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1. L-carnitine supplementation in patients with HIV/AIDS and fatigue: a double-blind, placebo-controlled pilot study

Author

Cruciani RA, Revuelta M, Dvorkin E, Homel P, Lesage P, and Esteban-Cruciani N

Subjects
Immunologic diseases. Allergy, RC581-607
Abstract

Ricardo A Cruciani,1 Manuel Revuelta,2 Ella Dvorkin,3 Peter Homel,4 Pauline Lesage,5 Nora Esteban-Cruciani6 1Center for Comprehensive Pain Management and Palliative Care, Capital Institute for Neurosciences, Capital Health Medical Center, Pennington, NJ, 2Lee Memorial Hospital, Fort Myers, FL, 3Institutional Review Board, New York University, New York, NY, 4Department of Pain Medicine and Palliative Care, Beth Israel Medical Center, New York, NY, 5Maimonides Medical Center, Brooklyn, NY, 6Children's Hospital at Montefiore, Albert Einstein College of Medicine, Bronx, NY, USA Background: The purpose of this study was to determine the effect of L-carnitine supplementation on fatigue in patients with terminal human immunodeficiency virus/acquired immune deficiency syndrome (HIV/AIDS). Methods: In this randomized, double-blind, placebo-controlled, parallel-group study, patients who had end-stage HIV/AIDS with carnitine deficiency and fatigue received 3 g of oral L-carnitine or placebo for 2 weeks, followed by a 2-week, open-label phase with the same amount of L-carnitine for all patients. The primary outcome was the degree of fatigue according to the Brief Fatigue Inventory. Secondary outcomes included serum carnitine and lactate levels, physical, emotional, social, and functional well-being, performance status, mood, and CD4 count. Results: Eighteen patients in the treatment arm and 17 in the placebo arm completed the trial. At the end of the double-blind phase, total and free carnitine levels in the treatment arm rose from 28±9 to 48±17 nM/L (P

Published
2015

4. Quality of Life Marketing, Innovation and Change Management: The Rasti Robotics and Education Team

Author

Ordóñez y Revuelta, M. Elena, Rodríguez Mincey, Daniela Nicole, Nogaró, Jazmín, Rivera, Reynaldo G., Sirgy, Joe, Editorial Board Member, Alves, Helena, Series Editor, Tonon, Graciela, Editorial Board Member, Kraeger, Patsy, Editorial Board Member, Sarracino, Francesco, Editorial Board Member, Ludwigs, Kai, Editorial Board Member, Galan-Ladero, M. Mercedes, editor, and Rivera, Reynaldo G., editor

Published
2021
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5. On the Frobenius Number of Fibonacci Numerical Semigroups

Author

Marin, J. M., Alfonsin, J. Ramirez, and Revuelta, M. P.

Subjects
Mathematics - Combinatorics
Abstract

In this paper we compute the Frobenius number of certain {\em Fibonacci numerical semigroups}, that is, numerical semigroups generated by a set of Fibonacci numbers, in terms of Fibonacci numbers., Comment: 10 pages

Published
2006

6. Hexagonal Tilings and Locally C6 Graphs

Author

Garijo, D., Gitler, I., Marquez, A., and Revuelta, M. P.

Subjects
Mathematics - Combinatorics, 05C10
Abstract

We give a complete classification of hexagonal tilings and locally C6 graphs, by showing that each of them has a natural embedding in the torus or in the Klein bottle. We also show that locally grid graphs are minors of hexagonal tilings (and by duality of locally C6 graphs) by contraction of a perfect matching and deletion of the resulting parallel edges, in a form suitable for the study of their Tutte uniqueness., Comment: 14 figures

Published
2005

7. Hexagonal Tilings: Tutte Uniqueness

Author

Garijo, D., Marquez, A., and Revuelta, M. P.

Subjects
Mathematics - Combinatorics, 05C10
Abstract

We develop the necessary machinery in order to prove that hexagonal tilings are uniquely determined by their Tutte polynomial, showing as an example how to apply this technique to the toroidal hexagonal tiling., Comment: 12 figures

Published
2005

23. Pattern of long-term weight and metabolic changes after a first episode of psychosis: Results from a 10-year prospective follow-up of the PAFIP program for early intervention in psychosis cohort

Author

Vázquez-Bourgon, J., primary, Gómez-Revuelta, M., additional, Mayoral-van Son, J., additional, Labad, J., additional, Ortiz-García de la Foz, V., additional, Setién-Suero, E., additional, Ayesa-Arriola, R., additional, Tordesillas-Gutiérrez, D., additional, Juncal-Ruiz, M., additional, and Crespo-Facorro, B., additional

Published
2022
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30. How to have an acute gastroenteritis and an Anxiety Disorder at the same time: Cannabinoid hyperemesis syndrome (CHS) Case Series.

