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2. Global, regional, and national age-specific progress towards the 2020 milestones of the WHO End TB Strategy: a systematic analysis for the Global Burden of Disease Study 2021

Author

Ledesma, Jorge R, Ma, Jianing, Zhang, Meixin, Basting, Ann V L, Chu, Huong Thi, Vongpradith, Avina, Novotney, Amanda, LeGrand, Kate E, Xu, Yvonne Yiru, Dai, Xiaochen, Nicholson, Sneha Ingle, Stafford, Lauryn K, Carter, Austin, Ross, Jennifer M, Abbastabar, Hedayat, Abdoun, Meriem, Abdulah, Deldar Morad, Aboagye, Richard Gyan, Abolhassani, Hassan, Abrha, Woldu Aberhe, Abubaker Ali, Hiwa, Abu-Gharbieh, Eman, Aburuz, Salahdein, Addo, Isaac Yeboah, Adepoju, Abiola Victor, Adhikari, Kishor, Adnani, Qorinah Estiningtyas Sakilah, Adra, Saryia, Afework, Abel, Aghamiri, Shahin, Agyemang-Duah, Williams, Ahinkorah, Bright Opoku, Ahmad, Danish, Ahmad, Sajjad, Ahmadzade, Amir Mahmoud, Ahmed, Haroon, Ahmed, Mohammed, Ahmed, Ayman, Akinosoglou, Karolina, AL-Ahdal, Tareq Mohammed Ali, Alam, Nazmul, Albashtawy, Mohammed, AlBataineh, Mohammad T, Al-Gheethi, Adel Ali Saeed, Ali, Abid, Ali, Endale Alemayehu, Ali, Liaqat, Ali, Zahid, Ali, Syed Shujait Shujait, Allel, Kasim, Altaf, Awais, Al-Tawfiq, Jaffar A, Alvis-Guzman, Nelson, Alvis-Zakzuk, Nelson J., Amani, Reza, Amusa, Ganiyu Adeniyi, Amzat, Jimoh, Andrews, Jason R, Anil, Abhishek, Anwer, Razique, Aravkin, Aleksandr Y, Areda, Damelash, Artamonov, Anton A, Aruleba, Raphael Taiwo, Asemahagn, Mulusew A, Atre, Sachin R, Aujayeb, Avinash, Azadi, Davood, Azadnajafabad, Sina, Azzam, Ahmed Y, Badar, Muhammad, Badiye, Ashish D, Bagherieh, Sara, Bahadorikhalili, Saeed, Baig, Atif Amin, Banach, Maciej, Banik, Biswajit, Bardhan, Mainak, Barqawi, Hiba Jawdat, Basharat, Zarrin, Baskaran, Pritish, Basu, Saurav, Beiranvand, Maryam, Belete, Melaku Ashagrie, Belew, Makda Abate, Belgaumi, Uzma Iqbal, Beloukas, Apostolos, Bettencourt, Paulo J G, Bhagavathula, Akshaya Srikanth, Bhardwaj, Nikha, Bhardwaj, Pankaj, Bhargava, Ashish, Bhat, Vivek, Bhatti, Jasvinder Singh, Bhatti, Gurjit Kaur, Bikbov, Boris, Bitra, Veera R, Bjegovic-Mikanovic, Vesna, Buonsenso, Danilo, Burkart, Katrin, Bustanji, Yasser, Butt, Zahid A, Camargos, Paulo, Cao, Yu, Carr, Sinclair, Carvalho, Felix, Cegolon, Luca, Cenderadewi, Muthia, Cevik, Muge, Chahine, Yaacoub, Chattu, Vijay Kumar, Ching, Patrick R, Chopra, Hitesh, Chung, Eunice, Claassens, Mareli M, Coberly, Kaleb, Cruz-Martins, Natália, Dabo, Bashir, Dadana, Sriharsha, Dadras, Omid, Darban, Isaac, Darega Gela, Jiregna, Darwesh, Aso Mohammad, Dashti, Mahmood, Demessa, Berecha Hundessa, Demisse, Biniyam, Demissie, Solomon, Derese, Awoke Masrie Asrat, Deribe, Kebede, Desai, Hardik Dineshbhai, Devanbu, Vinoth Gnana Chellaiyan, Dhali, Arkadeep, Dhama, Kuldeep, Dhingra, Sameer, Do, Thao Huynh Phuong, Dongarwar, Deepa, Dsouza, Haneil Larson, Dube, John, Dziedzic, Arkadiusz Marian, Ed-Dra, Abdelaziz, Efendi, Ferry, Effendi, Diyan Ermawan, Eftekharimehrabad, Aziz, Ekadinata, Nopryan, Ekundayo, Temitope Cyrus, Elhadi, Muhammed, Elilo, Legesse Tesfaye, Emeto, Theophilus I, Engelbert Bain, Luchuo, Fagbamigbe, Adeniyi Francis, Fahim, Ayesha, Feizkhah, Alireza, Fetensa, Getahun, Fischer, Florian, Gaipov, Abduzhappar, Gandhi, Aravind P, Gautam, Rupesh K, Gebregergis, Miglas W, Gebrehiwot, Mesfin, Gebrekidan, Kahsu Gebrekirstos, Ghaffari, Kazem, Ghassemi, Fariba, Ghazy, Ramy Mohamed, Goodridge, Amador, Goyal, Anmol, Guan, Shi-Yang, Gudeta, Mesay Dechasa, Guled, Rashid Abdi, Gultom, Novianti Br, Gupta, Veer Bala, Gupta, Vivek Kumar, Gupta, Sapna, Hagins, Hailey, Hailu, Semira Goitom, Hailu, Wase Benti, Hamidi, Samer, Hanif, Asif, Harapan, Harapan, Hasan, Rumina Syeda, Hassan, Shoaib, Haubold, Johannes, Hezam, Kamal, Hong, Sung Hwi, Horita, Nobuyuki, Hossain, Md. Belal, Hosseinzadeh, Mehdi, Hostiuc, Mihaela, Hostiuc, Sorin, Huynh, Hong-Han, Ibitoye, Segun Emmanuel, Ikuta, Kevin S, Ilic, Irena M., Ilic, Milena D., Islam, Md. Rabiul, Ismail, Nahlah Elkudssiah, Ismail, Faisal, Jafarzadeh, Abdollah, Jakovljevic, Mihajlo, Jalili, Mahsa, Janodia, Manthan Dilipkumar, Jomehzadeh, Nabi, Jonas, Jost B, Joseph, Nitin, Joshua, Charity Ehimwenma, Kabir, Zubair, Kamble, Bhushan Dattatray, Kanchan, Tanuj, Kandel, Himal, Kanmodi, Kehinde Kazeem, Kantar, Rami S, Karaye, Ibraheem M, Karimi Behnagh, Arman, Kassa, Gebrehiwot G, Kaur, Rimple Jeet, Kaur, Navjot, Khajuria, Himanshu, Khamesipour, Faham, Khan, Yusra H, Khan, M Nuruzzaman, Khan Suheb, Mahammed Ziauddin, Khatab, Khaled, Khatami, Fatemeh, Kim, Min Seo, Kosen, Soewarta, Koul, Parvaiz A, Koulmane Laxminarayana, Sindhura Lakshmi, Krishan, Kewal, Kucuk Bicer, Burcu, Kuddus, Md Abdul, Kulimbet, Mukhtar, Kumar, Nithin, Lal, Dharmesh Kumar, Landires, Iván, Latief, Kamaluddin, Le, Trang Diep Thanh, Le, Thao Thi Thu, Ledda, Caterina, Lee, Munjae, Lee, Seung Won, Lerango, Temesgen L, Lim, Stephen S, Liu, Chaojie, Liu, Xuefeng, Lopukhov, Platon D, Luo, Hong, Lv, Hengliang, Mahajan, Preetam Bhalchandra, Mahboobipour, Amir Ali, Majeed, Azeem, Malakan Rad, Elaheh, Malhotra, Kashish, Malik, Muhammad Sajeel Ahmed, Malinga, Lesibana Anthony, Mallhi, Tauqeer Hussain, Manilal, Aseer, Martinez-Guerra, Bernardo Alfonso, Martins-Melo, Francisco Rogerlândio, Marzo, Roy Rillera, Masoumi-Asl, Hossein, Mathur, Vasundhara, Maude, Richard James, Mehrotra, Ravi, Memish, Ziad A, Mendoza, Walter, Menezes, Ritesh G, Merza, Muayad Aghali, Mestrovic, Tomislav, Mhlanga, Laurette, Misra, Sanjeev, Misra, Arup Kumar, Mithra, Prasanna, Moazen, Babak, Mohammed, Hussen, Mokdad, Ali H, Monasta, Lorenzo, Moore, Catrin E, Mousavi, Parsa, Mulita, Francesk, Musaigwa, Fungai, Muthusamy, Raman, Nagarajan, Ahamarshan Jayaraman, Naghavi, Pirouz, Naik, Ganesh R, Naik, Gurudatta, Nair, Sanjeev, Nair, Tapas Sadasivan, Natto, Zuhair S, Nayak, Biswa Prakash, Negash, Hadush, Nguyen, Dang H, Nguyen, Van Thanh, Niazi, Robina Khan, Nnaji, Chukwudi A, Nnyanzi, Lawrence Achilles, Noman, Efaq Ali, Nomura, Shuhei, Oancea, Bogdan, Obamiro, Kehinde O, Odetokun, Ismail A, Odo, Daniel Bogale Odo, Odukoya, Oluwakemi Ololade, Oh, In-Hwan, Okereke, Chukwuma O, Okonji, Osaretin Christabel, Oren, Eyal, Ortiz-Brizuela, Edgar, Osuagwu, Uchechukwu Levi, Ouyahia, Amel, P A, Mahesh Padukudru, Parija, Pragyan Paramita, Parikh, Romil R, Park, Seoyeon, Parthasarathi, Ashwaghosha, Patil, Shankargouda, Pawar, Shrikant, Peng, Minjin, Pepito, Veincent Christian Filipino, Peprah, Prince, Perdigão, João, Perico, Norberto, Pham, Hoang Tran, Postma, Maarten J, Prabhu, Attur Ravindra Attur, Prasad, Manya, Prashant, Akila, Prates, Elton Junio Sady, Rahim, Fakher, Rahman, Mosiur, Rahman, Muhammad Aziz, Rahmati, Masoud, Rajaa, Sathish, Ramasamy, Shakthi Kumaran, Rao, Indu Ramachandra, Rao, Sowmya J, Rapaka, Deepthi, Rashid, Ahmed Mustafa, Ratan, Zubair Ahmed, Ravikumar, Nakul, Rawaf, Salman, Reddy, Murali Mohan Rama Krishna, Redwan, Elrashdy Moustafa Mohamed, Remuzzi, Giuseppe, Reyes, Luis Felipe, Rezaei, Nazila, Rezaeian, Mohsen, Rezahosseini, Omid, Rodrigues, Mónica, Roy, Priyanka, Ruela, Guilherme de Andrade, Sabour, Siamak, Saddik, Basema, Saeed, Umar, Safi, Sher Zaman, Saheb Sharif-Askari, Narjes, Saheb Sharif-Askari, Fatemeh, Sahebkar, Amirhossein, Sahiledengle, Biniyam, Sahoo, Soumya Swaroop, Salam, Nasir, Salami, Afeez Abolarinwa, Saleem, Samreen, Saleh, Mohamed A, Samadi Kafil, Hossein, Samadzadeh, Sara, Samodra, Yoseph Leonardo, Sanjeev, Rama Krishna, Saravanan, Aswini, Sawyer, Susan M, Selvaraj, Siddharthan, Senapati, Sabyasachi, Senthilkumaran, Subramanian, Shah, Pritik A, Shahid, Samiah, Shaikh, Masood Ali, Sham, Sunder, Shamshirgaran, Mohammad Ali, Shanawaz, Mohd, Sharath, Medha, Sherchan, Samendra P, Shetty, Ranjitha S, Shirzad-Aski, Hesamaddin, Shittu, Aminu, Siddig, Emmanuel Edwar, Silva, João Pedro, Singh, Surjit, Singh, Paramdeep, Singh, Harpreet, Singh, Jasvinder A, Siraj, Md Shahjahan, Siswanto, Siswanto, Solanki, Ranjan, Solomon, Yonatan, Soriano, Joan B, Sreeramareddy, Chandrashekhar T, Srivastava, Vijay Kumar, Steiropoulos, Paschalis, Swain, Chandan Kumar, Tabuchi, Takahiro, Tampa, Mircea, Tamuzi, Jacques JL Lukenze, Tat, Nathan Y, Tavakoli Oliaee, Razieh, Teklay, Gebrehiwot, Tesfaye, Edosa Geta, Tessema, Belay, Thangaraju, Pugazhenthan, Thapar, Rekha, Thum, Chern Choong Chern, Ticoalu, Jansje Henny Vera, Tleyjeh, Imad M, Tobe-Gai, Ruoyan, Toma, Temesgen Mohammed, Tram, Khai Hoan, Udoakang, Aniefiok John, Umar, Tungki Pratama, Umeokonkwo, Chukwuma David, Vahabi, Seyed Mohammad, Vaithinathan, Asokan Govindaraj, van Boven, Job F M, Varthya, Shoban Babu, Wang, Ziyue, Warsame, Muktar S A, Westerman, Ronny, Wonde, Tewodros Eshete, Yaghoubi, Sajad, Yi, Siyan, Yiğit, Vahit, Yon, Dong Keon, Yonemoto, Naohiro, Yu, Chuanhua, Zakham, Fathiah, Zangiabadian, Moein, Zeukeng, Francis, Zhang, Haijun, Zhao, Yang, Zheng, Peng, Zielińska, Magdalena, Salomon, Joshua A, Reiner Jr, Robert C, Naghavi, Mohsen, Vos, Theo, Hay, Simon I, Murray, Christopher J L, and Kyu, Hmwe Hmwe

