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2. Global, regional, and national disease burden estimates of acute lower respiratory infections due to respiratory syncytial virus in children younger than 5 years in 2019: a systematic analysis

Author

Abram, Michael, Aerssens, Jeroen, Alafaci, Annette, Balmaseda, Angel, Bandeira, Teresa, Barr, Ian, Batinović, Ena, Beutels, Philippe, Bhiman, Jinal, Blyth, Christopher C, Bont, Louis, Bressler, Sara S, Cohen, Cheryl, Cohen, Rachel, Costa, Anna-Maria, Crow, Rowena, Daley, Andrew, Dang, Duc-Anh, Demont, Clarisse, Desnoyers, Christine, Díez-Domingo, Javier, Divarathna, Maduja, du Plessis, Mignon, Edgoose, Madeleine, Ferolla, Fausto Martín, Fischer, Thea K, Gebremedhin, Amanuel, Giaquinto, Carlo, Gillet, Yves, Hernandez, Roger, Horvat, Come, Javouhey, Etienne, Karseladze, Irakli, Kubale, John, Kumar, Rakesh, Lina, Bruno, Lucion, Florencia, MacGinty, Rae, Martinon-Torres, Federico, McMinn, Alissa, Meijer, Adam, Milić, Petra, Morel, Adrian, Mulholland, Kim, Mungun, Tuya, Murunga, Nickson, Newbern, Claire, Nicol, Mark P, Odoom, John Kofi, Openshaw, Peter, Ploin, Dominique, Polack, Fernando P, Pollard, Andrew J, Prasad, Namrata, Puig-Barberà, Joan, Reiche, Janine, Reyes, Noelia, Rizkalla, Bishoy, Satao, Shilpa, Shi, Ting, Sistla, Sujatha, Snape, Matthew, Song, Yanran, Soto, Giselle, Tavakoli, Forough, Toizumi, Michiko, Tsedenbal, Naranzul, van den Berge, Maarten, Vernhes, Charlotte, von Mollendorf, Claire, Walaza, Sibongile, Walker, Gregory, Li, You, Wang, Xin, Blau, Dianna M, Caballero, Mauricio T, Feikin, Daniel R, Gill, Christopher J, Madhi, Shabir A, Omer, Saad B, Simões, Eric A F, Campbell, Harry, Pariente, Ana Bermejo, Bardach, Darmaa, Bassat, Quique, Casalegno, Jean-Sebastien, Chakhunashvili, Giorgi, Crawford, Nigel, Danilenko, Daria, Do, Lien Anh Ha, Echavarria, Marcela, Gentile, Angela, Gordon, Aubree, Heikkinen, Terho, Huang, Q Sue, Jullien, Sophie, Krishnan, Anand, Lopez, Eduardo Luis, Markić, Joško, Mira-Iglesias, Ainara, Moore, Hannah C, Moyes, Jocelyn, Mwananyanda, Lawrence, Nokes, D James, Noordeen, Faseeha, Obodai, Evangeline, Palani, Nandhini, Romero, Candice, Salimi, Vahid, Satav, Ashish, Seo, Euri, Shchomak, Zakhar, Singleton, Rosalyn, Stolyarov, Kirill, Stoszek, Sonia K, von Gottberg, Anne, Wurzel, Danielle, Yoshida, Lay-Myint, Yung, Chee Fu, Zar, Heather J, and Nair, Harish

Published
2022
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4. Supplementary Materials for Early cortical GABAergic interneurons determine the projection patterns of L4 excitatory neurons

Author

Bragg-Gonzalo, Lorena, Aguilera, Alfonso, González-Arias, Candela, De León Reyes, Noelia S., Sánchez-Cruz, Alonso, Carballeira, Paula, Leroy, Felix, Perea, Gertrudis, Nieto, Marta, Bragg-Gonzalo, Lorena, Aguilera, Alfonso, González-Arias, Candela, De León Reyes, Noelia S., Sánchez-Cruz, Alonso, Carballeira, Paula, Leroy, Felix, Perea, Gertrudis, and Nieto, Marta

Published
2024

5. Early cortical GABAergic interneurons determine the projection patterns of L4 excitatory neurons

Author

European Commission, Fundación la Caixa, Ministerio de Ciencia e Innovación (España), Ministerio de Ciencia, Innovación y Universidades (España), Agencia Estatal de Investigación (España), Fundació La Marató de TV3, Comunidad de Madrid, European Research Council, Generalitat Valenciana, Bragg-Gonzalo, Lorena, Aguilera, Alfonso, González-Arias, Candela, De León Reyes, Noelia S., Sánchez-Cruz, Alonso, Carballeira, Paula, Leroy, Felix, Perea, Gertrudis, Nieto, Marta, European Commission, Fundación la Caixa, Ministerio de Ciencia e Innovación (España), Ministerio de Ciencia, Innovación y Universidades (España), Agencia Estatal de Investigación (España), Fundació La Marató de TV3, Comunidad de Madrid, European Research Council, Generalitat Valenciana, Bragg-Gonzalo, Lorena, Aguilera, Alfonso, González-Arias, Candela, De León Reyes, Noelia S., Sánchez-Cruz, Alonso, Carballeira, Paula, Leroy, Felix, Perea, Gertrudis, and Nieto, Marta

Abstract

During cerebral cortex development, excitatory pyramidal neurons (PNs) establish specific projection patterns while receiving inputs from GABAergic inhibitory interneurons (INs). Whether these inhibitory inputs can shape PNs' projection patterns is, however, unknown. While layer 4 (L4) PNs of the primary somatosensory (S1) cortex are all born as long-range callosal projection neurons (CPNs), most of them acquire local connectivity upon activity-dependent elimination of their interhemispheric axons during postnatal development. Here, we demonstrate that precise developmental regulation of inhibition is key for the retraction of S1L4 PNs' callosal projections. Ablation of somatostatin INs leads to premature inhibition from parvalbumin INs onto S1L4 PNs and prevents them from acquiring their barrel-restricted local connectivity pattern. As a result, adult S1L4 PNs retain interhemispheric projections responding to tactile stimuli, and the mice lose whisker-based texture discrimination. Overall, we show that temporally ordered IN activity during development is key to shaping local ipsilateral S1L4 PNs' projection pattern, which is required for fine somatosensory processing.

