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23. Children Learning Through Science: A Progress Report.

Author

Richards, Roy

Abstract

Outlined is how the latest national curriculum project in science is tackling the lack of effective policies at school, local authority and national levels, and a lack of carefully conceived pupil material which is appropriately challenging both to the child and non-specialist primary or middle school teacher. (Author/KC)

Published
1980

26. Modeling the interactions of particulates with epithelial lining fluid antioxidants

Author

ZIELINSKI, HENRYK, MUDWAY, IAN S., BERUBE, KELLY A., MURPHY, SAMANTHA, RICHARDS, ROY, and KELLY, FRANK J.

Subjects
Epithelium -- Research, Oxidation, Physiological -- Research, Vitamin C -- Physiological aspects, Biological sciences
Abstract

Zielinski, Henryk, Ian S. Mudway, Kelly A. Berube, Samantha Murphy, Roy Richards, and Frank J. Kelly. Modeling the interactions of particulates with epithelial lining fluid antioxidants. Am. J. Physiol. 277 (Lung Cell. Mol. Physiol. 21): L719-L726, 1999.--Oxidative stress may be a fundamental mode of injury associated with inspired particles. To examine this, we determined the ability of three carbon black particles (CBPs; M120, M880, and R250) and two forms of silicon dioxide, amorphous (Cabosil) and crystalline (DQ12) quartz, to deplete epithelium lining fluid antioxidant defenses. Single and composite antioxidant solutions of uric acid, ascorbic acid (AA), and reduced glutathione (GSH) were examined in the presence of particle concentrations of 150 [micro]g/ml. Uric acid was not depleted by any particle considered. AA was depleted in a near-linear fashion with time by the three different CBPs; however, AA depletion rates varied markedly with CBP type and decreased in the presence of metal chelators. An initially high GSH depletion rate was noted with all CBPs, and this was always accompanied by the appearance of oxidized glutathione. Exposure to Cabosil or DQ12 did not result in the loss of GSH. Together, these data demonstrate that particle type, size, and surface area are all important factors when considering particle-antioxidant interactions in the airways. oxidative stress; particles; air pollution; ascorbic acid; reduced glutathione

Published
1999

35. Foreword

Author

Richards, Roy

Published
1990

41. First Contact.

Author

David, Paul, Pyke, Gary, Eatherton, Paul, Mancini, Gary, Castanho, Ana, Hamilton, Fiona Jane, Porter, John, Collin, Amanda, Lowndes, Belle Alice, Field, Natasha, Anne, Marisa, Richards, Roy, Sinha, Tushar, Kennedy, Nathan Paul, Bayne, Ryan R., Oxbrow, Craig, Tudor, Keith, Banks, Helen, Baker, Paul, and Roche, Jonah

Published
2018

46. In Vitro Tests for Respiratory Toxicity

Author

Lambré, Claude R., primary, Aufderheide, Michaela, additional, Bolton, Robert E., additional, Fubini, Bice, additional, Haagsman, Henk P., additional, Hext, Paul M., additional, Jorissen, Mark, additional, Landry, Yves, additional, Morin, Jean-Paul, additional, Nemery, Benoit, additional, Nettesheim, Paul, additional, Pauluhn, Jürgen, additional, Richards, Roy J., additional, Vickers, Alison E.M., additional, and Wu, Reen, additional

Published
1996
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