Published
2024
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7. Clinical Manifestations and Outcomes in Adults Hospitalized With Respiratory Syncytial Virus and Influenza a/B: A Multicenter Observational Cohort Study.

Author

Clausen, Clara Lundetoft, Egeskov-Cavling, Amanda Marie, Hayder, Noor, Sejdic, Adin, Roed, Casper, Holler, Jon Gitz, Nielsen, Lene, Eiberg, Mads Frederik, Rezahosseini, Omid, Østergaard, Christian, Harboe, Zitta Barrella, Fischer, Thea K, Benfield, Thomas, and Lindegaard, Birgitte

Subjects
RESPIRATORY syncytial virus infections, MORTALITY risk factors, RESPIRATORY syncytial virus, LOGISTIC regression analysis, DISEASE risk factors
Abstract

Background Respiratory syncytial virus (RSV) and influenza cause significant health challenges, particularly for individuals with comorbid conditions and older adults. However, information on the clinical manifestations and outcomes of adults hospitalized with RSV in Europe remains limited. Methods This multicenter observational cohort study of adults hospitalized with RSV or influenza A or B from March 2016 to April 2020 investigated the clinical manifestations, mortality risk factors, and association with 90-day mortality rates by logistic regression analysis after adjustment for covariates. Results Of 988 patients hospitalized with either virus, 353 had RSV, 347 had influenza A, and 288 had influenza B infection. Patients with RSV, compared with those with influenza A or B, were more likely to have comorbid conditions (83% for RSV vs 72% for influenza A [ P =.03] and 74% for influenza B [ P =.001]) or pneumonia (41% vs 29% [ P =.03] and 24% [ P <.001], respectively). After adjustment for covariates, RSV infection was associated with an increased all-cause mortality rate within 90 days compared with influenza B (odds ratio, 2.16 [95% confidence interval, 1.20–3.87]; P =.01) but not influenza A (1.38 [.84–2.29]; P =.21). Increasing age and present pneumonia were identified as independent mortality risk factors in patients with RSV. Conclusions Older adults hospitalized with RSV infections are at a higher risk of dying within 90 days of hospitalization than patients admitted with influenza B but at a similar risk as those admitted with influenza A, emphasizing the detrimental effects and severity of older patients being infected with RSV. Our findings underscore the need for strategic testing and vaccination approaches to mitigate the impact of RSV among older adults. [ABSTRACT FROM AUTHOR]

Published
2024
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8. Global, regional, and national sex differences in the global burden of tuberculosis by HIV status, 1990–2019: results from the Global Burden of Disease Study 2019

