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2. Calorimetric Non-Destructive Assay of Large Volume and Heterogeneous Radioactive Waste Drums

Author

Kubinski W. R., Carasco C., Kikola D., Mathonat C., Ricard D., Tefelski D., and Tietze-Jaensch H.

Subjects
Physics, QC1-999
Abstract

The EU-CHANCE project aims at the issue of the characterization of conditioned radioactive waste (CRW) and one objective of CHANCE is to focus on: Calorimetry as a comprising non-destructive technique to reduce uncertainties on the inventory of radwaste containing shielded and hidden material difficult to be measured by other means. A MCNP6-based numerical study comprising the particle flux out of a 200L mock-up drum in a Large Volume Calorimeter (LVC) currently manufactured by KEP Nuclear (France) will be presented and discussed. For the analyses, the particle flux and energy deposition in each layer of the calorimeter were determined. The results yield that a significant fraction of the radiation would leave the system and not contribute to the measurable heat deposition. The expected energy deposition is obtained and cumulated for each layer over the whole energy range revealing the fraction of particles actually escaping the LVC calorimeter. While this escape fraction needs and can be determined, the LVC is a very suitable apparatus for the anticipated experiments on large and heterogeneous waste drums that possibly contain deeply buried beta-emitters (e.g. Sr/Y-90) or shielded alpha-sources hidden inside the drum with a significant level of gamma and neutron radiation background radiation. The high-energy part of this gamma and neutron flux may even reach the reference chamber of the calorimeter and deposit some energy there, compromising the calibration and may cause a double-bias.

Published
2020
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19. Subacute monomelic radiculoplexus neuropathy following Comirnaty© (Pfizer-BioNTech COVID-19) vaccination: A case report

Author

Coly, M., primary, Balcerac, A., additional, Brasseur, N., additional, Sallansonnet-Froment, M., additional, Tafani, C., additional, Taifas, I., additional, Bréchemier, M.L., additional, Drouard, E., additional, Foissaud, V., additional, Vest, P., additional, Vandendries, C., additional, Bompaire, F., additional, Bihan, K., additional, and Ricard, D., additional

Published
2023
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20. Advances in treatments of patients with classical and emergent neurological toxicities of anticancer agents

Author

Bompaire, F., primary, Birzu, C., additional, Bihan, K., additional, Desestret, V., additional, Fargeot, G., additional, Farina, A., additional, Joubert, B., additional, Leclercq, D., additional, Nichelli, L., additional, Picca, A., additional, Tafani, C., additional, Weiss, N., additional, Psimaras, D., additional, and Ricard, D., additional

Published
2023
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23. Simulating the optical signal radiated by lightning flashes for both imagery and photometry applications

Author

Rimboud, A., Defer, E., Cornet, C., Farges, T., Barthe, C., Labonnote, L., Thieuleux, F., Dubuisson, P., and Ricard, D.

Abstract

Optical observations carried out from low orbit satellites for twenty years have resulted in the first global map of lightning activity. Nowadays the current generation of geostationary meteorological satellites is equipped with lightning imagers like the European MTG (Meteosat Third Generation) LI (Lightning Imager). While on board the International Space Station, LIS (Lightning Imaging Sensor) and ASIM (Atmosphere-Space Interactions Monitor) instruments record optical lightning signal at different wavelengths, from near-UV to near-IR through imagery and photometry.Understanding the radiative transfer of light produced by the lightning discharges in the clouds is fundamental to interpret the detected optical signal. In this work, the forward three dimensional radiative code 3DMCPOL (Cornet et al., 2010) is adapted to simulate realistic lightning waveforms and images. The 3DMCPOL code usually models the light scattering by the cloud hydrometeors by using a Monte-Carlo method in a three-dimensional atmosphere, originally for solar or thermal sources. In the present study, a realistic 4-dimension (time and space) lightning source is considered and its detection at 337 and 777 nm by ground-based or space-borne photometers and cameras is simulated.The methodology will be first presented. Then realistic simulations of optical signal derived from the microphysical and electrical outputs of the French cloud resolving model Meso-NH will be discussed considering both imaging and photometry. Finally the main results will be related i) to the MTG-LI and ASIM observations, and ii) to the French-Israeli C³IEL (Cluster for Cloud evolution Climate and Lightning) mission under development., The 28th IUGG General Assembly (IUGG2023) (Berlin 2023)