Published
2024

6. Global burden of respiratory infections associated with seasonal influenza in children under 5 years in 2018: a systematic review and modelling study

Author

Nair, Harish, Campbell, Harry, Wang, Xin, Li, You, Chung, Alexandria, Rahi, Manveer, Abbas, Qalab, Ali, Asad, Bhutta, Zulfiqar A, Saeed, Bushra, Soofi, Sajid B, Yousafzai, Mohammad Tahir, Zaidi, Anita K, Amu, Alberta, Awini, Elizabeth, Azziz-Baumgartner, Eduardo, Baggett, Henry C, Chaves, Sandra S, Shang, Nong, Schrag, Stephanie J, Widdowson, Marc-Alain, Tempia, Stefano, Bassat, Quique, Lanaspa, Miguel, Acácio, Sozinho, Brooks, W Abdullah, Driscoll, Amanda, Knoll, Maria Deloria, O'Brien, Katherine L, Prosperi, Christine, Baqui, Abdullah H, Mullany, Luke, Byass, Peter, Cohen, Cheryl, von Gottberg, Anne, Hellferscee, Orienka, Treurnicht, Florette K, Walaza, Sibongile, Goswami, Doli, Rahman, Mustafizur, Connor, Nicholas E, El Arifeen, Shams, Echavarria, Marcela, Marcone, Débora N, Reyes, Noelia, Gutierrez, Andrea, Rodriguez, Ivan, Lopez, Olga, Ortiz, David, Gonzalez, Nathaly, Gentile, Angela, del Valle Juarez, Maria, Gordon, Aubree, Cutland, Clare, Groome, Michelle, Madhi, Shabir A, Nunes, Marta C, Nzenze, Susan, Heikkinen, Terho, Hirve, Siddhivinayak, Juvekar, Sanjay, Halasa, Natasha, Jara, Jorge H, Bernart, Chris, Katz, Mark A, Gofer, Ilan, Avni, Yonat Shemer, Khuri-Bulos, Najwa, Faori, Samir, Shehabi, Asem, Krishnan, Anand, Kumar, Rakesh, Amarchand, Ritvik, Contreras, Carmen L, de Leon, Oscar, Lopez, Maria R, McCracken, John P, Maldonado, Herberth, Samayoa, Antonio P, Gomez, Ana B, Lucero, Marilla G, Nillos, Leilani T, Lupisan, Socorro P, Nohynek, Hanna, Mira-Iglesias, Ainara, Puig-Barberà, Joan, Díez-Domingo, Javier, Gessner, Bradford D, Njanpop-Lafourcade, Berthe-Marie, Moïsi, Jennifer C, Tall, Haoua, Munywoki, Patrick K, Ngama, Mwanjuma, Nokes, D James, Omer, Saad B, Clark, Dayna R, Ourohiré, Millogo, Ali, Sié, Pascal, Zabré, Cheik, Bagagnan H, Caballero, Mauricio T, Libster, Romina, Polack, Fernando P, Rasmussen, Zeba A, Thomas, Elizabeth D, Baker, Julia M, Rath, Barbara A, Obermeier, Patrick E, Hassanuzzaman, MD., Islam, Maksuda, Islam, Mohammad S, Saha, Samir K, Panigrahi, Pinaki, Bose, Anuradha, Isaac, Rita, Murdoch, David, Nanda, Pritish, Qazi, Shamim A, Hessong, Danielle, Simőes, Eric AF, Sotomayor, Viviana, Thamthitiwat, Somsak, Chittaganpitch, Malinee, Dawood, Halima, Kyobutungi, Catherine, Wamukoya, Marylene, Ziraba, Abdhalah K, Yoshida, Lay-Myint, Yoshihara, Keisuke, Dand, Duc-Anh, Le, Minh-Nhat, Nicol, Mark P, Zar, Heather J, Broor, Shobha, Chadha, Mandeep, Madrid, Lola, Gresh, Lionel, Balmaseda, Angel, Kuan, Guillermina, Wairagkar, Niteen, Tapia, Milagritos D, Knobler, Stacey L, Barahona, Alfredo, Ferguson, Ericka, Schweiger, Brunhilde, Abdullah Brooks, W, Fasce, Rodrigo A, and Simões, Eric AF

Published
2020
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7. Torque Teno Virus (TTV) in Renal Transplant Recipients: Species Diversity and Variability.

Author

Reyes, Noelia Soledad, Spezia, Pietro Giorgio, Jara, Raquel, Filippini, Fabio, Boccia, Natalia, García, Gonzalo, Hermida, Eliana, Poletta, Fernando Adrian, Pistello, Mauro, Laham, Gustavo, Maggi, Fabrizio, and Echavarria, Marcela

Subjects
*TORQUE teno virus, *KIDNEY transplantation, *NUMBERS of species, *VIRAL load, *SPECIES diversity
Abstract

Torque Teno Virus (TTV) is a nonpathogenic and ubiquitous ssDNA virus, a member of the Anelloviridae family. TTV has been postulated as a biomarker in transplant patients. This study aimed to determine the TTV species diversity and variability in renal transplant recipients and to associate species diversity with the corresponding TTV viral load. From 27 recipients, 30 plasma samples were selected. Viral load was determined using two real-time PCR assays, followed by RCA-NGS and ORF1 phylogenetic analysis. The TTV diversity was determined in all samples. Variability was determined in three patients with two sequential samples (pre- and post-transplantation). Most of the samples presented multiple TTV species, up to 15 different species were detected. In the pre-transplant samples (n = 12), the most prevalent species were TTV3 (75%) and TTV13 (75%), and the median number of species per sample was 5 (IQR: 4–7.5). TTV3 was also the most prevalent (56%) in the post-transplant samples (n = 18), and the median number of species was 2 (IQR: 1.8–5.5). No significant correlation between the number of species and viral load was found. The number and type of TTV species showed total variability over time. We report high TTV species diversity in Argentinian recipients, especially in pre-transplant period, with total intra-host variability. However, we found no significant correlation between this high diversity and TTV viral load. [ABSTRACT FROM AUTHOR]

Published
2024
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8. Saliva screening of health care workers for SARS-CoV-2 detection

Author

Echavarria, Marcela, primary, Reyes, Noelia S., additional, Rodriguez, Pamela E., additional, Ricarte, Carmen, additional, Ypas, Martin, additional, Seoane, Alejandro, additional, Querci, Marcia, additional, Brizio, Marianela, additional, Stryjewski, Martin E., additional, and Carballal, Guadalupe, additional

Published
2022
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9. P8.010: The Association of Torque Teno Viral (TTV) Load With Acute Rejection and Viral Infections in the First-Year Post Renal Transplantation

Author

Boccia, Natalia, primary, Reyes, Noelia S., additional, Laham, Gustavo, additional, Garcia, Gonzalo, additional, Ricarte, Carmen, additional, Jara, Raquel, additional, Hermida, Eliana, additional, Pujol, Gervasio Soler, additional, Diaz, Carlos, additional, Caraballal, G., additional, and Echavarria, Marcela, additional

Published
2022
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10. Suicide in the national police corps (CNP). review of the mental health promotion plan and prevention of suicidal behaviour in the CNP

Author

Pérez Reyes, Noelia and Romero Carrasco, Esperanza Maria

Subjects
suicidi, police, prevention, Grau en Psicologia, Bachelor's Degree in Psychology, prevenció, salut mental, Grado en Psicología, suicide, mental health, policia
Abstract

