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26 results on '"Rezvan, Ali"'

1. Identification of a clinically efficacious CAR T cell subset in diffuse large B cell lymphoma by dynamic multidimensional single-cell profiling

Author

Rezvan, Ali, Romain, Gabrielle, Fathi, Mohsen, Heeke, Darren, Martinez-Paniagua, Melisa, An, Xingyue, Bandey, Irfan N., Montalvo, Melisa J., Adolacion, Jay R. T., Saeedi, Arash, Sadeghi, Fatemeh, Fousek, Kristen, Puebla-Osorio, Nahum, Cooper, Laurence J. N., Bernatchez, Chantale, Singh, Harjeet, Ahmed, Nabil, Mattie, Mike, Bot, Adrian, Neelapu, Sattva, and Varadarajan, Navin

Published
2024
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4. Author Correction: Identification of a clinically efficacious CAR T cell subset in diffuse large B cell lymphoma by dynamic multidimensional single-cell profiling

Author

Rezvan, Ali, Romain, Gabrielle, Fathi, Mohsen, Heeke, Darren, Martinez-Paniagua, Melisa, An, Xingyue, Bandey, Irfan N., Montalvo, Melisa J., Adolacion, Jay R. T., Saeedi, Arash, Sadeghi, Fatemeh, Fousek, Kristen, Puebla-Osorio, Nahum, Cooper, Laurence J. N., Bernatchez, Chantale, Singh, Harjeet, Ahmed, Nabil, Mattie, Mike, Bot, Adrian, Neelapu, Sattva, and Varadarajan, Navin

Published
2024
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5. Author Correction: KIR-based inhibitory CARs overcome CAR-NK cell trogocytosis-mediated fratricide and tumor escape

Author

Li, Ye, Basar, Rafet, Wang, Guohui, Liu, Enli, Moyes, Judy S., Li, Li, Kerbauy, Lucila N., Uprety, Nadima, Fathi, Mohsen, Rezvan, Ali, Banerjee, Pinaki P., Muniz-Feliciano, Luis, Laskowski, Tamara J., Ensley, Emily, Daher, May, Shanley, Mayra, Mendt, Mayela, Acharya, Sunil, Liu, Bin, Biederstädt, Alexander, Rafei, Hind, Guo, Xingliang, Melo Garcia, Luciana, Lin, Paul, Ang, Sonny, Marin, David, Chen, Ken, Bover, Laura, Champlin, Richard E., Varadarajan, Navin, Shpall, Elizabeth J., and Rezvani, Katayoun

Published
2024
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6. KIR-based inhibitory CARs overcome CAR-NK cell trogocytosis-mediated fratricide and tumor escape

Author

Li, Ye, Basar, Rafet, Wang, Guohui, Liu, Enli, Moyes, Judy S., Li, Li, Kerbauy, Lucila N., Uprety, Nadima, Fathi, Mohsen, Rezvan, Ali, Banerjee, Pinaki P., Muniz-Feliciano, Luis, Laskowski, Tamara J., Ensley, Emily, Daher, May, Shanley, Mayra, Mendt, Mayela, Acharya, Sunil, Liu, Bin, Biederstädt, Alexander, Rafei, Hind, Guo, Xingliang, Melo Garcia, Luciana, Lin, Paul, Ang, Sonny, Marin, David, Chen, Ken, Bover, Laura, Champlin, Richard E., Varadarajan, Navin, Shpall, Elizabeth J., and Rezvani, Katayoun

Published
2022
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9. Targeting a cytokine checkpoint enhances the fitness of armored cord blood CAR-NK cells

