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2. Macrotrabecular-Massive Hepatocellular Carcinoma: Light and Shadow in Current Knowledge

Author

Sessa A, Mulé S, Brustia R, Regnault H, Galletto Pregliasco A, Rhaiem R, Leroy V, Sommacale D, Luciani A, Calderaro J, and Amaddeo G

Subjects
hepatocellular carcinoma, macrotrabecular, angiopoietin 2 inhibitors, tp53, immunotherapy, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282
Abstract

Anna Sessa,1– 3 Sébastien Mulé,2– 4 Raffaele Brustia,2,3,5 Hélène Regnault,1,3 Athena Galletto Pregliasco,4 Rami Rhaiem,6,7 Vincent Leroy,1– 3 Daniele Sommacale,2,3,5 Alain Luciani,2– 4 Julien Calderaro,2,3,8 Giuliana Amaddeo1– 3 1Hepatology Department, APHP, Henri Mondor University Hospital, Créteil, France; 2Université Paris-Est Créteil, Faculté de Médecine, Créteil, France; 3Inserm, U955, Team 18, Créteil, France; 4Medical Imaging Department, AP-HP, Henri Mondor University Hospital, Créteil, France; 5Department of Digestive and Hepato-Pancreato-Biliary Surgery, AP-HP, Henri Mondor University Hospital, Créteil, France; 6Department of Hepato-Biliary Pancreatic and Digestive Oncological Surgery, Robert Debré University Hospital, Reims, France; 7Reims Champagne-Ardenne University, Reims, France; 8Department of Pathology, APHP, Henri Mondor University Hospital, Créteil, FranceCorrespondence: Giuliana Amaddeo; Anna Sessa, Hepatology Department, APHP, Henri Mondor University Hospital, 1 rue Gustave Eiffel, Créteil, 94000, France, Tel +33 149812353, Email giuliana.amaddeo@aphp.fr; asessa1990@gmail.comAbstract: The subject of this narrative review is macrotrabecular-massive hepatocellular carcinoma (MTM‐HCC). Despite their rarity, these tumours are of general interest because of their epidemiological and clinical features and for representing a distinct model of the interaction between the angiogenetic system and neoplastic cells. The MTM‐HCC subtype is associated with various adverse biological and pathological parameters (the Alfa-foetoprotein (AFP) serum level, tumour size, vascular invasion, and satellite nodules) and is a key determinant of patient prognosis, with a strong and independent predictive value for early and overall tumour recurrence. Gene expression profiling has demonstrated that angiogenesis activation is a hallmark feature of MTM-HCC, with overexpression of both angiopoietin 2 (ANGPT2) and vascular endothelial growth factor A (VEGFA).Keywords: hepatocellular carcinoma, macrotrabecular, angiopoietin 2 inhibitors, TP53, immunotherapy

Published
2022

9. Clinical features and outcomes of patients with pancreatic cancer requiring unplanned medical ICU admission: A retrospective multicenter study

Author

Kemoun, G., primary, Weiss, E., additional, El Houari, L., additional, Bonny, V., additional, Goury, A., additional, Caliez, O., additional, Picard, B., additional, Rudler, M., additional, Rhaiem, R., additional, Rebours, V., additional, Mayaux, J., additional, Bachet, J.B., additional, Belin, L., additional, Demoule, A., additional, and Decavèle, M., additional

Published
2023
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14. 2020 WSES guidelines for the detection and management of bile duct injury during cholecystectomy