Author

Ledesma, Jorge R, Ma, Jianing, Vongpradith, Avina, Maddison, Emilie R, Novotney, Amanda, Biehl, Molly H, LeGrand, Kate E, Ross, Jennifer M, Jahagirdar, Deepa, Bryazka, Dana, Feldman, Rachel, Abolhassani, Hassan, Abosetugn, Akine Eshete, Abu-Gharbieh, Eman, Adebayo, Oladimeji M, Adnani, Qorinah Estiningtyas Sakilah, Afzal, Saira, Ahinkorah, Bright Opoku, Ahmad, Sajjad Ahmad, Ahmadi, Sepideh, Ahmed Rashid, Tarik, Ahmed Salih, Yusra, Aklilu, Addis, Akunna, Chisom Joyqueenet, Al Hamad, Hanadi, Alahdab, Fares, Alemayehu, Yosef, Alene, Kefyalew Addis, Ali, Beriwan Abdulqadir, Ali, Liaqat, Alipour, Vahid, Alizade, Hesam, Al-Raddadi, Rajaa M, Alvis-Guzman, Nelson, Amini, Saeed, Amit, Arianna Maever L, Anderson, Jason A, Androudi, Sofia, Antonio, Carl Abelardo T, Antony, Catherine M, Anwer, Razique, Arabloo, Jalal, Arja, Asrat, Asemahagn, Mulusew A, Atre, Sachin R, Azhar, Gulrez Shah, B, Darshan B, Babar, Zaheer-Ud-Din, Baig, Atif Amin, Banach, Maciej, Barqawi, Hiba Jawdat, Barra, Fabio, Barrow, Amadou, Basu, Sanjay, Belgaumi, Uzma Iqbal, Bhagavathula, Akshaya Srikanth, Bhardwaj, Nikha, Bhardwaj, Pankaj, Bhattacharjee, Natalia V, Bhattacharyya, Krittika, Bijani, Ali, Bikbov, Boris, Boloor, Archith, Briko, Nikolay Ivanovich, Buonsenso, Danilo, Burugina Nagaraja, Sharath, Butt, Zahid A, Carter, Austin, Carvalho, Felix, Charan, Jaykaran, Chatterjee, Souranshu, Chattu, Soosanna Kumary, Chattu, Vijay Kumar, Christopher, Devasahayam J, Chu, Dinh-Toi, Claassens, Mareli M, Dadras, Omid, Dagnew, Amare Belachew, Dai, Xiaochen, Dandona, Lalit, Dandona, Rakhi, Daneshpajouhnejad, Parnaz, Darwesh, Aso Mohammad, Dhamnetiya, Deepak, Dianatinasab, Mostafa, Diaz, Daniel, Doan, Linh Phuong, Eftekharzadeh, Sahar, Elhadi, Muhammed, Emami, Amir, Enany, Shymaa, Faraon, Emerito Jose A, Farzadfar, Farshad, Fernandes, Eduarda, Ferro Desideri, Lorenzo, Filip, Irina, Fischer, Florian, Foroutan, Masoud, Frank, Tahvi D, Garcia-Basteiro, Alberto L, Garcia-Calavaro, Christian, Garg, Tushar, Geberemariyam, Biniyam Sahiledengle, Ghadiri, Keyghobad, Ghashghaee, Ahmad, Golechha, Mahaveer, Goodridge, Amador, Gupta, Bhawna, Gupta, Sapna, Gupta, Veer Bala, Gupta, Vivek Kumar, Haider, Mohammad Rifat, Hamidi, Samer, Hanif, Asif, Haque, Shafiul, Harapan, Harapan, Hargono, Arief, Hasaballah, Ahmed I, Hashi, Abdiwahab, Hassan, Shoaib, Hassankhani, Hadi, Hayat, Khezar, Hezam, Kamal, Holla, Ramesh, Hosseinzadeh, Mehdi, Hostiuc, Mihaela, Househ, Mowafa, Hussain, Rabia, Ibitoye, Segun Emmanuel, Ilic, Irena M, Ilic, Milena D, Irvani, Seyed Sina Naghibi, Ismail, Nahlah Elkudssiah, Itumalla, Ramaiah, Jaafari, Jalil, Jacobsen, Kathryn H, Jain, Vardhmaan, Javanmardi, Fatemeh, Jayapal, Sathish Kumar, Jayaram, Shubha, Jha, Ravi Prakash, Jonas, Jost B, Joseph, Nitin, Joukar, Farahnaz, Kabir, Zubair, Kamath, Ashwin, Kanchan, Tanuj, Kandel, Himal, Katoto, Patrick DMC, Kayode, Gbenga A, Kendrick, Parkes J, Kerbo, Amene Abebe, Khajuria, Himanshu, Khalilov, Rovshan, Khatab, Khaled, Khoja, Abdullah T, Khubchandani, Jagdish, Kim, Min Seo, Kim, Yun Jin, Kisa, Adnan, Kisa, Sezer, Kosen, Soewarta, Koul, Parvaiz A, Koulmane Laxminarayana, Sindhura Lakshmi, Koyanagi, Ai, Krishan, Kewal, Kucuk Bicer, Burcu, Kumar, Avinash, Kumar, G Anil, Kumar, Narinder, Kumar, Nithin, Kwarteng, Alexander, Lak, Hassan Mehmood, Lal, Dharmesh Kumar, Landires, Iván, Lasrado, Savita, Lee, Shaun Wen Huey, Lee, Wei-Chen, Lin, Christine, Liu, Xuefeng, Lopukhov, Platon D, Lozano, Rafael, Machado, Daiane Borges, Madhava Kunjathur, Shilpashree, Madi, Deepak, Mahajan, Preetam Bhalchandra, Majeed, Azeem, Malik, Ahmad Azam, Martins-Melo, Francisco Rogerlândio, Mehta, Saurabh, Memish, Ziad A, Mendoza, Walter, Menezes, Ritesh G, Merie, Hayimro Edemealem, Mersha, Amanual Getnet, Mesregah, Mohamed Kamal, Mestrovic, Tomislav, Mheidly, Nour Mheidly, Misra, Sanjeev, Mithra, Prasanna, Moghadaszadeh, Masoud, Mohammadi, Mokhtar, Mohammadian-Hafshejani, Abdollah, Mohammed, Shafiu, Molokhia, Mariam, Moni, Mohammad Ali, Montasir, Ahmed Al, Moore, Catrin E, Nagarajan, Ahamarshan Jayaraman, Nair, Sanjeev, Nair, Suma, Naqvi, Atta Abbas, Narasimha Swamy, Sreenivas, Nayak, Biswa Prakash, Nazari, Javad, Neupane Kandel, Sandhya, Nguyen, Trang Huyen, Nixon, Molly R, Nnaji, Chukwudi A, Ntsekhe, Mpiko, Nuñez-Samudio, Virginia, Oancea, Bogdan, Odukoya, Oluwakemi Ololade, Olagunju, Andrew T, Oren, Eyal, P A, Mahesh, Parthasarathi, Ramakrishnan, Pashazadeh Kan, Fatemeh, Pattanshetty, Sanjay M, Paudel, Rajan, Paul, Pintu, Pawar, Shrikant, Pepito, Veincent Christian Filipino, Perico, Norberto, Pirestani, Majid, Polibin, Roman V, Postma, Maarten J, Pourshams, Akram, Prashant, Akila, Pribadi, Dimas Ria Angga, Radfar, Amir, Rafiei, Alireza, Rahim, Fakher, Rahimi-Movaghar, Vafa, Rahman, Mahfuzar, Rahman, Mosiur, Rahmani, Amir Masoud, Ranasinghe, Priyanga, Rao, Chythra R, Rawaf, David Laith, Rawaf, Salman, Reitsma, Marissa B, Remuzzi, Giuseppe, Renzaho, Andre M N, Reta, Melese Abate, Rezaei, Nima, Rezahosseini, Omid, Rezai, Mohammad sadegh, Rezapour, Aziz, Roshandel, Gholamreza, Roshchin, Denis O, Sabour, Siamak, Saif-Ur-Rahman, KM, Salam, Nasir, Samadi Kafil, Hossein, Samaei, Mehrnoosh, Samy, Abdallah M, Saroshe, Satish, Sartorius, Benn, Sathian, Brijesh, Sawyer, Susan M, Senthilkumaran, Subramanian, Seylani, Allen, Shafaat, Omid, Shaikh, Masood Ali, Sharafi, Kiomars, Shetty, Ranjitha S, Shigematsu, Mika, Shin, Jae Il, Silva, João Pedro, Singh, Jitendra Kumar, Sinha, Smriti, Skryabin, Valentin Yurievich, Skryabina, Anna Aleksandrovna, Spurlock, Emma Elizabeth, Sreeramareddy, Chandrashekhar T, Steiropoulos, Paschalis, Sufiyan, Mu'awiyyah Babale, Tabuchi, Takahiro, Tadesse, Eyayou Girma, Tamir, Zemenu, Tarkang, Elvis Enowbeyang, Tekalegn, Yohannes, Tesfay, Fisaha Haile, Tessema, Belay, Thapar, Rekha, Tleyjeh, Imad I, Tobe-Gai, Ruoyan, Tran, Bach Xuan, Tsegaye, Berhan, Tsegaye, Gebiyaw Wudie, Ullah, Anayat, Umeokonkwo, Chukwuma David, Valadan Tahbaz, Sahel, Vo, Bay, Vu, Giang Thu, Waheed, Yasir, Walters, Magdalene K, Whisnant, Joanna L, Woldekidan, Mesfin Agachew, Wubishet, Befikadu Legesse, Yahyazadeh Jabbari, Seyed Hossein, Yazie, Taklo Simeneh Yazie, Yeshaw, Yigizie, Yi, Siyan, Yiğit, Vahit, Yonemoto, Naohiro, Yu, Chuanhua, Yunusa, Ismaeel, Zastrozhin, Mikhail Sergeevich, Zastrozhina, Anasthasia, Zhang, Zhi-Jiang, Zumla, Alimuddin, Mokdad, Ali H, Salomon, Joshua A, Reiner Jr, Robert C, Lim, Stephen S, Naghavi, Mohsen, Vos, Theo, Hay, Simon I, Murray, Christopher J L, and Kyu, Hmwe Hmwe

Published
2022
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10. Global, regional, and national sex-specific burden and control of the HIV epidemic, 1990–2019, for 204 countries and territories: the Global Burden of Diseases Study 2019