Author

Daher, May, Basar, Rafet, Gokdemir, Elif, Baran, Natalia, Uprety, Nadima, Nunez Cortes, Ana Karen, Mendt, Mayela, Kerbauy, Lucila Nassif, Banerjee, Pinaki P., Shanley, Mayra, Imahashi, Nobuhiko, Li, Li, Lim, Francesca Lorraine Wei Inng, Fathi, Mohsen, Rezvan, Ali, Mohanty, Vakul, Shen, Yifei, Shaim, Hila, Lu, Junjun, Ozcan, Gonca, Ensley, Emily, Kaplan, Mecit, Nandivada, Vandana, Bdiwi, Mustafa, Acharya, Sunil, Xi, Yuanxin, Wan, Xinhai, Mak, Duncan, Liu, Enli, Jiang, Xin Ru, Ang, Sonny, Muniz-Feliciano, Luis, Li, Ye, Wang, Jing, Kordasti, Shahram, Petrov, Nedyalko, Varadarajan, Navin, Marin, David, Brunetti, Lorenzo, Skinner, Richard J., Lyu, Shangrong, Silva, Leiser, Turk, Rolf, Schubert, Mollie S., Rettig, Garrett R., McNeill, Matthew S., Kurgan, Gavin, Behlke, Mark A., Li, Heng, Fowlkes, Natalie W., Chen, Ken, Konopleva, Marina, Champlin, Richard E., Shpall, Elizabeth J., and Rezvani, Katayoun

Published
2021
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10. Multidimensional single-cell analysis identifies a role for CD2-CD58 interactions in clinical antitumor T cell responses

Author

Romain, Gabrielle, Strati, Paolo, Rezvan, Ali, Fathi, Mohsen, Bandey, Irfan N., Adolacion, Jay R.T., Heeke, Darren, Liadi, Ivan, Marques-Piubelli, Mario L., Solis, Luisa M., Mahendra, Ankit, Vega, Francisco, Cooper, Laurence J.N., Singh, Harjeet, Mattie, Mike, Bot, Adrian, Neelapu, Sattva S., and Varadarajan, Navin

Subjects
T cells -- Physiological aspects -- Health aspects, Immune response -- Health aspects, Lymphomas -- Drug therapy -- Development and progression, Cancer -- Care and treatment, Cell adhesion molecules -- Physiological aspects -- Health aspects, Health care industry
Abstract

The in vivo persistence of adoptively transferred T cells is predictive of antitumor response. Identifying functional properties of infused T cells that lead to in vivo persistence and tumor eradication has remained elusive. We profiled CD19-specific chimeric antigen receptor (CAR) T cells as the infusion products used to treat large B cell lymphomas using high-throughput single-cell technologies based on time-lapse imaging microscopy in nanowell grids (TIMING), which integrates killing, cytokine secretion, and transcriptional profiling. Our results show that the directional migration of CD19-specific CAR T cells is correlated with multifunctionality. We showed that CD2 on T cells is associated with directional migration and that the interaction between CD2 on T cells and CD58 on lymphoma cells accelerates killing and serial killing. Consistent with this, we observed that elevated CD58 expression on pretreatment tumor samples in patients with relapsed or refractory large B cell lymphomas treated with CD19-specific CAR T cell therapy was associated with complete clinical response and survival. These results highlight the importance of studying dynamic T cell-tumor cell interactions in identifying optimal antitumor responses., Introduction T cells stably endowed with a genetically encoded chimeric antigen receptor (CAR) targeting CD19 have shown clinical responses in refractory B-lineage leukemias and lymphomas. The potential for durable remissions [...]

Published
2022
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12. Metabolic plasticity of T-cell therapies: multi-omic profiling of interacting human tumor-infiltrating lymphocytes and autologous tumor adoptive cell therapy

Author

Martinez-Paniagua, Melisa, primary, Haymaker, Cara, additional, Robinson, Jonathan, additional, Harel, Michal, additional, Creasy, Caitlin, additional, Adolacion, Jay R T., additional, An, Xingyue, additional, Fathi, Mohsen, additional, Rezvan, Ali, additional, Kumar, Monish, additional, Amritkar, Amit, additional, Woodman, Scott E., additional, Amaria, Rodabe N., additional, Geiger, Tamar, additional, Hwu, Patrick, additional, Bernatchez, Chantale, additional, and Varadarajan, Navin, additional

Published
2022
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15. Ending transmission of SARS-CoV-2: sterilizing immunity using an intranasal subunit vaccine

