1. Interrogating the roles of lymph node metastasis in systemic immune surveillance.
- Author
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Basto PA and Reticker-Flynn NE
- Subjects
- Humans, Neoplasms immunology, Neoplasms pathology, Immunotherapy methods, Immune Checkpoint Inhibitors therapeutic use, Animals, Neoadjuvant Therapy, Lymph Node Excision, Tumor Microenvironment immunology, Lymphatic Metastasis, Immunologic Surveillance, Lymph Nodes pathology, Lymph Nodes immunology
- Abstract
Lymph nodes (LNs) are principal orchestrators of the adaptive immune response, yet in the context of malignancy, they are typically the first sites of metastasis. When tumors spread to LNs, they alter the immune repertoire, ultimately reconditioning it in a manner that suppresses anti-tumor immunity and promotes further metastatic dissemination. Conversely, activation of anti-tumor immunity within LNs is essential for immunotherapy, suggesting clinical approaches to radiotherapy in LNs and lymphadenectomy may need to be reconsidered in the context of immune checkpoint blockade (ICB). Herein, we discuss our understanding of the immune remodeling that coincides with LN metastasis as well as recent clinical studies exploring neoadjuvant immunotherapy and the roles of LNs in treatment of solid organ malignancies., (© 2024. The Author(s), under exclusive licence to Springer Nature B.V.)
- Published
- 2024
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