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1. Correction: Distinct germline genetic susceptibility profiles identified for common non-Hodgkin lymphoma subtypes

Author: Berndt, Sonja I., Vijai, Joseph, Benavente, Yolanda, Camp, Nicola J., Nieters, Alexandra, Wang, Zhaoming, Smedby, Karin E., Kleinstern, Geffen, Hjalgrim, Henrik, Besson, Caroline, Skibola, Christine F., Morton, Lindsay M., Brooks-Wilson, Angela R., Teras, Lauren R., Breeze, Charles, Arias, Joshua, Adami, Hans-Olov, Albanes, Demetrius, Anderson, Kenneth C., Ansell, Stephen M., Bassig, Bryan, Becker, Nikolaus, Bhatti, Parveen, Birmann, Brenda M., Boffetta, Paolo, Bracci, Paige M., Brennan, Paul, Brown, Elizabeth E., Burdett, Laurie, Cannon-Albright, Lisa A., Chang, Ellen T., Chiu, Brian C. H., Chung, Charles C., Clavel, Jacqueline, Cocco, Pierluigi, Colditz, Graham, Conde, Lucia, Conti, David V., Cox, David G., Curtin, Karen, Casabonne, Delphine, De Vivo, Immaculata, Diepstra, Arjan, Diver, W. Ryan, Dogan, Ahmet, Edlund, Christopher K., Foretova, Lenka, Fraumeni, Jr, Joseph F., Gabbas, Attilio, Ghesquières, Hervé, Giles, Graham G., Glaser, Sally, Glenn, Martha, Glimelius, Bengt, Gu, Jian, Habermann, Thomas M., Haiman, Christopher A., Haioun, Corinne, Hofmann, Jonathan N., Holford, Theodore R., Holly, Elizabeth A., Hutchinson, Amy, Izhar, Aalin, Jackson, Rebecca D., Jarrett, Ruth F., Kaaks, Rudolph, Kane, Eleanor, Kolonel, Laurence N., Kong, Yinfei, Kraft, Peter, Kricker, Anne, Lake, Annette, Lan, Qing, Lawrence, Charles, Li, Dalin, Liebow, Mark, Link, Brian K., Magnani, Corrado, Maynadie, Marc, McKay, James, Melbye, Mads, Miligi, Lucia, Milne, Roger L., Molina, Thierry J., Monnereau, Alain, Montalvan, Rebecca, North, Kari E., Novak, Anne J., Onel, Kenan, Purdue, Mark P., Rand, Kristin A., Riboli, Elio, Riby, Jacques, Roman, Eve, Salles, Gilles, Sborov, Douglas W., Severson, Richard K., Shanafelt, Tait D., Smith, Martyn T., Smith, Alexandra, Song, Kevin W., Song, Lei, Southey, Melissa C., Spinelli, John J., Staines, Anthony, Stephens, Deborah, Sutherland, Heather J., Tkachuk, Kaitlyn, Thompson, Carrie A., Tilly, Hervé, Tinker, Lesley F., Travis, Ruth C., Turner, Jenny, Vachon, Celine M., Vajdic, Claire M., Van Den Berg, Anke, Van Den Berg, David J., Vermeulen, Roel C. H., Vineis, Paolo, Wang, Sophia S., Weiderpass, Elisabete, Weiner, George J., Weinstein, Stephanie, Doo, Nicole Wong, Ye, Yuanqing, Yeager, Meredith, Yu, Kai, Zeleniuch-Jacquotte, Anne, Zhang, Yawei, Zheng, Tongzhang, Ziv, Elad, Sampson, Joshua, Chatterjee, Nilanjan, Offit, Kenneth, Cozen, Wendy, Wu, Xifeng, Cerhan, James R., Chanock, Stephen J., Slager, Susan L., and Rothman, Nathaniel
Published: 2023
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2. Distinct germline genetic susceptibility profiles identified for common non-Hodgkin lymphoma subtypes

Author: Berndt, Sonja I., Vijai, Joseph, Benavente, Yolanda, Camp, Nicola J., Nieters, Alexandra, Wang, Zhaoming, Smedby, Karin E., Kleinstern, Geffen, Hjalgrim, Henrik, Besson, Caroline, Skibola, Christine F., Morton, Lindsay M., Brooks-Wilson, Angela R., Teras, Lauren R., Breeze, Charles, Arias, Joshua, Adami, Hans-Olov, Albanes, Demetrius, Anderson, Kenneth C., Ansell, Stephen M., Bassig, Bryan, Becker, Nikolaus, Bhatti, Parveen, Birmann, Brenda M., Boffetta, Paolo, Bracci, Paige M., Brennan, Paul, Brown, Elizabeth E., Burdett, Laurie, Cannon-Albright, Lisa A., Chang, Ellen T., Chiu, Brian C. H., Chung, Charles C., Clavel, Jacqueline, Cocco, Pierluigi, Colditz, Graham, Conde, Lucia, Conti, David V., Cox, David G., Curtin, Karen, Casabonne, Delphine, De Vivo, Immaculata, Diepstra, Arjan, Diver, W. Ryan, Dogan, Ahmet, Edlund, Christopher K., Foretova, Lenka, Fraumeni, Jr, Joseph F., Gabbas, Attilio, Ghesquières, Hervé, Giles, Graham G., Glaser, Sally, Glenn, Martha, Glimelius, Bengt, Gu, Jian, Habermann, Thomas M., Haiman, Christopher A., Haioun, Corinne, Hofmann, Jonathan N., Holford, Theodore R., Holly, Elizabeth A., Hutchinson, Amy, Izhar, Aalin, Jackson, Rebecca D., Jarrett, Ruth F., Kaaks, Rudolph, Kane, Eleanor, Kolonel, Laurence N., Kong, Yinfei, Kraft, Peter, Kricker, Anne, Lake, Annette, Lan, Qing, Lawrence, Charles, Li, Dalin, Liebow, Mark, Link, Brian K., Magnani, Corrado, Maynadie, Marc, McKay, James, Melbye, Mads, Miligi, Lucia, Milne, Roger L., Molina, Thierry J., Monnereau, Alain, Montalvan, Rebecca, North, Kari E., Novak, Anne J., Onel, Kenan, Purdue, Mark P., Rand, Kristin A., Riboli, Elio, Riby, Jacques, Roman, Eve, Salles, Gilles, Sborov, Douglas W., Severson, Richard K., Shanafelt, Tait D., Smith, Martyn T., Smith, Alexandra, Song, Kevin W., Song, Lei, Southey, Melissa C., Spinelli, John J., Staines, Anthony, Stephens, Deborah, Sutherland, Heather J., Tkachuk, Kaitlyn, Thompson, Carrie A., Tilly, Hervé, Tinker, Lesley F., Travis, Ruth C., Turner, Jenny, Vachon, Celine M., Vajdic, Claire M., Van Den Berg, Anke, Van Den Berg, David J., Vermeulen, Roel C. H., Vineis, Paolo, Wang, Sophia S., Weiderpass, Elisabete, Weiner, George J., Weinstein, Stephanie, Doo, Nicole Wong, Ye, Yuanqing, Yeager, Meredith, Yu, Kai, Zeleniuch-Jacquotte, Anne, Zhang, Yawei, Zheng, Tongzhang, Ziv, Elad, Sampson, Joshua, Chatterjee, Nilanjan, Offit, Kenneth, Cozen, Wendy, Wu, Xifeng, Cerhan, James R., Chanock, Stephen J., Slager, Susan L., and Rothman, Nathaniel
Published: 2022
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3. Genetically predicted longer telomere length is associated with increased risk of B-cell lymphoma subtypes

Author: Machiela, Mitchell J, Lan, Qing, Slager, Susan L, Vermeulen, Roel CH, Teras, Lauren R, Camp, Nicola J, Cerhan, James R, Spinelli, John J, Wang, Sophia S, Nieters, Alexandra, Vijai, Joseph, Yeager, Meredith, Wang, Zhaoming, Ghesquières, Hervé, McKay, James, Conde, Lucia, de Bakker, Paul IW, Cox, David G, Burdett, Laurie, Monnereau, Alain, Flowers, Christopher R, De Roos, Anneclaire J, Brooks-Wilson, Angela R, Giles, Graham G, Melbye, Mads, Gu, Jian, Jackson, Rebecca D, Kane, Eleanor, Purdue, Mark P, Vajdic, Claire M, Albanes, Demetrius, Kelly, Rachel S, Zucca, Mariagrazia, Bertrand, Kimberly A, Zeleniuch-Jacquotte, Anne, Lawrence, Charles, Hutchinson, Amy, Zhi, Degui, Habermann, Thomas M, Link, Brian K, Novak, Anne J, Dogan, Ahmet, Asmann, Yan W, Liebow, Mark, Thompson, Carrie A, Ansell, Stephen M, Witzig, Thomas E, Tilly, Hervé, Haioun, Corinne, Molina, Thierry J, Hjalgrim, Henrik, Glimelius, Bengt, Adami, Hans-Olov, Roos, Göran, Bracci, Paige M, Riby, Jacques, Smith, Martyn T, Holly, Elizabeth A, Cozen, Wendy, Hartge, Patricia, Morton, Lindsay M, Severson, Richard K, Tinker, Lesley F, North, Kari E, Becker, Nikolaus, Benavente, Yolanda, Boffetta, Paolo, Brennan, Paul, Foretova, Lenka, Maynadie, Marc, Staines, Anthony, Lightfoot, Tracy, Crouch, Simon, Smith, Alex, Roman, Eve, Diver, W Ryan, Offit, Kenneth, Zelenetz, Andrew, Klein, Robert J, Villano, Danylo J, Zheng, Tongzhang, Zhang, Yawei, Holford, Theodore R, Turner, Jenny, Southey, Melissa C, Clavel, Jacqueline, Virtamo, Jarmo, Weinstein, Stephanie, Riboli, Elio, Vineis, Paolo, Kaaks, Rudolph, Boeing, Heiner, Tjønneland, Anne, Angelucci, Emanuele, Di Lollo, Simonetta, Rais, Marco, De Vivo, Immaculata, Giovannucci, Edward, Kraft, Peter, and Huang, Jinyan
Subjects: Clinical Research, Rare Diseases, Genetics, Cancer, Hematology, Lymphoma, Adolescent, Adult, Age Factors, Aged, Aged, 80 and over, Female, Genetic Association Studies, Genetic Predisposition to Disease, Humans, Lymphoma, B-Cell, Male, Middle Aged, Prospective Studies, Telomere, Biological Sciences, Medical and Health Sciences, Genetics & Heredity
Abstract: Evidence from a small number of studies suggests that longer telomere length measured in peripheral leukocytes is associated with an increased risk of non-Hodgkin lymphoma (NHL). However, these studies may be biased by reverse causation, confounded by unmeasured environmental exposures and might miss time points for which prospective telomere measurement would best reveal a relationship between telomere length and NHL risk. We performed an analysis of genetically inferred telomere length and NHL risk in a study of 10 102 NHL cases of the four most common B-cell histologic types and 9562 controls using a genetic risk score (GRS) comprising nine telomere length-associated single-nucleotide polymorphisms. This approach uses existing genotype data and estimates telomere length by weighing the number of telomere length-associated variant alleles an individual carries with the published change in kb of telomere length. The analysis of the telomere length GRS resulted in an association between longer telomere length and increased NHL risk [four B-cell histologic types combined; odds ratio (OR) = 1.49, 95% CI 1.22-1.82,P-value = 8.5 × 10(-5)]. Subtype-specific analyses indicated that chronic lymphocytic leukemia or small lymphocytic lymphoma (CLL/SLL) was the principal NHL subtype contributing to this association (OR = 2.60, 95% CI 1.93-3.51,P-value = 4.0 × 10(-10)). Significant interactions were observed across strata of sex for CLL/SLL and marginal zone lymphoma subtypes as well as age for the follicular lymphoma subtype. Our results indicate that a genetic background that favors longer telomere length may increase NHL risk, particularly risk of CLL/SLL, and are consistent with earlier studies relating longer telomere length with increased NHL risk.
Published: 2016

4. The potential relevance of the endocannabinoid, 2-arachidonoylglycerol, in diffuse large B-cell lymphoma.

Author: Zhang, Jianqing, Medina-Cleghorn, Daniel, Bernal-Mizrachi, Leon, Bracci, Paige, Hubbard, Alan, Conde, Lucia, Riby, Jacques, Nomura, Daniel, and Skibola, Christine
Subjects: 2-AG, DLBCL, endocannabinoids, lymphoma, obesity
Abstract: Diffuse large B-cell lymphoma is an aggressive, genetically heterogenerous disease and the most common type of non-Hodgkin lymphoma among adults. To gain further insights into the etiology of DLBCL and to discover potential disease-related factors, we performed a serum lipid analysis on a subset of individuals from a population-based NHL case-control study. An untargeted mass-spectrometry-based metabolomics platform was used to analyze serum samples from 100 DLBCL patients and 100 healthy matched controls. Significantly elevated levels of the endocannabinoid, 2-arachidonoylglycerol (2-AG), were detected in the serum of DLBCL patients (121%, P < 0.05). In the male controls, elevated 2-AG levels were observed in those who were overweight (BMI ≥ 25 - < 30 kg/m2; 108%, P < 0.01) and obese (BMI ≥ 30 kg/m(2); 118%, P < 0.001) compared to those with a BMI < 25 kg/m(2). DLBCL cell lines treated with exogenous 2-AG across a range of concentrations, exhibited heterogenous responses: proliferation rates were markedly higher in 4 cell lines by 22%-68% (P < 0.001) and lower in 8 by 20%-75% (P < 0.001). The combined findings of elevated 2-AG levels in DLBCL patients and the proliferative effects of 2-AG on a subset of DLBCL cell lines suggests that 2-AG may play a potential role in the pathogenesis or progression of a subset of DLBCLs.
Published: 2016

