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2. Impact of the COVID-19 Pandemic on Global TAVR Activity: The COVID-TAVI Study

Author

Armario, Xavier, Carron, Jennifer, Simpkin, Andrew J., Elhadi, Mohamed, Kennedy, Ciara, Abdel-Wahab, Mohamed, Bleiziffer, Sabine, Lefèvre, Thierry, Wolf, Alexander, Pilgrim, Thomas, Villablanca, Pedro A., Blackman, Daniel J., Van Mieghem, Nicolas M., Hengstenberg, Christian, Swaans, Martin J., Prendergast, Bernard D., Patterson, Tiffany, Barbanti, Marco, Webb, John G., Behan, Miles, Resar, Jon, Chen, Mao, Hildick-Smith, David, Spence, Mark S., Zweiker, David, Bagur, Rodrigo, Teles, Rui, Ribichini, Flavio L., Jagielak, Dariusz, Park, Duk-Woo, Kornowski, Ran, Wykrzykowska, Joanna J., Bunc, Matjaz, Estévez-Loureiro, Rodrigo, Poon, Karl, Götberg, Matthias, Jeger, Raban V., Ince, Hüseyin, Packer, Erik J.S., Angelillis, Marco, Nombela-Franco, Luis, Guo, Yingqiang, Savontaus, Mikko, Al-Moghairi, Abdulrahman M., Parasca, Catalina Andreea, Kliger, Chad, Roy, David, Molnár, Levente, Silva, Mariana, White, Jonathon, Yamamoto, Masanori, Carrilho-Ferreira, Pedro, Toggweiler, Stefan, Voudris, Vassileios, Ohno, Yohei, Rodrigues, Inês, Parma, Radosław, Ojeda, Soledad, Toutouzas, Kostas, Regueiro, Ander, Grygier, Marek, AlMerri, Khaled, Cruz-González, Ignacio, Fridrich, Viliam, de la Torre Hernández, José M., Noble, Stephane, Kala, Petr, Asmarats, Lluis, Kurt, Ibrahim Halil, Bosmans, Johan, Erglis, Martins, Casserly, Ivan, Iskandarani, Dounia, Bhindi, Ravinay, Kefer, Joelle, Yin, Wei-Hsian, Rosseel, Liesbeth, Kim, Hyo-Soo, O'Connor, Stephen, Hellig, Farrel, Sztejfman, Matias, Mendiz, Oscar, Pineda, Andres M., Seth, Ashok, Pllaha, Elton, de Brito, Fabio S., Jr., Bajoras, Vilhelmas, Balghith, Mohammed A., Lee, Michael, Eid-Lidt, Guering, Vandeloo, Bert, Vaz, Vinicius Daher, Alasnag, Mirvat, Ussia, Gian Paolo, Tay, Edgar, Mayol, Jorge, Gunasekaran, Sengottuvelu, Sardella, Gennaro, Buddhari, Wacin, Kao, Hsien-Li, Dager, Antonio, Tzikas, Apostolos, Gudmundsdottir, Ingibjörg J., Edris, Ahmad, Gutiérrez Jaikel, Luis Abel, Arias, Eduardo A., Al-Hijji, Mohammed, Ertürk, Mehmet, Conde-Vela, César, Boljević, Darko, Ferrero Guadagnoli, Adolfo, Hermlin, Toomas, ElGuindy, Ahmed M., Lima-Filho, Moysés de Oliveira, de Moura Santos, Luciano, Perez, Luis, Maluenda, Gabriel, Akyüz, Ali Rıza, Alhaddad, Imad A., Amin, Haitham, So, Chak-Yu, Al Nooryani, Arif A., Vaca, Carlos, Albistur, Juan, Nguyen, Quang Ngoc, Arzamendi, Dabit, Grube, Eberhard, Modine, Thomas, Tchétché, Didier, Hayashida, Kentaro, Latib, Azeem, Makkar, Raj R., Piazza, Nicolo, Søndergaard, Lars, McEvoy, John William, and Mylotte, Darren