Published
2023
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25. Evaluation of the psychometric properties of the EORTC chemotherapy-induced peripheral neuropathy questionnaire (QLQ-CIPN20)

Author

Kieffer, Jacobien M., Postma, Tjeerd J., van de Poll-Franse, Lonneke, Mols, Floortje, Heimans, Jan J., Cavaletti, Guido, Aaronson, Neil K., Cavaletti, G., Cornblath, D. R., Merkies, I. S. J., Postma, T. J., Valsecchi, M. G., Galimberti, S., Rossi, E., Cavaletti, G., Frigeni, B., Lanzani, F., Mattavelli, L., Piatti, M. L., Alberti, P., Binda, D., Bidoli, P., Cazzaniga, M., Cortinovis, D., Bruna, J., Velasco, R., Argyriou, A. A., Kalofonos, H. P., Psimaras, D., Ricard, D., Pace, A., Galiè, E., Briani, C., Lucchetta, M., Campagnolo, M., Torre, C. Dalla, Faber, C. G., Merkies, I. S. J., Vanhoutte, E. K., Bakkers, M., Brouwer, B., Boogerd, M., Lalisang, R. I., Boogerd, W., Brandsma, D., Koeppen, S., Hense, J., Grant, R., Storey, D., Kerrigan, S., Schenone, A., Reni, L., Piras, B., Fabbri, S., Pessino, A., Padua, L., Granata, G., Leandri, M., Ghignotti, I., Plasmati, R., Pastorelli, F., Postma, T. J., Heimans, J. J., Eurelings, M., Meijer, R. J., Grisold, W., Pozza, E. Lindeck, Mazzeo, A., Toscano, A., Russo, M., Tomasello, C., Altavilla, G., Prado, M. Penas, Gonzalez, C. Dominguez, Dorsey, S. G., and In Collaboration with the CI-PeriNomS Group

Published
2017
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27. Pseudo-tumour lesion of the brainstem: A case and discussion

Author

Maillot, J., primary, Brunet de Courssou, J.-B., additional, Brechemier, M.-L., additional, Tafani, C., additional, Sallansonnet-Froment, M., additional, Taifas, I., additional, Cournac, J.-M., additional, Drouard, E., additional, Bompaire, F., additional, Faivre, A., additional, and Ricard, D., additional

Published
2022
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29. Physician-assessed and patient-reported outcome measures in chemotherapy-induced sensory peripheral neurotoxicity: two sides of the same coin

Author

Cavaletti, G., Cornblath, D.R., Merkies, I.S.J., Postma, T.J., Valsecchi, M.G, Galimberti, S., Rossi, E., Frigeni, B., Lanzani, F., Mattavelli, L., Piatti, M.L., Alberti, P., Binda, D., Bidoli, P., Cazzaniga, M., Cortinovis, D., Bruna, J., Velasco, R., Argyriou, A.A., Kalofonos, H.P., Psimaras, D., Ricard, D., Pace, A., Galiè, E., Briani, C., Lucchetta, M., Campagnolo, M., Dalla Torre, C., Faber, C.G., Vanhoutte, E.K., Bakkers, M., Brouwer, B., Lalisang, R.I., Boogerd, W., Brandsma, D., Koeppen, S., Hense, J., Grant, R., Storey, D., Kerrigan, S., Schenone, A., Reni, L., Piras, B., Fabbri, S., Padua, L., Granata, G., Leandri, M., Ghignotti, I., Plasmati, R., Pastorelli, F., Heimans, J.J., Eurelings, M., Meijer, R.J., Grisold, W., Lindeck Pozza, E., Mazzeo, A., Toscano, A., Tomasello, C., Altavilla, G., Penas Prado, M., Dominguez Gonzalez, C., Dorsey, S.G., Brell, J.M., and Valsecchi, M.G.

