1. Inflammatory Markers Associated With Subclinical Coronary Artery Disease: The Multicenter AIDS Cohort Study.
- Author
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Bahrami, Hossein, Budoff, Matthew, Haberlen, Sabina A, Rezaeian, Pantea, Ketlogetswe, Kerunne, Tracy, Russell, Palella, Frank, Witt, Mallory D, McConnell, Michael V, Kingsley, Lawrence, and Post, Wendy S
- Subjects
Humans ,HIV Infections ,Coronary Stenosis ,Tumor Necrosis Factor-alpha ,C-Reactive Protein ,Intercellular Adhesion Molecule-1 ,Receptors ,Tumor Necrosis Factor ,Interleukin-6 ,Coronary Angiography ,Adult ,Aged ,Middle Aged ,Male ,Coronary Artery Disease ,Vascular Calcification ,Multimodal Imaging ,Biomarkers ,Computed Tomography Angiography ,HIV ,HIV infection ,atherosclerosis ,cardiac biomarkers ,cardiac computed tomography ,coronary artery calcium ,coronary artery disease ,coronary computed tomography scan ,epidemiology ,inflammation ,Cardiovascular ,HIV/AIDS ,Atherosclerosis ,Heart Disease ,Clinical Research ,Heart Disease - Coronary Heart Disease ,Cardiorespiratory Medicine and Haematology - Abstract
BackgroundDespite evidence for higher risk of coronary artery disease among HIV+ individuals, the underlying mechanisms are not well understood. We investigated associations of inflammatory markers with subclinical coronary artery disease in 923 participants of the Multicenter AIDS Cohort Study (575 HIV+ and 348 HIV- men) who underwent noncontrast computed tomography scans for coronary artery calcification, the majority (n=692) also undergoing coronary computed tomography angiography.Methods and resultsOutcomes included presence and extent of coronary artery calcification, plus computed tomography angiography analysis of presence, composition, and extent of coronary plaques and severity of coronary stenosis. HIV+ men had significantly higher levels of interleukin-6 (IL-6), intercellular adhesion molecule-1, C-reactive protein, and soluble-tumor necrosis factor-α receptor (sTNFαR) I and II (all P
- Published
- 2016