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15 results on '"Ricci, Liviana"'

1. Coffee consumption is associated with intestinal Lawsonibacter asaccharolyticus abundance and prevalence across multiple cohorts

Author

Manghi, Paolo, Bhosle, Amrisha, Wang, Kai, Marconi, Roberta, Selma-Royo, Marta, Ricci, Liviana, Asnicar, Francesco, Golzato, Davide, Ma, Wenjie, Hang, Dong, Thompson, Kelsey N., Franzosa, Eric A., Nabinejad, Amir, Tamburini, Sabrina, Rimm, Eric B., Garrett, Wendy S., Sun, Qi, Chan, Andrew T., Valles-Colomer, Mireia, Arumugam, Manimozhiyan, Bermingham, Kate M., Giordano, Francesca, Davies, Richard, Hadjigeorgiou, George, Wolf, Jonathan, Strowig, Till, Berry, Sarah E., Huttenhower, Curtis, Spector, Tim D., Segata, Nicola, and Song, Mingyang

Published
2024
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4. The person-to-person transmission landscape of the gut and oral microbiomes

Author

Valles-Colomer, Mireia, Blanco-Míguez, Aitor, Manghi, Paolo, Asnicar, Francesco, Dubois, Leonard, Golzato, Davide, Armanini, Federica, Cumbo, Fabio, Huang, Kun D., Manara, Serena, Masetti, Giulia, Pinto, Federica, Piperni, Elisa, Punčochář, Michal, Ricci, Liviana, Zolfo, Moreno, Farrant, Olivia, Goncalves, Adriana, Selma-Royo, Marta, Binetti, Ana G., Becerra, Jimmy E., Han, Bei, Lusingu, John, Amuasi, John, Amoroso, Loredana, Visconti, Alessia, Steves, Claire M., Falchi, Mario, Filosi, Michele, Tett, Adrian, Last, Anna, Xu, Qian, Qin, Nan, Qin, Huanlong, May, Jürgen, Eibach, Daniel, Corrias, Maria Valeria, Ponzoni, Mirco, Pasolli, Edoardo, Spector, Tim D., Domenici, Enrico, Collado, Maria Carmen, and Segata, Nicola

Published
2023
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9. The person-to-person transmission landscape of the gut and oral microbiomes

Author

European Commission, National Cancer Institute (US), European Research Council, Simons Foundation, EMBO, 0000-0002-1988-6054, 0000-0001-7386-5572, 0000-0003-0846-6529, 0000-0003-3732-1468, 0000-0001-6371-528X, 0000-0002-4539-4811, 0000-0001-9450-9235, 0000-0001-6661-4046, 0000-0001-5212-1101, 0000-0002-8640-2662, 0000-0003-4144-2019, 0000-0002-5646-1004, 0000-0002-3872-347X, 0000-0002-7623-217X, 0000-0002-9128-9414, 0000-0001-8438-2322, 0000-0001-7831-8420, 0000-0002-7316-0772, 0000-0002-9795-0365, 0000-0001-7436-6919, 0000-0002-1583-5794, Valles-Colomer, Mireia, Blanco-Míguez, Aitor, Manghi, Paolo, Asnicar, Francesco, Dubois, Leonard, Golzato, Davide, Armanini, Federica, Cumbo, Fabio, Huang, Kun D., Manara, Serena, Masetti, Giulia, Pinto, Federica, Piperni, Elisa, Punčochář, Michal, Ricci, Liviana, Zolfo, Moreno, Farrant, Olivia, Goncalves, Adriana, Selma-Royo, Marta, Binetti, Ana G., Becerra, Jimmy E., Han, Bei, Lusingu, John, Amuasi, John, Amoroso, Loredana, Visconti, Alessia, Steves, Claire M., Falchi, Mario, Filosi, Michele, Tett, Adrian, Last, Anna, Xu, Qian, Qin, Nan, Qin, Huanlong, May, Jürgen, Eibach, Daniel, Corrias, Maria Valeria, Ponzoni, Mirco, Pasolli, Edoardo, Spector, Tim D., Domenici, Enrico, Collado, María Carmen, Segata, Nicola, European Commission, National Cancer Institute (US), European Research Council, Simons Foundation, EMBO, 0000-0002-1988-6054, 0000-0001-7386-5572, 0000-0003-0846-6529, 0000-0003-3732-1468, 0000-0001-6371-528X, 0000-0002-4539-4811, 0000-0001-9450-9235, 0000-0001-6661-4046, 0000-0001-5212-1101, 0000-0002-8640-2662, 0000-0003-4144-2019, 0000-0002-5646-1004, 0000-0002-3872-347X, 0000-0002-7623-217X, 0000-0002-9128-9414, 0000-0001-8438-2322, 0000-0001-7831-8420, 0000-0002-7316-0772, 0000-0002-9795-0365, 0000-0001-7436-6919, 0000-0002-1583-5794, Valles-Colomer, Mireia, Blanco-Míguez, Aitor, Manghi, Paolo, Asnicar, Francesco, Dubois, Leonard, Golzato, Davide, Armanini, Federica, Cumbo, Fabio, Huang, Kun D., Manara, Serena, Masetti, Giulia, Pinto, Federica, Piperni, Elisa, Punčochář, Michal, Ricci, Liviana, Zolfo, Moreno, Farrant, Olivia, Goncalves, Adriana, Selma-Royo, Marta, Binetti, Ana G., Becerra, Jimmy E., Han, Bei, Lusingu, John, Amuasi, John, Amoroso, Loredana, Visconti, Alessia, Steves, Claire M., Falchi, Mario, Filosi, Michele, Tett, Adrian, Last, Anna, Xu, Qian, Qin, Nan, Qin, Huanlong, May, Jürgen, Eibach, Daniel, Corrias, Maria Valeria, Ponzoni, Mirco, Pasolli, Edoardo, Spector, Tim D., Domenici, Enrico, Collado, María Carmen, and Segata, Nicola

