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11. Loss of ZnT8 function protects against diabetes by enhanced insulin secretion

Author

Dwivedi, Om Prakash, Lehtovirta, Mikko, Hastoy, Benoit, Chandra, Vikash, Krentz, Nicole A. J., Kleiner, Sandra, Jain, Deepak, Richard, Ann-Marie, Abaitua, Fernando, Beer, Nicola L., Grotz, Antje, Prasad, Rashmi B., Hansson, Ola, Ahlqvist, Emma, Krus, Ulrika, Artner, Isabella, Suoranta, Anu, Gomez, Daniel, Baras, Aris, Champon, Benoite, Payne, Anthony J., Moralli, Daniela, Thomsen, Soren K., Kramer, Philipp, Spiliotis, Ioannis, Ramracheya, Reshma, Chabosseau, Pauline, Theodoulou, Andria, Cheung, Rebecca, van de Bunt, Martijn, Flannick, Jason, Trombetta, Maddalena, Bonora, Enzo, Wolheim, Claes B., Sarelin, Leena, Bonadonna, Riccardo C., Rorsman, Patrik, Davies, Benjamin, Brosnan, Julia, McCarthy, Mark I., Otonkoski, Timo, Lagerstedt, Jens O., Rutter, Guy A., Gromada, Jesper, Gloyn, Anna L., Tuomi, Tiinamaija, and Groop, Leif

Published
2019
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18. Integrating tools for non-targeted analysis research and chemical safety evaluations at the US EPA

Author

Sobus, Jon, Wambaugh, John, Isaacs, Kristin, Williams, Antony, McEachran, Andrew, Richard, Ann, Grulke, Christopher, Ulrich, Elin, Rager, Julia, Strynar, Mark, and Newton, Seth

Abstract

Tens-of-thousands of chemicals are registered in the U.S. for use in countless processes and products. Recent evidence suggests that many of these chemicals are measureable in environmental and/or biological systems, indicating the potential for widespread exposures. Traditional public health research tools, including in vivo studies and targeted analytical chemistry methods, have been unable to meet the needs of screening programs designed to evaluate chemical safety. As such, new tools have been developed to enable rapid assessment of potentially harmful chemical exposures and their attendant biological responses. One group of tools, known as “non-targeted analysis” (NTA) methods, allows the rapid characterization of thousands of never-before-studied compounds in a wide variety of environmental, residential, and biological media. This article discusses current applications of NTA methods, challenges to their effective use in chemical screening studies, and ways in which shared resources (e.g., chemical standards, databases, model predictions, and media measurements) can advance their use in risk-based chemical prioritization. A brief review is provided of resources and projects within EPA’s Office of Research and Development (ORD) that provide benefit to, and receive benefits from, NTA research endeavors. A summary of EPA’s Non-Targeted Analysis Collaborative Trial (ENTACT) is also given, which makes direct use of ORD resources to benefit the global NTA research community. Finally, a research framework is described that shows how NTA methods will bridge chemical prioritization efforts within ORD. This framework exists as a guide for institutions seeking to understand the complexity of chemical exposures, and the impact of these exposures on living systems.

Published
2024
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19. Evaluation of Per- and Polyfluoroalkyl Substances (PFAS) In Vitro Toxicity Testing for Developmental Neurotoxicity

Author

Carstens, Kelly E., primary, Freudenrich, Theresa, additional, Wallace, Kathleen, additional, Choo, Seline, additional, Carpenter, Amy, additional, Smeltz, Marci, additional, Clifton, Matthew S., additional, Henderson, W. Matthew, additional, Richard, Ann M., additional, Patlewicz, Grace, additional, Wetmore, Barbara A., additional, Paul Friedman, Katie, additional, and Shafer, Timothy, additional

Published
2023
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26. Evaluation of Per- and Poly fluoroalkyl Substances (PFAS) in vitro toxicity testing for developmental neurotoxicity (SOT 23)

Author

Carstens, Kelly, Freudenrich, Theresa, Wallace, Kathleen, Choo, Seline, Carpenter, Amy, Richard, Ann, Patlewicz, Grace, Wetmore, Barbara, Paul Friedman, Katie, and Shafer, Timothy

