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2. 2019 ESC/EAS Guidelines for the management of dyslipidaemias

Author

Mach, F., Baigent, C., Catapano, A.L., Koskinas, K.C., Casula, M., Badimon, L., Chapman, M.J., Backer, G.G. de, Delgado, V., Ference, B.A., Graham, I.M., Halliday, A., Landmesser, U., Mihaylova, B., Pedersen, T.R., Riccardi, G., Richter, D.J., Sabatine, M.S., Taskinen, M.R., Tokgozoglu, L., Wiklund, O., Nibouche, D., Zelveian, P.H., Siostrzonek, P., Najafov, R., Borne, P. van de, Pojskic, B., Postadzhiyan, A., Kypris, L., Spinar, J., Larsen, M.L., Eldin, H.S., Viigimaa, M., Strandberg, T.E., Ferrieres, J., Agladze, R., Laufs, U., Rallidis, L., Bajnok, L., Gudjonsson, T., Maher, V., Henkin, Y., Gulizia, M.M., Mussagaliyeva, A., Bajraktari, G., Kerimkulova, A., Latkovskis, G., Hamoui, O., Slapikas, R., Visser, L., Dingli, P., Ivanov, V., Boskovic, A., Nazzi, M., Visseren, F., Mitevska, I., Retterstol, K., Jankowski, P., Fontes-Carvalho, R., Gaita, D., Ezhov, M., Foscoli, M., Giga, V., Pella, D., Fras, Z., Isla, L.P. de, Hagstrom, E., Lehmann, R., Abid, L., Ozdogan, O., Mitchenko, O., Patel, R.S., Windecker, S., Aboyans, V., Collet, J.P., Dean, V., Fitzsimons, D., Gale, C.P., Grobbee, D., Halvorsen, S., Hindricks, G., Iung, B., Juni, P., Katus, H.A., Leclercq, C., Lettino, M., Lewis, B.S., Merkely, B., Mueller, C., Petersen, S., Petronio, A.S., Roffi, M., Shlyakhto, E., Simpson, I.A., Sousa-Uva, M., Touyz, R.M., Task Force Members, ESC Natl Cardiac Soc, and ESC Committee Practice Guidelines

Published
2020

3. 2019 ESC Guidelines for themanagement of patients with supraventricular tachycardia

Author

Brugada, J. Katritsis, D.G. Arbelo, E. Arribas, F. Bax, J.J. Blomstrom-Lundqvist, C. Calkins, H. Corrado, D. Deftereos, S.G. Diller, G.-P. Gomez-Doblas, J.J. Gorenek, B. Grace, A. Ho, S.Y. Kaski, J.-C. Kuck, K.-H. Lambiase, P.D. Sacher, F. Sarquella-Brugada, G. Suwalski, P. Zaza, A. De Potter, T. Sticherling, C. Aboyans, V. Basso, C. Bocchiardo, M. Budts, W. Delgado, V. Dobrev, D. Fitzsimons, D. Gevaert, S. Heidbuchel, H. Hindricks, G. Hlivak, P. Kanagaratnam, P. Katus, H. Kautzner, J. Kriebel, T. Lancellotti, P. Landmesser, U. Leclercq, C. Lewis, B. Lopatin, Y. Merkely, B. Paul, T. Pavlović, N. Petersen, S. Petronio, A.S. Potpara, T. Roffi, M. Scherr, D. Shlyakhto, E. Simpson, I.A. Zeppenfeld, K. Windecker, S. Baigent, C. Collet, J.-P. Dean, V. Gale, C.P. Grobbee, D.E. Halvorsen, S. Iung, B. Jüni, P. Lettino, M. Mueller, C. Richter, D.J. Sousa-Uva, M. Touyz, R.M. Amara, W. Grigoryan, S. Podczeck-Schweighofer, A. Chasnoits, A. Vandekerckhove, Y. Sokolovich, S. Traykov, V. Skoric, B. Papasavvas, E. Riahi, S. Kampus, P. Parikka, H. Piot, O. Etsadashvili, K. Stellbrink, C. Manolis, A.S. Csanádi, Z. Gudmundsson, K. Erwin, J. Barsheshet, A. De Ponti, R. Abdrakhmanov, A. Jashari, H. Lunegova, O. Jubele, K. Refaat, M.M. Puodziukynas, A. Groben, L. Grosu, A. Ibtissam, F. Trines, S.A. Poposka, L. Haugaa, K.H. Kowalski, O. Cavaco, D. Dobreanu, D. Mikhaylov, E.N. Zavatta, M. Nebojša, M. Ferreira-Gonzalez, I. Juhlin, T. Reichlin, T. Haouala, H. Akgun, T. Gupta, D. The Task Force for the management of patients with supraventricular tachycardia of the European Society of Cardiology (ESC), Association for European Paediatric Congenital Cardiology (AEPC)

