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3. Optimising surgical anastomosis in ileocolic resection for Crohn’s disease with respect to recurrence and functionality: two international parallel randomized controlled trials comparing handsewn (END-to-end or Kono-S) to stapled anastomosis (HAND2END and the End2End STUDIES)

Author

Haanappel, Anouck E. G., Bellato, Vittoria, Buskens, Christianne J., Armuzzi, Alessandro, van der Bilt, Jarmila D. W., de Boer, Nanne K. H., Danese, Silvio, van der Does de Willebois, Eline M. L., Duijvestein, Marjolijn, van der Horst, Daniëlle, Pellino, Gianluca, Richir, Milan C., Selvaggi, Francesco, Spinelli, Antonino, Vignali, Andrea, Rosati, Riccardo, and Bemelman, Willem A.

Published
2024
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4. The impact of a summative national prescribing assessment and curriculum type on the development of the prescribing competence of junior doctors

Author

Donker, Erik M., Osmani, Hayaudin, Brinkman, David J., van Rosse, Floor, Janssen, Ben, Knol, Wilma, Dumont, Glenn, Jorens, Philippe G., Dupont, Alain, Christiaens, Thierry, van Smeden, Jeroen, de Waard-Siebinga, Itte, Peeters, Laura E. J., Goorden, Ronald, Hessel, Marleen, Lissenberg-Witte, Birgit I., Richir, Milan C., van Agtmael, Michiel A., Kramers, Cornelis, and Tichelaar, Jelle

Published
2023
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6. Correction: Limited wedge resection for T1 colon cancer (LIMERIC-II trial) – rationale and study protocol of a prospective multicenter clinical trial

Author

Hanevelt, Julia, Huisman, Jelle F., Leicher, Laura W., Lacle, Miangela M., Richir, Milan C., Didden, Paul, Geesing, Joost M. J., Smakman, Niels, Sive Droste, Jochim S. Terhaar, ter Borg, Frank, Talsma, A. Koen, Schrauwen, Ruud W. M., van Wely, Bob J., Schot, Ingrid, Vermaas, Maarten, Bos, Philip, Sietses, Colin, Hazen, Wouter L., Wasowicz, Dareczka K., Ploeg, David E., Ramsoekh, Dewkoemar, Tuynman, Jurriaan B., Alderlieste, Yasser A., Renger, Rutger-Jan, Schreuder, Ramon-Michel, Bloemen, Johanne G., van Lijnschoten, Ineke, Consten, Esther C. J., Sikkenk, Daan J., Schwartz, Matthijs P., Vos, Annelotte, Burger, Jordy P. W., Spanier, Bernhard W. M., Knijn, Nikki, Cappel, Wouter H. de Vos Tot Nederveen, Moons, Leon M. G., and van Westreenen, Henderik L.

Published
2023
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7. Limited wedge resection for T1 colon cancer (LIMERIC-II trial) – rationale and study protocol of a prospective multicenter clinical trial

Author

Hanevelt, Julia, Huisman, Jelle F., Leicher, Laura W., Lacle, Miangela M., Richir, Milan C., Didden, Paul, Geesing, Joost M. J., Smakman, Niels, Droste, Jochim S. Terhaar Sive, ter Borg, Frank, Talsma, A. Koen, Schrauwen, Ruud W. M., van Wely, Bob J., Schot, Ingrid, Vermaas, Maarten, Bos, Philip, Sietses, Colin, Hazen, Wouter L., Wasowicz, Dareczka K., Ploeg, David E., Ramsoekh, Dewkoemar, Tuynman, Jurriaan B., Alderlieste, Yasser A., Renger, Rutger-Jan, Schreuder, Ramon-Michel, Bloemen, Johanne G., van Lijnschoten, Ineke, Consten, Esther C. J., Sikkenk, Daan J., Schwartz, Matthijs P., Vos, Annelotte, Burger, Jordy P. W., Spanier, Bernhard W. M., Knijn, Nikki, de Vos Tot Nederveen Cappel, Wouter H., Moons, Leon M. G., and van Westreenen, Henderik L.

Published
2023
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17. Perioperative SARS-CoV-2 infections increase mortality, pulmonary complications, and thromboembolic events: A Dutch, multicenter, matched-cohort clinical study

