Knudsen, Stine, Nevsimalova, Sona, Poli, Francesca, Plazzi, Giuseppe, and Mignot, Emmanuel

Abstract

Study Objectives:Retrospective comparison and receiver operating characteristics curve analysis. Patients were also recontacted to evaluate if they developed cataplexy by survival curve analysis.Measurements and Results:

Published
2012

10. DQB1*06:02 allele-specific expression varies by allelic dosage, not narcolepsy status

Author

Weiner Lachmi, Karin, Lin, Ling, Kornum, Birgitte Rahbek, Rico, Tom, Lo, Betty, Aran, Adi, Mignot, Emmanuel, Weiner Lachmi, Karin, Lin, Ling, Kornum, Birgitte Rahbek, Rico, Tom, Lo, Betty, Aran, Adi, and Mignot, Emmanuel

Abstract

The association of narcolepsy-cataplexy, a sleep disorder caused by the loss of hypocretin/orexin neurons in the hypothalamus, with DQA1*01:02-DQB1*06:02 is one of the tightest known single-allele human leukocyte antigen (HLA) associations. In this study, we explored genome-wide expression in peripheral white blood cells of 50 narcolepsy versus 47 controls (half of whom were DQB1*06:02 positive) and observed the largest differences between the groups in the signal from HLA probes. Further studies of HLA-DQ expression (mRNA and protein in a subset) in 125 controls and 147 narcolepsy cases did not reveal any difference, a result we explain by the lack of proper control of allelic diversity in Affymetrix HLA probes. Rather, a clear effect of DQB1*06:02 allelic dosage on DQB1*06:02 mRNA levels (1.65-fold) and protein (1.59-fold) could be demonstrated independent of disease status. These results indicate that allelic dosage is transmitted into changes in heterodimer availability, a phenomenon that may explain the increased risk for narcolepsy in DQB1*06:02 homozygotes versus heterozygotes.

Published
2012

11. Genome-wide association study ofHLA-DQB1*06:02negative essential hypersomnia

Author

Khor, Seik-Soon, primary, Miyagawa, Taku, additional, Toyoda, Hiromi, additional, Yamasaki, Maria, additional, Kawamura, Yoshiya, additional, Tanii, Hisashi, additional, Okazaki, Yuji, additional, Sasaki, Tsukasa, additional, Lin, Ling, additional, Faraco, Juliette, additional, Rico, Tom, additional, Honda, Yutaka, additional, Honda, Makoto, additional, Mignot, Emmanuel, additional, and Tokunaga, Katsushi, additional

Published
2013
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12. ImmunoChip Study Implicates Antigen Presentation to T Cells in Narcolepsy

Author

Faraco, Juliette, primary, Lin, Ling, additional, Kornum, Birgitte Rahbek, additional, Kenny, Eimear E., additional, Trynka, Gosia, additional, Einen, Mali, additional, Rico, Tom J., additional, Lichtner, Peter, additional, Dauvilliers, Yves, additional, Arnulf, Isabelle, additional, Lecendreux, Michel, additional, Javidi, Sirous, additional, Geisler, Peter, additional, Mayer, Geert, additional, Pizza, Fabio, additional, Poli, Francesca, additional, Plazzi, Giuseppe, additional, Overeem, Sebastiaan, additional, Lammers, Gert Jan, additional, Kemlink, David, additional, Sonka, Karel, additional, Nevsimalova, Sona, additional, Rouleau, Guy, additional, Desautels, Alex, additional, Montplaisir, Jacques, additional, Frauscher, Birgit, additional, Ehrmann, Laura, additional, Högl, Birgit, additional, Jennum, Poul, additional, Bourgin, Patrice, additional, Peraita-Adrados, Rosa, additional, Iranzo, Alex, additional, Bassetti, Claudio, additional, Chen, Wei-Min, additional, Concannon, Patrick, additional, Thompson, Susan D., additional, Damotte, Vincent, additional, Fontaine, Bertrand, additional, Breban, Maxime, additional, Gieger, Christian, additional, Klopp, Norman, additional, Deloukas, Panos, additional, Wijmenga, Cisca, additional, Hallmayer, Joachim, additional, Onengut-Gumuscu, Suna, additional, Rich, Stephen S., additional, Winkelmann, Juliane, additional, and Mignot, Emmanuel, additional

Published
2013
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13. Predictors of Hypocretin (Orexin) Deficiency in Narcolepsy Without Cataplexy

Author

Andlauer, Olivier, primary, Moore, Hyatt, additional, Hong, Seung-Chul, additional, Dauvilliers, Yves, additional, Kanbayashi, Takashi, additional, Nishino, Seiji, additional, Han, Fang, additional, Silber, Michael H., additional, Rico, Tom, additional, Einen, Mali, additional, Kornum, Birgitte R., additional, Jennum, Poul, additional, Knudsen, Stine, additional, Nevsimalova, Sona, additional, Poli, Francesca, additional, Plazzi, Giuseppe, additional, and Mignot, Emmanuel, additional

Published
2012
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15. A Flawed Design Produces Flawed Results.

Author

Peltz, Gary, Chu, Larry F., Sun, John, Clemenson, Anna, Erlendson, Matthew J., Rico, Tom, Cornell, Erika, Obasi, Hannah, Sayyid, Zahra N., Encisco, Ellen M., Yu, Jeff, Gamble, Jamison G., and Clark, J. David

Published
2018
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16. Genome-wide association study of HLA-DQB1*06:02 negative essential hypersomnia.

Author

Khor SS, Miyagawa T, Toyoda H, Yamasaki M, Kawamura Y, Tanii H, Okazaki Y, Sasaki T, Lin L, Faraco J, Rico T, Honda Y, Honda M, Mignot E, and Tokunaga K

Abstract

Essential hypersomnia (EHS), a sleep disorder characterized by excessive daytime sleepiness, can be divided into two broad classes based on the presence or absence of the HLA-DQB1*06:02 allele. HLA-DQB1*06:02-positive EHS and narcolepsy with cataplexy are associated with the same susceptibility genes. In contrast, there are fewer studies of HLA-DQB1*06:02 negative EHS which, we hypothesized, involves a different pathophysiological pathway than does narcolepsy with cataplexy. In order to identify susceptibility genes associated with HLA-DQB1*06:02 negative EHS, we conducted a genome-wide association study (GWAS) of 125 unrelated Japanese EHS patients lacking the HLA-DQB1*06:02 allele and 562 Japanese healthy controls. A comparative study was also performed on 268 HLA-DQB1*06:02 negative Caucasian hypersomnia patients and 1761 HLA-DQB1*06:02 negative Caucasian healthy controls. We identified three SNPs that each represented a unique locus- rs16826005 (P = 1.02E-07; NCKAP5), rs11854769 (P = 6.69E-07; SPRED1), and rs10988217 (P = 3.43E-06; CRAT) that were associated with an increased risk of EHS in this Japanese population. Interestingly, rs10988217 showed a similar tendency in its association with both HLA-DQB1*06:02 negative EHS and narcolepsy with cataplexy in both Japanese and Caucasian populations. This is the first GWAS of HLA-DQB1*06:02 negative EHS, and the identification of these three new susceptibility loci should provide additional insights to the pathophysiological pathway of this condition.

Published
2013
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