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2. Viral clade is associated with severity of symptomatic genotype 3 hepatitis E virus infections in Belgium, 2010–2018

Author

Peeters, Michael, Schenk, Julie, De Somer, Thomas, Roskams, Tania, Locus, Tatjana, Klamer, Sofieke, Subissi, Lorenzo, Suin, Vanessa, Delwaide, Jean, Stärkel, Peter, De Maeght, Stéphane, Willems, Philippe, Colle, Isabelle, Van Hoof, Marc, Van Acker, Jos, Van Steenkiste, Christophe, Moreno, Christophe, Janssens, Filip, Reynders, Marijke, Steverlynck, Matthias, Verlinden, Wim, Lasser, Luc, de Galocsy, Chantal, Geerts, Anja, Maus, Jeroen, Gallant, Marie, Van Outryve, Steven, Marot, Astrid, Reynaert, Hendrik, Decaestecker, Jochen, Bottieau, Emmanuel, Schreiber, Jonas, Mulkay, Jean-Pierre, de Goeij, Sébastien, Salame, Mikhaël, Dooremont, Diederik, Dastis, Sergio Negrín, Boes, Juul, Nijs, Jochen, Beyls, Jan, Hens, Niel, Nevens, Frederik, Van Gucht, Steven, and Vanwolleghem, Thomas

Published
2023
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3. Human iPSC-derived liver co-culture spheroids to model liver fibrosis

Author

Cools, Laura, primary, Kazemzadeh Dastjerd, Mina, additional, Smout, Ayla, additional, Merens, Vincent, additional, Yang, Yuwei, additional, Reynaert, Hendrik, additional, Messaoudi, Nouredin, additional, De Smet, Vincent, additional, Kumar, Manoj, additional, Verhulst, Stefaan, additional, Verfaillie, Catherine, additional, and van Grunsven, Leo A., additional

Published
2024
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6. Selonsertib for patients with bridging fibrosis or compensated cirrhosis due to NASH: Results from randomized phase III STELLAR trials

