Search

Aim To establish the inter-rater reliability of the Composite Quality Score (CQS)-2 and to test the null hypothesis that it did not differ significantly from that of the first CQS version (CQS-1). Materials and methods Four independent raters from three countries were selected to rate 45 clinical trial reports using CQS-1 and CQS-2. The raters remained unaware of each other’s participation in this study until all rating had been completed. Each rater received only one rating template at a time in a random sequence for CQS-1 and CQS-2 rating. Raters completed each template and sent these back to the principal investigator. Each rater received their next template two weeks after submission of the completed previous template. The inter-rater reliabilities for the overall appraisal score of the CQS-1 and the CQS-2 were established by using the Brennan-Prediger coefficient (BPC). The coefficients of both CQS versions were compared by using the two-sample z-test. During secondary analysis, the BPCs for every criterion and each corroboration level for both CQS versions were established. Results The BPC for the CQS-1 was 0.85 (95% CI: 0.64–1.00) and for the CQS-2 it was 1.00 (95% CI: 0.94–1.00), suggesting a very high inter-rater reliability for both. The difference between the two CQS versions was statistically not significant (p = 0.17). The null hypothesis was accepted. Conclusion This study shows that the CQS-2 is associated with a very high inter-rater reliability, which did not statistically significantly differ from that of the CQS-1. The promising results of this study warrant further investigation in the applicability of the CQS-2 as an appraisal tool for prospective controlled clinical therapy trials.

Introduction: The aim of the study was two evaluate the effectiveness of a Peyton teaching approach for rotary root canal instrumentation, in comparison to the traditional “see one–do one” method. Material and Methods: Forty undergraduate students were randomly divided into two groups (n = 20). Students of the first group (G1) were taught how to use rotary instrumentation using a modified Peyton method, whilst the second group (G2) watched a teaching video (30 min) on the same subject. Both groups instrumented a plastic block and subsequently both mesial canals of an extracted lower molar. The quality of the root canal instrumentation was analysed by 2 blinded observers on video recordings and x-rays. Results: Interobserver correlation was 0.917 (p

(1) Background: Due to advantages such as avoidance of chipping, pulp-friendly tooth preparation and cost reduction, zirconia is increasingly being used monolithically without veneering. Nevertheless, to enable good aesthetics, various multilayer systems have been developed. The aim of this study was to investigate the impact of different zirconia multilayer strategies and yttria levels on fracture load, fracture pattern, stress distribution and surface roughness. (2) Methods: Monolithic three-unit anterior FDPs were made from three different color-gradient zirconia multilayer materials with different yttria levels corresponding to varying strength and degrees of translucency grades (Katana HTML, STML, UTML, Kuraray) and one strength-gradient zirconia multilayer material (Katana YML, Kuraray) and artificially aged in a chewing simulator (1.2 × 106 load cycles, 50 N, 2 × 3000 thermocycles, 5–55 °C). Analyses of fracture load, fracture pattern, fracture surfaces, stress distribution and roughness were performed after the fracture load test. Shapiro–Wilk, Kruskal–Wallis, Mann–Whitney U-tests and one-way ANOVA were used (p < 0.05). (3) Results: Fracture loads of the high strength color-gradient material HTML and the strength-gradient material YML were comparable after 5 years of aging (p = 0.645). Increasing yttria levels resulted in a decrease in fracture resistance of 42–57% (p < 0.05). Surface roughness of different zirconia generations is comparable after polishing and aging. (4) Conclusions: Color-gradient multilayer zirconia materials and new strength-gradient zirconia materials with similar yttria levels in the basal layers show comparable mechanical properties and are suitable for anterior FDPs.

To compare the intraocular pressure (IOP)-lowering efficacy and safety of netarsudil once daily (QD) and timolol twice daily (BID).Double-masked, randomized, phase 3, noninferiority study.Patients with open-angle glaucoma or ocular hypertension (unmedicated baseline IOP20 to30 mm Hg at 8:00 AM) were randomized to netarsudil ophthalmic solution 0.02% QD (PM) or timolol ophthalmic solution 0.5% BID. The primary endpoint was mean IOP at 8:00 AM, 10:00 AM, and 4:00 PM at week 2, week 6, and month 3 in patients with baseline IOP25 mm Hg (per-protocol population). Safety was recorded over the 6-month treatment period.A total of 186 patients from each treatment arm were included in the primary efficacy analysis. Netarsudil QD met the criteria for noninferiority to timolol BID. Mean treated IOP ranged from 16.3 to 17.9 mm Hg for netarsudil and 16.7 to 17.6 for timolol, with mean reductions from baseline of 3.9 to 4.7 mm Hg and 3.8 to 5.2 mm Hg, respectively. In prespecified secondary analyses, netarsudil demonstrated noninferiority to timolol in patients with baseline IOP27 mm Hg and30 mm Hg. The IOP-lowering effects of netarsudil were sustained over 6 months of treatment. No treatment-related serious adverse event (AE) was reported for either study drug. However, statistically significant reductions in mean heart rate were recorded at all study visits for the timolol group. The most frequent ocular AE among netarsudil-treated patients was conjunctival hyperemia (47.9%), which was predominately mild.Netarsudil QD (PM), a first-in-class IOP-lowering medication, was noninferior to timolol BID and was associated with tolerable ocular AEs.

