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PDF file, 871K, S1 Chromogenic staining (DAB, brown) of paraffin-embedded DLBCL cell lines DHL4, and Toledo, untreated and BCR crosslinked, with anti-pLYN (Y396), anti-pSYK (Y323), and anti-pBTK (Y551); S2 Schematic illustration of Tissuequest analysis workflow. Individual cells are first identified by finding the nuclei (DAPI); S3 Qualitative Western blot of whole cell lysates for untreated (BCR-) and crosslinked (BCR+) cell lines; S4 S4 Chromogenic staining (DAB, brown) of two paraffin-embedded patient DLBCL specimens with anti-pLYN (Y396), anti-pSYK (Y323), and anti-pBTK (Y551); S5 (A) Schematic illustration of Tissuequest workflow extended to subcellular localization of FOXO1. In this example there are 83% of all cells that are positive for FOXO1 and 67% of the cells show cytoplasmic FOXO1 staining (67%). The ratio of these percentages is used to calculate the Fcyt score; S6 (A) Chromogenic staining (DAB, brown) of paraffin-embedded DLBCL cell lines DHL4, and Toledo, untreated and BCR crosslinked, with anti- FOXO1; S7 (A) IHC staining of paraffin-embedded DLBCL cell lines U2932, DHL6 and Toledo, untreated and crosslinked, with anti-pAKTsub (red) and DAPI (blue); S8 (A) Comparison of immunofluorescent images evaluated by an expert using a 3-tier system (0 - negative, 1 - weak positive, 2 - strong positive); S9 Comparison of FOXO1 cytoplasmic localization and BCR signaling in primary DLBCL tumors.

PDF file - 462K, Table S1: pLYN, pSYK and pBTK levels in DLBCL cell lines; S2 DLBCL cell line classification

Purpose: B-cell receptor (BCR)–mediated signaling is important in the pathogenesis of a subset of diffuse large B-cell lymphomas (DLBCL) and the BCR-associated kinases SYK and BTK have recently emerged as potential therapeutic targets. We sought to identify a signature of activated BCR signaling in DLBCL to aid the identification of tumors that may be most likely to respond to BCR-pathway inhibition.Experimental Design: We applied quantitative immunofluorescence (qIF) using antibodies to phosphorylated forms of proximal BCR signaling kinases LYN, SYK, and BTK and antibody to BCR-associated transcription factor FOXO1 on BCR-cross-linked formalin-fixed paraffin-embedded (FFPE) DLBCL cell lines as a model system and on two clinical cohorts of FFPE DLBCL specimens (n = 154).Results: A robust signature of active BCR signaling was identified and validated in BCR-cross-linked DLBCL cell lines and in 71/154 (46%) of the primary DLBCL patient specimens. Further analysis of the primary biopsy samples revealed increased nuclear exclusion of FOXO1 among DLBCL with qIF evidence of active BCR signaling compared with those without (P = 0.004). Nuclear exclusion of FOXO1 was also detected in a subset of DLBCL without evidence of proximal BCR signaling suggesting that alternative mechanisms for PI3K/AKT activation may mediate FOXO1 subcellular localization in these cases.Conclusion: This study establishes the feasibility of detecting BCR activation in primary FFPE biopsy specimens of DLBCL. It lays a foundation for future dissection of signal transduction networks in DLBCL and provides a potential platform for evaluating individual tumors in patients receiving novel therapies targeting the BCR pathway. Clin Cancer Res; 18(22); 6122–35. ©2012 AACR.

Maxillary frenectomy in children is a common procedure, but concerns about scar tissue affecting diastema closure prevent many clinicians from treating prior to orthodontics.To determine if maxillary frenectomy is safe and if diastema size is affected by early treatment.Paediatric patients with hypertrophic maxillary frena were treated under local anaesthesia with diode laser and COIn total, 109 patients were included: 95 patients with primary dentition (39% male; mean age 1.9 years±1.5 years) and 14 with mixed dentition (43% male; mean age 8.1±1.3 years) with a mean follow-up of 18.0±13.2 months. No adverse outcomes were noted other than minor pain and swelling. In the primary dentition, a decrease in diastema width was observed in 94.7% with a mean closure of -1.4±1.0mm (range +0.7 to -5.1mm). In the mixed dentition, a decrease in diastema width was observed in 92.9% with a mean closure of -1.8±0.8mm (range 0 to -3.5mm). 74.5% of patients in the primary dentition and 75% of patients in the mixed dentition with preoperative diastema2mm improved to2mm width postoperatively.Frenectomy is associated with cosmetic and oral hygiene benefits and when performed properly, does not impede diastema closure and may aid closure. Technique and case selection are critical to successful outcomes. IRB ethics approval was obtained from Solutions IRB protocol #2018/12/8, and this investigation was self-funded.

