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157 results on '"Richmond, Jillian M"'

2. Rational design of a JAK1-selective siRNA inhibitor for the modulation of autoimmunity in the skin

Author

Tang, Qi, Fakih, Hassan H., Zain UI Abideen, Mohammad, Hildebrand, Samuel R., Afshari, Khashayar, Gross, Katherine Y., Sousa, Jacquelyn, Maebius, Allison S., Bartholdy, Christina, Søgaard, Pia Pernille, Jackerott, Malene, Hariharan, Vignesh, Summers, Ashley, Fan, Xueli, Okamura, Ken, Monopoli, Kathryn R., Cooper, David A., Echeverria, Dimas, Bramato, Brianna, McHugh, Nicholas, Furgal, Raymond C., Dresser, Karen, Winter, Sarah J., Biscans, Annabelle, Chuprin, Jane, Haddadi, Nazgol-Sadat, Sherman, Shany, Yıldız-Altay, Ümmügülsüm, Rashighi, Mehdi, Richmond, Jillian M., Bouix-Peter, Claire, Blanchard, Carine, Clauss, Adam, Alterman, Julia F., Khvorova, Anastasia, and Harris, John E.

Published
2023
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5. CXCL9 Links Skin Inflammation and Fibrosis through CXCR3-Dependent Upregulation of Col1a1 in Fibroblasts

Author

Richmond, Jillian M., Patel, Dhrumil, Watanabe, Tomoya, Chen, Henry W., Martyanov, Viktor, Werner, Giffin, Garg, Madhuri, Haddadi, Nazgol-Sadat, Refat, Maggi Ahmed, Mahmoud, Bassel H., Wong, Lance D., Dresser, Karen, Deng, April, Zhu, Jane L., McAlpine, William, Hosler, Gregory A., Feghali-Bostwick, Carol A., Whitfield, Michael L., Harris, John E., Torok, Kathryn S., and Jacobe, Heidi T.

Published
2023
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7. An overview of S100 proteins and their functions in skin homeostasis, interface dermatitis conditions and other skin pathologies.

Author

Abdi, Warda, Romasco, Andrew, Alkurdi, Dany, Santacruz, Elise, Okinedo, Isabel, Zhang, Yuying, Kannan, Shriya, Shakiba, Saeed, and Richmond, Jillian M.

Subjects
LUPUS erythematosus, SKIN proteins, PEPTIDES, LICHEN planus, INFLAMMATION
Abstract

S100 proteins comprise a family of structurally related proteins that are calcium‐sensitive. S100 proteins have been found to play various roles in regulation of cell apoptosis, cell proliferation and differentiation, cell migration and invasion, energy metabolism, calcium homeostasis, protein phosphorylation, anti‐microbial activity and inflammation in a variety of cell types. While the specific function of many S100 proteins remains unknown, some of the S100 proteins serve as disease biomarkers as well as possible therapeutic targets in skin diseases. Interface dermatitis (ID) is a histopathological term that covers many different skin conditions including cutaneous lupus erythematosus, lichen planus, and dermatomyositis. These pathologies share similar histological features, which include basal cell vacuolization and lymphocytic infiltration at the dermal‐epidermal junction. In this review, we summarize how the S100 protein family contributes to both homeostatic and inflammatory processes in the skin. We also highlight the role of S100 proteins in neuronal signalling, describing how this might contribute to neuroimmune interactions in ID and other skin pathologies. Last, we discuss what is known about the S100 family proteins as both biomarkers and potential treatment targets in specific pathologies. [ABSTRACT FROM AUTHOR]

Published
2024
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8. What is Alopecia?

Author

Yildiz-Altay, Ümmügülsüm, primary, Pilson, David S., additional, Richmond, Jillian M., additional, and Senna, Maryanne Makredes, additional

Published
2024
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9. Cathepsin W, T-cell receptor-associated transmembrane adapter 1, lymphotactin and killer cell lectin like receptor K1 are sensitive and specific RNA biomarkers of canine epitheliotropic lymphoma

Author

Olayinka, Jadesola Temitope, primary, Nagarkar, Akanksha, additional, Ma, Diana Junyue, additional, Wong, Neil B., additional, Romasco, Andrew, additional, Piedra-Mora, Cesar, additional, Wrijil, Linda, additional, David, Clement N., additional, Gardner, Heather L., additional, Robinson, Nicholas A., additional, Hughes, Kelly L., additional, Barton, Bruce, additional, London, Cheryl A., additional, Almela, Ramón M., additional, and Richmond, Jillian M., additional

Published
2023
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14. Vitiligo

Author

Richmond, Jillian M., Harris, John E., Gaspari, Anthony A., editor, Tyring, Stephen K., editor, and Kaplan, Daniel H., editor

Published
2017
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19. CXCL9 links skin inflammation and fibrosis via CXCR3-dependent upregulation of collagen 1a1 in fibroblasts

Author

Richmond, Jillian M., primary, Patel, Dhrumil, additional, Watanabe, Tomoya, additional, Chen, Henry W., additional, Martyanov, Viktor, additional, Werner, Giffin, additional, Garg, Madhuri, additional, Haddadi, Nazgol-Sadat, additional, Refat, Maggi Ahmed, additional, Mahmoud, Bassel H., additional, Wong, Lance D., additional, Dresser, Karen, additional, Deng, April, additional, Zhu, Jane L., additional, McAlpine, William, additional, Hosler, Gregory A., additional, Feghali-Bostwick, Carol A., additional, Whitfield, Michael L., additional, Harris, John E., additional, Torok, Kathryn S., additional, and Jacobe, Heidi T., additional

Published
2023
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21. Multiple Sclerosis in Children

Author

Kwong, Danny A., Santoro, Jonathan D., and Richmond, Jillian M.

