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*Karahaliloğlu, Zeynep ( Aksaray, Yazar ), Nosocominal infections associated with biofilm formation on urinary catheters cause serious complications. The aim of this study was to investigate the feasibility of the polyurethane (PU) catheter modified with tetracycline hydrochloride (TCH) attached Ag nanoparticles embedded PolyRicinoleic acid-Polystyrene Nanoparticles (PU-TCH-AgNPs-PRici-PS NPs) and the influence on antimicrobial and antibiofilm activity of urinary catheters infected by Escherichia coli and Staphylococcus aureus. For this purpose, AgNPs embedded PRici graft PS graft copolymers (AgNPs-PRici-g-PS) were synthesized via free radical polymerization and characterized by FTIR, HNMR and DSC. AgNPs-PRici-PS NPs were prepared and optimized by the different parameters and the optimized size of nanoparticle was found as about 150 +/- 1 nm. The characterization of the nanoparticles and the morphological evaluation were carried out by FTIR and SEM. Short term stability of nanoparticles was realised at 4 degrees C for 30 days. In vitro release profiles of TCH and Ag NPs were also investigated. The formation of biofilm on PU modified TCH-Ag NPs-PRici-PS NPs, was evaluated and the biocompatibility test of the nanoparticles was realized via the mouse fibroblast (L929) and mouse urinary bladder cells (G/G An1). This is the first time that TCH-AgNPs-PRici-PS NPs used in the modification of PU catheter demonstrated high antimicrobial and antibiofilm activities against the urinary tract infection.

Els greixos vegetals són una important matèria primera renovable per a la indústria química. Dins d'aquest grup destaquen els àcids grassos homoalílics hidroxilats com l’àcid ricinoleic o l’àcid lesqueròlic, els quals donen lloc a una gran quantitat de derivats amb múltiples aplicacions tant industrials com farmacèutiques. Aquesta tesi es va centrar, d’una banda, en l’obtenció d’àcids grassos carbonil α,β-insaturats mitjançant oxidacions més selectives i en un sol pas del grup hidroxil d’aquests àcids. D’altra banda, es va procedir a l’obtenció de l’àcid sebàcic, un àcid dicarboxílic amb gran interès industrial, a partir dels àcids grassos carbonil α,β-insaturats anteriorment sintetitzats. Finalment, es van dissenyar i sintetitzar noves N-vanillil acilamides de cadena llarga a partir dels àcids ricinoleic i lesqueròlic amb l’objectiu de desenvolupar una nova família de molècules que presentessin activitat biològica dual davant de receptors del dolor com són el receptor TRPV1 i l’enzim FAAH. Las grasas vegetales son una importante materia prima renovable para la industria química. Dentro de este grupo destacan los ácidos grasos homoalílicos hidroxilados como el ácido ricinoléico o el ácido lesquerólico, los cuales dan lugar a una gran cantidad de derivados con múltiples aplicaciones tanto industriales como farmacéuticas. Esta tesis se centró, por un lado, en la obtención de ácidos grasos carbonilo α,β-insaturados a través de oxidaciones más selectivas y en un solo paso del grupo hidroxilo de dichos ácidos. Por otro lado, se procedió a la obtención del ácido sebácico, un ácido dicarboxílico con gran interés industrial, a partir de los ácidos grasos carbonilo α,β-insaturados anteriormente sintetizados. Por último, se diseñaron y sintetizaron nuevas N-vanillil acilamidas de cadena larga (LCNVAs) a partir de los ácidos ricinoléico y lesquerólico con el objetivo de desarrollar una nueva familia de moléculas que presentaran actividad biológica dual frente a receptores del dolor como son el receptor TRPV1 y la enzima FAAH. Vegetable oils are an important renewable raw material for the chemical industry. Homoallyl hydroxy fatty acids such as ricinoleic or lesquerolic acid are highlighted within this oils. They lead to a large number of derivatives with multiple applications, both industrial and pharmaceutical. This work was focused on obtaining and using α,β-unsaturated carbonyl fatty acids through selective processes. First at all, an one-step oxidations of the hydroxy group of these acids were studied. Subsequently, sebacic acid was obtained from the α,β-unsaturated carbonyl fatty acids previously synthesized. This dicarboxylic acid has a great industrial interest. Finally, new long-chain N-vanillyl acylamides (LCNVAs) were designed and synthesized from ricinoleic and lesquerolic acid with the aim of developing a new family of molecules exhibiting dual biological activity against pain receptors such as the TRPV1 receptor and the FAAH enzyme.