Treball Final de Grau en Psicologia. Codi: PS1048. Curs: 2021/2022 Aquest Treball de Final de Grau mostra un anàlisi de dades sobre el suïcidi en el Cos Nacional de Policia (CNP), així com l’estudi sobre el Pla de Promoció de la Salut Mental i Prevenció de la Conducta Suïcida en la Policia Nacional (2020) i l’abast de la seua aplicació. Per l’anàlisi de dades s’han consultat tant bases oficials nacionals com informacions aconseguides a través d’altres organitzacions, com sindicats i mitjans de comunicació. Pel que fa a l’abast de l’aplicació de l’esmentat Pla, la informació s’ha obtingut a través de la Direcció General de Policia (DGP) i d’entrevistes, a títol personal, amb agents del CNP i per telefonades a diferents comissaries del territori espanyol. S’han realitzat dues tècniques d’investigació: la revisió bibliogràfica des de l’any 2000 fins el 2021 i les entrevistes informals a agents del CNP. Aquest estudi té dos objectius principals: el primer, conèixer la incidència del suïcidi en el CNP així com el comportament de diferents variables que afecten a les conductes suïcides en els membres del CNP, realitzant anàlogament una comparació amb la incidència en la Guàrdia Civil i en la població en general. En segon lloc, revisar l’esmentat Pla i l’aplicació (des de la seua entrada en vigor) de les mesures que en ell es plantegen. Els resultats mostren que el nombre de suïcidis en el CNP és semblant a l’ocorregut en la Guàrdia Civil i superior als produïts entre la població general, amb la diferència de l’ús de les armes com a medi d’execució. Pel que fa al Pla de Promoció de la Salut Mental i Prevenció de la Conducta Suïcida en la Policia Nacional, s’aprecia que es troba en un estadi inicial d’aplicació amb mancances de medis molt importants, especialment pel que fa a la falta de professionals de la Psicologia. This TFG Project shows an analysis of data on suicide in the Spanish National Police (CNP) as well as the study of the Plan for the Promotion of Mental Health and Prevention of Suicidal Behaviour in the national Police (2020) and the extent of its application. For data analysis, both national official databases and information collected by other organizations, such as unions and media, have been consulted. Regarding the scope of the application of the aforementioned Plan, the information has been obtained through the DGP (DirectorateGeneral of the Police) and from interviews with CNP agents in a personal capacity and by calls to different police stations in Spanish territory. Two research techniques have been used: the bibliographic review from 2000 to 2021 and informal interviews with CNP agents. This study has two main objectives: first, we wanted to know the incidence of suicide in the CNP as well as the behaviour of different variables that affect suicidal tendencies in members of the CNP, making a comparison with the incidence in the Civil Guard and in the general population too. Secondly, to review the Plan and the application (from its implementation) of the measures proposed in it. The results show that the number of suicides in the CNP are similar to those that occur in the Civil Guard and higher than those produced in the general population, with the difference being the use of weapons as means of execution. As for the Plan for the Promotion of Mental Health and Prevention of Suicidal Behaviour in the national Police, it can be seen that it is in a very early stage of application, with a significant lack of resources, especially with regard to the lack of psychology professionals.

Published
2022

11. SHEDDING OF INFECTIOUS SARS-COV-2 IN TWO ASYMPTOMATIC CHILDREN.

Author

REYES, NOELIA S., RODRIGUEZ, PAMELA E., RICARTE, CARMEN, ECHEGOYEN, NATALIA, VIEGAS, MARIANA, VARESE, AUGUSTO, CEBALLOS, ANA, STRYJEWSKI, MARTÍN E., and ECHAVARRIA, MARCELA

Abstract

Copyright of Medicina (Buenos Aires) is the property of Medicina (Buenos Aires) and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Published
2023

12. Global, regional, and national disease burden estimates of acute lower respiratory infections due to respiratory syncytial virus in children younger than 5 years in 2019: a systematic analysis

Author

Li, You, primary, Wang, Xin, additional, Blau, Dianna M, additional, Caballero, Mauricio T, additional, Feikin, Daniel R, additional, Gill, Christopher J, additional, Madhi, Shabir A, additional, Omer, Saad B, additional, Simões, Eric A F, additional, Campbell, Harry, additional, Pariente, Ana Bermejo, additional, Bardach, Darmaa, additional, Bassat, Quique, additional, Casalegno, Jean-Sebastien, additional, Chakhunashvili, Giorgi, additional, Crawford, Nigel, additional, Danilenko, Daria, additional, Do, Lien Anh Ha, additional, Echavarria, Marcela, additional, Gentile, Angela, additional, Gordon, Aubree, additional, Heikkinen, Terho, additional, Huang, Q Sue, additional, Jullien, Sophie, additional, Krishnan, Anand, additional, Lopez, Eduardo Luis, additional, Markić, Joško, additional, Mira-Iglesias, Ainara, additional, Moore, Hannah C, additional, Moyes, Jocelyn, additional, Mwananyanda, Lawrence, additional, Nokes, D James, additional, Noordeen, Faseeha, additional, Obodai, Evangeline, additional, Palani, Nandhini, additional, Romero, Candice, additional, Salimi, Vahid, additional, Satav, Ashish, additional, Seo, Euri, additional, Shchomak, Zakhar, additional, Singleton, Rosalyn, additional, Stolyarov, Kirill, additional, Stoszek, Sonia K, additional, von Gottberg, Anne, additional, Wurzel, Danielle, additional, Yoshida, Lay-Myint, additional, Yung, Chee Fu, additional, Zar, Heather J, additional, Nair, Harish, additional, Abram, Michael, additional, Aerssens, Jeroen, additional, Alafaci, Annette, additional, Balmaseda, Angel, additional, Bandeira, Teresa, additional, Barr, Ian, additional, Batinović, Ena, additional, Beutels, Philippe, additional, Bhiman, Jinal, additional, Blyth, Christopher C, additional, Bont, Louis, additional, Bressler, Sara S, additional, Cohen, Cheryl, additional, Cohen, Rachel, additional, Costa, Anna-Maria, additional, Crow, Rowena, additional, Daley, Andrew, additional, Dang, Duc-Anh, additional, Demont, Clarisse, additional, Desnoyers, Christine, additional, Díez-Domingo, Javier, additional, Divarathna, Maduja, additional, du Plessis, Mignon, additional, Edgoose, Madeleine, additional, Ferolla, Fausto Martín, additional, Fischer, Thea K, additional, Gebremedhin, Amanuel, additional, Giaquinto, Carlo, additional, Gillet, Yves, additional, Hernandez, Roger, additional, Horvat, Come, additional, Javouhey, Etienne, additional, Karseladze, Irakli, additional, Kubale, John, additional, Kumar, Rakesh, additional, Lina, Bruno, additional, Lucion, Florencia, additional, MacGinty, Rae, additional, Martinon-Torres, Federico, additional, McMinn, Alissa, additional, Meijer, Adam, additional, Milić, Petra, additional, Morel, Adrian, additional, Mulholland, Kim, additional, Mungun, Tuya, additional, Murunga, Nickson, additional, Newbern, Claire, additional, Nicol, Mark P, additional, Odoom, John Kofi, additional, Openshaw, Peter, additional, Ploin, Dominique, additional, Polack, Fernando P, additional, Pollard, Andrew J, additional, Prasad, Namrata, additional, Puig-Barberà, Joan, additional, Reiche, Janine, additional, Reyes, Noelia, additional, Rizkalla, Bishoy, additional, Satao, Shilpa, additional, Shi, Ting, additional, Sistla, Sujatha, additional, Snape, Matthew, additional, Song, Yanran, additional, Soto, Giselle, additional, Tavakoli, Forough, additional, Toizumi, Michiko, additional, Tsedenbal, Naranzul, additional, van den Berge, Maarten, additional, Vernhes, Charlotte, additional, von Mollendorf, Claire, additional, Walaza, Sibongile, additional, and Walker, Gregory, additional