Author

Boerma, Djamilla, Gerritsen, Sarah L., van der Meij, Wout, van Petersen, André S., Stevens, Charles T., van Sambeek, Marc, Hölscher, Marleen, Pronk, Apollo, Bakker, Wouter J., Vriens, Patrick Whe, Houwen, Thymen, Wegdam, Johannes A., de Vries Reilingh, Tammo S., Schipper, Ellis, Teeuwen, Pascal HE., van Ginhoven, Tessa M., Viëtor, Charlotte, van der Oest, Mark JW., Gans, Sarah, van Duijvendijk, Peter, Herklots, Tanneke, de Hoop, Tom, de Graaff, Michelle, Sloothaak, Didi, Bolster - van Eenennaam, Marieke, Baaij, Jedidja, Vermaas, Maarten, Voigt, Kelly R., Patijn, Gijs A., Bransma, Amarins TA., Leclercq, Wouter KG., Sijmons, Julie ML., Uittenbogaart, Martine, Verheijen, Paul M., Burghgraef, Thijs A., Emous, Marloes, Poelstra, Ralph, Teunissen, Manon, Frima, Herman, Bachiri, Said, Groen, Lennaert CB., de Reuver, Philip R., Thunissen, Floris M., Vermeulen, Britt AM., Groen, Anna, van Eekeren, Ramon RJP., Spillenaar Bilgen, Ernst J., Harlaar, Niels J., Jonker, Fredrik HW., van der Burg, Sjirk W., Posma-Bouman, Lisanne AE., Oosterling, Steven J., Franken, Josephine, Nellensteijn, David R., Bensi, Elena Argia Bianca, van den Broek, Wim, Hendriks, Eduard R., van Geloven, Anna AW., Kruijff, Schelto, de Vries, Jean-Paul P.M., Steinkamp, Pieter J., Jonker, Pascal KC., van der Plas, Willemijn Y., Bierman, Wouter FW., Struys, Michel MRF., Janssen, Yester F., van Dam, Gooitzen M., IJpma, Frank FA., van der Riet, Claire, Feitsma, Eline, Ma, Kirsten, Kleiss, Simone, Richir, Milan C., Vriens, Menno R., Filipe, Mando D., den Boer, Frank C., Dekker, Nicole AM., Verhagen, Tim, ter Brugge, Floor, Lagae, Emmanuel AGL., Boerma, Evert-Jan G., Schweitzer, Donald, Keulen, Mark HF., Ketting, Shirley, Jonker, Pascal K.C., Thunnissen, Floris, Bierman, Wouter F.W., and Struys, Michel M.R.F.

Published
2021
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18. The European List of Key Medicines for Medical Education: A Modified Delphi Study

Author

Donker, Erik M., Timpone, Pietro Spitaleri, Brinkman, David J., Richir, Milan C., Papaioannidou, Paraskevi, Likic, Robert, Sanz, Emilio J., Christiaens, Thierry, Costa, Joao N., De Ponti, Fabrizio, Gatti, Milo, Böttiger, Ylva, Kramers, Cornelis, Pandit, Rahul, van Agtmael, Michiel A., Tichelaar, Jelle, Donker, Erik M., Timpone, Pietro Spitaleri, Brinkman, David J., Richir, Milan C., Papaioannidou, Paraskevi, Likic, Robert, Sanz, Emilio J., Christiaens, Thierry, Costa, Joao N., De Ponti, Fabrizio, Gatti, Milo, Böttiger, Ylva, Kramers, Cornelis, Pandit, Rahul, van Agtmael, Michiel A., and Tichelaar, Jelle

Abstract

Rational prescribing is essential for the quality of health care. However, many final-year medical students and junior doctors lack prescribing competence to perform this task. The availability of a list of medicines that a junior doctor working in Europe should be able to independently prescribe safely and effectively without supervision could support and harmonize teaching and training in clinical pharmacology and therapeutics (CPT) in Europe. Therefore, our aim was to achieve consensus on such a list of medicines that are widely accessible in Europe. For this, we used a modified Delphi study method consisting of three parts. In part one, we created an initial list based on a literature search. In part two, a group of 64 coordinators in CPT education, selected via the Network of Teachers in Pharmacotherapy of the European Association for Clinical Pharmacology and Therapeutics, evaluated the accessibility of each medicine in his or her country, and provided a diverse group of experts willing to participate in the Delphi part. In part three, 463 experts from 24 European countries were invited to participate in a 2-round Delphi study. In total, 187 experts (40%) from 24 countries completed both rounds and evaluated 416 medicines, 98 of which were included in the final list. The top three Anatomical Therapeutic Chemical code groups were (1) cardiovascular system (n = 23), (2) anti-infective (n = 21), and (3) musculoskeletal system (n = 11). This European List of Key Medicines for Medical Education could be a starting point for country-specific lists and could be used for the training and assessment of CPT., Funding Agencies|Erasmus + [2019- 1-NL01- KA203-060492]

Published
2024
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19. Postoperative outcomes of surgical delay in inflammatory bowel disease patients: a multicenter cohort study

Author

MS CGO, Cancer, Heelkunde Opleiding, MS MDL 1, Infection & Immunity, de Bock, Ellen, Herman, Eline S, Meij, Vincent, Burghgraef, Thijs A, Oldenburg, Bas, Verheijen, Paul M, Pronk, Apollo, Filipe, Mando D, Vriens, Menno R, Richir, Milan C, MS CGO, Cancer, Heelkunde Opleiding, MS MDL 1, Infection & Immunity, de Bock, Ellen, Herman, Eline S, Meij, Vincent, Burghgraef, Thijs A, Oldenburg, Bas, Verheijen, Paul M, Pronk, Apollo, Filipe, Mando D, Vriens, Menno R, and Richir, Milan C

Published
2024

20. Predictors of postoperative lumpectomy size in breast-conserving surgery in breast cancer patients: a retrospective cohort study

Author

MS CGO, Cancer, Zorgeenheid Plastische Chirurgie Medisch, Other research (not in main researchprogram), Makineli, Seher, Strijbis, Rogier, Tsehaie, Jonathan, Schellekens, Pascal P A, Moman, Maaike, Veenendaal, Liesbeth, Ferdinandus, P, Witkamp, Arjen J, Richir, Milan, Maarse, Wies, MS CGO, Cancer, Zorgeenheid Plastische Chirurgie Medisch, Other research (not in main researchprogram), Makineli, Seher, Strijbis, Rogier, Tsehaie, Jonathan, Schellekens, Pascal P A, Moman, Maaike, Veenendaal, Liesbeth, Ferdinandus, P, Witkamp, Arjen J, Richir, Milan, and Maarse, Wies