Author

Jahagirdar, Deepa, Walters, Magdalene K, Novotney, Amanda, Brewer, Edmond D, Frank, Tahvi D, Carter, Austin, Biehl, Molly H, Abbastabar, Hedayat, Abhilash, E S, Abu-Gharbieh, Eman, Abu-Raddad, Laith Jamal, Adekanmbi, Victor, Adeyinka, Daniel Adedayo, Adnani, Qorinah Estiningtyas Sakilah, Afzal, Saira, Aghababaei, Soodabeh, Ahinkorah, Bright Opoku, Ahmad, Sajjad, Ahmadi, Keivan, Ahmadi, Sepideh, Ahmadpour, Ehsan, Ahmed, Muktar Beshir, Ahmed Rashid, Tarik, Ahmed Salih, Yusra, Aklilu, Addis, Akram, Tayyaba, Akunna, Chisom Joyqueenet, Al Hamad, Hanadi, Alahdab, Fares, Alanezi, Fahad Mashhour, Aleksandrova, Ekaterina A, Alene, Kefyalew Addis, Ali, Liaqat, Alipour, Vahid, Almustanyir, Sami, Alvis-Guzman, Nelson, Ameyaw, Edward Kwabena, Amu, Hubert, Andrei, Catalina Liliana, Andrei, Tudorel, Anvari, Davood, Arabloo, Jalal, Aremu, Olatunde, Arulappan, Judie, Atnafu, Desta Debalkie, Ayala Quintanilla, Beatriz Paulina, Ayza, Muluken Altaye, Azari, Samad, B, Darshan B, Banach, Maciej, Bärnighausen, Till Winfried, Barra, Fabio, Barrow, Amadou, Basu, Sanjay, Bazargan-Hejazi, Shahrzad, Belay, Habtamu Gebrehana, Berheto, Tezera Moshago, Bezabhe, Woldesellassie Mequanint, Bezabih, Yihienew Mequanint, Bhagavathula, Akshaya Srikanth, Bhardwaj, Nikha, Bhardwaj, Pankaj, Bhattacharyya, Krittika, Bibi, Sadia, Bijani, Ali, Bisignano, Catherine, Bolarinwa, Obasanjo Afolabi, Boloor, Archith, Boltaev, Azizbek A, Briko, Nikolay Ivanovich, Buonsenso, Danilo, Burkart, Katrin, Butt, Zahid A, Cao, Chao, Charan, Jaykaran, Chatterjee, Souranshu, Chattu, Soosanna Kumary, Chattu, Vijay Kumar, Choudhari, Sonali Gajanan, Chu, Dinh-Toi, Couto, Rosa A S, Cowden, Richard G, Dachew, Berihun Assefa, Dadras, Omid, Dagnew, Amare Belachew, Dahlawi, Saad M A, Dai, Xiaochen, Dandona, Lalit, Dandona, Rakhi, das Neves, José, Degenhardt, Louisa, Demeke, Feleke Mekonnen, Desta, Abebaw Alemayehu, Deuba, Keshab, Dhamnetiya, Deepak, Dhungana, Govinda Prasad, Dianatinasab, Mostafa, Diaz, Daniel, Djalalinia, Shirin, Doan, Linh Phuong, Dorostkar, Fariba, Edinur, Hisham Atan, Effiong, Andem, Eftekharzadeh, Sahar, El Sayed Zaki, Maysaa, Elayedath, Rajesh, Elhadi, Muhammed, El-Jaafary, Shaimaa I, El-Khatib, Ziad, Elsharkawy, Aisha, Endalamaw, Aklilu, Endries, Aman Yesuf, Eskandarieh, Sharareh, Ezeonwumelu, Ifeanyi Jude, Ezzikouri, Sayeh, Farahmand, Mohammad, Faraon, Emerito Jose A, Fasanmi, Abidemi Omolara, Ferrero, Simone, Ferro Desideri, Lorenzo, Filip, Irina, Fischer, Florian, Folayan, Morenike Oluwatoyin, Foroutan, Masoud, Fukumoto, Takeshi, Gad, Mohamed M, Gadanya, Muktar A, Gaidhane, Abhay Motiramji, Garg, Tushar, Gayesa, Reta Tsegaye, Gebreyohannes, Eyob Alemayehu, Gesesew, Hailay Abrha, Getachew Obsa, Abera, Ghadiri, Keyghobad, Ghashghaee, Ahmad, Gilani, Syed Amir, Ginindza, Themba G, Glavan, Ionela-Roxana, Glushkova, Ekaterina Vladimirovna, Golechha, Mahaveer, Gugnani, Harish Chander, Gupta, Bhawna, Gupta, Sapna, Gupta, Veer Bala, Gupta, Vivek Kumar, Hamidi, Samer, Handanagic, Senad, Haque, Shafiul, Harapan, Harapan, Hargono, Arief, Hasaballah, Ahmed I, Hashi, Abdiwahab, Hassan, Shoaib, Hassanipour, Soheil, Hayat, Khezar, Heredia-Pi, Ileana, Hezam, Kamal, Holla, Ramesh, Hoogar, Praveen, Hoque, Mohammad Enamul, Hosseini, Mostafa, Hosseinzadeh, Mehdi, Hsairi, Mohamed, Hussain, Rabia, Ibitoye, Segun Emmanuel, Idrisov, Bulat, Ikuta, Kevin S, Ilesanmi, Olayinka Stephen, Ilic, Irena M, Ilic, Milena D, Irvani, Seyed Sina Naghibi, Islam, M Mofizul, Ismail, Nahlah Elkudssiah, Itumalla, Ramaiah, Iyamu, Ihoghosa Osamuyi, Jabbarinejad, Roxana, Jain, Vardhmaan, Jayawardena, Ranil, Jha, Ravi Prakash, Joseph, Nitin, Kabir, Ali, Kabir, Zubair, Kalhor, Rohollah, Kaliyadan, Feroze, Kamath, Ashwin, Kanchan, Tanuj, Kandel, Himal, Kassahun, Getinet, Katoto, Patrick DMC, Kayode, Gbenga A, Kebede, Ermiyas Mulu, Kebede, Hafte Kahsay, Khajuria, Himanshu, Khalid, Nauman, Khan, Ejaz Ahmad, Khan, Gulfaraz, Khatab, Khaled, Kim, Min Seo, Kim, Yun Jin, Kisa, Adnan, Kisa, Sezer, Kochhar, Sonali, Korshunov, Vladimir Andreevich, Koul, Parvaiz A, Koulmane Laxminarayana, Sindhura Lakshmi, Koyanagi, Ai, Krishan, Kewal, Kuate Defo, Barthelemy, Kumar, G Anil, Kumar, Manasi, Kumar, Nithin, Kwarteng, Alexander, Lal, Dharmesh Kumar, Landires, Iván, Lasrado, Savita, Lassi, Zohra S, Lazarus, Jeffrey V, Lee, Jane Jean-Hee, Lee, Yeong Yeh, LeGrand, Kate E, Lin, Christine, Liu, Xuefeng, Maddison, Emilie R, Magdy Abd El Razek, Hassan, Mahasha, Phetole Walter, Majeed, Azeem, Makki, Alaa, Malik, Ahmad Azam, Manamo, Wondimu Ayele, Mansournia, Mohammad Ali, Martins-Melo, Francisco Rogerlândio, Masoumi, Seyedeh Zahra, Memish, Ziad A, Menezes, Ritesh G, Mengesha, Endalkachew Worku, Merie, Hayimro Edemealem, Mersha, Amanual Getnet, Mestrovic, Tomislav, Meylakhs, Peter, Mheidly, Nour, Miller, Ted R, Mirica, Andreea, Moazen, Babak, Mohammad, Yousef, Mohammadi, Mokhtar, Mohammed, Arif, Mohammed, Salahuddin, Mohammed, Shafiu, Moitra, Modhurima, Mokdad, Ali H, Molokhia, Mariam, Moni, Mohammad Ali, Moradi, Ghobad, Moradi, Yousef, Mpundu-Kaambwa, Christine, Mubarik, Sumaira, Munro, Sandra B, Mwanri, Lillian, Nachega, Jean B, Nagarajan, Ahamarshan Jayaraman, Narayana, Aparna Ichalangod, Naveed, Muhammad, Nayak, Biswa Prakash, Nduaguba, Sabina O, Neupane Kandel, Sandhya, Nguefack-Tsague, Georges, Nguyen, Trang Huyen, Nixon, Molly R, Nnaji, Chukwudi A, Noubiap, Jean Jacques, Nuñez-Samudio, Virginia, Nyirenda, Thomas Elliot, Oghenetega, Onome Bright, Olagunju, Andrew T, Olakunde, Babayemi Oluwaseun, Owopetu, Oluwatomi Funbi, P A, Mahesh, Padubidri, Jagadish Rao, Pakhale, Smita, Parekh, Tarang, Pashazadeh Kan, Fatemeh, Pawar, Shrikant, Pepito, Veincent Christian Filipino, Peprah, Emmanuel K, Pinheiro, Marina, Pokhrel, Khem Narayan, Polibin, Roman V, Pollok, Richard Charles G, Postma, Maarten J, Quazi Syed, Zahiruddin, Radfar, Amir, Radhakrishnan, Raghu Anekal, Rahim, Fakher, Rahimi-Movaghar, Vafa, Rahimzadeh, Shadi, Rahman, Mosiur, Rahmani, Amir Masoud, Ram, Pradhum, Ranabhat, Chhabi Lal, Ranasinghe, Priyanga, Rao, Chythra R, Rao, Sowmya J, Rathi, Priya, Rawaf, David Laith, Rawaf, Salman, Regassa, Lemma Demissie, Rehman, Inayat ur, Renzaho, Andre M N, Rezaei, Nima, Rezahosseini, Omid, Rezai, Mohammad sadegh, Rezapour, Aziz, Ripon, Rezaul Karim, Rodrigues, Voilet, Roshchin, Denis O, Rwegerera, Godfrey M, Saeed, Umar, Saeedi Moghaddam, Sahar, Sagar, Rajesh, Saif-Ur-Rahman, KM, Salem, Marwa Rashad, Samaei, Mehrnoosh, Samy, Abdallah M, Santric-Milicevic, Milena M, Saroshe, Satish, Sathian, Brijesh, Satpathy, Maheswar, Sawhney, Monika, Schutte, Aletta Elisabeth, Seylani, Allen, Shaikh, Masood Ali, Shaka, Mohammed Feyisso, Shamshad, Hina, Shamsizadeh, Morteza, Shannawaz, Mohammed, Shetty, Adithi, Shin, Jae Il, Shivakumar, K M, Singh, Jasvinder A, Skryabin, Valentin Yurievich, Skryabina, Anna Aleksandrovna, Somayaji, Ranjani, Soshnikov, Sergey, Spurlock, Emma Elizabeth, Stein, Dan J, Sufiyan, Mu'awiyyah Babale, Tadbiri, Hooman, Tadesse, Birkneh Tilahun, Tadesse, Eyayou Girma, Tamiru, Animut Tagele, Tarkang, Elvis Enowbeyang, Taveira, Nuno, Tekalegn, Yohannes, Tesfay, Fisaha Haile, Tessema, Gizachew Assefa, Thapar, Rekha, Tovani-Palone, Marcos Roberto, Traini, Eugenio, Tran, Bach Xuan, Tsai, Alexander C, Tusa, Biruk Shalmeno, Ullah, Saif, Umeokonkwo, Chukwuma David, Unnikrishnan, Bhaskaran, Valadan Tahbaz, Sahel, Villafañe, Jorge Hugo, Vladimirov, Sergey Konstantinovitch, Vo, Bay, Vongpradith, Avina, Vu, Giang Thu, Waheed, Yasir, Wamai, Richard G, Wang, Guan, Wang, Yanzhong, Ward, Paul, Westerman, Ronny, Winkler, Andrea Sylvia, Yadav, Lalit, Yahyazadeh Jabbari, Seyed Hossein, Yazie, Taklo Simeneh, Yi, Siyan, Yigit, Vahit, Yirdaw, Birhanu Wubale, Yonemoto, Naohiro, Yu, Chuanhua, Yunusa, Ismaeel, Zastrozhin, Mikhail Sergeevich, Zastrozhina, Anasthasia, Zhang, Zhi-Jiang, Zumla, Alimuddin, Salomon, Joshua A, Eaton, Jeffrey W, Naghavi, Mohsen, Dwyer-Lindgren, Laura, Wang, Haidong, Lim, Stephen S, Hay, Simon I, Murray, Christopher J L, and Kyu, Hmwe Hmwe

Published
2021
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11. Should SARS-CoV-2 serological testing be used in the decision to deliver a COVID-19 vaccine booster? A pro-con assessment

Author

Augello, Matteo, Wagenhäuser, Isabell, Krone, Manuel, Dauby, Nicolas, Ferrara, Pietro, Sabbatucci, Michela, Ruta, Simona, Rezahosseini, Omid, Velikov, Petar, Gkrania-Klotsas, Effrossyni, Montes, Jose, Franco-Paredes, Carlos, Goodman, Anna L., Küçükkaya, Sertaç, Tuells, Jose, Harboe, Zitta Barrella, Epaulard, Olivier, Augello, Matteo, Wagenhäuser, Isabell, Krone, Manuel, Dauby, Nicolas, Ferrara, Pietro, Sabbatucci, Michela, Ruta, Simona, Rezahosseini, Omid, Velikov, Petar, Gkrania-Klotsas, Effrossyni, Montes, Jose, Franco-Paredes, Carlos, Goodman, Anna L., Küçükkaya, Sertaç, Tuells, Jose, Harboe, Zitta Barrella, and Epaulard, Olivier

