18 results on '"Ribeiro EF"'
Search Results
2. Full-fat corn germ improves the performance and milk fat yield of Girolando cows fed sugarcane bagasse and cactus cladodes as forage sources.
- Author
-
da Silva CS, da Gama MAS, Silva EAM, Ribeiro EF, Felix SB, Monteiro CCF, Mora-Luna RE, de Oliveira JCV, Dos Santos DC, and de Ferreira MA
- Subjects
- Female, Cattle, Animals, Milk metabolism, Cellulose metabolism, Zea mays, Lactation, Diet veterinary, Dietary Carbohydrates metabolism, Digestion, Rumen metabolism, Silage analysis, Saccharum, Cactaceae
- Abstract
We investigated the effects of replacing ground corn with full-fat corn germ (FFCG) on milk production, milk composition, and nutrient use in cows fed sugarcane bagasse and cactus cladodes. Ten multiparous Girolando cows (average body weight 500 ± 66 kg, 90 ± 15 days in milk) were distributed in a replicated 5 × 5 Latin Square and assigned to five dietary treatments containing 0%, 25%, 50%, 75%, or 100% of full-fat corn germ in substitution to ground corn. Full-fat corn germ increased fat-corrected milk yield by 2.2 kg/day and the synthesis of fat, lactose, and total solids in milk by 94.4, 60.0, and 201.10 g/day, respectively (p < 0.05). Cows fed corn germ quadratically increased (p < 0.05) dry matter intake by 1.01 kg/day, with the intake of crude protein and total digestible nutrients following the same pattern. Conversely, the substitution of corn for full-fat corn germ linearly reduced (p < 0.05) the total non-fiber carbohydrate intake from 5.79 to 4.40 kg/d. Except for ether extract and non-fiber carbohydrates, full-fat corn germ did not alter (p > 0.05) nutrient digestibility. Cows fed corn germ excreted less (p < 0.05) urea-N in milk and urine N. These results demonstrate that full-fat corn germ can partially replace ground corn to enhance the milk production efficiency of crossbred cows fed cactus cladodes and sugarcane bagasse. Furthermore, including sugarcane bagasse in FFCG-supplemented diets prevents milk fat depression in cows fed cactus cladodes., (© 2024. The Author(s), under exclusive licence to Springer Nature B.V.)
- Published
- 2024
- Full Text
- View/download PDF
3. Cactus cladodes for dairy goats: what is the best fiber source?
- Author
-
de Lima IE, Monteiro CC, Mesquita FTL, de Vasconcelos EQL, de Souza MS, Dos Santos DS, Ribeiro EF, Santos TVM, Félix SB, Herrera AM, and de Andrade Ferreira M
- Subjects
- Female, Animals, Cellulose metabolism, Dietary Fiber metabolism, Lactation, Digestion, Diet veterinary, Milk metabolism, Silage analysis, Zea mays metabolism, Goats metabolism, Rumen metabolism, Cactaceae, Saccharum
- Abstract
This study evaluated the effect of different fiber sources supplied with cactus cladodes in diets on the intake and digestibility of nutrients, ingestive behavior, milk yield, and composition of dairy goats. The fiber sources were corn silage, sorghum silage, Digitaria pentzii Stent. hay, and sugarcane bagasse. Twelve Saanen goats with an average weight of 48.9 ± 7.3 kg and average production of 2.8 ± 0.7 kg of milk/day were assigned in three simultaneous 4 × 4 Latin squares (four animals, four treatments, and four experimental periods). There was no difference between the fiber sources for intake (P > 0.05) of dry matter (2.58 kg/day), organic matter (2.30 kg/day), crude protein (0.385 kg/day), neutral detergent fiber (0.895 kg/day), non-fibrous carbohydrates (0.858 kg/day), and metabolizable energy (5.66 Mcal/day). Also, the fiber sources did not influence dry matter and nutrient digestibility (P > 0.05). The association of cactus cladodes with silages, hay, and sugarcane bagasse did not change milk production, milk production corrected for 3.5% of fat and corrected for energy (2.78; 2.53 and 2,55 kg/day, respectively), in addition to milk composition (P > 0.05). No differences were observed in ingestive behavior (P > 0.05). Any fiber sources evaluated are recommended., (© 2023. The Author(s), under exclusive licence to Springer Nature B.V.)