Published
2024

21. Optimising surgical anastomosis in ileocolic resection for Crohn's disease with respect to recurrence and functionality: two international parallel randomized controlled trials comparing handsewn (END-to-end or Kono-S) to stapled anastomosis (HAND2END and the End2End STUDIES)

Author

MS CGO, Cancer, Haanappel, Anouck E G, Bellato, Vittoria, Buskens, Christianne J, Armuzzi, Alessandro, van der Bilt, Jarmila D W, de Boer, Nanne K H, Danese, Silvio, van der Does de Willebois, Eline M L, Duijvestein, Marjolijn, van der Horst, Daniëlle, Pellino, Gianluca, Richir, Milan C, Selvaggi, Francesco, Spinelli, Antonino, Vignali, Andrea, Rosati, Riccardo, Bemelman, Willem A, MS CGO, Cancer, Haanappel, Anouck E G, Bellato, Vittoria, Buskens, Christianne J, Armuzzi, Alessandro, van der Bilt, Jarmila D W, de Boer, Nanne K H, Danese, Silvio, van der Does de Willebois, Eline M L, Duijvestein, Marjolijn, van der Horst, Daniëlle, Pellino, Gianluca, Richir, Milan C, Selvaggi, Francesco, Spinelli, Antonino, Vignali, Andrea, Rosati, Riccardo, and Bemelman, Willem A

Published
2024

26. Using artificial intelligence to create diverse and inclusive medical case vignettes for education.

Author

Bakkum, Michiel J., Hartjes, Mariëlle G., Piët, Joost D., Donker, Erik M., Likic, Robert, Sanz, Emilio, de Ponti, Fabrizio, Verdonk, Petra, Richir, Milan C., van Agtmael, Michiel A., and Tichelaar, Jelle

Subjects
ARTIFICIAL intelligence, COMPUTER literacy, VIGNETTES, CHATGPT, STUDENT attitudes
Abstract

Aims: Medical case vignettes play a crucial role in medical education, yet they often fail to authentically represent diverse patients. Moreover, these vignettes tend to oversimplify the complex relationship between patient characteristics and medical conditions, leading to biased and potentially harmful perspectives among students. Displaying aspects of patient diversity, such as ethnicity, in written cases proves challenging. Additionally, creating these cases places a significant burden on teachers in terms of labour and time. Our objective is to explore the potential of artificial intelligence (AI)‐assisted computer‐generated clinical cases to expedite case creation and enhance diversity, along with AI‐generated patient photographs for more lifelike portrayal. Methods: In this study, we employed ChatGPT (OpenAI, GPT 3.5) to develop diverse and inclusive medical case vignettes. We evaluated various approaches and identified a set of eight consecutive prompts that can be readily customized to accommodate local contexts and specific assignments. To enhance visual representation, we utilized Adobe Firefly beta for image generation. Results: Using the described prompts, we consistently generated cases for various assignments, producing sets of 30 cases at a time. We ensured the inclusion of mandatory checks and formatting, completing the process within approximately 60 min per set. Conclusions: Our approach significantly accelerated case creation and improved diversity, although prioritizing maximum diversity compromised representativeness to some extent. While the optimized prompts are easily reusable, the process itself demands computer skills not all educators possess. To address this, we aim to share all created patients as open educational resources, empowering educators to create cases independently. [ABSTRACT FROM AUTHOR]

Published
2024
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28. Optimising surgical anastomosis in ileocolic resection for Crohn's disease with respect to recurrence and functionality: Two international parallel randomized controlled trials comparing handsewn (end-to-end or Kono-S) to stapled anastomosis (HAND2END and the End2End STUDIES).

Author

Haanappel, Anouck, primary, Bellato, Vittoria, additional, Buskens, Christianne J, additional, Armuzzi, Alessandro, additional, Bilt, Jarmilla D W van der, additional, de Boer, Nanne K H, additional, Danese, Silvio, additional, de Willeboi, Eline M L van der Does, additional, Duijvestein, Marjolijn Duijveste, additional, Horst, Danielle van der, additional, Pellino, Gianluca, additional, Richir, Milan C, additional, Selvaggi, Francesco, additional, Spinelli, Antonino, additional, Vignali, Andrea, additional, Rosati, Riccardo, additional, and Bemelman, Willem A, additional

Published
2023
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29. Breast carcinoma detection in ex vivo fresh human breast surgical specimens using a fast slide-free confocal microscopy scanner: HIBISCUSS project

Author

Conversano, Angelica, primary, Abbaci, Muriel, additional, van Diest, Paul, additional, Roulot, Aurélie, additional, Falco, Giuseppe, additional, Ferchiou, Malek, additional, Coiro, Saverio, additional, Richir, Milan, additional, Genolet, Pierre-Michel, additional, Clement, Carine, additional, Casiraghi, Odile, additional, Lahkdar, Aicha Ben, additional, Labaied, Nizard, additional, Ragazzi, Moira, additional, and Mathieu, Marie-Christine, additional

Published
2023
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30. The augmented value of using clinical notes in semi-automated surveillance of deep surgical site infections after colorectal surgery