Author

De'Angelis, N, Catena, F, Memeo, R, Coccolini, F, Martinez-Perez, A, Romeo, O, De Simone, B, Di Saverio, S, Brustia, R, Rhaiem, R, Piardi, T, Conticchio, M, Marchegiani, F, Beghdadi, N, Abu-Zidan, F, Alikhanov, R, Allard, M, Allievi, N, Amaddeo, G, Ansaloni, L, Andersson, R, Andolfi, E, Azfar, M, Bala, M, Benkabbou, A, Ben-Ishay, O, Bianchi, G, Biffl, W, Brunetti, F, Carra, M, Casanova, D, Celentano, V, Ceresoli, M, Chiara, O, Cimbanassi, S, Bini, R, Coimbra, R, Luigi de'Angelis, G, Decembrino, F, De Palma, A, de Reuver, P, Domingo, C, Cotsoglou, C, Ferrero, A, Fraga, G, Gaiani, F, Gheza, F, Gurrado, A, Harrison, E, Henriquez, A, Hofmeyr, S, Iadarola, R, Kashuk, J, Kianmanesh, R, Kirkpatrick, A, Kluger, Y, Landi, F, Langella, S, Lapointe, R, Le Roy, B, Luciani, A, Machado, F, Maggi, U, Maier, R, Mefire, A, Hiramatsu, K, Ordonez, C, Patrizi, F, Planells, M, Peitzman, A, Pekolj, J, Perdigao, F, Pereira, B, Pessaux, P, Pisano, M, Puyana, J, Rizoli, S, Portigliotti, L, Romito, R, Sakakushev, B, Sanei, B, Scatton, O, Serradilla-Martin, M, Schneck, A, Sissoko, M, Sobhani, I, ten Broek, R, Testini, M, Valinas, R, Veloudis, G, Vitali, G, Weber, D, Zorcolo, L, Giuliante, F, Gavriilidis, P, Fuks, D, Sommacale, D, de'Angelis N., Catena F., Memeo R., Coccolini F., Martinez-Perez A., Romeo O. M., De Simone B., Di Saverio S., Brustia R., Rhaiem R., Piardi T., Conticchio M., Marchegiani F., Beghdadi N., Abu-Zidan F. M., Alikhanov R., Allard M. -A., Allievi N., Amaddeo G., Ansaloni L., Andersson R., Andolfi E., Azfar M., Bala M., Benkabbou A., Ben-Ishay O., Bianchi G., Biffl W. L., Brunetti F., Carra M. C., Casanova D., Celentano V., Ceresoli M., Chiara O., Cimbanassi S., Bini R., Coimbra R., Luigi de'Angelis G., Decembrino F., De Palma A., de Reuver P. R., Domingo C., Cotsoglou C., Ferrero A., Fraga G. P., Gaiani F., Gheza F., Gurrado A., Harrison E., Henriquez A., Hofmeyr S., Iadarola R., Kashuk J. L., Kianmanesh R., Kirkpatrick A. W., Kluger Y., Landi F., Langella S., Lapointe R., Le Roy B., Luciani A., Machado F., Maggi U., Maier R. V., Mefire A. C., Hiramatsu K., Ordonez C., Patrizi F., Planells M., Peitzman A. B., Pekolj J., Perdigao F., Pereira B. M., Pessaux P., Pisano M., Puyana J. C., Rizoli S., Portigliotti L., Romito R., Sakakushev B., Sanei B., Scatton O., Serradilla-Martin M., Schneck A. -S., Sissoko M. L., Sobhani I., ten Broek R. P., Testini M., Valinas R., Veloudis G., Vitali G. C., Weber D., Zorcolo L., Giuliante F., Gavriilidis P., Fuks D., Sommacale D., De'Angelis, N, Catena, F, Memeo, R, Coccolini, F, Martinez-Perez, A, Romeo, O, De Simone, B, Di Saverio, S, Brustia, R, Rhaiem, R, Piardi, T, Conticchio, M, Marchegiani, F, Beghdadi, N, Abu-Zidan, F, Alikhanov, R, Allard, M, Allievi, N, Amaddeo, G, Ansaloni, L, Andersson, R, Andolfi, E, Azfar, M, Bala, M, Benkabbou, A, Ben-Ishay, O, Bianchi, G, Biffl, W, Brunetti, F, Carra, M, Casanova, D, Celentano, V, Ceresoli, M, Chiara, O, Cimbanassi, S, Bini, R, Coimbra, R, Luigi de'Angelis, G, Decembrino, F, De Palma, A, de Reuver, P, Domingo, C, Cotsoglou, C, Ferrero, A, Fraga, G, Gaiani, F, Gheza, F, Gurrado, A, Harrison, E, Henriquez, A, Hofmeyr, S, Iadarola, R, Kashuk, J, Kianmanesh, R, Kirkpatrick, A, Kluger, Y, Landi, F, Langella, S, Lapointe, R, Le Roy, B, Luciani, A, Machado, F, Maggi, U, Maier, R, Mefire, A, Hiramatsu, K, Ordonez, C, Patrizi, F, Planells, M, Peitzman, A, Pekolj, J, Perdigao, F, Pereira, B, Pessaux, P, Pisano, M, Puyana, J, Rizoli, S, Portigliotti, L, Romito, R, Sakakushev, B, Sanei, B, Scatton, O, Serradilla-Martin, M, Schneck, A, Sissoko, M, Sobhani, I, ten Broek, R, Testini, M, Valinas, R, Veloudis, G, Vitali, G, Weber, D, Zorcolo, L, Giuliante, F, Gavriilidis, P, Fuks, D, Sommacale, D, de'Angelis N., Catena F., Memeo R., Coccolini F., Martinez-Perez A., Romeo O. M., De Simone B., Di Saverio S., Brustia R., Rhaiem R., Piardi T., Conticchio M., Marchegiani F., Beghdadi N., Abu-Zidan F. M., Alikhanov R., Allard M. -A., Allievi N., Amaddeo G., Ansaloni L., Andersson R., Andolfi E., Azfar M., Bala M., Benkabbou A., Ben-Ishay O., Bianchi G., Biffl W. L., Brunetti F., Carra M. C., Casanova D., Celentano V., Ceresoli M., Chiara O., Cimbanassi S., Bini R., Coimbra R., Luigi de'Angelis G., Decembrino F., De Palma A., de Reuver P. R., Domingo C., Cotsoglou C., Ferrero A., Fraga G. P., Gaiani F., Gheza F., Gurrado A., Harrison E., Henriquez A., Hofmeyr S., Iadarola R., Kashuk J. L., Kianmanesh R., Kirkpatrick A. W., Kluger Y., Landi F., Langella S., Lapointe R., Le Roy B., Luciani A., Machado F., Maggi U., Maier R. V., Mefire A. C., Hiramatsu K., Ordonez C., Patrizi F., Planells M., Peitzman A. B., Pekolj J., Perdigao F., Pereira B. M., Pessaux P., Pisano M., Puyana J. C., Rizoli S., Portigliotti L., Romito R., Sakakushev B., Sanei B., Scatton O., Serradilla-Martin M., Schneck A. -S., Sissoko M. L., Sobhani I., ten Broek R. P., Testini M., Valinas R., Veloudis G., Vitali G. C., Weber D., Zorcolo L., Giuliante F., Gavriilidis P., Fuks D., and Sommacale D.