- Published
- 2023
- Full Text
- View/download PDF
4. Nutritional Quality of Milk Fat from Cows Fed Full-Fat Corn Germ in Diets Containing Cactus Opuntia and Sugarcane Bagasse as Forage Sources.
- Author
-
Silva CSD, Gama MAS, Silva EAM, Ribeiro EF, Souza FG, Monteiro CCF, Mora-Luna RE, Oliveira JCV, Santos DC, and Ferreira MA
- Abstract
We evaluated the performance, milk composition, and milk fatty acid profile of cows fed diets composed of cactus cladodes ( Opuntia stricta [Haw.] Haw), sugarcane bagasse and increasing levels of full-fat corn germ (FFCG). We hypothesized that ground corn can be effectively replaced by FFCG when cactus cladodes and sugarcane bagasse are used as forage sources. The cows were randomly distributed into two 5 × 5 Latin Squares and fed five diets in which ground corn was progressively replaced with full-fat corn germ (FFCG; 0%, 25%, 50%, 75%, or 100% of substitution). Adding FFCG to the diet increased milk production and milk fat content and reduced milk protein content. Overall, FFCG reduced the proportion of saturated FAs and increased mono- and polyunsaturated FAs in milk, including CLA isomers. In addition, activity indices of stearoyl-CoA desaturase were reduced by increasing levels of FFCG. We conclude that the substitution of corn for FFCG in diets based on cactus cladodes and sugarcane bagasse positively modifies the FA profile of milk and could add commercial value to milk products (e.g., CLA-enriched milk). In addition, the milk fat response indicates that the basal diet was favorable to the rumen environment, preventing the trans-10 shift commonly associated with milk fat depression.
- Published
- 2023
- Full Text
- View/download PDF
5. The Advances in Glioblastoma On-a-Chip for Therapy Approaches.
- Author
-
Alves AH, Nucci MP, Mamani JB, Valle NME, Ribeiro EF, Rego GNA, Oliveira FA, Theinel MH, Santos RS, and Gamarra LF
- Abstract
This systematic review aimed to verify the use of microfluidic devices in the process of implementing and evaluating the effectiveness of therapeutic approaches in glioblastoma on-a-chip, providing a broad view of advances to date in the use of this technology and their perspectives. We searched studies with the variations of the keywords "Glioblastoma", "microfluidic devices", "organ-on-a-chip" and "therapy" of the last ten years in PubMed and Scopus databases. Of 446 articles identified, only 22 articles were selected for analysis according to the inclusion and exclusion criteria. The microfluidic devices were mainly produced by soft lithography technology, using the PDMS material (72%). In the microenvironment, the main extracellular matrix used was collagen type I. Most studies used U87-MG glioblastoma cells from humans and 31.8% were co-cultivated with HUVEC, hCMEC/D3, and astrocytes. Chemotherapy was the majority of therapeutic approaches, assessing mainly the cellular viability and proliferation. Furthermore, some alternative therapies were reported in a few studies (22.6%). This study identified a diversity of glioblastoma on-a-chip to assess therapeutic approaches, often using intermediate levels of complexity. The most advanced level implemented the intersection between different biological systems (liver-brain or intestine-liver-brain), BBB model, allowing in vitro studies with greater human genetic similarity, reproducibility, and low cost, in a highly customizable platform.