Abstract

info:eu-repo/semantics/published

Published
2024

12. Evidence for Immunity against Tetanus, Diphtheria, and Pertussis through Natural Infection or Vaccination in Adult Solid Organ Transplant Recipients:A Systematic Review

Author

Lenzing, Emil, Harboe, Zitta Barrella, Sørensen, Søren Schwartz, Rasmussen, Allan, Nielsen, Susanne Dam, Rezahosseini, Omid, Lenzing, Emil, Harboe, Zitta Barrella, Sørensen, Søren Schwartz, Rasmussen, Allan, Nielsen, Susanne Dam, and Rezahosseini, Omid

Abstract

(1) Background: We aim to systematically review the current evidence on immunity against tetanus, diphtheria, and pertussis in adult solid organ transplantation (SOT) recipients, either through natural infection or vaccination. (2) Methods: This systematic review was conducted per PRISMA guidelines. We assessed the risk of bias using the Cochrane RoB 2 and ROBINS-I and summarized the findings narratively due to the heterogeneity of the studies. (3) Results: Of the 315 screened articles, 11 were included. Tetanus immunity varied between 55% and 86%, diphtheria immunity from 23% to 75%, and pertussis immunity was between 46% and 82%. Post-vaccination immunity showed variation across the studies, with some indicating reductions and others no change, with antibody responses influenced by transplanted organs, gender, age, and immunosuppressive regimens. The single randomized study exhibited a low risk of bias, while of the ten non-randomized studies, six showed moderate and four serious risks of bias, necessitating cautious interpretation of results. (4) Conclusions: SOT recipients exhibit considerable immunity against tetanus and diphtheria at transplantation, but this immunity decreases over time. Although vaccination can enhance this immunity, the response may be suboptimal, and the increased antibody levels may not persist, underscoring the need for tailored vaccination strategies in this vulnerable population., (1) Background: We aim to systematically review the current evidence on immunity against tetanus, diphtheria, and pertussis in adult solid organ transplantation (SOT) recipients, either through natural infection or vaccination. (2) Methods: This systematic review was conducted per PRISMA guidelines. We assessed the risk of bias using the Cochrane RoB 2 and ROBINS-I and summarized the findings narratively due to the heterogeneity of the studies. (3) Results: Of the 315 screened articles, 11 were included. Tetanus immunity varied between 55% and 86%, diphtheria immunity from 23% to 75%, and pertussis immunity was between 46% and 82%. Post-vaccination immunity showed variation across the studies, with some indicating reductions and others no change, with antibody responses influenced by transplanted organs, gender, age, and immunosuppressive regimens. The single randomized study exhibited a low risk of bias, while of the ten non-randomized studies, six showed moderate and four serious risks of bias, necessitating cautious interpretation of results. (4) Conclusions: SOT recipients exhibit considerable immunity against tetanus and diphtheria at transplantation, but this immunity decreases over time. Although vaccination can enhance this immunity, the response may be suboptimal, and the increased antibody levels may not persist, underscoring the need for tailored vaccination strategies in this vulnerable population.

Published
2024

13. Clonal hematopoiesis and COVID-19 hospitalization in Danish adults

Author

Burgos Sequeros, Celia, Tulstrup, Morten, Bliddal, Sofie, Sørensen, Karina Meden, Nissen, Ioanna, Rezahosseini, Omid, Brooks, Patrick Terrence, Feenstra, Bjarke, Gang, Anne Ortved, Geller, Frank, Hald, Annemette, Harboe, Zitta Barrella, Helleberg, Marie, Jespersen, Jakob S., Lebech, Anne Mette, Lindegaard, Birgitte, Mogensen, Trine H., Møller, Maria Elizabeth Engel, Nielsen, Claus Henrik, Niemann, Carsten Utoft, Podlekareva, Daria, Sejdic, Adin, Sørensen, Erik, Teglgaard, Rebecca Svanberg, Tommerup, Niels, Weis, Nina, Brunak, Søren, Pedersen, Ole Birger Vestager, Banasik, Karina, Feldt-Rasmussen, Ulla, Nielsen, Susanne Dam, Ostrowski, Sisse Rye, Grønbæk, Kirsten, Burgos Sequeros, Celia, Tulstrup, Morten, Bliddal, Sofie, Sørensen, Karina Meden, Nissen, Ioanna, Rezahosseini, Omid, Brooks, Patrick Terrence, Feenstra, Bjarke, Gang, Anne Ortved, Geller, Frank, Hald, Annemette, Harboe, Zitta Barrella, Helleberg, Marie, Jespersen, Jakob S., Lebech, Anne Mette, Lindegaard, Birgitte, Mogensen, Trine H., Møller, Maria Elizabeth Engel, Nielsen, Claus Henrik, Niemann, Carsten Utoft, Podlekareva, Daria, Sejdic, Adin, Sørensen, Erik, Teglgaard, Rebecca Svanberg, Tommerup, Niels, Weis, Nina, Brunak, Søren, Pedersen, Ole Birger Vestager, Banasik, Karina, Feldt-Rasmussen, Ulla, Nielsen, Susanne Dam, Ostrowski, Sisse Rye, and Grønbæk, Kirsten

Published
2024

14. Risk of intensive care unit admission and mortality in patients hospitalized due to influenza A or B and SARS‑CoV‑2 variants Omicron or Delta.

Author

Rezahosseini, Omid, Roed, Casper, Sejdic, Adin, Eiberg, Mads Frederik, Nielsen, Lene, Boel, Jonas, Johannesen, Caroline Klint, van Wijhe, Maarten, Franck, Kristina Træholt, Ostrowski, Sisse Rye, Lindegaard, Birgitte, Fischer, Thea K., Knudsen, Troels Bygum, Holler, Jon Gitz, Harboe, Zitta Barrella, Lindgaard‐Jensen, Betina, Søborg, Christian, Nielsen, Thyge Lynghøj, Bernhard, Peter Haahr, and Pedersen, Emilie Marie Juelstorp

Subjects
*SARS-CoV-2, *SARS-CoV-2 Omicron variant, *SARS-CoV-2 Delta variant, *VIRUS diseases, *INTENSIVE care units
Abstract

Background: Respiratory viral infections have significant global health impacts. We compared 30‐day intensive care unit (ICU) admission and all‐cause mortality risks in patients with severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) Delta and Omicron variants versus influenza A and B (A/B). Methods: Data from two retrospective inpatient cohorts in Copenhagen were analyzed. Cohorts included hospitalized influenza A/B patients (2017–2018) and SARS‐CoV‐2 Delta/Omicron patients (2021–2022), aged ≥18 years, admitted within 14 days of a positive real‐time polymerase chain reaction test result. Cumulative ICU admission and mortality rates were estimated using the Aalen–Johansen estimator. Cox regression models calculated hazard ratios (HRs) for ICU admission and mortality. Results: The study encompassed 1459 inpatients (Delta: 49%; Omicron: 26%; influenza A: 6.4%; and influenza B: 18%). Cumulative incidence of ICU admission was 11%, 4.0%, 7.5%, and 4.1%, for Delta, Omicron, influenza A, and B, respectively. For ICU admission, adjusted HRs (aHRs) were 3.1 (p <.001) and 1.5 (p =.34) for Delta and Omicron versus influenza B, and 1.5 (p =.36) and 0.71 (p =.48) versus influenza A. For mortality, aHRs were 3.8 (p <.001) and 3.4 (p <.001) for Delta and Omicron versus influenza B, and 2.1 (p =.04) and 1.9 (p =.11) versus influenza A. Conclusion: Delta but not Omicron inpatients had an increased risk for ICU admission compared to influenza B; however, both variants were associated with higher risks of mortality than influenza B. Only Delta inpatients had a higher risk of mortality than influenza A inpatients. [ABSTRACT FROM AUTHOR]

Published
2024
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16. Anemia in liver transplant recipients: prevalence, severity, risk factors, and survival

Author

Hegland, Nina Øksnes, primary, Rezahosseini, Omid, additional, Pedersen, Christian Ross, additional, Møller, Dina Leth, additional, Bugge, Terese Brun, additional, Wareham, Neval Ete, additional, Arentoft, Nicoline Stender, additional, Hillingsø, Jens, additional, Lund, Thomas Kromann, additional, Rasmussen, Allan, additional, and Nielsen, Susanne Dam, additional

Published
2023
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18. Anemia in liver transplant recipients: prevalence, severity, risk factors, and survival.

Author

Hegland, Nina Øksnes, Rezahosseini, Omid, Pedersen, Christian Ross, Møller, Dina Leth, Bugge, Terese Brun, Wareham, Neval Ete, Arentoft, Nicoline Stender, Hillingsø, Jens, Lund, Thomas Kromann, Rasmussen, Allan, and Nielsen, Susanne Dam

Subjects
*LIVER transplantation, *ANEMIA, *LIVER failure, *LOGISTIC regression analysis, *AUTOIMMUNE diseases
Abstract

Information about anemia in liver transplant (LTx) recipients is scarce. We investigated the prevalence and severity of anemia before and within the first‐year post‐LTx, risk factors for having anemia before LTx, and 1‐year survival according to anemia status before LTx. This retrospective cohort study received data from The Knowledge Center for Transplantation database at Rigshospitalet, Copenhagen, Denmark. Uni‐ and multivariate logistic regression were used to investigate factors associated with anemia and a Kaplan–Meier plot to illustrate the probability of survival. We included 346 first‐time adult LTx recipients. The median age was 50 years (IQR: 42–57), and 203 (59%) were male. The prevalence of anemia before and 1‐year post‐LTx were 69 and 45%, respectively. Male sex (aOR 4.0 [95% CI: 2.2–7.2]; p < 0.001) and each unit increase in MELD score (aOR 1.2 [95% CI: 1.1–1.2]; p < 0.001) were positively associated with anemia before LTx. Compared to autoimmune liver diseases, LTx recipients with fulminant hepatic failure (aOR 0.03 [0.00–0.17]; p = 0.001) had lower odds for anemia. The 1‐year survival in LTx recipients who had and did not have anemia before transplantation were 93 and 91% (p = 0.47). Anemia was frequent among LTx recipients, and anemia before LTx did not affect 1‐year survival. [ABSTRACT FROM AUTHOR]

Published
2024
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19. Clonal hematopoiesis and COVID‐19 hospitalization in Danish adults.

