1. Variation in prenatal surveillance and management of anti-SSA/Ro autoantibody positive pregnancies.
- Author
-
Howley, Lisa W., Eyerly-Webb, Stephanie A., Killen, Stacy A. S., Paul, Erin, Krishnan, Anita, Gropler, Melanie R. F., Drewes, Bailey, Dion, Eric, Lund, Amy, Buyon, Jill P., and Cuneo, Bettina F.
- Subjects
- *
HEART block , *FETAL heart , *RHEUMATISM , *AUTOANTIBODIES , *REFERENCE values - Abstract
Objective: To describe international surveillance and treatment strategies for managing anti-SSA/Ro autoantibody positive pregnancies. Study Design: An electronic REDCap questionnaire was distributed to Fetal Heart Society and North American Fetal Therapy Network members which queried institution-based risk stratification, surveillance methods/frequency, conduction abnormality treatments, and postnatal anti-SSA/Ro pregnancy assessment. Results: 101 responses from 59 centers (59% US, 17% international) were collected. Most (79%) do not risk stratify pregnancies by anti-SSA/Ro titer; those that do use varied cutoff values. Many pregnant rheumatology patients are monitored for cardiac abnormalities regardless of maternal anti-SSA/Ro status. Surveillance strategies were based on maternal factors (anti-SSA/Ro status 85%, titer 25%, prior affected child 79%) and monitoring durations varied. Most respondents treat 2° and 3° fetal atrioventricular block, commonly with dexamethasone and/or IVIG. Conclusions: Wide variation exists in current fetal cardiac surveillance and treatment for anti-SSA/Ro autoantibody positive pregnancies, highlighting the need for evidence-based protocols to optimize care. [ABSTRACT FROM AUTHOR] more...
- Published
- 2024
- Full Text
- View/download PDF