- Published
- 2022
- Full Text
- View/download PDF
6. Chitosan and crosslinked chitosan nanoparticles: Synthesis, characterization and their role as Pickering emulsifiers.
- Author
-
Ribeiro EF, de Barros-Alexandrino TT, Assis OBG, Junior AC, Quiles A, Hernando I, and Nicoletti VR
- Abstract
Chitosan has been modified in order to produce nanoparticles with promising characteristics in diverse food applications, e.g. Pickering emulsions. Chitosan deprotonation and ionic crosslinking with tripolyphosphate were assessed in this work. Chitosan nanoparticles produced by these two methods were characterized according to surface charge, particle size distribution, chemical structure, wettability and microstructure imaging. The nanoparticles' performance in the formation of oil-in-water Pickering emulsions was studied by physicochemical and rheological assays. Chitosan nanoparticles produced by amino deprotonation were larger and resulted in emulsions with larger oil droplets, with rheological behavior of the emulsions being greatly affected by increasing concentration of chitosan, which formed a network structure in the continuous phase. On the contrary, the tripolyphosphate-crosslinked chitosan nanoparticles were smaller and produced emulsions with smaller droplets, which remained less viscous even when chitosan concentration was increased and showed evidences of Pickering stabilization when analyzed by microscopy techniques., (Copyright © 2020 Elsevier Ltd. All rights reserved.)
- Published
- 2020
- Full Text
- View/download PDF
7. Erratum to "Diagnosis and treatment of chronic lymphocytic leukemia: Recommendations from the Brazilian Group of Chronic Lymphocytic Leukemia" [Rev Bras Hematol Hemoter. 2016;38(4):346-357].
- Author
-
Rodrigues CA, Gonçalves MV, Ikoma MR, Lorand-Metze I, Pereira AD, Farias DL, Chauffaille ML, Schaffel R, Ribeiro EF, Rocha TS, Buccheri V, Vasconcelos Y, Figueiredo VL, Chiattone CS, and Yamamoto M
- Published
- 2017
- Full Text
- View/download PDF
8. Acute myelomonocytic leukemia and leukocytoclastic vasculitis.
- Author
-
Dos Santos VM, Ribeiro EF, Dos Santos UM, Ribeiro KR, Araújo MC, and Fachinelli LR
- Published
- 2016
- Full Text
- View/download PDF
9. Diagnosis and treatment of chronic lymphocytic leukemia: recommendations from the Brazilian Group of Chronic Lymphocytic Leukemia.
- Author
-
Rodrigues CA, Gonçalves MV, Ikoma MR, Lorand-Metze I, Pereira AD, Farias DL, Chauffaille ML, Schaffel R, Ribeiro EF, Rocha TS, Buccheri V, Vasconcelos Y, Figueiredo VL, Chiattone CS, and Yamamoto M
- Abstract
Chronic lymphocytic leukemia is characterized by clonal proliferation and progressive accumulation of B-cell lymphocytes that typically express CD19
+ , CD5+ and CD23+ . The lymphocytes usually infiltrate the bone marrow, peripheral blood, lymph nodes, and spleen. The diagnosis is established by immunophenotyping circulating B-lymphocytes, and prognosis is defined by two staging systems (Rai and Binet) established by physical examination and blood counts, as well as by several biological and genetic markers. In this update, we present the recommendations from the Brazilian Group of Chronic Lymphocytic Leukemia for the diagnosis and treatment of chronic lymphocytic leukemia. The following recommendations are based on an extensive literature review with the aim of contributing to more uniform patient care in Brazil and possibly in other countries with a similar social-economic profile., (Copyright © 2016 Associação Brasileira de Hematologia, Hemoterapia e Terapia Celular. Published by Elsevier Editora Ltda. All rights reserved.)- Published