Published
2024
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4. Coronary physiology assessments: historical overview and future challenges

Author

SCARSINI, Roberto, primary, ZANON, Sofia, additional, MAISENTI, Sara, additional, PAZZI, Sara, additional, BUTTURINI, Caterina, additional, RUBINO, Francesca, additional, PORTOLAN, Leonardo, additional, PRADO, Guy F., additional, FEZZI, Simone, additional, TAVELLA, Domenico, additional, PESARINI, Gabriele, additional, and RIBICHINI, Flavio L., additional

Published
2024
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5. Calcified Nodule in Percutaneous Coronary Intervention

Author

Shin, Doosup, primary, Karimi Galougahi, Keyvan, additional, Spratt, James C., additional, Maehara, Akiko, additional, Collet, Carlos, additional, Barbato, Emanuele, additional, Ribichini, Flavio L., additional, Gonzalo, Nieves, additional, Sakai, Koshiro, additional, Mintz, Gary S., additional, Stone, Gregg W., additional, Shlofmitz, Evan, additional, Shlofmitz, Richard A., additional, Jeremias, Allen, additional, and Ali, Ziad A., additional

Published
2024
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6. Italian Society of Interventional Cardiology (GISE) and Italian Society of Arterial Hypertension (SIIA) Position Paper on the role of renal denervation in the management of the difficult-to-treat hypertension.

Author

STABILE, Eugenio, MUIESAN, Maria L., RIBICHINI, Flavio L., SANGIORGI, Giuseppe, TADDEI, Stefano, VERSACI, Francesco, VILLARI, Bruno, BACCA, Alessandra, BENEDETTO, Daniela, FIORETTI, Vincenzo, LAURENZANO, Eugenio, SCAPATICCI, Massimilano, SAIA, Francesco, TARANTINI, Giuseppe, GRASSI, Guido, and ESPOSITO, Giovanni

Published
2024
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11. Severe aortic stenosis: secular trends of incidence and outcomes.

Author

Benfari, Giovanni, Essayagh, Benjamin, Michelena, Hector I, Ye, Zi, Inojosa, Jose Medina, Ribichini, Flavio L, Crestanello, Juan, Messika-Zeitoun, David, Prendergast, Bernard, Wong, Benjamin F, Thapa, Prabin, and Enriquez-Sarano, Maurice

Subjects
AORTIC stenosis, AORTIC valve transplantation, AORTIC valve, ECHOCARDIOGRAPHY
Abstract

Background and Aims: Severe aortic stenosis (AS) is the guideline-based indication for aortic valve replacement (AVR), which has markedly increased with transcatheter approaches, suggesting possible increasing AS incidence. However, reported secular trends of AS incidence remain contradictory and lack quantitative Doppler echocardiographic ascertainment. Methods: All adults residents in Olmsted County (MN, USA) diagnosed over 20 years (1997–2016) with incident severe AS (first diagnosis) based on quantitatively defined measures (aortic valve area ≤ 1 cm2, aortic valve area index ≤ 0.6 cm2/m2, mean gradient ≥ 40 mmHg, peak velocity ≥ 4 m/s, Doppler velocity index ≤ 0.25) were counted to define trends in incidence, presentation, treatment, and outcome. Results: Incident severe AS was diagnosed in 1069 community residents. The incidence rate was 52.5 [49.4–55.8] per 100 000 patient-year, slightly higher in males vs. females and was almost unchanged after age and sex adjustment for the US population 53.8 [50.6–57.0] per 100 000 residents/year. Over 20 years, severe AS incidence remained stable (P =.2) but absolute burden of incident cases markedly increased (P =.0004) due to population growth. Incidence trend differed by sex, stable in men (incidence rate ratio 0.99, P =.7) but declining in women (incidence rate ratio 0.93, P =.02). Over the study, AS clinical characteristics remained remarkably stable and AVR performance grew and was more prompt (from 1.3 [0.1–3.3] years in 1997–2000 to 0.5 [0.2–2.1] years in 2013–16, P =.001) but undertreatment remained prominent (>40%). Early AVR was associated with survival benefit (adjusted hazard ratio 0.55 [0.42–0.71], P <.0001). Despite these improvements, overall mortality (3-month 8% and 3-year 36%), was swift, considerable and unabated (all P ≥.4) throughout the study. Conclusions: Over 20 years, the population incidence of severe AS remained stable with increased absolute case burden related to population growth. Despite stable severe AS presentation, AVR performance grew notably, but while declining, undertreatment remained substantial and disease lethality did not yet decline. These population-based findings have important implications for improving AS management pathways. Structured Graphical Abstract Secular trends of incidence, management, and outcome of severe aortic valve stenosis identified by quantitative echocardiographic criteria in the Olmsted County population. AS, aortic stenosis; AVR, aortic valve replacement. [ABSTRACT FROM AUTHOR]