This paper discusses the purpose, reach, and function of the Non-Profit and Civic Engagement (NPACE) Center in the Department of Communication . Additionally, it explores how the ground-up creation of NPACE resulted from a thorough examination of the strengths and needs of both department and community and how the center offers substantive solutions to meet real-life challenges of both. Along the way, the paper addresses how faculty members negotiated with faculty and administrators across campus to gain support to launch the center. Moreover, the paper discusses key achievements of a few select projects executed in the past 5 years of service to the university and community. It also addresses the value of NPACE to its students, including a recent trend that has potential for further examination regarding the effect of the learning model and the center on fostering the civic and community engagement of graduates. Finally, the paper discusses emerging challenges, lessons learned, and opportunities for NPACE. Subscribe to JNEL

Background Mastopexy and reduction mammaplasty are often limited by the patient's poor native soft tissue quality, resulting in ptosis recurrence and loss of rejuvenated surgical results. Surgical scaffolds and acellular dermal matrices are used in these procedures to provide physical and mechanical stabilization of weakened or compromised tissue. GalaFLEX scaffold, made from poly-4-hydroxybutyrate (P4HB), is a next-generation product for soft tissue reinforcement that resorbs gradually while aiding tissue regeneration to achieve excellent outcomes. Objectives To assess the clinical performance of GalaFLEX scaffold in soft tissue reinforcement during elective mastopexy and reduction mammaplasty. Methods This multicenter, single-arm, observational study assessed product performance and outcomes of GalaFLEX scaffold when used in breast surgery. Outcomes included ptosis correction and maintenance, associated adverse events, patient and surgeon satisfaction, and mammographic and ultrasound imaging evaluation. Results At 6 centers in the US, 62 of 69 enrolled patients were treated. Of this population, 89.7% had successful ptosis correction and maintenance at 1 year, with high patient and surgeon satisfaction for breast shape, droop/sag of the breast, and maintenance of results at 1 year. There were 5 adverse events deemed related to the device (8.0%), including nerve pain, breast swelling, ptosis, and 2 instances of asymmetry. Conclusions GalaFLEX scaffold safely and successfully supports and elevates breast tissue in mastopexy and reduction mammaplasty, with maintained support at 1 year. Surgeon and patient satisfaction were high. No mammogram or ultrasound interference was detected. Level of Evidence 4

Background: High-intensity focused ultrasonography (HIFU) is a nonsurgical, noninvasive method for body sculpting in nonobese patients. The technique ablates subcutaneous adipose tissue by causing molecular vibrations that increase tissue temperature and induce rapid cell necrosis. Objectives: The authors evaluate the long-term safety of a HIFU device for sculpting the abdomen and flanks. Methods: Adults with subcutaneous abdominal fat ≥2.5 cm in thickness who met screening criteria were randomized to receive HIFU treatment of the anterior abdomen and flanks at 1 of 3 energy levels (3 passes per patient): 47 J/cm2 (141 J/cm2 total), 59 J/cm2 (177 J/cm2 total), or 0 J/cm2 (no energy applied; sham control). Safety was assessed for 24 weeks and included laboratory testing, physical examinations, and documentation of adverse events. Results: Adverse events (AE) included mild to moderate discomfort, ecchymosis, and edema, all of which were transient. There were no reports of scarring or burns and no clinically meaningful changes in lipid panel findings, inflammatory markers, or renal or hepatic function. Physical examination results were unremarkable. Conclusions: This HIFU device exhibited an AE profile similar to that of sham treatment. There were no significant changes from baseline in laboratory values, including lipid levels. Level of Evidence: 2 ![Graphic][1] [1]: /embed/inline-graphic-1.gif

This article explores whether some new acellular dermal matrices (ADMs) can be applied to breast augmentation or reconstruction revision, and particularly whether they can withstand the centripetal pull and prevent recurrent stretch deformities following periareolar mastopexy. Acellular dermis use in breast reconstruction and aesthetic breast revision is a fortuitous development, because their original purpose was for burn reconstruction. Although level 1 evidence remains lacking, ADMs have become integral adjuncts in breast reconstruction, complex hernia, and aesthetic breast revision. New applications continue to be explored, although these are in early stages of development and their long-term value remains to be confirmed.