The aim of this study was to assess the fatigue loading behavior and fracture resistance of endodontically treated teeth restored with adhesively luted bundled fiber posts in comparison to solid fiber posts. Image analysis (2D and 3D) was applied to evaluate modes of failure and to characterize susceptible parts of the post-and-core interface.Crowns of 72 human similar-sized central upper incisors were removed and roots received a conventional root canal filling prior to establishing 4 groups of core build-up: No Post group (nP) received a 4 mm deep filling made of composite inside the canal with no dental post, fiber post group (FP) received a conventional solid post, and two experimental groups received bundles of 6 (FB6) or 12 (FB12) 0.3 mm thin fiber posts, respectively. Posts were placed adhesively inside the root canal using a dual-curing build-up composite in combination with a self-etch adhesive, the latter was also used for nP group. Upon completion of core build-ups, all teeth received full-ceramic crowns that recreated the original tooth form. Samples were subjected in a 135° angle to thermo-mechanical loading (TML) for 1.2 Mill. chewing cycles followed by static load tests (fracture resistance). Fracture modes as well as intracanal failure modes with respect to failed interfaces were analyzed using optical and electron microscopy (SEM). Microcomputer tomography (μCT) was used to exemplary compare pre and post TML geometries.Static load test was significantly different between groups (p 0.0005; Kruskal-Wallistest). Pairwise comparison showed that the nP group (221 ± 103N) failed at significantly lower forces compared to the FP (454 ± 184N), FB6 (477 ± 250N) and FB12 (478 ± 260N) groups (p ≤ 0,001; Mann-Whitney-U-test). Fracture modes were significantly affected by the presence or absence of a post (p ≤ 0,016; Chi-square test) revealing increased incidence of restorable fractures at the cervical region for nP group. Microscopic analysis revealed more intracanal failures at interfaces between post surfaces and composite for solid posts, whereas fiber bundled posts mostly failed at the interfaces between composite and dentin. Micro-CT analysis showed no alterations of the root-post-and-core structure after TML except slight deformations of occasionally entrapped voids.Fracture resistance and fracture modes were significantly affected by the presence or absence of a post, whereas the investigated post groups did not differ from each other. However intracanal failure revealed differences in adhesive failures between solid fiber posts and bundled fiber posts. Deformations of entrapped voids, revealed by micro-Ct analyses after TML, lead to the assumption that applied forces result in alterations in the regions of voids.

The aim of the present study was to measure the bond strength of adhesively luted glass-fiber bundles inside the root canal with respect to the application procedure in comparison to conventional solid glass-fiber posts.104 human anterior teeth were endodontically treated, root filled and divided into 8 groups (n = 13). After post space preparation, fiber bundles consisting of 6 and 12 glass fibers, respectively, were luted adhesively with a multi-mode adhesive (Futurabond U; Voco, Cuxhaven, Germany) and a dual-curing composite (Rebilda DC, Voco) with the following application modes into the root canal: (1) direct application with tweezers, (2) distribution of the fibers using a spreader, (3) application of ultrasound after insertion of fibers. Two different solid posts (Rebilda DC, Voco; and DentinPost, Komet, Lemgo, Germany) were used as controls. Roots were sectioned into 6 slices per root (thickness 1 mm). Bond strengths were measured using thin-slice push-out tests for 3 slices 24 h after post insertion and for 3 slices per sample following thermocycling (TC) for 6000 cycles and storage in 0.9% NaCl for 6 months. Homogeneity of the slices was analyzed using a stereomicroscope and, for representative samples, micro-computed tomography (µCT).Mean push-out bond strengths (MPa) were significantly affected by post system (p0.0005) and location inside the root canal (p = 0.004) but not by application mode (p = 0.544) or TC (p = 0.098; repeated measurement ANOVA). Fiber bundles consisting of 6 (13.2 ± 4.7) and 12 fibers (14.5 ± 4.3) revealed bond strength comparable to that of Rebilda Post (13.67 ± 3.2) but significantly higher than that of Dentin Posts (8.7 ± 3.02). Inhomogeneities were detected among 35.5% to 43.1% of the fiber-bundle samples, irrespective of number of fibers and application mode, and among 24.4% to 27.3% of the solid posts (p = 0.010; chi-squared test). µCT revealed voids inside the composite bulk between the fibers as well as between composite and dentin of adhesively luted fiber bundles.Adhesively luted fiber bundles achieved bond strengths comparable to those of solid fiber posts for one investigated post type, and even higher values compared to another post type. Inhomogeneities were frequently detected irrespective of application mode.

The X-ray binary population of the Small Magellanic Cloud (SMC) contains a large number of massive X-ray binaries and the recent survey of the SMC by XMM-Newton has resulted in almost 50 more tentative high mass X-ray binary candidates. Using probability parameters from Haberl & Sturm (2016) together with the optical spectra and timing in this work, we confirm six new massive X-ray binaries in the SMC. We also report two very probable binary periods; of 36.4d in XMM 1859 and of 72.2 d in XMM 2300. These Be X-ray binaries are likely part of the general SMC population which rarely undergoes an X-ray outburst., 6 pages, 3 figures, accepted for publication in MNRAS

Context. About 120 Be/X-ray binaries (BeXBs) are known in the Small Magellanic Cloud (SMC); about half of them are pulsating with periods from a few to hundreds of seconds. SXP 1323 is one of the longest-period pulsars known in this galaxy. Aims. SXP 1323 is in the field of view of a large set of calibration observations that we analyse systematically, focusing on the time analysis, in search of periodic signals. Methods. We analyse all available X-ray observations of SXP 1323 from Suzaku, XMM-Newton, and Chandra, in the time range from 1999 to the end of 2016. We perform a Lomb-Scargle periodogram search in the band 2.5-10 keV on all observations to detect the neutron star spin period and constrain its long-term evolution. We also perform an orbital period search on the long-term light curve, merging all datasets. Results. We report the discovery of a 26.188+-0.045 d period analysing data from Suzaku, XMM-Newton, and Chandra, which confirms the optical period derived from the Optical Gravitational Lensing Experiment (OGLE) data. If this corresponds to the orbital period, this would be very short with respect to what is expected from the spin/orbital period relationship. We furthermore report on the spin period evolution in the last years. The source is spinning-up with an average rate of Pdot/P of 0.018 yr-1, decreasing from 1340 to 1100 s, in the period from 2006 to the end of 2016, which is also extreme with respect to the other Be/X-ray pulsars. From 2010 to the end of 2014, the pulse period is not clearly detectable, although the source was still bright. Conclusions. SXP 1323 is a peculiar BeXB due to its long pulse period, rapid spin-up for several years, and short orbital period. A continuous monitoring of the source in the next years is necessary to establish the long-term behaviour of the spin period., 10 pages, 4 figures, 3 tables

We present a detailed radio, X-ray and optical study of a newly discovered Large Magellanic Cloud (LMC) supernova remnant (SNR) which we denote MCSNR J0508-6902. Observations from the Australian Telescope Compact Array (ATCA) and the $\textit{XMM-Newton}$ X-ray observatory are complemented by deep H$\alpha$ images and Anglo Australian Telescope AAOmega spectroscopic data to study the SNR shell and its shock-ionisation. Archival data at other wavelengths are also examined. The remnant follows a filled-in shell type morphology in the radio-continuum and has a size of $\sim$74 pc $\times$ 57 pc at the LMC distance. The X-ray emission exhibits a faint soft shell morphology with Fe-rich gas in its interior $-$ indicative of a Type Ia origin. The remnant appears to be mostly dissipated at higher radio-continuum frequencies leaving only the south-eastern limb fully detectable while in the optical it is the western side of the SNR shell that is clearly detected. The best-fit temperature to the shell X-ray emission ($kT = 0.41^{+0.05}_{-0.06}$ keV) is consistent with other large LMC SNRs. We determined an O/Fe ratio of $

Recent X-ray emission events in the Galactic center would be expected to generate an X-ray reflection response within the surrounding clouds of the central molecular zone, in the Galactic disk and even, if powerful enough, in clouds outside our Galaxy. We review here the current constraints on Sgr A*'s past activity obtained through this method, with particular emphasis on the strong evidence that has been gathered for multiple X-ray flashes during the past few hundred years.

