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8. Sex-Related Outcomes of Transcatheter Aortic Valve Implantation With Self-Expanding or Balloon-Expandable Valves: Insights from the OPERA-TAVI Registry

Author

Adamo, Marianna, Branca, Luca, Pezzola, Elisa, Saia, Francesco, Pilgrim, Thomas, Abdel-Wahab, Mohamed, Garot, Philippe, Gandolfo, Caterina, Fiorina, Claudia, Sammartino, Sofia, Latib, Azeem, Santos, Ignacio Amat, Mylotte, Darren, De Marco, Federico, De Backer, Ole, Franco, Luis Nombela, Akodad, Mariama, Ribichini, Flavio Luciano, Bedogni, Francesco, Laterra, Giulia, Mazzapicchi, Alessandro, Tomii, Daijiro, Laforgia, Pietro, Cannata, Stefano, Scotti, Andrea, Fezzi, Simone, Criscione, Enrico, Poletti, Enrico, Mazzucca, Mattia, Valvo, Roberto, Lunardi, Mattia, Mainardi, Andrea, Andreaggi, Stefano, Quagliana, Angelo, Montarello, Nicholas, Hennessey, Breda, Mon-Noboa, Matias, Meier, David, Sgroi, Carmelo, Reddavid, Claudia Maria, Strazzieri, Orazio, Motta, Silvia Crescenzia, Frittitta, Valentina, Dipietro, Elena, Comis, Alessandro, Melfa, Chiara, Cal, Mariachiara, Thiele, Holger, Webb, John G., Søndergaard, Lars, Tamburino, Corrado, Metra, Marco, Costa, Giuliano, and Barbanti, Marco

Published
2024
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9. Evolut PRO and SAPIEN ULTRA Performance in Small Aortic Annuli: The OPERA-TAVI Registry

Author

Scotti, Andrea, Sturla, Matteo, Costa, Giuliano, Saia, Francesco, Pilgrim, Thomas, Abdel-Wahab, Mohamed, Garot, Philippe, Gandolfo, Caterina, Branca, Luca, Santos, Ignacio Amat, Mylotte, Darren, Bedogni, Francesco, De Backer, Ole, Nombela Franco, Luis, Webb, John, Ribichini, Flavio Luciano, Mainardi, Andrea, Andreaggi, Stefano, Mazzapicchi, Alessandro, Tomii, Daijiro, Laforgia, Pietro, Cannata, Stefano, Fiorina, Claudia, Fezzi, Simone, Criscione, Enrico, Lunardi, Mattia, Poletti, Enrico, Mazzucca, Mattia, Quagliana, Angelo, Montarello, Nicholas, Hennessey, Breda, Mon-Noboa, Matias, Akodad, Myriam, Meier, David, De Marco, Federico, Adamo, Marianna, Sgroi, Carmelo, Reddavid, Claudia Maria, Valvo, Roberto, Strazzieri, Orazio, Motta, Silvia Crescenzia, Frittitta, Valentina, Dipietro, Elena, Comis, Alessandro, Melfa, Chiara, Calì, Mariachiara, Sammartino, Sofia, Laterra, Giulia, Thiele, Holger, Sondergaard, Lars, Tamburino, Corrado, Barbanti, Marco, and Latib, Azeem

Published
2024
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23. LONG-TERM CLINICAL OUTCOME OF PHYSIOLOGY-GUIDED RENAL ARTERY STENTING WITH ZETAROLIMUS ELUTING STENTS IN PATIENTS WITH UNCONTROLLED RENOVASCULAR HYPERTENSION

Author

Galli, Verdiana, primary, Trento, Laura, additional, Salfa, Federica, additional, Fezzi, Simone, additional, Trevisanello, Aurora, additional, Galuppi, Enrico, additional, Casal, Matteo, additional, Piscopo, Matteo, additional, Scarsini, Roberto, additional, Pesarini, Gabriele, additional, Gambaro, Alessia, additional, Ferrero, Valeria, additional, Tavella, Domenico, additional, and Ribichini, Flavio Luciano, additional

Published
2024
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24. Management of Myocardial Revascularization in Patients With Stable Coronary Artery Disease Undergoing Transcatheter Aortic Valve Implantation

