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214 results on '"Richmond, Jillian"'

1. Rational design of a JAK1-selective siRNA inhibitor for the modulation of autoimmunity in the skin

Author

Tang, Qi, Fakih, Hassan H., Zain UI Abideen, Mohammad, Hildebrand, Samuel R., Afshari, Khashayar, Gross, Katherine Y., Sousa, Jacquelyn, Maebius, Allison S., Bartholdy, Christina, Søgaard, Pia Pernille, Jackerott, Malene, Hariharan, Vignesh, Summers, Ashley, Fan, Xueli, Okamura, Ken, Monopoli, Kathryn R., Cooper, David A., Echeverria, Dimas, Bramato, Brianna, McHugh, Nicholas, Furgal, Raymond C., Dresser, Karen, Winter, Sarah J., Biscans, Annabelle, Chuprin, Jane, Haddadi, Nazgol-Sadat, Sherman, Shany, Yıldız-Altay, Ümmügülsüm, Rashighi, Mehdi, Richmond, Jillian M., Bouix-Peter, Claire, Blanchard, Carine, Clauss, Adam, Alterman, Julia F., Khvorova, Anastasia, and Harris, John E.

Published
2023
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4. CXCL9 Links Skin Inflammation and Fibrosis through CXCR3-Dependent Upregulation of Col1a1 in Fibroblasts

Author

Richmond, Jillian M., Patel, Dhrumil, Watanabe, Tomoya, Chen, Henry W., Martyanov, Viktor, Werner, Giffin, Garg, Madhuri, Haddadi, Nazgol-Sadat, Refat, Maggi Ahmed, Mahmoud, Bassel H., Wong, Lance D., Dresser, Karen, Deng, April, Zhu, Jane L., McAlpine, William, Hosler, Gregory A., Feghali-Bostwick, Carol A., Whitfield, Michael L., Harris, John E., Torok, Kathryn S., and Jacobe, Heidi T.

Published
2023
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7. An overview of S100 proteins and their functions in skin homeostasis, interface dermatitis conditions and other skin pathologies.

Author

Abdi, Warda, Romasco, Andrew, Alkurdi, Dany, Santacruz, Elise, Okinedo, Isabel, Zhang, Yuying, Kannan, Shriya, Shakiba, Saeed, and Richmond, Jillian M.

Subjects
LUPUS erythematosus, SKIN proteins, PEPTIDES, LICHEN planus, INFLAMMATION
Abstract

S100 proteins comprise a family of structurally related proteins that are calcium‐sensitive. S100 proteins have been found to play various roles in regulation of cell apoptosis, cell proliferation and differentiation, cell migration and invasion, energy metabolism, calcium homeostasis, protein phosphorylation, anti‐microbial activity and inflammation in a variety of cell types. While the specific function of many S100 proteins remains unknown, some of the S100 proteins serve as disease biomarkers as well as possible therapeutic targets in skin diseases. Interface dermatitis (ID) is a histopathological term that covers many different skin conditions including cutaneous lupus erythematosus, lichen planus, and dermatomyositis. These pathologies share similar histological features, which include basal cell vacuolization and lymphocytic infiltration at the dermal‐epidermal junction. In this review, we summarize how the S100 protein family contributes to both homeostatic and inflammatory processes in the skin. We also highlight the role of S100 proteins in neuronal signalling, describing how this might contribute to neuroimmune interactions in ID and other skin pathologies. Last, we discuss what is known about the S100 family proteins as both biomarkers and potential treatment targets in specific pathologies. [ABSTRACT FROM AUTHOR]

Published
2024
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8. What is Alopecia?

Author

Yildiz-Altay, Ümmügülsüm, primary, Pilson, David S., additional, Richmond, Jillian M., additional, and Senna, Maryanne Makredes, additional

Published
2024
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9. Spatial characterization of interface dermatitis in cutaneous lupus reveals novel chemokine ligand-receptor pairs that drive disease

Author

Shakiba, Saeed, primary, Haddadi, Nazgol-Sadat, additional, Afshari, Khashayar, additional, Lubov, Janet E., additional, Raef, Haya S., additional, Li, Robert, additional, Yildiz-Altay, Ümmügülsüm, additional, Daga, Mridushi, additional, Refat, Maggi Ahmed, additional, Kim, Evangeline, additional, Galindo de Laflin, Johanna, additional, Akabane, Andressa, additional, Sherman, Shany, additional, MacDonald, Elizabeth, additional, Strassner, James P., additional, Zhang, Liang, additional, Leon, Michael, additional, Baer, Christina E., additional, Dresser, Karen, additional, Liang, Yan, additional, Whitley, James B, additional, Skopelja-Gardner, Sladjana, additional, Harris, John E, additional, Deng, April, additional, Vesely, Matthew D., additional, Rashighi, Mehdi, additional, and Richmond, Jillian, additional

