274 results on '"Ria, F"'
Search Results
2. Secrets and lies of host-microbial interactions: MHC restriction and trans-regulation of T cell trafficking conceal the role of microbial agents on the edge between health and multifactorial/complex diseases
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Ria, Francesco, Delogu, Giovanni, Ingrosso, L, Sali, Michela, Di Sante, Gabriele, Ria, F (ORCID:0000-0002-8444-0307), Delogu, G (ORCID:0000-0003-0182-8267), Sali, M (ORCID:0000-0003-3609-2990), Di Sante, G (ORCID:0000-0001-6608-3388), Ria, Francesco, Delogu, Giovanni, Ingrosso, L, Sali, Michela, Di Sante, Gabriele, Ria, F (ORCID:0000-0002-8444-0307), Delogu, G (ORCID:0000-0003-0182-8267), Sali, M (ORCID:0000-0003-3609-2990), and Di Sante, G (ORCID:0000-0001-6608-3388)
- Abstract
Here we critically discuss data supporting the view that microbial agents (pathogens, pathobionts or commensals alike) play a relevant role in the pathogenesis of multifactorial diseases, but their role is concealed by the rules presiding over T cell antigen recognition and trafficking. These rules make it difficult to associate univocally infectious agents to diseases' pathogenesis using the paradigm developed for canonical infectious diseases. (Cross-)recognition of a variable repertoire of epitopes leads to the possibility that distinct infectious agents can determine the same disease(s). There can be the need for sequential infection/colonization by two or more microorganisms to develop a given disease. Altered spreading of infectious agents can determine an unwanted activation of T cells towards a pro-inflammatory and trafficking phenotype, due to differences in the local microenvironment. Finally, trans-regulation of T cell trafficking allows infectious agents unrelated to the specificity of T cell to modify their homing to target organs, thereby driving flares of disease. The relevant role of microbial agents in largely prevalent diseases provides a conceptual basis for the evaluation of more specific therapeutic approaches, targeted to prevent (vaccine) or cure (antibiotics and/or Biologic Response Modifiers) multifactorial diseases.
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- 2024
3. QUANTITATIVE EVALUATION OF RISK IN CT: MANAGING DOSE REDUCTION AND EFFECTIVE DIAGNOSIS
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Ria, F., primary
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- 2023
- Full Text
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4. DETECTABILITY INDEX TO STANDARDISE CT OPTIMIZAZION: A MULTICENTER STUDY
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Villa, R., primary, Daniotti, M., additional, Bertolini, M., additional, Cannillo, B., additional, Cavallari, M., additional, Cimolai, S., additional, D’Alessio, A., additional, De Marco, P., additional, De Mattia, C., additional, De Monte, F., additional, Felisi, M., additional, Ferrari, C., additional, Gilio, M.A., additional, Giovannini, G., additional, Lecchi, M., additional, Lisciandro, F., additional, Lizio, D., additional, Luraschi, F., additional, Mattacchioni, A., additional, Moresco, P., additional, Oberhofer, N., additional, Origgi, D.A., additional, Pietrobon, F., additional, Porzio, M., additional, Quattrocchi, M., additional, Ravaglia, V., additional, Ria, F., additional, Scabbio, C., additional, Strocchi, S., additional, Vaccara, E.M.L., additional, Zorz, A., additional, and Paruccini, N., additional
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- 2023
- Full Text
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5. Therapeutic Strategies to Prevent the Recurrence of Nasal Polyps after Surgical Treatment: An Update and In Vitro Study on Growth Inhibition of Fibroblasts
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Rizzi, Angela, Gammeri, L., Cordiano, R., Valentini, Mariagrazia, Centrone, M., Marrone, S., Inchingolo, Riccardo, Lohmeyer, F. M., Cavaliere, C., Ria, Francesco, Cadoni, Gabriella, Gangemi, S., Nucera, Eleonora, Rizzi A. (ORCID:0000-0002-6795-746X), Valentini M., Inchingolo R. (ORCID:0000-0003-2843-9966), Ria F. (ORCID:0000-0002-8444-0307), Cadoni G. (ORCID:0000-0001-8244-784X), Nucera E. (ORCID:0000-0002-0565-7680), Rizzi, Angela, Gammeri, L., Cordiano, R., Valentini, Mariagrazia, Centrone, M., Marrone, S., Inchingolo, Riccardo, Lohmeyer, F. M., Cavaliere, C., Ria, Francesco, Cadoni, Gabriella, Gangemi, S., Nucera, Eleonora, Rizzi A. (ORCID:0000-0002-6795-746X), Valentini M., Inchingolo R. (ORCID:0000-0003-2843-9966), Ria F. (ORCID:0000-0002-8444-0307), Cadoni G. (ORCID:0000-0001-8244-784X), and Nucera E. (ORCID:0000-0002-0565-7680)
- Abstract
Chronic rhinosinusitis with nasal polyps (CRSwNP) is the most bothersome phenotype of chronic rhinosinusitis, which is typically characterized by a Type 2 inflammatory reaction, comorbidities and high rates of nasal polyp recurrence, causing severe impact on quality of life. Nasal polyp recurrence rates, defined as the number of patients undergoing revision endoscopic sinus surgery, are 20% within a 5 year period after surgery. The cornerstone of CRSwNP management consists of anti-inflammatory treatment with local corticosteroids. We performed a literature review regarding the therapeutic strategies used to prevent nasal polyp recurrence after surgical treatment. Finally, we report an in vitro study evaluating the efficacy of lysine-acetylsalicylic acid and other non-steroidal anti-inflammatory drugs (ketoprofen and diclofenac) on the proliferation of fibroblasts, obtained from nasal polyp tissue samples. Our study demonstrates that diclofenac, even more so than lysine-acetylsalicylic acid, significantly inhibits fibroblast proliferation and could be considered a valid therapeutic strategy in preventing CRSwNP recurrence.
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- 2023
6. Fighting autoinflammation in FIRES: The role of interleukins and early immunomodulation
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Perulli, M., Cicala, G., Turrini, I., Musto, E., Quintiliani, M., Gambardella, M. L., Pulitano, S. M., Bompard, S., Staccioli, S., Carmillo, L., Di Sante, G., Ria, F., Veredice, C., Contaldo, I., Battaglia, D., Perulli M., Cicala G., Turrini I., Musto E., Quintiliani M., Gambardella M. L., Pulitano S. M. (ORCID:0000-0002-8496-379X), Bompard S., Staccioli S., Carmillo L., Di Sante G. (ORCID:0000-0001-6608-3388), Ria F. (ORCID:0000-0002-8444-0307), Veredice C., Contaldo I., Battaglia D. (ORCID:0000-0003-0491-4021), Perulli, M., Cicala, G., Turrini, I., Musto, E., Quintiliani, M., Gambardella, M. L., Pulitano, S. M., Bompard, S., Staccioli, S., Carmillo, L., Di Sante, G., Ria, F., Veredice, C., Contaldo, I., Battaglia, D., Perulli M., Cicala G., Turrini I., Musto E., Quintiliani M., Gambardella M. L., Pulitano S. M. (ORCID:0000-0002-8496-379X), Bompard S., Staccioli S., Carmillo L., Di Sante G. (ORCID:0000-0001-6608-3388), Ria F. (ORCID:0000-0002-8444-0307), Veredice C., Contaldo I., and Battaglia D. (ORCID:0000-0003-0491-4021)
- Abstract
Febrile infection-related epilepsy syndrome (FIRES) is a challenging condition with unfavorable outcome in most cases. Preliminary evidence suggests that some interleukins, in particular IL-1 Receptor Antagonist (IL-1RA), could be elevated due to a functional deficiency of anti-inflammatory pathways. Therefore, treatment strategies acting on innate immunity could represent a targeted treatment. We describe the case of an 11-year-old child with super-refractory status epilepticus (SE), lasting more than two months. After being treated aggressively with antiseizure medications, anesthetics and empiric treatment for autoimmune encephalitis without success, she responded to anakinra and ketogenic diet. Escalation of the therapy was supported by the finding of a very high serum level of IL-1RA. This immunomodulatory approach allowed to discharge the child from intensive care 48 days after the SE onset. After more than one year follow-up the patient has moderate intellectual disability but with good language skills; she is seizure free and without motor deficits. This case suggests that serum IL-1RA serum levels may help to support treatment escalation. Moreover, anakinra and ketogenic diet represent encouraging immunomodulatory strategies which deserve further studies and could potentially have a synergistic effect. Finally, structured neuropsychological testing is an important outcome measure that will help to define the effectiveness of different treatment strategies.
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- 2022
7. CO-11.5 - DETECTABILITY INDEX TO STANDARDISE CT OPTIMIZAZION: A MULTICENTER STUDY
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Villa, R., Daniotti, M., Bertolini, M., Cannillo, B., Cavallari, M., Cimolai, S., D’Alessio, A., De Marco, P., De Mattia, C., De Monte, F., Felisi, M., Ferrari, C., Gilio, M.A., Giovannini, G., Lecchi, M., Lisciandro, F., Lizio, D., Luraschi, F., Mattacchioni, A., Moresco, P., Oberhofer, N., Origgi, D.A., Pietrobon, F., Porzio, M., Quattrocchi, M., Ravaglia, V., Ria, F., Scabbio, C., Strocchi, S., Vaccara, E.M.L., Zorz, A., and Paruccini, N.