Subjects
Toxicology (incl. clinical toxicology)
Abstract

Poster to be presented to the Society of Toxicology 62nd Annual Meeting and ToxExpo March 2023 Search for CCTE records in EPA’s Science Inventory by typing in the title at this link. https://cfpub.epa.gov/si/si_public_search_results.cfm?advSearch=true&showCriteria=2&keyword=CCTE&TIMSType=&TIMSSubTypeID=&epaNumber=&ombCat=Any&dateBeginPublishedPresented=07/01/2017&dateEndPublishedPresented=&dateBeginUpdated=&dateEndUpdated=&DEID=&personName=&personID=&role=Any&journalName=&journalID=&publisherName=&publisherID=&sortBy=pubDate&count=25

Published
2023
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27. Cross-Laboratory Comparison of Non-Targeted Analysis Method Performance using Complex Synthetic Mixtures

Author

Sobus, Jon, Phillips, Katherine, Grossman, Jarod, Chao, Alex, Williams, Antony, Grulke, Christopher, Richard, Ann, McEachran, Andrew, and Ulrich, Elin

Subjects
Toxicology (incl. clinical toxicology)
Abstract

Presentation to Pittcon on March 18-22, 2023 in Philadelphia, PA Science Inventory, CCTE products: https://cfpub.epa.gov/si/si_public_search_results.cfm?advSearch=true&showCriteria=2&keyword=CCTE&TIMSType=&TIMSSubTypeID=&epaNumber=&ombCat=Any&dateBeginPublishedPresented=07/01/2017&dateEndPublishedPresented=&dateBeginUpdated=&dateEndUpdated=&DEID=&personName=&personID=&role=Any&journalName=&journalID=&publisherName=&publisherID=&sortBy=pubDate&count=25

Published
2023
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28. Evaluation of Per- and Poly fluoroalkyl Substances (PFAS) in vitro toxicity testing for developmental neurotoxicity

Author

Carstens, Kelly, Freudenrich, Theresa, Wallace, Kathleen, Choo, Seline, Carpenter, Amy, Richard, Ann, Patlewicz, Grace, Wetmore, Barbara, Paul-Friedman, Katie, and Shafer, Timothy

Subjects
Toxicology (incl. clinical toxicology)
Abstract

Presentation to the American Society for Cellular and Computational Toxicology (ASCCT) Conference October 2022 Search for CCTE records in EPA’s Science Inventory by typing in the title at this link. https://cfpub.epa.gov/si/si_public_search_results.cfm?advSearch=true&showCriteria=2&keyword=CCTE&TIMSType=&TIMSSubTypeID=&epaNumber=&ombCat=Any&dateBeginPublishedPresented=07/01/2017&dateEndPublishedPresented=&dateBeginUpdated=&dateEndUpdated=&DEID=&personName=&personID=&role=Any&journalName=&journalID=&publisherName=&publisherID=&sortBy=pubDate&count=25

Published
2023
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32. SARS-CoV-2 infection is associated with post-acute self-reported neurocognitive symptoms

Author

PMB, Infectious Disease Clinical Research Program (IDCRP), Liana R. Andronescu, Stephanie A. Richard, Ann I. Scher, David A. Lindholm, Katrin Mende, Anuradha Ganesan, Nikhil Huprikar, Tahaniyat Lalani, Alfred Smith, Rupal M. Mody, Milissa U. Jones, Samantha E. Bazan, Rhonda E. Colombo, Christopher J. Colombo, Evan Ewers, Derek T. Larson, Ryan C. Maves, Catherine M. Berjohn, Carlos J Maldonado, Caroline English, Margaret Sanchez Edwards, Julia S. Rozman, Jennifer Rusiecki, Celia Byrne, Mark P. Simons, David Tribble, Timothy H Burgess, Simon D. Pollett, Brian K. Agan, PMB, Infectious Disease Clinical Research Program (IDCRP), Liana R. Andronescu, and Stephanie A. Richard, Ann I. Scher, David A. Lindholm, Katrin Mende, Anuradha Ganesan, Nikhil Huprikar, Tahaniyat Lalani, Alfred Smith, Rupal M. Mody, Milissa U. Jones, Samantha E. Bazan, Rhonda E. Colombo, Christopher J. Colombo, Evan Ewers, Derek T. Larson, Ryan C. Maves, Catherine M. Berjohn, Carlos J Maldonado, Caroline English, Margaret Sanchez Edwards, Julia S. Rozman, Jennifer Rusiecki, Celia Byrne, Mark P. Simons, David Tribble, Timothy H Burgess, Simon D. Pollett, Brian K. Agan