Published
2022
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14. Whole-exome sequencing reveals ZNF408 as a new gene associated with autosomal recessive retinitis pigmentosa with vitreal alterations

Author

Avila-Fernandez, Almudena, Perez-Carro, Raquel, Corton, Marta, Lopez-Molina, Maria Isabel, Campello, Laura, Garanto, Alejandro, Fernandez-Sanchez, Laura, Duijkers, Lonneke, Lopez-Martinez, Miguel Angel, Riveiro-Alvarez, Rosa, Da Silva, Luciana Rodrigues Jacy, Sanchez-Alcudia, Rocío, Martin-Garrido, Esther, Reyes, Noelia, Garcia-Garcia, Francisco, Dopazo, Joaquin, Garcia-Sandoval, Blanca, Collin, Rob W.J., Cuenca, Nicolas, and Ayuso, Carmen

Published
2015
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16. Development and plasticity of the corpus callosum

Author

León-Reyes, Noelia S. de, Bragg-Gonzalo, Lorena, Nieto, Marta, European Commission, Ministerio de Economía y Competitividad (España), Ministerio de Ciencia, Innovación y Universidades (España), and Agencia Estatal de Investigación (España)

Subjects
Axonal guidance and plasticity, Corpus callosum, Agenesis, Cortex, Callosal projecting neurons, Development, Interhemispheric
Abstract

© 2020. Published by The Company of Biologists Ltd The corpus callosum (CC) connects the cerebral hemispheres and is the major mammalian commissural tract. It facilitates bilateral sensory integration and higher cognitive functions, and is often affected in neurodevelopmental diseases. Here, we review the mechanisms that contribute to the development of CC circuits in animal models and humans. These species comparisons reveal several commonalities. First, there is an early period of massive axonal projection. Second, there is a postnatal temporal window, varying between species, in which early callosal projections are selectively refined. Third, sensory-derived activity influences axonal refinement. We also discuss how defects in CC formation can lead to mild or severe CC congenital malformations. his work was funded by grants from ERA-Net Neuron, the European Union and the Ministerio de Economı́a, Industria y Competitividad de España (ERA-Net Neuron/PCIN-2015-176-C02-02); from the Ministerio de Ciencia, Innovación y Universidades/Agencia Estatal de Investigación/Fondo Europeo de Desarrollo Regional, European Union (SAF2017-83117-R and RED2018-102553T); and from the European Union, FLAG-ERA-Human Brain Project, Ministerio de Ciencia, Innovación y Universidades/Agencia Estatal de Investigación/Fondo Europeo de Desarrollo Regional, European Union (PCI2019- 111872-2).

Published
2020

17. Development and plasticity of the corpus callosum

Author

European Commission, Ministerio de Economía y Competitividad (España), Ministerio de Ciencia, Innovación y Universidades (España), Agencia Estatal de Investigación (España), León-Reyes, Noelia S. de, Bragg-Gonzalo, Lorena, Nieto, Marta, European Commission, Ministerio de Economía y Competitividad (España), Ministerio de Ciencia, Innovación y Universidades (España), Agencia Estatal de Investigación (España), León-Reyes, Noelia S. de, Bragg-Gonzalo, Lorena, and Nieto, Marta

Abstract

The corpus callosum (CC) connects the cerebral hemispheres and is the major mammalian commissural tract. It facilitates bilateral sensory integration and higher cognitive functions, and is often affected in neurodevelopmental diseases. Here, we review the mechanisms that contribute to the development of CC circuits in animal models and humans. These species comparisons reveal several commonalities. First, there is an early period of massive axonal projection. Second, there is a postnatal temporal window, varying between species, in which early callosal projections are selectively refined. Third, sensory-derived activity influences axonal refinement. We also discuss how defects in CC formation can lead to mild or severe CC congenital malformations.

Published
2020

18. Self‐collected saliva for SARS‐CoV‐2 detection: A prospective study in the emergency room

Author

Echavarria, Marcela, primary, Reyes, Noelia S., additional, Rodriguez, Pamela E., additional, Ypas, Martin, additional, Ricarte, Carmen, additional, Rodriguez, María P., additional, Perez, Matias G., additional, Seoane, Alejandro, additional, Martinez, Alfredo, additional, Videla, Cristina, additional, Stryjewski, Martin E., additional, and Carballal, Guadalupe, additional

Published
2021
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23. Direct costs and clinical impact of adenovirus genotype 8 conjunctivitis outbreak in a neonatology unit

Author

Angueyra, María Florencia, primary, Marcone, Débora Natalia, additional, Escarrá, Florencia, additional, Reyes, Noelia Soledad, additional, Rubies, Yamile, additional, Albas, Delcys, additional, Rodríguez, Pamela Elizabeth, additional, Vidaurreta, Santiago, additional, Carballal, Guadalupe, additional, and Echavarria, Marcela, additional

Published
2020
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24. Global burden of respiratory infections associated with seasonal influenza in children under 5 years in 2018: a systematic review and modelling study