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- 2023
- Full Text
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8. SMA-miRs (MiR-181a- 5p, -324-5p, and -451a) are overexpressed in spinal muscular atrophy skeletal muscle and serum samples
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Abiusi, E., Infante, P., Cagnoli, C., Severini, L. L., Pane, M., Coratti, G., Pera, M. C., D'amico, A., Diano, F., Novelli, A., Spartano, S., Fiori, S., Baranello, G., Moroni, I., Mora, M., Pasanisi, M. B., Pocino, K., Le Pera, L., D'Amico, D., Travaglini, L., Ria, F., Bruno, C., Locatelli, D., Bertini, E. S., Morandi, L. O., Mercuri, E., Di Marcotullio, L., Tiziano, F. D., Abiusi E. (ORCID:0000-0001-9028-012X), Pane M. (ORCID:0000-0002-4851-6124), Coratti G. (ORCID:0000-0001-6666-5628), Pera M. C. (ORCID:0000-0001-6777-1721), D'amico A., Diano F., Novelli A., Spartano S., Fiori S., Baranello G., Pocino K. (ORCID:0000-0003-2456-5308), Ria F. (ORCID:0000-0002-8444-0307), Bertini E. S., Mercuri E. (ORCID:0000-0002-9851-5365), Tiziano F. D. (ORCID:0000-0002-5545-6158), Abiusi, E., Infante, P., Cagnoli, C., Severini, L. L., Pane, M., Coratti, G., Pera, M. C., D'amico, A., Diano, F., Novelli, A., Spartano, S., Fiori, S., Baranello, G., Moroni, I., Mora, M., Pasanisi, M. B., Pocino, K., Le Pera, L., D'Amico, D., Travaglini, L., Ria, F., Bruno, C., Locatelli, D., Bertini, E. S., Morandi, L. O., Mercuri, E., Di Marcotullio, L., Tiziano, F. D., Abiusi E. (ORCID:0000-0001-9028-012X), Pane M. (ORCID:0000-0002-4851-6124), Coratti G. (ORCID:0000-0001-6666-5628), Pera M. C. (ORCID:0000-0001-6777-1721), D'amico A., Diano F., Novelli A., Spartano S., Fiori S., Baranello G., Pocino K. (ORCID:0000-0003-2456-5308), Ria F. (ORCID:0000-0002-8444-0307), Bertini E. S., Mercuri E. (ORCID:0000-0002-9851-5365), and Tiziano F. D. (ORCID:0000-0002-5545-6158)
- Abstract
Background: Spinal muscular atrophy (SMA) is a neuromuscular disorder characterized by the degeneration of the second motor neuron. The phenotype ranges from very severe to very mild forms. All patients have the homozygous loss of the SMN1 gene and a variable number of SMN2 (generally 2–4 copies), inversely related to the severity. The amazing results of the available treatments have made compelling the need of prognostic biomarkers to predict the progression trajectories of patients. Besides the SMN2 products, few other biomarkers have been evaluated so far, including some miRs. Methods: We performed whole miRNome analysis of muscle samples of patients and controls (14 biopsies and 9 cultures). The levels of muscle differentially expressed miRs were evaluated in serum samples (51 patients and 37 controls) and integrated with SMN2 copies, SMN2 full-length transcript levels in blood and age (SMA-score). Results: Over 100 miRs were differentially expressed in SMA muscle; 3 of them (hsa-miR-181a-5p, -324-5p, -451a; SMA-miRs) were significantly upregulated in the serum of patients. The severity predicted by the SMA-score was related to that of the clinical classification at a correlation coefficient of 0.87 (p<10-5). Conclusions: MiRNome analyses suggest the primary involvement of skeletal muscle in SMA pathogenesis. The SMA-miRs are likely actively released in the blood flow; their function and target cells require to be elucidated. The accuracy of the SMA-score needs to be verified in replicative studies: If confirmed, its use could be crucial for the routine prognostic assessment, also in presymptomatic patients.
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- 2021
9. Simultaneous onset of mycobacterium kansasii pulmonary infection and systemic lupus erythematosus: A case report
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Bruno, D., Tanti, G., Cingolani, A., Ria, F., Gremese, E., Mirone, L., Bruno D., Tanti G., Cingolani A. (ORCID:0000-0002-3793-2755), Ria F. (ORCID:0000-0002-8444-0307), Gremese E. (ORCID:0000-0002-2248-1058), Mirone L. (ORCID:0000-0001-5820-5533), Bruno, D., Tanti, G., Cingolani, A., Ria, F., Gremese, E., Mirone, L., Bruno D., Tanti G., Cingolani A. (ORCID:0000-0002-3793-2755), Ria F. (ORCID:0000-0002-8444-0307), Gremese E. (ORCID:0000-0002-2248-1058), and Mirone L. (ORCID:0000-0001-5820-5533)
- Abstract
Patient: Female, 19-year-old Final Diagnosis: Systemic lupus erythematosus Symptoms: Cough • Fever • malaise and fatigue • polyarthralgia • skin rash Medication: — Clinical Procedure: — Specialty: Rheumatology Objective: Background: Case Report: Conclusions: Unknown ethiology Systemic lupus erythematosus (SLE) is a systemic autoimmune disease resulting from dysregulation of the immune response. In genetically predisposed subjects, infections reputedly trigger an immune activation leading to autoimmunity and overt autoimmune diseases such as SLE. We report the case of a 19-year-old woman who presented to our hospital reporting high-grade fever, dry cough, and polyarthralgia despite a course of empiric antibiotic and steroid therapy administered by her general practi-tioner (GP). On physical examination, she had a malar rash, a palpable erythematous maculopapular non-itchy rash over the limbs and trunk, and mild polyarthritis. A contrast computed tomography (CT) scan of the chest showed a pulmonary right upper-lobe consolidation with air bronchogram and multiple necrotizing conglom-erate mediastinal lymph nodes. Culturing of collected samples from endobronchial ultrasound-guided trans-bronchial needle aspiration (EBUS-TBNA) of the mediastinal lymph node revealed growth of Mycobacterium kansasii. Antinuclear antibodies (ANA) and lupus anticoagulant (LAC) were positive. A diagnosis of M. kansasii infection associated with SLE was made. She was started on anti-mycobacterial and hydroxychloroquine therapy and entered into a joint rheumatological and infectious disease follow-up. Six months later, a CT scan with positron emission tomography (PET) showed a significant reduction in size of the basal right upper-lobe consolidation and hypermetabolic activity in multiple pulmonary areas and mediastinal lymph nodes. ANA and LAC tests were repeated and remained positive. The decision was made to continue the ongoing therapy course for 1 year in total. Clinical and experimental s
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- 2021
10. Restricted T-Cell Repertoire in the Epicardial Adipose Tissue of Non-ST Segment Elevation Myocardial Infarction Patients
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Pedicino, Daniela, Severino, Anna, Di Sante, Gabriele, De Rosa, Maria Cristina, Pirolli, Davide, Vinci, Ramona, Pazzano, V., Giglio, A. F., Trotta, F., Russo, G., Ruggio, A., Pisano, Eugenia, D'Aiello, Alessia, Canonico, Francesco, Ciampi, P., Cianflone, D., Cianfanelli, L., Grimaldi, Maria Chiara, Filomia, Simone, Luciani, Nicola, Glieca, Franco, Bruno, Piergiorgio, Massetti, Massimo, Ria, Francesco, Crea, Filippo, Liuzzo, Giovanna, Pedicino D., Severino A., Di Sante G. (ORCID:0000-0001-6608-3388), De Rosa M. C., Pirolli D. (ORCID:0000-0003-2303-2577), Vinci R., Pisano E., d'Aiello A., Canonico F. (ORCID:0000-0001-6936-4548), Grimaldi M. C., Filomia S., Luciani N. (ORCID:0000-0002-9407-0303), Glieca F. (ORCID:0000-0003-3645-7152), Bruno P. (ORCID:0000-0002-1075-5808), Massetti M. (ORCID:0000-0002-7100-8478), Ria F. (ORCID:0000-0002-8444-0307), Crea F. (ORCID:0000-0001-9404-8846), Liuzzo G. (ORCID:0000-0002-5714-0907), Pedicino, Daniela, Severino, Anna, Di Sante, Gabriele, De Rosa, Maria Cristina, Pirolli, Davide, Vinci, Ramona, Pazzano, V., Giglio, A. F., Trotta, F., Russo, G., Ruggio, A., Pisano, Eugenia, D'Aiello, Alessia, Canonico, Francesco, Ciampi, P., Cianflone, D., Cianfanelli, L., Grimaldi, Maria Chiara, Filomia, Simone, Luciani, Nicola, Glieca, Franco, Bruno, Piergiorgio, Massetti, Massimo, Ria, Francesco, Crea, Filippo, Liuzzo, Giovanna, Pedicino D., Severino A., Di Sante G. (ORCID:0000-0001-6608-3388), De Rosa M. C., Pirolli D. (ORCID:0000-0003-2303-2577), Vinci R., Pisano E., d'Aiello A., Canonico F. (ORCID:0000-0001-6936-4548), Grimaldi M. C., Filomia S., Luciani N. (ORCID:0000-0002-9407-0303), Glieca F. (ORCID:0000-0003-3645-7152), Bruno P. (ORCID:0000-0002-1075-5808), Massetti M. (ORCID:0000-0002-7100-8478), Ria F. (ORCID:0000-0002-8444-0307), Crea F. (ORCID:0000-0001-9404-8846), and Liuzzo G. (ORCID:0000-0002-5714-0907)
- Abstract
Aims: Human epicardial adipose tissue, a dynamic source of multiple bioactive factors, holds a close functional and anatomic relationship with the epicardial coronary arteries and communicates with the coronary artery wall through paracrine and vasocrine secretions. We explored the hypothesis that T-cell recruitment into epicardial adipose tissue (EAT) in patients with non-ST segment elevation myocardial infarction (NSTEMI) could be part of a specific antigen-driven response implicated in acute coronary syndrome onset and progression. Methods and Results: We enrolled 32 NSTEMI patients and 34 chronic coronary syndrome (CCS) patients undergoing coronary artery bypass grafting (CABG) and 12 mitral valve disease (MVD) patients undergoing surgery. We performed EAT proteome profiling on pooled specimens from three NSTEMI and three CCS patients. We performed T-cell receptor (TCR) spectratyping and CDR3 sequencing in EAT and peripheral blood mononuclear cells of 29 NSTEMI, 31 CCS, and 12 MVD patients. We then used computational modeling studies to predict interactions of the TCR beta chain variable region (TRBV) and explore sequence alignments. The EAT proteome profiling displayed a higher content of pro-inflammatory molecules (CD31, CHI3L1, CRP, EMPRINN, ENG, IL-17, IL-33, MMP-9, MPO, NGAL, RBP-4, RETN, VDB) in NSTEMI as compared to CCS (P < 0.0001). CDR3-beta spectratyping showed a TRBV21 enrichment in EAT of NSTEMI (12/29 patients; 41%) as compared with CCS (1/31 patients; 3%) and MVD (none) (ANOVA for trend P < 0.001). Of note, 11/12 (92%) NSTEMI patients with TRBV21 perturbation were at their first manifestation of ACS. Four patients with the first event shared a distinctive TRBV21-CDR3 sequence of 178 bp length and 2/4 were carriers of the human leukocyte antigen (HLA)-A*03:01 allele. A 3D analysis predicted the most likely epitope able to bind HLA-A3*01 and interact with the TRBV21-CDR3 sequence of 178 bp length, while the alignment results were consistent wit
