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The case study of a 54-year-old female admitted to the hospital manifesting respiratory failure, hypotension and a cavitary lesion in the lung is discussed. The condition was diagnosed as an old case of rheumatoid arthritis which could lead to pulmonary complications and the line of treatment adopted is highlighted.

ABSTRACT Treatment of patients with moderate-severe psoriasis and/or psoriatic arthritis includes systemic biologic, antimetabolite, and immunosuppressive therapy. However, adverse events such as serious infectious complications must be considered before starting [...]

The symptoms, diagnosis with the use of laboratory tests and management of the case of rheumatoid arthritis with lymphadenopathy are discussed.

The case study of a 25-year-old woman with rheumatoid arthritis who was evaluated for possible tumor necrosis factor (TNF) inhibitor therapy is presented. The clinical details and the pathophysiology and effects of the therapy are described along with some general guidelines and recommendations related to the case.

Summary This article aims to inform general nurses about the management of patients with rheumatoid arthritis. It outlines the signs and symptoms, disease processes and treatment, and highlights the importance [...]

We report a case of definite rheumatoid arthritis and co-existing gout. Although gout and rheumatoid arthritis are relatively common entities individually, the co-existence of these two conditions is rare. KEY [...]

HIV infected patients show microsporadia caused by chronic diarrheal syndromes. A case report of a 57-year-old woman with rheumatoid arthritis and diabetes receiving infliximab identified the mosquito pathogen Brachiola algerae as the cause of fatal myositis.

Byline: Carol A. Blanchong (1), Randal Olshefski (1), Samir Kahwash (3) Keywords: Key words: child, large granular lymphocyte leukemia, neutropenia, rheumatoid arthritis Abstract: Lymphoproliferative disorders of large granular lymphocytes (LGL) are heterogeneous, with a clinical/pathologic spectrum ranging from a benign polyclonal expansion to an aggressive clonal disease. Often these lymphoproliferative disorders are associated with autoimmune disease. The clonal form of the disorder, LGL leukemia, typically occurs in older adults with a median age of 55 years at diagnosis. Pediatric cases are referred to in review articles however, no detailed reports of T-cell LGL leukemia in children exist. This report illustrates a case of a child who presented initially at age 2 and 1/2 years with psoriasis, juvenile rheumatoid arthritis-like symptoms, and neutropenia. Bone marrow examinations obtained throughout his course have demonstrated progressive hypercellularity with increased reticulin fibers and replacement of the normal marrow elements by lymphocytes, which were later identified as large granular lymphocytes. Further testing with immunophenotyping by flow cytometry and T-cell receptor gene rearrangement studies revealed a monoclonal proliferation of large granular lymphocytes and confirmed a diagnosis of LGL leukemia. Although rare, large granular lymphocyte leukemia should be included in the differential diagnosis of chronic neutropenia in children. Author Affiliation: (1) Division of Hematology/Oncology, Columbus Children's Hospital, the Ohio State University, 700 Children's Drive, Columbus, OH 43205, USA, US (2) Department of Pediatrics, Columbus Children's Hospital, the Ohio State University, 700 Children's Drive, Columbus, OH 43205, USA, US (3) Department of Laboratory Medicine, Columbus Children's Hospital, the Ohio State University, 700 Children's Drive, Columbus, OH 43205, USA, US Article note: Received September 15, 1999 accepted May 18, 2000.