A simple approach based on (i) the glue model for gold, (ii) an empirical force field for C60 and (iii) the charge equilibration plus the Born-Mayer potential for their interaction shows that the two experimentally detected structures for C60 on Au(110) 6] are competitive from 100 K. The model further shows the different nature of the Au-Au and Au-C60 interactions inside the two unit cells, which makes one structure prevail over the other as a function of the experimental conditions. More specifically, the calyx-like structure of ref. [6] is favoured by metal-organic interactions, while the regular structure of ref. [5] is characterized by a remarkable stability of the Au surface. Poster ECSCD-8 18-21 July, 2004 (Segovia, Spain)

Background High-profile round saline breast implants that permit a better match of implant diameter to the base diameter of the breast are now available. Objective The advantages and disadvantages of high-profile breast implants are defined from the point of view of the author's initial experience. Methods The maximal optimal breast implant was determined on the basis of preoperative measurements, with emphasis on breast base diameter. Patients selected implant size using trial implants in a bra of the desired cup size. The implant profile with the best match to breast base diameter at the selected size range was used. Results Sixty-seven patients, of a total of 164 patients who received saline breast implants during a 14-month period, received high-profile breast implants. Conclusions High-profile saline implants provide a useful option for the patient who desires an implant size that exceeds the natural breast base diameter in standard profiles. Rippling may be diminished in these cases. A more conical shape may be achieved in cases of periareolar mastopexy with augmentation. Disadvantages of the high-profile design include less mobility of the implant and a less obtuse transition from the chest to the upper breast compared with results achieved with standard round implants.

Patients requesting nipple or areolar reduction often desire simultaneous breast augmentation. A technique is described for implant placement by means of a nipple base incision with either nipple reduction or intraareolar reduction. Nipple reduction is accomplished by removing a ring of skin from the base of the nipple, while areolar reduction is performed by removing a donut-shaped area of skin whose inner diameter is at the nipple base. The elasticity of the areolar skin allows for access for saline implant placement. The resulting scar is well concealed. Results from 15 patients demonstrate that the technique is safe, practical, and appears to pose no increased risk of sensory changes to the nipple.

This case report involving a 20-year-old male in the military serves as a reminder that not every individual presenting with musculoskeletal dysfunction has a simple uncomplicated musculoskeletal problem. Always consider acute exertional rhabdomyolysis (AER) as a differential diagnosis in patients who have performed intense exercise recently and are now complaining of muscle pain and weakness, especially if they have any of the AER risk factors discussed in this report (poor physical condition, exercising in a hot, humid environment, and poor fluid intake). These patients have an excellent prognosis if AER is caught early and treated aggressively. However, serious complications can occur if AER is overlooked or dismissed as delayed onset muscle soreness. J Orthop Sports Phys Ther. 2003;33(3):104–108.

Factorial experimental design.To compare the outcomes of 2 different abdominal muscular fitness training regimens on sit-up performance across sex and abdominal muscular fitness level.Researchers suggest that the curl-up, when compared to the sit-up, optimizes the challenge to the abdominal muscles while minimizing shear and compressive forces on the lumbar spine. Although researchers have compared curl-ups and sit-ups in many ways, a comparison of sit-up performance after training programs involving curl-ups and sit-ups has not been investigated.One hundred two active, healthy, college-aged subjects participated in this study. After stratification based upon maximal 2-minute sit-up performance during the orientation session, subjects were randomly assigned to either a training group using curl-up exercise, a training group using sit-up exercise, or a control group. Maximal 2-minute sit-up test performance was measured before and after a 6-week training program. Data were analyzed utilizing an ANOVA model. Significant interactions or main effects were analyzed utilizing Tukey's Honestly Significant Difference Test. Level of significance for all testing was at alpha = 0.05.The sit-up training group improved significantly (P0.05). No significant difference in sit-up performance was noted for the curl-up or control groups after the 6-week training program. No statistically significant difference in improvement was noted between sex of subject and level of abdominal muscular fitness of subject.Short-term sit-up training with the Modified Kersey Method in this population significantly improved a maximum 2-minute sit-up test performance. Curl-up training utilizing the same method did not result in improvement in the number of sit-ups performed in 2 minutes. Specificity of training provides the primary explanation for our findings.

