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22 results on '"Reus, Astrid A."'

6. Guidance document on the impact of water treatment processes on residues of active substances or their metabolites in water abstracted for the production of drinking water.

Author

Hofman‐Caris, Roberta, Dingemans, Milou, Reus, Astrid, Shaikh, Sanah Majid, Muñoz Sierra, Julian, Karges, Ursula, Beek, Tim aus der, Nogueiro, Eugénia, Lythgo, Christopher, Parra Morte, Juan Manuel, Bastaki, Maria, Serafimova, Rositsa, Friel, Anja, Court Marques, Daniele, Uphoff, Andreas, Bielska, Lucie, Putzu, Claudio, Ruggeri, Laura, and Papadaki, Paschalina

Subjects
WATER purification, DRINKING water, PUBLIC health, PURCHASING power parity, WATER shortages, ANIMAL health, RISK managers
Abstract

This guidance document provides a tiered framework for risk assessors and facilitates risk managers in making decisions concerning the approval of active substances (AS) that are chemicals in plant protection products (PPPs) and biocidal products, and authorisation of the products. Based on the approaches presented in this document, a conclusion can be drawn on the impact of water treatment processes on residues of the AS or its metabolites in surface water and/or groundwater abstracted for the production of drinking water, i.e. the formation of transformation products (TPs). This guidance enables the identification of actual public health concerns from exposure to harmful compounds generated during the processing of water for the production of drinking water, and it focuses on water treatment methods commonly used in the European Union (EU). The tiered framework determines whether residues from PPP use or residues from biocidal product use can be present in water at water abstraction locations. Approaches, including experimental methods, are described that can be used to assess whether harmful TPs may form during water treatment and, if so, how to assess the impact of exposure to these water treatment TPs (tTPs) and other residues including environmental TPs (eTPs) on human and domesticated animal health through the consumption of TPs via drinking water. The types of studies or information that would be required are described while avoiding vertebrate testing as much as possible. The framework integrates the use of weight‐of‐evidence and, when possible alternative (new approach) methods to avoid as far as possible the need for additional testing. [ABSTRACT FROM AUTHOR]

Published
2023
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9. Voorspellen van de vorming van transformatieproducten tijdens drinkwaterbehandeling en hun mogelijke toxiciteit

Author

Ferrario, Adele S., Dingemans, Milou, Reus, Astrid, Hofman-Caris, Carola, Ferrario, Adele S., Dingemans, Milou, Reus, Astrid, and Hofman-Caris, Carola

Abstract

Zuivering van water is essentieel voor drinkwaterproductie, maar kan onbedoeld ansformatieproducten opleveren. Identificatie van deze producten en hun toxiciteit is nodig om veilig drinkwater te waarborgen. Voorspellende toxicologie kan de beoordeling van deze stoffen versnellen en verbeteren., Zuivering van water is essentieel voor drinkwaterproductie, maar kan onbedoeld transformatieproducten opleveren. Identificatie van deze producten en hun toxiciteit is nodig om veilig drinkwater te waarborgen. Voorspellende toxicologie kan de beoordeling van deze stoffen versnellen en verbeteren.

Published
2022

12. Improved Drinking Water Quality after Adding Advanced Oxidation for Organic Micropollutant Removal to Pretreatment of River Water Undergoing Dune Infiltration Near the Hague, Netherlands

Author

Timmers, Peer, primary, Slootweg, Tineke, additional, Knezev, Aleksandra, additional, van der Schans, Martin, additional, Zandvliet, Luc, additional, Reus, Astrid, additional, Vughs, Dennis, additional, Heijnen, Leo, additional, Knol, Ton, additional, El Majjaoui, Jamal, additional, van der Wielen, Paul, additional, Stuyfzand, Pieter, additional, and Lekkerkerker, Karin, additional

Published
2021
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16. Coffee and oxidative stress: a human intervention study

Author

Shaposhnikov, Sergey, primary, Hatzold, Thomas, additional, Yamani, Naouale El, additional, Stavro, Philip Mark, additional, Lorenzo, Yolanda, additional, Dusinska, Maria, additional, Reus, Astrid, additional, Pasman, Wilrike, additional, and Collins, Andrew, additional