Author

Leekha, Ankita, primary, Saeedi, Arash, additional, Sefat, Samiur Rahman, additional, Kumar, Monish, additional, Paniagua, Melisa Martinez, additional, Damian, Adrian, additional, Kulkarni, Rohan, additional, Rezvan, Ali, additional, Mosoumi, Shalaleh, additional, Liu, Xinli, additional, Cooper, Laurence J.N., additional, Sebastian, Manu, additional, Hurst, Brett L., additional, and Varadarajan, Navin, additional

Published
2022
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16. T-cell potential for CD19-expressing malignancies revealed by multi-dimensional single-cell profiling

Author

Rezvan, Ali, primary, Romain, Garbrielle, additional, Fathi, Mohsen, additional, Heeke, Darren, additional, Martinez-Paniagua, Melisa, additional, An, Xingyue, additional, Bandey, Irfan N, additional, Saeedi, Arash, additional, Sadeghi, Fatemeh, additional, Fousek, Kristen, additional, Puebla-Osorio, Nahum, additional, Cooper, Laurence JN, additional, Bernatchez, Chantale, additional, Singh, Harjeet, additional, Ahmed, Nabil, additional, Mattie, Mike, additional, Bot, Adrian, additional, Neelapu, Sattva, additional, and Varadarajan, Navin, additional

Published
2022
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17. Multiomic dynamic single-cell profiling of CAR T cell populations associated with efficacy

Author

Rezvan, Ali, primary, Romain, Gabrielle, additional, Fathi, Mohsen, additional, Heeke, Darren, additional, Martinez-Paniagua, Melisa, additional, An, Xingyue, additional, Bandey, Irfan N, additional, Liadi, Ivan, additional, Cooper, Laurence J.N., additional, Singh, Harjeet, additional, Bot, Adrian, additional, Neelapu, Sattva, additional, and Varadarajan, Navin, additional

Published
2022
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18. 187 Multi-omic single-cell profiling demonstrates that competition for fatty acids and fatty acid oxidation enables tumor-infiltrating lymphocyte function and survival

Author

Paniagua, Melisa Angela, primary, Haymaker, Cara, additional, Adolacion, Jay R, additional, An, Xingyue, additional, Creasy, Caitlin, additional, Fathi, Mohsen, additional, Rezvan, Ali, additional, Geiger, Tamar, additional, Harel, Michal, additional, Robinson, Jonathan, additional, Amritkar, Amit, additional, Woodman, Scott, additional, Hwu, Patrick, additional, Bernatchez, Chantale, additional, and Varadarajan, Navin, additional

Published
2021
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19. Graphene Functionalized Decellularized Scaffold Promotes Skin Cell Proliferation

Author

Jafarkhani, Mahboubeh, Salehi, Zeinab, Bagheri, Zahra, Aayanifard, Zahra, Rezvan, Ali, Doosthosseini, Hamid, Shokrgozar, Mohammad Ali, Jafarkhani, Mahboubeh, Salehi, Zeinab, Bagheri, Zahra, Aayanifard, Zahra, Rezvan, Ali, Doosthosseini, Hamid, and Shokrgozar, Mohammad Ali

Abstract

An increasing number of new strategies for skin tissue engineering have been developed with the potential to mimic the biological properties of native tissue with a high degree of complexity, flexibility, and reproducibility. In this study, decellularized tissue (DT) was prepared from the bovine heart by using chemical treatments. However, the mechanical properties of the DT constructs were poorer than the extra cellular matrix of the skin tissue. To overcome this challenge, hybrid scaffolds of DT and graphene oxide (GO) were developed and the effects of the GO concentration on the morphology, pore size, porosity, mechanical strength, and water uptake capacity of the samples were evaluated. Moreover, the biocompatibility of hybrid scaffolds was studied by Live/Dead staining. The results show that a hybrid scaffold incorporating 3 % graphene oxide improved the mechanical strength and cell viability by ~25 % in comparison to the DT scaffolds. Cell viability results confirmed that the porous scaffolds could support cell adhesion, proliferation, and cell activity for 7 days. This study provides new insight into and opportunities for using graphene‐based materials to develop biomimetic constructs for clinical applications.