Thin films of a benzylic amide macrocycle, the common component of a wide class of mechanically interlocked molecules, are prepared by vapor deposition on Au(111). The films are characterized by monochromated X-ray photoelectron spectroscopy (XPS) and high resolution electron energy loss spectroscopy (HREELS). The relative amounts of carbon, nitrogen, and oxygen are consistent with the formation of intact molecular species. At monolayer coverage, the relative intensity of out-of-plane to in-plane phenyl ring vibrational modes indicates that the macrocycle adopts a nearly flat-lying conformation. The formation of a chemisorption bond is evidenced by the presence of a Au-O stretching vibration and a low binding energy component in the O 1s core level region assigned to interfacial bonding. A decrease in film order and the absence of a preferred molecular orientation is observed at higher coverages. Computer modeling of the adsorption of the macrocycle on the surface rationalizes the experimental observations.

An approach to abdominoplasty has been developed incorporating a series of key surgical maneuvers designed to minimize complications while controlling scar position and eliminating the need for long-term drains. These include sharp defatting of the layer deep to the superficial fascia, progressive tension anchor sutures from the flap to the rectus sheath, and anchor sutures from the superficial fascia to the deep fascia along the line of closure. A retrospective review shows that the rate of postoperative seromas decreased from 33% to 6% with the use of anchor sutures from the flap to the deep fascia.

Background: In spite of the increasing popularity of ultrasound-assisted lipoplasty (UAL), questions remain about the effects of ultrasound energy on soft tissues, indications for the technique, and parameters for safe application and optimal results. Objective: This study was undertaken to evaluate the tissue effects of UAL and to correlate those effects with parameters based on clinical experience. Methods: Histologic evaluation with standard histologic staining was done on abdominoplasty specimens treated with UAL on one side and standard liposuction on the opposite side in patients undergoing both abdominoplasty and UAL. Additionally, 100 consecutive patients treated with UAL were reviewed. Results: It was found that optimal results correlated with submaximal amplitude settings, loss of tissue resistance to probe movement, and change in color of the aspirate from pale yellow to pink or tan as end points for the application of ultrasound. Histologic evaluation revealed that these parameters were associated with minimal effect on connective tissues and blood vessels. Longer application times were associated with disruption of collagen and elastin structures. Conclusions: This study confirms that UAL is an effective and safe technique in experienced hands when attention is given to easily observed end points for application of ultrasound energy.

A battery of computerised tests and the classical Stroop test were administered to a group of 56 patients with DSM-III-R schizophrenia and 17 controls to explore the nature of the mental processes associated with the psychomotor poverty and disorganisation syndromes. In patients with persistent illness, psychomotor poverty was associated with slower responses in a two-choice guessing task in which the appropriate response was not dictated by the circumstances. This association was not observed in patients with remitting illness, providing neuropsychological support to the distinction between ‘negative’ and ‘deficit’ symptoms in schizophrenia. Disorganisation syndrome was associated with impaired performance in the classical Stroop test, as shown in previous studies, but not with impairment in a task which required suppression of processing of irrelevant aspects of a stimulus, nor with impairment in a task which required the suppressing of a primed but irrelevant non-verbal response. This suggests that the disorganisation syndrome might be associated with a specific difficulty in suppressing irrelevant verbal responses.

[This corrects the article DOI: 10.1371/journal.ppat.1005306.].

Giant omphalocele is a major clinical challenge for pediatric surgeons. Whereas small- to medium-sized defects can be repaired primarily, larger omphaloceles cannot be closed at birth because the liver and small bowel have lost the right of domain to the abdomen. Two divergent strategies have evolved for treating these giant defects: (1) use of a silon chimney with gradual reduction of the contents of the sac, and (2) initial nonoperative management (epithelialization) of the omphalocele followed by repair of the residual ventral hernia. In an 18-year retrospective study, we have reviewed our experience with these treatment methods. Ninety-four infants underwent treatment for omphalocele between 1975 and 1993. Primary closure (PC) was possible in 55 patients, silon chimney (SC) was used in 15, and 7 had nonoperative management (NM) with epithelialization. In the remaining 17 infants, surgery was believed to be inappropriate because of the lethality of their associated anomalies. Major (but potentially survivable) anomalies were present in 26% of PC, 13% of SC, and 71% of the NM group patients. The majority of the liver was present in 73% of SC- and 86% of NM-treated omphaloceles. There was a decrease in length of stay, time to enteral feeding, and mortality over the 18-year period. However, those patients whose defects could not be closed primarily had consistently longer hospital stays. This was particularly true for the SC patients. The decreased use of total parenteral nutrition seems to reflect a shift from SC to NM rather than a decrease in the interval to full enteral feeding in any given treatment group over time.(ABSTRACT TRUNCATED AT 250 WORDS)

