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284 results on '"Richeval Camille"'

6. N-Ethylhexedrone: A very long and bad trip! A case series.

Author

Lefeuvre, Sandrine, Richeval, Camille, Lelong, Jeremy, Venisse, Nicolas, Humbert, Luc, and Brunet, Bertrand

Subjects
*LIQUID chromatography-mass spectrometry, *INAPPROPRIATE ADH syndrome, *LOSS of consciousness, *DRUGS of abuse, *DRUG utilization
Abstract

N-ethylhexedrone (NEH) is a new cathinone derivative with, currently, low toxicokinetic and toxicodynamic knowledge. We present three documented clinical cases of NEH intoxication with plasma and urine concentrations. A thorough search for metabolites was performed. The three patients were admitted to the emergency department, and two out of the three were hospitalized for an extended period. While recovering from the drug effects, 12–24 h after nasal intake of New Psychoactive Substance (NPS), the patients described the following disorders: anxiety, feelings of persecution, asthenia, anhedonia, abulia, psychomotor slowing and loss of consciousness. NEH was identified in all samples by liquid chromatography–high resolution mass spectrometry (LC–HRMS), and quantified by liquid chromatography coupled to tandem mass spectrometry (LC–MS-MS). Quantitative analysis showed decreasing concentrations over time: for Case 1, from 97.2 (Day 1, D1) to 0.7 (Day 7, D7) µg/L for plasma, and from 724 (D1) to 0.5 (D7) µg/L for urine. NEH concentration of 7.9 µg/L was found in the plasma collected at admission for Case 2. For Case 3, concentrations ranging from 49 (D1) to 1.8 (D7) µg/L in plasma, and from 327.3 (Day 6, D6) to 116.8 (D7) µg/L in urine were found. NEH was no longer detected in the urine sample at Day 10. Elimination half-life was estimated at 19, and 28 hours in Patients 1 and 3, respectively. Four metabolites were identified in blood and urine: reduced NEH, dealkyl-NEH, reduced dealkyl-NEH and hydroxy-NEH. The cases presented highlight the long detectable lifetime of NEH. Characterization of the metabolites will allow better identification of the consumption of this drug. Serious adverse events can be observed after NEH consumption, as two out of the three patients required intubation and ventilation. A syndrome of inappropriate antidiuretic hormone secretion (SIADH) was also diagnosed. Two out of the three cases are notable because of the number of samples collected and because NEH was the only drug of abuse detected. [ABSTRACT FROM AUTHOR]

Published
2024
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8. A current overview of the pharmacological composition of "La Chimique" consumed in Mayotte: Preliminary results of the CHASSE‐MAREE protocol.

Author

Richeval, Camille, Gish, Alexandr, Cottereau, Victoire, Peyre, Alexandre, Pleignet, Eric, Cherki, Sabrina, Allorge, Delphine, Gaulier, Jean‐Michel, and Devault, Damien A.

Abstract

Mayotte Island, a French department located in the Mozambique Channel, has for several years been faced with the consumption of "La Chimique" (LC), reputed (but extremely poorly documented) to be a mixture of tobacco and synthetic cannabinoid receptor agonists (SCRAs). One of the objectives of the CHASSE‐MAREE protocol is to assess the composition and heterogeneity of LC products through successive LC sample collection campaigns among users. Currently underway, we present here the first analytical results (samples collected in 2022). Between September and December 2022, 80 samples were collected throughout the island over three periods: 70 in the usual form of LC (small folded papers containing a plant‐like sample, mostly tobacco), 6 powders, and 4 cigarettes. Analysis was performed using liquid chromatography with high‐resolution mass spectrometry. The detected substances (number of detections) included SCRAs (MDMB‐4en‐PINACA [35], ADB‐FUBIATA [25], MDMB‐INACA [16], ADB‐BUTINACA [15], AFUBIATA [11], 4F‐MDMD‐BICA [7], CH‐PIATA [14], 5C‐APINACA [3], BZO‐HEXOXIZID [2], and 4F‐ABINACA [1]), nicotine (68), tetrahydrocannabinol (THC), cannabinol (CBN), and cannabidiol (CBD) (2), medications (amantadine [11], cyamemazine [6], and acetaminophen [3]), and a designer benzodiazepine (bromazolam [4]). The SCRAs currently in use are varied, and the market for "cooks" (those who prepare LC) is dispersed according to where and when samples are collected. These preliminary results will be supplemented by analysis of samples collected in the first half of 2023 and by an improved description of the current panorama of consumption of LC in Mayotte (mapping, effects felt and dependence, etc.). [ABSTRACT FROM AUTHOR]

Published
2024
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11. Étude pilote du projet IN CADAVER : preuve de concept d’une voie future de la toxicologie post-mortem (et nouveau paradigme ?)