Thanks to the large collecting area (3 x ~1500 cm$^2$ at 1.5 keV) and wide field of view (30' across in full field mode) of the X-ray cameras on board the European Space Agency X-ray observatory XMM-Newton, each individual pointing can result in the detection of hundreds of X-ray sources, most of which are newly discovered. Recently, many improvements in the XMM-Newton data reduction algorithms have been made. These include enhanced source characterisation and reduced spurious source detections, refined astrometric precision, greater net sensitivity and the extraction of spectra and time series for fainter sources, with better signal-to-noise. Further, almost 50\% more observations are in the public domain compared to 2XMMi-DR3, allowing the XMM-Newton Survey Science Centre (XMM-SSC) to produce a much larger and better quality X-ray source catalogue. The XMM-SSC has developed a pipeline to reduce the XMM-Newton data automatically and using improved calibration a new catalogue version has been produced from XMM-Newton data made public by 2013 Dec. 31 (13 years of data). Manual screening ensures the highest data quality. This catalogue is known as 3XMM. In the latest release, 3XMM-DR5, there are 565962 X-ray detections comprising 396910 unique X-ray sources. For the 133000 brightest sources, spectra and lightcurves are provided. For all detections, the positions on the sky, a measure of the quality of the detection, and an evaluation of the X-ray variability is provided, along with the fluxes and count rates in 7 X-ray energy bands, the total 0.2-12 keV band counts, and four hardness ratios. To identify the detections, a cross correlation with 228 catalogues is also provided for each X-ray detection. 3XMM-DR5 is the largest X-ray source catalogue ever produced. Thanks to the large array of data products, it is an excellent resource in which to find new and extreme objects., Comment: 23 pages, version accepted for publication in A&A

We report on the results of a $\sim$40 d multi-wavelength monitoring of the Be X-ray binary system IGR J05007-7047 (LXP 38.55). During that period the system was monitored in the X-rays using the Swift telescope and in the optical with multiple instruments. When the X-ray luminosity exceeded $10^{36}$ erg/s we triggered an XMM-Newton ToO observation. Timing analysis of the photon events collected during the XMM-Newton observation reveals coherent X-ray pulsations with a period of 38.551(3) s (1 {\sigma}), making it the 17$^{th}$ known high-mass X-ray binary pulsar in the LMC. During the outburst, the X-ray spectrum is fitted best with a model composed of an absorbed power law ($\Gamma =0.63$) plus a high-temperature black-body (kT $\sim$ 2 keV) component. By analysing $\sim$12 yr of available OGLE optical data we derived a 30.776(5) d optical period, confirming the previously reported X-ray period of the system as its orbital period. During our X-ray monitoring the system showed limited optical variability while its IR flux varied in phase with the X-ray luminosity, which implies the presence of a disk-like component adding cooler light to the spectral energy distribution of the system., Comment: 11 pages, 11 figures, Accepted for publication in MNRAS

In the course of the XMM-Newton survey of the Small Magellanic Cloud (SMC), two new bright X-ray sources were discovered exhibiting the spectral characteris- tics of High Mass X-ray Binaries - but revealing only weak evidence for pulsations in just one of the objects(at 153s in XMMUJ010743.1-715953). The accurate X- ray source locations permit the identification of these X-ray source with Be stars, thereby strongly suggesting these systems are new Be/X-ray binaries. From blue spectra the proposed classification for XMMUJ010633.1-731543 is B0.5-1Ve and for XMMUJ010743.1-715953 it is B2IV-Ve.

In the course of the XMM-Newton survey of the Small Magellanic Cloud (SMC), a region to the east of the emission nebula N19 was observed in November 2009. To search for new candidates for high mass X-ray binaries the EPIC PN and MOS data of the detected point sources were investigated and their spectral and temporal characteristics identified. A new transient (XMMUJ005011.2-730026= SXP214) with a pulse period of 214.05 s was discovered; the source had a hard X-ray spectrum with power-law index of ~0.65. The accurate X-ray source location permits the identification of the X-ray source with a ~15th magnitude Be star, thereby confirming this system as a new Be/X-ray binary.

We report on Suzaku observations of SN 1987 A in the Large Magellanic Cloud, performed in 2005 November and 2006 June. The observations provide medium resolution X-ray spectra during the phase of the interaction between the supernova blast wave and the inner circumstellar ring. The Suzaku observations complement XMM-Newton and Chandra observations and were used to investigate the spectral evolution of SN 1987 A. The spectra were analyzed with two-temperature emission model from shocked gas. For the flux in the soft band (0.5– 2.0 keV) we obtained 25.7 1:9 10 13 erg cm 2 (2005) and 30.8 1:7 10 13 erg cm 2 (2006). The exponential rise seen in the soft X-ray light curve of SN 1987 A till 6500 d after the explosion slowed down significantly between the Suzaku observations. Recent Chandra and XMM-Newton observations confirm this evolution. SN 1987 A continues to brighten exponentially, but with longer characteristic timescale. This must be caused by a less rapidly increasing emission measure.

