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Nanotechnology provides a very good chance to research and develop multipurpose nanomaterials because of their smaller size, larger surface area, low cost, and nanoscale materials, which are auspicious tools for many biological applications. The AgVO3 nanoparticle synthesis employing plant extract has offered an eco-friendly alternative for the industry. Literature survey shows that no research has been performed on AgVO3 using jackfruit; hence, we prepared AgVO3 using jackfruit extract as a reducing agent by a simple, easy, and eco-friendly precipitation method. The characterization techniques used for synthesized AgVO3 nanoparticles were x-ray diffraction analysis, which determines the monoclinic structure of synthesized AgVO3 nanoparticles; Fourier transform infrared spectroscopy, which shows the bonding of V–O–V; and scanning electron microscopy and energy dispersive spectra (EDS), which confirm the size, shape, purity, and elemental composition. Brunauer–Emmett–Teller analysis confirms the pore size, pore volume, and surface area of synthesized AgVO3 nanoparticles, Raman studies show the crystalline property, and UV–Vis studies give information about the material's formation and optical properties. The bandgap was calculated to be 2.54 eV. Furthermore, the photocatalytic studies show 98.14% degradation in 180 min using MB dye. We also performed scavenger studies for detection of OH· radicals and recyclability. Gram-negative (Klebsiella pneumonia and Pseudomonas aeruginosa) and gram-positive (Staphylococcus aureus and Bacillus subtilis) micro-organisms were used to determine the antimicrobial characteristics. The full analysis verifies AgVO3's antibacterial activity against both gram-negative and gram-positive bacteria, as well as its excellent photocatalytic activities for the degradation of the organic dye methylene blue with a high degree of recyclability. [ABSTRACT FROM AUTHOR]

Present work describes the UV–Visible and FT-IR spectral behavior of highly functionalized diarylmethanes via theoretical investigations. Analyses of both theoretical and experimental UV data were in good agreement with the assigned bands. In addition, calculations pertaining to natural bond orbitals (NBOs) and mapped molecular electrostatic potential surface (MEPS) were also performed, revealing that the strongest hyperconjugative intramolecular interactions involves the π ⟶ π∗, LP ⟶ σ∗ and n → π * transitions in the D and A rings. Further, the theoretical vibrational analysis revealed several characteristic vibrations that may be used as a diagnostic tool for other diarylmethanes and also indicated that the experimental bands related to the nitrile group occur in regions lower than usual, which confirms high conjugation of the triple bond with the aromatic system. Molecular dynamics (MD) and molecular docking calculations were performed in order to evaluate the behavior of such molecules in aqueous medium and the pharmacological potential. Another interesting observation in this study is the HOMO–LUMO analysis, which showed that the global reactivity values changed according to the type of substituent groups. [ABSTRACT FROM AUTHOR]

A bidentate (N- and O-) imine-based ligand (L1) and its metal complexes of types [CuII(L1)2] (C1), [CuII(L1)(Phen)] (C2), [CoIII(L1)2] (C3), and [CoIII(L1)(Phen)] (C4) (L1 = 2-((E)-(6-fluorobenzo[d]thiazol-2-ylimino)methyl)-4-chlorophenol and phen = 1,10-phenanthroline) were synthesized as potential chemotherapeutic drug candidates. The prepared complexes were structurally characterized by spectral techniques (NMR, FT-IR, LC-MS, EPR, and electronic absorption), thermogravimetric analysis (TGA/DTA), magnetic moment, and CHNO elemental analysis. Spectroscopic studies suggested the distorted octahedral structure for all complexes. In vitro bioassay studies include binding and nuclease activities of the ligand and its complexes with target calf thymus-(CT-) DNA were carried out by employing UV-Vis, fluorescence spectroscopy, viscosity, and gel electrophoresis techniques. The extent of binding propensity was determined quantitatively by Kb and Ksv values which revealed a higher binding affinity for C2 and C4 as compared to C1 and C3. In addition, the scavenging superoxide anion free radical (O∙−2) activity of metal complexes was determined by nitroblue tetrazolium (NBT) light reduction assay. Molecular docking studies with DNA and SOD enzyme were also carried out on these compounds. The antimicrobial study has shown that all the compounds are potential antibacterial agents against Gram-negative bacterial strains and better antifungal agents with respect to standard drugs used. [ABSTRACT FROM AUTHOR]

Background: Sparse data are available documenting similarities and differences in the clinical, bacteriological and radiographic features of pulmonary tuberculosis (TB) in persons aged over 60 years and those aged under 60 years. Materials and Methods: We prospectively studied 100 adult patients with pulmonary TB aged 18-59 years (n=50) and 60 years and above (n=50; elderly subjects) who presented to the medicine out-patient service and were admitted in the medical wards at our medical college teaching hospital at Kuppam, Andhra Pradesh. Results: In both the groups, males were in the majority (72% in geriatric and 60% in adult group). Hemoptysis (26% in geriatric and 42% in adult) and night sweats (12% in geriatric and 58% in adult) were frequent in adults than geriatric patients. Chronic obstructive pulmonary disease(COPD),Hypertension and diabetes mellitus were more frequent in geriatric patients than 18-59 year old adults. Cavitations were more common in adults, whereas lower lobe involvement was more frequent in the geriatric group. In the geriatric patients 72% were completely cured compared to 92% in adult patients. Treatment failure was 20% in geriatric group compared to 6% in adults. Mortality was 8% in geriatric and 2% in adults. Adverse reactions were frequent in geriatric group (n=20) than 18-59 year old individuals. Conclusion: The present study documents important differences in clinical and radiological presentation of pulmonary TB in geriatric patients compared with adults aged 18-59 years. Geriatric patients also experienced more frequent occurrence of adverse reactions, failure of treatment and mortality. [ABSTRACT FROM AUTHOR]