1. MetSCORE: a molecular metric to evaluate the risk of metabolic syndrome based on serum NMR metabolomics
- Author
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Rubén Gil-Redondo, Ricardo Conde, Chiara Bruzzone, Maria Luisa Seco, Maider Bizkarguenaga, Beatriz González-Valle, Angela de Diego, Ana Laín, Hansjörg Habisch, Christoph Haudum, Nicolas Verheyen, Barbara Obermayer-Pietsch, Sara Margarita, Serena Pelusi, Ignacio Verde, Nádia Oliveira, Adriana Sousa, Amaia Zabala-Letona, Aida Santos-Martin, Ana Loizaga-Iriarte, Miguel Unda-Urzaiz, Jasmin Kazenwadel, Georgy Berezhnoy, Tobias Geisler, Meinrad Gawaz, Claire Cannet, Hartmut Schäfer, Tammo Diercks, Christoph Trautwein, Arkaitz Carracedo, Tobias Madl, Luca Valenti, Manfred Spraul, Shelly C. Lu, Nieves Embade, José M. Mato, and Oscar Millet
- Subjects
Metabolic syndrome ,Lipoproteins ,Obesity ,Dyslipidemia ,Diabetes ,Hypertension ,Diseases of the circulatory (Cardiovascular) system ,RC666-701 - Abstract
Abstract Background Metabolic syndrome (MetS) is a cluster of medical conditions and risk factors correlating with insulin resistance that increase the risk of developing cardiometabolic health problems. The specific criteria for diagnosing MetS vary among different medical organizations but are typically based on the evaluation of abdominal obesity, high blood pressure, hyperglycemia, and dyslipidemia. A unique, quantitative and independent estimation of the risk of MetS based only on quantitative biomarkers is highly desirable for the comparison between patients and to study the individual progression of the disease in a quantitative manner. Methods We used NMR-based metabolomics on a large cohort of donors (n = 21,323; 37.5% female) to investigate the diagnostic value of serum or serum combined with urine to estimate the MetS risk. Specifically, we have determined 41 circulating metabolites and 112 lipoprotein classes and subclasses in serum samples and this information has been integrated with metabolic profiles extracted from urine samples. Results We have developed MetSCORE, a metabolic model of MetS that combines serum lipoprotein and metabolite information. MetSCORE discriminate patients with MetS (independently identified using the WHO criterium) from general population, with an AUROC of 0.94 (95% CI 0.920–0.952, p
- Published
- 2024
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