Author

Sequeros, Celia Burgos, Tulstrup, Morten, Bliddal, Sofie, Sørensen, Karina Meden, Nissen, Ioanna, Rezahosseini, Omid, Brooks, Patrick Terrence, Feenstra, Bjarke, Gang, Anne Ortved, Geller, Frank, Hald, Annemette, Harboe, Zitta Barrella, Helleberg, Marie, Jespersen, Jakob S., Lebech, Anne‐Mette, Lindegaard, Birgitte, Mogensen, Trine H., Møller, Maria Elizabeth Engel, Nielsen, Claus Henrik, and Niemann, Carsten Utoft

Published
2024
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20. Prediction of herpes virus infections after solid organ transplantation: a prospective study of immune function

Author

Møller, Dina Leth, primary, Sørensen, Søren Schwartz, additional, Rezahosseini, Omid, additional, Rasmussen, Daniel Bräuner, additional, Arentoft, Nicoline Stender, additional, Loft, Josefine Amalie, additional, Perch, Michael, additional, Gustafsson, Finn, additional, Lundgren, Jens, additional, Scheike, Thomas, additional, Knudsen, Jenny Dahl, additional, Ostrowski, Sisse Rye, additional, Rasmussen, Allan, additional, and Nielsen, Susanne Dam, additional

Published
2023
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23. Implementation of a vaccination clinic for adult solid organ transplant candidates:A single-center experience

Author

Harboe, Zitta Barrella, Hald, Annemette, Ekenberg, Christina, Ete Wareham, Neval, Fogt Lundbo, Lene, Holler, Jon Gitz, Qvist, Tavs, Rask Hamm, Sebastian, Bjerrum, Stephanie, Rezahosseini, Omid, Suno Krohn, Paul, Gustafsson, Finn, Perch, Michael, Rasmussen, Allan, Dam Nielsen, Susanne, Harboe, Zitta Barrella, Hald, Annemette, Ekenberg, Christina, Ete Wareham, Neval, Fogt Lundbo, Lene, Holler, Jon Gitz, Qvist, Tavs, Rask Hamm, Sebastian, Bjerrum, Stephanie, Rezahosseini, Omid, Suno Krohn, Paul, Gustafsson, Finn, Perch, Michael, Rasmussen, Allan, and Dam Nielsen, Susanne

Abstract

Vaccination is an evidence-based strategy to prevent or reduce the severity of infectious diseases (ID). Here, we aimed to describe the experience of implementing a vaccination clinic specifically targeting liver, heart, lung, and combined dual organ transplantation at a single transplantation center in Denmark. In this cohort of 242 solid organ transplant (SOT) candidates, we investigated seroprotection and the proportion of recommended vaccinations documented before transplantation. Furthermore, we registered completed vaccinations after ID consultations. The median age in our cohort was 53 years (IQR, 42–60), 60% were males (n = 135), and liver transplants (n = 138; 57%) were the most frequently planned organ transplants. Before the consultation to the vaccination clinic, influenza and pneumococcal vaccines had the highest proportion of documented vaccination (58% and 37%, respectively). Serological protection was more frequently observed for measles, mumps, or rubella (MMR, approximately 90% for each), while only 30% (n = 72) of SOT candidates showed seroprotection against pneumococcal disease. All SOT candidates required at least one of the recommended vaccines, and over 90% required three or more. At least 10% of patients in our cohort needed a live attenuated vaccine for either MMR or yellow fever. The most frequently administered vaccine was the tetanus–diphtheria-acelullar pertussis (Tdap) booster (n = 217; 90%), influenza vaccination was either administered (n = 16; 7%) or recommended (n = 226; 93%), PCV13 was administered (n = 155; 64%) or recommended (n = 27; 11%), and PPSV23 was either administered (n = 18; 7.4%) or recommended (n = 140; 58%). All SOT candidates adhered completely to their vaccination schedules. Based on our findings, we recommend prioritizing vaccination before transplantation by providing ID consultations for SOT candidates., Vaccination is an evidence-based strategy to prevent or reduce the severity of infectious diseases (ID). Here, we aimed to describe the experience of implementing a vaccination clinic specifically targeting liver, heart, lung, and combined dual organ transplantation at a single transplantation center in Denmark. In this cohort of 242 solid organ transplant (SOT) candidates, we investigated seroprotection and the proportion of recommended vaccinations documented before transplantation. Furthermore, we registered completed vaccinations after ID consultations. The median age in our cohort was 53 years (IQR, 42–60), 60% were males (n = 135), and liver transplants (n = 138; 57%) were the most frequently planned organ transplants. Before the consultation to the vaccination clinic, influenza and pneumococcal vaccines had the highest proportion of documented vaccination (58% and 37%, respectively). Serological protection was more frequently observed for measles, mumps, or rubella (MMR, approximately 90% for each), while only 30% (n = 72) of SOT candidates showed seroprotection against pneumococcal disease. All SOT candidates required at least one of the recommended vaccines, and over 90% required three or more. At least 10% of patients in our cohort needed a live attenuated vaccine for either MMR or yellow fever. The most frequently administered vaccine was the tetanus–diphtheria-acelullar pertussis (Tdap) booster (n = 217; 90%), influenza vaccination was either administered (n = 16; 7%) or recommended (n = 226; 93%), PCV13 was administered (n = 155; 64%) or recommended (n = 27; 11%), and PPSV23 was either administered (n = 18; 7.4%) or recommended (n = 140; 58%). All SOT candidates adhered completely to their vaccination schedules. Based on our findings, we recommend prioritizing vaccination before transplantation by providing ID consultations for SOT candidates.

Published
2023

27. Humoral and T-cell response 12 months after the first BNT162b2 vaccination in solid organ transplant recipients and controls: Kinetics, associated factors, and role of SARS-CoV-2 infection

Author

Rezahosseini, Omid, primary, Hamm, Sebastian Rask, additional, Heftdal, Line Dam, additional, Pérez-Alós, Laura, additional, Møller, Dina Leth, additional, Perch, Michael, additional, Madsen, Johannes Roth, additional, Hald, Annemette, additional, Hansen, Cecilie Bo, additional, Armenteros, Jose Juan Almagro, additional, Pries-Heje, Mia Marie, additional, Hasselbalch, Rasmus Bo, additional, Fogh, Kamille, additional, Frikke-Schmidt, Ruth, additional, Hilsted, Linda Maria, additional, Sørensen, Erik, additional, Ostrowski, Sisse Rye, additional, Harboe, Zitta Barrella, additional, Iversen, Kasper, additional, Bundgaard, Henning, additional, Sørensen, Søren Schwartz, additional, Rasmussen, Allan, additional, Garred, Peter, additional, and Nielsen, Susanne Dam, additional

Published
2023
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29. Incidence, Risk Factors, and Consequences of Human Alphaherpesvirus Infections in Patients With Psoriasis Who Initiate Methotrexate or Biologic Agents

Author

Rezahosseini, Omid, primary, Liljendahl, Mie Sylow, additional, Loft, Nikolai, additional, Møller, Dina Leth, additional, Harboe, Zitta Barrella, additional, Rasmussen, Mads Kirchheiner, additional, Ajgeiy, Kawa Khaled, additional, Egeberg, Alexander, additional, Skov, Lone, additional, and Nielsen, Susanne Dam, additional

Published
2022
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30. Prediction of herpes virus infections after solid organ transplantation: a prospective study of immune function.

Author

Leth Møller, Dina, Schwartz Sørensen, Søren, Rezahosseini, Omid, Bräuner Rasmussen, Daniel, Stender Arentoft, Nicoline, Loft, Josefine Amalie, Perch, Michael, Gustafsson, Finn, Lundgren, Jens, Scheike, Thomas, Dahl Knudsen, Jenny, Rye Ostrowski, Sisse, Rasmussen, Allan, and Dam Nielsen, Susanne

Subjects
VIRUS diseases, TRANSPLANTATION of organs, tissues, etc., DIAGNOSTIC use of polymerase chain reaction, HERPES simplex virus, LONGITUDINAL method
Abstract

Introduction: Herpes virus infections are a major concern after solid organ transplantation and linked to the immune function of the recipient. We aimed to determine the incidence of positive herpes virus (cytomegalovirus (CMV), Epstein-Barr virus (EBV), herpes simplex virus type 1/2 (HSV-1/2), and varicella zoster virus (VZV)) PCR tests during the first year post-transplantation and assess whether a model including immune function pre-transplantation and three months posttransplantation could predict a subsequent positive herpes virus PCR. Methods: All participants were preemptively screened for CMV, and EBV IgG-negative participants were screened for EBV during the first year posttransplantation. Herpes virus PCR tests for all included herpes viruses (CMV, EBV, HSV-1/2, and VZV) were retrieved from the Danish Microbiology database containing nationwide PCR results from both hospitals and outpatient clinics. Immune function was assessed by whole blood stimulation with A) LPS, B) R848, C) Poly I:C, and D) a blank control. Cytokine concentrations (TNF-α, IL-1β, IL-6, IL-8, IL-10, IL-12p40, IL-17A, IFN-α, and IFN-γ) were measured using Luminex. Results: We included 123 liver (54%), kidney (26%), and lung (20%) transplant recipients. The cumulative incidence of positive herpes virus PCR tests was 36.6% (95% CI: 28.1-45.1) during the first year post-transplantation. The final prediction model included recipient age, type of transplantation, CMV serostatus, and change in Poly I:C-induced IL-12p40 from pre-transplantation to three months post-transplantation. The prediction model had an AUC of 77% (95% CI: 61-92). Risk scores were extracted from the prediction model, and the participants were divided into three risk groups. Participants with a risk score <5 (28% of the cohort), 5-10 (45% of the cohort), and >10 (27% of the cohort) had a cumulative incidence of having a positive herpes virus PCR test at 5.8%, 25%, and 73%, respectively (p < 0.001) Conclusion: In conclusion, the incidence of positive herpes virus PCR tests was high, and a risk model including immune function allowed the prediction of positive herpes virus PCR and may be used to identify recipients at higher risk. [ABSTRACT FROM AUTHOR]

Published
2023
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31. Evidence for immunity via natural infection or vaccination against diphtheria, tetanus, and pertussis in adult solid organ transplant recipients: a systematic review

Author

Rezahosseini, Omid, Lenzing, Emil, Sørensen, Søren, Rasmussen, Allan, and Nielsen, Susanne

Subjects
Transplantation, Vaccination, Medicine and Health Sciences, Immunity, Infection, complex mixtures
Abstract

Diphtheria, tetanus, and pertussis (DTP) are vaccine-preventable bacterial infections. There are reports of tetanus and pertussis in kidney transplant recipients. Vaccination against DTP has been recommended by international guidelines. Although, the recommendations for solid organ transplant (SOT) recipients are based on studies on children. We aim to systematically review evidence about immunity via natural infection or vaccination against diphtheria, tetanus, and pertussis in adult solid organ transplant recipients.

