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The adoption of learning analytics (LA) in higher education institutions (HEIs) in Mexico is still at an early stage despite increasing global interest and advances in the field. The use of educational data remains a challenging puzzle for many universities, which strive to provide students, teachers, and institutional administrators with information and insights to better understand their performance. The objective of this study was to identify the perspectives of teachers, students, and administrators about the use of educational data to explore opportunities for the adoption and integration of LA in three different Mexican universities. A qualitative approach was used, adopting instruments and guidelines previously developed in the framework of Learning Analytics for Latin America (LALA) project, adapting them to the Mexican context. Methods included (1) structured interviews with high-level institutional administrators and (2) focus groups with students, teachers, and other educational administrators. Results showed that perceptions are oriented toward improving school performance through data-based feedback, with ethical responsibility. Emergent categories were physical and mental health, development of healthy relationships and well-being, feedback style, and governance in a bureaucratic setting. The specific modern construct of LA still needs to be internalized and disseminated to Mexican universities' educational stakeholders to increase the likelihood of successful adoption.

The Quintero-Puchuncaví Bay in Chile, has been affected by multiple episodes of anthropogenic contamination caused by companies in the Ventanas Industrial Corridor, making it one of the sacrifice zones in the country. On August 21, 2018, a mass poisoning of children and adolescents occurred, highlighting the dangers of contamination on the population's health at a national level. This qualitative narrative study explores this issue through the health trajectories of five families residing in the area. Information was gathered through family interviews, using art therapy strategies. A thematic narrative analysis of the data was conducted.The results reveal the presence of a range of illnesses spanning at least three generations of the interviewees' families. However, the long-term effects of contamination had not been fully acknowledged until the August 2018 incident, which made them aware of the generational transmission of normalizing this type of poisoning in their life paths. Additionally, the participants identify legal issues in controlling and reducing toxic emissions in the area.

Cholesterol is a molecule vital for tick physiology, but ticks cannot synthesize it and rely on dietary cholesterol. Therefore, tick proteins involved in cholesterol absorption and transport, such as the Niemann-Pick type C1 domain-containing (NPC1) proteins, are promising targets for anti-tick vaccine development. The aim of this study was to assess the structure, function, and protective efficacy of the NPC1 orthologues identified previously in the midgut transcriptomes of argasid ticks Ornithodoros erraticus and Ornithodoros moubata. For this purpose, their corresponding cDNA coding sequences were cloned and sequenced, their secondary and 3D structures were predicted, and their function was evaluated through RNAi-mediated gene knockdown and in vitro feeding on blood supplemented with ezetimibe, which inhibits cholesterol binding by NPC1 proteins. Subsequently, the protective efficacy of a recombinant form of NPC1 from O. moubata (rOmNPC1) was tested in a rabbit vaccine trial. While inhibiting cholesterol absorption with ezetimibe resulted in up to 77 % mortality in adult O. moubata, NPC1 gene knockdown and vaccination with rOmNPC1 decreased female reproductive performance in terms of the number and fertility of laid eggs. This study presents the initial molecular and functional insights into NPC1 proteins in soft ticks and supports the hypothesis that disrupting cholesterol metabolism diminishes tick viability and reproduction, rendering Niemann-Pick type C1 domain-containing proteins promising targets for drugs or vaccines.