Author

Costa, Giuliano, Pilgrim, Thomas, Amat Santos, Ignacio J., De Backer, Ole, Kim, Won-Keun, Barbosa Ribeiro, Henrique, Saia, Francesco, Bunc, Matjaz, Tchetche, Didier, Garot, Philippe, Ribichini, Flavio Luciano, Mylotte, Dzxcfewarren, Burzotta, Francesco, Watanabe, Yusuke, De Marco, Federico, Tesorio, Tullio, Rheude, Tobias, Tocci, Marco, Franzone, Anna, Valvo, Roberto, Savontaus, Mikko, Wienemann, Hendrik, Porto, Italo, Gandolfo, Caterina, Iadanza, Alessandro, Bortone, Alessandro Santo, Mach, Markus, Latib, Azeem, Biasco, Luigi, Taramasso, Maurizio, Zimarino, Marco, Tomii, Daijiro, Nuyens, Philippe, Sondergaard, Lars, Camara, Sergio F., Palmerini, Tullio, Orzalkiewicz, Mateusz, Steblovnik, Klemen, Degrelle, Bastien, Gautier, Alexandre, Del Sole, Paolo Alberto, Mainardi, Andrea, Pighi, Michele, Lunardi, Mattia, Kawashima, Hideyuki, Criscione, Enrico, Cesario, Vincenzo, Biancari, Fausto, Zanin, Federico, Joner, Michael, Esposito, Giovanni, Adam, Matti, Grube, Eberhard, Baldus, Stephan, De Marzo, Vincenzo, Piredda, Elisa, Cannata, Stefano, Iacovelli, Fortunato, Andreas, Martin, Frittitta, Valentina, Dipietro, Elena, Reddavid, Claudia, Strazzieri, Orazio, Motta, Silvia, Angellotti, Domenico, Sgroi, Carmelo, Kargoli, Faraj, Tamburino, Corrado, and Barbanti, Marco

Published
2022
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30. Characterization and Management of Stable Coronary Artery Disease in Patients Undergoing Transcatheter Aortic Valve Implantation.

Author

Sammartino, Sofia, Laterra, Giulia, Pilgrim, Thomas, Amat Santos, Ignacio J., De Backer, Ole, Kim, Won-Keun, Ribeiro, Henrique Barbosa, Saia, Francesco, Bunc, Matjaz, Tchetche, Didier, Garot, Philippe, Ribichini, Flavio Luciano, Mylotte, Darren, Burzotta, Francesco, Watanabe, Yusuke, Bedogni, Francesco, Tesorio, Tullio, Rheude, Tobias, Sardella, Gennaro, and Tocci, Marco

Subjects
CORONARY artery disease, MYOCARDIAL infarction, PERCUTANEOUS coronary intervention, MYOCARDIAL revascularization, HEART valve prosthesis implantation
Abstract

Background/Objectives: To date, data regarding the characteristics and management of obstructive, stable coronary artery disease (CAD) encountered in patients undergoing transcatheter aortic valve implantation (TAVI) are sparse. The aim of the study was to analyze granular details, treatment, and outcomes of patients undergoing TAVI with obstructive, stable CAD from real-world practice. Methods: REVASC-TAVI (Management of myocardial REVASCularization in patients undergoing Transcatheter Aortic Valve Implantation with coronary artery disease) is an investigator-initiated, multicenter registry, which collected data from patients undergoing TAVI with obstructive stable CAD found during the pre-TAVI work-up. Results: A total of 2025 patients from 30 centers worldwide with complete follow-up were included in the registry. Most patients had single-vessel CAD (56.1%). An involvement of proximal coronary tracts was detected in 62.5% of cases, with 12.0% of patients having CAD in left main (LM). Most patients received percutaneous coronary intervention (PCI) (n = 1617, 79.9%), especially those with proximal CAD (90.4%). At 2 years, the rates of all-cause death [Kaplan–Meier (KM) estimates 20.1% vs. 18.8%, plog-rank = 0.86] and of the composite of all-cause death, stroke, myocardial infarction, and rehospitalization for heart failure (KM estimates 29.7% vs. 27.5%, plog-rank = 0.82) did not differ between patients undergoing PCI and those who were not. Conclusions: Patients undergoing TAVI with obstructive CAD more commonly had a single-vessel disease and an involvement of proximal coronary tracts. They were commonly treated with PCI, with similar outcomes compared to those treated conservatively. [ABSTRACT FROM AUTHOR]

Published
2024
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32. Tissue‐Tracking Mitral Annular Displacement in Neonates: A Novel Index of Left Ventricular Systolic Function.