Author

Gadano, Adrian, Martins, Marcelo, Angus, Peter, Bate, John, Danta, Mark, George, Jacob, Hodge, Alexander, Kontorinis, Nickolas, Roberts, Stuart, Sanagapalli, Santosh, Skoien, Richard, Thompson, Alexander, Zekry, Amany, Stauber, Rudolf, Trauner, Michael, Moreno, Christophe, Reynaert, Hendrik, Verbeke, Len, Silva, Mario Reis Alvares da, Parise, Edison, Oliveira, Claudia Pinto Marques Souza de, Araujo, Roberta Chaves, Martinelli, Ana de Lourdes Candolo, Borman, Meredith, Chandok, Natasha, Elkhashab, Magdy, Fraser, Hughie, Kaita, Kelly, Ma, Mang, Marotta, Paul, Ramji, Alnoor, Tam, Edward, Yoshida, Eric, Swain, Mark, Sebastiani, Giada, Petrunia, Denis, Abergel, Armando, Anty, Rodolphe, Bourlière, Marc, Boursier, Jérôme, Bureau, Christophe, Castera, Laurent, Habersetzer, François, Hézode, Christophe, Ledinghen, Victor De, Leroy, Vincent, Loustaud-Ratti, Véronique, Mathurin, Philippe, Pol, Stanislas, Zoulim, Fabien, Hinrichsen, Holger, Ingiliz, Patrick, Lammert, Frank, Manns, Michael, Schattenberg, Jörn, Schiefke, Ingolf, Trautwein, Christian, Zeuzem, Stefan, Hui, Aric, Li, King-Kong, Wong, Vincent, Acharya, Subrat, Chowdhury, Abhijit, Duseja, Ajay, Kapoor, Dharmesh, Mukewar, Shrikant, Sarin, Shiv, Shah, Samir, Shalimar, Sood, Ajit, Tantry, BV, Ben-Ari, Ziv, Katchman, Helena, Safadi, Rifaat, Veitsman, Ella, Zuckerman, Eli, Brunetto, Maurizia, Lampertico, Pietro, Mangia, Alessandra, Akahane, Takemi, Akuta, Norio, Eguchi, Yuichiro, Fujiyama, Shigetoshi, Genda, Takuya, Hiasa, Yoichi, Ido, Akio, Ikeda, Fusao, Ikegami, Tadashi, Imajo, Kento, Itoh, Yoshito, Iwasa, Motoh, Karino, Yoshiyasu, Kato, Naoya, Kawaguchi, Takumi, Kawanaka, Miwa, Kido, Masahiro, Kobayashi, Tomoo, Kurosaki, Masayuki, Matsuzaki, Yasushi, Mita, Eiji, Mizukoshi, Eishiro, Nakahara, Takashi, Nomura, Hideyuki, Notsumata, Kazuo, Okanoue, Takeshi, Saito, Satoshi, Sakugawa, Hiroshi, Suzuki, Yoshiyuki, Takaguchi, Koichi, Takaki, Akinobu, Takashima, Tomoyuki, Tanaka, Saiyu, Tsuji, Keiji, Ueno, Yoshiyuki, Umemura, Takeji, Uto, Hirofumi, Yamashita, Nobuyuki, Yanase, Mikio, Yatsuhashi, Hiroshi, Yoneda, Masashi, Chan, Wah Kheong, Tan, Soek Siam, Garza, Laura Cisneros, Ladron De Guevara Cetina, Alma, Angeles, Rocio Guadalupe Vargas, Silva, Francisca Martinez, Van Erpecum, Karel, Orr, David, Jabłkowski, Maciej, Jaroszewicz, Jerzy, Ramos, Jose, Ahmed, Taufique, Ang, Tiing, Dan, Yock young, Goh, Boon Bee, Kaliyaperumal, Kalaiyarasi, Yip, Cherng Hann, Baik, Soon Koo, Jang, Byoung Kuk, Jun, Dae Won, Kim, Won, Kim, Hyung Joon, Kim, Ji Hoon, Lee, Kwan Sik, Lee, Chun Kyon, Lim, Young-Suk, Park, Jun Yong, Tak, Won Young, Augustin, Salvador, Perez, Salvador Benlloch, Caballeria, Juan, Luis, Jose, Panero, Calleja, Rodríguez, Jose Carrión, Garcia, Javier Crespo, Samaniego, Javier Garcia, Gibert, Pere Ginès, Prieto, Martin, Gomez, Manuel Romero, Turnes, Juan, Dufour, Jean-Francois, Moriggia, Alberto, Sheen, I-Shyan, Kao, Jia-Horng, Cheng, Pin-Nan, Huang, Jee-Fu, Yang, Sheng-Shun, Su, Wei-Wen, Chen, Chi-Yi, Chien, Rong-Nan, Lo, Gin-Ho, Chu, Chi-Jen, Wang, Horng-Yuan, Hu, Jui-Ting, Huang, Yi Wen, Agarwal, Kosh, Allison, Michael, Anstee, Quentin, Austin, Andrew, Fowell, Andrew, Ch'ng, Chin Lye, Manousou, Pinelopi, Newsome, Philip, Ryder, Stephen, Shankar, Arun, Abdelmalek, Manal, Abrams, Gary, Aguilar, Humberto, Alam, Imtiaz, Alba, Laura, Alkhouri, Naim, Allen, Alina, Aqel, Bashar, Balart, Luis, Barritt, A. Sidney, IV, Behari, Jaideep, Bennett, Michael, Bernstein, David, Bhandari, Bal