Search

Your search keyword '"Richard Kolesar"' showing total 3 results
Start Over Author "Richard Kolesar"
3 results on '"Richard Kolesar"'

1. Tracking auditory mismatch negativity responses during full conscious state and coma

Author

Adianes Herrera-Diaz, Rober Boshra, Paniz Tavakoli, Chia-Yu A. Lin, Netri Pajankar, Elham Bagheri, Richard Kolesar, Alison Fox-Robichaud, Cindy Hamielec, James P. Reilly, and John F. Connolly

Subjects
mismatch negativity, event-related potentials (ERP), coma, disorder of consciousness, brain injury, Neurology. Diseases of the nervous system, RC346-429
Abstract

The mismatch negativity (MMN) is considered the electrophysiological change-detection response of the brain, and therefore a valuable clinical tool for monitoring functional changes associated with return to consciousness after severe brain injury. Using an auditory multi-deviant oddball paradigm, we tracked auditory MMN responses in seventeen healthy controls over a 12-h period, and in three comatose patients assessed over 24 h at two time points. We investigated whether the MMN responses show fluctuations in detectability over time in full conscious awareness, or whether such fluctuations are rather a feature of coma. Three methods of analysis were utilized to determine whether the MMN and subsequent event-related potential (ERP) components could be identified: traditional visual analysis, permutation t-test, and Bayesian analysis. The results showed that the MMN responses elicited to the duration deviant-stimuli are elicited and reliably detected over the course of several hours in healthy controls, at both group and single-subject levels. Preliminary findings in three comatose patients provide further evidence that the MMN is often present in coma, varying within a single patient from easily detectable to undetectable at different times. This highlights the fact that regular and repeated assessments are extremely important when using MMN as a neurophysiological predictor of coma emergence.

Published
2023
Full Text
View/download PDF

2. Rationale and design of the HIP fracture Accelerated surgical TreaTment And Care tracK (HIP ATTACK) Trial : a protocol for an international randomised controlled trial evaluating early surgery for hip fracture patients

Author

Benjamin Deheshi, Gavin C A Wood, Aamer Nabi Nur, Maria Tiboni, Leslie Gauthier, Ekaterine Popova, Masood Umer, Patrice Forget, Parag Sancheti, Flávia Kessler Borges, Alben Sigamani, Philip J. Devereaux, Iain K. Moppett, Mitchell Winemaker, Wojciech Szczeklik, Mohit Bhandari, Abdel-Rahman Lawendy, Richard Kolesar, Vikas Tandon, Mariano Balaguer-Castro, Paweł Ślęczka, Shirley Pettit, Jordi Teixidor-Serra, Victoria Avram, Michael McGillion, Giovanni Landoni, Valerie Harvey, Ernesto Guerra-Farfán, Chew Yin Wang, Bobby John, Jordi Tomas-Hernandez, Ameen Patel, Anthony Adili, John Neary, Robert J. Feibel, Justin de Beer, Mmampapatla Thomas Ramokgopa, Richard Jenkinson, Bruce M Biccard, Jessica Vincent, Kim Alvarado, Harsha Shanthanna, Institut Català de la Salut, [Borges FK] Department of Perioperative Medicine, Population Health Research Institute, Hamilton, Ontario, Canada. [Bhandari M, Avram V] Department of Surgery, McMaster University, Hamilton, Ontario, Canada. [Patel A] Department of Medicine, McMaster University, Hamilton, Ontario, Canada. [Guerra-Farfán E, Teixidor-Serra J, Tomas-Hernandez J] Servei de Cirurgia Ortopèdica i Traumatologia, Hospital Universitari Vall d'Hebron, Barcelona, Spain. [Sigamani A] Department of Clinical Research, Narayana Health, Bangalore, India., Vall d'Hebron Barcelona Hospital Campus, Supporting clinical sciences, Anesthesiology, Borges, Flavia K, Bhandari, Mohit, Patel, Ameen, Avram, Victoria, Guerra-Farfán, Ernesto, Sigamani, Alben, Umer, Masood, Tiboni, Maria, Adili, Anthony, Neary, John, Tandon, Vika, Sancheti, Parag K, Lawendy, Abdelrahman, Jenkinson, Richard, Ramokgopa, Mmampapatla, Biccard, Bruce M, Szczeklik, Wojciech, Wang, Chew Yin, Landoni, Giovanni, Forget, Patrice, Popova, Ekaterine, Wood, Gavin, Nabi Nur, Aamer, John, Bobby, Ślęczka, Paweł, Feibel, Robert J, Balaguer-Castro, Mariano, Deheshi, Benjamin, Winemaker, Mitchell, de Beer, Justin, Kolesar, Richard, Teixidor-Serra, Jordi, Tomas-Hernandez, Jordi, Mcgillion, Michael, Shanthanna, Harsha, Moppett, Iain, Vincent, Jessica, Pettit, Shirley, Harvey, Valerie, Gauthier, Leslie, Alvarado, Kim, and Devereaux, P J