Author

Ficial, Benjamim, Benfari, Giovanni, Bonafiglia, Elena, Clemente, Maria, Cappelleri, Alessia, Flore, Alice Iride, Petoello, Enrico, Ciarcià, Martina, Nogara, Silvia, Milocchi, Carlotta, Dani, Carlo, Ribichini, Flavio Luciano, Gottin, Leonardo, and Corsini, Iuri

Subjects
GLOBAL longitudinal strain, LEFT heart ventricle, NEWBORN infants, INTRACLASS correlation, RECEIVER operating characteristic curves, VENTRICULAR ejection fraction
Abstract

Objectives: To assess the feasibility, accuracy, and reproducibility of tissue‐tracking mitral annular displacement (TMAD) compared with other measures of left ventricular systolic function in healthy preterm and term neonates in the transitional period. Methods: This was a prospective observational study. Two echocardiograms were performed at 24 and 48 hours of life. TMAD, shortening fraction (SF), ejection fraction (EF), s′, and global longitudinal strain (GLS) were measured offline. Accuracy to detect impaired GLS was tested by ROC curve analysis. DeLong test was used to compare AUCs. Intra and interobserver reproducibility of the off‐line analysis was calculated. Results: Mean ± SD gestational age and weight were 34.2 ± 3.8 weeks and 2162 ± 833 g, respectively. TMAD was feasible in 168/180 scans (93%). At 24 hours the AUC (95% CI) of SF, EF, s′, and TMAD (%) was 0.51 (0.36–0.67), 0.68 (0.54–0.82), 0.63 (0.49–0.77), and 0.89 (0.79–0.99) respectively. At 48 hours the AUC (95% CI) of SF, EF, s′, and TMAD (%) was 0.64 (0.51–0.77), 0.59 (0.37–0.80), 0.70 (0.54–0.86), and 0.96 (0.91–1.00), respectively. The AUC of TMAD was superior to the AUC of SF, EF, s′, at both timepoints (P <.02). Intraclass correlation coefficients (95% CI) of intra and interobserver reproducibility of TMAD were 0.97 (0.95–0.99) and 0.94 (0.88–0.97), respectively. Conclusion: TMAD showed improved accuracy and optimal reproducibility in neonates in the first 48 hours of life. [ABSTRACT FROM AUTHOR]

Published
2024
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33. Tissue‐Tracking Mitral Annular Displacement in Neonates

Author

Ficial, Benjamim, primary, Benfari, Giovanni, additional, Bonafiglia, Elena, additional, Clemente, Maria, additional, Cappelleri, Alessia, additional, Flore, Alice Iride, additional, Petoello, Enrico, additional, Ciarcià, Martina, additional, Nogara, Silvia, additional, Milocchi, Carlotta, additional, Dani, Carlo, additional, Ribichini, Flavio Luciano, additional, Gottin, Leonardo, additional, and Corsini, Iuri, additional

Published
2023
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34. Right Ventricle Pulmonary Artery Coupling and Renal Function in Patients With Severe Aortic Stenosis Undergoing TAVR

Author

Fezzi, Simone, primary, Del Sole, Paolo Alberto, additional, Pighi, Michele, additional, Flaim, Massimo, additional, Mammone, Concetta, additional, Rizzetto, Francesca, additional, Tavella, Domenico, additional, Mcinerney, Angela, additional, Pesarini, Gabriele, additional, Benfari, Giovanni, additional, Scarsini, Roberto, additional, Mylotte, Darren, additional, and Ribichini, Flavio Luciano, additional

Published
2023
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35. Outpatient tricuspid regurgitation in the community: Clinical context and outcome

Author

Leonardi, Denis, primary, Bursi, Francesca, additional, Fanti, Diego, additional, Dotto, Alberto, additional, Ciceri, Luca, additional, Springhetti, Paolo, additional, Bergamini, Corinna, additional, Tafciu, Elvin, additional, Maffeis, Caterina, additional, Scarsini, Roberto, additional, Enriquez-Sarano, Maurice, additional, Ribichini, Flavio Luciano, additional, and Benfari, Giovanni, additional

Published
2023
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38. Comparison of different percutaneous revascularisation timing strategies in patients undergoing transcatheter aortic valve implantation

