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496 results on '"Rhodes, Lesley E."'

7. Association between prescribed oral antidiabetic medication for type 2 diabetes mellitus and risk of skin cancer: a systematic review and meta-analysis.

Author

Simpson, Corey, Leducq, Sophie, Venables, Zoe, Yiu, Zenas Z N, Rhodes, Lesley E, Idris, Iskandar, and Gran, Sonia

Subjects
BASAL cell carcinoma, TYPE 2 diabetes, SKIN cancer, MEDICAL research, TYPE 1 diabetes
Abstract

The article published in the British Journal of Dermatology explores the association between prescribed oral antidiabetic medication (OADM) for type 2 diabetes mellitus and the risk of developing skin cancer. The systematic review and meta-analysis included studies from various geographical locations and ethnicities, focusing on basal cell carcinoma (BCC), cutaneous squamous cell carcinoma (cSCC), and melanoma. The findings suggest that metformin may decrease the risk of skin cancer compared to other OADM, with a dose-response relationship observed for metformin and rosiglitazone exposure. However, the certainty of evidence remains low, indicating the need for further research to confirm causality between OADM and skin cancer risk. [Extracted from the article]

Published
2025
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12. Ozone depletion, ultraviolet radiation, climate change and prospects for a sustainable future

Author

Barnes, Paul W., Williamson, Craig E., Lucas, Robyn M., Robinson, Sharon A., Madronich, Sasha, Paul, Nigel D., Bornman, Janet F., Bais, Alkiviadis F., Sulzberger, Barbara, Wilson, Stephen R., Andrady, Anthony L., McKenzie, Richard L., Neale, Patrick J., Austin, Amy T., Bernhard, Germar H., Solomon, Keith R., Neale, Rachel E., Young, Paul J., Norval, Mary, Rhodes, Lesley E., Hylander, Samuel, Rose, Kevin C., Longstreth, Janice, Aucamp, Pieter J., Ballaré, Carlos L., Cory, Rose M., Flint, Stephan D., de Gruijl, Frank R., Häder, Donat-P., Heikkilä, Anu M., Jansen, Marcel A. K., Pandey, Krishna K., Robson, T. Matthew, Sinclair, Craig A., Wängberg, Sten-Åke, Worrest, Robert C., Yazar, Seyhan, Young, Antony R., and Zepp, Richard G.

Published
2019
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13. Comparative Study of Healthy Older and Younger Adults Shows They Have the Same Skin Concentration of Vitamin D 3 Precursor, 7-Dehydrocholesterol, and Similar Response to UVR.

Author

Borecka, Oktawia, Dutton, John J., Tang, Jonathan C. Y., Fraser, William D., Webb, Ann R., and Rhodes, Lesley E.

Abstract

Vitamin D3 synthesis in human skin is initiated by solar ultraviolet radiation (UVR) exposure of precursor 7-dehydrocholesterol (7DHC), but influence of age on the early stage of vitamin D3 metabolism is uncertain. We performed a prospective standardised study in healthy ambulant adults aged ≥65 and ≤40 years examining (1) if baseline skin 7DHC concentration differs between younger and older adults and (2) the impact of older age on serum vitamin D3 response to solar simulated UVR. Eleven younger (18–40 years) and 10 older (65–89 years) adults, phototype I–III, received low-dose UVR (95% UVA, 5% UVB, 1.3 SED) to ~35% of the body surface area. Biopsies were taken for 7DHC assay from unexposed skin, skin immediately and 24 h post-UVR, and blood sampled at baseline, 24 h and 7 d post-UVR for vitamin D3 assay. Samples were analysed by HPLC-MS/MS. Baseline skin 7DHC (mean ± SD) was 0.22 ± 0.07 and 0.25 ± 0.08 µg/mg in younger versus older adults (no significant difference). Baseline serum vitamin D3 concentration was 1.5 ± 1.5 and 1.5 ± 1.7 nmol/L in younger versus older adults, respectively, and showed a significant increase in both groups post-UVR (no significant differences between age groups). Thus, skin 7DHC concentration was not a limiting factor for vitamin D3 production in older relative to younger adults. This information assists public health guidance on sun exposure/vitamin D nutrition, with particular relevance to the growing populations of healthy ambulant adults ≥65 years. [ABSTRACT FROM AUTHOR]

Published
2024
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16. Environmental Effects of Stratospheric Ozone Depletion, UV Radiation, and interactions with Climate Change: 2022 Assessment Report