Author

Verberk, Janneke D. M., van der Werff, Suzanne D., Weegar, Rebecka, Henriksson, Aron, Richir, Milan C., Buchli, Christian, van Mourik, Maaike S. M., Naucler, Pontus, Verberk, Janneke D. M., van der Werff, Suzanne D., Weegar, Rebecka, Henriksson, Aron, Richir, Milan C., Buchli, Christian, van Mourik, Maaike S. M., and Naucler, Pontus

Abstract

BackgroundIn patients who underwent colorectal surgery, an existing semi-automated surveillance algorithm based on structured data achieves high sensitivity in detecting deep surgical site infections (SSI), however, generates a significant number of false positives. The inclusion of unstructured, clinical narratives to the algorithm may decrease the number of patients requiring manual chart review. The aim of this study was to investigate the performance of this semi-automated surveillance algorithm augmented with a natural language processing (NLP) component to improve positive predictive value (PPV) and thus workload reduction (WR).MethodsRetrospective, observational cohort study in patients who underwent colorectal surgery from January 1, 2015, through September 30, 2020. NLP was used to detect keyword counts in clinical notes. Several NLP-algorithms were developed with different count input types and classifiers, and added as component to the original semi-automated algorithm. Traditional manual surveillance was compared with the NLP-augmented surveillance algorithms and sensitivity, specificity, PPV and WR were calculated.ResultsFrom the NLP-augmented models, the decision tree models with discretized counts or binary counts had the best performance (sensitivity 95.1% (95%CI 83.5-99.4%), WR 60.9%) and improved PPV and WR by only 2.6% and 3.6%, respectively, compared to the original algorithm.ConclusionsThe addition of an NLP component to the existing algorithm had modest effect on WR (decrease of 1.4-12.5%), at the cost of sensitivity. For future implementation it will be a trade-off between optimal case-finding techniques versus practical considerations such as acceptability and availability of resources.

Published
2023
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31. Educational value of international and intercultural differences in prescribing:the international and interprofessional student-run clinic project

Author

Bakkum, Michiel J., Donker, Erik M., Spitaleri Timpone, Pietro, Hagen, Charlotte A.M., Richir, Milan C., van Agtmael, Michiel A., De Ponti, Fabrizio, Tichelaar, Jelle, Bakkum, Michiel J., Donker, Erik M., Spitaleri Timpone, Pietro, Hagen, Charlotte A.M., Richir, Milan C., van Agtmael, Michiel A., De Ponti, Fabrizio, and Tichelaar, Jelle

Published
2023

32. A Clinical Pharmacology and Therapeutics Teacher's Guide to Race-Based Medicine, Inclusivity, and Diversity

Author

Bakkum, Michiel J., Verdonk, Petra, Thomas, Elias G., van Rosse, Floor, Okorie, Michael, Papaioannidou, Paraskevi, Likic, Robert, Sanz, Emilio J., Christiaens, Thierry, Costa, João N., Dima, Lorena, de Ponti, Fabrizio, van Smeden, Jeroen, van Agtmael, Michiel A., Richir, Milan C., Tichelaar, Jelle, Bakkum, Michiel J., Verdonk, Petra, Thomas, Elias G., van Rosse, Floor, Okorie, Michael, Papaioannidou, Paraskevi, Likic, Robert, Sanz, Emilio J., Christiaens, Thierry, Costa, João N., Dima, Lorena, de Ponti, Fabrizio, van Smeden, Jeroen, van Agtmael, Michiel A., Richir, Milan C., and Tichelaar, Jelle

Abstract

The relationship between race and biology is complex. In contemporary medical science, race is a social construct that is measured via self-identification of study participants. But even though race has no biological essence, it is often used as variable in medical guidelines (e.g., treatment recommendations specific for Black people with hypertension). Such recommendations are based on clinical trials in which there was a significant correlation between self-identified race and actual, but often unmeasured, health-related factors such as (pharmaco)genetics, diet, sun exposure, etc. Many teachers are insufficiently aware of this complexity. In their classes, they (unintentionally) portray self-reported race as having a biological essence. This may cause students to see people of shared race as biologically or genetically homogeneous, and believe that race-based recommendations are true for all individuals (rather than reflecting the average of a heterogeneous group). This medicalizes race and reinforces already existing healthcare disparities. Moreover, students may fail to learn that the relation between race and health is easily biased by factors such as socioeconomic status, racism, ancestry, and environment and that this limits the generalizability of race-based recommendations. We observed that the clinical case vignettes that we use in our teaching contain many stereotypes and biases, and do not generally reflect the diversity of actual patients. This guide, written by clinical pharmacology and therapeutics teachers, aims to help our colleagues and teachers in other health professions to reflect on and improve our teaching on race-based medical guidelines and to make our clinical case vignettes more inclusive and diverse.