Published
2022
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35. Pneumocystis jirovecii pneumonia in liver transplant recipients in an era of routine prophylaxis

Author

Andreasen, Philip B., Rezahosseini, Omid, Møller, Dina L., Wareham, Neval E., Thomsen, Magda T., Houmami, Ranya, Knudsen, Andreas D., Knudsen, Jenny, Kurtzhals, Jørgen A.L., Rostved, Andreas A., Pedersen, Christian R., Rasmussen, Allan, Nielsen, Susanne D., Andreasen, Philip B., Rezahosseini, Omid, Møller, Dina L., Wareham, Neval E., Thomsen, Magda T., Houmami, Ranya, Knudsen, Andreas D., Knudsen, Jenny, Kurtzhals, Jørgen A.L., Rostved, Andreas A., Pedersen, Christian R., Rasmussen, Allan, and Nielsen, Susanne D.

Abstract

Background: Pneumocystis jirovecii pneumonia (PCP) is an opportunistic infection in organ transplant recipients that may be prevented by antibiotic prophylaxis. We aimed to investigate the incidence rate (IR) of PCP and the related hospitalization and mortality rates in liver transplant recipients in an era of routine prophylaxis. Methods: We included all adult liver transplant recipients transplanted at Rigshospitalet between January 1, 2011 and October 1, 2019. Microbiology data were obtained from the Danish Microbiology Database (MiBa), a national database containing all data from all Departments of Clinical Microbiology in Denmark receiving samples from both hospitals and general practices. According to local guidelines, PCP prophylaxis was initiated 1 week posttransplantation and discontinued after 6 months or sooner in patients experiencing side effects. Results: We included 343 liver transplant recipients with 1153 person-years of follow-up (PYFU), of which 269 (78%) received PCP prophylaxis during the first 6 months posttransplantation. Seven (2%) recipients were diagnosed with PCP during follow-up. In the first 6 months posttransplantation and in 269 transplant recipients who received prophylaxis there were zero PCP events while the IR was 32 (95% confidence interval [CI] 2.9–148) per 1000 PYFU in 74 recipient who did not receive prophylaxis. During 7th to 12th month posttransplantation the IR was 20 (95% CI: 5.5–53) per 1000 PYFU. All seven (100%) recipients diagnosed with PCP were hospitalized, however none died. Conclusions: PCP was not detected in liver transplant recipients while on prophylaxis. Though, it worth mentioning that two out of the seven PCP patients received high-dose prednisolone before the PCP event. All liver transplant recipients with PCP were hospitalized, but none died. Randomized clinical trials to determine the optimal duration of prophylaxis are warranted.

Published
2022

36. Prevalence of emphysema in people living with human immunodeficiency virus in the current combined antiretroviral therapy era:A systematic review

Author

Ringheim, Hedda, Thudium, Rebekka F., Jensen, Jens Ulrik S., Rezahosseini, Omid, Nielsen, Susanne D., Ringheim, Hedda, Thudium, Rebekka F., Jensen, Jens Ulrik S., Rezahosseini, Omid, and Nielsen, Susanne D.

Abstract

Before introducing combination antiretroviral therapy (cART), a higher prevalence of emphysema in people living with HIV (PLWH) than in the background population was reported. This systematic literature review aimed to investigate the prevalence of emphysema in PLWH and to compare the prevalence between PLWH and controls in the current cART era. A systematic literature search was conducted in PubMed, EMBASE, Scopus, and Web of Science (WOS), searching for “human immunodeficiency virus (HIV)” and “emphysema” from January 1, 2000 to March 10, 2021. Eligible studies were published after the introduction of cART, included PLWH, and reported the prevalence of emphysema. A total of 17 studies were included, and nine studies also included controls. The weighted average prevalence of emphysema in PLWH was 23% (95% CI: 16–30). In studies including both PLWH and controls the weighted average prevalence were 22% (95% CI: 10–33) and 9.7% (95% CI: 2.3–17), respectively (p = 0.052). The prevalence of emphysema in never-smoking PLWH and controls was just reported in one study and was 18 and 4%, respectively (p < 0.01). Thirteen of the studies had a moderate risk of bias, mainly due to selection of patients. A tendency to higher prevalence of emphysema was found in PLWH in comparison to controls in the current cART era. However, in the included studies, the definition of emphysema varied largely. Thus, to have a clear overview of the prevalence, further studies with well-designed cohorts of PLWH and controls are warranted.

Published
2022

37. Incidence and severity of SARS-CoV-2 infections in liver and kidney transplant recipients in the post-vaccination era:Real-life data from Denmark

Author

Hamm, Sebastian Rask, Rezahosseini, Omid, Møller, Dina Leth, Loft, Josefine Amalie, Poulsen, Johan Runge, Knudsen, Jenny Dahl, Pedersen, Martin Schou, Schønning, Kristian, Harboe, Zitta Barrella, Rasmussen, Allan, Sørensen, Søren Schwartz, Nielsen, Susanne Dam, Hamm, Sebastian Rask, Rezahosseini, Omid, Møller, Dina Leth, Loft, Josefine Amalie, Poulsen, Johan Runge, Knudsen, Jenny Dahl, Pedersen, Martin Schou, Schønning, Kristian, Harboe, Zitta Barrella, Rasmussen, Allan, Sørensen, Søren Schwartz, and Nielsen, Susanne Dam

Abstract

Coronavirus disease 2019 (COVID-19) caused by SARS-CoV-2 has been associated with a high risk of adverse outcomes in solid organ transplant (SOT) recipients in the pre-vaccination era. In this retrospective cohort study, we examined the incidence and severity of COVID-19 in kidney and liver transplant recipients in Denmark in the post-vaccination era, from December 27, 2020, to December 27, 2021. We included 1428 SOT recipients with 143 cases of first-positive SARS-CoV-2 PCR test. The cumulative incidence of first-positive SARS-CoV-2 PCR test 1 year after initiation of vaccination was 10.4% (95% CI: 8.8–12.0), and the incidence was higher in kidney than in liver transplant recipients (11.6% [95% CI: 9.4–13.8] vs. 7.4% [95% CI: 5.1–9.8], p =.009). After the first-positive SARS-CoV-2 PCR test, the hospitalization rate was 31.5% (95% CI: 23.9–39.1), and 30-day all-cause mortality was 3.7% (95% CI: 0.5–6.8). Hospitalization was lower in vaccinated than in unvaccinated SOT recipients (26.4% [95% CI: 18.1–34.6] vs. 48.5% [95% CI: 31.4–65.5], p =.011), as was mortality (1.8% [95% CI: 0.0–4.3] vs. 9.1% [95% CI: 0.0–18.9], p =.047). In conclusion, SOT recipients remain at high risk of adverse outcomes after SARS-CoV-2 infections, with a lower risk observed in vaccinated than in unvaccinated SOT recipients.

Published
2022

38. Characteristics and Outcomes of Patients with Delftia acidovorans Infections:a Retrospective Cohort Study

Author

Højgaard, Signe Marie Mehl, Rezahosseini, Omid, Knudsen, Jenny Dahl, Fuglebjerg, Natascha Josephine Ulstrand, Skov, Marianne, Nielsen, Susanne Dam, Harboe, Zitta Barrella, Højgaard, Signe Marie Mehl, Rezahosseini, Omid, Knudsen, Jenny Dahl, Fuglebjerg, Natascha Josephine Ulstrand, Skov, Marianne, Nielsen, Susanne Dam, and Harboe, Zitta Barrella

Abstract

Delftia acidovorans (D. acidovorans) is a Gram-negative bacteria and an uncommon cause of human infections. This retrospective cohort study investigated clinical and microbiological characteristics and outcomes of patients with D. acidovorans infections. We included patients with culture-confirmed D. acidovorans infections attending Rigshospitalet, during 2002-2020. Fifty-nine patients with a median interquartile ranges (IQR) age of 47 (15-67) years were included. Thirty-five (59%) were males, and 57 (97%) had at least one comorbidity, including 25 (42%) with solid or hematologic malignancies. Eight (14%) were admitted to ICU, and 15 (25%) died within 365 days after infection. Persistent infection was found in 4 (6.8%) patients, and 41 (70%) had polymicrobial cultures, mainly with Pseudomonas spp. and Stenotrophomonas maltophilia. More than 85% of the D. acidovorans isolates were susceptible to meropenem or ceftazidime. Although, 88% and 62% of the isolates were resistant to gentamicin and colistin, respectively. D. acidovorans infections mainly affect patients with preexisting comorbidities, including malignancies. In the first year, all-cause mortality is considerable, polymicrobial cultures are common, and meropenem or cephalosporins with antipseudomonal activity could be the antibiotics of choice. IMPORTANCE Delftia acidovorans (D. acidovorans) is a Gram-negative bacteria that can cause infection in immunocompetent and immunocompromised individuals. The current knowledge comes mainly from case reports and case series. In this retrospective cohort study, we found that D. acidovorans infections mainly affect male patients with preexisting comorbidities, including malignancies. Persistent infections were not common, and most of the patients had polymicrobial cultures, mainly with Pseudomonas spp. and Stenotrophomonas maltophilia. More than 85% of the D. acidovorans isolates were susceptible to meropenem or ceftazidime. In contrast, 88% and 62% of the isolates we