Author

Rheude, Tobias, primary, Costa, Giuliano, additional, Ribichini, Flavio Luciano, additional, Pilgrim, Thomas, additional, Amat Santos, Ignacio J., additional, De Backer, Ole, additional, Kim, Won‐Keun, additional, Ribeiro, Henrique Barbosa, additional, Saia, Francesco, additional, Bunc, Matjaz, additional, Tchétché, Didier, additional, Garot, Philippe, additional, Mylotte, Darren, additional, Burzotta, Francesco, additional, Watanabe, Yusuke, additional, Bedogni, Francesco, additional, Tesorio, Tullio, additional, Tocci, Marco, additional, Franzone, Anna, additional, Valvo, Roberto, additional, Savontaus, Mikko, additional, Wienemann, Hendrik, additional, Porto, Italo, additional, Gandolfo, Caterina, additional, Iadanza, Alessandro, additional, Bortone, Alessandro S., additional, Mach, Markus, additional, Latib, Azeem, additional, Biasco, Luigi, additional, Taramasso, Maurizio, additional, Zimarino, Marco, additional, Tomii, Daijiro, additional, Nuyens, Philippe, additional, Sondergaard, Lars, additional, Camara, Sergio F., additional, Palmerini, Tullio, additional, Orzalkiewicz, Mateusz, additional, Steblovnik, Klemen, additional, Degrelle, Bastien, additional, Gautier, Alexandre, additional, Del Sole, Paolo Alberto, additional, Mainardi, Andrea, additional, Pighi, Michele, additional, Lunardi, Mattia, additional, Kawashima, Hideyuki, additional, Criscione, Enrico, additional, Cesario, Vincenzo, additional, Biancari, Fausto, additional, Zanin, Federico, additional, Esposito, Giovanni, additional, Adam, Matti, additional, Grube, Eberhard, additional, Baldus, Stephan, additional, De Marzo, Vincenzo, additional, Piredda, Elisa, additional, Cannata, Stefano, additional, Iacovelli, Fortunato, additional, Andreas, Martin, additional, Frittitta, Valentina, additional, Dipietro, Elena, additional, Reddavid, Claudia, additional, Strazzieri, Orazio, additional, Motta, Silvia, additional, Angellotti, Domenico, additional, Sgroi, Carmelo, additional, Xhepa, Erion, additional, Kargoli, Faraj, additional, Tamburino, Corrado, additional, Joner, Michael, additional, and Barbanti, Marco, additional

Published
2023
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40. Role of arrhythmic phenotype in prognostic stratification and management of dilated cardiomyopathy.

Author

Setti, Martina, Merlo, Marco, Gigli, Marta, Munaretto, Laura, Paldino, Alessia, Stolfo, Davide, Pio Loco, Carola, Medo, Kristen, Gregorio, Caterina, De Luca, Antonio, Graw, Sharon, Castrichini, Matteo, Cannatà, Antonio, Ribichini, Flavio Luciano, Dal Ferro, Matteo, Taylor, Matthew, Sinagra, Gianfranco, and Mestroni, Luisa

Subjects
DILATED cardiomyopathy, PHENOTYPES, VENTRICULAR arrhythmia, VENTRICULAR tachycardia, GENETIC variation
Abstract

Aims: Dilated cardiomyopathy (DCM) with arrhythmic phenotype combines phenotypical aspects of DCM and predisposition to ventricular arrhythmias, typical of arrhythmogenic cardiomyopathy. The definition of DCM with arrhythmic phenotype is not universally accepted, leading to uncertainty in the identification of high‐risk patients. This study aimed to assess the prognostic impact of arrhythmic phenotype in risk stratification and the correlation of arrhythmic markers with high‐risk arrhythmogenic gene variants in DCM patients. Methods and results: In this multicentre study, DCM patients with available genetic testing were analysed. The following arrhythmic markers, present at baseline or within 1 year of enrolment, were tested: unexplained syncope, rapid non‐sustained ventricular tachycardia (NSVT), ≥1000 premature ventricular contractions/24 h or ≥50 ventricular couplets/24 h. LMNA, FLNC, RBM20, and desmosomal pathogenic or likely pathogenic gene variants were considered high‐risk arrhythmogenic genes. The study endpoint was a composite of sudden cardiac death and major ventricular arrhythmias (SCD/MVA). We studied 742 DCM patients (45 ± 14 years, 34% female, 410 [55%] with left ventricular ejection fraction [LVEF] <35%). During a median follow‐up of 6 years (interquartile range 1.6–12.1), unexplained syncope and NSVT were the only arrhythmic markers associated with SCD/MVA, and the combination of the two markers carried a significant additive risk of SCD/MVA, incremental to LVEF and New York Heart Association class. The probability of identifying an arrhythmogenic genotype rose from 8% to 30% if both early syncope and NSVT were present. Conclusion: In DCM patients, the combination of early detected NSVT and unexplained syncope increases the risk of life‐threatening arrhythmic outcomes and can aid the identification of carriers of malignant arrhythmogenic genotypes. [ABSTRACT FROM AUTHOR]