The last comprehensive catalogue of high-mass X-ray binaries in the Small Magellanic Cloud (SMC) was published about ten years ago. Since then new such systems were discovered, mainly by X-ray observations with Chandra and XMM-Newton. For the majority of the proposed HMXBs in the SMC no X-ray pulsations were discovered as yet, and unless other properties of the X-ray source and/or the optical counterpart confirm their HMXB nature, they remain only candidate HMXBs. From a literature search we collected a catalogue of 148 confirmed and candidate HMXBs in the SMC and investigated their properties to shed light on their real nature. Based on the sample of well-established HMXBs (the pulsars), we investigated which observed properties are most appropriate for a reliable classification. We defined different levels of confidence for a genuine HMXB based on spectral and temporal characteristics of the X-ray sources and colour-magnitude diagrams from the optical to the infrared of their likely counterparts. We also took the uncertainty in the X-ray position into account. We identify 27 objects that probably are misidentified because they lack an infrared excess of the proposed counterpart. They were mainly X-ray sources with a large positional uncertainty. This is supported by additional information obtained from more recent observations. Our catalogue comprises 121 relatively high-confidence HMXBs (the vast majority with Be companion stars). About half of the objects show X-ray pulsations, while for the rest no pulsations are known as yet. A comparison of the two subsamples suggests that long pulse periods in excess of a few 100 s are expected for the "non-pulsars", which are most likely undetected because of aperiodic variability on similar timescales and insufficiently long X-ray observations. (abbreviated), 17 pages, 9 figures, accepted for publication in Astronomy & Astrophysics, new version after language editing and minor changes

The deepest XMM-Newton mosaic map of the central 1.5 deg of the Galaxy is presented, including a total of about 1.5 Ms of EPIC-pn cleaned exposures in the central 15" and about 200 ks outside. This compendium presents broad-band X-ray continuum maps, soft X-ray intensity maps, a decomposition into spectral components and a comparison of the X-ray maps with emission at other wavelengths. Newly-discovered extended features, such as supernova remnants (SNRs), superbubbles and X-ray filaments are reported. We provide an atlas of extended features within +-1 degree of Sgr A*. We discover the presence of a coherent X-ray emitting region peaking around G0.1-0.1 and surrounded by the ring of cold, mid-IR-emitting material known from previous work as the "Radio Arc Bubble" and with the addition of the X-ray data now appears to be a candidate superbubble. Sgr A's bipolar lobes show sharp edges, suggesting that they could be the remnant, collimated by the circumnuclear disc, of a SN explosion that created the recently discovered magnetar, SGR J1745-2900. Soft X-ray features, most probably from SNRs, are observed to fill holes in the dust distribution, and to indicate a direct interaction between SN explosions and Galactic center (GC) molecular clouds. We also discover warm plasma at high Galactic latitude, showing a sharp edge to its distribution that correlates with the location of known radio/mid-IR features such as the "GC Lobe". These features might be associated with an inhomogeneous hot "atmosphere" over the GC, perhaps fed by continuous or episodic outflows of mass and energy from the GC region., Comment: MNRAS published online. See www.mpe.mpg.de/heg/gc/ for a higher resolution version of the figures

We identify a new candidate for a Be/X-ray binary in the XMM-Newton slew survey and archival Swift observations that is located in the transition region of the Wing of the Small Magellanic Cloud and the Magellanic Bridge. We investigated and classified this source with follow-up XMM-Newton and optical observations. We model the X-ray spectra and search for periodicities and variability in the X-ray observations and the OGLE I-band light curve. The optical counterpart has been classified spectroscopically, with data obtained at the SAAO 1.9 m telescope, and photometrically, with data obtained using GROND at the MPG 2.2 m telescope. The X-ray spectrum is typical of a high-mass X-ray binary with an accreting neutron star. We detect X-ray pulsations, which reveal a neutron-star spin period of P = (264.516+-0.014) s. The source likely shows a persistent X-ray luminosity of a few 10^35 erg/s and in addition type-I outbursts that indicate an orbital period of ~146 d. A periodicity of 0.867 d, found in the optical light curve, can be explained by non-radial pulsations of the Be star. We identify the optical counterpart and classify it as a B1-2II-IVe star. This confirms SXP 265 as a new Be/X-ray binary pulsar originating in the tidal structure between the Magellanic Clouds., 11 pages, 12 figures, accepted for publication in MNRAS

Local-Group galaxies provide access to samples of X-ray source populations of whole galaxies. The XMM-Newton survey of the Small Magellanic Cloud (SMC) completely covers the bar and eastern wing with a 5.6 deg^2 area in the (0.2-12.0) keV band. To characterise the X-ray sources in the SMC field, we created a catalogue of point sources and sources with moderate extent. Sources with high extent (>40") have been presented in a companion paper. We searched for point sources in the EPIC images using sliding-box and maximum-likelihood techniques and classified the sources using hardness ratios, X-ray variability, and their multi-wavelength properties. The catalogue comprises 3053 unique X-ray sources with a median position uncertainty of 1.3" down to a flux limit for point sources of ~10^-14 erg cm^-2 s^-1 in the (0.2-4.5) keV band, corresponding to 5x10^33 erg s^-1 for sources in the SMC. We discuss statistical properties, like the spatial distribution, X-ray colour diagrams, luminosity functions, and time variability. We identified 49 SMC high-mass X-ray binaries (HMXB), four super-soft X-ray sources (SSS), 34 foreground stars, and 72 active galactic nuclei (AGN) behind the SMC. In addition, we found candidates for SMC HMXBs (45) and faint SSSs (8) as well as AGN (2092) and galaxy clusters (13). We present the most up-to-date catalogue of the X-ray source population in the SMC field. In particular, the known population of X-ray binaries is greatly increased. We find that the bright-end slope of the luminosity function of Be/X-ray binaries significantly deviates from the expected universal high-mass X-ray binary luminosity function., 32 pages, 18 figures, accepted for publication in A&A, catalog will be available at CDS

We report the discovery of LXP169, a new high-mass X-ray binary (XRB) in the LMC. The optical counterpart has been identified and appears to exhibit an eclipsing light curve. We performed follow-up observations to clarify the eclipsing nature of the system. Energy spectra and time series were extracted from two XMM-Newton observations to search for pulsations, characterise the spectrum, and measure spectral and timing changes. Long-term X-ray variability was studied using archival ROSAT data. The XMM positions were used to identify the optical counterpart. We obtained UV to NIR photometry to characterise the companion, along with its 4000 d long I-band light curve. We observed LXP169 with Swift at two predicted eclipse times. We found a spin period of 168.8 s that did not change between two XMM observations. The X-ray spectrum, well characterised by a power law, was harder when the source was brighter. The X-ray flux of LXP169 is found to be variable by a factor of at least 10. The counterpart is highly variable on short and long timescales, and its photometry is that of an early-type star with a NIR excess. This classifies the source as a BeXRB pulsar. We observed a transit in the UV, thereby confirming that the companion star itself is eclipsed. We give an ephemeris for the transit of MJD 56203.877 + N*24.329. We propose and discuss the scenario where the matter captured from the companion's equatorial disc creates an extended region of high density around the neutron star (NS), which partially eclipses the companion as the NS transits in front of it. This is most likely the first time the compact object in an XRB is observed to eclipse its companion star. LXP169 would be the first eclipsing BeXRB, and a wealth of important information might be gained from additional observations, such as a measure of the possible Be disc/orbital plane misalignment, or the mass of the NS., Comment: Updated version of arXiv 1302.4665v1, accepted for publication in Astronomy and Astrophysics. 11 pages, 8 figures, 3 tables