BackgroundComprehensive antenatal care (ANC) must prioritize competent, evidence-based medical attention to ensure a positive experience and value for its users. Unfortunately, there is scarce evidence of implementing this holistic approach to ANC in low- and middle-income countries, leading to gaps in quality and accountability. This study assessed care competence, women's experiences during the first ANC visit, and the factors associated with these care attributes.Methods and findingsThe study analyzed cross-sectional baseline data from the maternal eCohort study conducted in Mexico from August to December 2023. The study adapted the Quality Evidence for Health System Transformation (QuEST) network questionnaires to the Mexican context and validated them through expert group and cognitive interviews with women. Pregnant women aged 18 to 49 who had their first ANC visit with a family physician were enrolled in 48 primary clinics of the Instituto Mexicano del Seguro Social across 8 states. Care competence and women's experiences with care were the primary outcomes. The statistical analysis comprised descriptive statistics, multivariable linear and Poisson regressions. A total of 1,390 pregnant women were included in the study. During their first ANC visit, women received only 67.7% of necessary clinical actions on average, and 52% rated their ANC experience as fair or poor. Women with previous pregnancies (adjusted regression coefficient [aCoef.] -3.55; (95% confidence intervals [95% CIs]): -4.88, -2.22, p < 0.001), at risk of depression (aCoef. -3.02; 95% CIs: -5.61, -0.43, p = 0.023), those with warning signs (aCoef. -2.84; 95% CIs: -4.65, -1.03, p = 0.003), common pregnancy discomforts (aCoef. -1.91; 95% CIs: -3.81, -0.02, p = 0.048), or those who had a visit duration of less than 20 minutes (ConclusionsWe found important gaps in adherence to ANC standards and that care competence during the first ANC visit is an important predictor of positive user experience. To inform quality improvement efforts, IMSS should institutionalize the routine monitoring of ANC competencies and ANC user experience. This will help identify poorly performing facilities and providers and address gaps in the provision of evidence-based and women-centered care.

It is expected that CO2 concentration will increase in the air, thereby stimulating the photosynthesis process and, hence, plant biomass production. In the case of legumes, increased biomass due to higher CO2 concentration can stimulate atmospheric nitrogen (N2) fixation in the nodules. However, N2 fixation is inhibited by external N supply. Thus, biomass production and N2 fixation were analysed in two legumes (Pisum sativum L. and Vicia faba L.) grown at two levels of CO2 and three N levels. P. sativum reduces fixation with high soil N (facultative), while V. faba maintains high fixation regardless of soil N levels (obligate). The N2 fixation and plant and nodule biomass of the two species were evaluated in a pot experiment under controlled conditions using growth chambers with artificial CO2 supply and N addition. The proportion of N derived from the air (%Ndfa) present in the plants’ biomass was calculated from the natural abundance of 15N and the N concentration of plant tissues using nonlegumes reference plants. Additionally, N content data are presented for both species growing at two levels of air CO2. The data may be useful for plant physiologists, especially those working on biological N2 fixation with non-model legumes at elevated CO2.

Se realizó el primer estudio sobre las aves de la Reserva Hídrica del Cerro Turega (RHCT), ubicada en la Cordillera Central, provincia de Coclé, Panamá. La Reserva forma parte de la cadena montañosa de la parte central del istmo de Panamá y forma parte del Corredor Biológico Mesoamericano. Se efectuaron muestreos entre febrero y mayo de 2021 con el fin de estudiar la riqueza y diversidad de aves en la RHCT. La toma de datos se realizó durante 32 días, y se utilizaron tres redes de niebla de 12 m de largo y 2.5 m de alto, abiertas desde las 7:00 am hasta las 11:00 am. En hora de la tarde, entre 1:00 a 5:00 pm se hicieron búsquedas generalizada y conteos por punto. La reserva posee una vegetación leñosa y de rastrojo, área intervenida con cultivos agrícolas y reducto boscoso. Se registraron 476 individuos de 100 especies, incluidos en 29 familias y 10 órdenes. Entre las especies con mayor abundancia estuvieron la chachalaca cabecigrís (Ortalis cinereiceps), eufonia piquigruesa (Euphonia laniirostris), mielero patirrojo (Cyanerpes cyaneus), tangara dorsirroja (Ramphocelus dimidiatus), golondrina alirrasposa sureña (Stelgidopteryx ruficollis), amazilia colirrufa (Amazilia tzacatl) y calzonario de buffon (Chalybura buffonii). Se registraron nueve migratorias, incluidas en cinco familias y dos órdenes, entre ellas el gavilán aludo (Buteo platypterus), elanio tijereta (Elanoides forficatus), tangara escarlata (Piranga olivácea), reinita pechicastaña (Setophaga castanea), reinita collareja (Cardellina canadensis), reinita trepadora (Mniotilta varia), vireo verdiamarillo (Vireo flavoviridis). Se identificaron 43 especies consideradas amenazadas, distribuidas en 12 familias y siete órdenes. En cuánto aves amenazadas observadas registramos loro cabeciazul (Pionus menstruus), tucancillo collarejo (Pteroglossus torquatus), tucán pico iris (Ramphastos sulfuratus). Entre las principales presiones sobre la reserva están la deforestación y el uso de agroquímicos para los sembradíos. Este estudio pionero brinda información para futuras investigaciones que se realicen en la zona y áreas aledañas, pues ahora se conoce que la RHCT posee las condiciones de hábitat apropiadas para aves residentes y migratorias.