Published
2014
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30. Biopsychosocial determinants of visuospatial memory performance according to different spaces

Author

Bherer, L., Gallou-Guyot, M., Mandigout, S., Lacroix, J., Ricard, D., Buffat, S., Archambeau, D., Guéguin, G., Perrochon, A., Handicap, Activité, Vieillissement, Autonomie, Environnement (HAVAE), Institut Génomique, Environnement, Immunité, Santé, Thérapeutique (GEIST), and Université de Limoges (UNILIM)-Université de Limoges (UNILIM)

Subjects
Adult, Male, 0301 basic medicine, Biopsychosocial model, Visuospatial memory, Dual-task training, Walking, Spatial memory, Mental rotation, Physical activity level, Pittsburgh Sleep Quality Index, Young Adult, 03 medical and health sciences, Cognition, 0302 clinical medicine, Humans, Gait, Fatigue, Exergame, General Neuroscience, Epworth Sleepiness Scale, Healthy older adults, factors, Physical functions, General Medicine, Navigation, Cognitive functions, 030104 developmental biology, Mood, Female, Psychology, Psychosocial, [SDV.MHEP]Life Sciences [q-bio]/Human health and pathology, 030217 neurology & neurosurgery, Cognitive psychology
Abstract

International audience; Visuospatial memory (VSM) performance depends on intrinsic (biopsychosocial parameters) and extrinsic (space) factors. We aimed at characterizing the determinants of VSM performance according to space. Young healthy adults, 20 males and 41 females (23 ± 3 years old), were assessed for VSM performance through a pathway learning task, in reaching (eCorsi Block Tapping task) and walking space (Virtual Walking Corsi Task). We evaluated psychosocial factors through seven questionnaires - Epworth Sleepiness Scale, Pittsburgh Sleep Quality Index, Fatigue Severity Scale, Profile of the Mood States, 2nd edition, short version, Coping Inventory for Stressful Situations, Measurement of Ambiguity Tolerance, Motives for Physical Activities Measure-Revised, mental rotation capabilities and locomotor characteristics (physical activity level through embedded trackers and the International Physical Activity Questionnaire, and gait parameters). The most explanatory biopsychosocial determinants of VSM performance were i) mental rotation capabilities and fatigue indicator in reaching space, and ii) mental rotation capabilities and physical activity level (tracked active energy expenditure only) in walking space. These results suggest that specific parameters should be preferred for the evaluation and strengthening of VSM capabilities in both reaching or walking spaces.

Published
2021
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36. Patients' and physicians' interpretation of chemotherapy-induced peripheral neurotoxicity

Author

Cavaletti, G., Cornblath, D. R., Merkies, I. S. J., Postma, T. J., Rossi, E., Alberti, Paola, Bruna, J., Argyriou, A. A., Briani, C., Velasco, Riccardo, Kalofonos, H. P., Psimaras, D., Ricard, D., Pace, A., Faber, C. G., Lalisang, R. I., Brandsma, D., Koeppen, S., Kerrigan, S., Schenone, A., Grisold, W., Mazzeo, A., Padua, L., Dorsey, S. G., Penas-Prado, M., Valsecchi, M. G., Frigeni, B., Lanzani, F., Mattavelli, L., Piatti, M. L., Binda, D., Bidoli, P., Cazzaniga, M., Cortinovis, D., Galie, E., Campagnolo, M., Salvalaggio, A., Ruiz, M., Vanhoutte, E. K., Boogerd, W., Hense, J., Grant, R., Storey, D., Reni, L., Demichelis, C., Pessino, A., Granata, G., Leandri, Martina, Ghigliotti, I., Plasmati, R., Pastorelli, Federica, Heimans, J. J., Eurelings, M., Meijer, R. J., Pozza, E. L., Toscano, A., Gentile, L., Santarpia, M., Gonzalez, C. D., Klinische Neurowetenschappen, MUMC+: MA Med Staf Spec Neurologie (9), RS: MHeNs - R1 - Cognitive Neuropsychiatry and Clinical Neuroscience, Interne Geneeskunde, MUMC+: MA Medische Oncologie (9), RS: GROW - R3 - Innovative Cancer Diagnostics & Therapy, MUMC+: DA KG Polikliniek (9), Cavaletti, G, Cornblath, D, Merkies, I, Postma, T, Rossi, E, Alberti, P, Bruna, J, Argyriou, A, Briani, C, Velasco, R, Kalofonos, H, Psimaras, D, Ricard, D, Pace, A, Faber, C, Lalisang, R, Brandsma, D, Koeppen, S, Kerrigan, S, Schenone, A, Grisold, W, Mazzeo, A, Padua, L, Dorsey, S, Penas-Prado, M, Valsecchi, M, Bidoli, P, Cazzaniga, M, Neurology, and CCA - Cancer Treatment and quality of life