Published
2024
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13. Procedural and one-year outcomes of the BASILICA technique in Europe: the multicentre EURO-BASILICA registry

Author

Abdel-Wahab, Mohamed, primary, Richter, Ines, additional, Taramasso, Maurizio, additional, Unbehaun, Axel, additional, Rudolph, Tanja, additional, Ribichini, Flavio L., additional, Binder, Ronald, additional, Schofer, Joachim, additional, Mangner, Norman, additional, Dambrink, Jan-Henk, additional, Trejo-Velasco, Blanca, additional, Thiele, Holger, additional, Kitamura, Mitsunobu, additional, and Lanz, Jonas, additional

Published
2023
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16. Coronary physiology in the catheterisation laboratory: an A to Z practical guide

Author

Fezzi, Simone, Huang, Jiayue, Lunardi, Mattia, Ding, Daixin, Ribichini, Flavio L., Tu, Shengxian, and Wijns, William

Subjects
Expert Review
Abstract

Coronary revascularisation, either percutaneous or surgical, aims to improve coronary flow and relieve myocardial ischaemia. The decision-making process in patients with coronary artery disease (CAD) remains largely based on invasive coronary angiography (ICA), even though until recently ICA could not assess the functional significance of coronary artery stenoses. Invasive wire-based approaches for physiological evaluations were developed to properly assess the ischaemic relevance of epicardial CAD. Fractional flow reserve (FFR) and later, instantaneous wave-free ratio (iFR), were shown to improve clinical outcomes in several patient subsets when used for coronary revascularisation guidance or deferral and for procedural optimisation of percutaneous coronary intervention (PCI) results. Despite accumulating evidence and positive guideline recommendations, the adoption of invasive physiology has remained quite low, mainly due to technical and economic issues as well as to operator-resistance to change. Coronary image-based computational physiology has been recently developed, with promising results in terms of accuracy and a reduction in computational time, costs, radiation exposure and risks for the patient. Lastly, the integration of intracoronary imaging and physiology allows for individualised PCI treatment, aiming at complete relief of ischaemia through optimised morpho-functional immediate procedural results. Instead of a conventional state-of-the-art review, this A to Z dictionary attempts to provide a practical guide for the application of coronary physiology in the catheterisation laboratory, exploring several methods, their pitfalls, and useful tips and tricks.

Published
2022

18. Quantitative coronary three‐dimensional geometry and its association with atherosclerotic disease burden and composition

Author

A. Prado, Guy F., primary, Blanco, Pablo J., additional, Bulant, Carlos A., additional, Ares, Gonzalo D., additional, Mariani, Jose, additional, Caixeta, Adriano, additional, Almeida, Breno O., additional, Garzon, Stefano, additional, Pinton, Fábio A., additional, Barbato, Emanuele, additional, Ribichini, Flavio L., additional, Toth, Gabor G., additional, Mahfoud, Felix, additional, Wijns, William, additional, Garcia‐Garcia, Hector M., additional, and Lemos, Pedro A., additional

Published
2023
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19. One-year outcomes after transcatheter aortic valve implantation with the latest-generation SAPIEN balloon-expandable valve: the S3U registry