- Published
- 2022
11. CSF CXCL13 and Chitinase 3-like-1 Levels Predict Disease Course in Relapsing Multiple Sclerosis
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Lucchini, Matteo, De Arcangelis, V., Piro, G., Nociti, Viviana, Bianco, Assunta, De Fino, Chiara, Di Sante, Gabriele, Ria, Francesco, Calabresi, Paolo, Mirabella, Massimiliano, Lucchini M. (ORCID:0000-0002-0447-2297), Nociti V. (ORCID:0000-0002-4607-3948), Bianco A., De Fino C., Di Sante G. (ORCID:0000-0001-6608-3388), Ria F. (ORCID:0000-0002-8444-0307), Calabresi P. (ORCID:0000-0003-0326-5509), Mirabella M. (ORCID:0000-0002-7783-114X), Lucchini, Matteo, De Arcangelis, V., Piro, G., Nociti, Viviana, Bianco, Assunta, De Fino, Chiara, Di Sante, Gabriele, Ria, Francesco, Calabresi, Paolo, Mirabella, Massimiliano, Lucchini M. (ORCID:0000-0002-0447-2297), Nociti V. (ORCID:0000-0002-4607-3948), Bianco A., De Fino C., Di Sante G. (ORCID:0000-0001-6608-3388), Ria F. (ORCID:0000-0002-8444-0307), Calabresi P. (ORCID:0000-0003-0326-5509), and Mirabella M. (ORCID:0000-0002-7783-114X)
- Abstract
Several biomarkers from multiple sclerosis (MS) patients' biological fluids have been considered to support diagnosis, predict disease course, and evaluate treatment response. In this study, we assessed the CSF concentration of selected molecules implicated in the MS pathological process. To investigate the diagnostic and prognostic significance of CSF concentration of target candidate biomarkers in both relapsing (RMS, n = 107) and progressive (PMS, n = 18) MS patients and in other inflammatory (OIND, n = 10) and non-inflammatory (ONIND, n = 15) neurological disorders. We measured the CSF concentration of APRIL, BAFF, CHI3L1, CCL-2, CXCL-8, CXCL-10, CXCL-12, CXCL-13 through a Luminex Assay. MS patients were prospectively evaluated, and clinical and radiological activity were recorded. CHI3L1 and CXCL13 CSF levels were significantly higher in both MS groups compared to control groups, while CCL2, BAFF, and APRIL concentrations were lower in RMS patients compared to PMS and OIND. Considering RMS patients with a single demyelinating event, higher concentrations of CHI3L1, CXCL10, CXCL12, and CXCL13 were recorded in patients who converted to clinically defined MS(CDMS). RMS patients in the CXCL13 and CHI3L1 high concentration group had a significantly higher risk of relapse (HR 12.61 and 4.57), MRI activity (HR 7.04 and 2.46), and of any evidence of disease activity (HR 12.13 and 2.90) during follow-up. CSF CXCL13 and CHI3L1 levels represent very good prognostic biomarkers in RMS patients, and therefore can be helpful in the treatment choice. Higher CSF concentrations of neuro-inflammatory biomarkers were associated with a higher risk of conversion to CDMS in patients with a first clinical demyelinating event. Differential CSF BAFF and APRIL levels between RMS and PMS suggest a different modulation of B-cells pathways in the different phases of the disease.
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- 2022
12. Recovering or Persisting: The Immunopathological Features of SARS-CoV-2 Infection in Children
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Buonsenso, Danilo, Valentini, Piero, De Rose, Cristina, Tredicine, Maria, Pereyra Boza, Maria Del Carmen, Camponeschi, C., Morello, Rosa, Zampino, Giuseppe, Brooks, A. E. S., Rende, M., Ria, Francesco, Sanguinetti, Maurizio, Delogu, Giovanni, Sali, Michela, Di Sante, Gabriele, Buonsenso D., Valentini P. (ORCID:0000-0001-6095-9510), De Rose C., Tredicine M., Pereyra Boza M. D. C., Morello R., Zampino G. (ORCID:0000-0003-3865-3253), Ria F. (ORCID:0000-0002-8444-0307), Sanguinetti M. (ORCID:0000-0002-9780-7059), Delogu G. (ORCID:0000-0003-0182-8267), Sali M. (ORCID:0000-0003-3609-2990), Di Sante G. (ORCID:0000-0001-6608-3388), Buonsenso, Danilo, Valentini, Piero, De Rose, Cristina, Tredicine, Maria, Pereyra Boza, Maria Del Carmen, Camponeschi, C., Morello, Rosa, Zampino, Giuseppe, Brooks, A. E. S., Rende, M., Ria, Francesco, Sanguinetti, Maurizio, Delogu, Giovanni, Sali, Michela, Di Sante, Gabriele, Buonsenso D., Valentini P. (ORCID:0000-0001-6095-9510), De Rose C., Tredicine M., Pereyra Boza M. D. C., Morello R., Zampino G. (ORCID:0000-0003-3865-3253), Ria F. (ORCID:0000-0002-8444-0307), Sanguinetti M. (ORCID:0000-0002-9780-7059), Delogu G. (ORCID:0000-0003-0182-8267), Sali M. (ORCID:0000-0003-3609-2990), and Di Sante G. (ORCID:0000-0001-6608-3388)
- Abstract
Background. The profile of cellular immunological responses of children across the spectrum of COVID-19, ranging from acute SARS-CoV-2 infection to full recovery or Long COVID, has not yet been fully investigated. Methods. We examined and compared cytokines in sera and cell subsets in peripheral blood mononuclear cells (B and regulatory T lymphocytes) collected from four distinct groups of children, distributed as follows: younger than 18 years of age with either acute SARS-CoV-2 infection (n = 49); fully recovered from COVID-19 (n = 32); with persistent symptoms (Long COVID, n = 51); and healthy controls (n = 9). Results. In the later stages after SARS-CoV-2 infection, the cohorts of children, both with recovered and persistent symptoms, showed skewed T and B subsets, with remarkable differences when compared with children at the onset of the infection and with controls. The frequencies of IgD+CD27− naïve B cells, IgD+IgM+ and CD27−IgM+CD38dim B cells were higher in children with recent infection than in those with an older history of disease (p < 0.0001 for all); similarly, the total and natural Tregs compartments were more represented in children at onset when compared with Long COVID (p < 0.0001 and p = 0.0005, respectively). Despite the heterogeneity, partially due to age, sex and infection incidence, the susceptibility of certain children to develop persistent symptoms after infection appeared to be associated with the imbalance of the adaptive immune response. Following up and comparing recovered versus Long COVID patients, we analyzed the role of circulating naïve and switched B and regulatory T lymphocytes in counteracting the evolution of the symptomatology emerged, finding an interesting correlation between the amount and ability to reconstitute the natural Tregs component with the persistence of symptoms (linear regression, p = 0.0026). Conclusions. In this study, we suggest that children affected by Long COVID may have a compromised ability to s
- Published
- 2022
13. Fighting autoinflammation in FIRES: The role of interleukins and early immunomodulation
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Perulli, Marco, Cicala, Gianpaolo, Turrini, Ida, Musto, Elisa, Quintiliani, Michela, Gambardella, Maria Luigia, Pulitano', Silvia Maria, Bompard, S., Staccioli, S., Carmillo, L., Di Sante, Gabriele, Ria, Francesco, Veredice, Chiara, Contaldo, Ilaria, Battaglia, Domenica Immacolata, Perulli M., Cicala G., Turrini I., Musto E., Quintiliani M., Gambardella M. L., Pulitano S. M. (ORCID:0000-0002-8496-379X), Di Sante G. (ORCID:0000-0001-6608-3388), Ria F. (ORCID:0000-0002-8444-0307), Veredice C., Contaldo I., Battaglia D. (ORCID:0000-0003-0491-4021), Perulli, Marco, Cicala, Gianpaolo, Turrini, Ida, Musto, Elisa, Quintiliani, Michela, Gambardella, Maria Luigia, Pulitano', Silvia Maria, Bompard, S., Staccioli, S., Carmillo, L., Di Sante, Gabriele, Ria, Francesco, Veredice, Chiara, Contaldo, Ilaria, Battaglia, Domenica Immacolata, Perulli M., Cicala G., Turrini I., Musto E., Quintiliani M., Gambardella M. L., Pulitano S. M. (ORCID:0000-0002-8496-379X), Di Sante G. (ORCID:0000-0001-6608-3388), Ria F. (ORCID:0000-0002-8444-0307), Veredice C., Contaldo I., and Battaglia D. (ORCID:0000-0003-0491-4021)
- Abstract
Febrile infection-related epilepsy syndrome (FIRES) is a challenging condition with unfavorable outcome in most cases. Preliminary evidence suggests that some interleukins, in particular IL-1 Receptor Antagonist (IL-1RA), could be elevated due to a functional deficiency of anti-inflammatory pathways. Therefore, treatment strategies acting on innate immunity could represent a targeted treatment. We describe the case of an 11-year-old child with super-refractory status epilepticus (SE), lasting more than two months. After being treated aggressively with antiseizure medications, anesthetics and empiric treatment for autoimmune encephalitis without success, she responded to anakinra and ketogenic diet. Escalation of the therapy was supported by the finding of a very high serum level of IL-1RA. This immunomodulatory approach allowed to discharge the child from intensive care 48 days after the SE onset. After more than one year follow-up the patient has moderate intellectual disability but with good language skills; she is seizure free and without motor deficits. This case suggests that serum IL-1RA serum levels may help to support treatment escalation. Moreover, anakinra and ketogenic diet represent encouraging immunomodulatory strategies which deserve further studies and could potentially have a synergistic effect. Finally, structured neuropsychological testing is an important outcome measure that will help to define the effectiveness of different treatment strategies.
