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Healthcare involves complex decision making from planning to resource management. Resources in hospitals are usually allocated by experienced managers,however, due to an inherent process complexity, decisions are surrounded by uncertainties, variabilities, and constraints. Information Systems must be robust enough to provide support to stakeholders, capable of controlling and support work flows. The present work explores the required synergy when combining business processes with discrete event simulation. The objective is to estimate performance indices and address capacity management of a surgical center as a case study. Postprint