Abstract

The human microbiome is an integral component of the human body and a co-determinant of several health conditions1,2. However, the extent to which interpersonal relations shape the individual genetic makeup of the microbiome and its transmission within and across populations remains largely unknown3,4. Here, capitalizing on more than 9,700 human metagenomes and computational strain-level profiling, we detected extensive bacterial strain sharing across individuals (more than 10 million instances) with distinct mother-to-infant, intra-household and intra-population transmission patterns. Mother-to-infant gut microbiome transmission was considerable and stable during infancy (around 50% of the same strains among shared species (strain-sharing rate)) and remained detectable at older ages. By contrast, the transmission of the oral microbiome occurred largely horizontally and was enhanced by the duration of cohabitation. There was substantial strain sharing among cohabiting individuals, with 12% and 32% median strain-sharing rates for the gut and oral microbiomes, and time since cohabitation affected strain sharing more than age or genetics did. Bacterial strain sharing additionally recapitulated host population structures better than species-level profiles did. Finally, distinct taxa appeared as efficient spreaders across transmission modes and were associated with different predicted bacterial phenotypes linked with out-of-host survival capabilities. The extent of microorganism transmission that we describe underscores its relevance in human microbiome studies5, especially those on non-infectious, microbiome-associated diseases.

Published
2023

10. Impact of changes at the Candida albicans cell surface upon immunogenicity and colonisation in the gastrointestinal tract

Author

Avelar, Gabriela M., primary, Dambuza, Ivy M., additional, Ricci, Liviana, additional, Yuecel, Raif, additional, Mackenzie, Kevin, additional, Childers, Delma S., additional, Bain, Judith M., additional, Pradhan, Arnab, additional, Larcombe, Daniel E., additional, Netea, Mihai G., additional, Erwig, Lars P., additional, Brown, Gordon D., additional, Duncan, Sylvia H., additional, Gow, Neil A.R., additional, Walker, Alan W., additional, and Brown, Alistair J.P., additional

Published
2022
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13. Human gut bifidobacteria inhibit the growth of the opportunistic fungal pathogen Candida albicans.

Author

Ricci, Liviana, Mackie, Joanna, Donachie, Gillian E, Chapuis, Ambre, Mezerová, Kristýna, Lenardon, Megan D, Brown, Alistair J P, Duncan, Sylvia H, and Walker, Alan W

Subjects
*CANDIDA albicans, *BIFIDOBACTERIUM, *FUNGAL growth, *SHORT-chain fatty acids, *HUMAN microbiota, *GUT microbiome
Abstract

The human gut microbiota protects the host from invading pathogens and the overgrowth of indigenous opportunistic species via a process called colonization resistance. Here, we investigated the antagonistic activity of human gut bacteria towards Candida albicans , an opportunistic fungal pathogen that can cause severe infections in susceptible individuals. Coculture batch incubations of C. albicans in the presence of faecal microbiota from six healthy individuals revealed varying levels of inhibitory activity against C. albicans. 16S rRNA gene amplicon profiling of these faecal coculture bacterial communities showed that the Bifidobacteriaceae family, and Bifidobacterium adolescentis in particular, were most correlated with antagonistic activity against C. albicans. Follow-up mechanistic studies performed under anaerobic conditions confirmed that culture supernatants of Bifidobacterium species, particularly B. adolescentis , inhibited C. albicans in vitro. Fermentation acids (FA), including acetate and lactate, present in the bifidobacterial supernatants were important contributors to inhibitory activity. However, increasing the pH of both bacterial supernatants and mixtures of FA reduced their anti- Candida effects, indicating a combinatorial effect of prevailing pH and FA. This work, therefore, demonstrates potential mechanisms underpinning gut microbiome-mediated colonization resistance against C. albicans , and identifies particularly inhibitory components such as bifidobacteria and FA as targets for further study. [ABSTRACT FROM AUTHOR]