Published
2024
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44. Correlation between epicardial adipose tissue and atrial fibrillation burden in coronary artery bypass graft surgery

Author

Bolzan, Bruna, primary, Morani, Giovanni, additional, Rizzati, Vanni, additional, Zamboni, Mauro, additional, Mazzali, Gloria, additional, Franzese, Ilaria, additional, Tomasi, Luca, additional, Mugnai, Giacomo, additional, De Manna, Davide, additional, Benfari, Giovanni, additional, De Caro, Annamaria, additional, Cortinovis, Matteo, additional, Faggian, Giuseppe, additional, Luciani, Giovanni Battista, additional, and Ribichini, Flavio Luciano, additional

Published
2023
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45. Italian Society of Interventional Cardiology (GISE) and Italian Society of Arterial Hypertension (SIIA) Consensus document on the role of renal denervation in the management of the difficult to treat hypertension [Documento di consenso della Società Italiana di Cardiologia Interventistica (GISE) e della Società Italiana dell’Ipertensione arteriosa (SIIA) sul ruolo della denervazione renale nella gestione dell’ipertensione arteriosa difficile da trattare]

Author

Stabile, E, Muiesan, M, Ribichini, F, Sangiorgi, G, Taddei, S, Versaci, F, Villari, B, Bacca, A, Benedetto, D, Fioretti, V, Liccardo, G, Laurenzano, E, Scappaticci, M, Saia, F, Tarantini, G, Grassi, G, Esposito, G, Stabile, Eugenio, Muiesan, Maria Lorenza, Ribichini, Flavio Luciano, Sangiorgi, Giuseppe, Taddei, Stefano, Versaci, Francesco, Villari, Bruno, Bacca, Alessandra, Benedetto, Daniela, Fioretti, Vincenzo, Liccardo, Gaetano, Laurenzano, Eugenio, Scappaticci, Massimiliano, Saia, Francesco, Tarantini, Giuseppe, Grassi, Guido, Esposito, Giovanni, Stabile, E, Muiesan, M, Ribichini, F, Sangiorgi, G, Taddei, S, Versaci, F, Villari, B, Bacca, A, Benedetto, D, Fioretti, V, Liccardo, G, Laurenzano, E, Scappaticci, M, Saia, F, Tarantini, G, Grassi, G, Esposito, G, Stabile, Eugenio, Muiesan, Maria Lorenza, Ribichini, Flavio Luciano, Sangiorgi, Giuseppe, Taddei, Stefano, Versaci, Francesco, Villari, Bruno, Bacca, Alessandra, Benedetto, Daniela, Fioretti, Vincenzo, Liccardo, Gaetano, Laurenzano, Eugenio, Scappaticci, Massimiliano, Saia, Francesco, Tarantini, Giuseppe, Grassi, Guido, and Esposito, Giovanni

Abstract

Arterial hypertension is the most prevalent cardiovascular risk factor worldwide. Despite the availability of many and effective antihypertensive medications, the prevalence of uncontrolled blood pressure (BP) remains high. As sympathetic hyperactivity has long been recognized as a major contributor to resistant hypertension, catheter-based renal denervation (RDN) has emerged as a new strategy to reduce BP. RDN aims to interrupt the activity of renal sympathetic nerves by applying radiofrequency (RF) energy, ultrasound (US) energy, or injection of alcohol in the perivascular space. The Symplicity HTN-3 trial, the largest sham-controlled trial using the first-generation RF-based RDN device, failed to significantly reduce BP. Since then, new devices and techniques have been developed and consequently many sham-controlled trials using second-generation RF or US-based RDN devices have demonstrated the BP lowering efficacy and safety of the procedure. A multidisciplinary team involving hypertension experts, interventionalists with expertise in renal interventions and anesthesiologists, plays a pivotal role from the selection of the patient candidate for the procedure to the post-procedural care. The aim of this consensus document is to summarize the current evidence about the use of RDN in difficult to treat hypertension and to propose a management strategy from the selection of the patient candidate for the procedure to the post-procedural care.