Author

Gaulier, Jean-Michel, primary, Gish, Alexandr, additional, Ghoul, Caroline, additional, Bertrand N Doye, Myriam, additional, Girard, Hugo, additional, Scanvion, Quentin, additional, Goldsztajn, Dorine, additional, Hakim, Florian, additional, Richeval, Camille, additional, Wiart, Jean-François, additional, Humbert, Luc, additional, Delannoy, Yann, additional, Hédouin, Valéry, additional, and Allorge, Delphine, additional

Published
2023
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12. « Poison violent du Cameroun »

Author

Salle, Sophie, primary, Gish, Alexandr, additional, Le Roux, Gaël, additional, Hakim, Florian, additional, Richeval, Camille, additional, Wiart, Jean-François, additional, Humbert, Luc, additional, Allorge, Delphine, additional, and Gaulier, Jean-Michel, additional

Published
2023
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18. Commentaires sur l’article « Acide γ-Hydroxybutyrique (GHB), γ-butyrolactone (GBL) et 1,4-butanediol (1,4-BD) : revue de la littérature des aspects pharmacologiques, cliniques, analytiques et médico-légaux » (Toxicol Anal Clin 2023;35(1):1-22). Les cas d’exposition/intoxication au GHB, ce n’est pas de la soumission chimique mais c’est majoritairement du Chemsex !

Author

Hakim, Florian, Saint-Omer, Apolline, Gish, Alexandr, Grenier, Corentin, Hennart, Benjamin, Wiart, Jean-François, Richeval, Camille, Humbert, Luc, Cornez, Raphael, Allorge, Delphine, and Gaulier, Jean-Michel

Published
2023
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30. At the Origins of Tobacco-Smoking and Tea Consumption in a Virgin Population (Yakutia, 1650–1900 A.D.): Comparison of Pharmacological, Histological, Economic and Cultural Data

Author

Macé, Matthias, primary, Richeval, Camille, additional, Alcouffe, Ameline, additional, Romanova, Liubomira, additional, Gérard, Patrice, additional, Duchesne, Sylvie, additional, Cannet, Catherine, additional, Boyarskikh, Irina, additional, Géraut, Annie, additional, Zvénigorosky, Vincent, additional, Nikolaeva, Darya, additional, Stepanoff, Charles, additional, Allorge, Delphine, additional, Debrenne, Michele, additional, Telmon, Norbert, additional, Ludes, Bertrand, additional, Alexeev, Anatoly, additional, Gaulier, Jean-Michel, additional, and Crubézy, Eric, additional

Published
2021
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31. Metabolite elucidation of 2‐fluoro‐deschloroketamine (2F‐DCK) using molecular networking across three complementary in vitro and in vivo models

Author

Gicquel, Thomas, primary, Pelletier, Romain, additional, Richeval, Camille, additional, Gish, Alexandr, additional, Hakim, Florian, additional, Ferron, Pierre‐Jean, additional, Mesli, Vadim, additional, Allorge, Delphine, additional, Morel, Isabelle, additional, and Gaulier, Jean‐michel, additional

Published
2021
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33. In vivo (in cadaver), in vitro, in silico et modélisation par réseaux moléculaires : documentation analytique et métabolique de la 2-Fluoro-DeschloroKétamine (2F-DCK) à l’occasion d’un décès

Author

Gicquel, Thomas, primary, Richeval, Camille, additional, Pelletier, Romain, additional, Gish, Alexandr, additional, Hakim, Florian, additional, Cornez, Raphael, additional, Balgairies, Axelle, additional, Mesli, Vadim, additional, Allorge, Delphine, additional, Morel, Isabelle, additional, and Gaulier, Jean-Michel, additional

Published
2021
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35. N-éthylhexédrone : une longue descente !