Subjects
Male, Time Factors, accelerated surgery, law.invention, 0302 clinical medicine, Postoperative Complications, Randomized controlled trial, law, Informed consent, Protocol, 030212 general & internal medicine, Stroke, Medicine(all), Hip fracture, Mortality rate, Wounds and Injuries::Fractures, Bone::Femoral Fractures::Hip Fractures [DISEASES], General Medicine, Middle Aged, Other subheadings::Other subheadings::/surgery [Other subheadings], 3. Good health, Pulmonary embolism, Research Design, hip fracture, randomised control trial, Female, medicine.medical_specialty, heridas y lesiones::fracturas óseas::fracturas del fémur::fracturas de cadera [ENFERMEDADES], 03 medical and health sciences, Health Care Facilities, Manpower, and Services::Health Services::Preventive Health Services::Early Medical Intervention [HEALTH CARE], medicine, Health Care Quality, Access, and Evaluation::Quality of Health Care::Health Care Evaluation Mechanisms::Epidemiologic Study Characteristics::Clinical Protocols::Clinical Trial Protocols as Topic [HEALTH CARE], Humans, Articulació coxofemoral - Cirurgia, Aged, business.industry, Hip Fractures, Otros calificadores::Otros calificadores::/cirugía [Otros calificadores], Perioperative, medicine.disease, calidad, acceso y evaluación de la atención sanitaria::calidad de la atención sanitaria::mecanismos de evaluación de la atención sanitaria::características de los estudios epidemiológicos::protocolos clínicos::protocolos de ensayos clínicos como asunto [ATENCIÓN DE SALUD], Physical therapy, instalaciones, servicios y personal de asistencia sanitaria::servicios de salud::servicios preventivos de salud::intervención médica temprana [ATENCIÓN DE SALUD], Observational study, Surgery, business, 030217 neurology & neurosurgery, Assaigs clínics
Abstract

IntroductionAnnually, millions of adults suffer hip fractures. The mortality rate post a hip fracture is 7%–10% at 30 days and 10%–20% at 90 days. Observational data suggest that early surgery can improve these outcomes in hip fracture patients. We designed a clinical trial—HIP fracture Accelerated surgical TreaTment And Care tracK (HIP ATTACK) to determine the effect of accelerated surgery compared with standard care on the 90-day risk of all-cause mortality and major perioperative complications.Methods and analysisHIP ATTACK is a multicentre, international, parallel group randomised controlled trial (RCT) that will include patients ≥45 years of age and diagnosed with a hip fracture from a low-energy mechanism requiring surgery. Patients are randomised to accelerated medical assessment and surgical repair (goal within 6 h) or standard care. The co-primary outcomes are (1) all-cause mortality and (2) a composite of major perioperative complications (ie, mortality and non-fatal myocardial infarction, pulmonary embolism, pneumonia, sepsis, stroke, and life-threatening and major bleeding) at 90 days after randomisation. All patients will be followed up for a period of 1 year. We will enrol 3000 patients.Ethics and disseminationAll centres had ethics approval before randomising patients. Written informed consent is required for all patients before randomisation. HIP ATTACK is the first large international trial designed to examine whether accelerated surgery can improve outcomes in patients with a hip fracture. The dissemination plan includes publishing the results in a policy-influencing journal, conference presentations, engagement of influential medical organisations, and providing public awareness through multimedia resources.Trial registration numberNCT02027896; Pre-results.