Published
2020

4. Adverse events while awaiting myocardial revascularization: A systematic review and meta-analysis

Author

Head, S.J. (Stuart), B.R. da Costa (Bruno), Beumer, B.R. (Berend), Stefanini, G.G. (Giulio), Alfonso, F. (Fernando), Clemmensen, P. (Peter Michael), Collet, J.P. (Jean Philippe), Cremer, J. (Jochen), Falk, V. (Volkmar), Filippatos, G.S. (Gerasimos), Hamm, C.W. (Christian), Kappetein, A.P. (Arie Pieter), Kastrati, A. (Adnan), Knuuti, J. (Juhani), Kolh, P.H. (Philippe), Landmesser, U. (Ulf), Laufer, G. (Günther), Neumann, F.J., Richter, D.J. (Dimitrios J.), Schauerte, P. (Patrick), Taggart, D.P. (David), Torracca, L. (Lucia), Valgimigli, M. (Marco), Wijns, W. (William), Witkowski, A. (Adam), Windecker, S.W. (Stephan), Jüni, P. (Peter), Sousa-Uva, M. (Miguel), Head, S.J. (Stuart), B.R. da Costa (Bruno), Beumer, B.R. (Berend), Stefanini, G.G. (Giulio), Alfonso, F. (Fernando), Clemmensen, P. (Peter Michael), Collet, J.P. (Jean Philippe), Cremer, J. (Jochen), Falk, V. (Volkmar), Filippatos, G.S. (Gerasimos), Hamm, C.W. (Christian), Kappetein, A.P. (Arie Pieter), Kastrati, A. (Adnan), Knuuti, J. (Juhani), Kolh, P.H. (Philippe), Landmesser, U. (Ulf), Laufer, G. (Günther), Neumann, F.J., Richter, D.J. (Dimitrios J.), Schauerte, P. (Patrick), Taggart, D.P. (David), Torracca, L. (Lucia), Valgimigli, M. (Marco), Wijns, W. (William), Witkowski, A. (Adam), Windecker, S.W. (Stephan), Jüni, P. (Peter), and Sousa-Uva, M. (Miguel)

Abstract

OBJECTIVES: The aim of the current study was to estimate adverse event rates while awaiting myocardial revascularization and review criteria for prioritizing patients. METHODS: A PubMed search was performed on 19 January 2015, to identify English-language, original, observational studies reporting adverse events while awaiting coronary artery bypass grafting (CABG) or percutaneous coronary intervention (PCI). Rates of death, nonfatal myocardial infarction (MI) and emergency revascularization were calculated as occurrence rates per 1000 patient-weeks and pooled using random-effects models. RESULTS: The search yielded 1323 articles, of which 22 were included with 66 410 patients and 607 675 patient-weeks on the wait list. When awaiting CABG, rates per 1000 patient-weeks were 1.1 [95% confidence interval 0.9-1.3] for death, 1.0 [0.6-1.6] for non-fatal MI and 1.8 [0.8-4.1] for emergency revascularization. Subgroup analyses demonstrated consistent outcomes, and sensitivity analyses demonstrated comparable event rates with low heterogeneity. Higher urgency of revascularization was based primarily on angiographic complexity, angina severity, left ventricular dysfunction and symptoms on stress testing, and such patients with a semi-urgent status had a higher risk of death than patients awaiting elective revascularization (risk ratio at least 2.8). Individual studies identified angina severity and left ventricular dysfunction as most important predictors of death when awaiting CABG. Adverse rates per 1000 patient-weeks for patients awaiting PCI were 0.1 [95% confidence interval 0.0-0.4] for death, 0.4 [0.1-1.2] for non-fatal MI and 0.7 [0.4-1.4] for emergency revascularization but were based on only a few old studies. CONCLUSIONS: Rates of death, non-fatal MI and emergency revascularization when awaiting myocardial revascularization are infrequent but higher in specific patients. Countries that not yet have treatment recommendations related to waiting times should consider i

Published
2017
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5. The symbiotic life of Symbiodinium in the open ocean within a new species of calcifying ciliate (Tiarina sp.)

Author

Mordret, S., Romac, S., Henry, N., Colin, S., Carmichael, M., Berney, C., Audic, S., Richter, D.J., Pochon, X., de Vargas, C., Decelle, Johan, Mordret, S., Romac, S., Henry, N., Colin, S., Carmichael, M., Berney, C., Audic, S., Richter, D.J., Pochon, X., de Vargas, C., and Decelle, Johan

Abstract

Symbiotic partnerships between heterotrophic hosts and intracellular microalgae are common in tropical and subtropical oligotrophic waters of benthic and pelagic marine habitats. The iconic example is the photosynthetic dinoflagellate genus Symbiodinium that establishes mutualistic symbioses with a wide diversity of benthic hosts, sustaining highly biodiverse reef ecosystems worldwide. Paradoxically, although various species of photosynthetic dinoflagellates are prevalent eukaryotic symbionts in pelagic waters, Symbiodinium has not yet been reported in symbiosis within oceanic plankton, despite its high propensity for the symbiotic lifestyle. Here we report a new pelagic photosymbiosis between a calcifying ciliate host and the microalga Symbiodinium in surface ocean waters. Confocal and scanning electron microscopy, together with an 18S rDNA-based phylogeny, showed that the host is a new ciliate species closely related to Tiarina fusus (Colepidae). Phylogenetic analyses of the endosymbionts based on the 28S rDNA gene revealed multiple novel closely related Symbiodinium clade A genotypes. A haplotype network using the high-resolution internal transcribed spacer-2 marker showed that these genotypes form eight divergent, biogeographically structured, subclade types that do not seem to associate with any benthic hosts. Ecological analyses using the Tara Oceans metabarcoding data set (V9 region of the 18S rDNA) and contextual oceanographic parameters showed a global distribution of the symbiotic partnership in nutrient-poor surface waters. The discovery of the symbiotic life of Symbiodinium in the open ocean provides new insights into the ecology and evolution of this pivotal microalga and raises new hypotheses about coastal pelagic connectivity.