Subjects
Adult, medicine.medical_specialty, Activities of daily living, side effect, media_common.quotation_subject, medicine.medical_treatment, assessment, chemotherapy, neurotoxicity, patient reported outcome measures, side effects, Medizin, NEUROPATHY CIPN, Neurological examination, Severity of Illness Index, 03 medical and health sciences, Vibration perception, 0302 clinical medicine, Perception, Internal medicine, Activities of Daily Living, medicine, Humans, VALIDITY, media_common, Oncologists, Neuroscience (all), Neurology (clinical), Chemotherapy, medicine.diagnostic_test, business.industry, General Neuroscience, Neurotoxicity, Outcome measures, Peripheral Nervous System Diseases, assessment, chemotherapy, neurotoxicity, patient reported outcome measures, side effects, Adult, Humans, Neurotoxicity Syndromes, Peripheral Nervous System Diseases, Activities of Daily Living, Oncologists, Patient Reported Outcome Measures, Severity of Illness Index, OUTCOME MEASURES, medicine.disease, Peripheral, patient reported outcome measure, 030220 oncology & carcinogenesis, Neurotoxicity Syndromes, business, 030217 neurology & neurosurgery
Abstract

To test if and how chemotherapy-induced peripheral neurotoxicity (CIPN) is perceived differently by patients and physicians, making assessment and interpretation challenging. We performed a secondary analysis of the CI-PeriNomS study which included 281 patients with stable CIPN. We tested: (a) the association between patients' perception of activity limitation in performing eight common tasks and neurological impairment and (b) how the responses to questions related to these daily activities are interpreted by the treating oncologist. To achieve this, we compared patients' perception of their activity limitation with neurological assessment and the oncologists' blind interpretation. Distribution of the scores attributed by oncologists to each daily life maximum limitation ("impossible") generated three groups: Group 1 included limitations oncologists attributed mainly to motor impairment; Group 2 ones mainly attributed to sensory impairment and Group 3 ones with uncertain motor and sensory impairment. Only a subset of questions showed a significant trend between severity in subjective limitation, reported by patients, and neurological impairment. In Group 1, neurological examination confirmed motor impairment in only 51%-65% of patients; 76%-78% of them also had vibration perception impairment. In Group 2, sensory impairment ranged from 84% to 100%; some degree of motor impairment occurred in 43%-56% of them. In Group 3 strength reduction was observed in 49%-50% and sensory perception was altered in up to 82%. Interpretation provided by the panel of experienced oncologists was inconsistent with the neurological impairment. These observations highlight the need of a core set of outcome measures for future CIPN trials.

Published
2019
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41. Physician-assessed and patient-reported outcome measures in chemotherapy-induced sensory peripheral neurotoxicity: two sides of the same coin