- 2016
- Full Text
- View/download PDF
10. A 61-year-old woman with adult T-cell leukemia÷lymphoma.
- Author
-
Dos Santos VM, Ribeiro EF, de Faria PS, Barros IA, and Oliveira MM
- Subjects
- Colonoscopy, Fatal Outcome, Female, Humans, Middle Aged, T-Lymphocytes pathology, Tomography, X-Ray Computed, Leukemia-Lymphoma, Adult T-Cell pathology
- Abstract
Adult T-cell leukemia÷lymphoma (ATL) is caused by human T-cell lymphotropic virus type-1 (HTLV-1) infection. Classification of ATL includes acute, chronic, lymphomatous and smoldering, and main features are hypercalcemia, organomegaly, bone, brain, lung, and skin changes. Elevated mortality rates of ATL may be due to the advanced age at diagnosis, because this malignancy can evolve unsuspected for decades before the first clinical manifestations. Palliative therapy, chemotherapy and stem cell transplantation are often utilized, but response to treatment is poor. The patient herein reported presented diffuse abdominal pain with duration of eight months in addition to ascites. The diagnosis of the acute leukemia type of ATL was done with base on clinical, laboratory and imaging findings. Gastrointestinal symptoms and ascites are uncommon first manifestations of ATL, and pose challenging diagnosis.
- Published
- 2016
11. Impact of Bariatric Surgery on Patients from Goiás, Brazil, Using the BAROS Method - A Preliminary Study.
- Author
-
Ribeiro EF, de Ávila RI, de Sousa Santos RR, and Garrote CFD
- Abstract
Introduction: As obesity is currently a major public health problem, bariatric surgery has been widely indicated due to the difficulties involved in the clinical management of obese adults., Objectives: Assess the quality-of-life (QOL) of patients who had undergone Roux-en-Y Gastric Bypass (RYGB) in the State of Goiás, Brazil, where as yet no studies have been published on the QOL of patients who underwent bariatric surgery., Methods: A retrospective study, using the Bariatric Analysis and Reporting Outcome System (BAROS), was carried out in Goiânia and Rio Verde, Goiás, Brazil, with 50 over 18-year-old patients of both genders, who had undergone RYGB and had at least three months of postoperative time., Results: Before RYGB, 48% of the individuals were classified as morbidly obese. Average weight and body mass index (BMI) of the 50 patients interviewed were 119.37 ± 18.44 kg and 43.54 ± 5.33 kg/m
2 , respectively. By contrast, after the RYGB these parameters decreased significantly to 78.01 ± 11.06 kg and 28.46 ± 3.61 kg/m2 , respectively, mainly from the 3rd to 85th month of postoperative time ( p < 0.0001). As well as that, 78% reported having presented preoperative comorbidities, especially hypertension (44%), rheumatism (34%), dyslipidemia (24%) and diabetes (20%). However, after surgery, the resolution rates were 77, 24, 100 and 100%, respectively, for these same clinical conditions. In terms of QOL, some patients reported feeling better (8%) or much better (92%) after RYGB. The outcome of the BAROS method for those patients was classified as fair (2%), good (8%), very good (24%) and excellent (66%)., Conclusions: Preliminary results indicated that RYGB could be a successful surgical procedure to promote satisfactory and sustained reduction in the body measurements of morbidly obese patients from Goiás, Brazil. Furthermore, the final BAROS score showed improvements in associated comorbidity and also in the QOL of these patients.- Published
- 2015
- Full Text
- View/download PDF
12. Diuretic effects and urinary electrolyte excretion induced by Aspidosperma subincanum Mart. and the involvement of prostaglandins in such effects.