Author

Lefeuvre, Sandrine, primary, Richeval, Camille, additional, Kramer-Ruggiu, Benjamine, additional, Lelong, Jérémy, additional, Venisse, Nicolas, additional, Delcoustal, Michel, additional, Gorry, Crisanda, additional, Humbert, Luc, additional, and Brunet, Bertrand, additional

Published
2021
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38. Intoxication sévère par cardiotropes avec monitoring en temps réel des concentrations sanguines

Author

Gish, Alexandr, primary, Onimus, Thierry, additional, Durand, Arthur, additional, Goutay, Julien, additional, Hennart, Benjamin, additional, Hakim, Florian, additional, Castex, Eugenie, additional, Richeval, Camille, additional, Wiart, Jean-Francois, additional, Humbert, Luc, additional, Allorge, Delphine, additional, and Gaulier, Jean-Michel, additional

Published
2021
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41. Case report on two-cathinones abuse: MPHP and N-ethyl-4′methylnorpentedrone, with a fatal outcome

Author

Iwanikow Deborah, Coulon Audrey, Allorge Delphine, Deguigne Marie, Ferec Severine, Drevin Guillaume, Brofferio Morgan, Gaulier Jean-Michel, Richeval Camille, Jousset Nathalie, Boels David, and Lelievre Benedicte

Subjects
Fatal outcome, Chromatography, Chemistry, 010401 analytical chemistry, Biochemistry (medical), Blood ethanol, Context (language use), Urine, Toxicology, Mass spectrometry, 01 natural sciences, Diode array, 0104 chemical sciences, Pathology and Forensic Medicine, 03 medical and health sciences, 0302 clinical medicine, medicine, 030216 legal & forensic medicine, Gas chromatography, Tetrahydrocannabinol, medicine.drug
Abstract

The correlation between the rising consumption of new psychoactive drugs (NPS), including that of cathinones, and the occurrence of death has not been sufficiently backed up with published analytic data. In fact, the identification of cathinones in human biological samples remains difficult mainly due to the diversity of these substances and their high turnover. In this context, this manuscript aims at documenting a fatal case of a 39-year-old man: autopsy findings consisted in unspecific asphyxic syndrome. Blood ethanol concentration determination and toxicological screenings were performed using gas chromatography with flame ionization detection, liquid chromatography with diode array detection and gas chromatography with mass spectrometry detection, respectively. Liquid chromatography with high-resolution mass spectrometry detection allowed the confirmation of the presence of NPS and the subsequent metabolic study. The analyses have shown the presence of ethanol, tetrahydrocannabinol and two cathinones, 4′-methyl-α-pyrrolidinohexanophenone (MPHP) and N-ethyl-4′-methylnorpentedrone (4-MEAP). MPHP/4-MEAP concentrations were 47/1.6, 97/3.5 and 2380/49,700 µg/L in femoral blood, cardiac blood and urine, respectively. The in vitro metabolic study has highlighted the presence of five metabolites derived from MPHP and three from 4-MEAP but only two metabolites of these products have been detected in biological samples. The 4′-carboxy-PHP, one of the metabolites of MPHP, was detected in every biological sample with higher chromatographic signals than MPHP itself. The number of fatalities related to cathinones use is expected to increase in the coming years. This manuscript reports useful analytical data about MPHP, one of its metabolites (4′-carboxy-PHP) and 4-MEAP.

Published
2019

43. Intoxication sévère par cardiotropes avec suivi en temps réel des concentrations sanguines

Author

Gish, Alexandr, primary, Onimus, Thierry, additional, Durand, Arthur, additional, Goutay, Julien, additional, Hennart, Benjamin, additional, Hakim, Florian, additional, Castex, Eugenie, additional, Richeval, Camille, additional, Wiart, Jean-François, additional, Humbert, Luc, additional, Allorge, Delphine, additional, and Gaulier, Jean-Michel, additional

Published
2021
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44. Impact of socio-economic traditions on current tobacco and tea addictions (Siberia 17 th to 20 th century)

