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Purpose: The aim of this study was to evaluate the relationship between semiquantitative parameters on F-FDG PET/CT including maximum standardized uptake value (SUVmax), mean standardized uptake value (SUVmean), metabolic tumor volume (MTV), and total lesion glycolysis (TLG) and the expression level of Ki-67 in small-cell lung cancer (SCLC). Methods: Ninety-four consecutive patients with SCLC were enrolled in this study. They underwent F-FDG PET/CT for initial evaluation of SCLC, and we measured SUVmax, avgSUVmean, MTVsum, and TLGtotal on F-FDG PET/CT images. The protein expression of Ki-67 was examined by immunohistochemical staining. Results: Significant correlations were found between the MTVsum and Ki-67 labeling index ( r = 0.254, p = 0.014) and the TLGtotal and Ki-67 labeling index ( r = 0.239, p = 0.020). No correlation was found between the SUVmax and Ki-67 labeling index ( r = 0.116, p = 0.264) and the avgSUVmean and Ki-67 labeling index ( r = 0.031, p = 0.770). Dividing the Ki-67 expression level into three categories, it was suggested that increasing Ki-67 expression level caused a stepwise increase in the MTVsum and TLGtotal. ( p = 0.028 and 0.039, respectively), but not the SUVmax and avgSUVmean ( p = 0.526 and 0.729, respectively). Conclusion: In conclusion, the volume-based parameters of F-FDG PET/CT correlate with immunohistochemical staining of Ki-67 in SCLC. Measurement of the MTVsum and TLGtotal by F-FDG PET/CT might be a simple, noninvasive, and useful method to determine the proliferative potential of cancer cells. [ABSTRACT FROM AUTHOR]

Objectives: The purpose of this study is to evaluate the correlation between pretreatment planning technetium-99m (Tc) macroaggregated albumin (MAA) SPECT images and posttreatment transarterial radioembolization (TARE) yttirum-90 (Y) PET/CT images by comparing the ratios of tumor-to-normal liver counts. Methods: Fifty-two patients with advanced hepatic malignancy who underwent Y microsphere radioembolization from January 2010 to December 2012 were retrospectively reviewed. Patients had undergone Tc MAA intraarterial injection SPECT for a pretreatment evaluation of microsphere distribution and therapy planning. After the administration of Y microspheres, the patients underwent posttreatment Y PET/CT within 24 h. For semiquantitative analysis, the tumor-to-normal uptake ratios in Y PET/CT (TNR-yp) and Tc MAA SPECT (TNR-ms) as well as the tumor volumes measured in angiographic CT were obtained and analyzed. The relationship of TNR-yp and TNR-ms was evaluated by Spearman's rank correlation and Wilcoxon's matched pairs test. Results: In a total of 79 lesions of 52 patients, the distribution of microspheres was well demonstrated in both the SPECT and PET/CT images. A good correlation was observed of between TNR-ms and TNR-yp (rho value = 0.648, p < 0.001). The TNR-yp (median 2.78, interquartile range 2.43) tend to show significantly higher values than TNR-ms (median 2.49, interquartile range of 1.55) ( p = 0.012). The TNR-yp showed weak correlation with tumor volume (rho = 0.230, p = 0.041). Conclusions: The Tc MAA SPECT showed a good correlation with Y PET/CT in TNR values, suggesting that Tc MAA can be used as an adequate pretreatment evaluation method. However, the Tc MAA SPECT image consistently shows lower TNR values compared to Y PET/CT, which means the possibility of underestimation of tumorous uptake in the partition dosimetry model using Tc MAA SPECT. Considering that Tc MAA is the only clinically available surrogate marker for distribution of microsphere, we recommend measurement of tumorous uptake using Y PET/CT should be included routinely in the posttherapeutic evaluation. [ABSTRACT FROM AUTHOR]