Backward walking has been advocated as a method of maintaining cardiovascular conditioning in patients undergoing knee rehabilitation because it may decrease patellofemoral joint compressive forces. The primary purpose of this study was to determine the relationship between the rate of oxygen consumption (VO2) and backward walking speed. Twenty-five healthy males, aged 18-35 years, participated in this study. The rate of oxygen consumption and heart rate were measured at the backward walking speeds of 0.89, 1.12, 1.34, 1.56, and 1.79 m/sec (2.0, 2.5, 3.0, 3.5, and 4.0 miles/hour, respectively). Analysis revealed a direct, curvilinear relationship between VO2 and backward walking speed. This research provides information that can be used to prescribe a backward walking rehabilitation program which may be appropriate to maintain aerobic fitness levels during rehabilitation of patients with patellofemoral pain syndrome.

The use of acellular dermal matrices (ADMs) has become a useful adjunct to implant-based breast reconstruction and revision of the augmented breast. In both instances, the goal is replacement or reinforcement of thinned or missing tissues for implant support and control of the implant pocket. This article reviews the factors that contribute to periprosthetic tissue thinning, and the advantages and limitations of the use of ADMs for revision breast surgery and breast reconstruction. Proof of concept for the use of ADMs in the periprosthetic space is detailed from early clinical experience and histologic analysis documenting vascular ingrowth and cellular repopulation.

High-intensity focused ultrasound presents a noninvasive approach to body sculpting for nonobese patients. The purpose of this study was to evaluate the safety and effectiveness of a high-intensity focused ultrasound device for sculpting of the abdomen and flanks.Adults (aged 18 to 65 years) with subcutaneous abdominal fat greater than or equal to 2.5 cm thick who met screening criteria were randomized to receive high-intensity focused ultrasound treatment of the anterior abdomen and flanks at energy levels (a total of three passes each) of 47 J/cm (141 J/cm total), 59 J/cm (177 J/cm), or 0 J/cm (no energy applied, sham control). The primary endpoint was change from baseline waist circumference at the iliac crest level at posttreatment week 12. Subjective aesthetic assessments included the Global Aesthetic Improvement Scale and a patient satisfaction questionnaire. Safety assessments included adverse events, laboratory values, and physical examinations.For the primary endpoint, in the intent-to-treat population, statistical significance versus sham was achieved for the 59-J/cm (-2.44; p = 0.01) but not the 47-J/cm treatment group (-2.06 cm; p = 0.13). In a per-protocol population, statistical significance versus sham was achieved for both the 59-J/cm (-2.52 cm; p = 0.002) and the 47-J/cm treatment groups (-2.10 cm; p = 0.04). Investigator subjective measures of global aesthetic improvement and patient satisfaction also favored each active treatment versus sham. Adverse events included mild to moderate discomfort, bruising, and edema. Laboratory values and physical examinations were unremarkable.Treatment with this high-intensity focused ultrasound device reduced waist circumference and was generally well tolerated for noninvasive body sculpting. Reduction in waist circumference was statistically significant with both active treatments (per protocol).Therapeutic, II.(Figure is included in full-text article.).