Author

Wang, Xin, primary, Li, You, additional, O'Brien, Katherine L, additional, Madhi, Shabir A, additional, Widdowson, Marc-Alain, additional, Byass, Peter, additional, Omer, Saad B, additional, Abbas, Qalab, additional, Ali, Asad, additional, Amu, Alberta, additional, Azziz-Baumgartner, Eduardo, additional, Bassat, Quique, additional, Abdullah Brooks, W, additional, Chaves, Sandra S, additional, Chung, Alexandria, additional, Cohen, Cheryl, additional, Echavarria, Marcela, additional, Fasce, Rodrigo A, additional, Gentile, Angela, additional, Gordon, Aubree, additional, Groome, Michelle, additional, Heikkinen, Terho, additional, Hirve, Siddhivinayak, additional, Jara, Jorge H, additional, Katz, Mark A, additional, Khuri-Bulos, Najwa, additional, Krishnan, Anand, additional, de Leon, Oscar, additional, Lucero, Marilla G, additional, McCracken, John P, additional, Mira-Iglesias, Ainara, additional, Moïsi, Jennifer C, additional, Munywoki, Patrick K, additional, Ourohiré, Millogo, additional, Polack, Fernando P, additional, Rahi, Manveer, additional, Rasmussen, Zeba A, additional, Rath, Barbara A, additional, Saha, Samir K, additional, Simões, Eric AF, additional, Sotomayor, Viviana, additional, Thamthitiwat, Somsak, additional, Treurnicht, Florette K, additional, Wamukoya, Marylene, additional, Yoshida, Lay-Myint, additional, Zar, Heather J, additional, Campbell, Harry, additional, Nair, Harish, additional, Wang, Xin, additional, Bhutta, Zulfiqar A, additional, Saeed, Bushra, additional, Soofi, Sajid B, additional, Yousafzai, Mohammad Tahir, additional, Zaidi, Anita K, additional, Awini, Elizabeth, additional, Baggett, Henry C, additional, Shang, Nong, additional, Schrag, Stephanie J, additional, Tempia, Stefano, additional, Lanaspa, Miguel, additional, Acácio, Sozinho, additional, Brooks, W Abdullah, additional, Driscoll, Amanda, additional, Knoll, Maria Deloria, additional, Prosperi, Christine, additional, Baqui, Abdullah H, additional, Mullany, Luke, additional, von Gottberg, Anne, additional, Hellferscee, Orienka, additional, Walaza, Sibongile, additional, Goswami, Doli, additional, Rahman, Mustafizur, additional, Connor, Nicholas E, additional, El Arifeen, Shams, additional, Marcone, Débora N, additional, Reyes, Noelia, additional, Gutierrez, Andrea, additional, Rodriguez, Ivan, additional, Lopez, Olga, additional, Ortiz, David, additional, Gonzalez, Nathaly, additional, del Valle Juarez, Maria, additional, Cutland, Clare, additional, Nunes, Marta C, additional, Nzenze, Susan, additional, Juvekar, Sanjay, additional, Halasa, Natasha, additional, Bernart, Chris, additional, Gofer, Ilan, additional, Avni, Yonat Shemer, additional, Faori, Samir, additional, Shehabi, Asem, additional, Kumar, Rakesh, additional, Amarchand, Ritvik, additional, Contreras, Carmen L, additional, Lopez, Maria R, additional, Maldonado, Herberth, additional, Samayoa, Antonio P, additional, Gomez, Ana B, additional, Nillos, Leilani T, additional, Lupisan, Socorro P, additional, Nohynek, Hanna, additional, Puig-Barberà, Joan, additional, Díez-Domingo, Javier, additional, Gessner, Bradford D, additional, Njanpop-Lafourcade, Berthe-Marie, additional, Tall, Haoua, additional, Ngama, Mwanjuma, additional, Nokes, D James, additional, Clark, Dayna R, additional, Ali, Sié, additional, Pascal, Zabré, additional, Cheik, Bagagnan H, additional, Caballero, Mauricio T, additional, Libster, Romina, additional, Thomas, Elizabeth D, additional, Baker, Julia M, additional, Obermeier, Patrick E, additional, Hassanuzzaman, MD., additional, Islam, Maksuda, additional, Islam, Mohammad S, additional, Panigrahi, Pinaki, additional, Bose, Anuradha, additional, Isaac, Rita, additional, Murdoch, David, additional, Nanda, Pritish, additional, Qazi, Shamim A, additional, Hessong, Danielle, additional, Simőes, Eric AF, additional, Chittaganpitch, Malinee, additional, Dawood, Halima, additional, Kyobutungi, Catherine, additional, Ziraba, Abdhalah K, additional, Yoshihara, Keisuke, additional, Dand, Duc-Anh, additional, Le, Minh-Nhat, additional, Nicol, Mark P, additional, Broor, Shobha, additional, Chadha, Mandeep, additional, Madrid, Lola, additional, Gresh, Lionel, additional, Balmaseda, Angel, additional, Kuan, Guillermina, additional, Wairagkar, Niteen, additional, Tapia, Milagritos D, additional, Knobler, Stacey L, additional, Barahona, Alfredo, additional, Ferguson, Ericka, additional, and Schweiger, Brunhilde, additional

Published
2020
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25. Plan de negocios para la prestación de servicios no calificados mediante una plataforma virtual mandaditos.com

Author

Alvarado Alejos, Deyven Manuel, Asencio Reyes, Noelia Jacqueline, Cruz Condormango, Alan Gabriel, Fayad Sam Niego, Yebel Angel, Sánchez Placencia, Josecarlos Edilberto, and Morris Abarca, Eddy

Subjects
Comercio electrónico, Aplicaciones de computadoras, Trabajo a domicilio, Servicios al cliente, Planificación de la empresa, Estudios de viabilidad, Sitios web, purl.org/pe-repo/ocde/ford#5.02.04 [https]
Abstract

Hoy en día los servicios a domicilio no son algo nuevo y menos son exclusivos de las comidas rápidas. La tecnología acompañada con la falta de tiempo en la vida de las personas, está permitiendo que se demanden productos y servicios desde cualquier plataforma conectada al internet. Es por esta razón, que el mercado se viene adaptando cada vez más a las nuevas oportunidades de negocio con el fin de satisfacer las necesidades reales de los consumidores. El presente plan de negocio tiene como principal objetivo determinar la viabilidad comercial, operativa y económica para la implementación de la plataforma web mandaditos.com donde puedes contratar servicios no calificados a domicilio. Se ofrece servicios de limpieza del hogar, paseo de perros, reforzamiento escolar y lavado de carros realizado por estudiantes universitarios en la ciudad de Trujillo para viviendas del segmento socioeconómico AB, en donde se asegura la calidad y confianza de los servicios brindados. La idea de negocio nace para mitigar uno de los principales problemas que afrontan los universitarios, que es la deserción estudiantil, ya que diversos estudios indican que los universitarios se retiran de la universidad principalmente por una falta de orientación vocacional y también por falta de recursos económicos.

Published
2019

26. Role of rhinovirus C in apparently life-threatening events in infants, Spain

Author

Calvo, Cristina, Garcia, M. Luz, Pozo, Francisco, Reyes, Noelia, Perez-Brena, Pilar, and Casas, Inmaculada

Subjects
Asthma in children -- Development and progression, Infection -- Development and progression, Infants
Abstract

Human rhinovirus (HRV) is 1 of the most common agents associated with upper and lower respiratory tract infections in children and infants (1) and is a major trigger of asthma [...]

Published
2009
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27. The role of PKD1 in brain injury: ROS detoxification and neuroprotection

Author

Pose-Utrilla, Julia, García-Guerra, Lucía, Puerto, Ana del, Martín-Muñóz, A., Jurado-Arjona, Jerónimo, León-Reyes, Noelia S. de, Gamir-Morralla, Andrea, Sebastián-Serrano, Álvaro, Fielitz, Jens, Ferrer, Isidro, Hernández Álvarez, Félix, Campanero, Miguel R., and Iglesias, Teresa

Subjects
Stroke, Oxidative stress, Neuronal death, PKD1, Excitotoxicity
Abstract

Resumen del trabajo presentado al 1st PhD Research Symposium in Health Sciences and Biomedicine, celebrado en la Universidad Autónoma de Madrid el 18 de mayo de 2018.

Published
2018

28. Neuroprotective role of PKD1 against ischemic and kainic acid-induced brain injury

Author

García-Guerra, Lucía, Pose-Utrilla, Julia, Puerto, Ana del, Martín-Muñóz, A., Jurado-Arjona, Jerónimo, León-Reyes, Noelia S. de, Gamir-Morralla, Andrea, Sebastián-Serrano, Álvaro, Fielitz, Jens, Ferrer, Isidro, Hernández, Félix, Ávila, Jesús, Campanero, Miguel R., and Iglesias, Teresa

Abstract

Trabajo presentado en el Second Spanish Molecular Imaging Network (SMIN) Meeting, celebrado en Madrid (España) el 26 de febrero de 2018.