Raj, Bonacini, Maurizio, Borg, Brian, Brown, Kimberly, Bzowej, Natalie, Caldwell, Stephen, Chami, Tawfik, Coates, Allan, Cueli, Adolfo, Davis, Mitchell, deLemos, Andrew, Desai, Archita, Dunn, Winston, Ferreira, Nelson, Fine, Michael, Firpi-Morell, Roberto, Freedland, Curtis, Freilich, Bradley, Fuchs, Michael, Galambos, Michael, Gallegos-Orozco, Juan, Galler, Greg, Ghali, Maged, Ghalib, Reem, Gill, Satinder, Gillis, Marcum, Gilroy, Richard, Gordon, Stuart, Gunn, Nadege, Halegoua-DeMarzio, Dina, Hassan, Mohamed, Hassanein, Tarek, Herring, Robert, Jr., Hong, John, Huang, Jonathan, Kabler, Heidi, Kayali, Zeid, Knapple, Whitfield, Kolli, Geetha, Kowdley, Kris, Krause, Richard, Lawitz, Eric, Lidofsky, Steven, Lim, Joseph, Lipkis, Donald, Loomba, Rohit, Mahgoub, Amar, Malespin, Miguel, Manch, Richard, Mannis, Steven, Manos, Paul, McDonald, Thomas, McKenzie, Mark, Mena, Edward, Merriman, Raphael, Moehlen, Martin William, Montgomery, Richard, Murphy, Robert, Natarajan, Yamini, Neff, Guy, Noureddin, Mazen, Ortiz-Lasanta, Grisell, Pagadala, Mangesh, Patel, Keyur, Patton, Heather, Peyton, Adam, Pimstone, Neville, Poulos, John, Pound, David, Pyrsopoulos, Nikolaos, Rafiq, Nila, Ravendhran, Natarajan, Ravinuthala, Ravi, Reddy, K. Rajendar, Reindollar, Robert, Reynolds, Justin, Rinella, Mary, Rizvi, Syed, Rockey, Don, Rodriguez-Perez, Federico, Ruane, Peter, Rubin, Raymond, Ryan, Michael, Saeian, Kia, Sanyal, Arun, Sarkar, Souvik, Scanga, Andrew, Schiff, Eugene, Schmidt, Warren, Schneider, Jeffrey, Sepe, Thomas, Shah, Dhiren, Shaikh, Obaid, Shankar, Uday, Sheikh, Aasim, Sheikh, Muhammad, Sherman, Kenneth, Shiffman, Mitchell, Siddique, Asma, Smith, Matthew, Suarez, Rosa, Talal, Andrew, Te, Helen, Tekola, Bezawit, Tetri, Brent, Thuluvath, Paul, Toro, Doris, Torres, Dawn, Trinh, Huy, Trotter, James, Vento, Angel, Vierling, John, Vuppalanchi, Raj, Waters, Michael, Weisberg, Ilan, Wieland, Amanda, Williams, Alonzo, Younes, Ziad, Adams, Leon, Harding, Damian, Hodge, Alex, Kontorinis, Nick, Strasser, Simone, Thompson, Alex, Horsmans, Yves, Steenkiste, Christophe Van, Bailey, Robert, Giard, Jeanne-Marie, Montano-Loza, Aldo, Puglia, Marco, Tsoi, Keith, Larrey, Dominique, Nguyen-Khac, Eric, Ratziu, Vlad, Spengler, Ulrich, Wiegand, Johannes, Hui, Aric Josun, Acharya, Subrat Kumar, Sarin, Shiv Kumar, Tantry, Vishwanath, Braun, Marius, Hazzan, Rawi, Lurie, Yoav, Colombo, Massimo, Fujii, Hideki, Hashimoto, Etsuko, Kato, Masaki, Ogawa, Koji, Takehara, Tetsuo, Tokushige, Katsutoshi, Garza, Laura Esthela Cisneros, Ladrón De Guevara, Alma Laura, Schultz, Michael, Janczewska, Ewa, Toro, Doris H., Jeong, Sook-Hyang, Kim, Yoon Jun, Lee, Jin-Woo, Ang, Tiing Leong, Bee, George Goh Boon, Benlloch, Salvador, Caballería, Juan, Calleja, José Luis, Rodríguez, Jose A. Carrión, Crespo, Javier, Diago, Moises, Fernandez-Rodriguez, Conrado, García-Samaniego, Javier, Ginès, Pere, Romero, Manuel, Dufour, Jean-François, Alazawi, William, Ch'ng, Chin-Lye, Forton, Daniel, Priest, Matthew, Sheridan, David, Ankoma-Sey, Victor, Balakrishnan, Maya, Bambha, Kiran, Barritt, A. Sidney, Bhandari, Bal, Brandman, Danielle, Chang, Charissa, Corey, Kathleen, Feldman, Michael, Gholam, Pierre, Goff, John, Marzio, Dina Halegoua-De, Harrison, Stephen, Hellstern, Paul, Jr., Herring, Robert, Iyer, Rajalakshmi, Jakiche, Antoine, Kohli, Anita, Krok, Karen, Kugelmas, Marcelo, Kumar, Sonal, Lai, Michelle, Mahmoud, Mitchell, Mantry, Parvez, Marsano, Luis, Nguyen, Tuan, Park, James, Patton, Heather M., Pockros, Paul, Reddy, Rajender, Rodriguez, Miguel, Sarles, Harry, Satapathy, Sanjaya, Sedghi, Shahriar, Shah, Nikunj, Sheikh, Muhammad Yasin, Sigal, Samuel, Stanca, Carmen, Steinbook, Michael, Szabo, Gyongyi, Terrault, Norah, Tong, Myron, Victor, David, Zervos, Xaralambos, Harrison, Stephen A., Wong, Vincent Wai-Sun, Caldwell, Stephen H., Shiffman, Mitchell L., Camargo, Marianne, Li, Georgia, Kersey, Kathryn, Jia, Catherine, Zhu, Yanni, Djedjos, C. Stephen, Subramanian, G. Mani, Myers, Robert P., Anstee, Quentin M., Romero-Gomez, Manuel, Goodman, Zachary, Lawitz, Eric J., and Younossi, Zobair