Published
2015

6. The paradoxical association of common polymorphisms of the renin-angiotensin system genes with risk of myocardial infarction

Author

Andrikopoulos, G.K. Richter, D.J. Needham, E.W. Tzeis, S.E. Zairis, M.N. Gialafos, E.J. Vogiatzi, P.G. Papasteriadis, E.G. Kardaras, F.G. Foussas, S.G. Gialafos, J.E. Stefanadis, C.I. Toutouzas, P.K. Mattu, R.K.

Abstract

The insertion/deletion polymorphism of the angiotensin-converting enzyme (ACE) and the A1166C polymorphism of the angiotensin-II AT1 receptor (AT1R) have been extensively investigated as possible risk factors for myocardial infarction (MI). Genetic association, case-control study, specifically designed to investigate the association of the above-mentioned polymorphisms with risk of MI in a homogeneous, low coronary risk, Caucasian population. The study population consisted of 1603 consecutive patients with acute MI who were recruited from nine clinics, located in three cities, and 699 unrelated adults who were randomly selected from the city catalogues. In univariate analysis, the DD genotype was found to be more prevalent among controls (40.8 vs. 35.2%, P = 0.011). In multivariate analysis adjusted for age, gender, smoking status, diabetes mellitus, hypercholesterolemia, hypertension and family history of coronary artery disease, the presence of the DD genotype was independently and negatively associated with risk of AMI (RR = 0.743, 95% CI = 0.595–0.927, P = 0.008). The CC genotype was not found to be significantly associated with risk of MI, either in univariate (6.2 vs. 6.4%, P = 0.856), or in multivariate analysis adjusted for the same confounders (RR = 0.743, 95% CI = 0.473–1.167, P = 0.197). Contrary to previous reports, in this study the DD genotype of the ACE gene, but not the CC genotype of the AT1R gene, was associated with a lower risk of MI. Our results emphasize the complexity of genotype-phenotype interactions in the pathogenesis of ischaemic heart disease and question the previously hypothesized role of the DD genotype on risk of acute myocardial infarction. © 2004, European Society of Cardiology. All rights reserved.