- Author
-
Ribeiro EF, de Fátima Reis C, de Carvalho FS, Abreu JP, Arruda AF, Garrote CF, and Rocha ML
- Subjects
- Animals, Cyclooxygenase Inhibitors pharmacology, Female, Piroxicam pharmacology, Plant Bark, Potassium urine, Prostaglandins metabolism, Rats, Wistar, Sodium urine, Aspidosperma, Diuretics pharmacology, Plant Extracts pharmacology
- Abstract
Ethnopharmacological Relevance: Aspidosperma subincanum Mart. is a medicinal herb known for its diuretic properties and used for the treatment of cardiovascular-related illnesses. Although our earlier study has shown that the ethanol extract of Aspidosperma subincanum (EEAS) induces hypotension and vasodilation, no scientific data have been recorded to evaluate the diuretic effects of this Brazilian medicinal plant. The aim of this study was to evaluate the diuretic activity of EEAS, and possible mechanism of action, using Wistar rats., Material and Methods: EEAS (60 and 120mg/kg), furosemide (20mg/kg) or saline (control) were orally administered to rats individually held in metabolic cages for urine collection 1, 2, 4, 6, 8, 12 and 24h after treatment. In order to evaluate the involvement of prostaglandins in the diuretic action of EEAS, the animals received piroxicam (5mg/kgi.p.), a nonselective inhibitor of cyclooxygenase, before treatment with EEAS at 120mg/kg. The control groups received only saline (NaCl, 0.9%), or saline and piroxicam. Urinary volume, electrolyte excretion and pH were measured., Results: Oral administration of EEAS 60 and 120mg/kg significantly increased diuresis and electrolyte excretion of Na(+) and K(+) on a continuous basis throughout the study period. Both EEAS 60 and 120mg/kg caused a relative increase of around 77% and 142%, respectively, in cumulative diuresis compared with the control group. From 4th hour until the end of the experiment, the group treated with EEAS 120mg/kg provided a greater excretion of Na(+) than the furosemide group. The diuretic effects of EEAS were neutralized by piroxicam between 4 and 8h after treatment., Conclusion: The results suggest that EEAS could present compound(s) responsible for diuretic activities, and the mechanism could involve the prostaglandin system., (Copyright © 2015 Elsevier Ireland Ltd. All rights reserved.)
- Published
- 2015
- Full Text
- View/download PDF
13. The effect of carbon dioxide therapy on composite graft survival.
- Author
-
Durães EF, Durães Lde C, Carneiro FP, Lino Rde S Jr, and Sousa JB
- Subjects
- Animals, Collagen analysis, Male, Rabbits, Random Allocation, Reproducibility of Results, Sodium Chloride, Treatment Outcome, Wound Healing drug effects, Carbon Dioxide therapeutic use, Ear Auricle transplantation, Graft Survival drug effects
- Abstract
Purpose: To investigate the effect of carboxytherapy in auricular composite grafts in rabbits., Methods: An experimental study was conducted using 20 rabbits randomly assigned to a treatment group of carboxytherapy or a control group of saline solution. In each ear, a circular graft with 1.5 cm or 2 cm of diameter was amputated and reattached. Animals underwent carbon dioxide or saline injection four times during the experiment. We analyzed clinical evolution of the animals, grafts survival, histopathology features and histomorphometry of collagen., Results: The treated group had a significantly lower weight gain (p=0.038). Histopathology was not significantly different between groups. There was an increase in amount of collagen in 2 cm grafts submitted to carbon dioxide therapy (p=0.003). Carboxytherapy didn't influence graft survival rate for 1.5 cm grafts or 2 cm grafts (p=0.567 and p=0.777, respectively)., Conclusions: Carbon dioxide therapy increased the amount of collagen in 2 cm grafts. CO2 was not significantly different from saline infusion on composite grafts survival, but this study suggests that there is a mechanical effect caused by distension which favored graft survival.