Published
2020
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13. OUTCOMES OF EUS-GUIDED GASTROENTEROSTOMY VERSUS SURGICAL GASTROENTEROSTOMY AND ENTERAL STENTING FOR GASTRIC OUTLET OBSTRUCTION: A LARGE TWO-CENTER INTERNATIONAL STUDY

Author

Jaruvongvanich, Veeravich, primary, Mahmoud, Tala, additional, Abu Dayyeh, Barham K., additional, Chandrasekhara, Vinay, additional, Law, Ryan, additional, Levy, Michael J., additional, Storm, Andrew C., additional, Vargas, Eric J., additional, Marya, Neil B., additional, Abboud, Donna Maria, additional, Ghazi, Rabih, additional, Matar, Reem, additional, Rapaka, Babusai, additional, Buttar, Navtej S., additional, Truty, Mark J., additional, Reynaert, Hendrik, additional, Messaoudi, Nouredin, additional, Aerts, Maridi, additional, and Kunda, Rastislav, additional

Published
2022
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14. Viral clade is associated with severity of symptomatic genotype 3 Hepatitis E virus infections in Belgium, 2010-2018.

Author

UCL - SSS/IREC/MONT - Pôle Mont Godinne, UCL - (MGD) Service de gastro-entérologie, Peeters, Michael, Schenk, Julie, De Somer, Thomas, Roskams, Tania, Locus, Tatjana, Klamer, Sofieke, Subissi, Lorenzo, Suin, Vanessa, Delwaide, Jean, Stärkel, Peter, De Maeght, Stéphane, Willems, Philippe, Colle, Isabelle, Van Hoof, Marc, Van Acker, Jos, Van Steenkiste, Christophe, Moreno, Christophe, Janssens, Filip, Reynders, Marijke, Steverlynck, Matthias, Verlinden, Wim, Lasser, Luc, de Galocsy, Chantal, Geerts, Anja, Maus, Jeroen, Gallant, Marie, Van Outryve, Steven, Marot, Astrid, Reynaert, Hendrik, Decaestecker, Jochen, Bottieau, Emmanuel, Schreiber, Jonas, Mulkay, Jean-Pierre, de Goeij, Sébastien, Salame, Mikhaël, Dooremont, Diederik, Dastis, Sergio Negrín, Boes, Juul, Nijs, Jochen, Beyls, Jan, Hens, Niel, Nevens, Frederik, Van Gucht, Steven, Vanwolleghem, Thomas, Belgian Association for the Study of the Liver, UCL - SSS/IREC/MONT - Pôle Mont Godinne, UCL - (MGD) Service de gastro-entérologie, Peeters, Michael, Schenk, Julie, De Somer, Thomas, Roskams, Tania, Locus, Tatjana, Klamer, Sofieke, Subissi, Lorenzo, Suin, Vanessa, Delwaide, Jean, Stärkel, Peter, De Maeght, Stéphane, Willems, Philippe, Colle, Isabelle, Van Hoof, Marc, Van Acker, Jos, Van Steenkiste, Christophe, Moreno, Christophe, Janssens, Filip, Reynders, Marijke, Steverlynck, Matthias, Verlinden, Wim, Lasser, Luc, de Galocsy, Chantal, Geerts, Anja, Maus, Jeroen, Gallant, Marie, Van Outryve, Steven, Marot, Astrid, Reynaert, Hendrik, Decaestecker, Jochen, Bottieau, Emmanuel, Schreiber, Jonas, Mulkay, Jean-Pierre, de Goeij, Sébastien, Salame, Mikhaël, Dooremont, Diederik, Dastis, Sergio Negrín, Boes, Juul, Nijs, Jochen, Beyls, Jan, Hens, Niel, Nevens, Frederik, Van Gucht, Steven, Vanwolleghem, Thomas, and Belgian Association for the Study of the Liver

Abstract

Hepatitis E virus (HEV) genotype (gt) 3 infections are prevalent in high income countries and display a wide spectrum of clinical presentations. Host - but not viral - factors are reported to be associated with worse clinical outcomes. Demographic, clinical and biochemical data of laboratory confirmed HEV infections (by PCR and/or a combination of IgM and IgG serology) at the Belgian National Reference Centre between January 2010 and June 2018 were collected using standardised case report forms. Genotyping was based on HEV Open Reading Frame 2 sequences. Serum CXCL10 levels were measured by a magnetic bead-based assay. H&E staining was performed on liver biopsies. 274 HEV-infected patients were included. Subtype assignment was possible for 179/218 viremic cases, confirming gt3 as dominant with an almost equal representation of clades abchijklm and efg. An increased hospitalisation rate and higher peak serum levels of alanine aminotransferase, bilirubin and alkaline phosphatase were found in clade efg infected patients in univariate analyses. In multivariable analyses, clade efg infections remained more strongly associated with severe disease presentation than any of the previously identified host risk factors. It associated with a 2·1-fold higher risk of hospitalisation (95% CI=1·1-4·4, p-value (p)=0·034) and with a 68·2% fold higher peak of bilirubin levels (95% CI=13·3-149·9, p=0·010), independently of other factors included in the model. In addition, acute clade efg infections were characterised by higher serum CXCL10 levels (p = 0·0005) and a more pronounced liver necro-inflammatory activity (p = 0·022). In symptomatic HEV gt3 infections, clade efg is associated with a more severe disease presentation, higher serum CXCL10 levels and liver necro-inflammatory activity, irrespective of known host risk factors. Hepatitis E virus genotype 3 infections are prevalent in high income countries and display a wide spectrum of clinical presentations. We here analysed the ro

Published
2022

18. Proactive approach after endoscopic ultrasound guided gallbladder drainage with c with direct peroral cholecystoscopy and subsequent stent removal pending complete stone clearance

Author

Kunda, Rastislav, Aerts, Maridi, Messaoudi, Nouredin, Reynaert, Hendrik, Clinical sciences, Surgery, Gastroenterology, Internal Medicine, Supporting clinical sciences, Basic (bio-) Medical Sciences, Laboratory of Molecullar and Cellular Therapy, and Liver Cell Biology