Published
2019

3. Abstracts

Author

Brian P. Kavanagh, Cuong Ngo, Karen Raymer, Homer Yang, Jamal A. Alhashemi, Anne C. P. Lui, Dennis Reid, Nicholas Cicutti, Barbra Krepski, Gordon Wood, Daren K. Heyland, Neal H. Badner, John M. Murkin, Jim Mohr, F. Neil McKenzie, Peter J. A. van der Starre, W. T. van Rooyen-Butijn, Kristine Wilson-Yang, Kevin Teoh, R. M. K. W. Lee, Imtiaz Hossain, Davy Cheng, Jacek Karski, Buvanendran Asokumar, Alan Sandier, Marc A. St-Amand, Alan H. Menkis, Donal B. Downey, William Nantau, Sandy Adams, Noreen Dowd, David Wong, Jo Carroll-Munro, Clare Trachuk, N. Cregg, D. C. H. Cheng, W. G. Williams, J. M. Karski, S. Siu, G. Webb, Davy C. H. Cheng, David T. Wong, Rafal Kustra, Robert J. Tibshirani, Dany L. Côté, David E. Lacey, Kenneth M. LeDez, Julia A. Smith, Edward T. Crosby, Fredrick K. Orkin, A. Fisher, G. Volgyesi, J. Silverman, S. Edelstein, J. Rucker, L. Sommer, S. Dunington, L. Roy, C. Crochetière, M. -Y. Arsenault, E. Villeneuve, L. Lortie, Caroline S. Grange, M. Joanne Douglas, Timothy J. Adams, Pamela M. Merrick, S. Brian Lucas, Pamela J. Morgan, Stephen Halpern, Jason Lo, Carolyn L. Giesinger, Stephen H. Halpern, Terrance W. Breen, Srigowri Vishnubala, Geeta R. Shetty, M. De Kock, A. Lagmiche, J. L. Scholtes, Wlodzimierz Grodecki, Peter J. Duffy, Kathryn A. Hull, Geoffrey S. Hawboldt, Alexander J. Clark, J. Bruce Smith, Richard W. Norman, W. Scott Beattie, A. Sandier, M. Jewett, L. Valiquette, J. Katz, Y. Fradet, D. Redelmeier, H. Sampson, Jeff Cole, Todd Chedore, Walter Snedden, Robert G. Green, Mitchel B. Sosis, Philip I. Robles, Edward R. Lazar, Donald T. Jolly, Yun K. Tarn, Soheir R. Tawfik, Alexander S. Clanachan, Avaleigh Milne, Travis Beamish, D. J. Cuillerier, M. D. Sharpe, J. K. Lee, M. Basta, A. D. Krahn, G. J. Klein, R. Yee, Narendra Vakharia, Heather Francis, Louis Scheepers, Himat Vaghadia, Joanne Carrier, René Martin, Marline Pirlet, Yves Claprood, Jean-Pierre Tétrault, T. D. Wong, L. Ryner, P. Kozlowski, G. Scarth, R. K. Warrian, G. Lefevre, D. Thiessen, L. Girling, L. Doiron, C. McCudden, J. Saunders, W. A. C. Mutch, Stéphan Langevin, Martin R. Lessard, Claude A. Trépanier, Gregory M. T. Hare, Johnson C. S. Ngan, Dan Viskari, A. Berrill, Christian Jodoin, Jacques Couture, François Bellemare, Stephen Farmer, Holly Muir, Phyllis Money, Brian Milne, Joel Parlow, Jennifer Raymond, Julie M. Williams, Rosemary A. Craen, Teresa Novick, Wendy Komar, Luc Frenette, Jerry Cox, B. Lockhart, P. McArdle, D. Eckhoff, S. Bynon, Wojciech B. Dobkowski, David R. Grant, William J. Wall, Edgar G. Chedrawy, Richard I. Hall, Vivian Nedelcu, Jean-Paul Viale, Gérard Bégou, Pierre Sagnard, Richard Hughson, Luc Quintin, Éric Troncy, Jean-Paul Collet, Stan Shapiro, Jean-Gilles Guimond, Louis Blair, Thiérry Ducruet, Martin Francœur, Marc Charbonneau, Gilbert Blaise, W. Snedden, E. Bernadska, H. I. Manson, Juditli