Author

Cannata, Stefano, primary, Gandolfo, Caterina, additional, Ribichini, Flavio L., additional, van Mieghem, Nicolas, additional, Buccheri, Sergio, additional, Barbanti, Marco, additional, Berti, Sergio, additional, Teles, Rui Campante, additional, Bartorelli, Antonio L., additional, Musumeci, Giuseppe, additional, Piva, Tommaso, additional, Nombela-Franco, Luis, additional, La Spina, Ketty, additional, Palmerini, Tullio, additional, Adrichem, Rik, additional, Esposito, Augusto, additional, Lopes, Pedro, additional, Olivares, Paolo, additional, Annibali, Gianmarco, additional, Nicolini, Elisa, additional, Marroquin, Luis, additional, Tamburino, Corrado, additional, Tarantini, Giuseppe, additional, and Saia, Francesco, additional

Published
2023
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20. The usefulness of QRS Index for prediction of echocardiographic response in cardiac resynchronization therapy: a multicenter study

Author

MUGNAI, Giacomo, primary, DONAZZAN, Luca, additional, TOMASI, Luca, additional, PICCOLI, Anna, additional, CAVEDON, Stefano, additional, PESCOLLER, Felix, additional, BOLZAN, Bruna, additional, PERRONE, Cosimo, additional, RAUHE, Werner G., additional, OBERHOLLENZER, Rainer, additional, BILATO, Claudio, additional, and RIBICHINI, Flavio L., additional

Published
2023
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21. Renal denervation in the management of hypertension in adults. A clinical consensus statement of the ESC Council on Hypertension and the European Association of Percutaneous Cardiovascular Interventions (EAPCI)

Author

Barbato, Emanuele, primary, Azizi, Michel, additional, Schmieder, Roland E, additional, Lauder, Lucas, additional, Böhm, Michael, additional, Brouwers, Sofie, additional, Bruno, Rosa Maria, additional, Dudek, Dariusz, additional, Kahan, Thomas, additional, Kandzari, David E, additional, Lüscher, Thomas F, additional, Parati, Gianfranco, additional, Pathak, Atul, additional, Ribichini, Flavio L, additional, Schlaich, Markus P, additional, Sharp, Andrew S P, additional, Sudano, Isabella, additional, Volpe, Massimo, additional, Tsioufis, Costas, additional, Wijns, William, additional, and Mahfoud, Felix, additional

Published
2023
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22. A large, prospective, multicentre study of left main PCI using a latest-generation zotarolimus-eluting stent: the ROLEX study

Author

Tarantini, Giuseppe, primary, Fovino, Luca Nai, additional, Varbella, Ferdinando, additional, Trabattoni, Daniela, additional, Caramanno, Giuseppe, additional, Trani, Carlo, additional, De Cesare, Nicoletta, additional, Esposito, Giovanni, additional, Montorfano, Matteo, additional, Musto, Carmine, additional, Picchi, Andrea, additional, Sheiban, Imad, additional, Gasparetto, Valeria, additional, Ribichini, Flavio L., additional, Cardaioli, Francesco, additional, Saccà, Salvatore, additional, Cerrato, Enrico, additional, Napodano, Massimo, additional, Martinato, Matteo, additional, Azzolina, Danila, additional, Andò, Giuseppe, additional, Mugnolo, Antonio, additional, Caruso, Marco, additional, Rossini, Roberta, additional, Passamonti, Enrico, additional, Teles, Rui Campante, additional, Rigattieri, Stefano, additional, Gregori, Dario, additional, Tamburino, Corrado, additional, and Burzotta, Francesco, additional

Published
2023
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26. Predicted clinical and economic burden associated with reduction in access to acute coronary interventional care during the COVID-19 lockdown in two European countries

Author

Lunardi, Mattia, Mamas, Mamas A, Mauri, Josepa, Molina, Carmen Medina, Rodriguez-Leor, Oriol, Eggington, Simon, Pietzsch, Jan B, Papo, Natalie L, Walleser-Autiero, Silke, Baumbach, Andreas, Maisano, Francesco, Ribichini, Flavio L, Mylotte, Darren, Barbato, Emanuele, Piek, Jan J, Wijns, William, and Naber, Christoph K

Abstract

Graphical AbstractLockdown leads to suboptimal treatment which translates into poor outcomes and increased societal costs.