Subjects
surgery, endoscopic ultrasound guided gallbladder drainage, gastroenterology, stone clearance, direct peroral cholecystoscopy
Published
2022

19. Intraductal ultrasound as diagnostic and mapping tool of biliary intraductal pathologies and their anatomical extent

Author

Kunda, Rastislav, Messaoudi, Nouredin, Aerts, Maridi, Reynaert, Hendrik, Clinical sciences, Surgery, Gastroenterology, Internal Medicine, Supporting clinical sciences, Basic (bio-) Medical Sciences, Laboratory of Molecullar and Cellular Therapy, and Liver Cell Biology

Subjects
surgery, billiary intraductal pathology, Mapping, diagnosis, gastroenterology, intraductal ultrasound
Published
2022

20. Interval cholecystectomy after endoscopic ultrasound guided gallbladder drainage with lumen-apposing metal stents

Author

Kunda, Rastislav, Messaoudi, Nouredin, Aerts, Maridi, Reynaert, Hendrik, Clinical sciences, Surgery, Gastroenterology, Internal Medicine, Supporting clinical sciences, Basic (bio-) Medical Sciences, Laboratory of Molecullar and Cellular Therapy, and Liver Cell Biology

Subjects
surgery, Interval cholecystectomy, endoscopic ultrasound guided gallbladder drainage, gastroenterology, lumen-apposing metal stents
Published
2022

21. The role of intraductal ultrasound in fluoroless biliopancreatic interventions

Author

Kunda, Rastislav, Aerts, Maridi, Messaoudi, Nouredin, Reynaert, Hendrik, Clinical sciences, Surgery, Gastroenterology, Internal Medicine, Supporting clinical sciences, Basic (bio-) Medical Sciences, Laboratory of Molecullar and Cellular Therapy, and Liver Cell Biology

Subjects
fluoroless biliopancreatic intervention, surgery, gastroenterology, radiation exposure, intraductal ultrasound
Published
2022

23. A profibrotic role for the orphan G-protein coupled receptor 176 during hepatic stellate cell activation

Author

De Smet, Vincent, Verhulst, Stefaan, Dewyse, Liza, Dastjerd, Mina Kazemzadeh, Reynaert, Hendrik, Halder, Georg, Mannaerts, Inge, van Grunsven, Leo A., Liver Cell Biology, Basic (bio-) Medical Sciences, Internal Medicine, Faculty of Medicine and Pharmacy, Gastroenterology, Laboratory of Molecullar and Cellular Therapy, and Translational Liver Cell Biology

Subjects
hepatology, orphan G-protein, hepatic stellate cell
Published
2021

24. Randomised clinical trial: alisporivir combined with peginterferon and ribavirin in treatment-naïve patients with chronic HCV genotype 1 infection (ESSENTIAL II)