5. A genome-wide association study of marginal zone lymphoma shows association to the HLA region.

Author: Vijai, Joseph, Wang, Zhaoming, Berndt, Sonja I, Skibola, Christine F, Slager, Susan L, de Sanjose, Silvia, Melbye, Mads, Glimelius, Bengt, Bracci, Paige M, Conde, Lucia, Birmann, Brenda M, Wang, Sophia S, Brooks-Wilson, Angela R, Lan, Qing, de Bakker, Paul IW, Vermeulen, Roel CH, Portlock, Carol, Ansell, Stephen M, Link, Brian K, Riby, Jacques, North, Kari E, Gu, Jian, Hjalgrim, Henrik, Cozen, Wendy, Becker, Nikolaus, Teras, Lauren R, Spinelli, John J, Turner, Jenny, Zhang, Yawei, Purdue, Mark P, Giles, Graham G, Kelly, Rachel S, Zeleniuch-Jacquotte, Anne, Ennas, Maria Grazia, Monnereau, Alain, Bertrand, Kimberly A, Albanes, Demetrius, Lightfoot, Tracy, Yeager, Meredith, Chung, Charles C, Burdett, Laurie, Hutchinson, Amy, Lawrence, Charles, Montalvan, Rebecca, Liang, Liming, Huang, Jinyan, Ma, Baoshan, Villano, Danylo J, Maria, Ann, Corines, Marina, Thomas, Tinu, Novak, Anne J, Dogan, Ahmet, Liebow, Mark, Thompson, Carrie A, Witzig, Thomas E, Habermann, Thomas M, Weiner, George J, Smith, Martyn T, Holly, Elizabeth A, Jackson, Rebecca D, Tinker, Lesley F, Ye, Yuanqing, Adami, Hans-Olov, Smedby, Karin E, De Roos, Anneclaire J, Hartge, Patricia, Morton, Lindsay M, Severson, Richard K, Benavente, Yolanda, Boffetta, Paolo, Brennan, Paul, Foretova, Lenka, Maynadie, Marc, McKay, James, Staines, Anthony, Diver, W Ryan, Vajdic, Claire M, Armstrong, Bruce K, Kricker, Anne, Zheng, Tongzhang, Holford, Theodore R, Severi, Gianluca, Vineis, Paolo, Ferri, Giovanni M, Ricco, Rosalia, Miligi, Lucia, Clavel, Jacqueline, Giovannucci, Edward, Kraft, Peter, Virtamo, Jarmo, Smith, Alex, Kane, Eleanor, Roman, Eve, Chiu, Brian CH, Fraumeni, Joseph F, Wu, Xifeng, Cerhan, James R, Offit, Kenneth, and Chanock, Stephen J
Subjects: Humans, Membrane Glycoproteins, Computational Biology, Major Histocompatibility Complex, Genotype, Polymorphism, Single Nucleotide, European Continental Ancestry Group, Lymphoma, B-Cell, Marginal Zone, Genome-Wide Association Study, Butyrophilins, Polymorphism, Single Nucleotide, Lymphoma, B-Cell, Marginal Zone
Abstract: Marginal zone lymphoma (MZL) is the third most common subtype of B-cell non-Hodgkin lymphoma. Here we perform a two-stage GWAS of 1,281 MZL cases and 7,127 controls of European ancestry and identify two independent loci near BTNL2 (rs9461741, P=3.95 × 10(-15)) and HLA-B (rs2922994, P=2.43 × 10(-9)) in the HLA region significantly associated with MZL risk. This is the first evidence that genetic variation in the major histocompatibility complex influences MZL susceptibility.
Published: 2015

6. Genome-wide association study identifies multiple susceptibility loci for diffuse large B cell lymphoma

Author: Cerhan, James R, Berndt, Sonja I, Vijai, Joseph, Ghesquières, Hervé, McKay, James, Wang, Sophia S, Wang, Zhaoming, Yeager, Meredith, Conde, Lucia, de Bakker, Paul IW, Nieters, Alexandra, Cox, David, Burdett, Laurie, Monnereau, Alain, Flowers, Christopher R, De Roos, Anneclaire J, Brooks-Wilson, Angela R, Lan, Qing, Severi, Gianluca, Melbye, Mads, Gu, Jian, Jackson, Rebecca D, Kane, Eleanor, Teras, Lauren R, Purdue, Mark P, Vajdic, Claire M, Spinelli, John J, Giles, Graham G, Albanes, Demetrius, Kelly, Rachel S, Zucca, Mariagrazia, Bertrand, Kimberly A, Zeleniuch-Jacquotte, Anne, Lawrence, Charles, Hutchinson, Amy, Zhi, Degui, Habermann, Thomas M, Link, Brian K, Novak, Anne J, Dogan, Ahmet, Asmann, Yan W, Liebow, Mark, Thompson, Carrie A, Ansell, Stephen M, Witzig, Thomas E, Weiner, George J, Veron, Amelie S, Zelenika, Diana, Tilly, Hervé, Haioun, Corinne, Molina, Thierry Jo, Hjalgrim, Henrik, Glimelius, Bengt, Adami, Hans-Olov, Bracci, Paige M, Riby, Jacques, Smith, Martyn T, Holly, Elizabeth A, Cozen, Wendy, Hartge, Patricia, Morton, Lindsay M, Severson, Richard K, Tinker, Lesley F, North, Kari E, Becker, Nikolaus, Benavente, Yolanda, Boffetta, Paolo, Brennan, Paul, Foretova, Lenka, Maynadie, Marc, Staines, Anthony, Lightfoot, Tracy, Crouch, Simon, Smith, Alex, Roman, Eve, Diver, W Ryan, Offit, Kenneth, Zelenetz, Andrew, Klein, Robert J, Villano, Danylo J, Zheng, Tongzhang, Zhang, Yawei, Holford, Theodore R, Kricker, Anne, Turner, Jenny, Southey, Melissa C, Clavel, Jacqueline, Virtamo, Jarmo, Weinstein, Stephanie, Riboli, Elio, Vineis, Paolo, Kaaks, Rudolph, Trichopoulos, Dimitrios, Vermeulen, Roel CH, Boeing, Heiner, Tjonneland, Anne, Angelucci, Emanuele, Di Lollo, Simonetta, Rais, Marco, and Birmann, Brenda M
Subjects: Human Genome, Rare Diseases, Genetics, Cancer, Hematology, Lymphoma, Aetiology, 2.1 Biological and endogenous factors, Chromosome Mapping, Computational Biology, Genetic Loci, Genetic Predisposition to Disease, Genome-Wide Association Study, Genotype, Humans, Likelihood Functions, Lymphoma, Large B-Cell, Diffuse, Polymorphism, Single Nucleotide, Quantitative Trait Loci, White People, Biological Sciences, Medical and Health Sciences, Developmental Biology
Abstract: Diffuse large B cell lymphoma (DLBCL) is the most common lymphoma subtype and is clinically aggressive. To identify genetic susceptibility loci for DLBCL, we conducted a meta-analysis of 3 new genome-wide association studies (GWAS) and 1 previous scan, totaling 3,857 cases and 7,666 controls of European ancestry, with additional genotyping of 9 promising SNPs in 1,359 cases and 4,557 controls. In our multi-stage analysis, five independent SNPs in four loci achieved genome-wide significance marked by rs116446171 at 6p25.3 (EXOC2; P = 2.33 × 10(-21)), rs2523607 at 6p21.33 (HLA-B; P = 2.40 × 10(-10)), rs79480871 at 2p23.3 (NCOA1; P = 4.23 × 10(-8)) and two independent SNPs, rs13255292 and rs4733601, at 8q24.21 (PVT1; P = 9.98 × 10(-13) and 3.63 × 10(-11), respectively). These data provide substantial new evidence for genetic susceptibility to this B cell malignancy and point to pathways involved in immune recognition and immune function in the pathogenesis of DLBCL.
Published: 2014

7. Genome-wide Association Study Identifies Five Susceptibility Loci for Follicular Lymphoma outside the HLA Region

Author: Skibola, Christine F, Berndt, Sonja I, Vijai, Joseph, Conde, Lucia, Wang, Zhaoming, Yeager, Meredith, de Bakker, Paul IW, Birmann, Brenda M, Vajdic, Claire M, Foo, Jia-Nee, Bracci, Paige M, Vermeulen, Roel CH, Slager, Susan L, de Sanjose, Silvia, Wang, Sophia S, Linet, Martha S, Salles, Gilles, Lan, Qing, Severi, Gianluca, Hjalgrim, Henrik, Lightfoot, Tracy, Melbye, Mads, Gu, Jian, Ghesquières, Hervé, Link, Brian K, Morton, Lindsay M, Holly, Elizabeth A, Smith, Alex, Tinker, Lesley F, Teras, Lauren R, Kricker, Anne, Becker, Nikolaus, Purdue, Mark P, Spinelli, John J, Zhang, Yawei, Giles, Graham G, Vineis, Paolo, Monnereau, Alain, Bertrand, Kimberly A, Albanes, Demetrius, Zeleniuch-Jacquotte, Anne, Gabbas, Attilio, Chung, Charles C, Burdett, Laurie, Hutchinson, Amy, Lawrence, Charles, Montalvan, Rebecca, Liang, Liming, Huang, Jinyan, Ma, Baoshan, Liu, Jianjun, Adami, Hans-Olov, Glimelius, Bengt, Ye, Yuanqing, Nowakowski, Grzegorz S, Dogan, Ahmet, Thompson, Carrie A, Habermann, Thomas M, Novak, Anne J, Liebow, Mark, Witzig, Thomas E, Weiner, George J, Schenk, Maryjean, Hartge, Patricia, De Roos, Anneclaire J, Cozen, Wendy, Zhi, Degui, Akers, Nicholas K, Riby, Jacques, Smith, Martyn T, Lacher, Mortimer, Villano, Danylo J, Maria, Ann, Roman, Eve, Kane, Eleanor, Jackson, Rebecca D, North, Kari E, Diver, W Ryan, Turner, Jenny, Armstrong, Bruce K, Benavente, Yolanda, Boffetta, Paolo, Brennan, Paul, Foretova, Lenka, Maynadie, Marc, Staines, Anthony, McKay, James, Brooks-Wilson, Angela R, Zheng, Tongzhang, Holford, Theodore R, Chamosa, Saioa, Kaaks, Rudolph, Kelly, Rachel S, Ohlsson, Bodil, Travis, Ruth C, Weiderpass, Elisabete, Clavel, Jacqueline, Giovannucci, Edward, Kraft, Peter, and Virtamo, Jarmo
Subjects: Hematology, Cancer, Clinical Research, Human Genome, Lymphoma, Genetics, Rare Diseases, 2.1 Biological and endogenous factors, Aetiology, Alleles, Biomarkers, Tumor, Case-Control Studies, Chromosomes, Human, Genetic Predisposition to Disease, Genome-Wide Association Study, HLA Antigens, Haplotypes, Humans, Lymphoma, Follicular, Polymorphism, Single Nucleotide, Biological Sciences, Medical and Health Sciences, Genetics & Heredity
Abstract: Genome-wide association studies (GWASs) of follicular lymphoma (FL) have previously identified human leukocyte antigen (HLA) gene variants. To identify additional FL susceptibility loci, we conducted a large-scale two-stage GWAS in 4,523 case subjects and 13,344 control subjects of European ancestry. Five non-HLA loci were associated with FL risk: 11q23.3 (rs4938573, p = 5.79 × 10(-20)) near CXCR5; 11q24.3 (rs4937362, p = 6.76 × 10(-11)) near ETS1; 3q28 (rs6444305, p = 1.10 × 10(-10)) in LPP; 18q21.33 (rs17749561, p = 8.28 × 10(-10)) near BCL2; and 8q24.21 (rs13254990, p = 1.06 × 10(-8)) near PVT1. In an analysis of the HLA region, we identified four linked HLA-DRβ1 multiallelic amino acids at positions 11, 13, 28, and 30 that were associated with FL risk (pomnibus = 4.20 × 10(-67) to 2.67 × 10(-70)). Additional independent signals included rs17203612 in HLA class II (odds ratio [OR(per-allele)] = 1.44; p = 4.59 × 10(-16)) and rs3130437 in HLA class I (OR(per-allele) = 1.23; p = 8.23 × 10(-9)). Our findings further expand the number of loci associated with FL and provide evidence that multiple common variants outside the HLA region make a significant contribution to FL risk.
Published: 2014

8. eALPS: Estimating Abundance Levels in Pooled Sequencing Using Available Genotyping Data

Author: Eskin, Itamar, Hormozdiari, Farhad, Conde, Lucia, Riby, Jacques, Skibola, Christine F, Eskin, Eleazar, and Halperin, Eran
Subjects: Biological Sciences, Genetics, Human Genome, 2.1 Biological and endogenous factors, Aetiology, Generic health relevance, Algorithms, Escherichia coli, False Positive Reactions, Genome, Bacterial, Genome, Human, Genotyping Techniques, Humans, Lymphoma, Non-Hodgkin, Metagenome, Microbiota, Models, Genetic, Polymorphism, Single Nucleotide, Sequence Analysis, DNA, algorithms, alignment, cancer genomics, NP-completeness, Mathematical Sciences, Information and Computing Sciences, Bioinformatics, Biological sciences, Information and computing sciences, Mathematical sciences
Abstract: The recent advances in high-throughput sequencing technologies bring the potential of a better characterization of the genetic variation in humans and other organisms. In many occasions, either by design or by necessity, the sequencing procedure is performed on a pool of DNA samples with different abundances, where the abundance of each sample is unknown. Such a scenario is naturally occurring in the case of metagenomics analysis where a pool of bacteria is sequenced, or in the case of population studies involving DNA pools by design. Particularly, various pooling designs were recently suggested that can identify carriers of rare alleles in large cohorts, dramatically reducing the cost of such large-scale sequencing projects. A fundamental problem with such approaches for population studies is that the uncertainty of DNA proportions from different individuals in the pools might lead to spurious associations. Fortunately, it is often the case that the genotype data of at least some of the individuals in the pool is known. Here, we propose a method (eALPS) that uses the genotype data in conjunction with the pooled sequence data in order to accurately estimate the proportions of the samples in the pool, even in cases where not all individuals in the pool were genotyped (eALPS-LD). Using real data from a sequencing pooling study of non-Hodgkin's lymphoma, we demonstrate that the estimation of the proportions is crucial, since otherwise there is a risk for false discoveries. Additionally, we demonstrate that our approach is also applicable to the problem of quantification of species in metagenomics samples (eALPS-BCR) and is particularly suitable for metagenomic quantification of closely related species.
Published: 2013

9. Heavy Metal Contamination of Powdered Protein and Botanical Shake Mixes

Author: Skibola, Christine F., Zhang, Jianqing, and Riby, Jacques E.
Published: 2017