Author

Andrady, Anthony L, Aucamp, Pieter J, Bais, Alkiviadis F, Barnes, Paul W, Bernhard, Germar H, Bornman, Janet F, Hader, D P, Heikkila, Anu M, Hylander, Samuel, Longstreth, Janice, Madronich, Sasha, Neale, Patrick J, Neale, Rachel, Pandey, Krishna K, Rhodes, Lesley E, Robinson, Sharon A, Robson, Matthew, Rose, Kevin C, Sulzberger, Barbara, Williamson, Craig E, White, Christopher C, Zepp, Richard G, Wilson, Stephen R, Wangberg, Sten-Ake, Yazar, Seyhan, Young, Antony R, Andrady, Anthony L, Aucamp, Pieter J, Bais, Alkiviadis F, Barnes, Paul W, Bernhard, Germar H, Bornman, Janet F, Hader, D P, Heikkila, Anu M, Hylander, Samuel, Longstreth, Janice, Madronich, Sasha, Neale, Patrick J, Neale, Rachel, Pandey, Krishna K, Rhodes, Lesley E, Robinson, Sharon A, Robson, Matthew, Rose, Kevin C, Sulzberger, Barbara, Williamson, Craig E, White, Christopher C, Zepp, Richard G, Wilson, Stephen R, Wangberg, Sten-Ake, Yazar, Seyhan, and Young, Antony R

Abstract

The Montreal Protocol on Substances that Deplete the Ozone Layer was established 35 years ago following the 1985 Vienna Convention for protection of the environment and human health against excessive amounts of harmful ultraviolet-B (UV-B, 280-315 nm) radiation reaching the Earth’s surface due to a reduced UV-B-absorbing ozone layer. The Montreal Protocol, ratified globally by all 198 Parties (countries), controls ca 100 ozone-depleting substances (ODS). These substances have been used in many applications, such as in refrigerants, air conditioners, aerosol propellants, fumigants against pests, fire extinguishers, and foam materials. The Montreal Protocol has phased out nearly 99% of ODS, including ODS with high global warming potentials such as chlorofluorocarbons (CFC), thus serving a dual purpose. However, some of the replacements for ODS also have high global warming potentials, for example, the hydrofluorocarbons (HFCs). Several of these replacements have been added to the substances controlled by the Montreal Protocol. The HFCs are now being phased down under the Kigali Amendment. As of December 2022, 145 countries have signed the Kigali Amendment, exemplifying key additional outcomes of the Montreal Protocol, namely, that of also curbing climate warming and stimulating innovations to increase energy efficiency of cooling equipment used industrially as well as domestically. As the concentrations of ODS decline in the upper atmosphere, the stratospheric ozone layer is projected to recover to pre-1980 levels by the middle of the 21st century, assuming full compliance with the control measures of the Montreal Protocol. However, in the coming decades, the ozone layer will be increasingly influenced by emissions of greenhouse gases and ensuing global warming. These trends are highly likely to modify the amount of UV radiation reaching the Earth's surface with implications for the effects on ecosystems and human health. Against this background, four Panels of expert

Published
2023

33. Vitamin D status in patients with erythropoietic protoporphyria taking the systemic photoprotective agent afamelanotide.

Author

Rhodes, Lesley E

Subjects
*VITAMIN D, *SUNSHINE, *ERYTHROPOIETIC protoporphyria, *DIETARY supplements, *RANDOMIZED controlled trials, *SUNBURN
Abstract

The article discusses the impact of the systemic photoprotective agent afamelanotide on the vitamin D status of patients with erythropoietic protoporphyria (EPP). EPP is a rare condition that causes severe pain when the skin is exposed to visible light. Afamelanotide has been shown to increase the length of time patients can spend in the sun without pain and improve their quality of life. However, the study found that afamelanotide had no impact on vitamin D status, suggesting that vitamin D assessment and supplementation are still necessary for patients with EPP. [Extracted from the article]

Published
2024
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39. Systematic review of the prevalence and incidence of the photodermatoses with meta‐analysis of the prevalence of polymorphic light eruption.

Author

Burfield, Laura, Rutter, Kirsty J., Thompson, Bridie, Marjanovic, Elizabeth J., Neale, Rachel E., and Rhodes, Lesley E.

Subjects
QUALITY of life, CINAHL database, PHOTOSENSITIVITY, ENGLISH literature, PRURIGO
Abstract