Abstract

Bile duct injury (BDI) is a dangerous complication of cholecystectomy, with significant postoperative sequelae for the patient in terms of morbidity, mortality, and long-term quality of life. BDIs have an estimated incidence of 0.4–1.5%, but considering the number of cholecystectomies performed worldwide, mostly by laparoscopy, surgeons must be prepared to manage this surgical challenge. Most BDIs are recognized either during the procedure or in the immediate postoperative period. However, some BDIs may be discovered later during the postoperative period, and this may translate to delayed or inappropriate treatments. Providing a specific diagnosis and a precise description of the BDI will expedite the decision-making process and increase the chance of treatment success. Subsequently, the choice and timing of the appropriate reconstructive strategy have a critical role in long-term prognosis. Currently, a wide spectrum of multidisciplinary interventions with different degrees of invasiveness is indicated for BDI management. These World Society of Emergency Surgery (WSES) guidelines have been produced following an exhaustive review of the current literature and an international expert panel discussion with the aim of providing evidence-based recommendations to facilitate and standardize the detection and management of BDIs during cholecystectomy. In particular, the 2020 WSES guidelines cover the following key aspects: (1) strategies to minimize the risk of BDI during cholecystectomy; (2) BDI rates in general surgery units and review of surgical practice; (3) how to classify, stage, and report BDI once detected; (4) how to manage an intraoperatively detected BDI; (5) indications for antibiotic treatment; (6) indications for clinical, biochemical, and imaging investigations for suspected BDI; and (7) how to manage a postoperatively detected BDI.