Byline: M.B. McDermott (1), A.C. Lind (1), E.F. Marley (1), L.P. Dehner (1) Keywords: Key words: granuloma annulare, pseudorheumatoid nodule, palisading granuloma, necrobiosis, granulomatous inflammation, necrotizing granuloma Abstract: Deep granuloma annulare (DGA) is one of several lesions of skin and superficial soft tissues whose histologic character is a palisading granuloma with a small central focus of necrosis or necrobiosis. Unlike the other palisading necrobiotic lesions, DGA has a predilection for children in the first 5 to 6 years of life. A painless subcutaneous nodule(s) in the lower anterior tibial region or foot and the scalp, typically in the occiput, was the most common presenting feature in this study of 35 cases. Additional or recurrent lesions were reported in approximately 70% of cases with clinical follow-up. All lesions showed the presence of necrobiosis however, one of the characteristic features was the multinodular character of the predominantly mononuclear cellular aggregates. The presence of vascular spaces at the periphery of the nodular profiles served as a clue to the diagnosis of DGA. The palisading arrangement of the mononuclear cells was evident only in those foci with central necrobiosis. A histiocytic disorder or fibrohistiocytic process was a common consideration in the differential diagnosis, especially in those cases with less apparent foci of necrosis. Palisading histiocytes with prominent eosinophilic cytoplasm and some nuclear atypism were problematic with regard to possible epithelioid sarcoma. Our study failed to identify any underlying or predisposing factors in the development of DGA. Despite the fact that DGA is a well-documented lesion in children, it occurs sufficiently infrequently that it is often not considered clinically when it presents as a subcutaneous mass or masses in a child. Its recognition by the pathologist is especially important as the occurrence of additional lesions in a high proportion of children can be anticipated without undue concern. Author Affiliation: (1) The Lauren V. Ackerman Laboratory of Surgical Pathology, Barnes-Jewish Hospital and St. Louis Children's Hospital, Washington University Medical Center, St. Louis, MO 63110, USA , US (2) Division of Anatomic Pathology, Barnes-Jewish Hospital (South Campus), 1 Barnes-Jewish Hospital Plaza, St. Louis, MO 63110, USA , US Article note: Received June 16, 1997 accepted October 28, 1997.

Byline: Bethany J. Foster (1), Ciaran M. Duffy (1), Atul K. Sharma (1) Keywords: Key words: Systemic-onset juvenile rheumatoid arthritis; Membranous nephropathy; Crescentic glomerulonephritis; Intravenous immune globulin Abstract: Systemic-onset juvenile rheumatoid arthritis (JRA) is a complex disease which affects many organ systems. Associated renal lesions are unusual, with the possible exception of amyloidosis. We describe a girl with systemic-onset JRA who developed first membranous nephropathy and then, 3.5 years later, a severe crescentic glomerulonephritis. The membranous lesion followed therapy with intravenous immune globulin, and the possibility that this intervention caused the renal disease must be considered. It appears that both of these lesions should be added to the list of possible complications of systemic-onset JRA. Author Affiliation: (1) Montreal Children's Hospital, McGill University, Montreal, Quebec, Canada, CA Article note: Received January 16, 1997 received in revised form July 29, 1997 accepted July 31, 1997

Wolfgang Amadeus Mozart may have died from febrile rheumatoid arthritis with amyloidosis. Descriptions of various illnesses he had in earlier years suggest that he had Still's disease, an acute systemic illness which develops in juveniles. Some of its symptoms in Mozart may have been misdiagnosed by historians as typhoid fever or typhus.

The article highlights the importance of assessing the condition of the patient before inclusion in gene-therapy trials. The author reviews the case of a young woman who died following participation in phase 1-2 gene-therapy for rheumatoid arthritis.

INTRODUCTION Pustular psoriasis is a type of psoriasis characterized by erythema, scaling, and superficial pustules. While some forms of pustular psoriasis can be widespread and life-threatening, other variants are more [...]

Bernatsky S, Panopalis P, Pineau CA, et al, McGill University Health Centre and Jewish General Hospital, Montreal. Healthcare costs of inflammatory myopathies. J Rheumatol. 2011;38:885-888. The economic burden associated with [...]

The results of an investigation for a case of disseminated histoplasmosis along with retroperitoneal bleeding and being treated by a gene-therapy under clinical trials is believed to have caused death are presented. The treatment was for rheumatoid arthritis which is an inflammation of joints marked by autoimmune destruction of multiple joints and suggests proper monitoring dadof patients during the trial.