10. Genome-wide association study identifies multiple risk loci for chronic lymphocytic leukemia

Author: Berndt, Sonja I, Skibola, Christine F, Joseph, Vijai, Camp, Nicola J, Nieters, Alexandra, Wang, Zhaoming, Cozen, Wendy, Monnereau, Alain, Wang, Sophia S, Kelly, Rachel S, Lan, Qing, Teras, Lauren R, Chatterjee, Nilanjan, Chung, Charles C, Yeager, Meredith, Brooks-Wilson, Angela R, Hartge, Patricia, Purdue, Mark P, Birmann, Brenda M, Armstrong, Bruce K, Cocco, Pierluigi, Zhang, Yawei, Severi, Gianluca, Zeleniuch-Jacquotte, Anne, Lawrence, Charles, Burdette, Laurie, Yuenger, Jeffrey, Hutchinson, Amy, Jacobs, Kevin B, Call, Timothy G, Shanafelt, Tait D, Novak, Anne J, Kay, Neil E, Liebow, Mark, Wang, Alice H, Smedby, Karin E, Adami, Hans-Olov, Melbye, Mads, Glimelius, Bengt, Chang, Ellen T, Glenn, Martha, Curtin, Karen, Cannon-Albright, Lisa A, Jones, Brandt, Diver, W Ryan, Link, Brian K, Weiner, George J, Conde, Lucia, Bracci, Paige M, Riby, Jacques, Holly, Elizabeth A, Smith, Martyn T, Jackson, Rebecca D, Tinker, Lesley F, Benavente, Yolanda, Becker, Nikolaus, Boffetta, Paolo, Brennan, Paul, Foretova, Lenka, Maynadie, Marc, McKay, James, Staines, Anthony, Rabe, Kari G, Achenbach, Sara J, Vachon, Celine M, Goldin, Lynn R, Strom, Sara S, Lanasa, Mark C, Spector, Logan G, Leis, Jose F, Cunningham, Julie M, Weinberg, J Brice, Morrison, Vicki A, Caporaso, Neil E, Norman, Aaron D, Linet, Martha S, De Roos, Anneclaire J, Morton, Lindsay M, Severson, Richard K, Riboli, Elio, Vineis, Paolo, Kaaks, Rudolph, Trichopoulos, Dimitrios, Masala, Giovanna, Weiderpass, Elisabete, Chirlaque, María-Dolores, Vermeulen, Roel CH, Travis, Ruth C, Giles, Graham G, Albanes, Demetrius, Virtamo, Jarmo, Weinstein, Stephanie, Clavel, Jacqueline, Zheng, Tongzhang, Holford, Theodore R, Offit, Kenneth, Zelenetz, Andrew, Klein, Robert J, Spinelli, John J, and Bertrand, Kimberly A
Subjects: Cancer, Case-Control Studies, Chromosomes, Human, Pair 2, Genetic Loci, Genetic Predisposition to Disease, Genome-Wide Association Study, Humans, Leukemia, Lymphocytic, Chronic, B-Cell, Linkage Disequilibrium, Polymorphism, Single Nucleotide, Recombination, Genetic, Risk, Biological Sciences, Medical and Health Sciences, Developmental Biology
Abstract: Genome-wide association studies (GWAS) have previously identified 13 loci associated with risk of chronic lymphocytic leukemia or small lymphocytic lymphoma (CLL). To identify additional CLL susceptibility loci, we conducted the largest meta-analysis for CLL thus far, including four GWAS with a total of 3,100 individuals with CLL (cases) and 7,667 controls. In the meta-analysis, we identified ten independent associated SNPs in nine new loci at 10q23.31 (ACTA2 or FAS (ACTA2/FAS), P=1.22×10(-14)), 18q21.33 (BCL2, P=7.76×10(-11)), 11p15.5 (C11orf21, P=2.15×10(-10)), 4q25 (LEF1, P=4.24×10(-10)), 2q33.1 (CASP10 or CASP8 (CASP10/CASP8), P=2.50×10(-9)), 9p21.3 (CDKN2B-AS1, P=1.27×10(-8)), 18q21.32 (PMAIP1, P=2.51×10(-8)), 15q15.1 (BMF, P=2.71×10(-10)) and 2p22.2 (QPCT, P=1.68×10(-8)), as well as an independent signal at an established locus (2q13, ACOXL, P=2.08×10(-18)). We also found evidence for two additional promising loci below genome-wide significance at 8q22.3 (ODF1, P=5.40×10(-8)) and 5p15.33 (TERT, P=1.92×10(-7)). Although further studies are required, the proximity of several of these loci to genes involved in apoptosis suggests a plausible underlying biological mechanism.
Published: 2013

11. A meta-analysis of genome-wide association studies of follicular lymphoma

Author: Skibola, Christine F, Conde, Lucia, Foo, Jia-Nee, Riby, Jacques, Humphreys, Keith, Sillé, Fenna CM, Darabi, Hatef, Sanchez, Sylvia, Hjalgrim, Henrik, Liu, Jianjun, Bracci, Paige M, and Smedby, Karin E
Abstract: Abstract Background B-cell non-Hodgkin lymphoma represents a diverse group of hematological malignancies, of which follicular lymphoma (FL) is one of the most common subtypes. Family and epidemiological studies suggest an important genetic role in the etiology of FL. In recent genome-wide association studies (GWAS) of FL, several genetic susceptibility loci have been identified on chromosome 6p21.33 (rs6457327) and 6p21.32 (rs10484561, rs2647012) in the human leukocyte antigen class I and class II regions. To identify new genetic variants and further elucidate the genetic basis of FL, a meta-analysis was performed of the top 1000 SNPs associated with FL risk from two GWAS in the US, Denmark and Sweden (592 cases, 1541 controls), with independent validation in 107 cases and 681 controls. Results rs9275517 and rs3117222 in the HLA class II region were validated and inversely associated with FL risk (rs9275517: OR = 0.63, 95% CI = 0.55-0.73, p = 4.03 × 10-11; rs3117222: OR = 0.66, 95% CI = 0.57-0.77, p = 1.45 × 10-7). rs9275517, which is in high linkage disequilibrium with rs2647012 (r2 = 0.9), was no longer associated with FL after conditioning on rs2647012. The rs3117222 association was independent of established FL SNPs, but not of the HLA-DPB1*0301 allele. Using publicly available gene expression profiles with matching genotype information, we found that rs3117222 also was significantly correlated with increased HLA-DPB1 expression. Conclusions By performing a meta-analysis of two GWAS of FL, we further validated the relevance of HLA-DPB1*0301 as a protective allele in the pathogenesis of FL. Moreover, the protective rs3117222 A allele correlated with increased levels of HLA-DPB1, suggesting a possible disease mechanism involving HLA-DPB1 expression regulation. Our results add further support to the major role of HLA genetic variation in the pathogenesis of FL.
Published: 2012

12. GWAS of follicular lymphoma reveals allelic heterogeneity at 6p21.32 and suggests shared genetic susceptibility with diffuse large B-cell lymphoma.

Author: Smedby, Karin, Foo, Jia, Skibola, Christine, Darabi, Hatef, Conde, Lucia, Hjalgrim, Henrik, Kumar, Vikrant, Chang, Ellen, Rothman, Nathaniel, Cerhan, James, Brooks-Wilson, Angela, Rehnberg, Emil, Irwan, Ishak, Ryder, Lars, Brown, Peter, Bracci, Paige, Agana, Luz, Riby, Jacques, Cozen, Wendy, Davis, Scott, Hartge, Patricia, Morton, Lindsay, Severson, Richard, Wang, Sophia, Slager, Susan, Fredericksen, Zachary, Novak, Anne, Kay, Neil, Habermann, Thomas, Armstrong, Bruce, Kricker, Anne, Milliken, Sam, Purdue, Mark, Vajdic, Claire, Boyle, Peter, Lan, Qing, Zahm, Shelia, Zhang, Yawei, Zheng, Tongzhang, Leach, Stephen, Spinelli, John, Smith, Martyn T., Chanock, Stephen, Padyukov, Leonid, Alfredsson, Lars, Klareskog, Lars, Glimelius, Bengt, Melbye, Mads, Liu, Edison, Adami, Hans-Olov, Humphreys, Keith, and Liu, Jianjun
Subjects: Chromosomes, Human, Pair 6, Denmark, Gene Frequency, Genetic Predisposition to Disease, Genetic Variation, Genome, Human, Genome-Wide Association Study, Haplotypes, Histocompatibility Antigens Class II, Humans, Lymphoma, Follicular, Lymphoma, Large B-Cell, Diffuse, Polymorphism, Single Nucleotide, Risk Factors, Sweden
Abstract: Non-Hodgkin lymphoma (NHL) represents a diverse group of hematological malignancies, of which follicular lymphoma (FL) is a prevalent subtype. A previous genome-wide association study has established a marker, rs10484561 in the human leukocyte antigen (HLA) class II region on 6p21.32 associated with increased FL risk. Here, in a three-stage genome-wide association study, starting with a genome-wide scan of 379 FL cases and 791 controls followed by validation in 1,049 cases and 5,790 controls, we identified a second independent FL-associated locus on 6p21.32, rs2647012 (OR(combined) = 0.64, P(combined) = 2 × 10(-21)) located 962 bp away from rs10484561 (r(2)
Published: 2011

13. Genome-wide association study of follicular lymphoma identifies a risk locus at 6p21.32

Author: Conde, Lucia, Halperin, Eran, Akers, Nicholas K, Brown, Kevin M, Smedby, Karin E, Rothman, Nathaniel, Nieters, Alexandra, Slager, Susan L, Brooks-Wilson, Angela, Agana, Luz, Riby, Jacques, Liu, Jianjun, Adami, Hans-Olov, Darabi, Hatef, Hjalgrim, Henrik, Low, Hui-Qi, Humphreys, Keith, Melbye, Mads, Chang, Ellen T, Glimelius, Bengt, Cozen, Wendy, Davis, Scott, Hartge, Patricia, Morton, Lindsay M, Schenk, Maryjean, Wang, Sophia S, Armstrong, Bruce, Kricker, Anne, Milliken, Sam, Purdue, Mark P, Vajdic, Claire M, Boyle, Peter, Lan, Qing, Zahm, Shelia H, Zhang, Yawei, Zheng, Tongzhang, Becker, Nikolaus, Benavente, Yolanda, Boffetta, Paolo, Brennan, Paul, Butterbach, Katja, Cocco, Pierluigi, Foretova, Lenka, Maynadié, Marc, de Sanjosé, Silvia, Staines, Anthony, Spinelli, John J, Achenbach, Sara J, Call, Timothy G, Camp, Nicola J, Glenn, Martha, Caporaso, Neil E, Cerhan, James R, Cunningham, Julie M, Goldin, Lynn R, Hanson, Curtis A, Kay, Neil E, Lanasa, Mark C, Leis, Jose F, Marti, Gerald E, Rabe, Kari G, Rassenti, Laura Z, Spector, Logan G, Strom, Sara S, Vachon, Celine M, Weinberg, J Brice, Holly, Elizabeth A, Chanock, Stephen, Smith, Martyn T, Bracci, Paige M, and Skibola, Christine F
Subjects: Lymphoma, Prevention, Cancer, Human Genome, Genetics, Rare Diseases, Hematology, Aetiology, 2.1 Biological and endogenous factors, Disease Susceptibility, Genetic Variation, Genome-Wide Association Study, Humans, Leukemia, Lymphocytic, Chronic, B-Cell, Lymphoma, Follicular, Lymphoma, Non-Hodgkin, Major Histocompatibility Complex, Risk Factors, Biological Sciences, Medical and Health Sciences, Developmental Biology
Abstract: To identify susceptibility loci for non-Hodgkin lymphoma subtypes, we conducted a three-stage genome-wide association study. We identified two variants associated with follicular lymphoma at 6p21.32 (rs10484561, combined P = 1.12 x 10(-29) and rs7755224, combined P = 2.00 x 10(-19); r(2) = 1.0), supporting the idea that major histocompatibility complex genetic variation influences follicular lymphoma susceptibility. We also found confirmatory evidence of a previously reported association between chronic lymphocytic leukemia/small lymphocytic lymphoma and rs735665 (combined P = 4.24 x 10(-9)).
Published: 2010

14. Two high-risk susceptibility loci at 6p25.3 and 14q32.13 for Waldenström macroglobulinemia

Author: McMaster, Mary L., Berndt, Sonja I., Zhang, Jianqing, Slager, Susan L., Li, Shengchao Alfred, Vajdic, Claire M., Smedby, Karin E., Yan, Huihuang, Birmann, Brenda M., Brown, Elizabeth E., Smith, Alex, Kleinstern, Geffen, Fansler, Mervin M., Mayr, Christine, Zhu, Bin, Chung, Charles C., Park, Ju-Hyun, Burdette, Laurie, Hicks, Belynda D., Hutchinson, Amy, Teras, Lauren R., Adami, Hans-Olov, Bracci, Paige M., McKay, James, Monnereau, Alain, Link, Brian K., Vermeulen, Roel C. H., Ansell, Stephen M., Maria, Ann, Diver, W. Ryan, Melbye, Mads, Ojesina, Akinyemi I., Kraft, Peter, Boffetta, Paolo, Clavel, Jacqueline, Giovannucci, Edward, Besson, Caroline M., Canzian, Federico, Travis, Ruth C., Vineis, Paolo, Weiderpass, Elisabete, Montalvan, Rebecca, Wang, Zhaoming, Yeager, Meredith, Becker, Nikolaus, Benavente, Yolanda, Brennan, Paul, Foretova, Lenka, Maynadie, Marc, Nieters, Alexandra, de Sanjose, Silvia, Staines, Anthony, Conde, Lucia, Riby, Jacques, Glimelius, Bengt, Hjalgrim, Henrik, Pradhan, Nisha, Feldman, Andrew L., Novak, Anne J., Lawrence, Charles, Bassig, Bryan A., Lan, Qing, Zheng, Tongzhang, North, Kari E., Tinker, Lesley F., Cozen, Wendy, Severson, Richard K., Hofmann, Jonathan N., Zhang, Yawei, Jackson, Rebecca D., Morton, Lindsay M., Purdue, Mark P., Chatterjee, Nilanjan, Offit, Kenneth, Cerhan, James R., Chanock, Stephen J., Rothman, Nathaniel, Vijai, Joseph, Goldin, Lynn R., Skibola, Christine F., and Caporaso, Neil E.
Published: 2018
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15. Smoking, variation in N-acetyltransferase 1 (NAT1) and 2 (NAT2), and risk of non-Hodgkin lymphoma: a pooled analysis within the InterLymph consortium

Author: Gibson, Todd M., Smedby, Karin E., Skibola, Christine F., Hein, David W., Slager, Susan L., de Sanjosé, Silvia, Vajdic, Claire M., Zhang, Yawei, Chiu, Brian C.-H., Wang, Sophia S., Hjalgrim, Henrik, Nieters, Alexandra, Bracci, Paige M., Kricker, Anne, Zheng, Tongzhang, Kolar, Carol, Cerhan, James R., Darabi, Hatef, Becker, Nikolaus, Conde, Lucia, Holford, Theodore R., Weisenburger, Dennis D., De Roos, Anneclaire J., Butterbach, Katja, Riby, Jacques, Cozen, Wendy, Benavente, Yolanda, Palmers, Casey, Holly, Elizabeth A., Sampson, Joshua N., Rothman, Nathaniel, Armstrong, Bruce K., and Morton, Lindsay M.
Published: 2013