Published
2023

33. The Dutch list of essential drugs for undergraduate medical education:A modified Delphi study

Author

Donker, Erik M., Pandit, Rahul, Poleij, Merel C.S., Brinkman, David J., van Agtmael, Michiel A., van Rosse, Floor, Dumont, Glenn, Kramers, Cornelis, Atiqi, Roya, Richir, Milan C., van Smeden, Jeroen, Hessel, Marleen H.M., Janssen, Ben J., Knol, Wilma, Tichelaar, Jelle, Donker, Erik M., Pandit, Rahul, Poleij, Merel C.S., Brinkman, David J., van Agtmael, Michiel A., van Rosse, Floor, Dumont, Glenn, Kramers, Cornelis, Atiqi, Roya, Richir, Milan C., van Smeden, Jeroen, Hessel, Marleen H.M., Janssen, Ben J., Knol, Wilma, and Tichelaar, Jelle

Abstract

Aims: Prescribing errors among junior doctors are common in clinical practice because many lack prescribing competence after graduation. This is in part due to inadequate education in clinical pharmacology and therapeutics (CP&T) in the undergraduate medical curriculum. To support CP&T education, it is important to determine which drugs medical undergraduates should be able to prescribe safely and effectively without direct supervision by the time they graduate. Currently, there is no such list with broad-based consensus. Therefore, the aim was to reach consensus on a list of essential drugs for undergraduate medical education in the Netherlands. Methods: A two-round modified Delphi study was conducted among pharmacists, medical specialists, junior doctors and pharmacotherapy teachers from all eight Dutch academic hospitals. Participants were asked to indicate whether it was essential that medical graduates could prescribe specific drugs included on a preliminary list. Drugs for which ≥80% of all respondents agreed or strongly agreed were included in the final list. Results: In all, 42 (65%) participants completed the two Delphi rounds. A total of 132 drugs (39%) from the preliminary list and two (3%) newly proposed drugs were included. Conclusions: This is the first Delphi consensus study to identify the drugs that Dutch junior doctors should be able to prescribe safely and effectively without direct supervision. This list can be used to harmonize and support the teaching and assessment of CP&T. Moreover, this study shows that a Delphi method is suitable to reach consensus on such a list, and could be used for a European list.

Published
2023

34. Correction: Limited wedge resection for T1 colon cancer (LIMERIC-II trial) - rationale and study protocol of a prospective multicenter clinical trial

Author

MS MDL 1, Cancer, Pathologie Pathologen staf, MS CGO, Hanevelt, Julia, Huisman, Jelle F, Leicher, Laura W, Lacle, Miangela M, Richir, Milan C, Didden, Paul, Geesing, Joost M J, Smakman, Niels, Sive Droste, Jochim S Terhaar, Ter Borg, Frank, Talsma, A Koen, Schrauwen, Ruud W M, van Wely, Bob J, Schot, Ingrid, Vermaas, Maarten, Bos, Philip, Sietses, Colin, Hazen, Wouter L, Wasowicz, Dareczka K, Ploeg, David E, Ramsoekh, Dewkoemar, Tuynman, Jurriaan B, Alderlieste, Yasser A, Renger, Rutger-Jan, Schreuder, Ramon-Michel, Bloemen, Johanne G, van Lijnschoten, Ineke, Consten, Esther C J, Sikkenk, Daan J, Schwartz, Matthijs P, Vos, Annelotte, Burger, Jordy P W, Spanier, Bernhard W M, Knijn, Nikki, Cappel, Wouter H de Vos Tot Nederveen, Moons, Leon M G, van Westreenen, Henderik L, MS MDL 1, Cancer, Pathologie Pathologen staf, MS CGO, Hanevelt, Julia, Huisman, Jelle F, Leicher, Laura W, Lacle, Miangela M, Richir, Milan C, Didden, Paul, Geesing, Joost M J, Smakman, Niels, Sive Droste, Jochim S Terhaar, Ter Borg, Frank, Talsma, A Koen, Schrauwen, Ruud W M, van Wely, Bob J, Schot, Ingrid, Vermaas, Maarten, Bos, Philip, Sietses, Colin, Hazen, Wouter L, Wasowicz, Dareczka K, Ploeg, David E, Ramsoekh, Dewkoemar, Tuynman, Jurriaan B, Alderlieste, Yasser A, Renger, Rutger-Jan, Schreuder, Ramon-Michel, Bloemen, Johanne G, van Lijnschoten, Ineke, Consten, Esther C J, Sikkenk, Daan J, Schwartz, Matthijs P, Vos, Annelotte, Burger, Jordy P W, Spanier, Bernhard W M, Knijn, Nikki, Cappel, Wouter H de Vos Tot Nederveen, Moons, Leon M G, and van Westreenen, Henderik L

Published
2023

35. The augmented value of using clinical notes in semi-automated surveillance of deep surgical site infections after colorectal surgery

Author

Epi Infectieziekten, MS CGO, Cancer, MMB Medische Staf, Infection & Immunity, Verberk, Janneke D M, van der Werff, Suzanne D, Weegar, Rebecka, Henriksson, Aron, Richir, Milan C, Buchli, Christian, van Mourik, Maaike S M, Nauclér, Pontus, Epi Infectieziekten, MS CGO, Cancer, MMB Medische Staf, Infection & Immunity, Verberk, Janneke D M, van der Werff, Suzanne D, Weegar, Rebecka, Henriksson, Aron, Richir, Milan C, Buchli, Christian, van Mourik, Maaike S M, and Nauclér, Pontus

Published
2023

36. Limited wedge resection for T1 colon cancer (LIMERIC-II trial) - rationale and study protocol of a prospective multicenter clinical trial