Published
2021

15. Long-Term Outcomes of Perioperative Versus Neoadjuvant Chemotherapy for Resectable Colorectal Liver Metastases: An International Multicentre Propensity-Score Matched Analysis with Stratification by Contemporary Risk-Scoring

Author

Di Martino M, Primavesi F, Syn N, Dorcaratto D, de la Hoz Rodriguez A, Dupre A, Piardi T, Rhaiem R, Blanco Fernandez G, de Armas Conde N, Rodriguez Sanjuan J, Fernandez Santiago R, Fernandez-Moreno M, Ferret G, Lopez Ben S, Suarez Munoz M, Perez-Alonso A, Koh Y, Jones R, and Martin-Perez E

Abstract

BACKGROUND: There is still debate regarding the principal role and ideal timing of perioperative chemotherapy (CTx) for patients with upfront resectable colorectal liver metastases (CRLM). This study assesses long-term oncological outcomes in patients receiving neoadjuvant CTx only versus those receiving neoadjuvant combined with adjuvant therapy (perioperative CTx).; METHODS: International multicentre retrospective analysis of patients with CRLM undergoing liver resection between 2010 and 2015. Characteristics and outcomes were compared before and after propensity score matching (PSM). Primary endpoints were long-term oncological outcomes, such as recurrence-free survival (RFS) and overall survival (OS). Furthermore, stratification by the tumour burden score (TBS) was applied.; RESULTS: Of 967 patients undergoing hepatectomy, 252 were analysed, with a median follow-up of 45 months. The unmatched comparison revealed a bias towards patients with neoadjuvant CTx presenting with more high-risk patients (p = 0.045) and experiencing increased postoperative complications =Clavien-Dindo III (20.9% vs. 8%, p = 0.003). Multivariable analysis showed that perioperative CTx was associated with significantly improved RFS (hazard ratio [HR] 0.579, 95% confidence interval [CI] 0.420-0.800, p = 0.001) and OS (HR 0.579, 95% CI 0.403-0.834, p = 0.003). After PSM (n = 180 patients), the two groups were comparable regarding baseline characteristics. The perioperative CTx group presented with a significantly prolonged RFS (HR 0.53, 95% CI 0.37-0.76, p = 0.007) and OS (HR 0.58, 95% CI 0.38-0.87, p = 0.010) in both low and high TBS patients.; CONCLUSIONS: When patients after resection of CRLM are able to tolerate additional postoperative CTx, a perioperative strategy demonstrates increased RFS and OS in comparison with neoadjuvant CTx only in both low and high-risk situations. © 2022. Society of Surgical Oncology.

Published
2022

16. ASO Visual Abstract: Long-Term Outcomes of Perioperative versus Neoadjuvant Chemotherapy for Resectable Colorectal Liver Metastases-An International Multicenter Propensity-Score Matched Analysis with Stratification by Contemporary Risk Scoring

Author

Di Martino M, Primavesi F, Syn N, Dorcaratto D, de la Hoz Rodriguez A, Dupre A, Piardi T, Rhaiem R, Blanco Fernandez G, de Armas Conde N, Rodriguez Sanjuan J, Fernandez Santiago R, Fernandez-Moreno M, Ferret G, Lopez Ben S, Suarez Munoz M, Perez-Alonso A, Koh Y, Jones R, and Martin-Perez E

Published
2022

23. A familial TSC1 exon 5 microdeletion associated with angiolipomas and renal-cell carcinoma: A mTORopathy Tunisian familial pedigree

Author

Bouayed Abdelmoula, N., primary, Abdelmoula, B., additional, Masmoudi, I., additional, Bouaziz, I., additional, Dhouib, R., additional, Sallemi, S., additional, Keskes, M., additional, Sehli, M., additional, Chaabouni, K., additional, Falleh, S., additional, Medhioub, A., additional, Khelfi, K., additional, Rhaiem, R., additional, Khouaja, E., additional, Norddine, I., additional, Boukthir, N., additional, Louati, R., additional, Abdellaoui, N., additional, Kaabi, O., additional, Chaker, K., additional, Aloulou, S., additional, and Smaoui, W., additional