Published
2016
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17. The EURL ECVAM - Cosmetics Europe prospective validation study of Reconstructed human Cornea-like Epithelium (RhCE)-based test methods for identifying chemicals not requiring classification and labelling for serious eye damage/eye irritation: Validation Study Report

Author

VIEGAS BARROSO JOAO FILIPE, ALÉPÉE Nathalie, COLE Thomas, ESKES Chantra, FREEMAN Stuart, LISKA Roman, MCNAMEE Pauline, PFANNENBECKER Uwe, REUS Astrid, RUBINGH Carina, SCHAEFFER MICHAEL WILHELM, and ZUANG Valerie

Abstract

A prospective validation study of two Reconstructed human Tissue-based in vitro test methods (EpiOcular™ EIT and SkinEthic™ HCE) was conducted by EURL ECVAM and Cosmetics Europe to evaluate their usefulness to identify chemicals as either not classified for serious eye damage/eye irritation (No Category) or as classified (Category 1/Category 2) within UN GHS, in the framework of a Bottom-Up/Top-Down test strategy [1]. The study assessed the validity of two EpiOcular™ EIT protocols for liquids and solids, two independent SkinEthic™ HCE protocols based on short-time (SE) and long-time (LE) exposures and a test strategy combining SE and LE. The results and conclusions of this study will be presented. Briefly, over 100 chemicals were tested and both methods showed high reproducibility (>90%). The EpiOcular™ EIT liquids protocol met all the study acceptance criteria for predictive capacity [2], but not all of these criteria were met by the solids protocol nor by any of the SkinEthic™ HCE protocols/strategy. This led to optimisation of the EpiOcular™ EIT solids protocol and further validation being conducted. With final sensitivity of 96%, specificity of 63% and accuracy of 80%, the EpiOcular™ EIT met all the study acceptance criteria and is considered valid for the proposed study objective., JRC.I.5-Systems Toxicology

Published
2014

18. The role of oxidative stress in the differential effects between n−3 and n−6 polyunsaturated fatty acids and the protective effects of algal and fish oil in colon carcinogenesis

Author

Alink, Gerrit, primary, van Beelen, Vincent, additional, Aarts, Jac, additional, Bino, Raoul, additional, Bosch, Dirk, additional, Hooiveld, Guido, additional, Mooibroek, Hans, additional, Muller, Michael, additional, Reus, Astrid, additional, Roeleveld, Johannes, additional, Sijtsma, Lolke, additional, Spenkelink, Bert, additional, and Rietjens, Ivonne, additional

Published
2007
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21. Differential induction of electrophile-responsive element-regulated genes by n −3 and n −6 polyunsaturated fatty acids

Author

van Beelen, Vincent A., Aarts, Jac M.M.J.G., Reus, Astrid, Mooibroek, Hans, Sijtsma, Lolke, Bosch, Dirk, Rietjens, Ivonne M.C.M., and Alink, Gerrit M.

Subjects
DOCOSAHEXAENOIC acid, OMEGA-3 fatty acids, ORGANOMETALLIC compounds, METALLOTHIONEIN
Abstract

Abstract: In this study the n −3 polyunsaturated fatty acids (PUFAs) eicosapentaenoic acid and docosahexaenoic acid appear to be effective inducers of electrophile-responsive element (EpRE) regulated genes, whereas the n −6 PUFA arachidonic acid is not. These n −3 PUFAs need to be oxidized to induce EpRE-regulated gene expression, as the antioxidant vitamin E can partially inhibit the PUFA induced dose-dependent effect. Results were obtained using a reporter gene assay, real-time RT-PCR and enzyme activity assays. The induction of EpRE-regulated phase II genes by n −3 PUFAs may be a major pathway by which n −3 PUFAs, in contrast to n −6 PUFAs, are chemopreventive and anticarcinogenic. [Copyright &y& Elsevier]

Published
2006
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