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- 2022
14. Determination of the Expressed T cell Repertoire: The Outcome of Competition at the Levels of Antigen Presentation and T cell Receptor Recognition
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Maverakis, E., Beech, J., Deng, H., Schneider, C., Van Den Elzen, P., Madakamutil, T., Ria, F., Moudgil, K., Kumar, V., Campagnoni, A., Sercarz, E. E., Eibl, Martha, editor, Mayr, W. R., editor, and Thorbecke, G. J., editor
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- 2002
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15. Ablative robotic radiosurgery for inoperable patients with stage IA–IB non small cell lung cancer: 102P
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Zanetti, Bossi I., Scanagatta, P., Bianchi, L. C., Bergantin, A., Martinotti, A. S., Redaelli, I., Ria, F., Vai, A., Invernizzi, M., and Beltramo, G.
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- 2016
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16. Immune regulatory and neuroprotective properties of preimplantation factor: From newborn to adult
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Barnea, E. R., Almogi-Hazan, O., Or, R., Mueller, M., Ria, F., Weiss, L., and Paidas, M. J.
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- 2015
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17. HLA-DRB1 haplotype associates with selection of lipid transfer protein variants as targets of food allergy
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Nucera, E, Valentini, M, Mezzacappa, S, Migliara, G, Chini, R, Rizzi, A, Aruanno, A, Ria, F, Nucera, E (ORCID:0000-0002-0565-7680), Rizzi, A (ORCID:0000-0002-6795-746X), Ria, F (ORCID:0000-0002-8444-0307), Nucera, E, Valentini, M, Mezzacappa, S, Migliara, G, Chini, R, Rizzi, A, Aruanno, A, Ria, F, Nucera, E (ORCID:0000-0002-0565-7680), Rizzi, A (ORCID:0000-0002-6795-746X), and Ria, F (ORCID:0000-0002-8444-0307)
- Abstract
N/A
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- 2019
18. Study of the effects of Lemna minor extracts on human immune cell populations
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Catelani Cardoso, C., Miraldi, E., Ceccarini, M. R., Naureen, Z., Baini, G., Manara, E., Anpilogov, K., Camilleri, G., Dhuli, K., Paolacci, S., Ria, Francesco, Di Sante, Gabriele, Camponeschi, C., Tredicine, Maria, Zanlari, A., Chiurazzi, Pietro, Beccari, T., Bertelli, M., Ria F. (ORCID:0000-0002-8444-0307), Di Sante G. (ORCID:0000-0001-6608-3388), Tredicine M., Chiurazzi P. (ORCID:0000-0001-5104-1521), Catelani Cardoso, C., Miraldi, E., Ceccarini, M. R., Naureen, Z., Baini, G., Manara, E., Anpilogov, K., Camilleri, G., Dhuli, K., Paolacci, S., Ria, Francesco, Di Sante, Gabriele, Camponeschi, C., Tredicine, Maria, Zanlari, A., Chiurazzi, Pietro, Beccari, T., Bertelli, M., Ria F. (ORCID:0000-0002-8444-0307), Di Sante G. (ORCID:0000-0001-6608-3388), Tredicine M., and Chiurazzi P. (ORCID:0000-0001-5104-1521)
- Abstract
OBJECTIVE: Lemna minor is a plant with a huge repertoire of secondary metabolites. The literature indicates that extracts of Lemna minor have antioxidant, antiradical, immunomodulatory and anti-inflammatory properties. The objective of the present study was to find a suitable technique to extract active compounds from this plant and verify whether these extracts have immunomodulatory activity. MATERIALS AND METHODS: We grew L. minor on a standard medium with Gamborg B5 and vitamins. We extracted compounds from the plant by maceration and decoction. The phytochemical profile of the extracts was characterized by chromatography, spectrophotometry, and spectroscopy. The extracts were tested on cultures of mononuclear cells from four human subjects. These cells were pulsed with carboxyfluorescein succinimidyl ester, grown in triplicate in standard culture medium without (control) and with increasing concentrations of Lemna extracts. Flow cytometry was used to evaluate cell death and proliferation of the total mononuclear cell population and of CD4+, CD8+, B cell and monocyte populations. RESULTS: The Lemna extracts were not cytotoxic and did not cause cell necrosis or apoptosis in immune cells. At low concentrations, they induced very limited proliferation of CD4+ cells within 48 hours. At high concentrations, they induced proliferation of CD8+ cells and B lymphocytes within 48 hours. CONCLUSIONS: Unfortunately, we failed to confirm any immunomodulatory activity of Lemna extracts. Growth and death rates of human immune cells were not significantly affected by adding Lemna extracts to the culture medium.
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- 2021
19. S100B protein as a therapeutic target in multiple sclerosis: The S100B inhibitor arundic acid protects from chronic experimental autoimmune encephalomyelitis
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Camponeschi, C., De Carluccio, M., Amadio, S., Clementi, Maria Elisabetta, Sampaolese, B., Volonte, C., Tredicine, Maria, Spica, V. R., Di Liddo, R., Ria, Francesco, Michetti, Fabrizio, Di Sante, Gabriele, Clementi M. E., Tredicine M., Ria F. (ORCID:0000-0002-8444-0307), Michetti F. (ORCID:0000-0003-2546-0532), Di Sante G. (ORCID:0000-0001-6608-3388), Camponeschi, C., De Carluccio, M., Amadio, S., Clementi, Maria Elisabetta, Sampaolese, B., Volonte, C., Tredicine, Maria, Spica, V. R., Di Liddo, R., Ria, Francesco, Michetti, Fabrizio, Di Sante, Gabriele, Clementi M. E., Tredicine M., Ria F. (ORCID:0000-0002-8444-0307), Michetti F. (ORCID:0000-0003-2546-0532), and Di Sante G. (ORCID:0000-0001-6608-3388)
- Abstract
S100B is an astrocytic protein behaving at high concentration as a damage-associated molecular pattern molecule. A direct correlation between the increased amount of S100B and inflammatory processes has been demonstrated, and in particular, the inhibitor of S100B activity pentamidine has been shown to ameliorate clinical scores and neuropathologic-biomolecular parameters in the relapsing-remitting experimental autoimmune encephalomyelitis mouse model of multiple sclerosis. This study investigates the effect of arundic acid (AA), a known inhibitor of astrocytic S100B synthesis, in the chronic experimental autoimmune encephalomyelitis, which is another mouse model of multiple sclerosis usually studied. By the daily evaluation of clinical scores and neuropathologic-molecular analysis performed in the spinal cord, we observed that the AA-treated group showed lower severity compared to the vehicle-treated mice, particularly in the early phase of disease onset. We also observed a significant reduction of astrocytosis, demyelination, immune infiltrates, proinflammatory cytokines expression and enzymatic oxidative reactivity in the AA-treated group. Overall, our results reinforce the involvement of S100B in the development of animal models of multiple sclerosis and propose AA targeting the S100B protein as a focused potential drug to be considered for multiple sclerosis treatment.