Author

Pathologie Pathologen staf, Cancer, MS CGO, MS MDL 1, Hanevelt, Julia, Huisman, Jelle F, Leicher, Laura W, Lacle, Miangela M, Richir, Milan C, Didden, Paul, Geesing, Joost M J, Smakman, Niels, Droste, Jochim S Terhaar Sive, Ter Borg, Frank, Talsma, A Koen, Schrauwen, Ruud W M, van Wely, Bob J, Schot, Ingrid, Vermaas, Maarten, Bos, Philip, Sietses, Colin, Hazen, Wouter L, Wasowicz, Dareczka K, Ploeg, David E, Ramsoekh, Dewkoemar, Tuynman, Jurriaan B, Alderlieste, Yasser A, Renger, Rutger-Jan, Schreuder, Ramon-Michel, Bloemen, Johanne G, van Lijnschoten, Ineke, Consten, Esther C J, Sikkenk, Daan J, Schwartz, Matthijs P, Vos, Annelotte, Burger, Jordy P W, Spanier, Bernhard W M, Knijn, Nikki, de Vos Tot Nederveen Cappel, Wouter H, Moons, Leon M G, van Westreenen, Henderik L, Pathologie Pathologen staf, Cancer, MS CGO, MS MDL 1, Hanevelt, Julia, Huisman, Jelle F, Leicher, Laura W, Lacle, Miangela M, Richir, Milan C, Didden, Paul, Geesing, Joost M J, Smakman, Niels, Droste, Jochim S Terhaar Sive, Ter Borg, Frank, Talsma, A Koen, Schrauwen, Ruud W M, van Wely, Bob J, Schot, Ingrid, Vermaas, Maarten, Bos, Philip, Sietses, Colin, Hazen, Wouter L, Wasowicz, Dareczka K, Ploeg, David E, Ramsoekh, Dewkoemar, Tuynman, Jurriaan B, Alderlieste, Yasser A, Renger, Rutger-Jan, Schreuder, Ramon-Michel, Bloemen, Johanne G, van Lijnschoten, Ineke, Consten, Esther C J, Sikkenk, Daan J, Schwartz, Matthijs P, Vos, Annelotte, Burger, Jordy P W, Spanier, Bernhard W M, Knijn, Nikki, de Vos Tot Nederveen Cappel, Wouter H, Moons, Leon M G, and van Westreenen, Henderik L

Published
2023

37. Risk factors of postoperative intensive care unit admission during the COVID-19 pandemic: A multicentre retrospective cohort study

Author

MS CGO, Cancer, Heelkunde Opleiding, de Bock, Ellen, Filipe, Mando D, Herman, Eline S, Pronk, Apollo, Boerma, Djamila, Heikens, Joost T, Verheijen, Paul M, Vriens, Menno R, Richir, Milan C, MS CGO, Cancer, Heelkunde Opleiding, de Bock, Ellen, Filipe, Mando D, Herman, Eline S, Pronk, Apollo, Boerma, Djamila, Heikens, Joost T, Verheijen, Paul M, Vriens, Menno R, and Richir, Milan C

Published
2023

38. Breast carcinoma detection in ex vivo fresh human breast surgical specimens using a fast slide-free confocal microscopy scanner: HIBISCUSS project

Author

Pathologie, Cancer, MS CGO, Conversano, Angelica, Abbaci, Muriel, van Diest, Paul, Roulot, Aurélie, Falco, Giuseppe, Ferchiou, Malek, Coiro, Saverio, Richir, Milan, Genolet, Pierre-Michel, Clement, Carine, Casiraghi, Odile, Lahkdar, Aicha Ben, Labaied, Nizard, Ragazzi, Moira, Mathieu, Marie-Christine, Pathologie, Cancer, MS CGO, Conversano, Angelica, Abbaci, Muriel, van Diest, Paul, Roulot, Aurélie, Falco, Giuseppe, Ferchiou, Malek, Coiro, Saverio, Richir, Milan, Genolet, Pierre-Michel, Clement, Carine, Casiraghi, Odile, Lahkdar, Aicha Ben, Labaied, Nizard, Ragazzi, Moira, and Mathieu, Marie-Christine

Published
2023

39. The Dutch list of essential drugs for undergraduate medical education: A modified Delphi study

Author

TN Onderwijs, MS CGO, Cancer, MS Geriatrie, Circulatory Health, Apotheek O&O&O, Donker, Erik M, Pandit, Rahul, Poleij, Merel C S, Brinkman, David J, van Agtmael, Michiel A, van Rosse, Floor, Dumont, Glenn, Kramers, Cornelis, Atiqi, Roya, Richir, Milan C, van Smeden, Jeroen, Hessel, Marleen H M, Janssen, Ben J, Knol, Wilma, Tichelaar, Jelle, Pharmacotherapy Education working group of the Dutch Society for Clinical Pharmacology & Biopharmacy and its affiliated Dutch Network of Clinical Pharmacology Teachers, TN Onderwijs, MS CGO, Cancer, MS Geriatrie, Circulatory Health, Apotheek O&O&O, Donker, Erik M, Pandit, Rahul, Poleij, Merel C S, Brinkman, David J, van Agtmael, Michiel A, van Rosse, Floor, Dumont, Glenn, Kramers, Cornelis, Atiqi, Roya, Richir, Milan C, van Smeden, Jeroen, Hessel, Marleen H M, Janssen, Ben J, Knol, Wilma, Tichelaar, Jelle, and Pharmacotherapy Education working group of the Dutch Society for Clinical Pharmacology & Biopharmacy and its affiliated Dutch Network of Clinical Pharmacology Teachers