The Be/X-ray binary SXP1062 is of especial interest owing to the large spin period of the neutron star, its large spin-down rate, and the association with a supernova remnant constraining its age. This makes the source an important probe for accretion physics. To investigate the long-term evolution of the spin period and associated spectral variations, we performed an XMM-Newton target-of-opportunity observation of SXP1062 during X-ray outburst. Spectral and timing analysis of the XMM-Newton data was compared with previous studies, as well as complementary Swift/XRT monitoring and optical spectroscopy with the SALT telescope were obtained. The spin period was measured to be P_s =(1071.01+-0.16) s on 2012 Oct 14. The X-ray spectrum is similar to that of previous observations. No convincing cyclotron absorption features, which could be indicative for a high magnetic field strength, are found. The high-resolution RGS spectra indicate the presence of emission lines, which may not completely be accounted for by the SNR emission. The comparison of multi-epoch optical spectra suggest an increasing size or density of the decretion disc around the Be star. SXP1062 showed a net spin-down with an average of (2.27+-0.44) s/yr over a baseline of 915 days., Comment: 8 pages, 6 figures, accepted for publication in A&A

[Abridged] The central field of the Andromeda galaxy (M 31) has been monitored, using the Chandra HRC-I detector (about 0.1-10 keV energy range) from 2006 to 2012 with the main aim to detect X-rays from optical novae. We present a systematic analysis of all X-ray sources found in the 41 nova monitoring observations, along with 23 M 31 central field HRC-I observations available from the Chandra data archive starting in December 1999. Based on these observations, we studied the X-ray long-term variability of the source population and especially of X-ray binaries in M 31. We created a catalogue of sources, detected in the 64 available observations, which add up to a total exposure of about 1 Ms. We present a point-source catalogue, containing 318 X-ray sources with detailed long-term variability information, 28 of which are published for the first time. The spatial and temporal resolution of the catalogue allows us to classify 115 X-ray binary candidates showing high X-ray variability or even outbursts in addition to 14 globular cluster X-ray binary candidates showing no significant variability. The analysis may suggest, that outburst sources are less frequent in globular clusters than in the field of M 31. We detected 7 supernova remnants, one of which is a new candidate and in addition resolved the first X-rays from a known radio supernova remnant. Besides 33 known optical nova/X-ray source correlations, we also discovered one previously unknown super-soft X-ray outburst and several new nova candidates. The catalogue contains a large sample of detailed long-term X-ray light curves in the M 31 central field, which helps to understand the X-ray population of our neighbouring spiral galaxy M 31., Comment: 51 pages, 17 figures, 9 tables, submitted to Astronomy and Astrophysics

Orofacial clefts are among the most common birth defects and result in an improper formation of the mouth or the roof of the mouth. Monosomy of the distal aspect of human chromosome 6p has been recognized as causative in congenital malformations affecting the brain and cranial skeleton including orofacial clefts. Among the genes located in this region is PAK1IP1, which encodes a nucleolar factor involved in ribosomal stress response. Here, we report the identification of a novel mouse line that carries a point mutation in the Pak1ip1 gene. Homozygous mutants show severe developmental defects of the brain and craniofacial skeleton, including a median orofacial cleft. We recovered this line of mice in a forward genetic screen and named the allele manta-ray (mray). Our findings prompted us to examine human cases of orofacial clefting for mutations in the PAK1IP1 gene or association with the locus. No deleterious variants in the PAK1IP1 gene coding region were recognized, however, we identified a borderline association effect for SNP rs494723 suggesting a possible role for the PAK1IP1 gene in human orofacial clefting.

Aims. We report on the recent observations of the supernova remnant SNR 1987A in the Large Magellanic Cloud with XMM-Newton. Carefully monitoring the evolution of the X-ray light curve allows to probe the complex circumstellar medium structure observed around the supernova progenitor star. Methods. We analyse all XMM-Newton observations of SNR 1987A from January 2007 to December 2011, using data from the EPIC-pn camera. Spectra from all epochs are extracted and analysed in a homogeneous way. Using a multi-shock model to fit the spectra across the 0.2-10 keV band we measure soft and hard X-ray fluxes with high accuracy. In the hard X-ray band we examine the presence and properties of Fe K ines. Our findings are interpreted in the framework of a hydrodynamics-based model. Results. The soft X-ray flux of SNR 1987A continuously increased in the recent years. Although the light curve shows a mild flattening, there is no sudden break as reported in an earlier work, a picture echoed by a revision of the Chandra light curve. We therefore conclude that material in the equatorial ring and out-of-plane HII regions are still being swept-up. We estimate the thickness of the equatorial ring to be at least 4.5x10^16 cm (0.0146 pc). This lower limit will increase as long as the soft X-ray flux has not reached a turn-over. We detect a broad Fe K line in all spectra from 2007 to 2011. The widths and centroid energies of the lines indicate the presence of a collection of iron ionisation stages. Thermal emission from the hydrodynamic model does not reproduce the low-energy part of the line (6.4-6.5 keV), suggesting that fluorescence from neutral and/or low ionisation Fe might be present., 4 pages, 3 figures, 2 tables. Accepted for publication in Astronomy and Astrophysics

We present a case of an amelanotic nodular melanoma occurring in a 26-year-old woman who carried a heterozygous (melancortin-1-receptor) MC1R 160R/W and tyrosinase (TYR) 402R/Q genotype and had a dark hair phenotype. We present dermoscopic, reflectance confocal microscopy (RCM) and histopathological images of the melanoma. We discuss the relationship between MC1R red hair colour (RHC) variants, TYR variants, phenotype and melanoma development. We also discuss the merits of RCM as an additional diagnostic aid for equivocal melanocytic lesions.