A new radial memetic algorithm is proposed to resolve the no-wait job-shop scheduling problem. Basically, each sequencing solution is factorized as a distance-based ranking model, i.e., each solution is decomposed in n − 1 terms, where n is the number of jobs to be sequenced. After that, a cumulative radial distribution of hydrogen is considered to produce new factorizations using the offspring information (genes). Such radial distribution is applied in the local optimization procedure of the memetic algorithm. A benchmarking dataset is used to show the performance of this new experimental technique, as well as other current procedures. Statistical tests were implemented to confirm the performance of the proposed scheme.

This work utilizes a Gabor Holographic Optical Scheme integrated with a microscope objective and a thin convex plane lens. This bi-telecentric lens system corrects spherical aberration from the objective, maintains consistent magnification across various reconstruction distances, and ensures a plane incidence on CMOS. Depending on the focal lengths of the objective and lens, the final image can be enlarged or reduced compared to the classic Gabor system, resulting in high-quality reconstructed phase images without spherical aberration. This setup was employed to capture phase distribution and intensity images of planktonic objects, such as copepods, achieving superior image quality.

Se propone la conformación de un índice de riesgo por acaparamiento del agua (IRAA) capaz de diferenciar territorialmente a los acaparadores, tomando en consideración el uso que éstos le dan al agua, los volúmenes que acumulan, así como el estatus del recurso en cada cuenca y acuífero. El patrón de acaparamiento se establece al identificar a concesionarios y usos cuando los volúmenes otorgados concentran al menos 80 % de las aguas superficiales y/o subterráneas del municipio. El IRAA integra el grado de presión sobre el recurso hídrico para determinar el riesgo y permite vincular la gestión hídrica y la gestión de los usos de suelo, puesto que las actividades acaparadoras de agua quedan identificadas en cada municipio. El índice se aplicó en el estado de Puebla, donde de 174 municipios que cumplieron con los requerimientos metodológicos, 45.4 % resultó con riesgo muy alto, 41.4 % con riesgo alto, 10.9 % con riesgo medio y 2.3 % con riesgo bajo. Ninguno entró en la categoría de riesgo muy bajo, mostrando una tendencia marcada de riesgo hídrico por acaparamiento en el estado, que se corrobora con la presencia de acaparadores intermunicipales, también identificados en este estudio. A través del IRAA es posible determinar zonas de prioridad en la transformación de la gestión del agua que trasciende los organismos de cuenca e incorpora los territorios municipales. Propone a su vez argumentos para la justicia ambiental. Los métodos y técnicas empleadas se ubican en el ámbito de la ciencia de datos.

Cereals have been a foundational component of human diets across different continents, with rice dominating in Asia, sorghum in Africa, wheat in Europe, and maize in America. Mexico, more accurately Mesoamerica, is recognized as the origin of maize (including pigmented maize), with its first ancestor traced back to Tehuacán, Puebla, Mexico. Pigmented maize owes its vibrant colors due to its anthocyanin (i.e., cyanidin-3-glucoside) contents, which contribute to the red, purple, or blue coloration and offer notable health benefits. The antioxidant properties of maize are crucial, given the role of oxidative stress in various diseases, and present a valuable resource for functional foods and nutraceuticals. Emerging studies underscore the prebiotic potential of anthocyanins, showing their ability to modulate gut microbiota positively. This review aims to explore the potential of pigmented maize in traditional Mexican beverage (such as pozol and tejuino) production, emphasizing the bioactive compounds (mainly anthocyanins) present and their health benefits while also considering new opportunities in the functional food industry.