Published
2023

40. Can surgeons detect breast carcinoma in ex-vivo fresh human breast surgical specimens? A feasibility study using ultra-fast slide-free confocal microscopy

Author

Conversano, Angelica, primary, Abbaci, Muriel, additional, Casiraghi, Odile, additional, Labaied, Nizard, additional, Ferchiou, Malek, additional, Coiro, Saverio, additional, Falco, Giuseppe, additional, Richir, Milan, additional, Genolet, Pierre-Michel, additional, Clement, Carine, additional, Van Diest, Paul, additional, Ragazzi, Moira, additional, Roulot, Aurélie, additional, and Mathieu, Marie-Christine, additional

Published
2023
Full Text
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41. The Dutch list of essential drugs for undergraduate medical education: A modified Delphi study

Author

Pharmacotherapy Education working group of the Dutch Society for Clinical Pharmacology & Biopharmacy and its affiliated Dutch Network of Clinical Pharmacology Teachers, Donker, Erik M, Pandit, Rahul, Poleij, Merel C S, Brinkman, David J, van Agtmael, Michiel A, van Rosse, Floor, Dumont, Glenn, Kramers, Cornelis, Atiqi, Roya, Richir, Milan C, van Smeden, Jeroen, Hessel, Marleen H M, Janssen, Ben J, Knol, Wilma, Tichelaar, Jelle, Bravenboer, Bert, Pharmacy, Internal medicine, Anesthesiology, AGEM - Endocrinology, metabolism and nutrition, Other Research, APH - Quality of Care, Vriendenkring VUB, Diabetes Clinic, Clinical sciences, Farmacologie en Toxicologie, and RS: Carim - H03 ECM and Wnt signaling

Subjects
Pharmacology, Pharmacology, Toxicology and Pharmaceutics(all), pharmacotherapy, All institutes and research themes of the Radboud University Medical Center, pharmacology teaching, Pharmacology (medical), clinical pharmacology, medical education, Healthcare improvement science Radboud Institute for Health Sciences [Radboudumc 18]
Abstract

Contains fulltext : 290940.pdf (Publisher’s version ) (Open Access) AIMS: Prescribing errors among junior doctors are common in clinical practice because many lack prescribing competence after graduation. This is in part due to inadequate education in clinical pharmacology and therapeutics (CP&T) in the undergraduate medical curriculum. To support CP&T education, it is important to determine which drugs medical undergraduates should be able to prescribe safely and effectively without direct supervision by the time they graduate. Currently, there is no such list with broad-based consensus. Therefore, the aim was to reach consensus on a list of essential drugs for undergraduate medical education in the Netherlands. METHODS: A two-round modified Delphi study was conducted among pharmacists, medical specialists, junior doctors and pharmacotherapy teachers from all eight Dutch academic hospitals. Participants were asked to indicate whether it was essential that medical graduates could prescribe specific drugs included on a preliminary list. Drugs for which ≥80% of all respondents agreed or strongly agreed were included in the final list. RESULTS: In all, 42 (65%) participants completed the two Delphi rounds. A total of 132 drugs (39%) from the preliminary list and two (3%) newly proposed drugs were included. CONCLUSIONS: This is the first Delphi consensus study to identify the drugs that Dutch junior doctors should be able to prescribe safely and effectively without direct supervision. This list can be used to harmonize and support the teaching and assessment of CP&T. Moreover, this study shows that a Delphi method is suitable to reach consensus on such a list, and could be used for a European list. 01 april 2023

Published
2023

44. Do we become better prescribers after graduation: A 1-year international follow-up study among junior doctors

Author

Education committee of the Dutch Society for Clinical Pharmacology and Biopharmacy, Donker, Erik M, Brinkman, David J, van Rosse, Floor, Janssen, Ben, Knol, Wilma, Dumont, Glenn, Jorens, Philippe G, Dupont, Alain, Christiaens, Thierry, van Smeden, Jeroen, de Waard-Siebinga, Itte, Peeters, Laura E J, Goorden, Ronald, Hessel, Marleen, Lissenberg-Witte, Birgit, Richir, Milan, van Agtmael, Michiel A, Kramers, Cornelis, Tichelaar, Jelle, Internal medicine, Amsterdam Gastroenterology Endocrinology Metabolism, Epidemiology and Data Science, APH - Methodology, Other Research, APH - Quality of Care, Pharmaceutical and Pharmacological Sciences, Clinical Pharmacology and Clinical Pharmacy, Farmacologie en Toxicologie, RS: Carim - H03 ECM and Wnt signaling, Dutch Society for Clinical Pharmacology and Biopharmacy, Pharmacy, Internal Medicine, Graduate School, Tytgat Institute for Liver and Intestinal Research, AGEM - Amsterdam Gastroenterology Endocrinology Metabolism, APH - Mental Health, and APH - Personalized Medicine

Subjects
Pharmacology, Pharmacology. Therapy, education, ERRORS, PERFORMANCE, Healthcare improvement science Radboud Institute for Health Sciences [Radboudumc 18], PHARMACOLOGY KNOWLEDGE, Pharmacology, Toxicology and Pharmaceutics(all), pharmacotherapy, Medical Staff, Hospital, SKILLS, Humans, Pharmacology (medical), Clinical Competence, Longitudinal Studies, clinical pharmacology, graduate, Practice Patterns, Physicians', medical education, prescribing knowledge and skills, Follow-Up Studies
Abstract

