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Your search keyword '"Richards, Mark I. A."' showing total 22 results
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22 results on '"Richards, Mark I. A."'

1. In Vitro Activity of Novel Topoisomerase Inhibitors against Francisella tularensis and Burkholderia pseudomallei

Author

Whelan, Adam O., primary, Cooper, Ian, additional, Ooi, Nicola, additional, Orr, David, additional, Blades, Kevin, additional, Kirkham, James, additional, Lyons, Amanda, additional, Barnes, Kay B., additional, Richards, Mark I., additional, Salisbury, Anne-Marie, additional, Craighead, Mark, additional, and Harding, Sarah V., additional

Published
2023
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4. An Investigation into the Re-Emergence of Disease Following Cessation of Antibiotic Treatment in Balb/c Mice Infected with Inhalational Burkholderia pseudomallei

Author

Laws, Thomas R., primary, Barnes, Kay B., additional, Jenner, Dominic C., additional, Núñez, Alejandro, additional, Richards, Mark I., additional, Thwaite, Joanne E., additional, Vente, Andreas, additional, Rushton, David, additional, Nelson, Michelle, additional, and Harding, Sarah V., additional

Published
2022
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14. Simulation of greenhouse gases following land-use change to bioenergy crops using the ECOSSE model: a comparison between site measurements and model predictions

Author

Dondini, Marta, Richards, Mark I. A., Pogson, Mark, Mccalmont, Jon, Drewer, Julia, Marshall, Rachel, Morrison, Ross, Yamulki, Sirwan, Harris, Zoe M., Alberti, Giorgio, Siebicke, Lukas, Taylor, Gail, Perks, Mike, Finch, Jon, Mcnamara, Niall P., Smith, Joanne U., and Pete Smith

Subjects
land-use change, ECOSSE model, short rotation forestry, Agriculture and Soil Science, short rotation coppice, greenhouse gases, Miscanthus, ECOSSE model, energy crops, greenhouse gases, land-use change, Miscanthus, short rotation coppice, short rotation forestry, energy crops
Abstract

This paper evaluates the suitability of the ECOSSE model to estimate soil greenhouse gas fluxes from short rotation coppice willow (SRC-Willow), short rotation forestry (SRF-Scots Pine) and Miscanthus after land-use change from conventional systems (grassland and arable). We simulate heterotrophic respiration (Rh), nitrous oxide (N2O) and methane (CH4) fluxes at four paired sites in the UK, and compare them to estimates of Rh derived from the ecosystem respiration estimated from eddy covariance (EC) and Rh estimated from chamber (IRGA) measurements, as well as direct measurements of N2O and CH4 fluxes.Significant association between modelled and EC-derived Rh was found under Miscanthus, with correlation coefficient (r) ranging between 0.54 and 0.70. Association between IRGA-derived Rh and modelled outputs was statistically significant at the Aberystwyth site (r = 0.64) but not significant at the Lincolnshire site (r = 0.29). At all SRC-Willow sites, significant association was found between modelled and measurement-derived Rh (0.44 ? r ? 0.77); significant error was found only for the EC-derived Rh at the Lincolnshire site. Significant association and no significant error were also found for SRF-Scots Pine and perennial grass. For the arable fields, the modelled CO2 correlated well just with the IRGA-derived Rh at one site (r = 0.75). No bias in the model was found at any site, regardless of the measurement type used for the model evaluation.Across all land-uses, fluxes of CH4 and N2O were shown to represent a small proportion of the total greenhouse gas balance; these fluxes have been modelled adequately on a monthly time-step. This study provides confidence in using ECOSSE for predicting the impacts of future land-use on greenhouse gas balance, at site level as well as at national level.

Published
2016
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18. Simulation of greenhouse gases following land-use change to bioenergy crops using the ECOSSE model.:a comparison between site measurements and model predictions

Author

Dondini, Marta, Richards, Mark I. A., Pogson, Mark, McCalmont, Jon, Drewer, Julia, Marshall, Rachel, Morrison, Ross, Yamulki, Sirwan, Harris, Zoe M., Alberti, Giorgio, Siebicke, Lukas, Taylor, Gail, Perks, Mike, Finch, Jon, McNamara, Niall, Smith, Joanne U., Smith, Pete, Dondini, Marta, Richards, Mark I. A., Pogson, Mark, McCalmont, Jon, Drewer, Julia, Marshall, Rachel, Morrison, Ross, Yamulki, Sirwan, Harris, Zoe M., Alberti, Giorgio, Siebicke, Lukas, Taylor, Gail, Perks, Mike, Finch, Jon, McNamara, Niall, Smith, Joanne U., and Smith, Pete