Published
2004

7. Genome-wide detection and characterization of positive selection in human populations

Author

Sabeti, P.C., Varilly, P., Fry, B., Lohmueller, J., Hostetter, E., Cotsapas, C., Xie, X., Byrne, E.H., McCarroll, S.A., Gaudet, R., Schaffner, S.F., Rotimi, C.N., Adebamowo, C.A., Ajayi, I., Aniagwu, T., Marshall, P.A., Nkwodimmah, C., Royal, C.D.M., Leppert, M.F., Dixon, M., Boudreau, A., Taillon-Miller, P., Peiffer, A., Qiu, R., Kent, A., Kato, K., Niikawa, N., Adewole, I.F., Knoppers, B.M., Foster, M.W., Clayton, E.W., Watkin, J., Xiao, M., Hardenbol, P., Muzny, D., Nazareth, L., Sodergren, E., Weinstock, G.M., Yakub, I., Birren, B.W., Wilson, R.K., Fulton, L.L., Rogers, J., Tsui, L.C., Burton, J., Leal, S.M., Carter, N.P., Clee, C.M., Griffiths, M., Jones, M.C., McLay, K., Plumb, R.W., Ross, M.T., Sims, S.K., Mak, W., Willey, D.L., Chen, Z., Pasternak, S., Han, H., Kang, L., Godbout, M., Wallenburg, J.C., L'Archevêque, P., Bellemare, G., Saeki, K., You, Q.S., Wang, H., An, D., Fu, H., Wheeler, D.A., Li, Q., Wang, Z., Wang, R., Holden, A.L., Brooks, L.D., McEwen, J.E., Tam, P.K.H., Guyer, M.S., Wang, V.O., Peterson, J.L., Shi, M., Willis, T.D., Spiegel, J., Sung, L.M., Zacharia, L.F., Collins, F.S., Kennedy, K., Nakamura, Y., Jamieson, R., Stewart, J., Yu, F., Yang, H., Zeng, C., Gao, Y., Hu, H., Hu, W., Li, C., Lin, W., Kawaguchi, T., Liu, S., Pan, H., Tang, X., Wang, J., Wang, W., Yu, J., Zhang, B., Zhang, Q., Zhao, H., Kitamoto, T., Zhou, J., Gabriel, S.B., Barry, R., Blumenstiel, B., Camargo, A., Defelice, M., Faggart, M., Goyette, M., Gupta, S., Moore, J., Morizono, T., Nguyen, H., Onofrio, R.C., Parkin, M., Roy, J., Stahl, E., Winchester, E., Ziaugra, L., Altshuler, D., Shen, Y., Yao, Z., Lander, E.S., Huang, W., Chu, X., He, Y., Jin, L., Liu, Y., Sun, W., Wang, Y., Nagashima, A., Xiong, X., Xu, L., Waye, M.M.Y., Tsui, S.K.W., Xue, H., Wong, J.T.F., Galver, L.M., Fan, J.B., Gunderson, K., Murray, S.S., Ohnishi, Y., Oliphant, A.R., Chee, M.S., Montpetit, A., Chagnon, F., Ferretti, V., Leboeuf, M., Olivier, J.F., Phillips, M.S., Roumy, S., Sallée, C., Sekine, A., Verner, A., Hudson, T.J., Kwok, P.Y., Cai, D., Koboldt, D.C., Miller, R.D., Pawlikowska, L., Tanaka, T., Tsunoda, T., Deloukas, P., Bird, C.P., Delgado, M., Dermitzakis, E.T., Gwilliam, R., Frazer, K.A., Hunt, S., Morrison, J., Powell, D., Stranger, B.E., Whittaker, P., Bentley, D.R., Daly, M.J., De Bakker, P.I.W., Barrett, J., Chretien, Y.R., Ballinger, D.G., Maller, J., McCarroll, S., Patterson, N., Pe'Er, I., Price, A., Purcell, S., Richter, D.J., Saxena, R., Sham, P.C., Stein, L.D., Cox, D.R., Krishnan, L., Smith, A.V., Tello-Ruiz, M.K., Thorisson, G.A., Chakravarti, A., Chen, P.E., Cutler, D.J., Kashuk, C.S., Lin, S., Abecasis, G.R., Hinds, D.A., Guan, W., Li, Y., Munro, H.M., Qin, Z.S., Thomas, D.J., McVean, G., Auton, A., Bottolo, L., Cardin, N., Eyheramendy, S., Stuve, L.L., Freeman, C., Marchini, J., Myers, S., Spencer, C., Stephens, M., Donnelly, P., Cardon, L.R., Clarke, G., Evans, D.M., Morris, A.P., Gibbs, R.A., Weir, B.S., Johnson, T.A., Mullikin, J.C., Sherry, S.T., Feolo, M., Skol, A., Zhang, H., Matsuda, I., Fukushima, Y., MacEr, D.R., Belmont, J.W., Suda, E., Sabeti, P.C., Varilly, P., Fry, B., Lohmueller, J., Hostetter, E., Cotsapas, C., Xie, X., Byrne, E.H., McCarroll, S.A., Gaudet, R., Schaffner, S.F., Rotimi, C.N., Adebamowo, C.A., Ajayi, I., Aniagwu, T., Marshall, P.A., Nkwodimmah, C., Royal, C.D.M., Leppert, M.F., Dixon, M., Boudreau, A., Taillon-Miller, P., Peiffer, A., Qiu, R., Kent, A., Kato, K., Niikawa, N., Adewole, I.F., Knoppers, B.M., Foster, M.W., Clayton, E.W., Watkin, J., Xiao, M., Hardenbol, P., Muzny, D., Nazareth, L., Sodergren, E., Weinstock, G.M., Yakub, I., Birren, B.W., Wilson, R.K., Fulton, L.L., Rogers, J., Tsui, L.C., Burton, J., Leal, S.M., Carter, N.P., Clee, C.M., Griffiths, M., Jones, M.C., McLay, K., Plumb, R.W., Ross, M.T., Sims, S.K., Mak, W., Willey, D.L., Chen, Z., Pasternak, S., Han, H., Kang, L., Godbout, M., Wallenburg, J.C., L'Archevêque, P., Bellemare, G., Saeki, K., You, Q.S., Wang, H., An, D., Fu, H., Wheeler, D.A., Li, Q., Wang, Z., Wang, R., Holden, A.L., Brooks, L.D., McEwen, J.E., Tam, P.K.H., Guyer, M.S., Wang, V.O., Peterson, J.L., Shi, M., Willis, T.D., Spiegel, J., Sung, L.M., Zacharia, L.F., Collins, F.S., Kennedy, K., Nakamura, Y., Jamieson, R., Stewart, J., Yu, F., Yang, H., Zeng, C., Gao, Y., Hu, H., Hu, W., Li, C., Lin, W., Kawaguchi, T., Liu, S., Pan, H., Tang, X., Wang, J., Wang, W., Yu, J., Zhang, B., Zhang, Q., Zhao, H., Kitamoto, T., Zhou, J., Gabriel, S.B., Barry, R., Blumenstiel, B., Camargo, A., Defelice, M., Faggart, M., Goyette, M., Gupta, S., Moore, J., Morizono, T., Nguyen, H., Onofrio, R.C., Parkin, M., Roy, J., Stahl, E., Winchester, E., Ziaugra, L., Altshuler, D., Shen, Y., Yao, Z., Lander, E.S., Huang, W., Chu, X., He, Y., Jin, L., Liu, Y., Sun, W., Wang, Y., Nagashima, A., Xiong, X., Xu, L., Waye, M.M.Y., Tsui, S.K.W., Xue, H., Wong, J.T.F., Galver, L.M., Fan, J.B., Gunderson, K., Murray, S.S., Ohnishi, Y., Oliphant, A.R., Chee, M.S., Montpetit, A., Chagnon, F., Ferretti, V., Leboeuf, M., Olivier, J.F., Phillips, M.S., Roumy, S., Sallée, C., Sekine, A., Verner, A., Hudson, T.J., Kwok, P.Y., Cai, D., Koboldt, D.C., Miller, R.D., Pawlikowska, L., Tanaka, T., Tsunoda, T., Deloukas, P., Bird, C.P., Delgado, M., Dermitzakis, E.T., Gwilliam, R., Frazer, K.A., Hunt, S., Morrison, J., Powell, D., Stranger, B.E., Whittaker, P., Bentley, D.R., Daly, M.J., De Bakker, P.I.W., Barrett, J., Chretien, Y.R., Ballinger, D.G., Maller, J., McCarroll, S., Patterson, N., Pe'Er, I., Price, A., Purcell, S., Richter, D.J., Saxena, R., Sham, P.C., Stein, L.D., Cox, D.R., Krishnan, L., Smith, A.V., Tello-Ruiz, M.K., Thorisson, G.A., Chakravarti, A., Chen, P.E., Cutler, D.J., Kashuk, C.S., Lin, S., Abecasis, G.R., Hinds, D.A., Guan, W., Li, Y., Munro, H.M., Qin, Z.S., Thomas, D.J., McVean, G., Auton, A., Bottolo, L., Cardin, N., Eyheramendy, S., Stuve, L.L., Freeman, C., Marchini, J., Myers, S., Spencer, C., Stephens, M., Donnelly, P., Cardon, L.R., Clarke, G., Evans, D.M., Morris, A.P., Gibbs, R.A., Weir, B.S., Johnson, T.A., Mullikin, J.C., Sherry, S.T., Feolo, M., Skol, A., Zhang, H., Matsuda, I., Fukushima, Y., MacEr, D.R., Belmont, J.W., and Suda, E.

