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2. An Integrative Sialomic Analysis Reveals Molecules From Triatoma sordida (Hemiptera: Reduviidae)

Author

Praça, Yanna Reis, primary, Santiago, Paula Beatriz, additional, Charneau, Sébastien, additional, Mandacaru, Samuel Coelho, additional, Bastos, Izabela Marques Dourado, additional, Bentes, Kaio Luís da Silva, additional, Silva, Sofia Marcelino Martins, additional, da Silva, Waldeyr Mendes Cordeiro, additional, da Silva, Ionizete Garcia, additional, de Sousa, Marcelo Valle, additional, Soares, Célia Maria de Almeida, additional, Ribeiro, José Marcos Chaves, additional, Santana, Jaime Martins, additional, and de Araújo, Carla Nunes, additional

Published
2022
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3. Immune recognition of salivary proteins from the cattle tick Rhipicephalus microplus differs according to the genotype of the bovine host

Author

Garcia, Gustavo Rocha, Maruyama, Sandra Regina, Nelson, Kristina T, Ribeiro, José Marcos Chaves, Gardinassi, Luiz Gustavo, Maia, Antonio Augusto Mendes, Ferreira, Beatriz Rossetti, Kooyman, Frans N J, de Miranda Santos, Isabel K F, Garcia, Gustavo Rocha, Maruyama, Sandra Regina, Nelson, Kristina T, Ribeiro, José Marcos Chaves, Gardinassi, Luiz Gustavo, Maia, Antonio Augusto Mendes, Ferreira, Beatriz Rossetti, Kooyman, Frans N J, and de Miranda Santos, Isabel K F

Abstract

BACKGROUND: Males of the cattle tick Rhipicephalus microplus produce salivary immunoglobulin-binding proteins and allotypic variations in IgG are associated with tick loads in bovines. These findings indicate that antibody responses may be essential to control tick infestations. Infestation loads with cattle ticks are heritable: some breeds carry high loads of reproductively successful ticks, in others, few ticks feed and they reproduce inefficiently. Different patterns of humoral immunity against tick salivary proteins may explain these phenotypes.METHODS: We describe the profiles of humoral responses against tick salivary proteins elicited during repeated artificial infestations of bovines of a tick-resistant (Nelore) and a tick-susceptible (Holstein) breed. We measured serum levels of total IgG1, IgG2 and IgE immunoglobulins and of IgG1 and IgG2 antibodies specific for tick salivary proteins. With liquid chromatography followed by mass spectrometry we identified tick salivary proteins that were differentially recognized by serum antibodies from tick-resistant and tick-susceptible bovines in immunoblots of tick salivary proteins separated by two-dimensional electrophoresis.RESULTS: Baseline levels of total IgG1 and IgG2 were significantly higher in tick-susceptible Holsteins compared with resistant Nelores. Significant increases in levels of total IgG1, but not of IgG2 accompanied successive infestations in both breeds. Resistant Nelores presented with significantly higher levels of salivary-specific antibodies before and at the first challenge with tick larvae; however, by the third challenge, tick-susceptible Holsteins presented with significantly higher levels of IgG1 and IgG2 tick salivary protein-specific antibodies. Importantly, sera from tick-resistant Nelores reacted with 39 tick salivary proteins in immunoblots of salivary proteins separated in two dimensions by electrophoresis versus only 21 spots reacting with sera from tick-susceptible

Published
2017

4. Immune recognition of salivary proteins from the cattle tick Rhipicephalus microplus differs according to the genotype of the bovine host

Author

dI&I I&I-4, Garcia, Gustavo Rocha, Maruyama, Sandra Regina, Nelson, Kristina T, Ribeiro, José Marcos Chaves, Gardinassi, Luiz Gustavo, Maia, Antonio Augusto Mendes, Ferreira, Beatriz Rossetti, Kooyman, Frans N J, de Miranda Santos, Isabel K F, dI&I I&I-4, Garcia, Gustavo Rocha, Maruyama, Sandra Regina, Nelson, Kristina T, Ribeiro, José Marcos Chaves, Gardinassi, Luiz Gustavo, Maia, Antonio Augusto Mendes, Ferreira, Beatriz Rossetti, Kooyman, Frans N J, and de Miranda Santos, Isabel K F

Published
2017

5. Immune recognition of salivary proteins from the cattle tick Rhipicephalus microplus differs according to the genotype of the bovine host

Author

Garcia, Gustavo Rocha, Maruyama, Sandra Regina, Nelson, Kristina T, Ribeiro, José Marcos Chaves, Gardinassi, Luiz Gustavo, Maia, Antonio Augusto Mendes, Ferreira, Beatriz Rossetti, Kooyman, Frans N J, de Miranda Santos, Isabel K F, dI&I I&I-4, and dI&I I&I-4

Subjects
0301 basic medicine, Male, Saliva, Bostaurus, Genotype, Proteome, 030231 tropical medicine, Cattle Diseases, Immunoglobulins, Bos indicus, Tick, SALIVA, Arthropod Proteins, 03 medical and health sciences, 0302 clinical medicine, Blood serum, Tick saliva, parasitic diseases, Rhipicephalus, Animals, Salivary Proteins and Peptides, Immunoproteome, biology, Research, biology.organism_classification, bacterial infections and mycoses, Bos taurus, Tick Infestations, 030104 developmental biology, Infectious Diseases, Parasitology, Rhipicephalus microplus, Immunology, Humoral immunity, Antibody response, biology.protein, Cattle, Female, Antibody
Abstract