16. Analysis of Heritability and Shared Heritability Based on Genome-Wide Association Studies for 13 Cancer Types

Author: Sampson, Joshua N., Wheeler, William A., Yeager, Meredith, Panagiotou, Orestis, Wang, Zhaoming, Berndt, Sonja I., Lan, Qing, Abnet, Christian C., Amundadottir, Laufey T., Figueroa, Jonine D., Landi, Maria Teresa, Mirabello, Lisa, Savage, Sharon A., Taylor, Philip R., Vivo, Immaculata De, McGlynn, Katherine A., Purdue, Mark P., Rajaraman, Preetha, Adami, Hans-Olov, Ahlbom, Anders, Albanes, Demetrius, Amary, Maria Fernanda, An, She-Juan, Andersson, Ulrika, Andriole, Gerald, Jr., Andrulis, Irene L., Angelucci, Emanuele, Ansell, Stephen M., Arici, Cecilia, Armstrong, Bruce K., Arslan, Alan A., Austin, Melissa A., Baris, Dalsu, Barkauskas, Donald A., Bassig, Bryan A., Becker, Nikolaus, Benavente, Yolanda, Benhamou, Simone, Berg, Christine, Van Den Berg, David, Bernstein, Leslie, Bertrand, Kimberly A., Birmann, Brenda M., Black, Amanda, Boeing, Heiner, Boffetta, Paolo, Boutron-Ruault, Marie-Christine, Bracci, Paige M., Brinton, Louise, Brooks-Wilson, Angela R., Bueno-de-Mesquita, H. Bas, Burdett, Laurie, Buring, Julie, Butler, Mary Ann, Cai, Qiuyin, Cancel-Tassin, Geraldine, Canzian, Federico, Carrato, Alfredo, Carreon, Tania, Carta, Angela, Chan, John K. C., Chang, Ellen T., Chang, Gee-Chen, Chang, I-Shou, Chang, Jiang, Chang-Claude, Jenny, Chen, Chien-Jen, Chen, Chih-Yi, Chen, Chu, Chen, Chung-Hsing, Chen, Constance, Chen, Hongyan, Chen, Kexin, Chen, Kuan-Yu, Chen, Kun-Chieh, Chen, Ying, Chen, Ying-Hsiang, Chen, Yi-Song, Chen, Yuh-Min, Chien, Li-Hsin, Chirlaque, María-Dolores, Choi, Jin Eun, Choi, Yi Young, Chow, Wong-Ho, Chung, Charles C., Clavel, Jacqueline, Clavel-Chapelon, Françoise, Cocco, Pierluigi, Colt, Joanne S., Comperat, Eva, Conde, Lucia, Connors, Joseph M., Conti, David, Cortessis, Victoria K., Cotterchio, Michelle, Cozen, Wendy, Crouch, Simon, Crous-Bou, Marta, Cussenot, Olivier, Davis, Faith G., Ding, Ti, Diver, W. Ryan, Dorronsoro, Miren, Dossus, Laure, Duell, Eric J., Ennas, Maria Grazia, Erickson, Ralph L., Feychting, Maria, Flanagan, Adrienne M., Foretova, Lenka, Fraumeni, Joseph F., Jr, Freedman, Neal D., Beane Freeman, Laura E., Fuchs, Charles, Gago-Dominguez, Manuela, Gallinger, Steven, Gao, Yu-Tang, Gapstur, Susan M., Garcia-Closas, Montserrat, García-Closas, Reina, Gascoyne, Randy D., Gastier-Foster, Julie, Gaudet, Mia M., Gaziano, J. Michael, Giffen, Carol, Giles, Graham G., Giovannucci, Edward, Glimelius, Bengt, Goggins, Michael, Gokgoz, Nalan, Goldstein, Alisa M., Gorlick, Richard, Gross, Myron, Grubb, Robert, III, Gu, Jian, Guan, Peng, Gunter, Marc, Guo, Huan, Habermann, Thomas M., Haiman, Christopher A., Halai, Dina, Hallmans, Goran, Hassan, Manal, Hattinger, Claudia, He, Qincheng, He, Xingzhou, Helzlsouer, Kathy, Henderson, Brian, Henriksson, Roger, Hjalgrim, Henrik, Hoffman-Bolton, Judith, Hohensee, Chancellor, Holford, Theodore R., Holly, Elizabeth A., Hong, Yun-Chul, Hoover, Robert N., Horn-Ross, Pamela L., Hosain, G. M. Monawar, Hosgood, H. Dean, III, Hsiao, Chin-Fu, Hu, Nan, Hu, Wei, Hu, Zhibin, Huang, Ming-Shyan, Huerta, Jose-Maria, Hung, Jen-Yu, Hutchinson, Amy, Inskip, Peter D., Jackson, Rebecca D., Jacobs, Eric J., Jenab, Mazda, Jeon, Hyo-Sung, Ji, Bu-Tian, Jin, Guangfu, Jin, Li, Johansen, Christoffer, Johnson, Alison, Jung, Yoo Jin, Kaaks, Rudolph, Kamineni, Aruna, Kane, Eleanor, Kang, Chang Hyun, Karagas, Margaret R., Kelly, Rachel S., Khaw, Kay-Tee, Kim, Christopher, Kim, Hee Nam, Kim, Jin Hee, Kim, Jun Suk, Kim, Yeul Hong, Kim, Young Tae, Kim, Young-Chul, Kitahara, Cari M., Klein, Alison P., Klein, Robert J., Kogevinas, Manolis, Kohno, Takashi, Kolonel, Laurence N., Kooperberg, Charles, Kricker, Anne, Krogh, Vittorio, Kunitoh, Hideo, Kurtz, Robert C., Kweon, Sun-Seog, LaCroix, Andrea, Lawrence, Charles, Lecanda, Fernando, Lee, Victor Ho Fun, Li, Donghui, Li, Haixin, Li, Jihua, Li, Yao-Jen, Li, Yuqing, Liao, Linda M., Liebow, Mark, Lightfoot, Tracy, Lim, Wei-Yen, Lin, Chien-Chung, Lin, Dongxin, Lindstrom, Sara, Linet, Martha S., Link, Brian K., Liu, Chenwei, Liu, Jianjun, Liu, Li, Ljungberg, Börje, Lloreta, Josep, Lollo, Simonetta Di, Lu, Daru, Lund, Eiluv, Malats, Nuria, Mannisto, Satu, Marchand, Loic Le, Marina, Neyssa, Masala, Giovanna, Mastrangelo, Giuseppe, Matsuo, Keitaro, Maynadie, Marc, McKay, James, McKean-Cowdin, Roberta, Melbye, Mads, Melin, Beatrice S., Michaud, Dominique S., Mitsudomi, Tetsuya, Monnereau, Alain, Montalvan, Rebecca, Moore, Lee E., Mortensen, Lotte Maxild, Nieters, Alexandra, North, Kari E., Novak, Anne J., Oberg, Ann L., Offit, Kenneth, Oh, In-Jae, Olson, Sara H., Palli, Domenico, Pao, William, Park, In Kyu, Park, Jae Yong, Park, Kyong Hwa, Patiño-Garcia, Ana, Pavanello, Sofia, Peeters, Petra H. M., Perng, Reury-Perng, Peters, Ulrike, Petersen, Gloria M., Picci, Piero, Pike, Malcolm C., Porru, Stefano, Prescott, Jennifer, Prokunina-Olsson, Ludmila, Qian, Biyun, Qiao, You-Lin, Rais, Marco, Riboli, Elio, Riby, Jacques, Risch, Harvey A., Rizzato, Cosmeri, Rodabough, Rebecca, Roman, Eve, Roupret, Morgan, Ruder, Avima M., Sanjose, Silvia de, Scelo, Ghislaine, Schned, Alan, Schumacher, Fredrick, Schwartz, Kendra, Schwenn, Molly, Scotlandi, Katia, Seow, Adeline, Serra, Consol, Serra, Massimo, Sesso, Howard D., Setiawan, Veronica Wendy, Severi, Gianluca, Severson, Richard K., Shanafelt, Tait D., Shen, Hongbing, Shen, Wei, Shin, Min-Ho, Shiraishi, Kouya, Shu, Xiao-Ou, Siddiq, Afshan, Sierrasesúmaga, Luis, Sihoe, Alan Dart Loon, Skibola, Christine F., Smith, Alex, Smith, Martyn T., Southey, Melissa C., Spinelli, John J., Staines, Anthony, Stampfer, Meir, Stern, Marianna C., Stevens, Victoria L., Stolzenberg-Solomon, Rachael S., Su, Jian, Su, Wu-Chou, Sund, Malin, Sung, Jae Sook, Sung, Sook Whan, Tan, Wen, Tang, Wei, Tardón, Adonina, Thomas, David, Thompson, Carrie A., Tinker, Lesley F., Tirabosco, Roberto, Tjønneland, Anne, Travis, Ruth C., Trichopoulos, Dimitrios, Tsai, Fang-Yu, Tsai, Ying-Huang, Tucker, Margaret, Turner, Jenny, Vajdic, Claire M., Vermeulen, Roel C. H., Villano, Danylo J., Vineis, Paolo, Virtamo, Jarmo, Visvanathan, Kala, Wactawski-Wende, Jean, Wang, Chaoyu, Wang, Chih-Liang, Wang, Jiu-Cun, Wang, Junwen, Wei, Fusheng, Weiderpass, Elisabete, Weiner, George J., Weinstein, Stephanie, Wentzensen, Nicolas, White, Emily, Witzig, Thomas E., Wolpin, Brian M., Wong, Maria Pik, Wu, Chen, Wu, Guoping, Wu, Junjie, Wu, Tangchun, Wu, Wei, Wu, Xifeng, Wu, Yi-Long, Wunder, Jay S., Xiang, Yong-Bing, Xu, Jun, Xu, Ping, Yang, Pan-Chyr, Yang, Tsung-Ying, Ye, Yuanqing, Yin, Zhihua, Yokota, Jun, Yoon, Ho-Il, Yu, Chong-Jen, Yu, Herbert, Yu, Kai, Yuan, Jian-Min, Zelenetz, Andrew, Zeleniuch-Jacquotte, Anne, Zhang, Xu-Chao, Zhang, Yawei, Zhao, Xueying, Zhao, Zhenhong, Zheng, Hong, Zheng, Tongzhang, Zheng, Wei, Zhou, Baosen, Zhu, Meng, Zucca, Mariagrazia, Boca, Simina M., Cerhan, James R., Ferri, Giovanni M., Hartge, Patricia, Hsiung, Chao Agnes, Magnani, Corrado, Miligi, Lucia, Morton, Lindsay M., Smedby, Karin E., Teras, Lauren R., Vijai, Joseph, Wang, Sophia S., Brennan, Paul, Caporaso, Neil E., Hunter, David J., Kraft, Peter, Rothman, Nathaniel, Silverman, Debra T., Slager, Susan L., Chanock, Stephen J., and Chatterjee, Nilanjan
Published: 2015
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17. Perinatal development of digestive enzymes

Author: Riby, Jacques, Walker, Ann F., editor, and Rolls, Brian A., editor
Published: 1994
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18. A sandwich enzyme-linked immunosorbent assay for adducts of polycyclic aromatic hydrocarbons with human serum albumin

Author: Chung, Ming Kei, Riby, Jacques, Li, He, Iavarone, Anthony T., Williams, Evan R., Zheng, Yuxin, and Rappaport, Stephen M.
Published: 2010
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19. Enrichment of cysteinyl adducts of human serum albumin

Author: Funk, William E., Li, He, Iavarone, Anthony T., Williams, Evan R., Riby, Jacques, and Rappaport, Stephen M.
Published: 2010
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20. eALPS: Estimating Abundance Levels in Pooled Sequencing Using Available Genotyping Data

Author: Eskin, Itamar, primary, Hormozdiari, Farhad, additional, Conde, Lucia, additional, Riby, Jacques, additional, Skibola, Chris, additional, Eskin, Eleazar, additional, and Halperin, Eran, additional
Published: 2013
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21. X chromosome-wide association study of follicular lymphoma

Author: Conde, Lucia, Foo, Jia-Nee, Riby, Jacques, Liu, Jianjun, Darabi, Hatef, Hjalgrim, Henrik, Bracci, Paige M., Smedby, Karin E., and Skibola, Christine F.
Published: 2013
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22. The major cyclic trimeric product of indole-3-carbinol is a strong agonist of the estrogen receptor signaling pathway

Author: Riby, Jacques E., Feng, Chunling, Chang, Yu-Chen, Schaldach, Charlene M., Firestone, Gary L., and Bjeldanes, Leonard F.
Subjects: Estradiol -- Physiological aspects, Estrogen -- Receptors, Hormone antagonists -- Research, Cellular signal transduction -- Physiological aspects, Biological sciences, Chemistry
Abstract: Results show that the trimeric indole product is a strong agonist of estrogen receptor binding and activation. Data further indicate that it promotes proliferation of estrogen-dependent breast tumor cells and estradiol gene transcription.
Published: 2000

23. Lipoxin A4: a new class of ligand for the Ah receptor

Author: Schaldach, C.M., Riby, Jacques, and Bjeldanes, Leonard F.
Subjects: Ligands (Biochemistry) -- Research, DNA binding proteins -- Research, Biological sciences, Chemistry
Abstract: The aryl hydrocarbon (Ah) receptor is a ligand-activated transcription factor that regulates many of the biological functions of a broad class of environmental compounds. Candidate endogenous lipophilic substances were studied including the ability of the arachidonic acid metabolite, lipoxin A4, to bind to and activate the Ah receptor in Hepa-1 cells. Lipoxin A4 converted the Ah receptor to an active dioxin response element-binding form in a concentration-dependent manner.
Published: 1999

24. 3,3′-Diindolylmethane reduces levels of HIF-1α and HIF-1 activity in hypoxic cultured human cancer cells

Author: Riby, Jacques E., Firestone, Gary L., and Bjeldanes, Leonard F.
Published: 2008
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25. 3,3′-Diindolylmethane inhibits angiogenesis and the growth of transplantable human breast carcinoma in athymic mice

Author: Chang, Xiaofei, Tou, Janet C., Hong, Chibo, Kim, Hyeon-A., Riby, Jacques E., Firestone, Gary L., and Bjeldanes, Leonard F.
Published: 2005

26. Indole-3-carbinol stimulates transcription of the interferon gamma receptor 1 gene and augments interferon responsiveness in human breast cancer cells

Author: Chatterji, Urmi, Riby, Jacques E., Taniguchi, Taketoshi, Bjeldanes, Erik L., Bjeldanes, Leonard F., and Firestone, Gary L.
Published: 2004

27. Potent Ligand-Independent Estrogen Receptor Activation by 3,3′-Diindolylmethane Is Mediated by Cross Talk between the Protein Kinase A and Mitogen-Activated Protein Kinase Signaling Pathways

Author: Leong, Hoyee, Riby, Jacques E., Firestone, Gary L., and Bjeldanes, Leonard F.
Published: 2004

28. Absorption of fructose by isolated small intestine of rats is via a specific saturable carrier in the absence of glucose and by the disaccharidase-related transport system in the presence of glucose