The Small Magellanic Cloud (SMC) hosts a large number of Be/X-ray binaries, however no Be/white dwarf system is known so far, although population synthesis calculations predict that they might be more frequent than Be/neutron star systems. XMMUJ010147.5-715550 was found as a new faint super-soft X-ray source (SSS) with a likely Be star optical counterpart. We investigate the nature of this system and search for further high-absorbed candidates in the SMC. We analysed the XMM-Newton X-ray spectrum and light curve, optical photometry, and the I-band OGLE III light curve. The X-ray spectrum is well represented by black-body and white dwarf atmosphere models with highly model-dependent temperature between 20 and 100 eV. The likely optical counterpart AzV 281 showed low near infrared emission during X-ray activity, followed by a brightening in the I-band afterwards. We find further candidates for high-absorbed SSSs with a blue star as counterpart. We discuss XMMUJ010147.5-715550 as the first candidate for a Be/white dwarf binary system in the SMC., 6 pages, 4 figures, accepted by A&A

(shortened) The SMC is ideally suited to investigating the recent star formation history from X-ray source population studies. It harbours a large number of Be/X-ray binaries, and the supernova remnants can be easily resolved with imaging X-ray instruments. We search for new supernova remnants in the SMC and in particular for composite remnants with a central X-ray source. We study the morphology of newly found candidate supernova remnants using radio, optical and X-ray images and investigate their X-ray spectra. Here we report on the discovery of the new supernova remnant around the recently discovered Be/X-ray binary pulsar SXP 1062 in radio and X-ray images. The Be/X-ray binary system is found near the centre of the supernova remnant, which is located at the outer edge of the eastern wing of the SMC. The remnant is oxygen-rich, indicating that it developed from a type Ib event. From XMM-Newton observations we find that the neutron star with a spin period of 1062 s shows a very high average spin-down rate of 0.26 s per day over the observing period of 18 days. From the currently accepted models, our estimated age of around 10000-25000 years for the supernova remnant is not long enough to spin down the neutron star from a few 10 ms to its current value. Assuming an upper limit of 25000 years for the age of the neutron star and the extreme case that the neutron star was spun down by the accretion torque that we have measured during the XMM-Newton observations since its birth, a lower limit of 0.5 s for the birth spin period is inferred. For more realistic, smaller long-term average accretion torques our results suggest that the neutron star was born with a correspondingly longer spin period. This implies that neutron stars in Be/X-ray binaries with long spin periods can be much younger than currently anticipated., Accepted for publication in A&A Letters; 5 pages; 4 figures

Many of the high mass X-ray binaries (HMXRBs) discovered in recent years in our Galaxy are characterized by a high absorption, most likely intrinsic to the system, which hampers their detection at the softest X-ray energies. We have undertaken a search for highly-absorbed X-ray sources in the Small Magellanic Cloud (SMC) with a systematic analysis of 62 XMM-Newton SMC observations. We obtained a sample of 30 sources showing evidence for an equivalent hydrogen column density larger than 3x10^23 cm^-2. Five of these sources are clearly identified as HMXRBs: four were already known (including three X-ray pulsars) and one, XMM J005605.8-720012, reported here for the first time. For the latter, we present optical spectroscopy confirming the association with a Be star in the SMC. The other sources in our sample have optical counterparts fainter than magnitude ~16 in the V band, and many of them have possible NIR counterparts consistent with highly reddened early type stars in the SMC. While their number is broadly consistent with the expected population of background highly-absorbed active galactic nuclei, a few of them could be HMXRBs in which an early type companion is severely reddened by local material., Comment: 10 pages, 4 figures, 4 tables. Accepted for publication by Astronomy & Astrophysics

One of the goals of the XMM-Newton survey of the Small Magellanic Cloud is the study of the Be/X-ray binary population. During one of our first survey observations a bright new transient - XMMUJ004814.0-732204 - was discovered. We present the analysis of the EPIC X-ray data together with optical observations, to investigate the spectral and temporal characteristics of XMMUJ004814.0-732204. We found coherent X-ray pulsations in the EPIC data with a period of (11.86642 +/- 0.00017) s. The X-ray spectrum can be modelled by an absorbed power-law with indication for a soft excess. Depending on the modelling of the soft X-ray spectrum, the photon index ranges between 0.53 and 0.66. We identify the optical counterpart as a B = 14.9mag star which was monitored during the MACHO and OGLE-III projects. The optical light curves show regular outbursts by ~0.5 mag in B and R and up to 0.9 mag in I which repeat with a time scale of about 1000 days. The OGLE-III optical colours of the star are consistent with an early B spectral type. An optical spectrum obtained at the 1.9 m telescope of the South African Astronomical Observatory in December 2009 shows H_alpha emission with an equivalent width of 3.5 +/- 0.6 A. The X-ray spectrum and the detection of pulsations suggest that XMMUJ004814.0-732204 is a new high mass X-ray binary pulsar in the SMC. The long term variability and the H_alpha emission line in the spectrum of the optical counterpart identify it as a Be/X-ray binary system., 7 pages, 8 figures, accepted by A&A

We report the results of our XMM-Newton monitoring of SN 1987A. The ongoing propagation of the supernova blast wave through the inner circumstellar ring caused a drastic increase in X-ray luminosity during the last years, enabling detailed high resolution X-ray spectroscopy with the Reflection Grating Spectrometer. The observations can be used to follow the detailed evolution of the arising supernova remnant. The fluxes and broadening of the numerous emission lines seen in the dispersed spectra provide information on the evolution of the X-ray emitting plasma and its dynamics. These were analyzed in combination with the EPIC-pn spectra, which allow a precise determination of the higher temperature plasma. We modeled individual emission lines and fitted plasma emission models. Especially from the observations between 2003 and 2007 we can see a significant evolution of the plasma parameters and a deceleration of the radial velocity of the lower temperature plasma regions. We found an indication (3-sigma-level) of an iron K feature in the co-added EPIC-pn spectra. The comparison with Chandra grating observations in 2004 yields a clear temporal coherence of the spectral evolution and the sudden deceleration of the expansion velocity seen in X-ray images ~6100 days after the explosion., Comment: 10 pages, 8 Figures; accepted by A&A