Published
2024
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29. Functional Patterns of Coronary Disease

Author

Scarsini, Roberto, primary, Fezzi, Simone, additional, Leone, Antonio Maria, additional, De Maria, Giovanni Luigi, additional, Pighi, Michele, additional, Marcoli, Michele, additional, Tavella, Domenico, additional, Pesarini, Gabriele, additional, Banning, Adrian P., additional, Barbato, Emanuele, additional, Wijns, William, additional, and Ribichini, Flavio L., additional

Published
2022
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31. A large, prospective, multicentre study of left main PCI using a latest-generation zotarolimus-eluting stent: the ROLEX study

Author

Tarantini, Giuseppe, Fovino, Luca Nai, Varbella, Ferdinando, Trabattoni, Daniela, Caramanno, Giuseppe, Trani, Carlo, De Cesare, Nicoletta, Esposito, Giovanni, Montorfano, Matteo, Musto, Carmine, Picchi, Andrea, Sheiban, Imad, Gasparetto, Valeria, Ribichini, Flavio L, Cardaioli, Francesco, Saccà, Salvatore, Cerrato, Enrico, Napodano, Massimo, Martinato, Matteo, Azzolina, Danila, Andò, Giuseppe, Mugnolo, Antonio, Caruso, Marco, Rossini, Roberta, Passamonti, Enrico, Teles, Rui Campante, Rigattieri, Stefano, Gregori, Dario, Tamburino, Corrado, and Burzotta, Francesco

Subjects
cardiovascular disease, Settore MED/11 - MALATTIE DELL'APPARATO CARDIOVASCOLARE, pci, stent, heart disease, Cardiology and Cardiovascular Medicine
Abstract

Data on left main (LM) percutaneous coronary interventions (PCI) have mostly been obtained in studies using drug-eluting stent (DES) platforms without dedicated large-vessel devices and with limited expansion capability.Our study aimed to investigate the safety and efficacy of LM PCI with the latest-generation Resolute Onyx DES.ROLEX (Revascularization Of LEft main with resolute onyX) is a prospective, multicentre study (ClinicalTrials.gov: NCT03316833) enrolling patients with unprotected LM coronary artery disease and a SYNTAX score33 undergoing PCI with the Resolute Onyx zotarolimus-eluting coronary stent, that includes dedicated extra-large vessel platforms. The primary endpoint (EP) was target lesion failure (TLF): a composite of cardiac death, target vessel myocardial infarction (TVMI) and ischaemia-driven target lesion revascularisation (ID-TLR), at 1 year. All events were adjudicated by an independent clinical event committee. An independent core lab analysed all procedural angiograms.A total of 450 patients (mean age 71.8 years, SYNTAX score 24.5±7.2, acute coronary syndrome in 53%) were enrolled in 26 centres. Of these, 77% of subjects underwent PCI with a single-stent and 23% with a 2-stent technique (8% double kissing [DK] crush, 6% culotte, 9% T/T and small protrusion [TAP] stenting). Intravascular imaging guidance was used in 45% (42% intravascular ultrasound [IVUS], 3% optical coherence tomography [OCT]). At 1 year, the primary EP incidence was 5.1% (cardiac death 2.7%, TVMI 2.7%, ID-TLR 2.0%). The definite/probable stent thrombosis rate was 1.1%. In a prespecified adjusted subanalysis, the primary EP incidence was significantly lower in patients undergoing IVUS/OCT-guided versus angio-guided PCI (2.0 vs 7.6%; hazard ratio [HR] 0.28, 95% confidence interval [CI]: 0.13-0.58; p0.001).In this large, multicentre, prospective registry, LM PCI with the Resolute Onyx DES showed good safety and efficacy at 1 year, particularly when guided by intracoronary imaging.