Abstract

With the advent of dense maps of human genetic variation, it is now possible to detect positive natural selection across the human genome. Here we report an analysis of over 3 million polymorphisms from the International HapMap Project Phase 2 (HapMap2). We used 'long-range haplotype' methods, which were developed to identify alleles segregating in a population that have undergone recent selection, and we also developed new methods that are based on cross-population comparisons to discover alleles that have swept to near-fixation within a population. The analysis reveals more than 300 strong candidate regions. Focusing on the strongest 22 regions, we develop a heuristic for scrutinizing these regions to identify candidate targets of selection. In a complementary analysis, we identify 26 non-synonymous, coding, single nucleotide polymorphisms showing regional evidence of positive selection. Examination of these candidates highlights three cases in which two genes in a common biological process have apparently undergone positive selection in the same population:LARGE and DMD, both related to infection by the Lassa virus, in West Africa;SLC24A5 and SLC45A2, both involved in skin pigmentation, in Europe; and EDAR and EDA2R, both involved in development of hair follicles, in Asia. ©2007 Nature Publishing Group.

Published
2007

13. In-hospital mortality of habitual cigarette smokers after acute myocardial infarction. The ‘smoker’s paradox' in a countrywide study.

Author

Andrikopoulos, G.K, Richter, D.J, Dilaveris, P.E, Pipilis, A, Zaharoulis, A, Gialafos, J.E, Toutouzas, P.K, and Chimonas, E.T

Abstract

Aims Habitual cigarette smokers, paradoxically, present improved short-term prognosis after acute myocardial infarction, a phenomenon often termed ‘smoker’s paradox'. We sought to examine cigarette smokers' post-infarction survival advantage in a countrywide survey of unselected, consecutive patients presenting with acute myocardial infarction.Methods and Results The study population was derived from the registry of the Hellenic study of acute myocardial infarction, which recruited 7433 consecutive patients with acute myocardial infarction from 76, out of a total of 86, hospitals countrywide. Cigarette smokers presented with lower unadjusted mortality rates (7·4% vs 14·5%, P<0·001), were younger, predominantly of male gender and were less likely to suffer from diabetes mellitus and arterial hypertension. When all univariate predictors of poor outcome were included as covariates in multivariate analysis, smoking status was not significantly associated with inhospital mortality (relative risk=1·12, 95% CI=0·86–1·44, P=0·399). The beneficial effect of thrombolytic therapy was independent of the smoking status in both univariate and multivariate analysis.Conclusion Unadjusted mortality rates are significantly lower in smokers, but age accounted for much of their seemingly improved outcome. When a number of additional clinical variables were taken into consideration, no significant influence of habitual smoking on early outcome following acute myocardial infarction was observed. [ABSTRACT FROM PUBLISHER]

Published
2001
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14. The role of carotid atherosclerosis in the distinction between ischaemic and non-ischaemic cardiomyopathy.

Author

Androulakis, A.E, Andrikopoulos, G.K, Richter, D.J, Tentolouris, C.A, Avgeropoulou, C.C, Adamopoulos, D.A, Toutouzas, P.K, Trikas, A.G, Stefanadis, C.I, and Gialafos, J.E

Abstract

Aim Sometimes ischaemic cardiomyopathy is a result of severe coronary artery disease of an occult course, without typical symptoms or evidence of myocardial infarction. This form of presentation is usually indistinguishable from non-ischaemic dilated cardiomyopathy. Carotid bifurcation atherosclerosis and coronary artery disease have been shown to be strongly associated. We prospectively examined the value of extracranial carotid atherosclerosis in the distinction between ischaemic and non-ischaemic aetiology in patients with clinically unexplained cardiomyopathy.Methods and Results Seventy-eight patients with undetermined dilatation and diffuse impairment of the left ventricular contraction were studied within 28 months. They underwent carotid scan and coronary arteriography. Carotid atherosclerosis was found to be very common in ischaemic and rare in non-ischaemic cardiomyopathy. The presence of at least one abnormal carotid finding (intima–media thickness >1mm, plaques, severe carotid stenosis) was 96% sensitive and 89% specific for ischaemic cardiomyopathy.Conclusion Carotid scanning may be a useful screening and decision making tool in patients with cardiomyopathy of indecisive cause. Patients with carotid atherosclerosis are likely to suffer from severe coronary artery disease. Coronary angiography and subsequent myocardial viability studies, when indicated, could be considered early during their evaluation. In contrast, a negative carotid scan predicts non-ischaemic cardiomyopathy. [ABSTRACT FROM PUBLISHER]

Published
2000
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19. 2020 ESC Guidelines for the management of acute coronary syndromes in patients presenting without persistent ST-segment elevation

