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273 results on '"Richards, Elaine M."'

17. Identification of a Gut Commensal That Compromises the Blood Pressure-Lowering Effect of Ester Angiotensin-Converting Enzyme Inhibitors

Author

Yang, Tao, primary, Mei, Xue, additional, Tackie-Yarboi, Ethel, additional, Akere, Millicent Tambari, additional, Kyoung, Jun, additional, Mell, Blair, additional, Yeo, Ji-Youn, additional, Cheng, Xi, additional, Zubcevic, Jasenka, additional, Richards, Elaine M., additional, Pepine, Carl J., additional, Raizada, Mohan K., additional, Schiefer, Isaac T., additional, and Joe, Bina, additional

Published
2022
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18. Efficacy and Safety of MSC Cell Therapies for Hospitalized Patients with COVID-19: A Systematic Review and Meta-Analysis

Author

Qu, Wenchun, Wang, Zhen, Engelberg-Cook, Erica, Yan, Dan, Siddik, Abu Bakar, Bu, Guojun, Allickson, Julie G, Kubrova, Eva, Caplan, Arnold I, Hare, Joshua M, Ricordi, Camillo, Pepine, Carl J, Kurtzberg, Joanne, Pascual, Jorge M, Mallea, Jorge M, Rodriguez, Ricardo L, Nayfeh, Tarek, Saadi, Samer, Durvasula, Ravindra V, Richards, Elaine M, March, Keith, Sanfilippo, Fred P, Qu, Wenchun, Wang, Zhen, Engelberg-Cook, Erica, Yan, Dan, Siddik, Abu Bakar, Bu, Guojun, Allickson, Julie G, Kubrova, Eva, Caplan, Arnold I, Hare, Joshua M, Ricordi, Camillo, Pepine, Carl J, Kurtzberg, Joanne, Pascual, Jorge M, Mallea, Jorge M, Rodriguez, Ricardo L, Nayfeh, Tarek, Saadi, Samer, Durvasula, Ravindra V, Richards, Elaine M, March, Keith, and Sanfilippo, Fred P

Abstract

MSC (a.k.a. mesenchymal stem cell or medicinal signaling cell) cell therapies show promise in decreasing mortality in acute respiratory distress syndrome (ARDS) and suggest benefits in treatment of COVID-19-related ARDS. We performed a meta-Analysis of published trials assessing the efficacy and adverse events (AE) rates of MSC cell therapy in individuals hospitalized for COVID-19. Systematic searches were performed in multiple databases through November 3, 2021. Reports in all languages, including randomized clinical trials (RCTs), non-randomized interventional trials, and uncontrolled trials, were included. Random effects model was used to pool outcomes from RCTs and non-randomized interventional trials. Outcome measures included all-cause mortality, serious adverse events (SAEs), AEs, pulmonary function, laboratory, and imaging findings. A total of 736 patients were identified from 34 studies, which included 5 RCTs (n = 235), 7 non-randomized interventional trials (n = 370), and 22 uncontrolled comparative trials (n = 131). Patients aged on average 59.4 years and 32.2% were women. When compared with the control group, MSC cell therapy was associated with a reduction in all-cause mortality (RR = 0.54, 95% CI: 0.35-0.85, IâŠâŠ2 = 0.0%), reduction in SAEs (IRR = 0.36, 95% CI: 0.14-0.90, IâŠâŠ2 = 0.0%) and no significant difference in AE rate. A sub-group with pulmonary function studies suggested improvement in patients receiving MSC. These findings support the potential for MSC cell therapy to decrease all-cause mortality, reduce SAEs, and improve pulmonary function compared with conventional care. Large-scale double-blinded, well-powered RCTs should be conducted to further explore these results. © 2022 Published by Oxford University Press.

Published
2022

20. Efficacy and Safety of MSC Cell Therapies for Hospitalized Patients with COVID-19: A Systematic Review and Meta-Analysis

Author

Qu, Wenchun, primary, Wang, Zhen, additional, Engelberg-Cook, Erica, additional, Yan, Dan, additional, Siddik, Abu Bakar, additional, Bu, Guojun, additional, Allickson, Julie G, additional, Kubrova, Eva, additional, Caplan, Arnold I, additional, Hare, Joshua M, additional, Ricordi, Camillo, additional, Pepine, Carl J, additional, Kurtzberg, Joanne, additional, Pascual, Jorge M, additional, Mallea, Jorge M, additional, Rodriguez, Ricardo L, additional, Nayfeh, Tarek, additional, Saadi, Samer, additional, Durvasula, Ravindra V, additional, Richards, Elaine M, additional, March, Keith, additional, and Sanfilippo, Fred P, additional

Published
2022
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22. Gut commensal Coprococcus comes diminishes the blood pressure‐lowering effect of ester angiotensin‐converting enzyme inhibitors

Author

Yang, Tao, primary, Mei, Xue, additional, Tackie‐Yarbo, Ethel, additional, Tambari Akere, Millicent, additional, Kyoung, Jun, additional, Mell, Blair, additional, Yeo, Ji‐Youn, additional, Cheng, Xi, additional, Zubcevic, Jasenka, additional, Richards, Elaine M., additional, Pepine, Carl J., additional, Raizada, Mohan K., additional, Schiefer, Isaac T., additional, and Joe, Bina, additional

Published
2022
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30. Effectiveness and Safety of MSC Cell Therapies for Hospitalized Patients with COVID-19: A Systematic Review and Meta-analysis