Published
2023

46. Comparison of different percutaneous revascularisation timing strategies in patients undergoing transcatheter aortic valve implantation

Author

Rheude, Tobia, Costa, Giuliano, Ribichini, Flavio Luciano, Pilgrim, Thoma, Amat Santos, Ignacio J, De Backer, Ole, Kim, Won-Keun, Ribeiro, Henrique Barbosa, Saia, Francesco, Bunc, Matjaz, Tchetche, Didier, Garot, Philippe, Mylotte, Darren, Burzotta, Francesco, Watanabe, Yusuke, Bedogni, Francesco, Tesorio, Tullio, Tocci, Marco, Franzone, Anna, Valvo, Roberto, Savontaus, Mikko, Wienemann, Hendrik, Porto, Italo, Gandolfo, Caterina, Iadanza, Alessandro, Bortone, Alessandro S, Mach, Marku, Latib, Azeem, Biasco, Luigi, Taramasso, Maurizio, Zimarino, Marco, Tomii, Daijiro, Nuyens, Philippe, Sondergaard, Lar, Camara, Sergio F, Palmerini, Tullio, Orzalkiewicz, Mateusz, Steblovnik, Klemen, Degrelle, Bastien, Gautier, Alexandre, Del Sole, Paolo Alberto, Mainardi, Andrea, Pighi, Michele, Lunardi, Mattia, Kawashima, Hideyuki, Criscione, Enrico, Cesario, Vincenzo, Biancari, Fausto, Zanin, Federico, Esposito, Giovanni, Adam, Matti, Grube, Eberhard, Baldus, Stephan, De Marzo, Vincenzo, Piredda, Elisa, Cannata, Stefano, Iacovelli, Fortunato, Andreas, Martin, Frittitta, Valentina, Dipietro, Elena, Reddavid, Claudia, Strazzieri, Orazio, Motta, Silvia, Angellotti, Domenico, Sgroi, Carmelo, Xhepa, Erion, Kargoli, Faraj, Tamburino, Corrado, Joner, Michael, Barbanti, Marco, Burzotta, Francesco (ORCID:0000-0002-6569-9401), Porto, Italo (ORCID:0000-0002-9854-5046), Rheude, Tobia, Costa, Giuliano, Ribichini, Flavio Luciano, Pilgrim, Thoma, Amat Santos, Ignacio J, De Backer, Ole, Kim, Won-Keun, Ribeiro, Henrique Barbosa, Saia, Francesco, Bunc, Matjaz, Tchetche, Didier, Garot, Philippe, Mylotte, Darren, Burzotta, Francesco, Watanabe, Yusuke, Bedogni, Francesco, Tesorio, Tullio, Tocci, Marco, Franzone, Anna, Valvo, Roberto, Savontaus, Mikko, Wienemann, Hendrik, Porto, Italo, Gandolfo, Caterina, Iadanza, Alessandro, Bortone, Alessandro S, Mach, Marku, Latib, Azeem, Biasco, Luigi, Taramasso, Maurizio, Zimarino, Marco, Tomii, Daijiro, Nuyens, Philippe, Sondergaard, Lar, Camara, Sergio F, Palmerini, Tullio, Orzalkiewicz, Mateusz, Steblovnik, Klemen, Degrelle, Bastien, Gautier, Alexandre, Del Sole, Paolo Alberto, Mainardi, Andrea, Pighi, Michele, Lunardi, Mattia, Kawashima, Hideyuki, Criscione, Enrico, Cesario, Vincenzo, Biancari, Fausto, Zanin, Federico, Esposito, Giovanni, Adam, Matti, Grube, Eberhard, Baldus, Stephan, De Marzo, Vincenzo, Piredda, Elisa, Cannata, Stefano, Iacovelli, Fortunato, Andreas, Martin, Frittitta, Valentina, Dipietro, Elena, Reddavid, Claudia, Strazzieri, Orazio, Motta, Silvia, Angellotti, Domenico, Sgroi, Carmelo, Xhepa, Erion, Kargoli, Faraj, Tamburino, Corrado, Joner, Michael, Barbanti, Marco, Burzotta, Francesco (ORCID:0000-0002-6569-9401), and Porto, Italo (ORCID:0000-0002-9854-5046)