We observed RX J0520.5-6932 in the X-rays and studied the optical light curve of its counterpart to verify it as a Be/X-ray binary. We performed an XMM-Newton anticipated target of opportunity observation in January 2013 during an X-ray outburst of the source in order to search for pulsations and derive its spectral properties. We monitored the source with Swift to follow the evolution of the outburst and to look for further outbursts to verify the regular pattern seen in the optical light curve with a period of ~24.4 d. The XMM-Newton EPIC light curves show coherent X-ray pulsations with a period of 8.035331(15) s (1 sigma). The X-ray spectrum can be modelled by an absorbed power law with photon index of ~0.8, an additional black-body component with temperature of ~0.25 keV and an Fe K line. Phase-resolved X-ray spectroscopy reveals that the spectrum varies with pulse phase. We confirm the identification of the optical counterpart within the error circle of XMM-Newton at an angular distance of ~0.8 arcsec, which is an O9Ve star with known Halpha emission. By analyzing the combined data from three OGLE phases we derived an optical period of 24.43 d.The X-ray pulsations and long-term variability, as well as the properties of the optical counterpart, confirm that RX J0520.5-6932 is a Be/X-ray binary pulsar in the Large Magellanic Cloud. Based on the X-ray monitoring of the source we conclude that the event in January 2013 was a moderately bright type-I X-ray outburst, with a peak luminosity of 1.79e36 erg/s., Comment: 10 pages, 9 figures, accepted A&A

We observed the newly discovered X-ray source Swift J053041.9-665426 in the X-ray and optical regime to confirm its proposed nature as a high mass X-ray binary. We obtained XMM-Newton and Swift X-ray data, along with optical observations with the ESO Faint Object Spectrograph, to investigate the spectral and temporal characteristics of Swift J053041.9-665426. The XMM-Newton data show coherent X-ray pulsations with a period of 28.77521(10) s (1 sigma). The X-ray spectrum can be modelled by an absorbed power law with photon index within the range 0.76 to 0.87. The addition of a black body component increases the quality of the fit but also leads to strong dependences of the photon index, black-body temperature and absorption column density. We identified the only optical counterpart within the error circle of XMM-Newton at an angular distance of ~0.8 arcsec, which is 2MASS J05304215-6654303. We performed optical spectroscopy from which we classify the companion as a B0-1.5Ve star. The X-ray pulsations and long-term variability, as well as the properties of the optical counterpart, confirm that Swift J053041.9-665426 is a new Be/X-ray binary pulsar in the Large Magellanic Cloud., 10 pages, 8 figures, accepted for publication in A&A

The XMM-Newton survey of the Small Magellanic Cloud (SMC) revealed 3053 X-ray sources with the majority expected to be active galactic nuclei (AGN) behind the SMC. However, the high stellar density in this field often does not allow assigning unique optical counterparts and hinders source classification. On the other hand, the association of X-ray point sources with radio emission can be used to select background AGN with high confidence, and to constrain other object classes like pulsar wind nebula. To classify X-ray and radio sources, we use clear correlations of X-ray sources found in the XMM-Newton survey with radio-continuum sources detected with ATCA and MOST. Deep radio-continuum images were searched for correlations with X-ray sources of the XMM-Newton SMC-survey point-source catalogue as well as galaxy clusters seen with extended X-ray emission. Eighty eight discrete radio sources were found in common with the X-ray point-source catalogue in addition to six correlations with extended X-ray sources. One source is identified as a Galactic star and eight as galaxies. Eight radio sources likely originate in AGN that are associated with clusters of galaxies seen in X-rays. One source is a PWN candidate. We obtain 43 new candidates for background sources located behind the SMC. A total of 24 X-ray sources show jet-like radio structures.

To confirm faint Be/X-ray binary candidates from the XMM-Newton survey of the Small Magellanic Cloud, we searched for X-ray outbursts in archival ROSAT observations. We found that RXJ0123.4-7321 was much brighter when detected with ROSAT than seen 16 years later by XMM-Newton. We analysed the ROSAT observations and the OGLE I-band light curve of the optical counterpart to investigate the nature of the system. High long-term variability in the X-ray flux of a factor of ~150 was found between the ROSAT and XMM-Newton detections, indicating strong outburst activity during the ROSAT observations. The I-band light curve reveals long-term variability and regular outbursts with a period of (119.9+-2.5) days indicating the orbital period of the binary system. The large X-ray flux variations and the properties of the optical counterpart confirm RXJ0123.4-7321 as a new Be/X-ray binary in the wing of the Small Magellanic Cloud.

We present new X-ray and radio data of the LMC SNR candidate DEM L205, obtained by XMM-Newton and ATCA, along with archival optical and infrared observations. We use data at various wavelengths to study this object and its complex neighbourhood, in particular in the context of the star formation activity, past and present, around the source. We analyse the X-ray spectrum to derive some remnant's properties, such as age and explosion energy. Supernova remnant features are detected at all observed wavelengths: soft and extended X-ray emission is observed, arising from a thermal plasma with a temperature kT between 0.2 keV and 0.3 keV. Optical line emission is characterised by an enhanced [SII]/Halpha ratio and a shell-like morphology, correlating with the X-ray emission. The source is not or only tentatively detected at near-infrared wavelengths (< 10 microns), but there is a detection of arc-like emission at mid and far-infrared wavelengths (24 and 70 micron) that can be unambiguously associated with the remnant. We suggest that thermal emission from dust heated by stellar radiation and shock waves is the main contributor to the infrared emission. Finally, an extended and faint non-thermal radio emission correlates with the remnant at other wavelengths and we find a radio spectral index between -0.7 and -0.9, within the range for SNRs. The size of the remnant is ~79x64 pc and we estimate a dynamical age of about 35000 years. We definitely confirm DEM L205 as a new SNR. This object ranks amongst the largest remnants known in the LMC. The numerous massive stars and the recent outburst in star formation around the source strongly suggest that a core-collapse supernova is the progenitor of this remnant. (abridged), 11 pages, 6 figures, accepted for publication in A&A

The number of known Be/X-ray binaries in the Large Magellanic Cloud is small compared to the observed population of the Galaxy or the Small Magellanic Cloud. The discovery of a system in outburst provides the rare opportunity to measure its X-ray properties in detail. IGR J05414-6858 was discovered in 2010 by INTEGRAL and found in another outburst with the Swift satellite in 2011. In order to characterise the system, we analysed the data from a follow-up XMM-Newton target of opportunity observation of the 2011 outburst and investigate the stellar counterpart with photometry and spectroscopy. We modelled the X-ray spectra from the EPIC instruments on XMM-Newton and compared them with Swift archival data. In the X-ray and optical light curves, we searched for periodicities and variability. The optical counterpart was classified using spectroscopy obtained with ESO's Faint Object Spectrograph at NTT. The X-ray spectra as seen in 2011 are relatively hard with a photon index of ~0.3-0.4 and show only low absorption. They deviate significantly from earlier spectra of a probable type II outburst in 2010. The neutron star spin period of P_s = 4.4208 s was discovered with EPIC-pn. The I-band light curve revealed a transition from a low to a high state around MJD 54500. The optical counterpart is classified to B0-1IIIe and shows Halpha emission and a variable NIR excess, vanishing during the 2010 outburst. In the optical high state, we found a periodicity at 19.9 days, probably caused by binarity and indicating the orbital period., Accepted for publication in A&A, 10 pages, 12 figures