Published
2021
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24. Perioperative chemotherapy versus surgery alone for resectable colorectal liver metastases: an international multicentre propensity score matched analysis on long-term outcomes according to established prognostic risk scores

Author

Di Martino M, Primavesi F, Syn N, Dorcaratto D, de la Hoz Rodriguez A, Dupre A, Piardi T, Rhaiem R, Blanco Fernandez G, Prada Villaverde A, Rodriguez Sanjuan J, Fernandez Santiago R, Fernandez-Moreno M, Ferret G, Lopez Ben S, Suarez Munoz M, Perez-Alonso A, Koh Y, Jones R, and Martin-Perez E

Abstract

BACKGROUND: There is still uncertainty regarding the role of perioperative chemotherapy (CTx) in patients with resectable colorectal liver metastases (CRLM), especially in those with a low-risk of recurrence. METHODS: Multicentre retrospective analysis of patients with CRLM undergoing liver resection between 2010-2015. Patients were divided into two groups according to whether they received perioperative CTx or not and were compared using propensity score matching (PSM) analysis. Then, they were stratified according to prognostic risk scores, including: Clinical Risk Score (CRS), Tumour Burden Score (TBS) and Genetic And Morphological Evaluation (GAME) score. RESULTS: The study included 967 patients with a median follow-up of 68 months. After PSM analysis, patients with perioperative CTx presented prolonged overall survival (OS) in comparison with the surgery alone group (82.8 vs 52.5 months, p = 0.017). On multivariable analysis perioperative CTx was an independent predictor of increased OS (HR 0.705, 95%CI 0.705-0.516, p = 0.029). The benefits of perioperative CTx on survival were confirmed in patients with CRS and TBS scores =2 (p = 0.022 and p = 0.020, respectively) and in patients with a GAME score =1 (p = 0.006). CONCLUSION: Perioperative CTx demonstrated an increase in OS in patients with CRLM. Patients with a low-risk of recurrence seem to benefit from systemic treatment.

Published
2021

25. 2020 WSES guidelines for the detection and management of bile duct injury during cholecystectomy