Background Males of the cattle tick Rhipicephalus microplus produce salivary immunoglobulin-binding proteins and allotypic variations in IgG are associated with tick loads in bovines. These findings indicate that antibody responses may be essential to control tick infestations. Infestation loads with cattle ticks are heritable: some breeds carry high loads of reproductively successful ticks, in others, few ticks feed and they reproduce inefficiently. Different patterns of humoral immunity against tick salivary proteins may explain these phenotypes. Methods We describe the profiles of humoral responses against tick salivary proteins elicited during repeated artificial infestations of bovines of a tick-resistant (Nelore) and a tick-susceptible (Holstein) breed. We measured serum levels of total IgG1, IgG2 and IgE immunoglobulins and of IgG1 and IgG2 antibodies specific for tick salivary proteins. With liquid chromatography followed by mass spectrometry we identified tick salivary proteins that were differentially recognized by serum antibodies from tick-resistant and tick-susceptible bovines in immunoblots of tick salivary proteins separated by two-dimensional electrophoresis. Results Baseline levels of total IgG1 and IgG2 were significantly higher in tick-susceptible Holsteins compared with resistant Nelores. Significant increases in levels of total IgG1, but not of IgG2 accompanied successive infestations in both breeds. Resistant Nelores presented with significantly higher levels of salivary-specific antibodies before and at the first challenge with tick larvae; however, by the third challenge, tick-susceptible Holsteins presented with significantly higher levels of IgG1 and IgG2 tick salivary protein-specific antibodies. Importantly, sera from tick-resistant Nelores reacted with 39 tick salivary proteins in immunoblots of salivary proteins separated in two dimensions by electrophoresis versus only 21 spots reacting with sera from tick-susceptible Holsteins. Conclusions Levels of tick saliva-specific antibodies were not directly correlated with infestation phenotypes. However, in spite of receiving apparently lower amounts of tick saliva, tick-resistant bovines recognized more tick salivary proteins. These reactive salivary proteins are putatively involved in several functions of parasitism and blood-feeding. Our results indicate that neutralization by host antibodies of tick salivary proteins involved in parasitism is essential to control tick infestations. Electronic supplementary material The online version of this article (doi:10.1186/s13071-017-2077-9) contains supplementary material, which is available to authorized users.

Published
2016

6. Immune recognition of salivary proteins from the cattle tick Rhipicephalus microplus differs according to the genotype of the bovine host

Author

Garcia, Gustavo Rocha, primary, Maruyama, Sandra Regina, additional, Nelson, Kristina T., additional, Ribeiro, José Marcos Chaves, additional, Gardinassi, Luiz Gustavo, additional, Maia, Antonio Augusto Mendes, additional, Ferreira, Beatriz Rossetti, additional, Kooyman, Frans N. J., additional, and de Miranda Santos, Isabel K. F., additional

Published
2017
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7. Immune and biochemical responses in skin differ between bovine hosts genetically susceptible and resistant to the cattle tick Rhipicephalus microplus

Author

Franzin, Alessandra Mara, primary, Maruyama, Sandra Regina, additional, Garcia, Gustavo Rocha, additional, Oliveira, Rosane Pereira, additional, Ribeiro, José Marcos Chaves, additional, Bishop, Richard, additional, Maia, Antônio Augusto Mendes, additional, Moré, Daniela Dantas, additional, Ferreira, Beatriz Rossetti, additional, and Santos, Isabel Kinney Ferreira de Miranda, additional

Published
2017
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8. Characterisation of divergent flavivirus NS3 and NS5 protein sequences detected in Rhipicephalus microplus ticks from Brazil

Author

Maruyama, Sandra Regina, primary, Castro-Jorge, Luiza Antunes, additional, Ribeiro, José Marcos Chaves, additional, Gardinassi, Luiz Gustavo, additional, Garcia, Gustavo Rocha, additional, Brandão, Lucinda Giampietro, additional, Rodrigues, Aline Rezende, additional, Okada, Marcos Ituo, additional, Abrão, Emiliana Pereira, additional, Ferreira, Beatriz Rossetti, additional, Fonseca, Benedito Antonio Lopes da, additional, and Miranda-Santos, Isabel Kinney Ferreira de, additional

Published
2014
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9. Glycoinositolphospholipids from Trypanosomatids Subvert Nitric Oxide Production in Rhodnius prolixus Salivary Glands

Author

Gazos-Lopes, Felipe, primary, Mesquita, Rafael Dias, additional, Silva-Cardoso, Lívia, additional, Senna, Raquel, additional, Silveira, Alan Barbosa, additional, Jablonka, Willy, additional, Cudischevitch, Cecília Oliveira, additional, Carneiro, Alan Brito, additional, Machado, Ednildo Alcantara, additional, Lima, Luize G., additional, Monteiro, Robson Queiroz, additional, Nussenzveig, Roberto Henrique, additional, Folly, Evelize, additional, Romeiro, Alexandre, additional, Vanbeselaere, Jorick, additional, Mendonça-Previato, Lucia, additional, Previato, José Osvaldo, additional, Valenzuela, Jesus G., additional, Ribeiro, José Marcos Chaves, additional, Atella, Georgia Correa, additional, and Silva-Neto, Mário Alberto Cardoso, additional

Published
2012
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10. Rhipicephalus (Boophilus) microplus: Clotting time in tick-infested skin varies according to local inflammation and gene expression patterns in tick salivary glands

Author

Carvalho, Wanessa Araújo, primary, Maruyama, Sandra Regina, additional, Franzin, Alessandra Mara, additional, Abatepaulo, Antônio Roberto Rodrigues, additional, Anderson, Jennifer M., additional, Ferreira, Beatriz Rossetti, additional, Ribeiro, José Marcos Chaves, additional, Moré, Daniela Dantas, additional, Augusto Mendes Maia, Antonio, additional, Valenzuela, Jesus G., additional, Garcia, Gustavo Rocha, additional, and de Miranda Santos, Isabel K. Ferreira, additional

Published
2010
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