1. Developmental hemostasis in the neonatal period.
- Author
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Rey Y Formoso V, Barreto Mota R, and Soares H
- Subjects
- Adult, Child, Humans, Infant, Newborn, Blood Coagulation, Hemostasis
- Abstract
Background: The hemostatic system is complex and evolves continuously since gestation and well into the adult years, in a process known as "developmental hemostasis.", Data Sources: A comprehensive review was performed after an extensive literature search on PubMed/MEDLINE concerning developmental hemostasis during the neonatal period. Relevant cross references were also included., Results: Although part of a system, each component of the hemostatic system evolves differently, with many displaying both quantitative and qualitative age-related differences. This leads to drastic disparities between the coagulation system of neonates and both other children's and adults', while still maintaining a generally balanced and physiological hemostasis. The motives behind this process remain to be fully elucidated but may be, at least in part, related to non-hemostatic factors., Conclusions: Knowledge regarding "developmental hemostasis" is essential for everyone caring for newborns or even children in general and in this review, we describe each hemostatic system component's neonatal characteristics and age-related progression as well as explore some of the possible physiological motives behind the process., (© 2021. Children's Hospital, Zhejiang University School of Medicine.)
- Published
- 2022
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