Subjects
General Medicine
Abstract

Multiple sclerosis (MS) is a disease of the brain that renders people unable to do simple day-to-day activities. The cause of MS remains unknown. Doctors hypothesize that there is a “trigger” that makes the immune systems of people with MS overactive, causing injury to their own brains and nerves. Exposure to certain viruses and vitamin deficiencies can increase a person’s likelihood of developing MS. MS causes relatively similar symptoms in children and adults. However, there are specific differences that make the diagnosis, treatment, and outcomes of MS in children unique. Due to these differences, doctors use a special set of criteria (rules) when diagnosing children. There is no cure for MS, but treatments exist to control symptoms and prevent injury to the brain and nerves.

Published
2022

23. Th2 to Th1 Transition Is Required for Induction of Skin Lesions in an Inducible and Recurrent Murine Model of Cutaneous Lupus–Like Inflammation

Author

Haddadi, Nazgol-Sadat, primary, Mande, Purvi, additional, Brodeur, Tia Y., additional, Hao, Kaiyuan, additional, Ryan, Grace E., additional, Moses, Stephanie, additional, Subramanian, Sharon, additional, Picari, Xhuliana, additional, Afshari, Khashayar, additional, Marshak-Rothstein, Ann, additional, and Richmond, Jillian M., additional

Published
2022
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24. Hungry? How What You Eat Affects Your Skin

Author

Amudzi, Alice A. and Richmond, Jillian M.

Subjects
General Medicine
Abstract

Foods can affect the physical, mental, and emotional aspects of our lives and determine our overall health and productivity. Whether we eat chicken nuggets, apples, or watermelon, food is a vital source of energy that keeps the body’s tissues and organs going during our day-to-day activities. In this article, we examine how various nutrients from foods affect the skin and its ability to protect the body from infections and the elements of the environment. In addition, we briefly discuss a patient who had a wound that was taking a long time to heal, which required surgery to fix. Recommending the right nutrition led to complete healing and cancellation of the surgery.

Published
2022

35. What Is Albinism?

Author

Egbeto, Ista A. and Richmond, Jillian M.

Subjects
General Medicine, sense organs
Abstract

Albinism is a genetic disorder that results in decreased production of a pigment called melanin in the skin, hair, and eyes, resulting in light color or no color. There are several genetic mutations that cause albinism. This condition occurs throughout the world; it affects 1 in 20,000 Americans and is more common in other parts of the world, such as in Zimbabwe, Africa, where 1 in 1,000 people have some form of albinism. Currently there is no cure for albinism, however it can be managed using sunscreen, protective clothing, eyeglasses, magnifying glasses, or eye surgery for eye abnormalities. The impact of this condition on people’s lives can be devastating, so it is important to foster a positive and tolerant environment to promote the emotional and mental well-being of those who are affected.

Published
2021

36. Upcoming treatments for morphea

Author

Wenzel, Dan, primary, Haddadi, Nazgol‐Sadat, additional, Afshari, Khashayar, additional, Richmond, Jillian M., additional, and Rashighi, Mehdi, additional

Published
2021
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47. Type I interferon signaling limits viral vector priming of CD8+ T cells during initiation of vitiligo and melanoma immunotherapy.

Author

Riding, Rebecca L., Richmond, Jillian M., Fukuda, Keitaro, and Harris, John E.

Subjects
*TYPE I interferons, *GENETIC vectors, *VITILIGO, *MELANOMA, *VACCINIA, *CYTOTOXIC T cells
Abstract

Vitiligo is an autoimmune skin disease in which epidermal melanocytes are targeted for destruction by CD8+ T cells specific for melanocyte/melanoma‐shared antigens. IFNγ is the central cytokine driving disease, but the role of type I IFN in vitiligo remains unclear. We investigated the functional role of type I IFN during vitiligo progression using two different mouse models: one induced with a vaccinia virus (VV) vaccine and one induced with dendritic cells to prime autoimmune T cells. Induction of vitiligo by VV in IFNaR‐deficient mice led to the development of severe vitiligo compared with wild‐type (WT) mice and was characterized by a significantly enhanced effector CD8+ T‐cell response. Severe vitiligo in this model was a result of VV persistence, because exacerbation of disease in IFNaR‐deficient mice was not observed when antigen‐pulsed dendritic cells were used to induce vitiligo instead of virus. Treatment of B16F10 melanoma‐inoculated mice with VV vaccine therapy also induced a significantly enhanced anti‐tumor response in IFNaR‐deficient mice compared with WT. These results not only help define the pathways responsible for vitiligo progression but also suggest that blockade of type I IFNs following administration of a VV vaccine may provide increased immunogenicity and efficacy for melanoma immunotherapy. [ABSTRACT FROM AUTHOR]

Published
2021
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