Author: Ushijima, Kosuke, Riby, Jacques E., Fujisawa, Takuji, and Kretchmer, Norman
Subjects: Fructose in human nutrition -- Physiological aspects, Intestine, Small -- Physiological aspects, Rats -- Food and nutrition, Glucose -- Physiological aspects, Intestinal absorption -- Physiological aspects, Food/cooking/nutrition
Abstract: Previous studies have shown that the absorption of fructose is aided by simultaneous ingestion of glucose. The aim of the present study was to reproduce this finding in vitro to better understand the mechanism of the effect of glucose on absorption of fructose. The phenomena could not be reproduced with everted sleeves of rat intestine or brush border vesicles. !n a perfused segment of isolated intestine, it was possible to demonstrate that the transport of fructose was accelerated when glucose was present in the perfusion medium, The enhanced transport was inhibited by sucrose and also by acarbazone, an inhibitor of intestinal [Alpha]-disaccharidases. Phlorizin had no effect on the transport of fructose. The results of these studies indicate that there is a specific carrier for fructose saturated with a low concentration of the sugar, and that in the presence of glucose there is joint absorption of the two sugars by the disaccharidase-related transport system. INDEXING KEY WORDS: fructose; absorption; rats; isolated intestine
Published: 1995

29. Fructose absorption

Author: Riby, Jacques E., Fujisawa, Takuji, and Kretchmer, Norman
Subjects: Intestinal absorption -- Measurement, Sucrose -- Health aspects, Brush border membrane -- Physiological aspects, Membrane disorders -- Causes of, Food/cooking/nutrition, Health
Abstract: Fructose found in modern diets as a constituent of the disaccharide sucrose is absorbed by a well-characterized absorptive system integrating enzymatic hydrolysis of the disaccharide and transfer of the resulting two monosaccharides through the apical membrane of the epithelial cell. The increasing use of high-fructose syrups and crystalline fructose prompted new studies aimed at the determination of the absorptive capacity for free fructose in the human gut. Results indicate that the capacity for fructose absorption is small compared with that for sucrose and glucose and is much less than previously estimated. The unexpected finding that the simultaneous ingestion of glucose can prevent fructose malabsorption suggests that the pair of monosaccharides might be absorbed by the disaccharidase-related transport system as if they were the product of the enzymatic hydrolysis of sucrose. This absorptive mechanism might not be able to transport fructose when ingested without glucose.
Published: 1993

30. The effect of exercise on fructose absorption

Author: Fujisawa, Takuji, Mulligan, Kathleen, Wada, Leslie, Schumacher, Laurie, Riby, Jacques, and Kretchmer, Norman
Subjects: Exercise -- Health aspects, Intestinal absorption -- Physiological aspects, Fructose metabolism -- Physiological aspects, Food/cooking/nutrition, Health
Abstract: The effect of exercise on intestinal absorption of fructose was evaluated in 10 subjects after they consumed four beverages, each containing a total of 50 g carbohydrate: 100% fructose (100F), 95% fructose and 5% glucose (95F), 70% fructose and 30% glucose (70F), and 100% glucose (100G), as well as a water placebo. With 100F and 95F, breath hydrogen, which is an index of incomplete absorption, increased significantly in all subjects. In contrast, hydrogen excretion did not increase in any subject after consumption of 100G or water, or in five of seven subjects who consumed 70F. The rapid increase in hydrogen excretion observed when consumption of 100F was followed by exercise was not noted during a comparable nonexercise trial. These data suggest that intestinal capacity for absorption of fructose is readily saturated after ingestion of amounts as small as 50 g and that exercise, which reduces intestinal transit time, can cause incomplete absorption of fructose.
Published: 1993

31. Lupus-related single nucleotide polymorphisms and risk of diffuse large B-cell lymphoma

Author: Bernatsky, Sasha, primary, Velásquez García, Héctor A, additional, Spinelli, John J, additional, Gaffney, Patrick, additional, Smedby, Karin E, additional, Ramsey-Goldman, Rosalind, additional, Wang, Sophia S, additional, Adami, Hans-Olov, additional, Albanes, Demetrius, additional, Angelucci, Emanuele, additional, Ansell, Stephen M, additional, Asmann, Yan W, additional, Becker, Nikolaus, additional, Benavente, Yolanda, additional, Berndt, Sonja I, additional, Bertrand, Kimberly A, additional, Birmann, Brenda M, additional, Boeing, Heiner, additional, Boffetta, Paolo, additional, Bracci, Paige M, additional, Brennan, Paul, additional, Brooks-Wilson, Angela R, additional, Cerhan, James R, additional, Chanock, Stephen J, additional, Clavel, Jacqueline, additional, Conde, Lucia, additional, Cotenbader, Karen H, additional, Cox, David G, additional, Cozen, Wendy, additional, Crouch, Simon, additional, De Roos, Anneclaire J, additional, de Sanjose, Silvia, additional, Di Lollo, Simonetta, additional, Diver, W Ryan, additional, Dogan, Ahmet, additional, Foretova, Lenka, additional, Ghesquières, Hervé, additional, Giles, Graham G, additional, Glimelius, Bengt, additional, Habermann, Thomas M, additional, Haioun, Corinne, additional, Hartge, Patricia, additional, Hjalgrim, Henrik, additional, Holford, Theodore R, additional, Holly, Elizabeth A, additional, Jackson, Rebecca D, additional, Kaaks, Rudolph, additional, Kane, Eleanor, additional, Kelly, Rachel S, additional, Klein, Robert J, additional, Kraft, Peter, additional, Kricker, Anne, additional, Lan, Qing, additional, Lawrence, Charles, additional, Liebow, Mark, additional, Lightfoot, Tracy, additional, Link, Brian K, additional, Maynadie, Marc, additional, McKay, James, additional, Melbye, Mads, additional, Molina, Thierry J, additional, Monnereau, Alain, additional, Morton, Lindsay M, additional, Nieters, Alexandra, additional, North, Kari E, additional, Novak, Anne J, additional, Offit, Kenneth, additional, Purdue, Mark P, additional, Rais, Marco, additional, Riby, Jacques, additional, Roman, Eve, additional, Rothman, Nathaniel, additional, Salles, Gilles, additional, Severi, Gianluca, additional, Severson, Richard K, additional, Skibola, Christine F, additional, Slager, Susan L, additional, Smith, Alex, additional, Smith, Martyn T, additional, Southey, Melissa C, additional, Staines, Anthony, additional, Teras, Lauren R, additional, Thompson, Carrie A, additional, Tilly, Hervé, additional, Tinker, Lesley F, additional, Tjonneland, Anne, additional, Turner, Jenny, additional, Vajdic, Claire M, additional, Vermeulen, Roel C H, additional, Vijai, Joseph, additional, Vineis, Paolo, additional, Virtamo, Jarmo, additional, Wang, Zhaoming, additional, Weinstein, Stephanie, additional, Witzig, Thomas E, additional, Zelenetz, Andrew, additional, Zeleniuch-Jacquotte, Anne, additional, Zhang, Yawei, additional, Zheng, Tongzhang, additional, Zucca, Mariagrazia, additional, and Clarke, Ann E, additional
Published: 2017
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32. A genome-wide association study of marginal zone lymphoma shows association to the HLA region

Author: Wang, Sophia S., Becker, Nikolaus, Glimelius, Bengt, Gu, Jian, Birmann, Brenda M., North, Kari E., Riby, Jacques, Link, Brian K., Ansell, Stephen M., Slager, Susan L., de Sanjose, Silvia, Melbye, Mads, Zhang, Yawei, Brooks-Wilson, Angela R., Spinelli, John J., Lan, Qing, Vijai, Joseph, Cozen, Wendy, Skibola, Christine F., Purdue, Mark P., Wang, Zhaoming, Portlock, Carol, Teras, Lauren R., de Bakker, Paul I. W., Berndt, Sonja I., Conde, Lucia, Giles, Graham G., Vermeulen, Roel C. H., Turner, Jenny, Kelly, Rachel S., Bracci, Paige M., and Hjalgrim, Henrik
Abstract: Marginal zone lymphoma (MZL) is the third most common subtype of B-cell non-Hodgkin lymphoma. Here we perform a two-stage GWAS of 1,281 MZL cases and 7,127 controls of European ancestry and identify two independent loci near BTNL2 (rs9461741, P=3.95 × 10−15) and HLA-B (rs2922994, P=2.43 × 10−9) in the HLA region significantly associated with MZL risk. This is the first evidence that genetic variation in the major histocompatibility complex influences MZL susceptibility.
Published: 2015
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33. Analysis of Heritability and Shared Heritability Based on Genome-Wide Association Studies for 13 Cancer Types

Author: Sampson, Joshua N. Wheeler, William A. Yeager, Meredith and Panagiotou, Orestis Wang, Zhaoming Berndt, Sonja I. Lan, Qing Abnet, Christian C. Amundadottir, Laufey T. Figueroa, Jonine D. Landi, Maria Teresa Mirabello, Lisa Savage, Sharon A. Taylor, Philip R. De Vivo, Immaculata McGlynn, Katherine A. Purdue, Mark P. Rajaraman, Preetha Adami, Hans-Olov and Ahlbom, Anders Albanes, Demetrius Amary, Maria Fernanda An, She-Juan Andersson, Ulrika Andriole, Jr., Gerald Andrulis, Irene L. Angelucci, Emanuele Ansell, Stephen M. Arici, Cecilia Armstrong, Bruce K. Arslan, Alan A. Austin, Melissa A. Baris, Dalsu Barkauskas, Donald A. Bassig, Bryan A. and Becker, Nikolaus Benavente, Yolanda Benhamou, Simone Berg, Christine Van Den Berg, David Bernstein, Leslie Bertrand, Kimberly A. Birmann, Brenda M. Black, Amanda Boeing, Heiner and Boffetta, Paolo Boutron-Ruault, Marie-Christine Bracci, Paige M. Brinton, Louise Brooks-Wilson, Angela R. and Bueno-de-Mesquita, H. Bas Burdett, Laurie Buring, Julie and Butler, Mary Ann Cai, Qiuyin Cancel-Tassin, Geraldine and Canzian, Federico Carrato, Alfredo Carreon, Tania Carta, Angela Chan, John K. C. Chang, Ellen T. Chang, Gee-Chen and Chang, I-Shou Chang, Jiang Chang-Claude, Jenny Chen, Chien-Jen Chen, Chih-Yi Chen, Chu Chen, Chung-Hsing and Chen, Constance Chen, Hongyan Chen, Kexin Chen, Kuan-Yu and Chen, Kun-Chieh Chen, Ying Chen, Ying-Hsiang Chen, Yi-Song and Chen, Yuh-Min Chien, Li-Hsin Chirlaque, Maria-Dolores and Choi, Jin Eun Choi, Yi Young Chow, Wong-Ho Chung, Charles C. and Clavel, Jacqueline Clavel-Chapelon, Franoise Cocco, Pierluigi Colt, Joanne S. Comperat, Eva Conde, Lucia and Connors, Joseph M. Conti, David Cortessis, Victoria K. and Cotterchio, Michelle Cozen, Wendy Crouch, Simon Crous-Bou, Marta Cussenot, Olivier Davis, Faith G. Ding, Ti Diver, W. Ryan Dorronsoro, Miren Dossus, Laure Duell, Eric J. and Ennas, Maria Grazia Erickson, Ralph L. Feychting, Maria and Flanagan, Adrienne M. Foretova, Lenka Fraumeni, Jr., Joseph F. and Freedman, Neal D. Freeman, Laura E. Beane Fuchs, Charles and Gago-Dominguez, Manuela Gallinger, Steven Gao, Yu-Tang and Gapstur, Susan M. Garcia-Closas, Montserrat Garcia-Closas, Reina and Gascoyne, Randy D. Gastier-Foster, Julie Gaudet, Mia M. and Gaziano, J. Michael Giffen, Carol Giles, Graham G. and Giovannucci, Edward Glimelius, Bengt Goggins, Michael and Gokgoz, Nalan Goldstein, Alisa M. Gorlick, Richard Gross, Myron Grubb, III, Robert Gu, Jian Guan, Peng Gunter, Marc Guo, Huan Habermann, Thomas M. Haiman, Christopher A. and Halai, Dina Hallmans, Goran Hassan, Manal Hattinger, Claudia He, Qincheng He, Xingzhou Helzlsouer, Kathy and Henderson, Brian Henriksson, Roger Hjalgrim, Henrik and Hoffman-Bolton, Judith Hohensee, Chancellor Holford, Theodore R. and Holly, Elizabeth A. Hong, Yun-Chul Hoover, Robert N. and Horn-Ross, Pamela L. Hosain, G. M. Monawar Hosgood, III, H. Dean and Hsiao, Chin-Fu Hu, Nan Hu, Wei Hu, Zhibin Huang, Ming-Shyan Huerta, Jose-Maria Hung, Jen-Yu Hutchinson, Amy and Inskip, Peter D. Jackson, Rebecca D. Jacobs, Eric J. and Jenab, Mazda Jeon, Hyo-Sung Ji, Bu-Tian Jin, Guangfu and Jin, Li Johansen, Christoffer Johnson, Alison Jung, Yoo Jin and Kaaks, Rudolph Kamineni, Aruna Kane, Eleanor Kang, Chang Hyun Karagas, Margaret R. Kelly, Rachel S. Khaw, Kay-Tee and Kim, Christopher Kim, Hee Nam Kim, Jin Hee Kim, Jun Suk and Kim, Yeul Hong Kim, Young Tae Kim, Young-Chul Kitahara, Cari M. Klein, Alison P. Klein, Robert J. Kogevinas, Manolis and Kohno, Takashi Kolonel, Laurence N. Kooperberg, Charles and Kricker, Anne Krogh, Vittorio Kunitoh, Hideo Kurtz, Robert C. Kweon, Sun-Seog LaCroix, Andrea Lawrence, Charles and Lecanda, Fernando Lee, Victor Ho Fun Li, Donghui Li, Haixin and Li, Jihua Li, Yao-Jen Li, Yuqing Liao, Linda M. and Liebow, Mark Lightfoot, Tracy Lim, Wei-Yen Lin, Chien-Chung and Lin, Dongxin Lindstrom, Sara Linet, Martha S. Link, Brian K. Liu, Chenwei Liu, Jianjun Liu, Li Ljungberg, Boerje Lloreta, Josep Di Lollo, Simonetta Lu, Daru Lund, Eiluv Malats, Nuria Mannisto, Satu Le Marchand, Loic and Marina, Neyssa Masala, Giovanna Mastrangelo, Giuseppe and Matsuo, Keitaro Maynadie, Marc Mckay, James McKean-Cowdin, Roberta Melbye, Mads Melin, Beatrice S. Michaud, Dominique S. Mitsudomi, Tetsuya Monnereau, Alain Montalvan, Rebecca and Moore, Lee E. Mortensen, Lotte Maxild Nieters, Alexandra and North, Kari E. Novak, Anne J. Oberg, Ann L. Offit, Kenneth and Oh, In-Jae Olson, Sara H. Palli, Domenico Pao, William and Park, In Kyu Park, Jae Yong Park, Kyong Hwa and Patino-Garcia, Ana Pavanello, Sofia Peeters, Petra H. M. and Perng, Reury-Perng Peters, Ulrike Petersen, Gloria M. Picci, Piero Pike, Malcolm C. Porru, Stefano Prescott, Jennifer and Prokunina-Olsson, Ludmila Qian, Biyun Qiao, You-Lin Rais, Marco Riboli, Elio Riby, Jacques Risch, Harvey A. and Rizzato, Cosmeri Rodabough, Rebecca Roman, Eve Roupret, Morgan Ruder, Avima M. de Sanjose, Silvia Scelo, Ghislaine and Schned, Alan Schumacher, Fredrick Schwartz, Kendra and Schwenn, Molly Scotlandi, Katia Seow, Adeline Serra, Consol and Serra, Massimo Sesso, Howard D. Setiawan, Veronica Wendy and Severi, Gianluca Severson, Richard K. Shanafelt, Tait D. and Shen, Hongbing Shen, Wei Shin, Min-Ho Shiraishi, Kouya and Shu, Xiao-Ou Siddiq, Afshan Sierrasesumaga, Luis Sihoe, Alan Dart Loon Skibola, Christine F. Smith, Alex Smith, Martyn T. and Southey, Melissa C. Spinelli, John J. Staines, Anthony and Stampfer, Meir Stern, Marianna C. Stevens, Victoria L. and Stolzenberg-Solomon, Rachael S. Su, Jian Su, Wu-Chou Sund, Malin Sung, Jae Sook Sung, Sook Whan Tan, Wen Tang, Wei and Tardon, Adonina Thomas, David Thompson, Carrie A. and Tinker, Lesley F. Tirabosco, Roberto Tjonneland, Anne and Travis, Ruth C. Trichopoulos, Dimitrios Tsai, Fang-Yu Tsai, Ying-Huang Tucker, Margaret Turner, Jenny Vajdic, Claire M. and Vermeulen, Roel C. H. Villano, Danylo J. Vineis, Paolo and Virtamo, Jarmo Visvanathan, Kala Wactawski-Wende, Jean Wang, Chaoyu Wang, Chih-Liang Wang, Jiu-Cun Wang, Junwen Wei, Fusheng Weiderpass, Elisabete Weiner, George J. Weinstein, Stephanie Wentzensen, Nicolas White, Emily Witzig, Thomas E. and Wolpin, Brian M. Wong, Maria Pik Wu, Chen Wu, Guoping and Wu, Junjie Wu, Tangchun Wu, Wei Wu, Xifeng Wu, Yi-Long Wunder, Jay S. Xiang, Yong-Bing Xu, Jun Xu, Ping and Yang, Pan-Chyr Yang, Tsung-Ying Ye, Yuanqing Yin, Zhihua and Yokota, Jun Yoon, Ho-Il Yu, Chong-Jen Yu, Herbert and Yu, Kai Yuan, Jian-Min Zelenetz, Andrew Zeleniuch-Jacquotte, Anne Zhang, Xu-Chao Zhang, Yawei Zhao, Xueying Zhao, Zhenhong Zheng, Hong Zheng, Tongzhang Zheng, Wei Zhou, Baosen Zhu, Meng Zucca, Mariagrazia Boca, Simina M. and Cerhan, James R. Ferri, Giovanni M. Hartge, Patricia Hsiung, Chao Agnes Magnani, Corrado Miligi, Lucia Morton, Lindsay M. and Smedby, Karin E. Teras, Lauren R. Vijai, Joseph Wang, Sophia S. Brennan, Paul Caporaso, Neil E. Hunter, David J. and Kraft, Peter Rothman, Nathaniel Silverman, Debra T. and Slager, Susan L. Chanock, Stephen J. Chatterjee, Nilanjan
Abstract: Background: Studies of related individuals have consistently demonstrated notable familial aggregation of cancer. We aim to estimate the heritability and genetic correlation attributable to the additive effects of common single-nucleotide polymorphisms (SNPs) for cancer at 13 anatomical sites. Methods: Between 2007 and 2014, the US National Cancer Institute has generated data from genome-wide association studies (GWAS) for 49 492 cancer case patients and 34 131 control patients. We apply novel mixed model methodology (GCTA) to this GWAS data to estimate the heritability of individual cancers, as well as the proportion of heritability attributable to cigarette smoking in smoking-related cancers, and the genetic correlation between pairs of cancers. Results: GWAS heritability was statistically significant at nearly all sites, with the estimates of array-based heritability, h(l)(2), on the liability threshold (LT) scale ranging from 0.05 to 0.38. Estimating the combined heritability of multiple smoking characteristics, we calculate that at least 24% (95% confidence interval [CI] = 14% to 37%) and 7% (95% CI = 4% to 11%) of the heritability for lung and bladder cancer, respectively, can be attributed to genetic determinants of smoking. Most pairs of cancers studied did not show evidence of strong genetic correlation. We found only four pairs of cancers with marginally statistically significant correlations, specifically kidney and testes (rho = 0.73, SE = 0.28), diffuse large B-cell lymphoma (DLBCL) and pediatric osteosarcoma (rho = 0.53, SE = 0.21), DLBCL and chronic lymphocytic leukemia (CLL) (rho = 0.51, SE = 0.18), and bladder and lung (rho = 0.35, SE = 0.14). Correlation analysis also indicates that the genetic architecture of lung cancer differs between a smoking population of European ancestry and a nonsmoking Asian population, allowing for the possibility that the genetic etiology for the same disease can vary by population and environmental exposures. Conclusion: Our results provide important insights into the genetic architecture of cancers and suggest new avenues for investigation.
Published: 2015