Abstract

Background Correspondence SARS-CoV-2 infection is associated with post-acute self-reported neurocognitive symptoms Liana R. Andronescu, PhD, MPH1,2, Stephanie A. Richard, PhD, MHS 1,2, Ann I. Scher, PhD3, David A. Lindholm, MD4,5, Katrin Mende, PhD1,2,5, Anuradha Ganesan, MBBS, MPH1,2,6, Nikhil Huprikar MD6, Tahaniyat Lalani, MBBS, MHS1,2,7, Alfred Smith MD7, Rupal M. Mody, MD8, Milissa U. Jones, MD9, Samantha E. Bazan, DNP, MS10, Rhonda E. Colombo, MD, MHS1,2,4,11, Christopher J. Colombo, MD4,11, Evan Ewers12, Derek T. Larson, DO12,13, Ryan C. Maves, MD1,13, Catherine M. Berjohn, MD, MPH1,4,13, Carlos J Maldonado, PhD14, Caroline English1,2, Margaret Sanchez Edwards, MS1,2, Julia S. Rozman, BS1,2, Jennifer Rusiecki, PhD3, Celia Byrne, PhD3, Mark P. Simons, PhD1, David Tribble, MD, DrPH1, Timothy H Burgess, MD, MPH1, Simon D. Pollett, MBBS1,2, Brian K. Agan, MD1,2 Objectives Chronic neuropsychological sequelae following SARS-CoV-2 infection, including depression, anxiety, fatigue, and general cognitive difficulties, are a major public health concern. Given the potential impact of long-term neurocognitive impairment on active-duty service members and other Military Health System (MHS) beneficiaries, it is important to characterize this post-infection phenotype and assess potential risk factors for poor neurocognitive outcomes. Email: landronescu@idcrp.org; liana.andronescu.ctr@usuhs.edu USU Infectious Disease Clinical Research Program (IDCRP), Department of Preventive Medicine and Biostatistics Henry M. Jackson Foundation for the Advancement of Military Medicine • Describe the prevalence of self-reported neurocognitive symptoms among SARS-CoV-2 positive vs negative subjects • Identify risk factors for self-reported neurocognitive symptoms among SARS-CoV-2 positive subjects Results 1Infectious Disease Clinical Research Program, Department of Preventive Medicine and Biostatistics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA; 2Henry M. Jackso, RITM0027659, Chronic neuropsychological sequelae following SARS-CoV-2 infection, including depression, anxiety, fatigue, and general cognitive difficulties, are a major public health concern. Given the potential impact of long-term neurocognitive impairment on active-duty service members and other Military Health System (MHS) beneficiaries, it is important to characterize this post-infection phenotype and assess potential risk factors for poor neurocognitive outcomes.

Published
2022

36. Defining the Cutting-Edge to the US EPA's Computational Exposure Science

Author

Buckley, Timothy, Biales, Adam, Egeghy, Peter, Richard, Ann, Sobus, Jon, Ulrich, Elin, Isaacs, Kristin, Wambaugh, John, Ring, Caroline, Sayre, Risa, Purucker, Tom, Williams, Antony, and Thomas, Russell

Subjects
Toxicology (incl. clinical toxicology)
Abstract

Presentation to ISES on Sept. 25-29, 2022 in Lisbon, Portugal Science Inventory, CCTE products: https://cfpub.epa.gov/si/si_public_search_results.cfm?advSearch=true&showCriteria=2&keyword=CCTE&TIMSType=&TIMSSubTypeID=&epaNumber=&ombCat=Any&dateBeginPublishedPresented=07/01/2017&dateEndPublishedPresented=&dateBeginUpdated=&dateEndUpdated=&DEID=&personName=&personID=&role=Any&journalName=&journalID=&publisherName=&publisherID=&sortBy=pubDate&count=25

Published
2022
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37. EPA’s DSSTox Database: The strategic role and requirements of chemical curation