Published
2022

39. Achromobacter spp. in a Cohort of Non-Selected Pre-and Post-Lung Transplant Recipients

Author

Crone, Cornelia Geisler, Rezahosseini, Omid, Schultz, Hans Henrik Lawaetz, Qvist, Tavs, Johansen, Helle Krogh, Nielsen, Susanne Dam, Perch, Michael, Crone, Cornelia Geisler, Rezahosseini, Omid, Schultz, Hans Henrik Lawaetz, Qvist, Tavs, Johansen, Helle Krogh, Nielsen, Susanne Dam, and Perch, Michael

Abstract

Achromobacter is an opportunistic pathogen that mainly causes chronic lung infections in cystic fibrosis (CF) patients and is associated with increased mortality. Little is known about Achromobacter spp. in the lung transplant recipient (LTXr) population. We aimed at describing rates of Achromobacter spp. infection in LTXr prior to, in relation to, and after transplantation, as well as all-cause mortality proportion in infected and uninfected LTXr. We included 288 adult LTXr who underwent lung transplantation (LTX) between 1 January 2010 and 31 December 2019 in Denmark. Bronchoalveolar lavage was performed at regular intervals starting two weeks after transplantation. Positive cultures of Achromobacter spp. were identified in nationwide microbiology registries, and infections were categorized as persistent or transient, according to the proportion of positive cultures. A total of 11 of the 288 LTXr had transient (n = 7) or persistent (n = 4) Achromobacter spp. infection after LTX; CF was the underlying disease in 9 out of 11 LTXr. Three out of the four patients, with persistent infection after LTX, also had persistent infection before LTX. The cumulative incidence of the first episode of infection one year after LTX was 3.8% (95% CI: 1.6–6.0). The incidence rates of transient and persistent infection in the first year after LTX were 27 (12–53) and 15 (5–37) per 1000 person-years of follow-up, respectively. The all-cause mortality proportion one year after LTX was 27% in the Achromobacter spp. infected patients and 12% in the uninfected patients (p = 0.114). Achromobacter spp. mainly affected LTXr with CF as the underlying disease and was rare in non-CF LTXr. Larger studies are needed to assess long-term outcomes of Achromobacter spp. in LTXr.

Published
2022

41. Efficacy, immunogenicity, and evidence for best-timing of pneumococcal vaccination in splenectomized adults:a systematic review

Author

Lenzing, Emil, Rezahosseini, Omid, Burgdorf, Stefan Kobbelgaard, Nielsen, Susanne Dam, Harboe, Zitta Barrella, Lenzing, Emil, Rezahosseini, Omid, Burgdorf, Stefan Kobbelgaard, Nielsen, Susanne Dam, and Harboe, Zitta Barrella

Abstract

Introduction: Streptococcus pneumoniae is the most frequent cause of overwhelming post-splenectomy infections. Pneumococcal vaccination is generally recommended for splenectomized individuals. However, most of our knowledge comes from a few observational studies or small randomized clinical trials. We conducted this systematic review to assess the evidence of efficacy, antibody response, and the best timing for pneumococcal vaccination in splenectomized individuals. Areas covered: The systematic review was conducted according to the PRISMA guidelines. We screened 489 articles, included 21 articles, and assessed the risk of bias using Cochrane RoB 2 and ROBINS-I. We summarized the findings narratively due to the heterogeneity of the studies. Expert opinion: Splenectomized individuals seem to have adequate antibody responses to pneumococcal vaccines. No differences in antibody responses were observed compared to healthy controls, except in one study. The studies were heterogeneous, and the majority had moderate to high degree of bias. There is a lack of clinical evidence for efficacy and best timing of pneumococcal vaccination in splenectomized individuals. Randomized clinical trials addressing these issues are needed.

Published
2022

42. Bacterial and fungal bloodstream infections in solid organ transplant recipients:results from a Danish cohort with nationwide follow-up

Author

Møller, Dina Leth, Sørensen, Søren Schwartz, Perch, Michael, Gustafsson, Finn, Rezahosseini, Omid, Knudsen, Andreas Dehlbæk, Scheike, Thomas, Knudsen, Jenny Dahl, Lundgren, Jens, Rasmussen, Allan, Nielsen, Susanne Dam, Møller, Dina Leth, Sørensen, Søren Schwartz, Perch, Michael, Gustafsson, Finn, Rezahosseini, Omid, Knudsen, Andreas Dehlbæk, Scheike, Thomas, Knudsen, Jenny Dahl, Lundgren, Jens, Rasmussen, Allan, and Nielsen, Susanne Dam

Abstract

Objectives: Bloodstream infections (BSI) are prevalent after solid organ transplantation (SOT). In this study, we aimed to investigate the incidence and risk factors for BSI in the first 5 years post-transplantation. Methods: The study included 1322 SOT (kidney, liver, lung and heart) recipients transplanted from 2010 to 2017 with a total of 5616 years of follow-up. Clinical characteristics and microbiology were obtained from the Centre of Excellence for Personalized Medicine of Infectious Complications in Immune Deficiency (PERSIMUNE) data repository with nationwide follow-up. Incidence was investigated in the different SOT groups. Risk factors associated with BSI were assed in the combined group in time-updated multivariable Cox regressions. Results: The cumulative incidence of first BSI in the first 5 years post-transplantation differed in the SOT groups with a lower incidence in heart transplant recipients than in the other SOT groups (heart: 4.4%, CI 0.0–9.7%, vs. kidney: 24.6%, CI 20.9–28.2%, liver: 24.7%, CI 19.4–29.9%, and lung: 19.6%, CI 14.5–24.8%, p <0.001). Age above 55 years (HR 1.71, CI 1.2–2.4, p=0.002) and higher Charlson comorbidity index score (HR per unit increase: 1.25, CI 1.1–1.4, p<0.001) at transplantation, current cytomegalovirus (CMV) infection (HR 4.5, CI 2.6–7.9, p<0.001) and current leucopenia (HR 13.3, CI 3.7–47.9, p<0.001) were all associated with an increased risk of BSI. Conclusion: In SOT recipients, the incidence of BSI differed with the type of transplanted organ. Risk of BSI was higher in older recipients and in recipients with comorbidity, current CMV infection or leucopenia. Thus, increased attention towards BSI in recipients with these characteristics is warranted.

Published
2022

43. The Epidemiological, Clinical, Mycological, and Pathological Features of Rhino-cerebral Mucormycosis: A Systematic Review

Author

Salehi, Mohammadreza, primary, Mahmoudi, Shahram, additional, Rezahosseini, Omid, additional, Hashemi, Sayed Jamal, additional, Ahmadikia, Kazem, additional, Aala, Farzad, additional, Khajavirad, Nasim, additional, Alijani, Neda, additional, Izadi, Alireza, additional, Getso, Muhammad Ibrahim, additional, Abdollahi, Alireza, additional, Salami, Arezoo, additional, Khatami, Seyedeh Rana, additional, Adibimehr, Alireza, additional, Hedayat Yaghoobi, Mojtaba, additional, Sabahi, Mohammadmahdi, additional, Pazooki, Behshad, additional, Yazdi, Farhad, additional, Zebardast, Jayran, additional, Seifi, Arash, additional, Hasan Nezhad, Malihe, additional, Mardani, Masoud, additional, and Khodavaisy, Sadegh, additional

Published
2022
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48. Risk Factors for Being Seronegative following SARS-CoV-2 Infection in a Large Cohort of Health Care Workers in Denmark

Author

Johannesen, Caroline Klint, primary, Rezahosseini, Omid, additional, Gybel-Brask, Mikkel, additional, Kristensen, Jonas Henrik, additional, Hasselbalch, Rasmus Bo, additional, Pries-Heje, Mia Marie, additional, Nielsen, Pernille Brok, additional, Knudsen, Andreas Dehlbæk, additional, Fogh, Kamille, additional, Norsk, Jakob Boesgaard, additional, Andersen, Ove, additional, Jensen, Claus Antonio Juul, additional, Torp-Pedersen, Christian, additional, Rungby, Jørgen, additional, Ditlev, Sisse Bolm, additional, Hageman, Ida, additional, Møgelvang, Rasmus, additional, Dessau, Ram B., additional, Sørensen, Erik, additional, Harritshøj, Lene Holm, additional, Folke, Fredrik, additional, Sten, Curt, additional, Møller, Maria Elizabeth Engel, additional, Engsig, Frederik Neess, additional, Ullum, Henrik, additional, Jørgensen, Charlotte Sværke, additional, Ostrowski, Sisse R., additional, Bundgaard, Henning, additional, Iversen, Kasper Karmark, additional, Fischer, Thea Kølsen, additional, and Nielsen, Susanne Dam, additional

Published
2021
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49. Pneumocystis jirovecii pneumonia in liver transplant recipients in an era of routine prophylaxis

Author

Andreasen, Philip B., primary, Rezahosseini, Omid, additional, Møller, Dina L., additional, Wareham, Neval E., additional, Thomsen, Magda T., additional, Houmami, Ranya, additional, Knudsen, Andreas D., additional, Knudsen, Jenny, additional, Kurtzhals, Jørgen A. L., additional, Rostved, Andreas A., additional, Pedersen, Christian R., additional, Rasmussen, Allan, additional, and Nielsen, Susanne D., additional

Published
2021
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50. An Observational Prospective Cohort Study of Incidence and Outcome of Streptococcus pneumoniae and Hemophilus influenzae Infections in Adult Solid Organ Transplant Recipients

Author

Rezahosseini, Omid, primary, Møller, Dina Leth, additional, Sørensen, Søren Schwartz, additional, Perch, Michael, additional, Gustafsson, Finn, additional, Gelpi, Marco, additional, Knudsen, Jenny, additional, Helleberg, Marie, additional, Rasmussen, Allan, additional, Nielsen, Susanne Dam, additional, and Harboe, Zitta Barrella, additional

Published
2021
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