Author

Hernández Liebo, P. A., Romay González, J., Sevilla Díez, C., Anabitarte Bautista, O. S., Cayón de la Hoz, L., Cortez Astudillo, G. E., Polo Gay, M., Obeso Menéndez, R., Hoyuelos Cob, M., and Gómez Revuelta, M.

Subjects
CANNABINOID hyperemesis syndrome, HOT water, ANXIETY disorders, TEMPERANCE, PHYSICIANS
Abstract

Introduction: Cannabinoid hyperemesis syndrome (CHS) is an underrecognized condition characterized by acute episodes of intractable nausea and vomiting, colic abdominal pain and restlessness related to chronic cannabis use. Antiemetics commonly fail to alleviate the severe nausea and vomiting. A very particular finding is the symptomatic relief with hot water. Antipsychotics (such as haloperidol), benzodiazepines and/or capsaicin cream appear to be the most efficacious in the treatment of this unique disorder. Precisely, it has been studied that transient relief of symptoms with topic capsaicin or hot water share the same pathophysiology. Nevertheless, abstinence from cannabis remains the most effective way of mitigating morbidity associated with CHS. Objectives: The objective is to study this phenomenom in our hospital and to alert of its existence in order to avoid a suspected misdiagnosis and overdiagnosis. Methods: We report a case series of seven patients who attended the Emergency Room (ER) of a third level hospital located in Cantabria (Spain) where a psychiatric evaluation was demanded. Results: The reasons for consultation were agitation and/or compulsive vomit provocation and showers. They were all women, with a median age of 29 years (range 21 to 38), who all smoked cannabis and in probable high doses (seven to up to twenty joints per day, information was missing in three of the patients) and probable long duration of consumption (more than nine years up to twenty-three, information was missing in three of the patients). One of the most striking findings is the time to diagnosis, being the median of years of more than eight (range from two to twenty-one). In all of the cases there is a hyperfrequentation to the ER for this reason (not counting other emergency centres we have in Cantabria which we don´t have access to), being the average of almost twenty-two times (thirteen up to thirty times), not diagnosing it until last visits. Another interesting fact is that Psychiatric evaluation is done approximately in a third of the visits, being the department that makes all of the diagnosis except in one case. In all of the cases there are a lot of diagnostic orientation doubts from different medical departments, being the two most common psychiatric misdiagnosis: Other Specified Anxiety Disorder and Other Specified Feeding or Eating Disorder. Two of the patients were hospitalized in an acute psychiatric unit for this reason, one of them nine times and the other patient, twice. Conclusions: CHS has a very particular presentation which makes its recognition very simple. From our experience, it is an unknown entity for most of the doctors, something that needs to change in order to make a correct therapeutic management. Larger studies need to be done to make this findings more solid and for further information. Disclosure of Interest: None Declared [ABSTRACT FROM AUTHOR]

Published
2024
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39. Current concepts in the diagnosis and management of metabolic complications of HIV infection and its therapy

Author

Wohl, D.A., McComsey, G., Tebas, P., Brown, T.T., Glesby, M.J., Reeds, D., Shikuma, C., Mulligan, K., Dube, M., Wininger, D., Huang, J., Revuelta, M., Swindells, S., Fichtenbaum, C., Basar, M., Tungsiripat, M., Meyer, W., Weihe, J., and Wanke, C.

Subjects
HIV infection -- Complications and side effects, Metabolic diseases -- Diagnosis, Metabolic diseases -- Care and treatment, Health, Health care industry
Published
2006

46. Is smoking cannabis protective effect against metabolic alterations in psychosis? Results From a 3-years longitudinal study on patients with a first-episode of psychosis

Author

Vázquez-Bourgon, Javier, Romero-Jiménez, Rodrigo, Gómez Revuelta, M., Pilar-Cuéllar, Fuencisla, Castro, Elena, and Crespo-Facorro, Benedicto