Author

Zeuzem, S., Flisiak, R., Vierling, J. M., Mazur, W., Mazzella, G., Thongsawat, S., Abdurakhmanov, D., Van Kính, N., Calistru, P., Heo, J., Stanciu, C., Gould, M., Makara, M., Hsu, S.-J., Buggisch, P., Samuel, D., Mutimer, D., Nault, B., Merz, M., Bao, W., Griffel, L. H., Brass, C., Naoumov, N. V., Tanno, Hugo, Bessone, Fernando, Terg, Ruben, Frider, Bernardo, Bertuzzi, Romina, Desmond, Paul, Zekry, Amany, Weltman, Martin, George, Jacob, Crawford, Darrell, Matthews, Gail, Moreno, Christophe, Van Vlierberghe, Hans, Reynaert, Hendrik, Gould, Michael, Lee, Samuel, Ramji, Alnoor, Tam, Edward, Marotta, Paul, Yoshida, Eric, Wong, Florence, Feld, Jordan, Samuel, Didier, Marcellin, Patrick, Alric, Laurent, Zarski, Jean-Pierre, Zoulim, Fabien, Buggisch, Peter, Hinrichsen, Holger, Goeser, Tobias, Zeuzem, Stefan, Galle, Peter, Berg, Thomas, Schott, Eckart, Rasenack, Jens, Gerken, Guido, Wedemeyer, Hans, Tsang, Owen, Yuen, Man-Fung, Chan, Henry, Hui, Aric Josun, Makara, Mihaly, Tornai, Istvan, Gervain, Judit, Szalay, Ferenc, Varga, Marta, Horvath, Gabor, Hunyady, Bela, Vincze, Aron, Mazzella, Giuseppe, Gaeta, Giovanni Battista, Alberti, Alfredo, Colombo, Massimo, Andreone, Pietro, Rizzetto, Mario, Angelico, Mario, Craxi, Antonio, Picciotto, Antonino, Sacchi, Paolo, Vinci, Maria, Invernizzi, Pietro, Bruno, Savino, Heo, Jeong, Lee, Younjae, Cho, Mong, Han, Sangyoung, Lee, Jinwoo, Ahn, Sanghoon, Lim, Youngsuk, Hwang, Seonggyu, Sanchez, Juan, Muñoz, Linda, Maldonado, Hector, Mazur, Wlodzimierz, Flisiak, Robert, Jablkowski, Maciej, Kryczka, Wieslaw, Halota, Waldemar, Calistru, Petre, Prelipcean, Cristina, Musa, Manuela, Stanciu, Carol, Manuc, Mircea, Tanasescu, Coman, Dumitrascu, Dan, Abdurakhmanov, Djamal, Chulanov, Vladimir, Nikitin, Igor, Zhdanov, Konstantin, Esaulenko, Elena, Maevskaya, Marina, Znoyko, Olga, Lamoglia, Ricard Sola, Ferret, Maria Buti, Garcia-Samaniego, Javier, Gomez, Manuel Romero, Diago, Moises, Calleja, Jose Luis, Hsu, Shih-Jer, Chuang, Wan-Long, Hu, Tsung-Hui, Peng, Cheng-Yuan, Chen, Chi-Yi, Kao, Jia-Horng, Thongsawat, Satawat, Sukeepaisarnjaroen, Wattana, Piratvisuth, Teerha, Tanwandee, Tawesak, Komolmit, Piyawat, Agarwal, Kosh, Mutimer, David, Brown, Ashley, Foster, Graham, McPherson, Stuart, Ryder, Stephen, Poulos, John, Rustgi, Vinod, Lyche, Kip, Omarro, Steven, Vierling, John, Ghalib, Reem, Karnam, Umaprasanna, Peine, Craig, Galati, Joseph, Person, John, De La Torre, Andrew, Ravendhran, Natarajan, Mushahwar, Andria, OʼLeary, Jacqueline, Lee, William, Lawitz, Eric, Ankoma-Sey, Victor, King, John, Pound, David, Scarsella, Anthony, Thuluvath, Paul, Pockros, Paul, Mailliard, Mark, Shiffman, Mitchell, Sylvestre, Diana, Heiman, David, Jacobson, Ira, Bacon, Bruce, Dimitroff, James, Reindollar, Robert, Tobias, Hillel, Godofsky, Eliot, Rodriguez-Torres, Maribel, Bennett, Michael, Ben-Zvi, Jeffrey, Van, Kinh Nguyen, Dao, Long, Huu, Hoang Bui, Minh, Yen Lam, Le Thanh, Ly, and Van Long, Dao

Published
2015
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27. RECURRENT HEPATIC ENCEPHALOPATHY : BEYOND INFECTION AND GI BLEEDING

Author

Delaleeuwe, Isha Rita, Vlassenroot, Nemo, Buydens, Peter, François, Silke, Reynaert, Hendrik, Kindt, Sébastien, Faculty of Medicine and Pharmacy, Gastroenterology, Clinical sciences, Basic (bio-) Medical Sciences, Laboratory of Molecullar and Cellular Therapy, and Liver Cell Biology

Abstract

A 72-year-old female patient, known with cirrhosis Child Pugh B secondary to non-alcoholic steatohepatitis (NASH) and alcohol abuse, was admitted repeatedly since April 2020 due to hepatic encephalopathy (HE), with several episodes of deep coma requiring intubation and observation on the intensive care unit (ICU). Further history included hypothyroidism and type 2 diabetes mellitus. Apart from signs of cirrhosis physical examination was not contributive. Active, though minimal, alcohol consumption was reported during the initial hospitalization. Minimal ascites not amenable to aspiration, was noted by ultrasound. Infection, gastro-intestinal bleeding and portal vein thrombosis were actively and repeatedly excluded. Imaging, lumbar puncture and EEG ruled out central causes of encephalopathy. There was no evidence of hepatocellular carcinoma. Glucose levels were normal, although there was poor metabolic control of type 2 diabetes mellitus. Micronutrient deficiency were excluded. Because of hypothyroidism thyroid substitution was increased accordingly. Vitamin B1 substitution, diuretics and lactulose were initiated in hospital and continued upon discharge. Because of the recurrent episodes rifaximin was added. During a subsequent admission for HE levetiracetam was started because of epileptic activity on EEG. A transfer to a service residence was arranged to improve compliance to treatment. Nevertheless, 2 weeks later, the patient was readmitted for the fourth episode of altered mental state. An abdominal contrast-enhanced CT-scan identified recanalization of the umbilical vena with presence of a shunt between the portal and the deep venous system via the right iliac vena. Partial embolization was performed with subsequent improvement of mental state. HE is a feature of decompensated cirrhosis. It is associated with significant morbidity and mortality. In cases refractory to treatment, assessment of a portosystemic shunt is recommended. Around 60 % of patients remain free of hepatic encephalopathy three months after embolization, and 49-55 % after 1-2 years.