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- 2021
20. SMA-miRs (MiR-181a- 5p, -324-5p, and -451a) are overexpressed in spinal muscular atrophy skeletal muscle and serum samples
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Abiusi, Emanuela, Infante, P., Cagnoli, C., Severini, L. L., Pane, Marika, Coratti, Giorgia, Pera, Maria Carmela, D'Amico, Adele, Diano, Federica, Novelli, Agnese, Spartano, Serena, Fiori, Simona, Baranello, Giovanni, Moroni, I., Mora, M., Pasanisi, M. B., Pocino, Krizia, Le Pera, L., D'Amico, D., Travaglini, L., Ria, Francesco, Bruno, C., Locatelli, D., Bertini, Enrico Silvio, Morandi, L. O., Mercuri, Eugenio Maria, Di Marcotullio, L., Tiziano, Francesco Danilo, Abiusi E. (ORCID:0000-0001-9028-012X), Pane M. (ORCID:0000-0002-4851-6124), Coratti G. (ORCID:0000-0001-6666-5628), Pera M. C. (ORCID:0000-0001-6777-1721), D'amico A., Diano F., Novelli A., Spartano S., Fiori S., Baranello G., Pocino K. (ORCID:0000-0003-2456-5308), Ria F. (ORCID:0000-0002-8444-0307), Bertini E. S., Mercuri E. (ORCID:0000-0002-9851-5365), Tiziano F. D. (ORCID:0000-0002-5545-6158), Abiusi, Emanuela, Infante, P., Cagnoli, C., Severini, L. L., Pane, Marika, Coratti, Giorgia, Pera, Maria Carmela, D'Amico, Adele, Diano, Federica, Novelli, Agnese, Spartano, Serena, Fiori, Simona, Baranello, Giovanni, Moroni, I., Mora, M., Pasanisi, M. B., Pocino, Krizia, Le Pera, L., D'Amico, D., Travaglini, L., Ria, Francesco, Bruno, C., Locatelli, D., Bertini, Enrico Silvio, Morandi, L. O., Mercuri, Eugenio Maria, Di Marcotullio, L., Tiziano, Francesco Danilo, Abiusi E. (ORCID:0000-0001-9028-012X), Pane M. (ORCID:0000-0002-4851-6124), Coratti G. (ORCID:0000-0001-6666-5628), Pera M. C. (ORCID:0000-0001-6777-1721), D'amico A., Diano F., Novelli A., Spartano S., Fiori S., Baranello G., Pocino K. (ORCID:0000-0003-2456-5308), Ria F. (ORCID:0000-0002-8444-0307), Bertini E. S., Mercuri E. (ORCID:0000-0002-9851-5365), and Tiziano F. D. (ORCID:0000-0002-5545-6158)
- Abstract
Background: Spinal muscular atrophy (SMA) is a neuromuscular disorder characterized by the degeneration of the second motor neuron. The phenotype ranges from very severe to very mild forms. All patients have the homozygous loss of the SMN1 gene and a variable number of SMN2 (generally 2–4 copies), inversely related to the severity. The amazing results of the available treatments have made compelling the need of prognostic biomarkers to predict the progression trajectories of patients. Besides the SMN2 products, few other biomarkers have been evaluated so far, including some miRs. Methods: We performed whole miRNome analysis of muscle samples of patients and controls (14 biopsies and 9 cultures). The levels of muscle differentially expressed miRs were evaluated in serum samples (51 patients and 37 controls) and integrated with SMN2 copies, SMN2 full-length transcript levels in blood and age (SMA-score). Results: Over 100 miRs were differentially expressed in SMA muscle; 3 of them (hsa-miR-181a-5p, -324-5p, -451a; SMA-miRs) were significantly upregulated in the serum of patients. The severity predicted by the SMA-score was related to that of the clinical classification at a correlation coefficient of 0.87 (p<10-5). Conclusions: MiRNome analyses suggest the primary involvement of skeletal muscle in SMA pathogenesis. The SMA-miRs are likely actively released in the blood flow; their function and target cells require to be elucidated. The accuracy of the SMA-score needs to be verified in replicative studies: If confirmed, its use could be crucial for the routine prognostic assessment, also in presymptomatic patients.
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- 2021
21. Past and future of the molecular characterization of the T cell repertoire: Some highlights of eli sercarz’s contributions
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Di Sante, Gabriele, Tredicine, Maria, Rolla, S., Di Pino, Antonella, Ria, Francesco, Di Sante G. (ORCID:0000-0001-6608-3388), Tredicine M., Di Pino A., Ria F. (ORCID:0000-0002-8444-0307), Di Sante, Gabriele, Tredicine, Maria, Rolla, S., Di Pino, Antonella, Ria, Francesco, Di Sante G. (ORCID:0000-0001-6608-3388), Tredicine M., Di Pino A., and Ria F. (ORCID:0000-0002-8444-0307)
- Abstract
The contribution of Eli E. Sercarz to immunology and immunopathology has been remarkable and achieved many milestones in the understanding of the processes of the mechanisms fine-tuning immune responses. A part of his work was dedicated to the study of the deep complexity of the lymphocyte T cell repertoire and its importance during the physiologic development and disease, such as clonal heterogeneity of T cell responses. Starting from these studies, under his mentoring, we had the opportunity to implement the spectratyping method and apply it to human and experimental autoimmune diseases, obtaining intriguing results. The open question of this brief review is the possible role of this fine and complex technique, the immunoscope analysis, in the era of the big data and omics.
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- 2020
22. Immune response at birth, long-term immune memory and 2 years follow-up after in-utero anti-HBV DNA immunization
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Fazio, VM, Ria, F, Franco, E, Rosati, P, Cannelli, G, Signori, E, Parrella, P, Zaratti, L, Iannace, E, Monego, G, Blogna, S, Fioretti, D, Iurescia, S, Filippetti, R, and Rinaldi, M
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- 2004
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23. House dust mite allergy and shrimp allergy: a complex interaction
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Celi, G., primary, Brusca, I., additional, Scala, E., additional, Villalta, D., additional, Pastorello, E., additional, Farioli, L., additional, Cortellini, G., additional, Deleonardi, G., additional, Galati, P., additional, Losappio, L., additional, Manzotti, G., additional, Pirovano, B., additional, Muratore, L., additional, Murzilli, F., additional, Cucinelli, F., additional, Musarra, A., additional, Cilia, M., additional, Nucera, E., additional, Aruanno, A., additional, Ria, F., additional, Patria, M.F., additional, Varin, E., additional, Polillo, B.R., additional, Sargentini, V., additional, Quercia, O., additional, Uasuf, C.G., additional, Zampogna, S., additional, Carollo, M., additional, Graci, S., additional, and Asero, R., additional
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- 2020
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24. Sinningia flammea Chautems & Valqu��ria F. Dutra & Fontana & Peixoto & Perret & Rossini 2019, spec. nova
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Chautems, Alain, Valqu��ria F. Dutra, Fontana, Andr�� P., Peixoto, Mauro, Perret, Mathieu, and Rossini, Josiene
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Tracheophyta ,Magnoliopsida ,Sinningia ,Sinningia flammea ,Biodiversity ,Gesneriaceae ,Plantae ,Taxonomy ,Lamiales - Abstract
Sinningia flammea Chautems & Rossini, spec. nova (Fig. 2A, 3). Holotypus: BRAZIL. Esp��rito Santo: Itagua��u, Cachoei- r��o, propriedade Sr. Hil��rio Lopes, trilha da cachoeira, 8.IX.2006, fl., R.C. Britto et al. 134 (MBML-39758!). This species resembles Sinningia aghensis Chautems by the habit, the leaves nearly whorled and the long ascending peduncles, but differs by having smaller leaf blades that are vinaceous abaxially and by the narrow tubular bright orange corollas with a greenish-yellow throat (vs. leaves green abaxially and wide tubular funnel-shape and purple corollas, with a darker purple and white marbled throat). Herb rupicolous, arising from perennial tuber, 2���9 �� 3���10 cm in diam. Stems erect, 8���30 cm tall, usually unbranched, reddish to vinaceous with some green streaks, villose, trichomes 3���4 mm long. Leaves usually 2 pairs, decussate, isophyllous, condensed in an apparent whorl of 4 toward the apex of the stem, petiole 0,3��� 1 cm long, blade ovate to obovate 2.2���9 �� 1.6���6.7 cm, dark green and pubescent on adaxial face, vinaceous and incanoustomentose abaxially, base obtuse, apex obtuse, margin crenatedenticulate, 7���9 pairs of veins, vinaceous abaxially. Inflorescence 1���2 pair(s) of ascending peduncles, in the axils of upper leafs or small bracts below the leafs, 10���27 cm long, vinaceous with greenish dots, villose, each peduncle carrying at their apex 4���12 flowers organized in pair-flowered cymes. Flowers borne on erect to horizontal pedicels, 1.3���4.7 cm long, vinaceous, villose. Calyx campanulate, sepals fused at base for 3 mm, green with reddish apex, 9 �� 3 mm, triangular to lanceolate, pubes- cent with glandular trichomes. Corolla tubular, 4.2���4.5 cm long, outside dark vinaceous at young buds stage, brightly orange with touch of yellow at maturity, pubescent with longer eglandular and shorter glandular trichomes, tube at the very base enlarged forming two dorsal bulges that are the nectary chambers, c. 7 mm diam., then, briefly constricted to around 3���4 mm in diam., widening progressively to about 8 mm in diam., throat greenish yellow, lobes equal, patent, internally greenish yellow at base, orange at the apex with yellow veins. Stamens 4, included, filaments 3.9���4.2 cm long, white or yellowish, puberulous, anthers 3 �� 2 mm, coherent by their apex and side, star-shaped, pollen white; nectary formed by five separate glands of 1���2 �� 1 mm; ovary conical, 5���7 mm long, whitish, puberulous, style 4.5���4.8 cm long, white, puberulous, barely exserted at maturity, stigma stomatomorphic. Fruit a conical capsule, beaked at the apex, fully dehiscent, 8���10 �� 4���5 mm, seeds fusiform to prolate, dark brown, 0.5���0.6 mm. Etymology. ��� The name refers to the bright and vivid yellow-orange color of the corolla that evokes fire flames. Distribution and ecology. ��� This species is endemic to the eastern part