Author

De'Angelis, N., Catena, F., Memeo, R., Coccolini, F., Martínez-Pérez, A., Romeo, O.M., Simone, B. De, Saverio, S. Di, Brustia, R., Rhaiem, R., Piardi, T., Conticchio, M., Marchegiani, F., Beghdadi, N., Abu-Zidan, F.M., Alikhanov, R., Allard, M.A., Allievi, N., Amaddeo, G., Ansaloni, L., Andersson, R., Andolfi, E., Azfar, M., Bala, M., Benkabbou, A., Ben-Ishay, O., Bianchi, G., Biffl, W.L., Brunetti, F., Carra, M.C., Casanova, D., Celentano, V., Ceresoli, M., Chiara, O., Cimbanassi, S., Bini, R., Coimbra, R., de'Angelis, G. Luigi, Decembrino, F., Palma, A., Reuver, P.R. de, Domingo, C., Cotsoglou, C., Ferrero, A., Fraga, G.P., Gaiani, F., Gheza, F., Gurrado, A., Harrison, E., Henriquez, A., Hofmeyr, S., Iadarola, R., Kashuk, J.L., Kianmanesh, R., Kirkpatrick, A.W., Kluger, Y., Landi, F., Langella, S., Lapointe, R., Roy, B., Luciani, A., Machado, F., Maggi, U., Maier, R.V., Mefire, A.C., Hiramatsu, K., Ordoñez, C., Patrizi, F., Planells, M., Peitzman, A.B., Pekolj, J., Perdigao, F., Pereira, B.M., Pessaux, P., Pisano, M., Puyana, J.C., Rizoli, S., Portigliotti, L., Romito, R., Sakakushev, B., Sanei, B., Scatton, O., Serradilla-Martin, M., Schneck, A.S., Sissoko, M.L., Sobhani, I., Broek, R.P. Ten, Testini, M., Valinas, R., Veloudis, G., Vitali, G.C., Weber, D., Zorcolo, L., Giuliante, F., Gavriilidis, P., Fuks, D., Sommacale, D., De'Angelis, N., Catena, F., Memeo, R., Coccolini, F., Martínez-Pérez, A., Romeo, O.M., Simone, B. De, Saverio, S. Di, Brustia, R., Rhaiem, R., Piardi, T., Conticchio, M., Marchegiani, F., Beghdadi, N., Abu-Zidan, F.M., Alikhanov, R., Allard, M.A., Allievi, N., Amaddeo, G., Ansaloni, L., Andersson, R., Andolfi, E., Azfar, M., Bala, M., Benkabbou, A., Ben-Ishay, O., Bianchi, G., Biffl, W.L., Brunetti, F., Carra, M.C., Casanova, D., Celentano, V., Ceresoli, M., Chiara, O., Cimbanassi, S., Bini, R., Coimbra, R., de'Angelis, G. Luigi, Decembrino, F., Palma, A., Reuver, P.R. de, Domingo, C., Cotsoglou, C., Ferrero, A., Fraga, G.P., Gaiani, F., Gheza, F., Gurrado, A., Harrison, E., Henriquez, A., Hofmeyr, S., Iadarola, R., Kashuk, J.L., Kianmanesh, R., Kirkpatrick, A.W., Kluger, Y., Landi, F., Langella, S., Lapointe, R., Roy, B., Luciani, A., Machado, F., Maggi, U., Maier, R.V., Mefire, A.C., Hiramatsu, K., Ordoñez, C., Patrizi, F., Planells, M., Peitzman, A.B., Pekolj, J., Perdigao, F., Pereira, B.M., Pessaux, P., Pisano, M., Puyana, J.C., Rizoli, S., Portigliotti, L., Romito, R., Sakakushev, B., Sanei, B., Scatton, O., Serradilla-Martin, M., Schneck, A.S., Sissoko, M.L., Sobhani, I., Broek, R.P. Ten, Testini, M., Valinas, R., Veloudis, G., Vitali, G.C., Weber, D., Zorcolo, L., Giuliante, F., Gavriilidis, P., Fuks, D., and Sommacale, D.

Abstract

Contains fulltext : 238974.pdf (Publisher’s version ) (Open Access), Bile duct injury (BDI) is a dangerous complication of cholecystectomy, with significant postoperative sequelae for the patient in terms of morbidity, mortality, and long-term quality of life. BDIs have an estimated incidence of 0.4-1.5%, but considering the number of cholecystectomies performed worldwide, mostly by laparoscopy, surgeons must be prepared to manage this surgical challenge. Most BDIs are recognized either during the procedure or in the immediate postoperative period. However, some BDIs may be discovered later during the postoperative period, and this may translate to delayed or inappropriate treatments. Providing a specific diagnosis and a precise description of the BDI will expedite the decision-making process and increase the chance of treatment success. Subsequently, the choice and timing of the appropriate reconstructive strategy have a critical role in long-term prognosis. Currently, a wide spectrum of multidisciplinary interventions with different degrees of invasiveness is indicated for BDI management. These World Society of Emergency Surgery (WSES) guidelines have been produced following an exhaustive review of the current literature and an international expert panel discussion with the aim of providing evidence-based recommendations to facilitate and standardize the detection and management of BDIs during cholecystectomy. In particular, the 2020 WSES guidelines cover the following key aspects: (1) strategies to minimize the risk of BDI during cholecystectomy; (2) BDI rates in general surgery units and review of surgical practice; (3) how to classify, stage, and report BDI once detected; (4) how to manage an intraoperatively detected BDI; (5) indications for antibiotic treatment; (6) indications for clinical, biochemical, and imaging investigations for suspected BDI; and (7) how to manage a postoperatively detected BDI.

Published
2021

39. Eating disorder and bipolar mental illness through genome wide association studies.

Author

Abdelmoula, B., Rhaiem, R., Charfi, A., Kotti, S., Masmoudi, I., Marsaoui, Y., and Bouayed Abdelmoula, N.