The subpectoral technique [1] and systematic analysis ofsoft tissue characteristics [2] have resulted in a more pre-dictable approach to breast implant surgery, yet certainproblems receive scant attention. Among these problemsare animation distortions and shape issues such as ‘‘double-bubble’’ deformity.In 2004, I reported the split-muscle technique as anoption that balances factors such as the need for coveragein thin or athletic women who want to avoid breast dis-tortion with physical activity [3]. Use of the split-muscletechnique in a large series also has been reported byKhan [4], with good outcomes and no significant animationproblems. Conversely, a recent survey by Spear et al. [5]found an overall incidence of 77.5% for some degree ofdistortion with subpectoral augmentation, rated as moder-ate or severe by 15% of patients. Considering that morethan 350,000 augmentation cases occur annually in theUnited States [6], most of which are subpectoral, thisbecomes a significant issue.Another problem, the ‘‘double-bubble’’ deformity, maybe related. Although this contour defect generally corre-sponds to the original inframammary fold, particularly incases with a short preoperative distance from the areolarmargin to the inframammary fold, I have routinelyobserved termination of the pectoralis muscle into theanterior capsule at the level of the external groove, whichdefines the abnormality. This may be coincidental wherethe preoperative inframammary fold is high, but the dou-ble-bubble contour occasionally develops when the areolarmargin-to-fold distance is normal. This can easily beascertained by asking the patient to flex and then observingupward pull at the level of the external groove, a phe-nomenon called ‘‘windowshading’’ (Fig. 1a, b). When thepatient is at rest, this external indentation is manifestexternally as the ‘‘double bubble’’ and corresponds to theedge of the muscle where it transitions into the capsule.The aforementioned problems occur because the portionof the muscle originating from the rib cage typically isattached at or cephalad to the inframammary fold. There-fore, it must be divided in most cases, allowing its retrac-tion superiorly (Fig. 2a, b). By definition then, the dividededge of the muscle settles somewhere between the nipple–areolar complex and the inframammary fold, where it fuseswith the anterior capsule as it develops. Contraction of themuscle unavoidably exerts pull on the capsule (Fig. 3),tethered only at its medial transition to the sternal attach-ment. For this reason, conversion to the split-muscle planecan be a useful option in cases of double-bubble deformi-ties with animation.One of the primary indications for subpectoral place-ment is upper pole coverage, afforded by the portion of thepectoralis major originating from the sternum. The costalportion provides central coverage, in which a subfascial orsubglandular plane very often is adequate because of breasttissue, even when upper pole muscle coverage is desirable.For primary augmentation using the split-muscle tech-nique, the prepectoral fascia is elevated using electrocau-tery under direct vision up to a line from the axilla to thepoint at which the pectoralis transitions from the sternum tothe rib cage. The muscle fibers then are separated along thisline to elevate the superior portion of the muscle whileleaving the inferior portion undisturbed (Fig. 4). Implantdimensions determine how far toward the insertion themuscle should be split. If an observable tendency exists forthe superior portion of the muscle to retract, a few sutures

The previously underappreciated problem of periprosthetic atrophy has emerged. An inadequate capsular envelope is the common denominator contributing to a variety of problems. These include visible rippling, bottoming out, implant malposition, and perhaps symmastia. Although a thin capsule is not always the sole cause of these problems, recognizing it as an element of the underlying pathophysiology holds the key to correcting it. Intracapsular Alloderm grafting provides a versatile option for capsular reinforcement in cases of periprosthetic atrophy. While not especially challenging technically, precise planning and execution are required for optimal results. The grafts are long-lasting and appear to pose minimal risk.

Because the subfascial plane is not generally believed to contribute to the thickness of the soft tissue coverage, it has received less emphasis. For subglandular placement, trade-offs include a potentially less supportive envelope, visible rippling, and a less natural upper-pole contour compared with the submuscular plane. These considerations are balanced against ease of dissection and quick recovery. The subpectoral or “dual-plane” approach improves coverage and contours for many patients, but some patients will develop a dynamic deformity that occurs with muscle flexion. This is related to the requisite detachment of the costal portion of the muscle origin, so that the free edge of the muscle fuses with the anterior capsule. Additionally, muscle activity over time may contribute to implant malposition, in particular a wide intermammary space. The subfascial plane is a versatile option for breast augmentation and can be used with round implants by employing the split subpectoral/subfascial pocket.

Resveratrol, an antioxidant polyphenol from red wine, has been the subject of intense interest in recent years due to a range of unique anti-aging properties. These include cardiovascular benefits via increased nitric oxide production, down-regulation of vasoactive peptides, lowered levels of oxidized low-density lipoprotein, and cyclooxygenase inhibition; possible benefits on Alzheimer's disease by breakdown of beta-amyloid and direct effects on neural tissues; phytohormonal actions; anticancer properties via modulation of signal transduction, which translates into anti-initiation, antipromotion, and antiprogression effects; antimicrobial effects; and sirtuin activation, which is believed to be involved in the caloric restriction-longevity effect. Here we report a resveratrol-based skin care formulation, with 17 times greater antioxidant activity than idebenone. The role of resveratrol in prevention of photoaging is reviewed and compared with other antioxidants used in skin care products.