Published
2021

29. Impact of intensive enteral nutrition in association with corticosteroids in the treatment of severe alcoholic hepatitis: a multicenter randomized controlled trial: 141

Author

Moreno, Christophe, Trépo, Eric, Louvet, Alexandre, Degré, Delphine, Bastens, Boris, Hittelet, Axel, Piquet, Marie-Astrid, Laleman, Wim, Orlent, Hans, Lasser, Luc, Sersté, Thomas, Starkel, Peter, Dekoninck, Xavier, Dastis, Sergio Negrin, Delwaide, Jean, Colle, Isabelle, de Galocsy, Chantal, Francque, Sven M., Langlet, Philippe, Putzeys, Virginie, Reynaert, Hendrik, Gustot, Thierry, and Deltenre, Pierre

Published
2014

31. Stopping nucleos(t)ide analogue treatment in Caucasian hepatitis B patients after HBeAg seroconversion is associated with high relapse rates and fatal outcomes

Author

Van Hees, S., Bourgeois, S., Van Vlierberghe, H., Sersté, T., Francque, S., Michielsen, P., Sprengers, D., Reynaert, H., Henrion, J., Negrin Dastis, S., Delwaide, J., Lasser, L., Decaestecker, J., Orlent, H., Janssens, F., Robaeys, G., Colle, I., Stärkel, P., Moreno, C., Nevens, F., Vanwolleghem, T., Van Hees, Stijn, Bourgeois, Stefan, Van Vlierberghe, Hans, Sersté, Thomas, Francque, Sven, Michielsen, Peter, Sprengers, Dirk, Reynaert, Hendrik, Henrion, Jean, Negrin‐Dastis, Sergio, Delwaide, Jean, Lasser, Luc, Decaestecker, Jochen, Orlent, Hans, Janssens, Filip, Robaeys, Geert, Colle, Isabelle, Stärkel, Peter, Moreno, Christophe, Nevens, Frederik, Vanwolleghem, Thomas, Nuclear Medicine, Liver Cell Biology, Laboratory of Molecullar and Cellular Therapy, Basic (bio-) Medical Sciences, Faculty of Medicine and Pharmacy, Gastroenterology, Gastroenterology & Hepatology, and Belgian NA Stop Study Group

Subjects
Male, 0301 basic medicine, HBsAg, Antibodies, Viral, Gastroenterology, Cohort Studies, Fatal Outcome, 0302 clinical medicine, Recurrence, HEPATOCELLULAR-CARCINOMA, E-ANTIGEN, Medicine and Health Sciences, Pharmacology (medical), Hepatitis B e Antigens, ENTECAVIR TREATMENT, Pharmacology. Therapy, Nucleosides, Middle Aged, Hepatitis B, PREDICTS, Treatment Outcome, HBeAg, Seroconversion, Hepatocellular carcinoma, SUSTAINED VIROLOGICAL RESPONSE, Cohort, Original Article, Female, 030211 gastroenterology & hepatology, CLINICAL-PRACTICE GUIDELINES, Cohort study, Adult, Hepatitis B virus, medicine.medical_specialty, DISCONTINUATION, VIRUS-INFECTION, GAMMA-GLUTAMYL-TRANSFERASE, Antiviral Agents, 03 medical and health sciences, Hepatitis B, Chronic, SDG 3 - Good Health and Well-being, Fatal Outcomes from Stopping Nucleoside Analogues in Hepatitis B, Internal medicine, SEROCONVERSION, medicine, Humans, CONSOLIDATION THERAPY, Hepatology, business.industry, medicine.disease, digestive system diseases, Discontinuation, 030104 developmental biology, Withholding Treatment, Human medicine, business
Abstract

Background: Stopping nucleos(t)ide analogues (NA) after hepatitis B e antigen (HBeAg) seroconversion is associated with high relapse rates in Asian patients, but data in Caucasian cohorts are scarce. Clinical course, outcomes and immunological aspects of chronic hepatitis B infections differ substantially between distinct ethnicities. Aim: The aim of this study was to determine relapse rates, factors predicting relapse and clinical outcomes after nucleos(t)ide analogue cessation in a large, predominantly Caucasian cohort of chronic hepatitis B patients with nucleos(t)ide analogue-induced HBeAg seroconversion. Methods: This is a nationwide observational cohort study including HBeAg positive, mono-infected chronic hepatitis B patients with nucleos(t)ide analogue-induced HBeAg seroconversion from 18 centres in Belgium. Results: A total of 98 patients with nucleo(s)tide analogue-induced HBeAg seroconversion were included in the study. Of the 62 patients who stopped treatment after a median consolidation treatment of 8 months, 30 relapsed. Higher gamma-glutamyl transferase levels at both treatment initiation (HR 1.004; P = 0.001 per unit increment) and HBeAg seroconversion (HR 1.006; P = 0.013 per unit increment) were associated with an increased risk of clinically significant relapse in a multivariate Cox regression model. Treatment cessation led to liver-related death in 2 patients, of whom one showed a severe flare. Of the patients who continued treatment after HBeAg seroconversion, none relapsed or developed severe hepatic outcomes. Conclusion: Treatment withdrawal in Caucasian chronic hepatitis B patients after nucleos(t)ide analogue-induced HBeAg seroconversion results in viral relapses in more than half of patients with potential fatal outcomes. These real-world data further lend support to preferentially continue NA treatment after HBeAg seroconversion until HBsAg loss. Foundation Against Cancer Belgium, Grant/Award Number: 2014-087