Purpose: Ovarian cancer is a leading cause of gynecologic malignancy. As symptoms of ovarian cancer are nonspecific, only 20 % of ovarian cancers are diagnosed while they are still limited to the ovaries. Thus, early and accurate detection of disease is important for an improved prognosis. For the accurate and effective diagnosis of ovarian malignancy on F-fluorodeoxyglucose (F-FDG) positron emission tomography/computed tomography (PET/CT), we analyzed several parameters, including visual assessment. Method: A total of 51 peritoneal lesions in 19 patients who showed ovarian masses with diffuse peritoneal infiltration were enrolled. Twelve patients were confirmed to have ovarian malignancy and seven patients with benign disease by pathologic examination. All patients were examined by F-FDG PET/CT, and an additional 2-h delayed F-FDG PET/CT was also performed for 15 patients with 42 peritoneal lesions. We measured semiquantitative parameters including maximum and mean standardized uptake values (SUVmax, SUVmean), metabolic tumor volume (MTV), and total lesion glycolysis (TLG) on a 1-h initial F-FDG PET/CT image (Parameter) and on a 2-h delayed image (Parameter). Additionally, retention indices of each parameter were calculated, and each parameter among the malignant and benign lesions was compared by Mann-Whitney U test. We also assessed the visual characteristics of each peritoneal lesion, including metabolic extent, intensity, shape, heterogeneity, and total visual score. Associations between visual grades and malignancy were analyzed using linear by linear association methods. Moreover, a receiver operating characteristic (ROC) curve was analyzed to compare the effectiveness of significant parameters. Result: In a comparison between the malignant and benign groups in the analysis of 51 total peritoneal lesions, SUVmax, SUVmean, and TLG showed significant differences. Also, in the analysis of 42 peritoneal lesions that underwent an additional 2-h F-FDG PET/CT examination, SUVmax, SUVmean, TLG, and the RI of TLG showed significant differences between the malignant and benign groups. MTV did not show significant differences in either the analysis of 51 peritoneal lesions or of 42 lesions. Regarding visual assessments, metabolic intensity, shape, heterogeneity, and total visual score showed an association with malignancy. In the ROC analysis, the AUC of the visual score was larger than the AUC of other parameters in both the analyses of 51 peritoneal lesions and of 42 lesions. Conclusion: Although further study with a larger patient population is needed, the visual assessment of F-FDG PET/CT imaging has a primary role in the detection of malignancy in ovarian cancer patients with assistance from other semi-quantitative parameters. [ABSTRACT FROM AUTHOR]

Thyroid incidentalomas are common findings during imaging studies including F-fluorodeoxyglucose (F-FDG) positron emission tomography/computed tomography (PET/CT) for cancer evaluation. Although the overall incidence of incidental thyroid uptake detected on PET imaging is low, clinical attention should be warranted owing to the high incidence of harboring primary thyroid malignancy. We retrospectively reviewed 2,368 dual-time-point F-FDG PET/CT cases that were undertaken for cancer evaluation from November 2007 to February 2009, to determine the clinical impact of dual-time-point imaging in the differential diagnosis of thyroid incidentalomas. Focal thyroid uptake was identified in 64 PET cases and final diagnosis was clarified with cytology/histology in a total of 27 patients with F-FDG-avid incidental thyroid lesion. The maximum standardized uptake value (SUVmax) of the initial image (SUV1) and SUVmax of the delayed image (SUV2) were determined, and the retention index (RI) was calculated by dividing the difference between SUV2 and SUV1 by SUV1 (i.e., RI = [SUV2 - SUV1]/SUV1 × 100). These indices were compared between patient groups that were proven to have pathologically benign or malignant thyroid lesions. There was no statistically significant difference in SUV1 between benign and malignant lesions. SUV2 and RI of the malignant lesions were significantly higher than the benign lesions. The areas under the ROC curves showed that SUV2 and RI have the ability to discriminate between benign and malignant thyroid lesions. The predictability of dual-time-point PET parameters for thyroid malignancy was assessed by ROC curve analyses. When SUV2 of 3.9 was used as cut-off threshold, malignancy on the pathology could be predicted with a sensitivity of 87.5 % and specificity of 75 %. A thyroid lesion that shows RI greater than 12.5 % could be expected to be malignant (sensitivity 88.9 %, specificity 66.3 %). All malignant lesions showed an increase in SUVmax on the delayed images compared with the initial images. But in the group of benign lesions, 37.5 % (6/16) showed a decrease or no change in SUVmax. Dual-time-point F-FDG PET/CT, obtaining additional images 2 h after injection, seems to be a complementary method for the differentiation between malignancy and benignity of incidental thyroid lesions. [ABSTRACT FROM AUTHOR]

Aim: The aim of this study was to prove the diagnostic value of interim 18F-Fluorodeoxyglucose-positron-emission tomography combined with computed tomography (PET/CT) scan for predicting pathological complete response (pCR) compared to other factors in neoadjuvant chemotherapy., Patients and Methods: Twenty-seven patients with breast cancer were included in this retrospective study. They all underwent scheduled neoadjuvant chemotherapy. Patients underwent PET/CT at baseline, mid-point (interim), and preoperatively (after completion of chemotherapy). The metabolic response was calculated as follows: ΔStandardized uptake value (SUV)(%)=(1st SUV(max)-2nd SUV(max))/1st SUV(max) × 100., Results: The change in SUVmax between baseline and interim PET/CT scans was significantly larger than between interim and preoperative PET/CT scan. An optimal cut-off ΔSUV value of 78.3% was proposed for discriminating patients with pCR from those without pCR. Metabolic CR, defined as a change of SUV(max) greater than the cut-off value, can predict pCR according to univariate analysis (p=0.012; Relative risk (RR)=25.3). Furthermore, metabolic CR was the most powerful factor for predicting pCR than other possible factors according to multivariate analysis (p=0.003)., Conclusion: It is possible to use interim (18)F-FDG PET-CT as an effective method to predict early response in patients with breast cancer treated with neoadjuvant chemotherapy., (Copyright© 2014 International Institute of Anticancer Research (Dr. John G. Delinassios), All rights reserved.)