1. Engineering Approach to the Study of Short Term Periodicities in Human Metabolism
- Author
-
R. M. Greenway, Paul H. King, H. P. Apple, W.R. Baker, O. Lindan, and Reswick Jb
- Subjects
medicine.medical_specialty ,Meal ,Food intake ,Human metabolism ,Biology ,Diurnal rhythms ,Term (time) ,Excretion ,Animal science ,Endocrinology ,Internal medicine ,Heart rate ,medicine ,Physiological monitoring - Abstract
An engineering system analysis of “the input-output relationships” has been adapted to the study of metabolic fluctuations in man, on an hourly basis. All subjects, normal controls and those paralysed due to spinal cord injury, were studied for 14-31 day periods in the controlled environment of a metabolic ward. In order to separate the effects of meals, body position changes and “diurnal clocks” on the urine excretion patterns, body temperature and heart rate, “synthetic living schedules” were designed and applied as part of the input control of the subjects. These included: (a) a "nibbling schedule", with meals served every 4 hours day and night, (b) a "19-hr. schedule", in which one large meal was given every 19 hours, (c) a "random schedule", with meals separated by random spacings. The collection and numerical analysis of the required volume of data (up to 2000 hourly data per Week) was made possible by the development of an "Automated 25-Channel Data Acquisition System" linked to a computing facility. This allowed us (a) to uncover the diurnal rhythms in renal function, heart rate and body temperature, (b) to isolate various renal excretion patterns as influenced by various external factors (like diet composition, meal scheduling and body position), (c) to quantitate the periodicity strength and the level of the "noise component" in data obtained during physiological monitoring, (d) to assess the effects of diurnal rhythms and food intake on steroid regulation of urinary excretion of metabolites.
- Published
- 1968