Author

Richard, Ann

Subjects
Toxicology (incl. clinical toxicology)
Abstract

Presentation for Cheminformatics Resources of US Governmental Organizations Workshop (Food and Drug Administration) on May 9, 2022 (Virtual) Science Inventory, CCTE products: https://cfpub.epa.gov/si/si_public_search_results.cfm?advSearch=true&showCriteria=2&keyword=CCTE&TIMSType=&TIMSSubTypeID=&epaNumber=&ombCat=Any&dateBeginPublishedPresented=07/01/2017&dateEndPublishedPresented=&dateBeginUpdated=&dateEndUpdated=&DEID=&personName=&personID=&role=Any&journalName=&journalID=&publisherName=&publisherID=&sortBy=pubDate&count=25

Published
2022
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38. Cheminformatics approaches supporting UVCB chemical representation in the US-EPA CompTox Chemicals Dashboard

Author

Williams, Antony, Sinclair, Gabriel, Thillainadarajah, inthirany, Meyer, Brian, Samano, Vicente, and Richard, Ann

Subjects
Toxicology (incl. clinical toxicology)
Abstract

Presentation to Fall ACS on August 21-25, 2022 in Chicago IL Science Inventory, CCTE products: https://cfpub.epa.gov/si/si_public_search_results.cfm?advSearch=true&showCriteria=2&keyword=CCTE&TIMSType=&TIMSSubTypeID=&epaNumber=&ombCat=Any&dateBeginPublishedPresented=07/01/2017&dateEndPublishedPresented=&dateBeginUpdated=&dateEndUpdated=&DEID=&personName=&personID=&role=Any&journalName=&journalID=&publisherName=&publisherID=&sortBy=pubDate&count=25

Published
2022
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39. Benchmarking novel curation strategies for large publicly available water solubility compilations

Author

Lowe, Charles, Charest, Nathaniel, Ramsland, Christian, Martin, Todd, Richard, Ann, and Williams, Antony

Subjects
Toxicology (incl. clinical toxicology)
Abstract

Presentation for Fall ACS in August 21-25, 2022 in Chicago IL Science Inventory, CCTE products: https://cfpub.epa.gov/si/si_public_search_results.cfm?advSearch=true&showCriteria=2&keyword=CCTE&TIMSType=&TIMSSubTypeID=&epaNumber=&ombCat=Any&dateBeginPublishedPresented=07/01/2017&dateEndPublishedPresented=&dateBeginUpdated=&dateEndUpdated=&DEID=&personName=&personID=&role=Any&journalName=&journalID=&publisherName=&publisherID=&sortBy=pubDate&count=25 KEYWORDS: ben

Published
2022
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40. A Vision for Next Generation Risk Assessment at the U.S. Environmental Protection Agency

Author

Wambaugh, John, Friedman, Katie Paul, Harrill, Alison, Isaacs, Kristin, Buckley, Timothy, Cowden, John, Deisenroth, Chad, DeVito, Michael, Egeghy, Peter, Harrill, Joshua, Hunter, Sid, Judson, Richard, Richard, Ann, Ring, Caroline, Sayre, Risa, Singh, Amar, Sobus, Jon, Ulrich, Elin, Wetmore, Barbara, Williams, Antony, and Thomas, Russell

Subjects
Toxicology (incl. clinical toxicology)
Abstract

Presentation to RISK-HUNT3R Face-to-Face Kickoff Meeting on July 5-7, 2022 in the Netherlands Science Inventory, CCTE products: https://cfpub.epa.gov/si/si_public_search_results.cfm?advSearch=true&showCriteria=2&keyword=CCTE&TIMSType=&TIMSSubTypeID=&epaNumber=&ombCat=Any&dateBeginPublishedPresented=07/01/2017&dateEndPublishedPresented=&dateBeginUpdated=&dateEndUpdated=&DEID=&personName=&personID=&role=Any&journalName=&journalID=&publisherName=&publisherID=&sortBy=pubDate&count=25

Published
2022
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41. EPA’s DSSTox Database: The strategic role and requirements of chemical curation

Author

Richard, Ann M.