In the current digital landscape, artificial intelligence-driven automation has revolutionized efficiency in various areas, enabling significant time and resource savings. However, the reliability and efficiency of software systems remain crucial challenges. To address this issue, a generation of self-adaptive software has emerged with the ability to rectify errors and autonomously optimize performance. This study focuses on the development of self-adaptive software designed for pre-programmed tasks on the Internet. The software stands out for its self-adaptation, automation, fault tolerance, efficiency, and robustness. Various technologies such as Python, MySQL, Firebase, and others were employed to enhance the adaptability of the software. The results demonstrate the effectiveness of the software, with a continuously growing self-adaptation rate and improvements in response times. Probability models were applied to analyze the software’s effectiveness in fault situations. The implementation of virtual cables and multiprocessing significantly improved performance, achieving higher execution speed and scalability. In summary, this study presents self-adaptive software that rectifies errors, optimizes performance, and maintains functionality in the presence of faults, contributing to efficiency in Internet task automation.

Oxidative stress and apoptosis cell death are critical secondary damage mechanisms that lead to losing neighboring healthy tissue after cerebral ischemia. This study aims to characterize the type of interaction between dapsone (DDS) and cannabidiol (CBD) and its cytoprotective effect in an in vitro model of oxygen and glucose deprivation for 6 h followed by 24 h of reoxygenation (OGD/R), using the SH-SY5Y cell line. For the combined concentrations, an isobolographic study was designed to determine the optimal concentration–response combinations. Cell viability was evaluated by measuring the lactate dehydrogenase (LDH) release and 3-[4, 5-dimethyl-2-thiazolyl]-2, 5-diphenyl-2H-tetrazolium bromide (MTT) assays. Also, the reactive oxygen species (ROS) and reduced glutathione (GSH) levels were analyzed as oxidative stress markers. Finally, caspase-3 activity was evaluated as a marker cell death by apoptosis. The results showed a decrease in cell viability, an increase in oxidant stress, and the activity of caspase-3 by the effect of OGD/R. Meanwhile, both DDS and CBD demonstrated antioxidant, antiapoptotic, and cytoprotective effects in a concentration–response manner. The isobolographic study indicated that the concentration of 2.5 µM of DDS plus 0.05 µM of CBD presented a synergistic effect so that in treatment, cell death due to OGD/R decreased. The findings indicate that DDS–CBD combined treatment may be a helpful therapy in cerebral ischemia with reperfusion.

In medium- and low-voltage three-phase distribution networks, the load imbalance among the phases may compromise the network voltage symmetry. Inverter-interfaced distributed energy resources (DERs) can contribute to compensating for such imbalances by sharing the required negative sequence current while providing active power synchronized with the positive sequence voltage. However, positive and negative sequences are conventionally defined in a steady state and are not directly observed from the instantaneous voltage and current measurements at the DER unit’s point of connection. In this article, an estimation algorithm for sequence separation based on the Kalman filter is proposed. Furthermore, the proposed filter uses a complex vector representation of the asymmetric three-phase signals in synchronous coordinates to allow for the implementation of the Kalman filter in its stationary form, resulting in a simple dynamic filter able to estimate positive and negative sequences even during transient operation. The proposed stationary complex Kalman filter performs better than state-of-the-art techniques like DSOGI and very similarly to other Kalman filter implementations found in the literature but at a fraction of its computational cost (23.5%).

Introducción: El tema principal del artículo es las luchas de los trabajadores azucareros en Camagüey y el objeto de estudio es el incremento de las luchas de los trabajadores frente a las compañías norteamericanas y los latifundistas nativos. Métodos: Se emplearon como métodos: el análisis documental y entrevistas a dirigentes obreros que estuvieron involucrados en estas luchas entre 1952 a 1955, culminando con la huelga azucarera de 1955. Resultados: Muchos obreros fueron detenidos por distintas causas durante estos años, además fueron quemadas cientos de arrobas de caña como reacción de los trabajadores por las pésimas condiciones de vida que padecían en las colonias y los centrales azucareros. Conclusiones: Ante la movilización general de los trabajadores azucareros en las colonias y los centrales azucareros, quedó demostrado la fuerza y pujanza de los mismos frente a los exploradores.