Author

Alberti, P., Rossi, E., Cornblath, D. R., Merkies, I. S. J., Postma, T. J., Frigeni, B., Bruna, J., Velasco, R., Argyriou, A. A., Kalofonos, H. P., Psimaras, D., Ricard, D., Pace, A., Galiè, E., Briani, C., Dalla Torre, C., Faber, C. G., Lalisang, R. I., Boogerd, W., Brandsma, D., Koeppen, S., Hense, J., Storey, D., Kerrigan, S., Schenone, A., Fabbri, S., Valsecchi, M. G., Cavaletti, G., Cavaletti, G., Cornblath, D.R., Merkies, I.S.J., Postma, T.J., Valsecchi, M.G, Galimberti, S., Rossi, E., Cavaletti, G., Frigeni, B., Lanzani, F., Mattavelli, L., Piatti, ML., Alberti, P., Binda, D., Bidoli, P.., Cazzaniga, M., Cortinovis, D., Bruna, J., Velasco, R., Argyriou, AA., Kalofonos, HP., Psimaras, D., Ricard, D., Pace, A., Galiè, E., Briani, C., Lucchetta, M., Campagnolo, M., Dalla Torre, C., Merkies, ISJ., Faber, CG., Merkies, ISJ., Vanhoutte, EK., Bakkers, M., Brouwer, B., Lalisang, RI., Boogerd, W., Brandsma, D., Koeppen, S., Hense, J., Grant, R., Storey, D., Kerrigan, S., Schenone, A., Reni, L., Piras, B., Fabbri, S., Padua, L., Granata, G., Leandri, M., Ghignotti, I., Plasmati, R.., Pastorelli, F., Postma, TJ., Heimans, JJ., Eurelings, M., Meijer, RJ., Grisold, W., Lindeck Pozza, E., Mazzeo, A., Toscano, A., Tomasello, C., Altavilla, G., Penas Prado, M., Dominguez Gonzalez, C., Dorsey, SG., and Brell, JM.

Published
2014
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43. The chemotherapy-induced peripheral neuropathy outcome measures standardization study: from consensus to the first validity and reliability findings

Author

Cavaletti, G., Cornblath, D. R., Merkies, I. S. J., Postma, T. J., Rossi, E., Frigeni, B., Alberti, P., Bruna, J., Velasco, R., Argyriou, A. A., Kalofonos, H. P., Psimaras, D., Ricard, D., Pace, A., Galiè, E., Briani, C., Dalla Torre, C., Faber, C. G., Lalisang, R. I., Boogerd, W., Brandsma, D., Koeppen, S., Hense, J., Storey, D., Kerrigan, S., Schenone, A., Fabbri, S., Valsecchi, M. G., Mazzeo, A., Pace, A., Pessino, A., Schenone, A., Toscano, A., Argyriou, A.A., Brouwer, B., Frigeni, B., Piras, B., Briani, C., Dalla Torre, C., Dominguez Gonzalez, C., Faber, C. G., Tomasello, C., Binda, D., Brandsma, D., Cortinovis, D., Psimaras, D., Ricard, D., Storey, D., Cornblath, D.R., Galiè, E., Lindeck Pozza, E., Rossi, E., Vanhoutte, E.K., Lanzani, F., Pastorelli, F., Altavilla, G., Cavaletti, G., Granata, G., Kalofonos, H.P., Ghignotti, I., Merkies, I.S.J., Bruna, J., Hense, J., Heimans, J.J., Mattavelli, L., Padua, L., Reni, L., Bakkers, M., Boogerd, M., Campagnolo, M., Cazzaniga, M., Eurelings, M., Leandri, M., Lucchetta, M., Penas Prado, M., Russo, M., Valsecchi, M.G., Piatti, M.L., Alberti, P., Bidoli, P., Grant, R., Plasmati, R., Velasco, R., Lalisang, R.I., Meijer, R.J., Fabbri, S., Dorsey, S. G., Galimberti, S., Kerrigan, S., Koeppen, S., Postma, T.J., Boogerd, W., and Grisold, W.

Published
2013
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50. Onco-neural antibodies and tumour type determine survival and neurological symptoms in paraneoplastic neurological syndromes with Hu or CV2/CRMP5 antibodies

Author

Honnorat, J., Cartalat-Carel, S., Ricard, D., Camdessanche, J., Carpentier, A. F., Rogemond, V., Chapuis, F., Aguera, M., Decullier, E., Duchemin, A.M., Graus, F., and Antoine, J.C.

Subjects
Antibodies -- Usage, Antibodies -- Health aspects, Viral antibodies -- Usage, Viral antibodies -- Health aspects, Neurologic manifestations of general diseases -- Care and treatment, Neurologic manifestations of general diseases -- Patient outcomes, Tumors -- Research, Tumors -- Patient outcomes, Health, Psychology and mental health
Published
2009

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