Contains fulltext : 286840.pdf (Publisher’s version ) (Open Access) AIM: The aim of this study was to investigate how the prescribing knowledge and skills of junior doctors in the Netherlands and Belgium develop in the year after graduation. We also analysed differences in knowledge and skills between surgical and nonsurgical junior doctors. METHODS: This international, multicentre (n = 11), longitudinal study analysed the learning curves of junior doctors working in various specialties via three validated assessments at about the time of graduation, and 6 months and 1 year after graduation. Each assessment contained 35 multiple choice questions (MCQs) on medication safety (passing grade ≥85%) and three clinical scenarios. RESULTS: In total, 556 junior doctors participated, 326 (58.6%) of whom completed the MCQs and 325 (58.5%) the clinical case scenarios of all three assessments. Mean prescribing knowledge was stable in the year after graduation, with 69% (SD 13) correctly answering questions at assessment 1 and 71% (SD 14) at assessment 3, whereas prescribing skills decreased: 63% of treatment plans were considered adequate at assessment 1 but only 40% at assessment 3 (P

Published
2022

45. Environmentally sustainable prescribing: recommendations for EU pharmaceutical legislation

Author

Piët, Joost D, Booth, Amy, Donker, Erik M, de Ponti, Fabrizio, Lunghi, Carlotta, Poluzzi, Elisabetta, Janssen, Ben J A, Tun, SanYuMay, Bekker, Charlotte, Dima, Lorena, Costa, João, Jalving, Mathilde, Oude Munnink, Thijs H, van den Bemt, Patricia M L A, Labriffe, Marc, van Emden, Tomás, van Waardenburg, Vera, Likic, Robert, Richir, Milan, van Agtmael, Michiel A, Moermond, Caroline T A, and Tichelaar, Jelle

Published
2024
Full Text
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48. Do we become better prescribers after graduation:A 1-year international follow-up study among junior doctors

Author

Donker, Erik M., Brinkman, David J., van Rosse, Floor, Janssen, Ben, Knol, Wilma, Dumont, Glenn, Jorens, Philippe G., Dupont, Alain, Christiaens, Thierry, van Smeden, Jeroen, de Waard-Siebinga, Itte, Peeters, Laura E.J., Goorden, Ronald, Hessel, Marleen, Lissenberg-Witte, Birgit, Richir, Milan, van Agtmael, Michiel A., Kramers, Cornelis, Tichelaar, Jelle, Donker, Erik M., Brinkman, David J., van Rosse, Floor, Janssen, Ben, Knol, Wilma, Dumont, Glenn, Jorens, Philippe G., Dupont, Alain, Christiaens, Thierry, van Smeden, Jeroen, de Waard-Siebinga, Itte, Peeters, Laura E.J., Goorden, Ronald, Hessel, Marleen, Lissenberg-Witte, Birgit, Richir, Milan, van Agtmael, Michiel A., Kramers, Cornelis, and Tichelaar, Jelle

Abstract

Aim: The aim of this study was to investigate how the prescribing knowledge and skills of junior doctors in the Netherlands and Belgium develop in the year after graduation. We also analysed differences in knowledge and skills between surgical and nonsurgical junior doctors. Methods: This international, multicentre (n = 11), longitudinal study analysed the learning curves of junior doctors working in various specialties via three validated assessments at about the time of graduation, and 6 months and 1 year after graduation. Each assessment contained 35 multiple choice questions (MCQs) on medication safety (passing grade ≥85%) and three clinical scenarios. Results: In total, 556 junior doctors participated, 326 (58.6%) of whom completed the MCQs and 325 (58.5%) the clinical case scenarios of all three assessments. Mean prescribing knowledge was stable in the year after graduation, with 69% (SD 13) correctly answering questions at assessment 1 and 71% (SD 14) at assessment 3, whereas prescribing skills decreased: 63% of treatment plans were considered adequate at assessment 1 but only 40% at assessment 3 (P <.001). While nonsurgical doctors had similar learning curves for knowledge and skills as surgical doctors (P =.53 and P =.56 respectively), their overall level was higher at all three assessments (all P <.05). Conclusion: These results show that junior doctors' prescribing knowledge and skills did not improve while they were working in clinical practice. Moreover, their level was under the predefined passing grade. As this might adversely affect patient safety, educational interventions should be introduced to improve the prescribing competence of junior doctors.

Published
2022

50. Meta-analysis of COVID-19 prevalence during preoperative COVID-19 screening in asymptomatic patients

Author

MS CGO, Cancer, Infection & Immunity, DHS-Medisch, Other research (not in main researchprogram), Medische staf Anesthesiologie, Heelkunde Opleiding, de Bock, Ellen, Filipe, Mando D, Simmermacher, Roger K J, Kroese, A Christiaan, Vriens, Menno R, Richir, Milan C, MS CGO, Cancer, Infection & Immunity, DHS-Medisch, Other research (not in main researchprogram), Medische staf Anesthesiologie, Heelkunde Opleiding, de Bock, Ellen, Filipe, Mando D, Simmermacher, Roger K J, Kroese, A Christiaan, Vriens, Menno R, and Richir, Milan C

Published
2022

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