Information about the prevalence of photodermatoses is lacking, despite their substantial impact on life quality. Our objective was to systematically review the literature to establish what is known regarding prevalence and incidence of photodermatoses. We searched Medline, CINAHL and Embase from inception to 2021 to identify original population‐based studies in English literature reporting the prevalence and/or incidence of photodermatoses. Information was extracted according to geographical location and risk of bias was assessed using a 10‐point risk of bias tool for prevalence studies. Primary outcome was the population prevalence of photodermatoses. Prevalence data for polymorphic light eruption (PLE) were used to calculate the global pooled prevalence of PLE. Twenty‐six studies were included; 15 reported prevalence of photodermatoses based on samples of the general population and 11 on prevalence and/or incidence from national and international registry data. The general population studies involved PLE (nine studies), unspecified photosensitivity (2), actinic prurigo (2), juvenile spring eruption (1), chronic actinic dermatitis (1) and variegate porphyria (1), while registry studies reported on cutaneous porphyrias and genophotodermatoses (nine and two studies, respectively). Worldwide the prevalence of PLE between countries ranged from 0.65% (China) to 21.4% (Ireland). The pooled estimated prevalence of PLE was 10% (95% CI 6%–15%) among the general population (n = 19,287), and PLE prevalence increased with distance from the equator (r = 0.78, p < 0.001). While several photodermatoses are rare, photosensitivity can be prevalent at wide‐ranging world locations, including Egypt where photosensitivity was found in 4% of children and 10% of adults. This study showed that PLE is highly prevalent in many populations and that its prevalence shows a highly significant correlation with increasing northerly or southerly latitude. Available population‐based studies for photodermatoses suggest they can be prevalent at a range of world locations; more attention is required to this area. [ABSTRACT FROM AUTHOR]

Published
2023
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41. Dose-response for change in 25-hydroxyvitamin D after UV exposure:outcome of a systematic review

Author

Webb, Ann R, Alghamdi, Rehab, Kift, Richard, and Rhodes, Lesley E

Abstract

A systematic review of publications addressing change in vitamin D status (25-hydroxyvitamin D (25OHD)) after exposure to UV radiation identified 2001 independent peer-reviewed publications. Of these, 21 used artificial sources of UV radiation, met all inclusion criteria and were quality assured; 13 publications used solar radiation and met sufficient inclusion criteria to be retained as supporting evidence; 1 further included publication used both solar and artificial sources. The review consistently identified that low dose, sub-erythemal doses are more effective for vitamin D synthesis than doses close to a minimum erythema dose; increasing skin area exposed increases the amount of vitamin D synthesised although not necessarily in a linear manner; constant dosing leads to a dose-dependent plateau in 25OHD, and dose–response is greatest at the start of a dosing regime; there is a large interpersonal variation in response to UV exposure. Fourteen of the studies using artificial sources of radiation were used to determine a dose–response relationship for change in 25OHD on whole-body exposure to repeated sub-erythemal doses of UV radiation, taking the form Δ25OHD (nmol/L) = A ln(standard vitamin D dose) + B. This helps quantify our understanding of UV as a source of vitamin D and enables exposure regimes for safe synthesis of vitamin D to be assessed. Specific studies of people with pigmented skin (Fitzpatrick skin types 5 and 6) were rare, and this dose–response relationship is only applicable to white-skinned individuals as skin type is a determinant of response to UV radiation. Findings provide information for vitamin D guidance updates.

Published
2021
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42. Role of distinct fibroblast lineages and immune cells in dermal repair following UV radiation-induced tissue damage

Author

Rognoni, Emanuel, primary, Goss, Georgina, additional, Hiratsuka, Toru, additional, Sipilä, Kalle H, additional, Kirk, Thomas, additional, Kober, Katharina I, additional, Lui, Prudence PokWai, additional, Tsang, Victoria SK, additional, Hawkshaw, Nathan J, additional, Pilkington, Suzanne M, additional, Cho, Inchul, additional, Ali, Niwa, additional, Rhodes, Lesley E, additional, and Watt, Fiona M, additional

Published
2021
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45. Afamelanotide for Erythropoietic Protoporphyria

Author

Langendonk, Janneke G., Balwani, Manisha, Anderson, Karl E., Bonkovsky, Herbert L., Anstey, Alexander V., Bissell, D. Montgomery, Bloomer, Joseph, Edwards, Chris, Neumann, Norbert J., Parker, Charles, Phillips, John D., Lim, Henry W., Hamzavi, Iltefat, Deybach, Jean-Charles, Kauppinen, Raili, Rhodes, Lesley E., Frank, Jorge, Murphy, Gillian M., Karstens, Francois P.J., Sijbrands, Eric J.G., de Rooij, Felix W.M., Lebwohl, Mark, Naik, Hetanshi, Goding, Colin R., Paul Wilson, J. H., and Desnick, Robert J.

Published
2015
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46. Author response: Role of distinct fibroblast lineages and immune cells in dermal repair following UV radiation-induced tissue damage

Author

Rognoni, Emanuel, primary, Goss, Georgina, additional, Hiratsuka, Toru, additional, Sipilä, Kalle H, additional, Kirk, Thomas, additional, Kober, Katharina I, additional, Lui, Prudence PokWai, additional, Tsang, Victoria SK, additional, Hawkshaw, Nathan J, additional, Pilkington, Suzanne M, additional, Cho, Inchul, additional, Ali, Niwa, additional, Rhodes, Lesley E, additional, and Watt, Fiona M, additional

Published
2021
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