Author

Macé, Matthias, Richeval, Camille, Gérard, Patrice, Duchesne, Sylvie, Cannet, Catherine, Boyarskikh, Irina, Gérault, Annie, Zvénigorosky, Vincent, Nikolaeva, Darya, Stépanoff, Charles, Allorge, Delphine, Debrenne, Michele, Ludes, Bertrand, Alexeev, Anatoly, Gaulier, Jean-Michel, Crubezy, E., CRUBEZY, Eric, Evolution et Diversité Biologique (EDB), Institut de Recherche pour le Développement (IRD)-Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Université de Toulouse (UT)-Centre National de la Recherche Scientifique (CNRS), Toxicologie et Génopathies [CHRU Lille], Pôle de Biologie Pathologie Génétique [CHU Lille], Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille)-Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille), Centre d'anthropologie et de génomique de Toulouse (CAGT), Université Toulouse III - Paul Sabatier (UT3), Institut de Médecine Légale [Strasbourg], Université Louis Pasteur - Strasbourg I, École Pratique des Hautes Études (EPHE), Université Paris sciences et lettres (PSL), Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD)-Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées, Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Centre National de la Recherche Scientifique (CNRS), and École pratique des hautes études (EPHE)

Subjects
[SHS.ARCHEO] Humanities and Social Sciences/Archaeology and Prehistory, [SHS.ARCHEO]Humanities and Social Sciences/Archaeology and Prehistory, [SDV]Life Sciences [q-bio], [SHS.ANTHRO-BIO]Humanities and Social Sciences/Biological anthropology, [SHS.RELIG] Humanities and Social Sciences/Religions, [SHS]Humanities and Social Sciences, [SHS.RELIG]Humanities and Social Sciences/Religions, [SHS.ANTHRO-BIO] Humanities and Social Sciences/Biological anthropology, [SDV] Life Sciences [q-bio], [SHS.ENVIR] Humanities and Social Sciences/Environmental studies, [SHS.ENVIR]Humanities and Social Sciences/Environmental studies, [SHS.HIST] Humanities and Social Sciences/History, [SHS] Humanities and Social Sciences, [SHS.HIST]Humanities and Social Sciences/History
Abstract

ObjectiveTo investigate how tobacco and tea spread among virgin populations and how the first addictions have subsequently influenced the behavior of present-day populations.DesignRetrospective observational study using data from frozen burials and levels of theobromine, theophylline, caffeine, nicotine, and cotinine measured in hair samples from frozen bodies of autochthonous people. Confrontation of the results with new ethnobotanical, historical and cultural data from the past and with present day epidemiological data from the same region.SettingEastern Siberia (Yakutia) from the contact with Europeans (17th century) to the assimilation of people into Russian society (19th century).Participants47 frozen bodies of autochthonous people from eastern Siberia and a review of present-day populations from YakutiaInterventionLevels of theobromine, theophylline, caffeine, nicotine, and cotinine were measured in hair samples. Along with the collection of cultural data associated with the bodies, potential comorbidities were investigated.Main outcome measureWe combined LC-HRMS and LC-MS/MS tools for toxicological investigations in hair and we assessed the association between xenobiotic concentrations and geography using several permutation-based methods to infer the economic circuits of tobacco and tea. Comparison of the results obtained with ethno-botanical analyses allowed to identify the products from which the metabolites were derived.ResultsHair levels of theobromine, theophylline and caffeine vary with the type of beverage consumed: green, black or local herbal teas. At the beginning of our study period, a few heavy consumers of tobacco were found among light or passive consumers. Tobacco-related co-morbidities began to be recorded one century after contact with Europeans. Heavy tea users were only found from the 19th century and the heaviest users of the two substances date from this century. After the first contact, teas were widely consumed as beverages and medicines but also for shamanic reasons. Economic factors, fashion and social and family contacts seem to have played a decisive role in tobacco consumption very early on.ConclusionEpidemiological characteristics of present-day Yakutia suggest that the high prevalence of smokers and tea consumers, the prevalence of female smokers and tobacco use in the north, find their origins in the diffusion phenomena of the 18th and 19th century. Behavioral evolution governed the process of substance integration and was determinant for the continuity of use of these substances over a long period of time.

Published
2021

48. Impact of socio-economic traditions on current tobacco and tea addictions (Siberia 17th to 20th century)

Author

Macé, Matthias, primary, Richeval, Camille, additional, Romanova, Liubomira, additional, Gérard, Patrice, additional, Duchesne, Sylvie, additional, Cannet, Catherine, additional, Boyarskikh, Irina, additional, Gérault, Annie, additional, Zvénigorosky, Vincent, additional, Nikolaeva, Darya, additional, Stepanoff, Charles, additional, Allorge, Delphine, additional, Debrenne, Michele, additional, Ludes, Bertrand, additional, Alexeev, Anatoly, additional, Gaulier, Jean-Michel, additional, and Crubézy, Eric, additional

Published
2021
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