of Esp��rito Santo State (Fig. 1). It has only been encountered on inselbergs above 700 m alt. in the Municipalities of Itagua��u and Colatina. Scattered populations have been found growing on sun exposed and steep granitic rock, among clumps of large Bromeliaceae and Velloziaceae. Phenology. ��� Flowers were observed between July and September. Mature fruits were registered on cultivated material around November-December. Conservation status. ��� The new species has been observed so far in only two localities representing two locations. None of them are part of the protected area network. Populations are composed of a few scattered individuals. Threats in those locations are granite extraction from the inselbergs and extension of monoculture of coffee or Eucalyptus L���H��r. in the immediate surroundings. With an EOO Sinningia flammea is assigned a preliminary assessment as ���Endangered��� [EN B1ab(iii)] using the IUCN Red List (IUCN, 2012). Notes. ��� The new species is morphologically related to S. aghensis, sharing similarities in the whorled phyllotaxis, the leaf blade shape and the very long peduncles. Nevertheless, it differs by having much smaller leaf blades and narrow tubular bright orange corollas (vs tubular-campanulate dark purple corollas). Although flowers arise from long peduncles above a leafy stem and not directly from the tuber, the long tubular corollas resemble S. helioana Chautems & Rossini, but color and size differ (bright orange tube 4.2��� 4.5 cm long with greenish hues in throat vs tube red 2.5���3 cm long with throat cream). Preliminary phylogenetic data place the new species in close relationship with the two above mentioned taxa within the clade ��� Corytholoma ��� (PERRET et al. 2003, 2007). Material of this species was introduced in cultivation under the provisional name Sinningia sp. ���Itaguassu���. Paratypus. ��� BRAZIL. Esp��rito Santo: Colatina, Itapina, morro do Maquiji, C��rrego Maquiji, Fazenda Pedra Grande, 27.VII.2009, fl., A.P. Fontana & L. Menini Neto 6076 (MBML-47808)., Published as part of Chautems, Alain, Valqu��ria F. Dutra,, Fontana, Andr�� P., Peixoto, Mauro, Perret, Mathieu & Rossini, Josiene, 2019, Three new species of Sinningia (Gesneriaceae) endemic to Esp��rito Santo, Brazil, pp. 33-42 in Candollea 74 (1) on pages 34-37, DOI: 10.15553/c2019v741a5, http://zenodo.org/record/3404226, {"references":["IUCN (2012). IUCN Red List Categories and Criteria: Version 3.1 ed. 2. IUCN Species Survival Commission, IUCN, Gland & Cambridge.","PERRET M., A. CHAUTEMS, R. SPICHIGER, G. KITE & V. SAVOLAINEN (2003). Systematics and evolution of tribe Sinningieae (Gesneriaceae): Evidence from phylogenetic analyses of six plastid DNA regions and nuclear ncpGS. Am. J. Bot. 90: 445 - 460."]}
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- 2019
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25. Sinningia stapelioides Chautems & M. Peixoto 2019, spec. nova
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Chautems, Alain, Valqu��ria F. Dutra, Fontana, Andr�� P., Peixoto, Mauro, Perret, Mathieu, and Rossini, Josiene
- Subjects
Tracheophyta ,Magnoliopsida ,Sinningia stapelioides ,Sinningia ,Biodiversity ,Gesneriaceae ,Plantae ,Taxonomy ,Lamiales - Abstract
Sinningia stapelioides Chautems & M. Peixoto, spec. nova (Fig. 2D, 5). Holotypus: [BRAZIL. Esp��rito Santo]: cult. in CJBG under Acc. n�� AC-3518 originating from Pancas, Pedra da Agulha, 17.I.2012, fl., A. Chautems 555 (VIES!; iso-: G spirit!). Sinningia stapelioides resembles S. defoliata (Malme) Chautems, S. helioana Chautems & Rossini and S. tuberosa (Mart.) H.E. Moore in having inflorescences and leaves arising separately and successively from the tuber with rarely more than one leaf blade produced by a petiole-like stem. It differs however by a pauciflorous inflorescence with distinctive flowers having a large (5���6 cm) tubular-campanulate corolla, dull red orange outside with a peculiar throat that is greenishcream with a dense network of vinaceous streaks that extends on the inner face of the lobes (vs long, up to 3���4 cm, tubular and bright red corollas). Herb, arising from perennial tuber, saxicolous; tuber spheroidal, 4���12 cm in diam., leaves and inflorescences produced separately and successively, 1- rarely 2-petiole-like stems, obliquely arising from the tuber upper surface, 4���12 cm long, 3���4 mm in diam., vinaceous, pubescent, blade attachment swollen abaxially, 1���2 pairs of linear-lanceolate bracts just below blade insertion. Leaves forming an angle of nearly 90�� with the petiole-like stem, usually reduced to one large blade at maturity (during first growing cycle from seed seedlings produce 2���3 pairs of opposite leaves, followed on subsequent growing cycles from tuber by a phase with a second and small leaf blade, 1���5 mm long, produced in opposite position), ovate (3���)9���24 (��� 36) �� (1���)4���11(��� 18) cm, apex acute-acuminate, base shortly attenuate to truncate, green above, green or reddish beneath, finely puberulous-velutinous, margin slightly crenate, 10���15 pairs of veins. Inflorescences organized in well-developed pairflowered cymes of 1���3 flowers borne on a peduncle, 5���8 cm long, 1���2 mm in diam., greenish to vinaceous, emerging from 1���2 points of the tuber upper surface, bracts linear, 1���2 mm long. Flowers nodding, borne on pedicels, 2���4 cm long, greenish to vinaceous, puberulous. Calyx campanulate, sepals fused at base for 2��� 3 mm, narrowly triangular, 13���15 �� 6��� 7 mm, wide at base, greenish to reddish, margin entire, puberulous. Corolla slightly oblique in the calyx, tubular, 5��� 6 cm long, nectary chamber composed of 5 swellings, green, 9���10 mm wide at base, tube enlarged then towards the middle reaching 16���20 mm in diam., vinaceous in bud, dull red orange outside (RHS color chart # 35 B-C) at maturity, puberulous with simple and glandular trichomes, lobes 9���10 �� 18���20 mm, throat cream to greenish towards bottom, lobes spreading with a network of vinaceous streaks and dots on inner face. Stamens 4, included, filaments ca. 50 mm, greenish, glabrous, anthers coherent, star-shaped, pollen cream; nectary formed of five glands, equals in size, greenish; ovary vinaceous, style included, 40��� 50 mm long, vinaceous, puberulent, stigma greenish. Fruit a capsule, subulate at the apex, dark brown at maturity, 14���18 �� 9���11 mm, seeds ellipsoid, 7���9 mm long. Etymology. ��� The specific epithet refers to the color pattern of the corolla that resembles flowers of some members of the genus Stapelia L. (Apocynaceae). Distribution and ecology. ��� Only known so far from the type locality in the region of the ���Pont��es Capixabas���, an area classified as National Monument around the small town of Pancas, in the northern part of the state of Esp��rito Santo, Brazil (Fig. 1). The area is famous for large rock inselbergs, some reaching several hundred meters in height. A few tubers were observed growing on a vertical side of a granite block measuring ca. 5 m in height in shady situation, not far from a forested fragment partially converted to cocoa trees cultivation, within a small farm. Phenology. ��� Flowers observed in August (in cultivation in Brazil) or December (in cultivation in Geneva) and mature fruits in October (in cultivation in Brazil). Conservation status. ��� Less than ten individuals were observed in a single population growing on a large granitic block within a fragment of humid forest, with the understory partly planted with cocoa trees. This single location lies within a farm at a few hundred meters from the farmer residence. Most of the land is already converted to tropical crops, like banana and coffee. This reduced plant population is then heavily threatened by any change in the surroundings, like tree felling or extension of any other tropical crop. With an EOO S. stapelioides is assigned a preliminary assessment as ���Critically Endangered��� [CR B2ab(iii)] using the IUCN Red List (IUCN, 2012). Notes. ��� This species generates leaves and inflorescences separately and successively on the tuber surface, following the tuber dormancy period during the dry season (May-September). This feature is also present in three other Sinningia species, i.e., S. defoliata (Malme) Chautems, S. helioana and S. tuberosa (Mart.) H. E. Moore. This separate and successive development of vegetative and fertile shoots could have evolved at least twice independently in the genus. Indeed, preliminary phylogenetic data place this new taxon in the clade Corytholoma, together with S. defoliata and S. helioana, whereas S. tuberosa belongs to clade Sinningia (PERRET et al. 2003; M. Perret, unpubl. data). Nevertheless, S. stapelioides produces large (5���6 cm) tubular-campanulate corollas with a peculiar throat and lobes coloration pattern that differ from the long (up to 3���4 cm) tubular and bright red corollas displayed by these three species. Live material of this species was first obtained from the late R. A. Kautsky (later established to have been originally collected in the type locality within Sr. Adriano Romais��� property). It was introduced in cultivation under the provisional name Sinningia sp. ���Pancas���. The only available material collected in the wild is a sterile gathering, as all individuals at the time of the collection were in a vegetative phase. This sample is designated as a paratype. Fertile material could only be observed at a different period on a plant cultivated in Geneva originating from the same locality. A flower was then collected and designated here as the holotype. Paratypus. ��� BRAZIL. Esp��rito Santo: Pancas, base da Pedra da Agulha, propri��t�� do Sr. Adriano Romais, 4. V.2012, ster., Perret, Chautems, Peixoto & Duarte 55 (VIES-026563)., Published as part of Chautems, Alain, Valqu��ria F. Dutra,, Fontana, Andr�� P., Peixoto, Mauro, Perret, Mathieu & Rossini, Josiene, 2019, Three new species of Sinningia (Gesneriaceae) endemic to Esp��rito Santo, Brazil, pp. 33-42 in Candollea 74 (1) on pages 39-41, DOI: 10.15553/c2019v741a5, http://zenodo.org/record/3404226, {"references":["IUCN (2012). IUCN Red List Categories and Criteria: Version 3.1 ed. 2. IUCN Species Survival Commission, IUCN, Gland & Cambridge.","PERRET M., A. CHAUTEMS, R. SPICHIGER, G. KITE & V. SAVOLAINEN (2003). Systematics and evolution of tribe Sinningieae (Gesneriaceae): Evidence from phylogenetic analyses of six plastid DNA regions and nuclear ncpGS. Am. J. Bot. 90: 445 - 460."]}