- Published
- 2013
- Full Text
- View/download PDF
14. Correlation between bursting pressure and breaking strength in colonic anastomosis.
- Author
-
Durães Lde C, Durães EF, Lobato LF, Oliveira PG, and Sousa JB
- Subjects
- Anastomosis, Surgical, Animals, Colon pathology, Male, Pneumoperitoneum, Artificial, Postoperative Period, Random Allocation, Rats, Rats, Wistar, Reference Values, Time Factors, Tissue Adhesions, Wound Healing physiology, Colon surgery, Pressure adverse effects, Tensile Strength physiology
- Abstract
Purpose: To investigate the correlation between bursting pressure and breaking strength on the 7th postoperative day following left colonic anastomosis in rats., Methods: Seventy rats were randomly divided into seven groups of ten animals each. All of the animals underwent segmental resection of the left colon and end-to-end anastomosis. The animals in groups I to VI underwent surgical laparoscopies with pneumoperitoneums using carbon dioxide or helium at pressures of 5, 12 or 20 mmHg. In Group VII, open laparotomy was performed. The animals were reoperated on postoperative day 7 to measure the bursting pressure and the breaking strength of the anastomosis., Results: The anastomosis bursting pressure in 70 animals was 193.10±55.56 mmHg. There was no significant difference between the groups (p=0.786). The breaking strength of the anastomosis was 0.26±0.12 N. There was no significant difference between the groups (p=0.356). Pearson's correlation test showed a low correlation (r=0.231) lacking statistical significance (p=0.054)., Conclusion: There was no correlation between the bursting pressure and breaking strength of left colonic anastomoses in rats on the 7th postoperative day.
- Published
- 2013
- Full Text
- View/download PDF
15. Effects of carbon dioxide therapy on the healing of acute skin wounds induced on the back of rats.
- Author
-
Penhavel MV, Nascimento VH, Durães EF, Carneiro FP, and Sousa JB
- Subjects
- Animals, Male, Neovascularization, Physiologic drug effects, Postoperative Period, Random Allocation, Rats, Rats, Wistar, Reference Values, Skin pathology, Time Factors, Treatment Outcome, Wound Healing physiology, Wounds and Injuries drug therapy, Carbon Dioxide therapeutic use, Skin injuries, Wound Healing drug effects
- Abstract
Purpose: To evaluate the healing effect of carbon dioxide therapy on skin wounds induced on the back of rats., Methods: Sixteen rats underwent excision of a round dermal-epidermal dorsal skin flap of 2.5 cm in diameter. The animals were divided into two groups, as follows: carbon dioxide group - subcutaneous injections of carbon dioxide on the day of operation and at three, six and nine days postoperatively; control group - no postoperative wound treatment. Wounds were photographed on the day of operation and at six and 14 days postoperatively for analysis of wound area and major diameter. All animals were euthanized on day 14 after surgery. The dorsal skin and the underlying muscle layer containing the wound were resected for histopathological analysis., Results: There was no statistically significant difference between groups in the percentage of wound closure, in histopathological findings, or in the reduction of wound area and major diameter at 14 days postoperatively., Conclusion: Under the experimental conditions in which this study was conducted, carbon dioxide therapy had no effects on the healing of acute skin wounds in rats.
- Published
- 2013
- Full Text
- View/download PDF
16. A new proposal for laparoscopic left colectomy in a rat model.
- Author
-
Durães Lde C, Durães EF, Freitas PF, Carvalho FA, Carvalho SA, and Sousa JB
- Subjects
- Anastomosis, Surgical methods, Animals, Feasibility Studies, Models, Animal, Random Allocation, Rats, Rats, Wistar, Reproducibility of Results, Time Factors, Colectomy methods, Colon surgery, Laparoscopy methods
- Abstract
Purpose: To evaluate the feasibility and safety of a new technique for laparoscopic segmental colectomy and primary anastomosis in the left colon of rats., Methods: Thirty rats were randomly assigned to three groups of ten animals each. All animals underwent segmental resection of the left colon and end-to-end anastomosis. In Group I, the animals underwent laparoscopic surgery with carbon dioxide pneumoperitoneum at a pressure of 5 mmHg. In Group II, the animals underwent pneumoperitoneum with carbon dioxide at a pressure of 12 mmHg. In Group III, the control group, the animals underwent open surgery. All animals were reopened on the 7th postoperative day and were evaluated for peritonitis, abscesses, anastomotic dehiscence and bowel obstruction, and the anastomosis bursting pressure was measured., Results: No obstructions, peritonitis or abscesses were found in any of the animals. An animal in Group I exhibited a blocked anastomosis leakage. The average anastomosis bursting pressure in the 30 animals was 187.02 ± 68.35 mmHg. There was no significant difference in the anastomosis bursting pressure among the groups (p = 0.503), Conclusion: The laparoscopic experimental model was feasible and safe for segmental colectomy and anastomosis of the left colon in rats.