Abstract

Background: The optimal timing to perform percutaneous coronary interventions (PCI) in transcatheter aortic valve implantation (TAVI) patients remains unknown. Aims: We sought to compare different PCI timing strategies in TAVI patients. Methods: The REVASC-TAVI registry is an international registry including patients undergoing TAVI with significant, stable coronary artery disease (CAD) at preprocedural workup. In this analysis, patients scheduled to undergo PCI before, after or concomitantly with TAVI were included. The main endpoints were all-cause death and a composite of all-cause death, stroke, myocardial infarction (MI) or rehospitalisation for congestive heart failure (CHF) at 2 years. Outcomes were adjusted using the inverse probability treatment weighting (IPTW) method. Results: A total of 1,603 patients were included. PCI was performed before, after or concomitantly with TAVI in 65.6% (n=1,052), 9.8% (n=157) or 24.6% (n=394), respectively. At 2 years, all-cause death was significantly lower in patients undergoing PCI after TAVI as compared with PCI before or concomitantly with TAVI (6.8% vs 20.1% vs 20.6%; p<0.001). Likewise, the composite endpoint was significantly lower in patients undergoing PCI after TAVI as compared with PCI before or concomitantly with TAVI (17.4% vs 30.4% vs 30.0%; p=0.003). Results were confirmed at landmark analyses considering events from 0 to 30 days and from 31 to 720 days. Conclusions: In patients with severe aortic stenosis and stable coronary artery disease scheduled for TAVI, performance of PCI after TAVI seems to be associated with improved 2-year clinical outcomes compared with other revascularisation timing strategies. These results need to be confirmed in randomised clinical trials.

Published
2023

47. Comparison of different percutaneous revascularisation timing strategies in patients undergoing transcatheter aortic valve implantation

Author

Rheude, Tobias, Costa, Giuliano, Ribichini, Flavio Luciano, Pilgrim, Thomas, Amat-Santos, Ignacio J., De Backer, Ole, Kim, Won Keun, Ribeiro, Henrique Barbosa, Saia, Francesco, Bunc, Matjaz, Tchétché, Didier, Garot, Philippe, Mylotte, Darren, Burzotta, Francesco, Watanabe, Yusuke, Bedogni, Francesco, Tesorio, Tullio, Tocci, Marco, Franzone, Anna, Valvo, Roberto, Savontaus, Mikko, Wienemann, Hendrik, Porto, Italo, Gandolfo, Caterina, Iadanza, Alessandro, Bortone, Alessandro S., Mach, Markus, Latib, Azeem, Biasco, Luigi, Taramasso, Maurizio, Zimarino, Marco, Tomii, Daijiro, Nuyens, Philippe, Sondergaard, Lars, Camara, Sergio F., Palmerini, Tullio, Orzalkiewicz, Mateusz, Steblovnik, Klemen, Degrelle, Bastien, Gautier, Alexandre, Del Sole, Paolo Alberto, Mainardi, Andrea, Pighi, Michele, Lunardi, Mattia, Kawashima, Hideyuki, Criscione, Enrico, Cesario, Vincenzo, Biancari, Fausto, Zanin, Federico, Esposito, Giovanni, Adam, Matti, Grube, Eberhard, Baldus, Stephan, De Marzo, Vincenzo, Piredda, Elisa, Cannata, Stefano, Iacovelli, Fortunato, Andreas, Martin, Frittitta, Valentina, Dipietro, Elena, Reddavid, Claudia, Strazzieri, Orazio, Motta, Silvia, Angellotti, Domenico, Sgroi, Carmelo, Xhepa, Erion, Kargoli, Faraj, Tamburino, Corrado, Joner, Michael, Barbanti, Marco, Rheude, Tobias, Costa, Giuliano, Ribichini, Flavio Luciano, Pilgrim, Thomas, Amat-Santos, Ignacio J., De Backer, Ole, Kim, Won Keun, Ribeiro, Henrique Barbosa, Saia, Francesco, Bunc, Matjaz, Tchétché, Didier, Garot, Philippe, Mylotte, Darren, Burzotta, Francesco, Watanabe, Yusuke, Bedogni, Francesco, Tesorio, Tullio, Tocci, Marco, Franzone, Anna, Valvo, Roberto, Savontaus, Mikko, Wienemann, Hendrik, Porto, Italo, Gandolfo, Caterina, Iadanza, Alessandro, Bortone, Alessandro S., Mach, Markus, Latib, Azeem, Biasco, Luigi, Taramasso, Maurizio, Zimarino, Marco, Tomii, Daijiro, Nuyens, Philippe, Sondergaard, Lars, Camara, Sergio F., Palmerini, Tullio, Orzalkiewicz, Mateusz, Steblovnik, Klemen, Degrelle, Bastien, Gautier, Alexandre, Del Sole, Paolo Alberto, Mainardi, Andrea, Pighi, Michele, Lunardi, Mattia, Kawashima, Hideyuki, Criscione, Enrico, Cesario, Vincenzo, Biancari, Fausto, Zanin, Federico, Esposito, Giovanni, Adam, Matti, Grube, Eberhard, Baldus, Stephan, De Marzo, Vincenzo, Piredda, Elisa, Cannata, Stefano, Iacovelli, Fortunato, Andreas, Martin, Frittitta, Valentina, Dipietro, Elena, Reddavid, Claudia, Strazzieri, Orazio, Motta, Silvia, Angellotti, Domenico, Sgroi, Carmelo, Xhepa, Erion, Kargoli, Faraj, Tamburino, Corrado, Joner, Michael, and Barbanti, Marco