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- 2019
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26. House dust mite allergy and shrimp allergy: a complex interaction
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Celi, G, Brusca, I, Scala, E, Villalta, D, Pastorello, E, Farioli, L, Cortellini, G, Deleonardi, G, Galati, P, Losappio, L, Manzotti, G, Pirovano, B, Muratore, L, Murzilli, F, Cucinelli, F, Musarra, Teresa, Cilia, M, Nucera, Eleonora, Aruanno, A, Ria, Francesco, Patria, M F, Varin, E, Polillo, B R, Sargentini, V, Quercia, O, Uasuf, C G, Zampogna, S, Carollo, M, Graci, S, Asero, R, Musarra, A, Nucera, E (ORCID:0000-0002-0565-7680), Ria, F (ORCID:0000-0002-8444-0307), Celi, G, Brusca, I, Scala, E, Villalta, D, Pastorello, E, Farioli, L, Cortellini, G, Deleonardi, G, Galati, P, Losappio, L, Manzotti, G, Pirovano, B, Muratore, L, Murzilli, F, Cucinelli, F, Musarra, Teresa, Cilia, M, Nucera, Eleonora, Aruanno, A, Ria, Francesco, Patria, M F, Varin, E, Polillo, B R, Sargentini, V, Quercia, O, Uasuf, C G, Zampogna, S, Carollo, M, Graci, S, Asero, R, Musarra, A, Nucera, E (ORCID:0000-0002-0565-7680), and Ria, F (ORCID:0000-0002-8444-0307)
- Abstract
Summary:Background and Objective. Sensitization and allergy to shrimp among Italian house dust mite allergic patients are not well defined and were investigated in a large multicenter study. Methods. Shrimp sensitization and allergy were assessed in 526 house dust mite (HDM)-allergic patients submitted to the detection of IgE to Der p 10 and 100 atopic control not sensitized to HDM. Results. Shrimp allergy occurred in 9% of patients (vs 0% of 100 atopic controls not sensitized to HDM; p minor 0.001). Shrimp-allergic patients were less frequently hypersensitive to airborne allergens other than HDM than crustacean-tolerant subjects (35% vs 58.8%; p minor 0.005). Only 51% of tropomyosin-sensitized patients had shrimp allergy, and these showed significantly higher Der p 10 IgE levels than shrimp-tolerant ones (mean 22.2 KU/l vs 6.2 KU/l; p minor 0.05). Altogether 53% of shrimp-allergic patients did not react against tropomyosin. Conclusions. Shrimp allergy seems to occur uniquely in association with hypersensitivity to HDM allergens and tropomyosin is the main shrimp allergen but not a major one, at least in Italy. Along with tropomyosin-specific IgE levels, monosensitization to HDM seems to represent a risk factor for the development of shrimp allergy among HDM allergic patients.
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- 2019
27. Targeting IL-12, the Key Cytokine Driving Th1-Mediated Autoimmune Diseases
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Adorini, L., primary, Aloisi, F., additional, Galbiati, F., additional, Gately, M.K., additional, Gregori, S., additional, Penna, G., additional, Ria, F., additional, Smiroldo, S., additional, and Trembleau, S., additional
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- 1997
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28. Study of the effects of Lemna minor extracts on human immune cell populations.
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CARDOSO, C. CATELANI, MIRALDI, E., CECCARINI, M. R., NAUREEN, Z., BAINI, G., MANARA, E., ANPILOGOV, K., CAMILLERI, G., DHULI, K., PAOLACCI, S., RIA, F., DI SANTE, G., CAMPONESCHI, C., TREDICINE, M., ZANLARI, A., CHIURAZZI, P., BECCARI, T., and BERTELLI, M.
- Abstract
OBJECTIVE: Lemna minor is a plant with a huge repertoire of secondary metabolites. The literature indicates that extracts of Lemna minor have antioxidant, antiradical, immunomodulatory and anti-inflammatory properties. The objective of the present study was to find a suitable technique to extract active compounds from this plant and verify whether these extracts have immunomodulatory activity. MATERIALS AND METHODS: We grew L. minor on a standard medium with Gamborg B5 and vitamins. We extracted compounds from the plant by maceration and decoction. The phytochemical profile of the extracts was characterized by chromatography, spectrophotometry, and spectroscopy. The extracts were tested on cultures of mononuclear cells from four human subjects. These cells were pulsed with carboxyfluorescein succinimidyl ester, grown in triplicate in standard culture medium without (control) and with increasing concentrations of Lemna extracts. Flow cytometry was used to evaluate cell death and proliferation of the total mononuclear cell population and of CD4+, CD8+, B cell and monocyte populations. RESULTS: The Lemna extracts were not cytotoxic and did not cause cell necrosis or apoptosis in immune cells. At low concentrations, they induced very limited proliferation of CD4+ cells within 48 hours. At high concentrations, they induced proliferation of CD8+ cells and B lymphocytes within 48 hours. CONCLUSIONS: Unfortunately, we failed to confirm any immunomodulatory activity of Lemna extracts. Growth and death rates of human immune cells were not significantly affected by adding Lemna extracts to the culture medium. [ABSTRACT FROM AUTHOR]
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- 2021
29. Effect of temperature and biomass-water ratio to yield and product characteristics of hydrothermal treatment of biomass
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Rochim Bakti Cahyono, Agus Prasetya, Ahmad Tawfiequrrahman Yuliansyah, Ria F. Rahmawati, Cyrilla Oktaviananda, and Chandra Wahyu Purnomo
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Materials science ,Waste management ,visual_art ,Yield (chemistry) ,visual_art.visual_art_medium ,Biomass ,Hydrothermal treatment ,Heat of combustion ,Sawdust ,Product characteristics ,Raw material ,Pulp and paper industry ,Water content - Abstract
Hydrothemal treatment is a thermochemical process that converts biomass into a coal-like materials called hydrochar by applying elevated temperature to biomass in a suspension with water under saturated pressure for a certain time. With this conversion process, easy to handle fuel with well-defined properties can be created from biomass residues, even with high moisture content. In this research, the effects of temperature (200-330°C) and biomass to water ratio (5%-20%) at initial pressure of 1.0 MPa to hydrothermal treatment of biomass (in the form of sawdust) were examined. All samples were then characterized in terms of yield, proximate analysis, calorific value,and changes in functional groups by FTIR. Approximately 52-69% of the original material was recovered as hydrochar. The gross calorific value ranged from 5472-7032 cal/g compared 5180 cal/g in the raw material. Fixed carbon ranged from 26.035-wt% compared with 26.269 wt% in the raw material.
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- 2017
30. FRI0002 Analysis of b cells and t cells subpopulations and collagen specific t cell repertoire in juvenile idiopathic arthritis patients
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Di Sante, G., primary, Caparello, M.C., additional, Tolusso, B., additional, Di Mario, C., additional, Valentini, M., additional, Ria, F., additional, Ferraccioli, G., additional, Cimaz, R., additional, and Gremese, E., additional
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- 2018
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31. Awareness of medical radiation exposure among patients: A patient survey as a first step for effective communication of ionizing radiation risks
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Ria, F., primary, Bergantin, A., additional, Vai, A., additional, Bonfanti, P., additional, Martinotti, A.S., additional, Redaelli, I., additional, Invernizzi, M., additional, Pedrinelli, G., additional, Bernini, G., additional, Papa, S., additional, and Samei, E., additional
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- 2017
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32. Socioeconomic determinants of childhood injury
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Clarissa V. Buenaventura and Ria F. Campos
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jel:J13 ,jel:J18 ,child injury, risk, logistic regression ,jel:C25 - Abstract
Accidents are the major causes of lifetime incapacity and premature deaths of children ages 1-14. While the country is winning in its fight against communicable diseases by showing a decreasing rate of mortality due to pneumonia, diarrhea, nutritional deficiency, measles, and tuberculosis (tb) of all forms in the past 30 years, the rate of mortality due to accidents has been constant and, at the turn of the century, increasing. This study aims to help in improving preventive actions against unintentional child injuries by identifying the socioeconomic risk factors for injury. Socioeconomic data from the records of trauma patients in the up Philippine General Hospital who applied for medical social service in the year 2006 were analysed using logistic regression. Results of the regression showed that male children living with only one adult and who have a younger, less educated mother are more at risk of getting injured. Paternal characteristics turned out to have an opposite sign than that of maternal characteristics, implying that older and more educated fathers offer less preventive efforts for child injury.