Published
2022

36. Determinants of exercise intolerance symptoms considered non-specific for heart failure in patients with stage A and B: role of the left atrium in the transition phase to overt heart failure

Author

Maffeis, Caterina, primary, Inciardi, Riccardo M., additional, Khan, Muhammad Shahzeb, additional, Tafciu, Elvin, additional, Bergamini, Corinna, additional, Benfari, Giovanni, additional, Setti, Martina, additional, Ribichini, Flavio L., additional, Cicoira, Mariantonietta, additional, Butler, Javed, additional, and Rossi, Andrea, additional

Published
2021
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37. Pressure-bounded coronary flow reserve to assess the extent of microvascular dysfunction in patients with ST-elevation acute myocardial infarction: Pressure-bounded coronary flow reserve in STEMI

Author

Scarsini, Roberto, De Maria, Giovanni Luigi, Shanmuganathan, Mayooran, Kotronias, Rafail, Terentes-Printzios, Dimitrios, Langrish, Jeremy, Lucking, Andrew, Ribichini, Flavio L., Choudhury, Robin, Kharbanda, Rajesh K. K., Ferreira, Vanessa, Channon, Keith, and Banning, Adrian P.

Subjects
Percutaneous Coronary Intervention, Clinical Research, Coronary Circulation, Microcirculation, Humans, ST Elevation Myocardial Infarction, Vascular Resistance
Abstract

AIMS: Assessment of microvascular function in patients with ST-elevation acute myocardial infarction (STEMI) may be useful to determine treatment strategy. The possible role of pressure-bounded coronary flow reserve (pb-CFR) in this setting has not been determined. In this study we aimed to compare pb-CFR with thermodilution-derived physiology including the index of microcirculatory resistance (IMR) and CFR(thermo) in a consecutive series of patients enrolled in the OxAMI study. Moreover, we aimed to assess the presence of microvascular obstruction (MVO) and myocardial injury on cardiovascular magnetic resonance (CMR) imaging performed at 48 hours and six months in STEMI patients stratified according to pb-CFR. METHODS AND RESULTS: Thermodilution-pressure-wire assessment of the infarct-related artery was performed in 148 STEMI patients before stenting and/or at completion of primary percutaneous coronary intervention (PPCI). The extent of the myocardial injury was assessed with CMR imaging at 48 hours and six months after STEMI. Post-PPCI pb-CFR was impaired (2) in 69.9% and 9.0% of the cases, respectively. In the remaining 21.1% of the patients, pb-CFR was “indeterminate”. In this cohort, pb-CFR correlated poorly with thermodilution-derived coronary flow reserve (k=0.03, p=0.39). The IMR was significantly different across the pb-CFR subgroups. Similarly, significant differences were observed in MVO, myocardium area at risk and 48-hour infarct size (IS). A trend towards lower six-month IS was observed in patients with high (>2) post-PPCI pb-CFR. Nevertheless, pb-CFR was inferior to IMR in predicting MVO and the extent of IS. CONCLUSIONS: Pb-CFR can identify microvascular dysfunction in patients after STEMI. It provided superior diagnostic performance compared to thermodilution-derived CFR in predicting MVO. However, IMR was superior to both pb-CFR and thermodilution-derived CFR and, consequently, IMR was the most accurate in predicting all of the studied CMR endpoints of myocardial injury after PPCI.