Author

Collet, Jean-Philippe, Thiele, Holger, Barbato, Emanuele, Barthélémy, Olivier, Bauersachs, Johann, Bhatt, Deepak, Dendale, Paul, Dorobantu, Maria, Edvardsen, Thor, Folliguet, Thierry, Gale, Chris, Gilard, Martine, Jobs, Alexander, Jüni, Peter, Lambrinou, Ekaterini, Lewis, Basil, Mehilli, Julinda, Meliga, Emanuele, Merkely, Béla, Mueller, Christian, Roffi, Marco, Rutten, Frans, Sibbing, Dirk, Siontis, George, Kastrati, Adnan, Mamas, Mamas, Aboyans, Victor, Angiolillo, Dominick, Bueno, Hector, Bugiardini, Raffaele, Byrne, Robert, Castelletti, Silvia, Chieffo, Alaide, Cornelissen, Veronique, Crea, Filippo, Delgado, Victoria, Drexel, Heinz, Gierlotka, Marek, Halvorsen, Sigrun, Haugaa, Kristina Hermann, Jankowska, Ewa, Katus, Hugo, Kinnaird, Tim, Kluin, Jolanda, Kunadian, Vijay, Landmesser, Ulf, Leclercq, Christophe, Lettino, Maddalena, Meinila, Leena, Mylotte, Darren, Ndrepepa, Gjin, Omerovic, Elmir, Pedretti, Roberto, Petersen, Steffen, Petronio, Anna Sonia, Pontone, Gianluca, Popescu, Bogdan, Potpara, Tatjana, Ray, Kausik, Luciano, Flavio, Richter, Dimitrios, Shlyakhto, Evgeny, Simpson, Iain, Sousa-Uva, Miguel, Storey, Robert, Touyz, Rhian, Valgimigli, Marco, VRANCKX, PASCAL, Yeh, Robert, Collet, Jean-Philippe, Thiele, Holger, Barbato, Emanuele, Barthélémy, Olivier, Bauersachs, Johann, Bhatt, Deepak L, Dendale, Paul, Dorobantu, Maria, Edvardsen, Thor, Folliguet, Thierry, Gale, Chris P, Gilard, Martine, Jobs, Alexander, Jüni, Peter, Lambrinou, Ekaterini, Lewis, Basil S, Mehilli, Julinda, Meliga, Emanuele, Merkely, Béla, Mueller, Christian, Roffi, Marco, Rutten, Frans H, Sibbing, Dirk, Siontis, George C M, Unité de Recherche sur les Maladies Cardiovasculaires, du Métabolisme et de la Nutrition = Institute of cardiometabolism and nutrition (ICAN), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-CHU Pitié-Salpêtrière [AP-HP], Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Institut de cardiologie [CHU Pitié-Salpêtrière], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-CHU Pitié-Salpêtrière [AP-HP], Collet J.-P., Thiele H., Barbato E., Bauersachs J., Dendale P., Edvardsen T., Gale C.P., Jobs A., Lambrinou E., Mehilli J., Merkely B., Roffi M., Sibbing D., Kastrati A., Mamas M.A., Aboyans V., Angiolillo D.J., Bueno H., Bugiardini R., Byrne R.A., Castelletti S., Chieffo A., Cornelissen V., Crea F., Delgado V., Drexel H., Gierlotka M., Halvorsen S., Haugaa K.H., Jankowska E.A., Katus H.A., Kinnaird T., Kluin J., Kunadian V., Landmesser U., Leclercq C., Lettino M., Meinila L., Mylotte D., Ndrepepa G., Omerovic E., Pedretti R.F.E., Petersen S.E., Petronio A.S., Pontone G., Popescu B.A., Potpara T., Ray K.K., Luciano F., Richter D.J., Shlyakhto E., Simpson I.A., Sousa-Uva M., Storey R.F., Touyz R.M., Valgimigli M., Vranckx P., Yeh R.W., Barthelemy O., Bhatt D.L., Dorobantu M., Folliguet T., Gilard M., Juni P., Lewis B.S., Meliga E., Mueller C., Rutten F.H., and Siontis G.C.M.