Published
2024
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11. Cathepsin W, T-cell receptor-associated transmembrane adapter 1, lymphotactin and killer cell lectin like receptor K1 are sensitive and specific RNA biomarkers of canine epitheliotropic lymphoma

Author

Olayinka, Jadesola Temitope, primary, Nagarkar, Akanksha, additional, Ma, Diana Junyue, additional, Wong, Neil B., additional, Romasco, Andrew, additional, Piedra-Mora, Cesar, additional, Wrijil, Linda, additional, David, Clement N., additional, Gardner, Heather L., additional, Robinson, Nicholas A., additional, Hughes, Kelly L., additional, Barton, Bruce, additional, London, Cheryl A., additional, Almela, Ramón M., additional, and Richmond, Jillian M., additional

Published
2023
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15. Vitiligo

Author

Richmond, Jillian M., Harris, John E., Gaspari, Anthony A., editor, Tyring, Stephen K., editor, and Kaplan, Daniel H., editor

Published
2017
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16. Time is on my side ... or is it? : do our subjective experiences of time perspective and representations of time influence emotions and goal achievement?

Author

Richmond, Jillian, Wilson, Janet, Cherryman, Julie, and Zinken, Joerg

Subjects
115, Psychology
Abstract

Time is objectively measurable, but is subjectively understood within our own time perspective (Zimbardo & Boyd, 1999) and representations of time (Margolies & Crawford, 2008; McGlone & Harding, 1998). The present thesis is in two parts. Part 1 explored how our perceptions and representations of time may influence our emotions. Study 1 sought to validate a measure of two time representations (ego-moving and time-moving) and found that people think about time in a metaphor-consistent manner across clock, calendar, and spatial questions (N=94). Study 2 (N=128) found that those choosing an ego-moving representation were more likely to see themselves approaching events, reported higher levels of personal agency and scored higher in the Future time perspective. Those who choose a time-moving representation saw the event as approaching them, had significantly lower scores on personal agency and scored highly on Present Fatalism. Study 3 (N=199) found that those who reported an ego-moving representation were significantly happier, whereas those reporting a time-moving representation were significantly more anxious and depressed. Study 4 (N=232) found that when happiness is induced, participants report significantly more ego-moving representations, whereas when anxiety or sadness are induced, participants report significantly more time-moving representations. Study 5 (N=106) found that when ego-moving representations were induced, participants reported significantly higher happiness scores, whereas when time-moving was induced participants report significantly higher anxiety and sadness/depression. Part 2 explored one aspect of ego-moving representations of time, that of goal-getting and perceptions of time morem closely. In study 6 (N=139), time perspective was explored in relation to non-achievement of goals. Findings suggest those high in Present Fatalism procrastinate significantly more frequently and often only form the intention towards achieving their goals, and were significantly more upset at past failures. Fatalists also tended not to use cognitive reappraisal strategies to enable them to think differently about how to achieve their goal in future attempts. Those high in the Future time perspective were less likely to procrastinate, less upset at non-attainment of goals, and did tend to use cognitive reappraisal. Study 7 (N=162) examined time perspective, self-efficacy, and goal achievement. For those who achieved their goal within 7 days, the Past Positive and Future time perspectives positively predicted self-efficacy, whereas Present Fatalism negatively predicted self-efficacy. Finally, study 8 (N=76) sought to determine whether focussing on different time perspectives were of help in achieving goals. Results revealed that by focusing on what we have achieved in the past and thinking about managing our future time in the same way we think about our present time may help us to achieve our goals by increasing self-efficacy.

Published
2012

23. CXCL9 links skin inflammation and fibrosis via CXCR3-dependent upregulation of collagen 1a1 in fibroblasts

Author

Richmond, Jillian M., primary, Patel, Dhrumil, additional, Watanabe, Tomoya, additional, Chen, Henry W., additional, Martyanov, Viktor, additional, Werner, Giffin, additional, Garg, Madhuri, additional, Haddadi, Nazgol-Sadat, additional, Refat, Maggi Ahmed, additional, Mahmoud, Bassel H., additional, Wong, Lance D., additional, Dresser, Karen, additional, Deng, April, additional, Zhu, Jane L., additional, McAlpine, William, additional, Hosler, Gregory A., additional, Feghali-Bostwick, Carol A., additional, Whitfield, Michael L., additional, Harris, John E., additional, Torok, Kathryn S., additional, and Jacobe, Heidi T., additional

Published
2023
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28. Hungry? How What You Eat Affects Your Skin

Author

Amudzi, Alice A. and Richmond, Jillian M.