Public opinion is formed both by long-term developments and--at the other extreme--by single unanticipated events. This suggests that readers of opinion survey findings should note field interviewing dates and further determine what the news media have been reporting about relevant developments and events. Personal health and the cost of health care are high on the public's agenda; this is an important backdrop to a review of public attitudes and priorities related to health and the environment. What about the environment? Americans increasingly believe that we are not spending enough on environmental protection and improvement. The public thinks of environmentalists in a favorable light, and a very sizeable minority believe they have too little influence--the same number who feel it's "about right." Our surveys have shown that the more people perceive an environmental threat to their safety, well-being and health, the more they will want regulation or industry action to meet the threat. High on the public's anxiety list are hazardous wastes (especially their disposal) and the transport and use of toxic materials in manufacturing and processing, industrial accidents involving the release of pollutants, the leakage of chemical waste into the soil, and the pollution of water and air from industrial sources. Our data support the assumption that for the foreseeable future these and certain other ecological dangers will be seen as serious by large majorities of Americans. For example, even the safety of drinking water has slowly become more questionable in the public's mind.(ABSTRACT TRUNCATED AT 250 WORDS)

Acute inspanningsrabdomyolyse is een potentieel levensbedreigende aandoening. In deze casus worden de diagnose, medische behandeling en revalidatie van een 20-jarige man beschreven die zich 36 uur voor het ontstaan van de klachten honderd keer op verschillende manieren had opgedrukt. Na 73 dagen was de patient volledig hersteld. De casus illustreert dat patienten met inspanningsrabdomyolyse een uitstekende prognose hebben als de aandoening vroeg wordt ontdekt en agressief wordt behandeld.

Nonexperimental, retrospective design.This study was designed to compare clinical diagnostic accuracy (CDA) between physical therapists (PTs), orthopaedic surgeons (OSs), and nonorthopaedic providers (NOPs) at Keller Army Community Hospital on patients with musculoskeletal injuries (MSI) referred for magnetic resonance imaging (MRI).US Army PTs are frequently the first credentialed providers privileged to examine and diagnose patients with musculoskeletal injuries. Physical therapists assigned at Keller Army Community Hospital have also been credentialed with privileges to order MRI studies for several years.To reduce provider bias, a retrospective analysis was performed on 560 patients referred for MRI over an 18-month period. An electronic review of each patient's radiological profile was performed to assess agreement between clinical diagnosis and MRI findings. Data analyses were performed through descriptive statistics and contingency tables.Analysis on agreement between clinical diagnosis and MRI findings produced a CDA of 74.5% (108/145) for PTs, 80.8% (139/172) for OSs, and 35.4% (86/243) for NOPs. There was a significant difference in CDA between PTs and NOPs (P.001), and between OSs and NOPs (P.001). There was no difference in CDA between PTs and OSs (P.05).Clinical diagnostic accuracy by PTs and OSs on patients with musculoskeletal injuries was significantly greater than for NOPs, with no difference noted between PTs and OSs.

Despite advances in surgical techniques and breast implant design, certain problems unique to breast implant surgery remain. The historically most onerous problem, capsular contracture, is relatively uncommon now. However, problems related to thin capsules and periprosthetic atrophy are becoming more common; these problems include rippling, symmastia, implant malposition, and bottoming out. Options for treatment of these conditions remain extremely limited, particularly with saline implants. Allogenic dermal grafting provides one satisfactory option. Techniques for use of allogenic dermal grafts and early results from 10 patients are summarized in this article, along with histologic analysis confirming viability of the grafts at 6-month follow-up in one patient. No graft-related complications were identified.

The events of 11 September 2001 were not the first acts of global terrorism, hut the effects were certainly felt by more nations than any previous terrorist act. The statements by President Bush in November 2001 made it clear that the United States will take any and all actions necessary to rid the world of terrorists with global reach. This war has in a sense become an unlimited war. The approach taken by the United States in response to the attacks has taken us down a road that may or may not reach the stated end state in the National Strategy for Combating Terrorism. An alternative approach, one that is more asymmetric in thought may have taken us to the end state in a timelier manner. However, without a properly defined end state it is difficult for Combatant Commanders to reverse plan. The National Strategy for Combating Terrorism is a sound document from which to start but some changes may he necessary. Additionally, without definitive measures of success it will he difficult to reach the end state. Since the first steps down the path to defeating terrorism have already been taken it is now time to ensure that the future actions are directed toward the root cause of the problem. Otherwise, the likelihood of the terrorist movement, its recruiting base, will continue to flow.