Abstract

The expansion of chemical-bioassay data in the public domain is a boon to science; however, inaccuracies in linkages of CAS registry number (CASRN) to structure, and unreliability of names and synonyms assigned to a particular structure are well known. EPA’s DSSTox project, through strategic use of expert manual curation and strict enforcement of database rules, has earned a reputation for providing quality chemical-structure annotations to the environmental toxicology community. The DSSTox database, supported by modern cheminformatics tools, has grown to contain more than 1.2 million unique chemical records, and provides the underpinning for EPA’s CompTox Chemicals Dashboard that uses chemical structure to link diverse data streams and resources in support of EPA’s chemical research and regulatory programs. A history of DSSTox’s expansion from 25K to over 1million substances, while retaining a focus on quality chemical associations, is presented, with a particular focus on the critical role of expert manual curation, how and when this resource is implemented and applied, and the impact of expert curation on real Agency problems. Examples include: curation of more than 10,000 per- and poly-fluorinated alkyl substances (PFAS) structures and over 1000 Markush-type structures to represent ill-defined PFAS substances; curation of ToxCast and Tox21 sample libraries supporting EPA’s high-throughput testing programs; and creation of reference libraries in support of non-targeted screening objectives. Whereas other large public chemical databases also employ automated chemical curation approaches to address quality issues, the DSSTox project owes its reputation for quality to the necessary and strategic use of expert manual curation. This abstract does not reflect U.S. EPA policy.

Published
2022
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42. Comparison of list of per- and polyfluoroalkyl substances (PFAS) based on different definitions

Author

Williams, Antony, Gaines, Linda, Sinclair, Gabriel, Lowe, Charles, Thillainadarajah, Inthirany, Meyer, Brian, Patlewicz, Grace, and Richard, Ann

Subjects
Toxicology (incl. clinical toxicology)
Abstract

Presentation to Fall ACS on August 21-25, 2022 in Chicago IL Science Inventory, CCTE products: https://cfpub.epa.gov/si/si_public_search_results.cfm?advSearch=true&showCriteria=2&keyword=CCTE&TIMSType=&TIMSSubTypeID=&epaNumber=&ombCat=Any&dateBeginPublishedPresented=07/01/2017&dateEndPublishedPresented=&dateBeginUpdated=&dateEndUpdated=&DEID=&personName=&personID=&role=Any&journalName=&journalID=&publisherName=&publisherID=&sortBy=pubDate&count=25

Published
2022
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44. Structured extraction of comprehensive chemical data from Wikipedia

Author

Sinclair, Gabriel, Thillainadarajah, Inthirany, Meyer, Brian, Samano, Vicente, Sivasupramaniam, Sakuntala, Adams, Linda, Richard, Ann, and Williams, Antony

Subjects
Toxicology (incl. clinical toxicology)
Abstract

Presentation to Fall ACS on August 21-25, 2022 in Chicago IL Science Inventory, CCTE products: https://cfpub.epa.gov/si/si_public_search_results.cfm?advSearch=true&showCriteria=2&keyword=CCTE&TIMSType=&TIMSSubTypeID=&epaNumber=&ombCat=Any&dateBeginPublishedPresented=07/01/2017&dateEndPublishedPresented=&dateBeginUpdated=&dateEndUpdated=&DEID=&personName=&personID=&role=Any&journalName=&journalID=&publisherName=&publisherID=&sortBy=pubDate&count=25

Published
2022
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45. Benchmarking novel curation strategies for large publicly available water solubility compilations

Author

Sinclair, Gabriel, Lowe, Charles, Charest, Nathaniel, Ramsland, Christian, Martin, Todd, Richard, Ann, and Williams, Antony

Subjects
Toxicology (incl. clinical toxicology)
Abstract

Presentation for Fall ACS in August 21-25, 2022 in Chicago IL Science Inventory, CCTE products: https://cfpub.epa.gov/si/si_public_search_results.cfm?advSearch=true&showCriteria=2&keyword=CCTE&TIMSType=&TIMSSubTypeID=&epaNumber=&ombCat=Any&dateBeginPublishedPresented=07/01/2017&dateEndPublishedPresented=&dateBeginUpdated=&dateEndUpdated=&DEID=&personName=&personID=&role=Any&journalName=&journalID=&publisherName=&publisherID=&sortBy=pubDate&count=25

Published
2022
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