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- 2008
33. Adaptability index: quantifying CT tube current modulation performance from dose and quality informatics
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Ria, F., additional, Wilson, J. M., additional, Zhang, Y., additional, and Samei, E., additional
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- 2017
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34. Effect of temperature and biomass-water ratio to yield and product characteristics of hydrothermal treatment of biomass
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Oktaviananda, Cyrilla, primary, Rahmawati, Ria F., additional, Prasetya, Agus, additional, Purnomo, Chandra W., additional, Yuliansyah, Ahmad T., additional, and Cahyono, Rochim B., additional
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- 2017
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35. Study to Define Frequency in Routine Analytical Controls in the Radiolabelling Process
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Ria, F., primary, Albini, G., additional, Battista, S., additional, Salvatore, V., additional, Messere, R., additional, Bergantin, A., additional, Redaelli, I., additional, Bonfanti, P., additional, Martinotti, A. S., additional, Gandolfo, P., additional, and Papa, S., additional
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- 2017
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36. Modeling rejection immunity
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De Gaetano, A, Matone, A, Agnes, A, Palumbo, P, Ria, F, Magalini, S, De Gaetano, A., Matone, A., Agnes, A., Ria, F., De Gaetano, A, Matone, A, Agnes, A, Palumbo, P, Ria, F, Magalini, S, De Gaetano, A., Matone, A., Agnes, A., and Ria, F.
- Abstract
Background Transplantation is often the only way to treat a number ofdiseases leading to organ failure. To overcome rejection towards the trans-planted organ (graft), immunosuppression therapies are used, which haveconsiderable side-effects and expose patients to opportunistic infections. Thedevelopment of a model to complement the physician's experience in speci-fying therapeutic regimens is therefore desirable.The present work proposes an Ordinary Differential Equations model ac-counting for immune cell proliferation in response to the sudden entry ofgraft antigens, through different activation mechanisms. The model consid-ers the effect of a single immunosuppressive medication (e.g. cyclosporine),subject to first-order linear kinetics and acting by modifying, in a saturableconcentration-dependent fashion, the proliferation coefficient. The latter hasbeen determined experimentally. All other model parameter values havebeen set so as to reproduce reported state variable time-courses, and tomaintain consistency with one another and with the experimentally derivedproliferation coefficient.Results The proposed model substantially simplifies the chain of eventspotentially leading to organ rejection. It is however able to simulate quanti-tatively the time course of graft-related antigen and competent immunore-active cell populations, showing the long-term alternative outcomes of rejec-tion, tolerance or tolerance at a reduced functional tissue mass. In particu-lar, the model shows that it may be difficult to attain tolerance at full tissuemass with acceptably low doses of a single immunosuppressant, in accordwith clinical experience.Conclusions The introduced model is mathematically consistent with knownphysiology and can reproduce variations in immune status and allograft sur-vival after transplantation. The model can be adapted to represent differenttherapeutic schemes and may offer useful indications for the optimization oftherapy protocols in the transplanted patien
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- 2012
37. SU‐F‐I‐48: Variability in CT Scanning Over‐Range Across Clinical Operation
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Ria, F, primary, Wilson, J M, additional, Guntzer, P, additional, Zanca, F, additional, and Samei, E, additional
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- 2016
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38. 102P: Ablative robotic radiosurgery for inoperable patients with stage IA–IB non small cell lung cancer
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Zanetti, I. Bossi, primary, Scanagatta, P., additional, Bianchi, L.C., additional, Bergantin, A., additional, Martinotti, A.S., additional, Redaelli, I., additional, Ria, F., additional, Vai, A., additional, Invernizzi, M., additional, and Beltramo, G., additional
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- 2016
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39. PO-0857: GTV-based prescription and Monte Carlo treatment planning in Cyberknife treatments for lung lesions
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Vai, A., primary, Bonfanti, P., additional, Invernizzi, M., additional, Martinotti, A., additional, Redaelli, I., additional, Ria, F., additional, Beltramo, R., additional, Bianchi, L.C., additional, Bossi Zanetti, I., additional, and Bergantin, A., additional
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- 2016
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40. Monte Carlo-corrected GTV dose prescription on lung tumors treated with Cyberknife: A possible recipe
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Vai, A., primary, Bonfanti, P., additional, Martinotti, A.S., additional, Redaelli, I., additional, Ria, F., additional, and Bergantin, A., additional
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- 2016
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41. Application of the EUREF protocol for acceptance test of three digital breast tomosynthesis systems
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Bonfanti, P., primary, Invernizzi, M., additional, Martinotti, A., additional, Redaelli, I., additional, Ria, F., additional, Vai, A., additional, and Bergantin, A., additional
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- 2016
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42. Functional dissection of protein domains involved in the immunomodulatory properties of PE_PGRS33 of Mycobacterium tuberculosis.f protein domains involved in the immune-modulatory properties of PE_PGRS33 of Mycobacterium tuberculosis
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Zumbo, A, Palucci, I, Cascioferro, A, Sali, M, Ventura, M, P Iantomasi R, D'Alfonso, DI SANTE, G, Ria, F, Sanguinetti, M, Fadda, G, Manganelli, R, and Delogu, G.
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- 2013
43. Regulation of and regulation by CD44: a paradigm complex regulatory network
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Di Sante, G, Migliara, Giuseppe, Valentini, M, Delogu, G, and Ria, F.
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- 2013
44. New therapeutic targets in rheumatoid arthritis: selective inhibitors of recognition of TCR/MHCII-collagen complex. Drug
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Pirolli D., Giardina B., Ferraccioli G., Ria F., and De Rosa M.C.
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- 2013
45. Modeling TCR-p/MHC interactions associated with rheumatoid arthritis
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De Rosa M.C., Ria F., Bianchi C., Pirolli D., Ferraccioli G., and Giardina B.
- Published
- 2010
46. Surface expression of MPT64 as a fusion with the PE domain of PE_PGRS33 enhances BCG protective activity against Mycobacterium tuberculosis in mice
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Sali, M, DI SANTE, G, Cascioferro, Alessandro, Zumbo, A, Nicolã’, C, DONÀ, V, Rocca, S, Ria, F, Palu', Giorgio, Fadda, G, Manganelli, Riccardo, and Delogu, G.
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- 2010
47. Modeling rejection immunity
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De Gaetano, A., Matone, A., Agnes, A.M., Palumbo, P., Ria, F., and Magalini, S.
- Published
- 2010
48. P076 Stereotactic body radiation therapy in the treatment of oligometastatic prostate cancer
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Beltramo, G., primary, Matei, V., additional, Bergantin, A., additional, Martinotti, A.S., additional, Vite, C., additional, Ria, F., additional, Invernizzi, M., additional, and Bianchi, L.C., additional
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- 2014
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49. P015 Prostate hypofractionated stereotactic ablative body radiotherapy: Disease control and quality of life at 6 years
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Beltramo, G., primary, Bergantin, A., additional, Martinotti, A.S., additional, Vite, C., additional, Ria, F., additional, Invernizzi, M., additional, and Bianchi, L.C., additional
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- 2014
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50. The PLASMONX Project for advanced beam physics experiments
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Alesini, D., Bellaveglia, M., Bertolucci, S., Boni, R., Boscolo, M., Castellano, M., Clozza, A., Dipirro, G., Drago, A., Esposito, A., Ferrario, M., Ficcadenti, L., Filippetto, D., Fusco, V., Gatti, G., Gallo, A., Ghigo, A., Incurvati, M., Ligi, C., Pellegrino, L., Preger, M., Ricci, R., Sanelli, C., Serio, M., Sgamma, F., Spataro, B., Stecchi, A., Stella, A., Tazzioli, F., Vaccarezza, C., Vescovi, M., Vicario, C., Aless, Ria, F., Bacci, A., Bonifacio, R., Broggi, F., Cola, M., Demartinis, C., Giove, D., Maroli, C., Mauri, M., Petrillo, V., Piovella, N., Pozzoli, R., Romè, M., Rossi, A. R., Serafini, L., Volpe, L., Levi, D., Mattioli, M., Musumeci, P., Medici, G., Pelliccia, D., Petrarca, M., Bottigli, U., Golosio, B., Oliva, P., Poggiu, A., Stumbo, S., Barbini, A., Baldeschi, W., Cecchetti, C. A., Galimberti, M., Giulietti, A., Giulietti, D., Gizzi, L. A., Koester, P., Labate, L., Laville, S., Rossi, A., Tomassini, P., Palumbo, Luigi, Mattioli, Mario Claudio, Petrarca, Massimo, Migliorati, Mauro, and Mostacci, Andrea
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X band - Published
- 2006
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