- Published
- 2013
- Full Text
- View/download PDF
17. Mucormycosis in a patient with acute myeloid leukemia successfully treated with liposomal amphotericin B associated with deferasirox and hyperbaric oxygen.
- Author
-
Ribeiro EF, dos Santos VM, Paixão GT, Cruz LR, Danilow MZ, and Campos VF
- Subjects
- Adult, Bone Marrow pathology, Deferasirox, Drug Therapy, Combination, Female, Humans, Hyperbaric Oxygenation, Immunophenotyping, Karyotyping, Mucormycosis drug therapy, Nucleophosmin, Treatment Outcome, Amphotericin B administration & dosage, Antifungal Agents administration & dosage, Benzoates administration & dosage, Leukemia, Myeloid, Acute complications, Mucormycosis diagnosis, Mucormycosis pathology, Triazoles administration & dosage
- Abstract
We report a 38-year-old woman presenting with febrile neutropenia, acute myeloid leukemia (AML) and invasive mucormycosis. Bone marrow aspirate was characteristic of AML minimally differentiated (WHO classification 2008). Flow cytometric immunophenotyping analysis showed blasts positive for CD7, CD33, CD34, CD71, CD117, HLA-DR, MPO, and TdT, with normal karyotype (46, XX), and the absence of the FLT3-ITD and NPM1 mutations. The patient's management included chemotherapy with cytarabine and idarubicin, and treatment with liposomal amphotericin B, deferasirox, hyperbaric oxygen therapy, and antibiotics. Nowadays, she is in complete hematological remission, and CT images of control are normal. Invasive mucormycosis is an uncommon and severe condition, which involves diagnosis and treatment challenges. Clinical features and predisposing factors should be highlighted in order to enhance the suspicion index, contributing to early diagnosis and disease control. Our aim is to report classical features of this uncommon condition and to emphasize usual management challenges.
- Published
- 2013
- Full Text
- View/download PDF
18. Glomus tumor of the stomach: a rare cause of upper gastrointestinal bleeding.
- Author
-
Nascimento EF, Fonte FP, Mendonça RL, Nonose R, de Souza CA, and Martinez CA
- Abstract
Introduction. Glomus tumors (GTs) are benign neoplasm originating from the glomus body, commonly described in subungual region. The involvement abdominal is rare. Our aim is to describe a case of glomus tumor of the stomach that presented upper gastrointestinal bleeding. A 34-year-old woman was admitted with upper gastrointestinal bleeding and underwent an upper endoscopy that showed bleeding arising from an ulcerated lesion, treated by sclerosis therapy. A new endoscopy confirmed a submucosal lesion in upper portion of the stomach. During the laparotomy, a tumor at the upper anterior wall of gastric body was found and resected by a vertical gastrectomy. The pathological exam revealed hyperplastic smooth muscle fibers of the muscularis propria of the stomach wall, surrounded by hyaline stroma. The immunohistochemistry panel was positive for smooth muscle actin and type IV collagen, with low rate of mitosis studied by Ki-67 which allowed the final diagnosis of a gastric glomus tumor. Discussion. The majority of intraperitoneal glomus tumors occur in the stomach, and it is phenotypically similar to those localized in peripheral sites. Gastric GT generally is a benign tumor although it can be malignant and have the potential to metastasize. Conclusion. Even though gastric glomus tumor is rarely described, it should be considered as a possible cause of a major upper gastrointestinal bleeding.
- Published
- 2011
- Full Text
- View/download PDF
Catalog
Discovery Service for Jio Institute Digital Library
For full access to our library's resources, please sign in.