Author Manuscript 20 Apr 2012., Observations of SN 1987A by the Chandra High Energy Transmission Grating (HETG) in 1999 and the XMM-Newton Reflection Grating Spectrometer (RGS) in 2003 show very broad (v-b) lines with a full width at half-maximum (FWHM) of order 10[superscript 4] km s[superscript –1]; at these times the blast wave (BW) was primarily interacting with the H II region around the progenitor. Since then, the X-ray emission has been increasingly dominated by narrower components as the BW encounters dense equatorial ring (ER) material. Even so, continuing v-b emission is seen in the grating spectra suggesting that the interaction with H II region material is ongoing. Based on the deep HETG 2007 and 2011 data sets, and confirmed by RGS and other HETG observations, the v-b component has a width of 9300 ± 2000 km s[superscript –1] FWHM and contributes of order 20% of the current 0.5-2 keV flux. Guided by this result, SN 1987A's X-ray spectra are modeled as the weighted sum of the non-equilibrium-ionization emission from two simple one-dimensional hydrodynamic simulations; this "2 × 1D" model reproduces the observed radii, light curves, and spectra with a minimum of free parameters. The interaction with the H II region (ρinit ≈ 130 amu cm[superscript –3], ± 15° opening angle) produces the very broad emission lines and most of the 3-10 keV flux. Our ER hydrodynamics, admittedly a crude approximation to the multi-D reality, gives ER densities of ~10[superscript 4] amu cm[superscript –3], requires dense clumps (×5.5 density enhancement in ~30% of the volume), and predicts that the 0.5-2 keV flux will drop at a rate of ~17% per year once no new dense ER material is being shocked.

Aims. IKT 16 is an X-ray and radio-faint supernova remnant (SNR) in the Small Magellanic Cloud (SMC). A previous X-ray study of this SNR found a hard X-ray source near its centre. Using all available archival and proprietary XMM-Newton data, alongside new multi-frequency radio-continuum surveys and optical observations at Hα and forbidden [SII ]a nd [OIII] lines, we aim to constrain the properties of the SNR and discover the nature of the hard source within. Methods. We combine XMM-Newton datasets to produce the highest quality X-ray image of IKT 16 to date. We use this, in combination with radio and optical images, to conduct a multi-wavelength morphological analysis of the remnant. We extract separate spectra from the SNR and the bright source near its centre, and conduct spectral fitting of both regions. Results. We find IKT 16 to have a radius of 37 ± 3 pc, with the bright source located 8 ± 2 pc from the centre. This is the largest known SNR in the SMC. The large size of the remnant suggests it is likely in the Sedov-adiabatic phase of evolution. Using a Sedov model to fit the SNR spectrum, we find an electron temperature kT of 1.03 ± 0.12 keV and an age of ≈14700 yr. The absorption found requires the remnant to be located deep within the SMC. The bright source is fit with a power law with index Γ= 1.58 ± 0.07, and is associated with diffuse radio emission extending towards the centre of the SNR. We argue that this source is likely to be the neutron star remnant of the supernova explosion, and infer its transverse kick velocity to be 580 ± 100 km s −1 . The X-ray and radio properties of this source strongly favour a pulsar wind nebula (PWN) origin.

The XMM-Newton survey of the Small Magellanic Cloud (SMC) was performed to study the population of X-ray sources in this neighbouring galaxy. During one of the observations, the symbiotic binary SMC3 was found at its highest X-ray luminosity observed until now. In SMC3 wind accretion from a giant donor star onto a white dwarf is believed to cause steady hydrogen burning on the white dwarf surface, making such systems candidates for supernova type Ia progenitors. It was suggested that the X-ray source is eclipsed every ~4.5 years by the companion star and its stellar wind to explain the large X-ray variability seen in ROSAT data. We use the available X-ray data to test this scenario. We present the ~20 year X-ray light curve of SMC3 and study the spectral evolution as seen with XMM-Newton/EPIC-pn to investigate possible scenarios which can reproduce the high X-ray variability. We did not find significant variations in the photo-electric absorption, as it would be expected during eclipse ingress and egress. Instead, the X-ray spectra from different intensity levels, when modelled by black-body emission, can be better explained by variations either in normalisation (by a factor of ~50) or in temperature (kT between 24 eV and 34 eV). The light curve shows maxima and minima with slow transitions between them. To explain the gradual variations in the X-ray light curve and to avoid changes in absorption by neutral gas, a predominant part of the stellar wind must be ionised by the X-ray source. Compton scattering with variable electron column density (of the order of 5 x 10^24 cm^-2) along the line of sight could then be responsible for the intensity changes. The X-ray variability of SMC3 could also be caused by temperature changes in the hydrogen burning envelope of the white dwarf, an effect which could even dominate if the stellar wind density is not sufficiently high., 6 pages, 3 figures, submitted to A&A

During an X-ray survey of the Small Magellanic Cloud, carried out with the XMM-Newton satellite, we detected significant soft X-ray emission from the central star of the high-excitation planetary nebula SMP SMC 22. Its very soft spectrum is well fit with a non local thermodynamical equilibrium model atmosphere composed of H, He, C, N, and O, with abundances equal to those inferred from studies of its nebular lines. The derived effective temperature of 1.5x10^5 K is in good agreement with that found from the optical/UV data. The unabsorbed flux in the 0.1-0.5 keV range is about 3x10^{-11} erg cm^-2 s^-1, corresponding to a luminosity of 1.2x10^37 erg/s at the distance of 60 kpc. We also searched for X-ray emission from a large number of SMC planetary nebulae, confirming the previous detection of SMP SMC 25 with a luminosity of (0.2-6)x10^35 erg/s (0.1-1 keV). For the remaining objects that were not detected, we derived flux upper limits corresponding to luminosity values from several tens to hundreds times smaller than that of SMP SMC 22. The exceptionally high X-ray luminosity of SMP SMC 22 is probably due to the high mass of its central star, quickly evolving toward the white dwarf's cooling branch, and to a small intrinsic absorption in the nebula itself., Accepted for publication on Astronomy and Astrophysics