L. Kutt, Beruie Y. Mezon, Osamu Nishida, Ramiro Arellano, Patty Boylen, Wilfred DeMajo, David P. Archer, Sheldon H. Roth, Sitaram Raman, Pirjo Manninen, Kevin Boyle, Aleksa Cenic, Ting-Yim Lee, Adrian W. Gelb, F. X. Reinders, J. I. M. Brown, A. J. Baker, R. J. Moulton, L. Schlichtert, Stephan K. W. Schwarz, Ernest Puil, Barry A. Finegan, Brendan T. Finucane, Matt M. Kurrek, J. Hugh Devitt, Doreen Cleave-Hogg, John Bradley, Robert Byrick, Salvatore M. Spadafora, John G. Fuller, Mark H. Gelula, Kelly Mayson, Bruce Forster, R. J. Byrick, D. J. McKnight, M. Kurrek, M. Kolton, D. Cleave-Hogg, J. Haughton, S. Halpern, J. Kronberg, Sandy Shysh, Chris Eagle, A. Joel Dagnone, Joel L. Parlow, G. Blaise, F. Yang, H. Nguyen, E. Troncy, G. Czaika, Ireneusz Wachowski, Hervé Deladrière, Chantal Cambier, Philippe Pendeville, O. R. Hung, E. Coonan, S. C. Whynot, M. Mezei, Anthony M. -H. Ho, Ingrid S. Luchsinger, Elizabeth Ling, Doreen Mashava, Herbert M. Chinyanga, Marsha M. Cohen, Melissa Shaw, J. A. Robblee, R. S. Labow, F. D. Rubens, A. M. Diemunsch, R. Gervais, D. K. Rose, M. M. Cohen, L. O’Brien-Pallas, C. Copplestone, K. Karkouti, K. Sykora, Shirley L. W. Cheung, Peter D. Booker, Roger Franks, Marco Pozzi, Beverley Guard, Nancy Sikich, Jerrold Lerman, Mark Levine, Hilton Swan, Peter Cox, Carolyne Montgomery, Gillian Dunn, Russell Bourne, Anna Kinahan, James McCormack, Gillian S. Dunn, Eleanor J. Reimer, Peter Sanderson, Peter M. Sanderson, Carolyne J. Montgomery, Terri A. Betts, Guy R. Orlay, David H. Wong, Marsha Cohen, A. A. Al-Kaisy, V. Chan, P. Peng, A. Perlas, A. Miniad, Edward V. Cushing, Keith R. Mills, Hossam El-Beheiry, Shokrollah S. Jahromi, John Weaver, Mary Morris, Peter L. Carien, Robert McTaggart Cowan, Jonathan Richards, Blair T. Henderson, Robert J. Hudson, Ian R. Thomson, Michael Moon, Mark D. Peterson, Morley Rosenbloom, Patrick J. Davison, Mohamed Ali, Naheed S. Ali, Norman R. Searle, Ian Thomson, Micheline Roy, Line Gagnon, A. Lye, F. Walsh, W. Middleton, D. Wong, A. Langer, L. Errett, C. D. Mazer, Karin M. Williamson, Graham Smith, Kandiah P. Gnanendran, S. J. Bignell, S. Jones, J. Sleigh, M. Arnell, Jan-Ake I. Schultz, David W. Fear, S. Ganapathy, C. Moote, R. Wassermann, J. Watson, K. Armstrong, Aznif Ozsolak Calikyan, Oya Yilmaz, Yildiz Kose, Philip Peng, Vincent Chan, Frances Chung, Andrew R. Claxton, Ananthan Krishnathas, Gabor Mezei, Terri L. Paul, Jacqueline A. Doyle, Mahesh Mehta, Luiz G. R. DeLima, Lucia E. O. Silva, Warren L. May, Roy J. Maliakkal, Richard Kolesar, Sara Rafuse, Mary Fletcher, Geoffrey Dunn, Michael Curran, Paul Bragg, Wayne Chamberlain, MaryLou Crossan, H. Sandhu, S. Spadafora, R. Mian, B. Evans, L. Hurst, and S. Katsiris

Subjects
Anesthesiology and Pain Medicine, General Medicine
Published
1997
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results