ObjectiveThe Mexican government has pursued multiple initiatives to improve healthcare coverage and financial protection. Yet, out-of-pocket health spending and use of private sector providers in Mexico remains high. In this paper, we sought to describe the characteristics of public and private healthcare users, describe recent visit quality across provider types, and to assess whether perceiving the public healthcare sector as poor quality is associated with private health sector use.Methods and findingsWe analyzed the cross-sectional People's Voice Survey conducted from December 2022 to January 2023. We used Chi-square tests to compare contextual, individual, and need-for-care factors and ratings of most recent visits between users of public (social security and other public providers) and private sector providers (stand-alone private providers and providers adjacent to pharmacies). We used a multivariable Poisson regression model to assess associations between low ratings of public healthcare sources and the use of private care. Among the 811 respondents with a healthcare visit in the past year, 31.2% used private sources. Private healthcare users were more educated and had higher incomes than public healthcare users. Quality of most recent visit was rated more highly in private providers (70.2% rating the visit as excellent or very good for stand-alone private providers and 54.3% for pharmacy-adjacent doctors) compared to social security (41.6%) and other public providers (46.6%). Those who perceived public health institutions as low quality had a higher probability of seeking private healthcare.ConclusionUsers rated public care visits poorly relative to private care; at the population level, perceptions of poor quality care may drive private care use and hence out-of-pocket costs. Improving public healthcare quality is necessary to ensure universal health coverage.

Abstract The ECG diagnosis of LVH is predominantly based on the QRS voltage criteria. The classical paradigm postulates that the increased left ventricular mass generates a stronger electrical field, increasing the leftward and posterior QRS forces, reflected in the augmented QRS amplitude. However, the low sensitivity of voltage criteria has been repeatedly documented. We discuss possible reasons for this shortcoming and proposal of a new paradigm. The theoretical background for voltage measured at the body surface is defined by the solid angle theorem, which relates the measured voltage to spatial and non‐spatial determinants. The spatial determinants are represented by the extent of the activation front and the distance of the recording electrodes. The non‐spatial determinants comprise electrical characteristics of the myocardium, which are comparatively neglected in the interpretation of the QRS patterns. Various clinical conditions are associated with LVH. These conditions produce considerable diversity of electrical properties alterations thereby modifying the resultant QRS patterns. The spectrum of QRS patterns observed in LVH patients is quite broad, including also left axis deviation, left anterior fascicular block, incomplete and complete left bundle branch blocks, Q waves, and fragmented QRS. Importantly, the QRS complex can be within normal limits. The new paradigm stresses the electrophysiological background in interpreting QRS changes, i.e., the effect of the non‐spatial determinants. This postulates that the role of ECG is not to estimate LV size in LVH, but to understand and decode the underlying electrical processes, which are crucial in relation to cardiovascular risk assessment.

Intercropping legumes with cereals can lead to increased overall yield and optimize the utilization of resources such as water and nutrients, thus enhancing agricultural efficiency. Legumes possess the unique ability to acquire nitrogen (N) through both N2 fixation and from the available N in the soil. However, soil N can diminish the N2 fixation capacity of legumes. It is postulated that in intercropping, legumes uptake N mainly through N2 fixation, leaving more soil N available for cereals. The latter, in turn, has larger root systems, allowing it to explore greater soil volume and absorb more N, mitigating its adverse effects on N2 fixation in legumes. The goal of this study was to evaluate how the supply of N affects the intercropping of faba beans (Vicia faba L.) and peas (Pisum sativum L.) with wheat under varying plant densities and N levels. We measured photosynthetic traits, biomass production, the proportion of N derived from air (%Ndfa) in the shoot of the legumes, the N transferred to the wheat, and the land equivalent ratio (LER). The results revealed a positive correlation between soil N levels and the CO2 assimilation rate (An), chlorophyll content, and N balance index (NBI) in wheat. However, no significant effect was observed in legumes as soil N levels increased. Transpiration (E) increased in wheat intercropped with legumes, while stomatal conductance (gs) increased with N addition in all crops. Water use efficiency (WUE) decreased in faba beans intercropped with wheat as N increased, but it showed no significant change in wheat or peas. The shoot dry matter of wheat increased with the addition of N; however, the two legume species showed no significant changes. N addition reduced the %Ndfa of both legume species, especially in monoculture, with peas being more sensitive than faba beans. The intercropping of wheat alleviated N2 fixation inhibition, especially at high wheat density and increased N transfer to wheat, particularly with peas. The LER was higher in the intercropping treatments, especially under limited N conditions. It is concluded that in the intercropping of wheat with legumes, the N2 fixation inhibition caused by soil N is effectively reduced, as well as there being a significant N transfer from the legume to the wheat, with both process contributing to increase LER.