Abstract

Resumen del trabajo presentado en 26th European Congress of Psychiatry, celebrado en Niza (Francia) del 03 al 06 de marzo de 2018., [Background]: Cannabis smoking is highly prevalent among patients with a psychotic disorder. Its use has been found related to clinical characteristics of the disorder including age of onset, symptoms¿ severity and cognitive impairment. However, recent studies, both in healthy subjects and patients with psychosis, propose a possible protective effect of cannabis on weight gain and related metabolic alterations. Even so, there are no previous studies on the long-term longitudinal effect of cannabis on first-episode drug-naïve patients, thus not avoiding confounding effects of chronicity and previous treatment exposure. We aimed to explore the effect of cannabis smoking on weight and lipid/glycemic metabolic measures in a sample of first-episode non-affective psychosis patients., [Material and methods]: Anthropometric measurements and glycemic and lipid parameters were obtained at baseline and after 3 years of having initiated treatment. Patients were divided into two groups depending on self-reported cannabis use (cannabis users and non-users)., [Results]: Cannabis users presented at baseline lower weight (F = 14.85, P < 0.001), BMI (F = 13.14, P < 0.001), total cholesterol (F = 4.85, P = 0.028) and LDL-cholesterol (F = 6.26, P = 0.013), than non-users. These differences were also observed at 3 years: weight (F = 8.07, P = 0.005), BMI (F = 4.66, P = 0.032) and LDL-cholesterol (F = 3.91, P = 0.049)., [Conclusions]: Our results support the hypothesis that cannabis has a protective effect against weight gain and related metabolic alterations that are frequently observed in psychotic patients. However, this positive effect does not overcome the well known negative impact of cannabis on psychosis prognosis. Thus, clinicians should continue recommending cannabis use cessation, although being aware of a probable occurrence of a deterioration in metabolic parameters.

Published
2018

50. Phenomenology of summer ozone episodes over the Madrid Metropolitan Area, central Spain

Author

Ministerio de Economía y Competitividad (España), Querol, Xavier, Alastuey, Andrés, Gangoiti, G., Pérez, Noemí, Lee, Hongku, Eun, Hee Ram, Park, Yonghee, Mantilla, Enrique, Escudero, Miguel, Titos, Gloria, Alonso, Lucio A., Temime-Roussel, Brice, Marchand, Nicolas, Moreta, Juan R., Revuelta, M. A., Salvador, Pedro, Artíñano, Begoña, García dos Santos Alves, Saúl, Anguas, Mónica, Notario, Alberto, Saiz-Lopez, A., Harrison, Roy M., Millán, Millán M., Ahn, Kang-Ho, Ministerio de Economía y Competitividad (España), Querol, Xavier, Alastuey, Andrés, Gangoiti, G., Pérez, Noemí, Lee, Hongku, Eun, Hee Ram, Park, Yonghee, Mantilla, Enrique, Escudero, Miguel, Titos, Gloria, Alonso, Lucio A., Temime-Roussel, Brice, Marchand, Nicolas, Moreta, Juan R., Revuelta, M. A., Salvador, Pedro, Artíñano, Begoña, García dos Santos Alves, Saúl, Anguas, Mónica, Notario, Alberto, Saiz-Lopez, A., Harrison, Roy M., Millán, Millán M., and Ahn, Kang-Ho

Abstract

Various studies have reported that the photochemical nucleation of new ultrafine particles (UFPs) in urban environments within high insolation regions occurs simultaneously with high ground ozone (O3) levels. In this work, we evaluate the atmospheric dynamics leading to summer O3 episodes in the Madrid air basin (central Iberia) by means of measuring a 3-D distribution of concentrations for both pollutants. To this end, we obtained vertical profiles (up to 1200m above ground level) using tethered balloons and miniaturised instrumentation at a suburban site located to the SW of the Madrid Metropolitan Area (MMA), the Majadahonda site (MJDH), in July 2016. Simultaneously, measurements of an extensive number of air quality and meteorological parameters were carried out at three supersites across the MMA. Furthermore, data from O3 soundings and daily radio soundings were also used to interpret atmospheric dynamics. The results demonstrate the concatenation of venting and accumulation episodes, with relative lows (venting) and peaks (accumulation) in O3 surface levels. Regardless of the episode type, the fumigation of high-altitude O3 (arising from a variety of origins) contributes the major proportion of surface O3 concentrations. Accumulation episodes are characterised by a relatively thinner planetary boundary layer (< 1500m at midday, lower in altitude than the orographic features), light synoptic winds, and the development of mountain breezes along the slopes of the Guadarrama Mountain Range (located W and NW of the MMA, with a maximum elevation of > 2400ma.s.l.). This orographic-meteorological setting causes the vertical recirculation of air masses and enrichment of O3 in the lower tropospheric layers. When the highly polluted urban plume from Madrid is affected by these dynamics, the highest Ox (O3CNO2) concentrations are recorded in the MMA. Vertical O3 profiles during venting episodes, with strong synoptic winds and a deepening of the planetary boundary layer re

Published
2018

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