Published
2018

30. Mechanisms of PKD inactivation in excitotoxic brain damage: How PKD activity protects neurons from death

Author

García-Guerra, Lucía, Pose-Utrilla, Julia, León-Reyes, Noelia S. de, Jurado-Arjona, Jerónimo, Martín, Abraham, Puerto, Ana del, Gamir-Morralla, Andrea, Sebastián-Serrano, Álvaro, Fielitz, Jens, Ireson, Christofer, Pérez-Álvarez, María José, Ferrer, Isidro, Hernández Álvarez, Félix, Ávila, Jesús, Lasa, Marina, Campanero, Miguel R., and Iglesias, Teresa

Abstract

Trabajo presentado al 17 National Congress of the Spanish Society of Neuroscience (SENC), celebrado en Alicante (España) del 27 al 30 de septiembre de 2017.

Published
2017

31. PKD is regulated in excitotoxic conditions

Author

García-Guerra, Lucía, Pose-Utrilla, Julia, León-Reyes, Noelia S. de, Martín, Abraham, Puerto, Ana del, Gamir-Morralla, Andrea, Ireson, Christofer, and Iglesias, Teresa

Abstract

Trabajo presentado al 1st Spanish Molecular Imaging Network (SMIN) Meeting, celebrado en Madrid el 30 de enero dew 2017.

Published
2017

32. Author Correction: Excitotoxic inactivation of constitutive oxidative stress detoxification pathway in neurons can be rescued by PKD1

Author

Pose-Utrilla, Julia, primary, García-Guerra, Lucía, additional, Del Puerto, Ana, additional, Martín, Abraham, additional, Jurado-Arjona, Jerónimo, additional, De León-Reyes, Noelia S., additional, Gamir-Morralla, Andrea, additional, Sebastián-Serrano, Álvaro, additional, García-Gallo, Mónica, additional, Kremer, Leonor, additional, Fielitz, Jens, additional, Ireson, Christofer, additional, Pérez-Álvarez, Mª José, additional, Ferrer, Isidro, additional, Hernández, Félix, additional, Ávila, Jesús, additional, Lasa, Marina, additional, Campanero, Miguel R., additional, and Iglesias, Teresa, additional

Published
2018
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33. Excitotoxic inactivation of constitutive oxidative stress detoxification pathway in neurons can be rescued by PKD1

Author

Pose-Utrilla, Julia, primary, García-Guerra, Lucía, additional, Del Puerto, Ana, additional, Martín, Abraham, additional, Jurado-Arjona, Jerónimo, additional, De León-Reyes, Noelia S., additional, Gamir-Morralla, Andrea, additional, Sebastián-Serrano, Álvaro, additional, García-Gallo, Mónica, additional, Kremer, Leonor, additional, Fielitz, Jens, additional, Ireson, Christofer, additional, Pérez-Álvarez, Mª José, additional, Ferrer, Isidro, additional, Hernández, Félix, additional, Ávila, Jesús, additional, Lasa, Marina, additional, Campanero, Miguel R., additional, and Iglesias, Teresa, additional

Published
2017
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34. Excitotoxic inactivation of constitutive oxidative stress detoxification pathway in neurons can be rescued by PKD1

Author

Ministerio de Economía, Industria y Competitividad (España), Comunidad de Madrid, Instituto de Salud Carlos III, Centro Investigación Biomédica en Red Enfermedades Neurodegenerativas (España), Ministerio de Economía y Competitividad (España), European Commission, Consejo Superior de Investigaciones Científicas (España), Pose-Utrilla, Julia, García-Guerra, Lucía, Puerto, Ana del, Martín, Abraham, Jurado-Arjona, Jerónimo, León-Reyes, Noelia S. de, Gamir-Morralla, Andrea, Sebastián-Serrano, Álvaro, García-Gallo, Mónica, Kremer, Leonor, Fielitz, Jens, Ireson, Christofer, Pérez-Álvarez, María José, Ferrer, Isidro, Hernández Álvarez, Félix, Ávila, Jesús, Lasa, Marina, Campanero, Miguel R., Iglesias, Teresa, Ministerio de Economía, Industria y Competitividad (España), Comunidad de Madrid, Instituto de Salud Carlos III, Centro Investigación Biomédica en Red Enfermedades Neurodegenerativas (España), Ministerio de Economía y Competitividad (España), European Commission, Consejo Superior de Investigaciones Científicas (España), Pose-Utrilla, Julia, García-Guerra, Lucía, Puerto, Ana del, Martín, Abraham, Jurado-Arjona, Jerónimo, León-Reyes, Noelia S. de, Gamir-Morralla, Andrea, Sebastián-Serrano, Álvaro, García-Gallo, Mónica, Kremer, Leonor, Fielitz, Jens, Ireson, Christofer, Pérez-Álvarez, María José, Ferrer, Isidro, Hernández Álvarez, Félix, Ávila, Jesús, Lasa, Marina, Campanero, Miguel R., and Iglesias, Teresa

Abstract

Excitotoxicity, a critical process in neurodegeneration, induces oxidative stress and neuronal death through mechanisms largely unknown. Since oxidative stress activates protein kinase D1 (PKD1) in tumor cells, we investigated the effect of excitotoxicity on neuronal PKD1 activity. Unexpectedly, we find that excitotoxicity provokes an early inactivation of PKD1 through a dephosphorylation-dependent mechanism mediated by protein phosphatase-1 (PP1) and dual specificity phosphatase-1 (DUSP1). This step turns off the IKK/NF-¿B/SOD2 antioxidant pathway. Neuronal PKD1 inactivation by pharmacological inhibition or lentiviral silencing in vitro, or by genetic inactivation in neurons in vivo, strongly enhances excitotoxic neuronal death. In contrast, expression of an active dephosphorylation-resistant PKD1 mutant potentiates the IKK/NF-¿B/SOD2 oxidative stress detoxification pathway and confers neuroprotection from in vitro and in vivo excitotoxicity. Our results indicate that PKD1 inactivation underlies excitotoxicity-induced neuronal death and suggest that PKD1 inactivation may be critical for the accumulation of oxidation-induced neuronal damage during aging and in neurodegenerative disorders.

Published
2017

35. Direct costs and clinical impact of adenovirus genotype 8 conjunctivitis outbreak in a neonatology unit

Author

Angueyra, María Florencia, Marcone, Débora Natalia, Escarrá, Florencia, Reyes, Noelia Soledad, Rubies, Yamile, Albas, Delcys, Rodríguez, Pamela Elizabeth, Vidaurreta, Santiago, Carballal, Guadalupe, and Echavarria, Marcela

Abstract

AbstractObjective:To report a conjunctivitis outbreak in a neonatology intensive care unit (NICU) and determine the associated economic impact.Design:Prospective observational study.Setting:Centro de Educación Médica e Investigaciones Clínicas (CEMIC) University Hospital, a private, tertiary-care healthcare institution in Buenos Aires, Argentina.Participants:The study included 52 NICU neonates and 59 NICU-related healthcare workers (HCWs) from CEMIC hospital.Methods:Neonates and HCWs were swabbed for real-time polymerase chain reaction (PCR) testing, viral culture, and typing by sequencing. Infection control measures, structural and logistic changes were implemented. Billing records were analyzed to determine costs.Results:From January 30 to April 28, 2018, 52 neonates were hospitalized in the NICU. Among them, 14 of 52 (21%) had bilateral conjunctivitis with pseudomembranes. Symptomatic neonates and HCWs were HAdV-D8 positive. Ophthalmological symptoms had a median duration of 18 days (IQR, 13–24.5). PCR positivity and infectious range had a median duration of 18.5 days. As part of containment measures, the NICU and the high-risk pregnancy unit were closed to new patients. The NICU was divided into 2 areas for symptomatic and asymptomatic patients; a new room was assigned for the general nursery, and all deliveries from the high-risk pregnancy unit were redirected to other hospitals. The outbreak cost the hospital US$205,000: implementation of a new nursery room and extra salaries cost US$30,350 and estimated productivity loss during 1 month cost US$175,000.Conclusions:Laboratory diagnosis confirmed the cause of this outbreak as HAdV-D8. The immediate adoption and reinforcement of rigorous infection control measures limited the nosocomial viral spread. This outbreak represented a serious institutional problem, causing morbidity, significant economic loss, and absenteeism.