Published
2020

21. CIS checkpoint deletion enhances the fitness of cord blood derived natural killer cells transduced with a chimeric antigen receptor

Author

Daher, May, primary, Basar, Rafet, additional, Gokdemir, Elif, additional, Baran, Natalia, additional, Uprety, Nadima, additional, Nunez Cortes, Ana Karen, additional, Mendt, Mayela, additional, Kerbauy, Lucila Nassif, additional, Banerjee, Pinaki P., additional, Sanabria, Mayra Hernandez, additional, Imahashi, Nobuhiko, additional, Li, Li, additional, Wei Inng Lim, Francesca Lorraine, additional, Fathi, Mohsen, additional, Rezvan, Ali, additional, Mohanty, Vakul, additional, Shen, Yifei, additional, Shaim, Hila, additional, Lu, Junjun, additional, Ozcan, Gonca, additional, Ensley, Emily, additional, Kaplan, Mecit, additional, Nandivada, Vandana, additional, Bdaiwi, Mustafa, additional, Acharya, Sunil, additional, Xi, Yuanxin, additional, Wan, Xinhai, additional, Mak, Duncan, additional, Liu, Enli, additional, Ang, Sonny, additional, Muniz-Feliciano, Luis, additional, Li, Ye, additional, Wang, Jing, additional, Kordasti, Shahram, additional, Petrov, Nedyalko, additional, Varadarajan, Navin, additional, Marin, David, additional, Brunetti, Lorenzo, additional, Skinner, Richard J., additional, Lyu, Shangrong, additional, Silva, Leiser, additional, Turk, Rolf, additional, Schubert, Mollie S., additional, Rettig, Garrett R., additional, McNeill, Matthew S., additional, Kurgan, Gavin, additional, Behlke, Mark A., additional, Li, Heng, additional, Fowlkes, Natalie W., additional, Chen, Ken, additional, Konopleva, Marina, additional, Champlin, Richard, additional, Shpall, Elizabeth J., additional, and Rezvani, Katayoun, additional

Published
2020
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24. Generation and Screening of Various CD70 CAR NK Cells Identify the Most Effective Construct Against Hematologic Malignancies

Author

Acharya, Sunil, Basar, Rafet, Daher, May, Li, Ping, Rafei, Hind, Uprety, Nadima, Ensley, Emily, Shanley, Mayra, Kumar, Bijender, Banerjee, Pinaki, Melo Garcia, Luciana, Lin, Paul, Mohanty, Vakul, Pan, Yuchen, Miao, Qi, Kim, Kun Hee, Jiang, Xianli, Li, Ye, Liu, Bin, Nunez Cortes, Ana K., Zhang, Patrick, Fathi, Mohsen, Rezvan, Ali, Montalvo, Melisa J, Liu, Enli, Varadarajan, Navin, Chen, Ken, Marin, David, Champlin, Richard E., Shpall, Elizabeth J., and Rezvani, Katayoun

Abstract

The ability to re-direct the intrinsic power of the immune system against cancer has resulted in unprecedented outcomes in certain patients with otherwise incurable diseases. Natural killer (NK) cells, similar to T cells, are powerful immune effectors that possess intrinsic anti-tumor properties and are capable of generating a strong cytotoxic response upon engaging tumor cells. However, unlike T cells, NK cells do not identify specific antigens and do so in a way that is HLA-independent, posing minimal risk of GvHD. Thus, NK cells have are being explored as a possible allogeneic source for over-the-counter cellular immunotherapy. CD70, the ligand for the CD27 receptor, is an attractive “pan-cancer antigen”, since in addition to being expressed in hematologic malignancies such as acute myeloid leukemia (AML) and lymphoma, it is also expressed on many solid tumors, including bladder, lung, triple negative breast cancer, renal cell carcinoma, pancreatic cancer, and melanoma. Moreover, CD70 is only transiently found on activated T and B lymphocytes and on dendritic cells. To target CD70-expressing cancers, we designed and tested a number of different chimeric antigen receptors (CAR). Briefly, we used the natural interaction between CD70 and CD27 to make a CAR construct that incorporated the extracellular domain of human CD27, which is the natural receptor for CD70. We generated various second-generation CAR constructs that differed in their transmembrane domains (CD27 vs. CD28) and costimulatory domains. We included co-stimulatory domains that are NK-centric (DAP10 and DAP12), T-cell-centric (CD28), or bi-centric (4-1BB). The CD3ζ chain was used as a signaling endodomain, and all the CAR constructs also included IL-15 to enhance in vivo proliferation and persistence. Cord blood (CB)-derived NK cells were efficiently retrovirally transduced with the different CAR constructs and subjected to an in vitro functional screen against various cancer cells to evaluate the best constructs for in vivo validation (Figure 1). The top constructs from our in vitro screen were further evaluated in multiple in vivo models, including a Raji lymphoma model and a THP-1 AML model. The best CAR construct in terms of superior tumor control and prolongation of survival was selected for GMP manufacturing. Based on these preclinical findings, a Phase I/II clinical study is now being conducted at our center to assess the safety and effectiveness of CD70 CAR NK cells against CD70-expressing hematologic malignancies (NCT05092451).