Published
2022
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14. Bifidobacterium adolescentis shows potential to strengthen host defence against gastrointestinal infection via inhibition of the opportunistic pathogen Candida albicans and stimulation of human-isolated macrophages killing capacity in vitro

Author

Ricci, Liviana, primary, Mackie, Joanna, additional, Lenardon, Megan D., additional, Jukes, Caitlin, additional, Hegazy, Ahmed N., additional, Brown, Alistair J.P., additional, Duncan, Sylvia H., additional, and Walker, Alan W., additional

Published
2020
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15. The person-to-person transmission landscape of the gut and oral microbiomes

Author

Mireia Valles-Colomer, Aitor Blanco-Míguez, Paolo Manghi, Francesco Asnicar, Leonard Dubois, Davide Golzato, Federica Armanini, Fabio Cumbo, Kun D. Huang, Serena Manara, Giulia Masetti, Federica Pinto, Elisa Piperni, Michal Punčochář, Liviana Ricci, Moreno Zolfo, Olivia Farrant, Adriana Goncalves, Marta Selma-Royo, Ana G. Binetti, Jimmy E. Becerra, Bei Han, John Lusingu, John Amuasi, Loredana Amoroso, Alessia Visconti, Claire M. Steves, Mario Falchi, Michele Filosi, Adrian Tett, Anna Last, Qian Xu, Nan Qin, Huanlong Qin, Jürgen May, Daniel Eibach, Maria Valeria Corrias, Mirco Ponzoni, Edoardo Pasolli, Tim D. Spector, Enrico Domenici, Maria Carmen Collado, Nicola Segata, Valles-Colomer, Mireia, Blanco-Míguez, Aitor, Manghi, Paolo, Asnicar, Francesco, Dubois, Leonard, Golzato, Davide, Armanini, Federica, Cumbo, Fabio, Huang, Kun D, Manara, Serena, Masetti, Giulia, Pinto, Federica, Piperni, Elisa, Punčochář, Michal, Ricci, Liviana, Zolfo, Moreno, Farrant, Olivia, Goncalves, Adriana, Selma-Royo, Marta, Binetti, Ana G, Becerra, Jimmy E, Han, Bei, Lusingu, John, Amuasi, John, Amoroso, Loredana, Visconti, Alessia, Steves, Claire M, Falchi, Mario, Filosi, Michele, Tett, Adrian, Last, Anna, Xu, Qian, Qin, Nan, Qin, Huanlong, May, Jürgen, Eibach, Daniel, Corrias, Maria Valeria, Ponzoni, Mirco, Pasolli, Edoardo, Spector, Tim D, Domenici, Enrico, Collado, Maria Carmen, Segata, Nicola, European Commission, National Cancer Institute (US), European Research Council, Simons Foundation, and EMBO

Subjects
Multidisciplinary, Health, Metagenomes, Transmission, Interpersonal relations, Human microbiome
Abstract

The human microbiome is an integral component of the human body and a co-determinant of several health conditions1,2. However, the extent to which interpersonal relations shape the individual genetic makeup of the microbiome and its transmission within and across populations remains largely unknown3,4. Here, capitalizing on more than 9,700 human metagenomes and computational strain-level profiling, we detected extensive bacterial strain sharing across individuals (more than 10 million instances) with distinct mother-to-infant, intra-household and intra-population transmission patterns. Mother-to-infant gut microbiome transmission was considerable and stable during infancy (around 50% of the same strains among shared species (strain-sharing rate)) and remained detectable at older ages. By contrast, the transmission of the oral microbiome occurred largely horizontally and was enhanced by the duration of cohabitation. There was substantial strain sharing among cohabiting individuals, with 12% and 32% median strain-sharing rates for the gut and oral microbiomes, and time since cohabitation affected strain sharing more than age or genetics did. Bacterial strain sharing additionally recapitulated host population structures better than species-level profiles did. Finally, distinct taxa appeared as efficient spreaders across transmission modes and were associated with different predicted bacterial phenotypes linked with out-of-host survival capabilities. The extent of microorganism transmission that we describe underscores its relevance in human microbiome studies5, especially those on non-infectious, microbiome-associated diseases., This work was supported by the European Research Council (ERC-STG project MetaPG-716575 and ERC-CoG microTOUCH-101045015) to N.S. and by EMBO ALTF 593–2020 to M.V.-C. The work was also partially supported by MIUR ‘Futuro in Ricerca’ (grant no. RBFR13EWWI_001) to N.S., by the European H2020 programme (ONCOBIOME-825410 project, MASTER-818368 project, and IHMCSA-964590) to N.S., by the National Cancer Institute of the National Institutes of Health (1U01CA230551) to N.S., by the Premio Internazionale Lombardia e Ricerca 2019 to N.S., by the Simons Foundation (award ID 648614) to E.D. and N.S., and by the European Research Council (ERC-STG project Mami-639226) to M.C.C

Published
2023

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