Published
2021
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38. Identification of the Photoreceptor Transcriptional Co-Repressor SAMD11 as Novel Cause of Autosomal Recessive Retinitis Pigmentosa

Author

Universidad de Alicante. Departamento de Fisiología, Genética y Microbiología, Corton, Marta, Ávila-Fernández, Almudena, Campello Blasco, Laura, Sánchez, Mónica, Benavides, Belén, López-Molina, María Isabel, Fernández-Sánchez, Laura, Sánchez-Alcudia, Rocío, Da Silva, Luciana Rodrigues Jacy, Reyes, Noelia, Martín-Garrido, Esther, Zurita, Olga, Fernández-San José, Patricia, Pérez-Carro, Raquel, García-García, Francisco, Dopazo, Joaquín, García-Sandoval, Blanca, Cuenca, Nicolás, Ayuso, Carmen, Universidad de Alicante. Departamento de Fisiología, Genética y Microbiología, Corton, Marta, Ávila-Fernández, Almudena, Campello Blasco, Laura, Sánchez, Mónica, Benavides, Belén, López-Molina, María Isabel, Fernández-Sánchez, Laura, Sánchez-Alcudia, Rocío, Da Silva, Luciana Rodrigues Jacy, Reyes, Noelia, Martín-Garrido, Esther, Zurita, Olga, Fernández-San José, Patricia, Pérez-Carro, Raquel, García-García, Francisco, Dopazo, Joaquín, García-Sandoval, Blanca, Cuenca, Nicolás, and Ayuso, Carmen

Abstract

Retinitis pigmentosa (RP), the most frequent form of inherited retinal dystrophy is characterized by progressive photoreceptor degeneration. Many genes have been implicated in RP development, but several others remain to be identified. Using a combination of homozygosity mapping, whole-exome and targeted next-generation sequencing, we found a novel homozygous nonsense mutation in SAMD11 in five individuals diagnosed with adult-onset RP from two unrelated consanguineous Spanish families. SAMD11 is ortholog to the mouse major retinal SAM domain (mr-s) protein that is implicated in CRX-mediated transcriptional regulation in the retina. Accordingly, protein-protein network analysis revealed a significant interaction of SAMD11 with CRX. Immunoblotting analysis confirmed strong expression of SAMD11 in human retina. Immunolocalization studies revealed SAMD11 was detected in the three nuclear layers of the human retina and interestingly differential expression between cone and rod photoreceptors was observed. Our study strongly implicates SAMD11 as novel cause of RP playing an important role in the pathogenesis of human degeneration of photoreceptors.

Published
2016

39. Whole-exome sequencing reveals ZNF408 as a new gene associated with autosomal recessive retinitis pigmentosa with vitreal alterations

Author

Universidad de Alicante. Departamento de Fisiología, Genética y Microbiología, Ávila-Fernández, Almudena, Pérez-Carro, Raquel, Corton, Marta, López-Molina, María Isabel, Campello Blasco, Laura, Garanto, Alejandro, Fernández-Sánchez, Laura, Duijkers, Lonneke, López-Martínez, Miguel Ángel, Riveiro-Álvarez, Rosa, Da Silva, Luciana Rodrigues Jacy, Sánchez-Alcudia, Rocío, Martín-Garrido, Esther, Reyes, Noelia, García-García, Francisco, Dopazo, Joaquín, García-Sandoval, Blanca, Collin, Rob W.J., Cuenca, Nicolás, Ayuso, Carmen, Universidad de Alicante. Departamento de Fisiología, Genética y Microbiología, Ávila-Fernández, Almudena, Pérez-Carro, Raquel, Corton, Marta, López-Molina, María Isabel, Campello Blasco, Laura, Garanto, Alejandro, Fernández-Sánchez, Laura, Duijkers, Lonneke, López-Martínez, Miguel Ángel, Riveiro-Álvarez, Rosa, Da Silva, Luciana Rodrigues Jacy, Sánchez-Alcudia, Rocío, Martín-Garrido, Esther, Reyes, Noelia, García-García, Francisco, Dopazo, Joaquín, García-Sandoval, Blanca, Collin, Rob W.J., Cuenca, Nicolás, and Ayuso, Carmen

Abstract

Retinitis pigmentosa (RP) is a group of progressive inherited retinal dystrophies that cause visual impairment as a result of photoreceptor cell death. RP is heterogeneous, both clinically and genetically making difficult to establish precise genotype–phenotype correlations. In a Spanish family with autosomal recessive RP (arRP), homozygosity mapping and whole-exome sequencing led to the identification of a homozygous mutation (c.358_359delGT; p.Ala122Leufs*2) in the ZNF408 gene. A screening performed in 217 additional unrelated families revealed another homozygous mutation (c.1621C>T; p.Arg541Cys) in an isolated RP case. ZNF408 encodes a transcription factor that harbors 10 predicted C2H2-type fingers thought to be implicated in DNA binding. To elucidate the ZNF408 role in the retina and the pathogenesis of these mutations we have performed different functional studies. By immunohistochemical analysis in healthy human retina, we identified that ZNF408 is expressed in both cone and rod photoreceptors, in a specific type of amacrine and ganglion cells, and in retinal blood vessels. ZNF408 revealed a cytoplasmic localization and a nuclear distribution in areas corresponding with the euchromatin fraction. Immunolocalization studies showed a partial mislocalization of the p.Arg541Cys mutant protein retaining part of the WT protein in the cytoplasm. Our study demonstrates that ZNF408, previously associated with Familial Exudative Vitreoretinopathy (FEVR), is a new gene causing arRP with vitreous condensations supporting the evidence that this protein plays additional functions into the human retina.