Common bean (Phaseolus vulgaris L.) is the primary grain legume cultivated worldwide for direct human consumption due to the high nutritional value of its seeds and pods. The high protein content of common beans highlights it as the most promising source of plant-based protein for the food industry. Additionally, landraces of common bean have great variability in nutritional traits, which is necessary to increase the nutritional quality of elite varieties. Therefore, the main objective of this study was to nutritionally characterize 23 Chilean landraces and 5 commercial varieties of common bean to identify genotypes with high nutritional value that are promising for the food industry and for genetic improvement programs. The landrace Phv23 (‘Palo’) was the most outstanding with high concentrations of minerals such as P (7.53 g/kg), K (19.8 g/kg), Mg (2.43 g/kg), Zn (52.67 mg/kg), and Cu (13.67 mg/kg); essential amino acids (364.8 mg/g protein); and total proteins (30.35 g/100 g seed). Additionally, the landraces Phv9 (‘Cimarrón’), Phv17 (‘Juanita’), Phv3 (‘Araucano’), Phv8 (‘Cabrita/Señorita’), and Phv4 (‘Arroz’) had a high protein content. The landrace Phv24 (‘Peumo’) stood out for its phenolic compounds (TPC = 218.1 mg GA/100 g seed) and antioxidant activity (ORAC = 22,167.9 μmol eq trolox/100 g extract), but it has moderate to low mineral and protein concentrations. In general, the concentration of nutritional compounds in some Chilean landraces was significantly different from the commercial varieties, highlighting their high nutritional value and their potential use for the food industry and for genetic improvement purposes.

The identification of new protective antigens for the development of tick vaccines may be approached by selecting antigen candidates that have key biological functions. Bioactive proteins playing key functions for tick feeding and pathogen transmission are secreted into the host via tick saliva. Adult argasid ticks must resynthesise and replace these proteins after each feeding to be able to repeat new trophogonic cycles. Therefore, these proteins are considered interesting antigen targets for tick vaccine development. In this study, the salivary gland transcriptome and saliva proteome of Ornithodoros erraticus females were inspected to select and test new vaccine candidate antigens. For this, we focused on transcripts overexpressed after feeding that encoded secretory proteins predicted to be immunogenic and annotated with functions related to blood ingestion and modulation of the host defensive response. Completeness of the transcript sequence, as well as a high expression level and a high fold-change after feeding were also scored resulting in the selection of four candidates, an acid tail salivary protein (OeATSP), a multiple coagulation factor deficiency protein 2 homolog (OeMCFD2), a Cu/Zn-superoxide dismutase (OeSOD) and a sulfotransferase (OeSULT), which were later produced as recombinant proteins. Vaccination of rabbits with each individual recombinant antigen induced strong humoral responses that reduced blood feeding and female reproduction, providing, respectively, 46.8%, 45.7%, 54.3% and 31.9% protection against O. erraticus infestations and 0.7%, 3.9%, 3.1% and 8.7% cross-protection against infestations by the African tick, Ornithodoros moubata. The joint protective efficacy of these antigens was tested in a second vaccine trial reaching 58.3% protection against O. erraticus and 18.6% cross-protection against O. moubata. These results (i) provide four new protective salivary antigens from argasid ticks that might be included in multi-antigenic vaccines designed for the control of multiple tick species; (ii) reveal four functional protein families never tested before as a source of protective antigens in ticks; and (iii) show that multi-antigenic vaccines increase vaccine efficacy compared with individual antigens. Finally, our data add value to the salivary glands as a protective antigen source in argasids for the control of tick infestations.