Published
2018

32. Inhibition of placental growth factor activity reduces the severity of fibrosis, inflammation, and portal hypertension in cirrhotic mice

Author

Steenkiste, Christophe Van, Ribera, Jordi, Geerts, Anja, Pauta, Montse, Tugues, Sònia, Casteleyn, Christophe, Libbrecht, Louis, Olievier, Kim, Schroyen, Ben, Reynaert, Hendrik, van Grunsven, Leo A., Blomme, Bram, Coulon, Stephanie, Heindryckx, Femke, De Vos, Martine, Stassen, Jean Marie, Vinckier, Stefan, Altamirano, Jose, Bataller, Ramón, Carmeliet, Peter, Van Vlierberghe, Hans, Colle, Isabelle, and Morales-Ruiz, Manuel

Published
2011
Full Text
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34. Hepatitis E virus genotype 3 subtype dependent clinical outcomes in Belgium 2010–2018

Author

Peeters, Michael, primary, De Somer, Thomas, additional, Klamer, Sofieke, additional, Nevens, Frederik, additional, Delwaide, Jean-Pierre, additional, Stärkel, Peter, additional, Willems, Philippe, additional, De Maeght, Stéphane, additional, Moreno, Christophe, additional, Van Hoof, Marc, additional, Colle, Isabelle, additional, Van Steenkiste, Christophe, additional, Janssens, Filip, additional, Van Acker, Jos, additional, Marot, Astrid, additional, Bottieau, Emmanuel, additional, Reynders, Marijke, additional, De Galocsy, Chantal, additional, Lasser, Luc, additional, Steverlynck, Matthias, additional, Maus, Jeroen, additional, Verlinden, Wim, additional, Geerts, Anja, additional, Gallant, Marie, additional, Steven, Van Outryve, additional, Reynaert, Hendrik, additional, Mulkay, Jean-Pierre, additional, Decaestecker, Jochen, additional, Suin, Vanessa, additional, Negrin-Dastis, Sergio, additional, Beyls, Jan, additional, Nijs, Jochen, additional, Boes, Juul, additional, Van Gucht, Steven, additional, and Vanwolleghem, Thomas, additional

Published
2020
Full Text
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38. A SEROLOGICAL miRNA-BASED ALGORITHM (MIRFIB) FOR THE IDENTIFICATION OF SIGNIFICANT LIVER FIBROSIS IN PATIENTS WITH CHRONIC ALCOHOL ABUSE, NAFLD, AND VIRAL LIVER DISEASE

Author

Lambrecht, Joeri, Verhulst, Stefaan, Reynaert, Hendrik, van Grunsven, Leo A., Faculty of Medicine and Pharmacy, Basic (bio-) Medical Sciences, Liver Cell Biology, Gastroenterology, Laboratory of Molecullar and Cellular Therapy, and Translational Liver Cell Biology

Subjects
chronical alcohol abuse, MIRFIB, NAFLD, hepatology, viral liver disease, liver fibrosis
Published
2019

39. The PDGFR-beta containing PRTA-score is a novel non-invasive diagnostic algorithm for significant liver fibrosis in patients with viral, alcoholic, and metabolic liver disease

Author

Lambrecht, Joeri, Verhulst, Stefaan, Mannaerts, Inge, Sowa, Jan-Peter, Jan Best, Canbay, Ali, Reynaert, Hendrik, Grunsven, Leo A., Faculty of Medicine and Pharmacy, Basic (bio-) Medical Sciences, Liver Cell Biology, Gastroenterology, Laboratory of Molecullar and Cellular Therapy, and Translational Liver Cell Biology

Subjects
PRTA-score, metabolic liver disease, hepatology, viral liver disease, liver disease, PDGFR-beta, liver fibrosis, alcoholic liver disease
Published
2019

50. New Concepts in Liver Regeneration Mechanisms in Human Severe Alcoholic Steatohepatitis

Author

Lejeune, Adrienne, Starkel, Peter, Louvet, Alexandre, Hittelet, Axel, Bazille, Celine, Bastens, Boris, Orient, Hans, Lasser, Luc I., Dekoninck, Xavier, Dastis, Sergio Negrin, Delwaide, Jean, Anja, Geerts, De Galocsy, Chantal, Putzeys, Virginie, Langlet, Phillippe, Reynaert, Hendrik, Francque, Sven M., Komuta, Mina, Lanthier, Nicolas, Basic (bio-) Medical Sciences, Gastroenterology, Laboratory of Molecullar and Cellular Therapy, and Liver Cell Biology

Published
2018

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