Subjects
unstable angina, Myocardial ischaemia, [SDV]Life Sciences [q-bio], Vascular damage Radboud Institute for Health Sciences [Radboudumc 16], dual antithrombotic therapy, Guideline, heparin, 030204 cardiovascular system & hematology, Platelet inhibition, antiplatelet, 0302 clinical medicine, ST segment, Medicine, dabigatran, Myocardial infarction, guidelines, glycoprotein iib/iiia inhibitors, anticoagulation, Non-ST Elevated Myocardial Infarction, rivaroxaban, ComputingMilieux_MISCELLANEOUS, reproductive and urinary physiology, diabetes, bleedings, bivalirudin, atherothrombosi, Disease Management, angioplasty, Guidelines • acute cardiac care • acute coronary syndrome • angioplasty • anticoagulation • antiplatelet • apixaban • aspirin • atherothrombosis • betablockers • bleedings • bivalirudin • bypass surgery • cangrelor • chest pain unit • clopidogrel • dabigatran • diabetes • dual antithrombotic therapy • early invasive strategy • edoxaban • enoxaparin • European Society of Cardiology • fondaparinux • glycoprotein IIb/ IIIa inhibitors • heparin • high-sensitivity troponin • minoca • myocardial ischaemia • myocardial infarction • nitrates • non-ST-elevation myocardial infarction • platelet inhibition • prasugrel • recommendations • revascularization • rhythm monitoring • rivaroxaban • stent • ticagrelor • triple therapy • unstable angina, enoxaparin, General Medicine, Clopidogrel, 3. Good health, early invasive strategy, myocardial infarction, triple therapy, 030220 oncology & carcinogenesis, High sensitivity troponin, embryonic structures, Cardiology, Platelet aggregation inhibitor, revascularization, biological phenomena, cell phenomena, and immunity, Cardiology and Cardiovascular Medicine, Ticagrelor, medicine.drug, Human, recommendation, Acute coronary syndrome, medicine.medical_specialty, aspirin, glycoprotein IIb/IIIa inhibitor, non-ST-elevation myocardial infarction, apixaban, rhythm monitoring, European Society of Cardiology, ticagrelor, 03 medical and health sciences, nitrate, atherothrombosis, betablockers, Internal medicine, acute cardiac care, minoca, chest pain unit, Diseases of the circulatory (Cardiovascular) system, Humans, In patient, Acute Coronary Syndrome, clopidogrel, Unstable angina, urogenital system, nitrates, business.industry, fondaparinux, betablocker, Arrhythmias, Cardiac, 030229 sport sciences, bleeding, medicine.disease, myocardial ischaemia, platelet inhibition, prasugrel, diabete, Glycoprotein IIb/IIIa inhibitors, RC666-701, bypass surgery, Settore MED/11 - MALATTIE DELL'APPARATO CARDIOVASCOLARE, recommendations, edoxaban, high-sensitivity troponin, stent, business, Platelet Aggregation Inhibitors, cangrelor
Abstract

2020 ESC Guidelines for the management of acute coronary syndromes in patients presenting without persistent ST-segment elevation

Published
2021
Full Text
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20. 2019 ESC Guidelines for the diagnosis and management of acute pulmonary embolism developed in collaboration with the European Respiratory Society (ERS)

Author

Konstantinides, Stavros V., Meyer, Guy, Becattini, Cecilia, Bueno, Hector, Geersing, Geert-Jan, Harjola, Veli-Pekka, Huisman, Menno V., Humbert, Marc, Jennings, Catriona Sian, Jimenez, David, Kucher, Nils, Lang, Irene Marthe, Lankeit, Mareike, Lorusso, Roberto, Mazzolai, Lucia, Meneveau, Nicolas, Ni Ainle, Fionnuala, Prandoni, Paolo, Pruszczyk, Piotr, Righini, Marc, Torbicki, Adam, Van Belle, Eric, Luis Zamorano, Jose, Nazzareno, Galié, J Simon, R Gibbs, Victor, Aboyans, Walter, Ageno, Stefan, Agewall, Ana, G Almeida, Felicita, Andreotti, Emanuele, Barbato, Johann, Bauersachs, Andreas, Baumbach, Farzin, Beygui, Jørn, Carlsen, Marco De Carlo, Marion, Delcroix, Victoria, Delgado, Pilar Escribano Subias, Donna, Fitzsimons, Sean, Gaine, Samuel, Z Goldhaber, Deepa, Gopalan, Gilbert, Habib, Sigrun, Halvorsen, David, Jenkins, Hugo, A Katus, Barbro, Kjellström, Mitja, Lainscak, Patrizio, Lancellotti, Geraldine, Lee, Grégoire Le Gal, Emmanuel, Messas, Joao, Morais, Steffen, E Petersen, Anna Sonia Petronio, Massimo Francesco Piepoli, Susanna, Price, Marco, Roffi, Aldo, Salvi, Olivier, Sanchez, Evgeny, Shlyakhto, Iain, A Simpson, Stefan, Stortecky, Matthias, Thielmann, Anton Vonk Noordegraaf, Cecilia, Becattini, Héctor, Bueno, Geert-Jan, Geersing, Veli-Pekka, Harjola, Menno, V Huisman, Marc, Humbert, Catriona Sian Jennings, David, Jiménez, Nils, Kucher, Irene Marthe Lang, Mareike, Lankeit, Roberto, Lorusso, Lucia, Mazzolai, Nicolas, Meneveau, Fionnuala Ní Áinle, Paolo, Prandoni, Piotr, Pruszczyk, Marc, Righini, Adam, Torbicki, Eric, Vanbelle, José, Luiszamorano, Stephan, Windecker, Colin, Baigent, Jean-Philippe, Collet, Veronica, Dean, Chris, P Gale, Diederick, Grobbee, Gerhard, Hindricks, Bernard, Iung, Peter, Jüni, Ulf, Landmesser, Christophe, Leclercq, Maddalena, Lettino, Basil, S Lewis, Bela, Merkely, Christian, Mueller, Dimitrios, J Richter, Miguel, Sousa-Uva, Rhian, M Touyz, Naima, Hammoudi, Hamlet, Hayrapetyan, Julia, Mascherbauer, Firdovsi, Ibrahimov, Oleg, Polonetsky, Mariya, Tokmakova, Bosko, Skoric, Ioannis, Michaloliakos, Martin, Hutyra, Søren, Mellemkjaer, Mansour, Mostafa, Julia, Reinmets, Pertti, Jääskeläinen, Denis, Angoulvant, George, Giannakoulas, Endre, Zima, Vizza, Carmine Dario, Akhmetzhan, Sugraliyev, Ibadete, Bytyçi, Aija, Maca, Egle, Ereminiene, Steve, Huijnen, Robert, Xuereb, Nadejda, Diaconu, Nebojsa, Bulatovic, Ilyasse, Asfalou, Marijan, Bosevski, Bożena, Sobkowicz, Daniel, Ferreira, Antoniu Octavian Petris, Olga, Moiseeva, Marco, Zavatta, Slobodan, Obradovic, Iveta, Šimkova, Peter, Radsel, Borja, Ibanez, Gerhard, Wikström, Drahomir, Aujesky, Cihangir, Kaymaz, Alexander, Parkhomenko, Joanna, Pepke-Zaba, University of Zurich, Konstantinides, Stavros V, Unité de Recherche sur les Maladies Cardiovasculaires, du Métabolisme et de la Nutrition = Institute of cardiometabolism and nutrition (ICAN), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-CHU Pitié-Salpêtrière [AP-HP], Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Konstantinides S.V., Meyer G., Bueno H., Galie N., Gibbs J.S.R., Ageno W., Agewall S., Almeida A.G., Andreotti F., Barbato E., Baumbach A., Beygui F., Carlsen J., De Carlo M., Delcroix M., Subias P.E., Gaine S., Goldhaber S.Z., Gopalan D., Habib G., Jenkins D., Kjellstrom B., Lainscak M., Lee G., Le Gal G., Messas E., Morais J., Piepoli M.F., Price S., Salvi A., Sanchez O., Stortecky S., Thielmann M., Noordegraaf A.V., Becattini C., Geersing G.-J., Harjola V.-P., Huisman M.V., Humbert M., Jennings C.S., Jimenez D., Kucher N., Lang I., Lankeit M., Lorusso R., Mazzolai L., Meneveau N., Ainle F.N., Prandoni P., Pruszczyk P., Righini M., Torbicki A., Van Belle E., Zamorano J.L., Windecker S., Aboyans V., Baigent C., Collet J.-P., Dean V., Delgado V., Fitzsimons D., Gale C.P., Grobbee D.E., Hindricks G., Iung B., Juni P., Katus H.A., Landmesser U., Leclercq C., Lettino M., Lewis B.S., Merkely B., Mueller C., Petersen S.E., Petronio A.S., Richter D.J., Roffi M., Shlyakhto E., Simpson I.A., Sousa-Uva M., Touyz R.M., Hammoudi N., Hayrapetyan H., Mascherbauer J., Ibrahimov F., Polonetsky O., Lancellotti P., Tokmakova M., Skoric B., Michaloliakos I., Hutyra M., Mellemkjaer S., Mansour M., Reinmets J., Jaaskelainen P., Angoulvant D., Bauersachs J., Giannakoulas G., Zima E., Vizza C.D., Sugraliyev A., Bytyci I., Maca A., Ereminiene E., Huijnen S., Xuereb R., Diaconu N., Bulatovic N., Asfalou I., Bosevski M., Halvorsen S., Sobkowicz B., Ferreira D., Petris A.O., Moiseeva O., Zavatta M., Obradovic S., Simkova I., Radsel P., Ibanez B., Wikstrom G., Aujesky D., Kaymaz C., Parkhomenko A., Pepke-Zaba J., CTC, MUMC+: MA Med Staf Spec CTC (9), and RS: Carim - V04 Surgical intervention