34. Genome-wide Association Study Identifies Five Susceptibility Loci for Follicular Lymphoma outside the HLA Region

Author: Skibola, Christine F., Berndt, Sonja I., Vijai, Joseph, Conde, Lucia, Wang, Zhaoming, Yeager, Meredith, de Bakker, Paul I. W., Birmann, Brenda M., Vajdic, Claire M., Foo, Jia-Nee, Bracci, Paige M., Vermeulen, Roel C. H., Slager, Susan L., de Sanjose, Silvia, Wang, Sophia S., Linet, Martha S., Salles, Gilles, Lan, Qing, Severi, Gianluca, Hjalgrim, Henrik, Lightfoot, Tracy, Melbye, Mads, Gu, Jian, Ghesquieres, Herve, Link, Brian K., Morton, Lindsay M., Holly, Elizabeth A., Smith, Alex, Tinker, Lesley F., Teras, Lauren R., Kricker, Anne, Becker, Nikolaus, Purdue, Mark P., Spinelli, John J., Zhang, Yawei, Giles, Graham G., Vineis, Paolo, Monnereau, Alain, Bertrand, Kimberly A., Albanes, Demetrius, Zeleniuch-Jacquotte, Anne, Gabbas, Attilio, Chung, Charles C., Burdett, Laurie, Hutchinson, Amy, Lawrence, Charles, Montalvan, Rebecca, Liang, Liming, Huang, Jinyan, Ma, Baoshan, Liu, Jianjun, Adami, Hans-Olov, Glimelius, Bengt, Ye, Yuanqing, Nowakowski, Grzegorz S., Dogan, Ahmet, Thompson, Carrie A., Habermann, Thomas M., Novak, Anne J., Liebow, Mark, Witzig, Thomas E., Weiner, George J., Schenk, Maryjean, Hartge, Patricia, De Roos, Anneclaire J., Cozen, Wendy, Zhi, Degui, Akers, Nicholas K., Riby, Jacques, Smith, Martyn T., Lacher, Mortimer, Villano, Danylo J., Maria, Ann, Roman, Eve, Kane, Eleanor, Jackson, Rebecca D., North, Kari E., Diver, W. Ryan, Turner, Jenny, Armstrong, Bruce K., Benavente, Yolanda, Boffetta, Paolo, Brennan, Paul, Foretova, Lenka, Maynadie, Marc, Staines, Anthony, McKay, James, Brooks-Wilson, Angela R., Zheng, Tongzhang, Holford, Theodore R., Chamosa, Saioa, Kaaks, Rudolph, Kelly, Rachel S., Ohlsson, Bodil, Travis, Ruth C., Weiderpass, Elisabete, Clave, Jacqueline, Giovannucci, Edward, Kraft, Peter, Virtamo, Jarmo, Mazza, Patrizio, Cocco, Pierluigi, Ennas, Maria Grazia, Chiu, Brian C. H., Fraumeni, Joseph R., Nieters, Alexandra, Offit, Kenneth, Wu, Xifeng, Cerhan, James R., Smedby, Karin E., Chanock, Stephen J., Rothman, Nathaniel, LS IRAS EEPI GRA (Gezh.risico-analyse), Risk Assessment of Toxic and Immunomodulatory Agents, and IRAS RATIA-SIB
Subjects: EXPRESSION, RISK, CLASS-I, RESOURCE, TOOL, UNIVERSITY, PEPTIDE, VARIANTS, SET, SNPS
Abstract: Genome-wide association studies (GWASs) of follicular lymphoma (FL) have previously identified human leukocyte antigen (HLA) gene variants. To identify additional FL susceptibility loci, we conducted a large-scale two-stage GWAS in 4,523 case subjects and 13,344 control subjects of European ancestry. Five non-HLA loci were associated with FL risk: 11q23.3 (rs4938573, p = 5.79 x 10(-20)) near CXCR5; 11q24.3 (rs4937362, p = 6.76 x 10(-11)) near ETS1; 3q28 (rs6444305, p = 1.10 x 10(-10)) in LPP; 18q21.33 (rs17749561, p = 8.28 x 10(-10)) near BCL2; and 8q24.21 (rs13254990, p = 1.06 x 10(-8)) near PVT1. In an analysis of the HLA region, we identified four linked HLA-DR beta 1 multiallelic amino acids at positions 11, 13, 28, and 30 that were associated with FL risk (P-omnibus = 4.20 x 10(-67) to 2.67 x 10(-70)). Additional independent signals included rs17203612 in HLA class II (odds ratio [ORper-allele] = 1.44; p = 4.59 x 10(-16)) and rs3130437 in HLA class I (ORper-allele = 1.23; p = 8.23 x 10(-9)). Our findings further expand the number of loci associated with FL and provide evidence that multiple common variants outside the HLA region make a significant contribution to FL risk.
Published: 2014

35. Genome-wide association study identifies multiple susceptibility loci for diffuse large B cell lymphoma

Author: Cerhan, James R., Berndt, Sonja I., Vijai, Joseph, Ghesquières, Hervé, McKay, James, Wang, Sophia S., Wang, Zhaoming, Yeager, Meredith, Conde, Lucia, De Bakker, Paul I W, Nieters, Alexandra, Cox, David, Burdett, Laurie, Monnereau, Alain, Flowers, Christopher R., De Roos, Anneclaire J., Brooks-Wilson, Angela R., Lan, Qing, Severi, Gianluca, Melbye, Mads, Gu, Jian, Jackson, Rebecca D., Kane, Eleanor, Teras, Lauren R., Purdue, Mark P., Vajdic, Claire M., Spinelli, John J., Giles, Graham G., Albanes, Demetrius, Kelly, Rachel S., Zucca, Mariagrazia, Bertrand, Kimberly A., Zeleniuch-Jacquotte, Anne, Lawrence, Charles, Hutchinson, Amy, Zhi, Degui, Habermann, Thomas M., Link, Brian K., Novak, Anne J., Dogan, Ahmet, Asmann, Yan W., Liebow, Mark, Thompson, Carrie A., Ansell, Stephen M., Witzig, Thomas E., Weiner, George J., Veron, Amelie S., Zelenika, Diana, Tilly, Hervé, Haioun, Corinne, Molina, Thierry Jo, Hjalgrim, Henrik, Glimelius, Bengt, Adami, Hans Olov, Bracci, Paige M., Riby, Jacques, Smith, Martyn T., Holly, Elizabeth A., Cozen, Wendy, Hartge, Patricia, Morton, Lindsay M., Severson, Richard K., Tinker, Lesley F., North, Kari E., Becker, Nikolaus, Benavente, Yolanda, Boffetta, Paolo, Brennan, Paul, Foretova, Lenka, Maynadie, Marc, Staines, Anthony, Lightfoot, Tracy, Crouch, Simon, Smith, Alex, Roman, Eve, Diver, W. Ryan, Offit, Kenneth, Zelenetz, Andrew, Klein, Robert J., Villano, Danylo J., Zheng, Tongzhang, Zhang, Yawei, Holford, Theodore R., Kricker, Anne, Turner, Jenny, Southey, Melissa C., Clavel, Jacqueline, Virtamo, Jarmo, Weinstein, Stephanie, Riboli, Elio, Vineis, Paolo, Kaaks, Rudolph, Trichopoulos, Dimitrios, Vermeulen, Roel C H, Boeing, Heiner, Tjonneland, Anne, Angelucci, Emanuele, Di Lollo, Simonetta, Rais, Marco, Birmann, Brenda M., Laden, Francine, Giovannucci, Edward, Kraft, Peter, Huang, Jinyan, Ma, Baoshan, Ye, Yuanqing, Chiu, Brian C H, Sampson, Joshua, Liang, Liming, Park, Ju Hyun, Chung, Charles C., Weisenburger, Dennis D., Chatterjee, Nilanjan, Fraumeni, Joseph F., Slager, Susan L., Wu, Xifeng, De Sanjose, Silvia, Smedby, Karin E., Salles, Gilles, Skibola, Christine F., Rothman, Nathaniel, Chanock, Stephen J., LS IRAS EEPI GRA (Gezh.risico-analyse), Risk Assessment of Toxic and Immunomodulatory Agents, and IRAS RATIA-SIB
Abstract: Diffuse large B cell lymphoma (DLBCL) is the most common lymphoma subtype and is clinically aggressive. To identify genetic susceptibility loci for DLBCL, we conducted a meta-analysis of 3 new genome-wide association studies (GWAS) and 1 previous scan, totaling 3,857 cases and 7,666 controls of European ancestry, with additional genotyping of 9 promising SNPs in 1,359 cases and 4,557 controls. In our multi-stage analysis, five independent SNPs in four loci achieved genome-wide significance marked by rs116446171 at 6p25.3 (EXOC2; P = 2.33 × 10 '21), rs2523607 at 6p21.33 (HLA-B; P = 2.40 × 10 '10), rs79480871 at 2p23.3 (NCOA1; P = 4.23 × 10 '8) and two independent SNPs, rs13255292 and rs4733601, at 8q24.21 (PVT1; P = 9.98 × 10 '13 and 3.63 × 10 '11, respectively). These data provide substantial new evidence for genetic susceptibility to this B cell malignancy and point to pathways involved in immune recognition and immune function in the pathogenesis of DLBCL.
Published: 2014