Author

Qu, Wenchun, primary, Wang, Zhen, additional, Engelberg-Cook, Erica, additional, Siddik, Abu Bakar, additional, Bu, Guojun, additional, Allickson, Julie G., additional, Kubrova, Eva, additional, Caplan, Arnold I., additional, Hare, Joshua M., additional, Ricordi, Camillo, additional, Pepine, Carl J., additional, Kurtzberg, Joanne, additional, Pascual, Jorge M., additional, Mallea, Jorge M., additional, Rodriguez, Ricardo L., additional, Nayfeh, Tarek, additional, Saadi, Samer, additional, Richards, Elaine M., additional, March, Keith, additional, and Sanfilippo, Fred P., additional

Published
2021
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31. Abstract MP38: Identification Of A Gut Microbe That Attenuates The Blood Pressure Lowering Effect Of ACEi Quinapril

Author

Yang, Tao, primary, Mei, Xue, additional, Tackie-Yarboi, Ethel, additional, Kyoung, Jun, additional, Mell, Blair, additional, Yeo, Ji-Youn, additional, Cheng, Xi, additional, Zubcevic, Jasenka, additional, Richards, Elaine M, additional, Pepine, Carl J, additional, Raizada, Mohan K, additional, Schiefer, Isaac T, additional, and Joe, Bina, additional

Published
2021
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32. Expression of ENaC subunits, chloride channels, and aquaporins in ovine fetal lung: ontogeny of expression and effects of altered fetal cortisol concentrations

Author

Jesse, Nathan M., McCartney, Jarret, Feng, Xiaodi, Richards, Elaine M., Wood, Charles E., and Keller-Wood, Maureen

Subjects
Aquaporins -- Physiological aspects, Aquaporins -- Genetic aspects, Aquaporins -- Research, Gene expression -- Research, Lung diseases -- Genetic aspects, Lung diseases -- Control, Lung diseases -- Research, Messenger RNA -- Physiological aspects, Messenger RNA -- Research, Sodium channels -- Physiological aspects, Sodium channels -- Genetic aspects, Sodium channels -- Research, Biological sciences
Abstract

Jesse NM, McCartney J, Feng X, Richards EM, Wood CE, Keller-Wood M. Expression of ENaC subunits, chloride channels, and aquaporins in ovine fetal lung: ontogeny of expression and effects of altered fetal cortisol concentrations. Am J Physiol Regul Integr Comp Physiol 297: R453-R461, 2009. First published June 10, 2009; doi:10.1152/ajpregu.00127.2009. Transition of the epithelium of the fetal lung from fluid secretion to fluid reabsorption requires changes in the expression of ion channels. Corticosteroids regulate expression of several of these channels, including the epithelium sodium channel (ENaC) subunits and aquaporins (AQP). We investigated the ontogenetic changes in these ion channels in the ovine fetal lung during the last half of gestation, a time of increasing adrenal maturation. Expression of the mRNAs for the chloride channels, cystic fibrosis transmembrane conductance regulator (CVTR), and chloride channel 2 (CLCN2) decreased with age. Expression of mRNAs for AQP1, AQP5, and for subunits of ENaC ([alpha], [beta], [gamma]) increased with age. In the fetal sheep the expression of ENaC[beta] mRNA was dramatically higher than the expression of ENaC[alpha] or ENaC[gamma], but expression of ENaC[beta] protein decreased with maturation, although the ratio of the mature (112 kDa) to immature (102 kDa) ENaC[beta] protein increased with age, particularly in the membrane fraction. In contrast, ENaC[alpha] mRNA and protein both increase with maturation, and the mature form of ENaC[alpha] (68 kDa) predominates at all ages. A modest increase in fetal cortisol, within the range expected to occur naturally in late gestation but prior to active labor, increased ENaC[alpha] mRNA but not ENaC[beta], ENAC[gamma], or AQP mRNAs. We conclude that in the ovine fetal lung, appearance of functional sodium channels is associated with induction of ENAC[alpha] and ENaC[gamma], and that ENaC[alpha] expression may be induced by even small, preterm increases in fetal cortisol. fetus; sodium channel; cortisol; lung maturation

Published
2009

45. Angiotensin II increases glucose uptake and glucose transporter-1 mRNA levels in astroglia

Author

Tang, Wei, Richards, Elaine M., Raizada, Mohan K., and Sumners, Colin

Subjects
Angiotensin -- Receptors, Glucose -- Physiological aspects, Protein kinases -- Research, Biological sciences
Abstract

The study of the effects of angiotensin II (ANG II) on glucose intake into astroglia reveals that ANG II enhances glucose intake into astroglia. The astroglia for this study is cultured from adult rat hypothalamus and brain stem. The process of enhancement occurs through the pathway which is associated with the AT1 receptors.

Published
1995

46. Modulation of the delayed rectifier K+ current in neurons by an angiotensin II type 2 receptor fragment

Author

Kang, Jian, Richards, Elaine M., Posner, Philip, and Sumners, Colin

Subjects
Potassium channels -- Research, Neurons -- Physiological aspects, Angiotensin -- Receptors, Biological sciences
Abstract

Analysis of receptor-G protein coupling processes in rat brain stem and hypothalamus by injecting a 22-amino acid peptide (PEP-22) that corresponds to the third intracellular loop of cloned AT2 receptor shows that PEP-22 induces an increase in rectifier K+ current in the neurons, this effect being similar to effect of angiotensin II (ANG II). Superfusion of PP2A inhibitor okadaic acid and treatment with pertussis toxin suppress the effect of PEP-22, indicating that PP2A and Gi proteins contribute to the PEP-22-induced effect, respectively. The third intracellular loop of AT2 receptor is vital for ANG II-induced activation of neuronal K+ current.

Published
1995

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