Published
2015

40. Alternative touristic route in Sevilla

Author

Medina Reyes, Noelia, Perales Gutiérrez, Juan José, and Universidad de Sevilla. Departamento de Filología Francesa

Abstract

Universidad de Sevilla. Grado en Turismo

Published
2013

43. Novel Flaviviruses Detected in Different Species of Mosquitoes in Spain

Author

Vázquez, Ana, Sánchez-Seco, María Paz, Palacios, Gustavo, Molero, Francisca, Reyes, Noelia, Ruiz, Santiago, Aranda, Carles, Marqués, Eduard, Escosa, Raul, Moreno, Juana, Figuerola, Jordi, Tenorio, Antonio, Vázquez, Ana, Sánchez-Seco, María Paz, Palacios, Gustavo, Molero, Francisca, Reyes, Noelia, Ruiz, Santiago, Aranda, Carles, Marqués, Eduard, Escosa, Raul, Moreno, Juana, Figuerola, Jordi, and Tenorio, Antonio

Abstract

We report the characterization of three novel flaviviruses isolated in Spain. Marisma Mosquito virus, a novel mosquito borne virus, was isolated from Ochlerotatus caspius mosquitoes; Spanish Ochlerotatus flavivirus and Spanish Culex flavivirus, two novel insect flaviviruses, were isolated from Oc. caspius and Culex pipiens, re- spectively. During this investigation, we designed a sensitive RT-nested polymerase chain reaction method that amplifies a 1019bp fragment of the flavivirus NS5 gene and could be directly used in clinical or environmental samples for flavivirus characterization and surveillance. Analysis of the sequence generated from that amplicon contains enough phylogenetic information for proper taxonomic studies. Moreover, the use of this tool allowed the detection of additional flavivirus DNA forms in Culex, Culiseta, and Ochlerotatus mosquitoes

Published
2012

45. Novel Flaviviruses Detected in Different Species of Mosquitoes in Spain

Author

Vázquez, Ana, primary, Sánchez-Seco, María-Paz, additional, Palacios, Gustavo, additional, Molero, Francisca, additional, Reyes, Noelia, additional, Ruiz, Santiago, additional, Aranda, Carles, additional, Marqués, Eduard, additional, Escosa, Raul, additional, Moreno, Juana, additional, Figuerola, Jordi, additional, and Tenorio, Antonio, additional

Published
2012
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48. La Risoteràpia com a tècnica per alleugerir el dolor en les Cures Pal·liatives Pediàtriques al final de la vida del nen oncològic

Author

Mora Fernández, Mateu, Tejero Reyes, Noelia, and Universitat de Lleida. Facultat d'Infermeria

Subjects
Càncer en els infants, Oncologia infantil, Tractament pal·liatiu, Dolor oncològic, Cures pal·liatives pediàtriques
Abstract

Introducció: Les cures pal·liatives pediàtriques destinades a malalties com el càncer són molt complexes i engloben moltes situacions. El dolor és el símptoma que més incidència té en el pacient pediàtric oncològic i, per tant, el personal sanitari ha de procurar en tot moment el control d’aquest. A part de la teràpia farmacològica per disminuir-lo també hi ha una gran varietat de teràpies complementàries que, combinades, potencien l’efecte. D’aquestes, la risoteràpia està molt indicada per aquest tipus de pacients; per tant, és important estudiar correctament la seva efectivitat i fomentar-la. Objectiu: Demostrar l'eficàcia de la risoteràpia com a tècnica complementaria utilitzada en les Cures Pal·liatives Pediàtriques per alleugerir el dolor en nens oncològics de 6 a 12 anys en l’àmbit hospitalari. Metodologia: Es realitzarà un estudi transversal analític experimental en un hospital pediàtric que compti amb un programa de pallassos d’hospital. S’utilitzaran dos grups randomitzats: el grup A (grup experimental) se li realitzaran les sessions de risoteràpia mentre que al grup B (grup control) no se li efectuarà aquesta teràpia ni cap altra de complementària; a fi de poder comparar l’estat del dolor al finalitzar la setmana. L’estudi tindrà una durada d’un any al final del qual es sumaran els resultats de totes les intervencions realitzades cada setmana. La població diana estarà formada per nens oncològics pal·liatius d’ambdós sexes d’entre 6 i 12 anys que precisin hospitalització, independentment del tipus de càncer, de l’estadi i de l’etapa d’acceptació del dol en que es trobin. Per recollir les dades es farà servir un registre on s’inclourà la valoració del dolor mitjançant l’escala dels Rostres Wong-Baker, efectuada per la infermera encarregada a l’inici i final de la setmana. Conclusions: Tot i existir pocs estudis destinats a la risoteràpia es considera una tècnica útil per fer disminuir el dolor amb nens en càncer. A més, és una teràpia amb pocs costos econòmics i sense efectes secundaris.

Published
2014

49. Interhemispheric CA1 projections support spatial cognition and are affected in a mouse model of the 22q11.2 deletion syndrome.

Author

de León Reyes NS, Bortolozzo-Gleich MH, Nomura Y, Fregola CG, Nieto M, Gogos JA, and Leroy F

Abstract

Untangling the hippocampus connectivity is critical for understanding the mechanisms supporting learning and memory. However, the function of interhemispheric connections between hippocampal formations is still poorly understood. So far, two major hippocampal commissural projections have been characterized in rodents. Mossy cells from the hilus of the dentate gyrus project to the inner molecular layer of the contralateral dentate gyrus and CA3 and CA2 pyramidal neuron axonal collaterals to contralateral CA3, CA2 and CA1. In contrary, little is known about commissural projection from the CA1 region. Here, we show that CA1 pyramidal neurons from the dorsal hippocampus project to contralateral dorsal CA1 as well as dorsal subiculum. We further demonstrate that the interhemispheric projection from CA1 to dorsal subiculum supports spatial memory and spatial working memory in WT mice, two cognitive functions impaired in male mice from the Df16(A) +/- model of 22q11.2 deletion syndrome (22q11.2DS) associated with schizophrenia. Investigation of the CA1 interhemispheric projections in Df16(A) +/- mice revealed that these projections are disrupted with male mutants showing stronger anatomical defects compared to females. Overall, our results characterize a novel interhemispheric projection from dCA1 to dorsal subiculum and suggest that dysregulation of this projection may contribute to the cognitive deficits associated with the 22q11.2DS.

Published
2024
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50. Novel flaviviruses detected in different species of mosquitoes in Spain.

Author

Vázquez A, Sánchez-Seco MP, Palacios G, Molero F, Reyes N, Ruiz S, Aranda C, Marqués E, Escosa R, Moreno J, Figuerola J, and Tenorio A

Subjects
Animals, Base Sequence, Culex virology, Female, Flavivirus genetics, Flavivirus isolation & purification, Flavivirus Infections transmission, Male, Molecular Sequence Data, Ochlerotatus virology, Polymerase Chain Reaction, RNA, Viral genetics, Reverse Transcriptase Polymerase Chain Reaction, Sequence Analysis, DNA, Spain epidemiology, Culicidae virology, Flavivirus classification, Insect Vectors virology, Phylogeny, Viral Nonstructural Proteins genetics
Abstract

We report the characterization of three novel flaviviruses isolated in Spain. Marisma Mosquito virus, a novel mosquito borne virus, was isolated from Ochlerotatus caspius mosquitoes; Spanish Ochlerotatus flavivirus and Spanish Culex flavivirus, two novel insect flaviviruses, were isolated from Oc. caspius and Culex pipiens, respectively. During this investigation, we designed a sensitive RT-nested polymerase chain reaction method that amplifies a 1019bp fragment of the flavivirus NS5 gene and could be directly used in clinical or environmental samples for flavivirus characterization and surveillance. Analysis of the sequence generated from that amplicon contains enough phylogenetic information for proper taxonomic studies. Moreover, the use of this tool allowed the detection of additional flavivirus DNA forms in Culex, Culiseta, and Ochlerotatus mosquitoes.

Published
2012
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