Subjects
ORAL ANTICOAGULANT-THERAPY, diagnosis, [SDV]Life Sciences [q-bio], Medizin, 030204 cardiovascular system & hematology, Embolectomy, Guideline, RECURRENT VENOUS THROMBOEMBOLISM, 0302 clinical medicine, Pregnancy, Daily practice, Diagnosis, Pulmonary medicine, Venous thrombosis, Pulmonary Medicine, Thrombolytic Therapy, DEEP-VEIN THROMBOSIS, Disease management (health), Societies, Medical, ComputingMilieux_MISCELLANEOUS, health care economics and organizations, Risk assessment, ddc:616, RIGHT-VENTRICULAR DYSFUNCTION, Disease Management, Shock, MOLECULAR-WEIGHT HEPARIN, Thrombolysis, humanities, 3. Good health, Pulmonary embolism, Europe, Anticoagulation, Biomarkers, Dyspnoea, Echocardiography, Guidelines, Heart failure, Right ventricle, Treatment, Venous thromboembolism, medicine.vein, Acute Disease, Medical emergency, Cardiology and Cardiovascular Medicine, guidelines, pulmonary embolism, venous thrombosis, shock dyspnoea, heart failure: right ventricle: diagnosis, risk assessment: echocardiography, biomarkers, treatment, anticoagulation, thrombolysis, pregnancy, venous thromboembolism, embolectomy, Diagnosi, education, Cardiology, MEDLINE, Thrombolysi, 610 Medicine & health, Inferior vena cava, 2705 Cardiology and Cardiovascular Medicine, EXTRACORPOREAL MEMBRANE-OXYGENATION, 03 medical and health sciences, Medical, medicine, Humans, RIGHT HEART THROMBI, VENTILATION-PERFUSION SCINTIGRAPHY, Health professionals, business.industry, INFERIOR VENA-CAVA, 10031 Clinic for Angiology, Anticoagulants, 030229 sport sciences, Biomarker, medicine.disease, INHALED NITRIC-OXIDE, Societies, business
Abstract

Guidelines summarize and evaluate available evidence with the aim of assisting health professionals in proposing the best management strategies for an individual patient with a given condition. Guidelines and their recommendations should facilitate decision making of health professionals in their daily practice. However, the final decisions concerning an individual patient must be made by the responsible health professional(s) in consultation with the patient and caregiver as appropriate.

Published
2019

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