Abstract

Background: The optimal timing to perform percutaneous coronary interventions (PCI) in transcatheter aortic valve implantation (TAVI) patients remains unknown. Aims: We sought to compare different PCI timing strategies in TAVI patients. Methods: The REVASC-TAVI registry is an international registry including patients undergoing TAVI with significant, stable coronary artery disease (CAD) at preprocedural workup. In this analysis, patients scheduled to undergo PCI before, after or concomitantly with TAVI were included. The main endpoints were all-cause death and a composite of all-cause death, stroke, myocardial infarction (MI) or rehospitalisation for congestive heart failure (CHF) at 2 years. Outcomes were adjusted using the inverse probability treatment weighting (IPTW) method. Results: A total of 1,603 patients were included. PCI was performed before, after or concomitantly with TAVI in 65.6% (n=1,052), 9.8% (n=157) or 24.6% (n=394), respectively. At 2 years, all-cause death was significantly lower in patients undergoing PCI after TAVI as compared with PCI before or concomitantly with TAVI (6.8% vs 20.1% vs 20.6%; p<0.001). Likewise, the composite endpoint was significantly lower in patients undergoing PCI after TAVI as compared with PCI before or concomitantly with TAVI., Background: The optimal timing to perform percutaneous coronary interventions (PCI) in transcatheter aortic valve implantation (TAVI) patients remains unknown. Aims: We sought to compare different PCI timing strategies in TAVI patients. Methods: The REVASC-TAVI registry is an international registry including patients undergoing TAVI with significant, stable coronary artery disease (CAD) at preprocedural workup. In this analysis, patients scheduled to undergo PCI before, after or concomitantly with TAVI were included. The main endpoints were all-cause death and a composite of all-cause death, stroke, myocardial infarction (MI) or rehospitalisation for congestive heart failure (CHF) at 2 years. Outcomes were adjusted using the inverse probability treatment weighting (IPTW) method. Results: A total of 1,603 patients were included. PCI was performed before, after or concomitantly with TAVI in 65.6% (n=1,052), 9.8% (n=157) or 24.6% (n=394), respectively. At 2 years, all-cause death was significantly lower in patients undergoing PCI after TAVI as compared with PCI before or concomitantly with TAVI (6.8% vs 20.1% vs 20.6%; p<0.001). Likewise, the composite endpoint was significantly lower in patients undergoing PCI after TAVI as compared with PCI before or concomitantly with TAVI (17.4% vs 30.4% vs 30.0%; p=0.003). Results were confirmed at landmark analyses considering events from 0 to 30 days and from 31 to 720 days. Conclusions: In patients with severe aortic stenosis and stable coronary artery disease scheduled for TAVI, performance of PCI after TAVI seems to be associated with improved 2-year clinical outcomes compared with other revascularisation timing strategies. These results need to be confirmed in randomised clinical trials.

Published
2023

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