Abstract

This article evaluates the suitability of the ECOSSE model to estimate soil greenhouse gas (GHG) fluxes from short rotation coppice willow (SRC‐Willow), short rotation forestry (SRF‐Scots Pine) and Miscanthus after land‐use change from conventional systems (grassland and arable). We simulate heterotrophic respiration (Rh), nitrous oxide (N2O) and methane (CH4) fluxes at four paired sites in the UK and compare them to estimates of Rh derived from the ecosystem respiration estimated from eddy covariance (EC) and Rh estimated from chamber (IRGA) measurements, as well as direct measurements of N2O and CH4 fluxes. Significant association between modelled and EC‐derived Rh was found under Miscanthus, with correlation coefficient (r) ranging between 0.54 and 0.70. Association between IRGA‐derived Rh and modelled outputs was statistically significant at the Aberystwyth site (r = 0.64), but not significant at the Lincolnshire site (r = 0.29). At all SRC‐Willow sites, significant association was found between modelled and measurement‐derived Rh (0.44 ≤ r ≤ 0.77); significant error was found only for the EC‐derived Rh at the Lincolnshire site. Significant association and no significant error were also found for SRF‐Scots Pine and perennial grass. For the arable fields, the modelled CO2 correlated well just with the IRGA‐derived Rh at one site (r = 0.75). No bias in the model was found at any site, regardless of the measurement type used for the model evaluation. Across all land uses, fluxes of CH4 and N2O were shown to represent a small proportion of the total GHG balance; these fluxes have been modelled adequately on a monthly time‐step. This study provides confidence in using ECOSSE for predicting the impacts of future land use on GHG balance, at site level as well as at national level.

Published
2016

19. Establishing an In Vivo Imaging Capability in High-Containment

Author

Flick-Smith, Helen C., primary, Commander, Nicola J., additional, Scott, Andrew E., additional, Thomas, Richard J., additional, Brown, Mark A., additional, Richards, Mark I., additional, Scott, Joanne C., additional, Martin, Kevin R., additional, Harding, Sarah V., additional, and Atkins, Helen S., additional

Published
2016
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20. Simulation of greenhouse gases following land-use change to bioenergy crops using the ECOSSE model: a comparison between site measurements and model predictions

Author

Dondini, Marta, primary, Richards, Mark I. A., additional, Pogson, Mark, additional, McCalmont, Jon, additional, Drewer, Julia, additional, Marshall, Rachel, additional, Morrison, Ross, additional, Yamulki, Sirwan, additional, Harris, Zoe M., additional, Alberti, Giorgio, additional, Siebicke, Lukas, additional, Taylor, Gail, additional, Perks, Mike, additional, Finch, Jon, additional, McNamara, Niall P., additional, Smith, Joanne U., additional, and Smith, Pete, additional

Published
2015
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21. Establishing an In VivoImaging Capability in High-Containment

Author

Flick-Smith, Helen C., Commander, Nicola J., Scott, Andrew E., Thomas, Richard J., Brown, Mark A., Richards, Mark I., Scott, Joanne C., Martin, Kevin R., Harding, Sarah V., and Atkins, Helen S.

Abstract

Whole body imaging technologies, coupled with the generation of stable light emitting strains of infectious agents, make it possible to monitor the location and kinetics of agent growth inside an animal by noninvasive nonterminal methodologies throughout the course of the infection. However, imaging of viable hazardous pathogens, such as Yersinia pestis, requires specialized containment facilities to prevent contamination of both personnel and the wider environment. Here we describe the successful establishment of an in vivobioimaging capability specifically addressing the requirement for safe and secure work with hazard group 3 pathogens and demonstrate its utility for imaging mice infected with a bioluminescence producing strain of Y. pestis.

Published
2016
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22. Demonstration of the Broad-Spectrum In VitroActivity of Finafloxacin against Pathogens of Biodefense Interest

Author

Barnes, Kay B., Zumbrun, Steven D., Halasohoris, Stephanie A., Desai, Purvi D., Miller, Lynda L., Richards, Mark I., Russell, Paul, Bentley, Christine, and Harding, Sarah V.

Abstract

This study investigated the in vitroactivity of finafloxacin against bacterial strain panels of the biodefense pathogens. Broth microdilution assays were performed at neutral and acidic pH to determine the effectiveness of the antibiotics under conditions typical of an intracellular environment. In all instances, finafloxacin demonstrated superior activity at low pH.

Published
2019
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