36. Serum protein profiling in diffuse large B-cell lymphoma

Author: Riby, Jacques, primary, Mobley, James, additional, Zhang, Jianqing, additional, Bracci, Paige M., additional, and Skibola, Christine F., additional
Published: 2016
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37. A Fucus vesiculosus extract inhibits estrogen receptor activation and induces cell death in female cancer cell lines

Author: Zhang, Jianqing, primary, Riby, Jacques E., additional, Conde, Lucia, additional, Grizzle, William E., additional, Cui, Xiangqin, additional, and Skibola, Christine F., additional
Published: 2016
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38. Meta-analysis of genome-wide association studies discovers multiple loci for chronic lymphocytic leukemia

Author: Berndt, Sonja I., primary, Camp, Nicola J., additional, Skibola, Christine F., additional, Vijai, Joseph, additional, Wang, Zhaoming, additional, Gu, Jian, additional, Nieters, Alexandra, additional, Kelly, Rachel S., additional, Smedby, Karin E., additional, Monnereau, Alain, additional, Cozen, Wendy, additional, Cox, Angela, additional, Wang, Sophia S., additional, Lan, Qing, additional, Teras, Lauren R., additional, Machado, Moara, additional, Yeager, Meredith, additional, Brooks-Wilson, Angela R., additional, Hartge, Patricia, additional, Purdue, Mark P., additional, Birmann, Brenda M., additional, Vajdic, Claire M., additional, Cocco, Pierluigi, additional, Zhang, Yawei, additional, Giles, Graham G., additional, Zeleniuch-Jacquotte, Anne, additional, Lawrence, Charles, additional, Montalvan, Rebecca, additional, Burdett, Laurie, additional, Hutchinson, Amy, additional, Ye, Yuanqing, additional, Call, Timothy G., additional, Shanafelt, Tait D., additional, Novak, Anne J., additional, Kay, Neil E., additional, Liebow, Mark, additional, Cunningham, Julie M., additional, Allmer, Cristine, additional, Hjalgrim, Henrik, additional, Adami, Hans-Olov, additional, Melbye, Mads, additional, Glimelius, Bengt, additional, Chang, Ellen T., additional, Glenn, Martha, additional, Curtin, Karen, additional, Cannon-Albright, Lisa A., additional, Diver, W Ryan, additional, Link, Brian K., additional, Weiner, George J., additional, Conde, Lucia, additional, Bracci, Paige M., additional, Riby, Jacques, additional, Arnett, Donna K., additional, Zhi, Degui, additional, Leach, Justin M., additional, Holly, Elizabeth A., additional, Jackson, Rebecca D., additional, Tinker, Lesley F., additional, Benavente, Yolanda, additional, Sala, Núria, additional, Casabonne, Delphine, additional, Becker, Nikolaus, additional, Boffetta, Paolo, additional, Brennan, Paul, additional, Foretova, Lenka, additional, Maynadie, Marc, additional, McKay, James, additional, Staines, Anthony, additional, Chaffee, Kari G., additional, Achenbach, Sara J., additional, Vachon, Celine M., additional, Goldin, Lynn R., additional, Strom, Sara S., additional, Leis, Jose F., additional, Weinberg, J. Brice, additional, Caporaso, Neil E., additional, Norman, Aaron D., additional, De Roos, Anneclaire J., additional, Morton, Lindsay M., additional, Severson, Richard K., additional, Riboli, Elio, additional, Vineis, Paolo, additional, Kaaks, Rudolph, additional, Masala, Giovanna, additional, Weiderpass, Elisabete, additional, Chirlaque, María- Dolores, additional, Vermeulen, Roel C. H., additional, Travis, Ruth C., additional, Southey, Melissa C., additional, Milne, Roger L., additional, Albanes, Demetrius, additional, Virtamo, Jarmo, additional, Weinstein, Stephanie, additional, Clavel, Jacqueline, additional, Zheng, Tongzhang, additional, Holford, Theodore R., additional, Villano, Danylo J., additional, Maria, Ann, additional, Spinelli, John J., additional, Gascoyne, Randy D., additional, Connors, Joseph M., additional, Bertrand, Kimberly A., additional, Giovannucci, Edward, additional, Kraft, Peter, additional, Kricker, Anne, additional, Turner, Jenny, additional, Ennas, Maria Grazia, additional, Ferri, Giovanni M., additional, Miligi, Lucia, additional, Liang, Liming, additional, Ma, Baoshan, additional, Huang, Jinyan, additional, Crouch, Simon, additional, Park, Ju-Hyun, additional, Chatterjee, Nilanjan, additional, North, Kari E., additional, Snowden, John A., additional, Wright, Josh, additional, Fraumeni, Joseph F., additional, Offit, Kenneth, additional, Wu, Xifeng, additional, de Sanjose, Silvia, additional, Cerhan, James R., additional, Chanock, Stephen J., additional, Rothman, Nathaniel, additional, and Slager, Susan L., additional
Published: 2016
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39. Analysis of Heritability and Shared Heritability Based on Genome-Wide Association Studies for Thirteen Cancer Types

Author: Sampson, Joshua N., primary, Wheeler, William A., additional, Yeager, Meredith, additional, Panagiotou, Orestis, additional, Wang, Zhaoming, additional, Berndt, Sonja I., additional, Lan, Qing, additional, Abnet, Christian C., additional, Amundadottir, Laufey T., additional, Figueroa, Jonine D., additional, Landi, Maria Teresa, additional, Mirabello, Lisa, additional, Savage, Sharon A., additional, Taylor, Philip R., additional, Vivo, Immaculata De, additional, McGlynn, Katherine A., additional, Purdue, Mark P., additional, Rajaraman, Preetha, additional, Adami, Hans-Olov, additional, Ahlbom, Anders, additional, Albanes, Demetrius, additional, Amary, Maria Fernanda, additional, An, She-Juan, additional, Andersson, Ulrika, additional, Andriole, Gerald, additional, Andrulis, Irene L., additional, Angelucci, Emanuele, additional, Ansell, Stephen M., additional, Arici, Cecilia, additional, Armstrong, Bruce K., additional, Arslan, Alan A., additional, Austin, Melissa A., additional, Baris, Dalsu, additional, Barkauskas, Donald A., additional, Bassig, Bryan A., additional, Becker, Nikolaus, additional, Benavente, Yolanda, additional, Benhamou, Simone, additional, Berg, Christine, additional, Van Den Berg, David, additional, Bernstein, Leslie, additional, Bertrand, Kimberly A., additional, Birmann, Brenda M., additional, Black, Amanda, additional, Boeing, Heiner, additional, Boffetta, Paolo, additional, Boutron-Ruault, Marie-Christine, additional, Bracci, Paige M., additional, Brinton, Louise, additional, Brooks-Wilson, Angela R., additional, Bueno-de-Mesquita, H. Bas, additional, Burdett, Laurie, additional, Buring, Julie, additional, Butler, Mary Ann, additional, Cai, Qiuyin, additional, Cancel-Tassin, Geraldine, additional, Canzian, Federico, additional, Carrato, Alfredo, additional, Carreon, Tania, additional, Carta, Angela, additional, Chan, John K. C., additional, Chang, Ellen T., additional, Chang, Gee-Chen, additional, Chang, I-Shou, additional, Chang, Jiang, additional, Chang-Claude, Jenny, additional, Chen, Chien-Jen, additional, Chen, Chih-Yi, additional, Chen, Chu, additional, Chen, Chung-Hsing, additional, Chen, Constance, additional, Chen, Hongyan, additional, Chen, Kexin, additional, Chen, Kuan-Yu, additional, Chen, Kun-Chieh, additional, Chen, Ying, additional, Chen, Ying-Hsiang, additional, Chen, Yi-Song, additional, Chen, Yuh-Min, additional, Chien, Li-Hsin, additional, Chirlaque, María-Dolores, additional, Choi, Jin Eun, additional, Choi, Yi Young, additional, Chow, Wong-Ho, additional, Chung, Charles C., additional, Clavel, Jacqueline, additional, Clavel-Chapelon, Françoise, additional, Cocco, Pierluigi, additional, Colt, Joanne S., additional, Comperat, Eva, additional, Conde, Lucia, additional, Connors, Joseph M., additional, Conti, David, additional, Cortessis, Victoria K., additional, Cotterchio, Michelle, additional, Cozen, Wendy, additional, Crouch, Simon, additional, Crous-Bou, Marta, additional, Cussenot, Olivier, additional, Davis, Faith G., additional, Ding, Ti, additional, Diver, W. Ryan, additional, Dorronsoro, Miren, additional, Dossus, Laure, additional, Duell, Eric J., additional, Ennas, Maria Grazia, additional, Erickson, Ralph L., additional, Feychting, Maria, additional, Flanagan, Adrienne M., additional, Foretova, Lenka, additional, Fraumeni, Joseph F., additional, Freedman, Neal D., additional, Beane Freeman, Laura E., additional, Fuchs, Charles, additional, Gago-Dominguez, Manuela, additional, Gallinger, Steven, additional, Gao, Yu-Tang, additional, Gapstur, Susan M., additional, Garcia-Closas, Montserrat, additional, García-Closas, Reina, additional, Gascoyne, Randy D., additional, Gastier-Foster, Julie, additional, Gaudet, Mia M., additional, Gaziano, J. Michael, additional, Giffen, Carol, additional, Giles, Graham G., additional, Giovannucci, Edward, additional, Glimelius, Bengt, additional, Goggins, Michael, additional, Gokgoz, Nalan, additional, Goldstein, Alisa M., additional, Gorlick, Richard, additional, Gross, Myron, additional, Grubb, Robert, additional, Gu, Jian, additional, Guan, Peng, additional, Gunter, Marc, additional, Guo, Huan, additional, Habermann, Thomas M., additional, Haiman, Christopher A., additional, Halai, Dina, additional, Hallmans, Goran, additional, Hassan, Manal, additional, Hattinger, Claudia, additional, He, Qincheng, additional, He, Xingzhou, additional, Helzlsouer, Kathy, additional, Henderson, Brian, additional, Henriksson, Roger, additional, Hjalgrim, Henrik, additional, Hoffman-Bolton, Judith, additional, Hohensee, Chancellor, additional, Holford, Theodore R., additional, Holly, Elizabeth A., additional, Hong, Yun-Chul, additional, Hoover, Robert N., additional, Horn-Ross, Pamela L., additional, Hosain, G. M. Monawar, additional, Hosgood, H. Dean, additional, Hsiao, Chin-Fu, additional, Hu, Nan, additional, Hu, Wei, additional, Hu, Zhibin, additional, Huang, Ming-Shyan, additional, Huerta, Jose-Maria, additional, Hung, Jen-Yu, additional, Hutchinson, Amy, additional, Inskip, Peter D., additional, Jackson, Rebecca D., additional, Jacobs, Eric J., additional, Jenab, Mazda, additional, Jeon, Hyo-Sung, additional, Ji, Bu-Tian, additional, Jin, Guangfu, additional, Jin, Li, additional, Johansen, Christoffer, additional, Johnson, Alison, additional, Jung, Yoo Jin, additional, Kaaks, Rudolph, additional, Kamineni, Aruna, additional, Kane, Eleanor, additional, Kang, Chang Hyun, additional, Karagas, Margaret R., additional, Kelly, Rachel S., additional, Khaw, Kay-Tee, additional, Kim, Christopher, additional, Kim, Hee Nam, additional, Kim, Jin Hee, additional, Kim, Jun Suk, additional, Kim, Yeul Hong, additional, Kim, Young Tae, additional, Kim, Young-Chul, additional, Kitahara, Cari M., additional, Klein, Alison P., additional, Klein, Robert J., additional, Kogevinas, Manolis, additional, Kohno, Takashi, additional, Kolonel, Laurence N., additional, Kooperberg, Charles, additional, Kricker, Anne, additional, Krogh, Vittorio, additional, Kunitoh, Hideo, additional, Kurtz, Robert C., additional, Kweon, Sun-Seog, additional, LaCroix, Andrea, additional, Lawrence, Charles, additional, Lecanda, Fernando, additional, Lee, Victor Ho Fun, additional, Li, Donghui, additional, Li, Haixin, additional, Li, Jihua, additional, Li, Yao-Jen, additional, Li, Yuqing, additional, Liao, Linda M., additional, Liebow, Mark, additional, Lightfoot, Tracy, additional, Lim, Wei-Yen, additional, Lin, Chien-Chung, additional, Lin, Dongxin, additional, Lindstrom, Sara, additional, Linet, Martha S., additional, Link, Brian K., additional, Liu, Chenwei, additional, Liu, Jianjun, additional, Liu, Li, additional, Ljungberg, Börje, additional, Lloreta, Josep, additional, Lollo, Simonetta Di, additional, Lu, Daru, additional, Lund, Eiluv, additional, Malats, Nuria, additional, Mannisto, Satu, additional, Marchand, Loic Le, additional, Marina, Neyssa, additional, Masala, Giovanna, additional, Mastrangelo, Giuseppe, additional, Matsuo, Keitaro, additional, Maynadie, Marc, additional, McKay, James, additional, McKean-Cowdin, Roberta, additional, Melbye, Mads, additional, Melin, Beatrice S., additional, Michaud, Dominique S., additional, Mitsudomi, Tetsuya, additional, Monnereau, Alain, additional, Montalvan, Rebecca, additional, Moore, Lee E., additional, Mortensen, Lotte Maxild, additional, Nieters, Alexandra, additional, North, Kari E., additional, Novak, Anne J., additional, Oberg, Ann L., additional, Offit, Kenneth, additional, Oh, In-Jae, additional, Olson, Sara H., additional, Palli, Domenico, additional, Pao, William, additional, Park, In Kyu, additional, Park, Jae Yong, additional, Park, Kyong Hwa, additional, Patiño-Garcia, Ana, additional, Pavanello, Sofia, additional, Peeters, Petra H. M., additional, Perng, Reury-Perng, additional, Peters, Ulrike, additional, Petersen, Gloria M., additional, Picci, Piero, additional, Pike, Malcolm C., additional, Porru, Stefano, additional, Prescott, Jennifer, additional, Prokunina-Olsson, Ludmila, additional, Qian, Biyun, additional, Qiao, You-Lin, additional, Rais, Marco, additional, Riboli, Elio, additional, Riby, Jacques, additional, Risch, Harvey A., additional, Rizzato, Cosmeri, additional, Rodabough, Rebecca, additional, Roman, Eve, additional, Roupret, Morgan, additional, Ruder, Avima M., additional, Sanjose, Silvia de, additional, Scelo, Ghislaine, additional, Schned, Alan, additional, Schumacher, Fredrick, additional, Schwartz, Kendra, additional, Schwenn, Molly, additional, Scotlandi, Katia, additional, Seow, Adeline, additional, Serra, Consol, additional, Serra, Massimo, additional, Sesso, Howard D., additional, Setiawan, Veronica Wendy, additional, Severi, Gianluca, additional, Severson, Richard K., additional, Shanafelt, Tait D., additional, Shen, Hongbing, additional, Shen, Wei, additional, Shin, Min-Ho, additional, Shiraishi, Kouya, additional, Shu, Xiao-Ou, additional, Siddiq, Afshan, additional, Sierrasesúmaga, Luis, additional, Sihoe, Alan Dart Loon, additional, Skibola, Christine F., additional, Smith, Alex, additional, Smith, Martyn T., additional, Southey, Melissa C., additional, Spinelli, John J., additional, Staines, Anthony, additional, Stampfer, Meir, additional, Stern, Marianna C., additional, Stevens, Victoria L., additional, Stolzenberg-Solomon, Rachael S., additional, Su, Jian, additional, Su, Wu-Chou, additional, Sund, Malin, additional, Sung, Jae Sook, additional, Sung, Sook Whan, additional, Tan, Wen, additional, Tang, Wei, additional, Tardón, Adonina, additional, Thomas, David, additional, Thompson, Carrie A., additional, Tinker, Lesley F., additional, Tirabosco, Roberto, additional, Tjønneland, Anne, additional, Travis, Ruth C., additional, Trichopoulos, Dimitrios, additional, Tsai, Fang-Yu, additional, Tsai, Ying-Huang, additional, Tucker, Margaret, additional, Turner, Jenny, additional, Vajdic, Claire M., additional, Vermeulen, Roel C. H., additional, Villano, Danylo J., additional, Vineis, Paolo, additional, Virtamo, Jarmo, additional, Visvanathan, Kala, additional, Wactawski-Wende, Jean, additional, Wang, Chaoyu, additional, Wang, Chih-Liang, additional, Wang, Jiu-Cun, additional, Wang, Junwen, additional, Wei, Fusheng, additional, Weiderpass, Elisabete, additional, Weiner, George J., additional, Weinstein, Stephanie, additional, Wentzensen, Nicolas, additional, White, Emily, additional, Witzig, Thomas E., additional, Wolpin, Brian M., additional, Wong, Maria Pik, additional, Wu, Chen, additional, Wu, Guoping, additional, Wu, Junjie, additional, Wu, Tangchun, additional, Wu, Wei, additional, Wu, Xifeng, additional, Wu, Yi-Long, additional, Wunder, Jay S., additional, Xiang, Yong-Bing, additional, Xu, Jun, additional, Xu, Ping, additional, Yang, Pan-Chyr, additional, Yang, Tsung-Ying, additional, Ye, Yuanqing, additional, Yin, Zhihua, additional, Yokota, Jun, additional, Yoon, Ho-Il, additional, Yu, Chong-Jen, additional, Yu, Herbert, additional, Yu, Kai, additional, Yuan, Jian-Min, additional, Zelenetz, Andrew, additional, Zeleniuch-Jacquotte, Anne, additional, Zhang, Xu-Chao, additional, Zhang, Yawei, additional, Zhao, Xueying, additional, Zhao, Zhenhong, additional, Zheng, Hong, additional, Zheng, Tongzhang, additional, Zheng, Wei, additional, Zhou, Baosen, additional, Zhu, Meng, additional, Zucca, Mariagrazia, additional, Boca, Simina M., additional, Cerhan, James R., additional, Ferri, Giovanni M., additional, Hartge, Patricia, additional, Hsiung, Chao Agnes, additional, Magnani, Corrado, additional, Miligi, Lucia, additional, Morton, Lindsay M., additional, Smedby, Karin E., additional, Teras, Lauren R., additional, Vijai, Joseph, additional, Wang, Sophia S., additional, Brennan, Paul, additional, Caporaso, Neil E., additional, Hunter, David J., additional, Kraft, Peter, additional, Rothman, Nathaniel, additional, Silverman, Debra T., additional, Slager, Susan L., additional, Chanock, Stephen J., additional, and Chatterjee, Nilanjan, additional
Published: 2015
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40. PRRC2A and BCL2L11 gene variants influence risk of non-Hodgkin lymphoma: results from the InterLymph consortium