We wanted to investigate the utility of performing fiberoptic bronchoscopy before bronchial artery embolization in patients with massive hemoptysis.We retrospectively reviewed the cases of all patients with hemoptysis who had presented at either of two local hospitals, one county hospital and one community hospital, between 1988 and 2000 and who had undergone fiberoptic bronchoscopy before bronchial arteriography. All data were abstracted using a standardized coding form, and radiographs were independently reviewed by two of the authors.Twenty-nine patients meeting the inclusion criteria were identified; one patient was excluded because of missing radiographs. The remaining 28 patients consisted of 19 men and nine women, with an average age of 54.6 years (age range, 16-91 years). The clinically determined diagnoses of their symptoms were tuberculous bronchiectasis (n = 14; 50.0%); bronchogenic carcinoma (n = 4; 14.3%); active tuberculosis (n = 2; 7.1%); nontuberculous bronchiectasis (n = 2; 7.1%); active coccidioidomycosis, pancreaticobronchial fistula, arteriovenous malformation, and tetralogy of fallot (n =1 each; 3.6% each); and unknown cause (n = 2; 7.1%). The bleeding site determined through bronchoscopy was consistent with that determined through radiographs in 23 patients (82.1%); all had either unilateral disease (n = 15), bilateral disease with unilateral cavities (n = 5), or a preponderance of disease on one side (n = 3). Bronchoscopy was an essential tool in determining the bleeding site in only three patients (10.7%), all of whom had bronchiectasis without localizing features visible on chest radiographs. In the remaining two patients (7.1%), bronchoscopic findings were indeterminate, but radiographs were helpful.Fiberoptic bronchoscopy before bronchial artery embolization is unnecessary in patients with hemoptysis of known causation if the site of bleeding can be determined from radiographs and no bronchoscopic airways management is needed.

Improved techniques have enabled surgeons to perform large-volume liposuction more safely; however, the physiologic consequences of this procedure are not well documented. The possible effects of large-volume liposuction on serum lipids are not well established. This study was done to determine what changes, if any, occurred in serum lipid profiles in 10 consecutive large-volume (1860 to 4744 ml) liposuction cases. In 9 of 10 cases a decrease in the fasting serum cholesterol level was found at 2 months follow-up, averaging 9.5% ( p < 0.02). No consistent changes occurred in high-density lipoprotein/low-density lipoprotein ratios or triglycerides. This study confirms that fat reduction by liposuction affects fasting serum cholesterol levels.

The patient was an 11-year-old female referred to a physical therapist because of a primary complaint of progressively worsening left anterior knee pain of 9 months' duration. Examination of the patient's left knee was unremarkable and did not reproduce the patient's primary complaint. However, range-of-motion assessment of the patient's left hip elicited pain in the left anterior/medial hip region and revealed decreased hip internal rotation and abduction. Due to concern about the possibility of a slipped capital femoral epiphysis (SCFE), the patient was immediately referred to her physician, and subsequent radiographs revealed a left SCFE. J Orthop Sports Phys Ther 2012;42(5):482. doi:10.2519/jospt.2012.0408

The music video, as shown on Music Television (MTV), is a contemporary hybrid of rock music and film imagery. This study analyzed a sample of 62 MTV music videos in 23 content categories. Of the content categories studied, frequent occurrences were found in visual abstraction, sex, dance, violence, and crime. MTV sexual and violent content is characterized by innuendo and sug‐gestiveness, perhaps reflecting MTV's: adolescent audience appeal.

Aeronutronic Ford has developed a rugged, miniature, room temperature operable, gamma ray detector package containing a CdTe photon detector, a charge amplifier and a pulse shaper circuit. Photon detection efficiencies between 10% and 40% are achieved for various photon energies between 100 KEV and 1000 KEV in a detector area of .032 square inches. The resuling package weights ~8 grams and occupies ~0.1 cubic inch. Prototypes have been tested for aging and temperature effects on gamma detection efficiency. The intended application of the device is calibrated gamma ray counting in a warm environment while subjected to high intensity acoustic and vibration stresses as well as very large linear accelerations.