Ornithodoros erraticus and Ornithodoros moubata ticks are the main vectors of the agents of human relapsing fever (TBRF) and African swine fever (ASF) in the Mediterranean Basin and Africa, respectively. Tick ​​saliva is crucial for complete tick feeding and pathogen transmission, as it contains numerous molecules such as proteins, lipids, and non-coding RNAs (ncRNA) including microRNAs (miRNA). MiRNAs are small ncRNAs capable of regulating the expression of their target messenger RNA (mRNA) leading to degradation or inhibition of its translation into protein. Research on miRNAs from ixodid ticks has revealed that miRNAs are involved in the regulation of different physiological processes of ticks, as well as in the modulation of host gene expression, immune response to tick bite and pathogen transmission. Regarding argasid ticks, there is not information about their miRNAs or their potential involvement in tick physiology and/or in the regulation of the tick-host-pathogen interactions. The aim of this work was to profile the miRNAs expressed in the saliva of O. erraticus and O. moubata, and the in silico prediction and functional analysis of their target genes in the swine host. As a whole, up to 72 conserved miRNAs families were identified in both species: 35 of them were shared and 23 and 14 families were unique to O. erraticus and O. moubata, respectively. The most abundant miRNAs families were mir-1, mir-10 and let-7 in O. erraticus and let-7, mir-252, mir-10 in O. moubata. Four miRNAs sequences of each species were validated by RT-qPCR confirming their presence in the saliva. Target gene prediction in the host (Sus scrofa) and functional analysis showed that the selected miRNAs are mainly involved in processes related to signal transduction, regulation of mRNA transcription and gene expression, synapse regulation, immune response, angiogenesis and vascular development. These results suggest that miRNAs could play an important role at the tick-host interface, providing new insights into this complex relationship that may contribute to a more precise selection of tick molecules for the development of therapeutic and immune strategies to control tick infestations and tick-borne pathogens.

Los vehículos no holonómicos, es decir, aquellos vehículos que tienen restricciones de movimiento o no pueden seguir cualquier trayectoria deseada, son empleados en una amplia gama de actividades, tanto en la vida cotidiana como en ambientes industriales. En este trabajo se presenta una estrategia de navegación para vehículos tipo uniciclo, basada en campos potenciales de velocidad. La validación de la estrategia de navegación se realizó empleando simulación numérica y experimentos en la plataforma de prueba. Los resultados obtenidos muestran que el método estudiado cumple con la tarea asignada.

Summary: An excessive production of lactate by cancer cells fosters tumor growth and metastasis. Therefore, targeting lactate metabolism and transport offers a new therapeutic strategy against cancer, based on dependency of some cancer cells for lactate as energy fuel or as oncogenic signal. Herein we present a family of anionophores based on the structure of click-tambjamines that have proved to be extremely active lactate carriers across phospholipid membranes. Compound 1, the most potent lactate transmembrane carrier, was studied in HeLa cells. The use of a monocarboxylate transporters (MCTs) inhibitor proved that 1 is an active lactate transporter in living cells, confirming the results obtained in phospholipid vesicles. Moreover, an additive effect of compound 1 with cisplatin was observed in HeLa cells. Identification of active lactate anionophores working in living cells opens up ways to exploit this class of compounds as molecular tools and drugs addressing dysregulated lactate metabolism.

Background and aims: Body physique rating (BPR) is an index in which fat mass and muscle mass are used to indicate nine different body types. To our knowledge, there are no studies testing if there is a correlation between BPR and the risk of developing Metabolic Syndrome (MetS). Our objective was to assess if the BPR classification is an acceptable tool for assessing MetS risk in a population from Central Mexico. Methods: Subjects attending either IMSS UMF-2 or CSU-1 were asked to participate in this cross-sectional study. The participant's BPR was determined using the TANITA bio-analyzer (T-BPR) and an alternative BPR system (A-BPR), which was based on cutoffs for muscle and fat mass. MetS severity was determined with the ESF-I questionnaire. Using logistic regression, the odds ratio (OR) and 95% confidence interval (95%CI) were determined. Results: MetS severity was correlated with body fat percent (rho = 0.603, p