Author: Nieters, Alexandra, Conde, Lucia, Slager, Susan L., Brooks-Wilson, Angela, Morton, Lindsay, Skibola, Danica R., Novak, Anne J., Riby, Jacques, Ansell, Stephen M., Halperin, Eran, Shanafelt, Tait D., Agana, Luz, Wang, Alice H., De Roos, Anneclaire J., Severson, Richard K., Cozen, Wendy, Spinelli, John, Butterbach, Katja, Becker, Nikolaus, de Sanjose, Silvia, Benavente, Yolanda, Cocco, Pierluigi, Staines, Anthony, Maynadié, Marc, Foretova, Lenka, Boffetta, Paolo, Brennan, Paul, Lan, Qing, Zhang, Yawei, Zheng, Tongzhang, Purdue, Mark, Armstrong, Bruce, Kricker, Anne, Vajdic, Claire M., Grulich, Andrew, Smith, Martyn T., Bracci, Paige M., Chanock, Stephen J., Hartge, Patricia, Cerhan, James R., Wang, Sophia S., Rothman, Nathaniel, and Skibola, Christine F.
Published: 2012
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41. Common variation at 6p21.31 (BAK1) influences the risk of chronic lymphocytic leukemia

Author: Slager, Susan L., Skibola, Christine F., Di Bernardo, Maria Chiara, Conde, Lucia, Broderick, Peter, McDonnell, Shannon K., Goldin, Lynn R., Croft, Naomi, Holroyd, Amy, Harris, Shelley, Riby, Jacques, Serie, Daniel J., Kay, Neil E., Call, Timothy G., Bracci, Paige M., Halperin, Eran, Lanasa, Mark C., Cunningham, Julie M., Leis, Jose F., Morrison, Vicki A., Spector, Logan G., Vachon, Celine M., Shanafelt, Tait D., Strom, Sara S., Camp, Nicola J., Weinberg, J. Brice, Matutes, Estella, Caporaso, Neil E., Wade, Rachel, Dyer, Martin J.S., Dearden, Claire, Cerhan, James R., Catovsky, Daniel, and Houlston, Richard S.
Published: 2012
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42. A Sandwich ELISA for Adducts of Polycyclic Aromatic Hydrocarbons with Human Serum Albumin1

Author: Chung, Ming Kei, Riby, Jacques, Li, He, Iavarone, Anthony T., Williams, Evan R., Zheng, Yuxin, and Rappaport, Stephen M.
Subjects: Pyrenes, Antibodies, Monoclonal, Enzyme-Linked Immunosorbent Assay, Air Pollutants, Occupational, DNA, Article, Mass Spectrometry, body regions, DNA Adducts, Occupational Exposure, embryonic structures, polycyclic compounds, Humans, Polycyclic Aromatic Hydrocarbons, Biomarkers, Serum Albumin
Abstract: Adducts of benzo[a]pyrene-diolepoxide (BPDE) with blood nucleophiles have been used as biomarkers of exposure to polycyclic aromatic hydrocarbons (PAHs). The most popular such assay is a competitive enzyme-linked immunosorbent assay (ELISA) that employs monoclonal antibody 8E11 to detect benzo[a]pyrene tetrols following hydrolysis of BPDE adducts from lymphocyte DNA or human serum albumin (HSA). Here we used 8E11 as the capture antibody in a sandwich ELISA to detect BPDE-HSA adducts directly in 1-mg samples of HSA or 20 microl of serum/plasma. The assay employs an anti-HSA antibody for detection, and this is amplified by an avidin/biotinylated horseradish peroxidase complex. The sandwich ELISA has advantages of specificity and simplicity and is approximately 10 times more sensitive than the competitive ELISA. To validate the assay, HSA samples were assayed from three populations with known high PAH exposures (coke oven workers), medium PAH exposures (steel factory control workers), and low PAH exposures (volunteer subjects) (n=30). The respective geometric mean levels of BPDE-HSA adducts--67.8, 14.7, and 1.93 ng/mg HSA (1010, 220, and 28.9 fmol BPDE equiv/mg HSA)--were significantly different (P0.05). The sandwich ELISA will be useful for screening PAH exposures in large epidemiologic studies and can be extended to other adducts for which capture antibodies are available.
Published: 2010

43. Abstract 5496: Mechanisms of anti-tumurogenic activity of the brown seaweed, F. vesiculosus

Author: Riby, Jacques E., primary, Conde, Lucia, additional, Cui, Xiangqin, additional, Zhang, Jianqing, additional, and Skibola, Christine F., additional
Published: 2014
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44. Copy Number Variation Analysis on a Non-Hodgkin Lymphoma Case-Control Study Identifies an 11q25 Duplication Associated with Diffuse Large B-Cell Lymphoma

Author: Conde, Lucia, primary, Riby, Jacques, additional, Zhang, Jianqing, additional, Bracci, Paige M., additional, and Skibola, Christine F., additional
Published: 2014
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45. Rare Variant Association Testing Under Low-Coverage Sequencing

Author: Navon, Oron, primary, Sul, Jae Hoon, additional, Han, Buhm, additional, Conde, Lucia, additional, Bracci, Paige M, additional, Riby, Jacques, additional, Skibola, Christine F, additional, Eskin, Eleazar, additional, and Halperin, Eran, additional
Published: 2013
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46. Abstract 2566: Functional studies of HLA SNPs associated with risk of follicular lymphoma.

Author: Skibola, Christine F., primary, Zhang, Jianqing, additional, Conde, Lucia, additional, Akers, Kipp, additional, Riby, Jacques, additional, Smith, Martyn T., additional, and Sillé, Fenna CM, additional
Published: 2013
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47. A Fucus vesiculosus extract inhibits estrogen receptor activation and induces cell death in female cancer cell lines.

Author: Jianqing Zhang, Riby, Jacques E., Lucia Conde, Grizzle, William E., Xiangqin Cui, and Skibola, Christine F.
Subjects: AUTOPHAGY, ALGAE, APOPTOSIS, BREAST tumors, CELL lines, CELLULAR signal transduction, ESTRADIOL, ESTROGEN antagonists, OVARIAN tumors, RESEARCH funding, T-test (Statistics), WESTERN immunoblotting, PLANT extracts, ENDOMETRIAL tumors, DATA analysis software, GENE expression profiling, DESCRIPTIVE statistics
Abstract: Background: We previously reported the anti-estrogenic activity of the brown seaweed, Fucus vesiculosus. The present study aimed to further investigate its anti-estrogenic modes of action and to assess other potentially biologically relevant anti-tumorigenic effects in estrogen receptor (ER)-dependent and -independent female cancer cell lines. Methods: The CALUX® assay was used to determine the effect of a F. vesiculosus extract (FVE) on activation of the ER. Aromatase enzymatic activity was measured to determine the potential effect of FVE on estradiol (E2) biosynthesis. Transcriptional activity profiling of 248 genes involved in cancer, immunity, hormonal regulation, protein phosphorylation, transcription, metabolism, and cellular structure was conducted using the NanoString nCounter® analysis system in FVE-treated breast, ovarian and endometrial cancer cell lines. The effects of FVE on cell viability, morphology, membrane integrity, mitochondrial toxicity, induction of apoptotic and autophagic markers, and cell signaling were also analyzed. Results: In co-treatments with 12.5 pM (EC50) E2, FVE (2 %) reduced ER activation by 50 %, exhibiting potent ER antagonistic effects. FVE inhibited aromatase activity in an in vitro assay (IC50 2.0 %). ER-dependent and -independent cancer cell lines showed significantly decreased viability that correlated with increasing FVE concentrations and altered morphological features suggestive of apoptosis and autophagy. Expression of genes that were significantly altered by FVE (p < 0.05) revealed predominantly apoptotic, autophagic and kinase signaling pathways. FVE also effectively inhibited the phosphorylation of Akt, resulting in reduced mTORC1 activities to stimulate autophagy in cells. Concentration-dependent cleavage of PARP and induction of caspase-3 and -7 activities were observed in MDA-MB-231 cells supporting a role for FVE in the promotion of apoptosis. Conclusions: Our study provides new insights into the anti-estrogenic activity of F. vesiculosus. Moreover, the induction of autophagy and apoptosis on breast, endometrial and ovarian cancer cell lines suggests additional anti-tumorigenic actions of FVE that are independent of ER status in female cancers. [ABSTRACT FROM AUTHOR]
Published: 2016
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48. Smoking, variation in N-acetyltransferase 1 (NAT1) and 2 (NAT2), and risk of non-Hodgkin lymphoma: a pooled analysis within the InterLymph consortium

Author: Gibson, Todd M., primary, Smedby, Karin E., additional, Skibola, Christine F., additional, Hein, David W., additional, Slager, Susan L., additional, de Sanjosé, Silvia, additional, Vajdic, Claire M., additional, Zhang, Yawei, additional, Chiu, Brian C.-H., additional, Wang, Sophia S., additional, Hjalgrim, Henrik, additional, Nieters, Alexandra, additional, Bracci, Paige M., additional, Kricker, Anne, additional, Zheng, Tongzhang, additional, Kolar, Carol, additional, Cerhan, James R., additional, Darabi, Hatef, additional, Becker, Nikolaus, additional, Conde, Lucia, additional, Holford, Theodore R., additional, Weisenburger, Dennis D., additional, De Roos, Anneclaire J., additional, Butterbach, Katja, additional, Riby, Jacques, additional, Cozen, Wendy, additional, Benavente, Yolanda, additional, Palmers, Casey, additional, Holly, Elizabeth A., additional, Sampson, Joshua N., additional, Rothman, Nathaniel, additional, Armstrong, Bruce K., additional, and Morton, Lindsay M., additional
Published: 2012
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49. Abstract 4717: A search for overlapping HLA risk loci between NHL and autoimmune diseases

Author: Conde, Lucia, primary, Bracci, Paige M., additional, Smith, Martin T., additional, Akers, Nicholas K., additional, Riby, Jacques, additional, Agana, Luz, additional, Holly, Elizabeth A., additional, Halperin, Eran, additional, and Skibola, Christine F., additional
Published: 2010
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50. Abstract B124: Genetic variants in sex hormone production, energy regulation and vitamin C and D uptake influence risk of non‐Hodgkin's lymphoma

Author: Skibola, Christine F., primary, Conde, Lucia, additional, Halperin, Eran, additional, Agana, Luz, additional, Holly, Elizabeth A., additional, Riby, Jacques, additional, Smith, Martyn T., additional, and Bracci, Paige M., additional
Published: 2010
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