Subjects
General Medicine
Abstract

Foods can affect the physical, mental, and emotional aspects of our lives and determine our overall health and productivity. Whether we eat chicken nuggets, apples, or watermelon, food is a vital source of energy that keeps the body’s tissues and organs going during our day-to-day activities. In this article, we examine how various nutrients from foods affect the skin and its ability to protect the body from infections and the elements of the environment. In addition, we briefly discuss a patient who had a wound that was taking a long time to heal, which required surgery to fix. Recommending the right nutrition led to complete healing and cancellation of the surgery.

Published
2022

29. Th2 to Th1 Transition Is Required for Induction of Skin Lesions in an Inducible and Recurrent Murine Model of Cutaneous Lupus–Like Inflammation

Author

Haddadi, Nazgol-Sadat, primary, Mande, Purvi, additional, Brodeur, Tia Y., additional, Hao, Kaiyuan, additional, Ryan, Grace E., additional, Moses, Stephanie, additional, Subramanian, Sharon, additional, Picari, Xhuliana, additional, Afshari, Khashayar, additional, Marshak-Rothstein, Ann, additional, and Richmond, Jillian M., additional

Published
2022
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38. What Is Albinism?

Author

Egbeto, Ista A. and Richmond, Jillian M.

Subjects
General Medicine, sense organs
Abstract

Albinism is a genetic disorder that results in decreased production of a pigment called melanin in the skin, hair, and eyes, resulting in light color or no color. There are several genetic mutations that cause albinism. This condition occurs throughout the world; it affects 1 in 20,000 Americans and is more common in other parts of the world, such as in Zimbabwe, Africa, where 1 in 1,000 people have some form of albinism. Currently there is no cure for albinism, however it can be managed using sunscreen, protective clothing, eyeglasses, magnifying glasses, or eye surgery for eye abnormalities. The impact of this condition on people’s lives can be devastating, so it is important to foster a positive and tolerant environment to promote the emotional and mental well-being of those who are affected.

Published
2021

40. Upcoming treatments for morphea

Author

Wenzel, Dan, primary, Haddadi, Nazgol‐Sadat, additional, Afshari, Khashayar, additional, Richmond, Jillian M., additional, and Rashighi, Mehdi, additional

Published
2021
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48. Loss of nuclear pro-1L-16 facilitates cell cycle progression in human cutaneous T cell lymphoma

Author

Curiel-Lewandrowski, Clara, Yamasaki, Hisato, Si, Chuan Ping, Jin, Xiaoyi, Zhang, Yujun, Richmond, Jillian, Tuzova, Marina, Wilson, Kevin, Sullivan, Beth, Jones, David, Ryzhenko, Nataliya, Little, Frederick, Kupper, Thomas S., Center, David M., and Cruikshank, William W.

Subjects
T cells -- Growth -- Genetic aspects, Cell cycle -- Genetic aspects, Lymphomas -- Diagnosis -- Care and treatment, Interleukins -- Properties, Company growth, Health care industry
Abstract

Cutaneous T cell lymphomas (CTCLs) represent a heterogeneous group of non-Hodgkin lymphomas that affect the skin. The pathogenesis of these conditions is poorly understood. For example, the signaling mechanisms contributing to the dysregulated growth of the neoplastic T cells are not well defined. Here, we demonstrate that loss of nuclear localization of pro-IL-16 facilitates CTCL cell proliferation by causing a decrease in expression of the cyclin dependent-kinase inhibitor p27Kip1. The decrease in p27Kip1 expression was directly attributable to an increase in expression of S-phase kinase-associated protein 2 (Skp2). Regulation of Skp2 is in part attributed to the nuclear presence of the scaffold protein pro-IL-16. T cells isolated from 11 patients with advanced CTCL, but not those from healthy controls or patients with T cell acute lymphocytic leukemia (T-ALL), demonstrated reduction in nuclear pro-IL-16 levels. Sequence analysis identified the presence of mutations in the 5'end of the PDZ1 region of pro-IL-16, a domain required for association of pro-IL-16 with the nuclear chaperone HSC70 (also known as HSPA8). HSC70 knockdown led to loss of nuclear translocation by pro-IL-16 and subsequent increases in Skp2 levels and decreases in p27Kip1 levels, which ultimately enhanced T cell proliferation. Thus, our data indicate that advanced CTCL cell growth is facilitated, at least in part, by mutations in the scaffold protein pro-IL-16, which directly regulates Skp2 synthesis., Introduction Primary cutaneous T cell lymphomas (CTCLs) represent a heterogeneous group of extranodal non-Hodgkin lymphomas whose pathogenesis is poorly understood. The most frequent forms of CTCL are mycosis fungoides and [...]

Published
2011
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