Published
2021

38. Real-time use of instantaneous wave–free ratio: Results of the ADVISE in-practice: An international, multicenter evaluation of instantaneous wave–free ratio in clinical practice

Author

Petraco, Ricardo, Al-Lamee, Rasha, Gotberg, Matthias, Sharp, Andrew, Hellig, Farrel, Nijjer, Sukhjinder S., Echavarria-Pinto, Mauro, van de Hoef, Tim P., Sen, Sayan, Tanaka, Nobuhiro, Van Belle, Eric, Bojara, Waldemar, Sakoda, Kunihiro, Mates, Martin, Indolfi, Ciro, De Rosa, Salvatore, Vrints, Christian J., Haine, Steven, Yokoi, Hiroyoshi, Ribichini, Flavio L., Meuwissen, Martjin, Matsuo, Hitoshi, Janssens, Luc, Katsumi, Ueno, Di Mario, Carlo, Escaned, Javier, Piek, Jan, and Davies, Justin E.

Published
2014
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39. Changes in surgical revascularization strategy after fractional flow reserve

Author

Fournier, Stephane, primary, Toth, Gabor G, additional, De Bruyne, Bernard, additional, Kala, Petr, additional, Ribichini, Flavio L, additional, Casselman, Filip, additional, Ramos, Ruben, additional, Piroth, Zsolt, additional, Piccoli, Anna, additional, Penicka, Martin, additional, Mates, Martin, additional, Nemec, Petr, additional, Van Praet, Frank, additional, Stockman, Bernard, additional, Degriek, Ivan, additional, Pellicano, Mariano, additional, and Barbato, Emanuele, additional

Published
2021
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40. Pressure-bounded coronary flow reserve to assess the extent of microvascular dysfunction in patients with ST-elevation acute myocardial infarction

Author

Scarsini, Roberto, primary, De Maria, Giovanni Luigi, additional, Shanmuganathan, Mayooran, additional, Kotronias, Rafail A., additional, Terentes-Printzios, Dimitrios, additional, Langrish, Jeremy, additional, Lucking, Andrew J., additional, Ribichini, Flavio L., additional, Choudhury, Robin, additional, Kharbanda, Rajesh K., additional, Ferreira, Vanessa, additional, Channon, Keith M., additional, and Banning, Adrian P., additional

Published
2021
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43. The right parasternal window : when Doppler-beam alignment may be life-saving in patients with aortic valve stenosis

Author

Giovanni, Benfari, Mantovani, Francesca, Romero-Brufau, Santiago, Setti, Martina, Rossi, Andrea, Ribichini, Flavio L., Nistri, Stefano, Clavel, Marie-Annick, Giovanni, Benfari, Mantovani, Francesca, Romero-Brufau, Santiago, Setti, Martina, Rossi, Andrea, Ribichini, Flavio L., Nistri, Stefano, and Clavel, Marie-Annick

Abstract

The need for multiple transducer positions, especially from right parasternal windows, is consistently mentioned in the recommendations for the accurate measurement of peak velocities across a stenotic aortic valve, but yet poorly adopted. We performed a subanalysis of the largest prospective series on the right parasternal acoustic windows in patients with aortic stenosis (330 consecutive) to calculate the degree of misalignment and estimate the potential outcome implication of this often-forgotten approach. The right parasternal view was highly feasible with an average estimated misalignment from the apical view of 14 ± 16 degree; in 10 cases, an estimated misalignment >40 degree. Right parasternal assessment (vs. apical alone) provided a significant reclassification from moderate to severe or even very-severe aortic valve stenosis. Considering a wellestablished survival benefit provided by either percutaneous or surgical valve replacement in patients with severe aortic stenosis the reclassification would result in approximately 1 life-year saved for every 30–35 patients in whom parasternal view were effectively utilized.

Published
2020

50. Clinical outcomes of PCI with rotational atherectomy: the European multicentre Euro4C registry

Author

Bouisset, Frédéric, primary, Barbato, Emanuele, additional, Reczuch, Krzysztof, additional, Dobrzycki, Slawomir, additional, Meyer-Gessner, Markus, additional, Bressollette, Erwan, additional, Cayla, Guillaume, additional, Lhermusier, Thibault, additional, Zajdel, Wojciech, additional, Palazuelos Molinero, Jorge, additional, Ferenc, Miroslaw, additional, Ribichini, Flavio L., additional, and Carrié, Didier, additional

Published
2020
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