Published
2023
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25. CD28 costimulation augments CAR signaling in NK cells via the LCK/CD3Z/ZAP70 signaling axis.

Author

Acharya S, Basar R, Daher M, Rafei H, Li P, Uprety N, Ensley E, Shanley M, Kumar B, Banerjee PP, Melo Garcia L, Lin P, Mohanty V, Kim KH, Jiang X, Pan Y, Li Y, Liu B, Nunez Cortes AK, Zhang C, Fathi M, Rezvan A, Montalvo MJ, Cha SL, Reyes-Silva F, Shrestha R, Guo X, Kundu K, Biederstadt A, Muniz-Feliciano L, Deyter GM, Kaplan M, Jiang XR, Liu E, Jain A, Roszik J, Fowlkes NW, Solis Soto LM, Raso MG, Khoury JD, Lin P, Vega F, Varadarajan N, Chen K, Marin D, Shpall EJ, and Rezvani K

Abstract

Multiple factors in the design of a chimeric antigen receptor (CAR) influence CAR T-cell activity, with costimulatory signals being a key component. Yet, the impact of costimulatory domains on the downstream signaling and subsequent functionality of CAR-engineered natural killer (NK) cells remains largely unexplored. Here, we evaluated the impact of various costimulatory domains on CAR-NK cell activity, using a CD70-targeting CAR. We found that CD28, a costimulatory molecule not inherently present in mature NK cells, significantly enhanced the antitumor efficacy and long-term cytotoxicity of CAR-NK cells both in vitro and in multiple xenograft models of hematologic and solid tumors. Mechanistically, we showed that CD28 linked to CD3Z creates a platform that recruits critical kinases, such as LCK and ZAP70, initiating a signaling cascade that enhances CAR-NK cell function. Our study provides insights into how CD28 costimulation enhances CAR-NK cell function and supports its incorporation in NK-based CARs for cancer immunotherapy.

Published
2024
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26. Single-dose intranasal vaccination elicits systemic and mucosal immunity against SARS-CoV-2.

Author

An X, Martinez-Paniagua M, Rezvan A, Fathi M, Singh S, Biswas S, Pourpak M, Yee C, Liu X, and Varadarajan N

Abstract

A safe and durable vaccine is urgently needed to tackle the COVID19 pandemic that has infected >15 million people and caused >620,000 deaths worldwide. As with other respiratory pathogens, the nasal compartment is the first barrier that needs to be breached by the SARS-CoV-2 virus before dissemination to the lung. Despite progress at remarkable speed, current intramuscular vaccines are designed to elicit systemic immunity without conferring mucosal immunity. We report the development of an intranasal subunit vaccine that contains the trimeric or monomeric spike protein and liposomal STING agonist as adjuvant. This vaccine induces systemic neutralizing antibodies, mucosal IgA responses in the lung and nasal compartments, and T-cell responses in the lung of mice. Single-cell RNA-sequencing confirmed the concomitant activation of T and B cell responses in a germinal center-like manner within the nasal-associated lymphoid tissues (NALT), confirming its role as an inductive site that can lead to long-lasting immunity. The ability to elicit immunity in the respiratory tract has can prevent the initial establishment of infection in individuals and prevent disease transmission across humans.

Published
2020
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