Subjects
*GENOME-wide association studies, *EATING disorders, *BIPOLAR disorder, *COMPULSIVE eating, *BULIMIA
Abstract

Introduction: Besides the role played by environmental factors and their epigenetic influences, scientific researchers showed that the susceptibility to develop an eating disorder among bipolar people is due to genetic factors. Objectives: To review the genetic factors behind eating disorders, highlight the role of genetics and epigenetics in the comorbidity of bipolar and eating disorders. Methods: To delineate the role of genetics and epigenetics in eating disorders and bipolar disorders as two related mental illness, we comprehensively reviewed the scientific literature using GWAS (genome wide association studies) catalog databases to find genome-wide association studies carried out on patients with bipolar disorder EFO_0005203 and eating disorder comorbid condition (anorexia nervosa, binge eating, bulimia nervosa) EFO_0005203. Results: GWAS of eating disorders were found in 33 studies with 324 associations whereas those of bipolar disorder were found in 114 studies with 1469 associations. GWAS of eating disorders within bipolar disorders revealed 182 and 134 associations, as well as 10 and 8 publications respectively. Only anorexia nervosa and binge eating were studied in association with bipolar disorders. The genetic variants were protein coding genes (CUBN, FAM228B, FXR1, etc.), non-coding RNA genes (SOX2-OT, MMADHC-DT, etc.), and pseudo-genes (RNU1-23P, CACYBPP2, etc.). Conclusions: About 300 genetic variants are associated with eating disorder as a comorbid condition of bipolar disorders. These variants may play a crucial role in the causes and mechanisms of eating disorders and should be more investigated towards more precise clinical and genetic entities. Disclosure of Interest: None Declared [ABSTRACT FROM AUTHOR]

Published
2024
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44. A Rare Complication of Gastrojejunostomy: Jejunogastric Intussusceptions

Author

Ben Safta Z, Rhaiem R, Kellil T, and Wael Rebai

Subjects
medicine.medical_specialty, Jejunogastric intussusception, business.industry, medicine.medical_treatment, General surgery, 030230 surgery, Bioinformatics, 03 medical and health sciences, 0302 clinical medicine, 030220 oncology & carcinogenesis, medicine, Gastrectomy, Ct findings, Complication, business
Abstract

Jejunogastric intussusception (JGI) is a rare life-threatening complication of gastrectomy or gastrojejunostomy. Diagnosis of this condition has been reported to be difficult in most of the cases. An early diagnosis and urgent surgical intervention are essential to avoid mortality. We present a case of the characteristic US and CT findings of this entity.

Published
2017

45. Simultaneous Cecal and Sigmoid Volvulus: A Rare Cause of Intestinal Obstruction

Author

Daghfous A, Ben Safta Z, Amine Makni, R. Ksantini, Masmoudi W, Montasser Kacem, Wael Rebai, Kellil T, Faouzi Chebbi, Juini M, and Rhaiem R

Subjects
medicine.medical_specialty, integumentary system, Cecal volvulus, business.industry, Sigmoid colon, 030230 surgery, medicine.disease, Bioinformatics, digestive system, Gastroenterology, digestive system diseases, Sigmoid colon volvulus, 030218 nuclear medicine & medical imaging, Volvulus, 03 medical and health sciences, Cecum, 0302 clinical medicine, medicine.anatomical_structure, Internal medicine, parasitic diseases, medicine, Sigmoid volvulus, skin and connective tissue diseases, business, Colonic volvulus
Abstract

Volvulus is a rare cause of intestinal obstruction. The main types of colonic volvulus are sigmoid volvulus and cecal volvulus. The simultaneous occurrence of cecal and sigmoid colon volvulus is extremely unusual. To our knowledge, few reports on simultaneous sigmoid and cecum colon have been published to date. We are reporting a case of a synchronous volvulus of ceacum and sigmoid colon.

Published
2017

46. Primary hydatid cyst of the pancreas

Author

Rhaiem, R., primary, Maghrebi, H., additional, Fteriche, F.S., additional, Haddad, A., additional, Makni, A., additional, Daghfous, A., additional, Ksantini, R., additional, and Ben Safta, Z., additional

Published
2018
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