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498 results on '"Respiratory system agents -- Health aspects"'

1. Using Arginine-Glycine-Aspartic Acid (RGD)-Tumor Necrosis Factor (TNF) Modified Phage for Lung Cancer Treatment: Suppressing Tumor Mass Growth and Tumor Marker Expressions in Nude Mouse Model / Uso de Fagos Modificados con Factor de Necrosis Tumoral (TNF) y Acido Aspartico-Arginina (RGD) para el Tratamiento del Cancer de Pulmdn: Supresidn del Crecimiento de la Masa Tumoral y de la Expresidn de Marcadores Tumorales en un Modelo de Raton Nude

Author

Fongmoon, Duriya, Hajitou, Amin, Suwan, Keittisak, Taengoon, Chanathip, Nagong, Minta, Luangyai, Rungtiwa, Bunsueb, Sudtida, and Iamsaard, Sitthichai

Published
2024

2. COVID-19 drugs: Are there any that work?

Subjects
United States. Food and Drug Administration, Health aspects, Baricitinib -- Health aspects, Respiratory system agents -- Health aspects, Anakinra -- Health aspects, COVID-19 -- Health aspects, Respiratory agents -- Health aspects
Abstract

Answer Section COVID-19 medicine can help people who are at risk of, diagnosed with, or have symptoms of coronavirus disease 2019 (COVID-19). The medicine helps manage symptoms, stop the virus [...]

Published
2024

3. COVID-19 drugs: Are there any that work?

Subjects
United States. Food and Drug Administration, Health aspects, Baricitinib -- Health aspects, Respiratory system agents -- Health aspects, Anakinra -- Health aspects, COVID-19 -- Health aspects, Respiratory agents -- Health aspects
Abstract

Answer Section COVID-19 medicine can help people who are at risk of, diagnosed with, or have symptoms of coronavirus disease 2019 (COVID-19). The medicine helps manage symptoms, stop the virus [...]

Published
2024

4. COVID-19 drugs: Are there any that work?

Subjects
United States. Food and Drug Administration, Health aspects, Baricitinib -- Health aspects, Respiratory system agents -- Health aspects, Anakinra -- Health aspects, COVID-19 -- Health aspects, Respiratory agents -- Health aspects
Abstract

Answer Section COVID-19 medicine can help people who are at risk of, diagnosed with, or have symptoms of coronavirus disease 2019 (COVID-19). The medicine helps manage symptoms, stop the virus [...]

Published
2024

5. COVID-19 drugs: Are there any that work?

Subjects
United States. Food and Drug Administration, Health aspects, Baricitinib -- Health aspects, Respiratory system agents -- Health aspects, Anakinra -- Health aspects, COVID-19 -- Health aspects, Respiratory agents -- Health aspects
Abstract

Answer Section COVID-19 medicine can help people who are at risk of, diagnosed with, or have symptoms of coronavirus disease 2019 (COVID-19). The medicine helps manage symptoms, stop the virus [...]

Published
2024

6. COVID-19 drugs: Are there any that work?

Subjects
United States. Food and Drug Administration, Health aspects, Baricitinib -- Health aspects, Respiratory system agents -- Health aspects, Anakinra -- Health aspects, COVID-19 -- Health aspects, Respiratory agents -- Health aspects
Abstract

Answer Section COVID-19 medicine can help people who are at risk of, diagnosed with, or have symptoms of coronavirus disease 2019 (COVID-19). The medicine helps manage symptoms, stop the virus [...]

Published
2024

7. COVID-19 drugs: Are there any that work?

Subjects
United States. Food and Drug Administration, Health aspects, Baricitinib -- Health aspects, Respiratory system agents -- Health aspects, Anakinra -- Health aspects, COVID-19 -- Health aspects, Respiratory agents -- Health aspects
Abstract

Answer Section COVID-19 medicine can help people who are at risk of, diagnosed with, or have symptoms of coronavirus disease 2019 (COVID-19). The medicine helps manage symptoms, stop the virus [...]

Published
2024

8. COVID-19 drugs: Are there any that work?

Subjects
United States. Food and Drug Administration, Health aspects, Baricitinib -- Health aspects, Respiratory system agents -- Health aspects, Anakinra -- Health aspects, COVID-19 -- Health aspects, Respiratory agents -- Health aspects
Abstract

Answer Section COVID-19 medicine can help people who are at risk of, diagnosed with, or have symptoms of coronavirus disease 2019 (COVID-19). The medicine helps manage symptoms, stop the virus [...]

Published
2024

9. COVID-19 drugs: Are there any that work?

Subjects
United States. Food and Drug Administration, Health aspects, Baricitinib -- Health aspects, Respiratory system agents -- Health aspects, Anakinra -- Health aspects, COVID-19 -- Health aspects, Respiratory agents -- Health aspects
Abstract

Answer Section COVID-19 medicine can help people who are at risk of, diagnosed with, or have symptoms of coronavirus disease 2019 (COVID-19). The medicine helps manage symptoms, stop the virus [...]

Published
2024

10. COVID-19 drugs: Are there any that work?

Subjects
United States. Food and Drug Administration, Health aspects, Baricitinib -- Health aspects, Respiratory system agents -- Health aspects, Anakinra -- Health aspects, COVID-19 -- Health aspects, Respiratory agents -- Health aspects
Abstract

Answer Section COVID-19 medicine can help people who are at risk of, diagnosed with, or have symptoms of coronavirus disease 2019 (COVID-19). The medicine helps manage symptoms, stop the virus [...]

Published
2024

11. COVID-19 drugs: Are there any that work?

Subjects
United States. Food and Drug Administration, Health aspects, Baricitinib -- Health aspects, Respiratory system agents -- Health aspects, Anakinra -- Health aspects, COVID-19 -- Health aspects, Respiratory agents -- Health aspects
Abstract

Answer Section COVID-19 medicine can help people who are at risk of, diagnosed with, or have symptoms of coronavirus disease 2019 (COVID-19). The medicine helps manage symptoms, stop the virus [...]

Published
2024

12. COVID-19 drugs: Are there any that work?

Subjects
United States. Food and Drug Administration, Health aspects, Baricitinib -- Health aspects, Respiratory system agents -- Health aspects, Anakinra -- Health aspects, COVID-19 -- Health aspects, Respiratory agents -- Health aspects
Abstract

Answer Section COVID-19 medicine can help people who are at risk of, diagnosed with, or have symptoms of coronavirus disease 2019 (COVID-19). The medicine helps manage symptoms, stop the virus [...]

Published
2024

13. COVID-19 drugs: Are there any that work?

Subjects
United States. Food and Drug Administration, Health aspects, Baricitinib -- Health aspects, Respiratory system agents -- Health aspects, Anakinra -- Health aspects, COVID-19 -- Health aspects, Respiratory agents -- Health aspects
Abstract

Answer Section COVID-19 medicine can help people who are at risk of, diagnosed with, or have symptoms of coronavirus disease 2019 (COVID-19). The medicine helps manage symptoms, stop the virus [...]

Published
2024

14. COVID-19 drugs: Are there any that work?

Subjects
United States. Food and Drug Administration, Health aspects, Baricitinib -- Health aspects, Respiratory system agents -- Health aspects, Anakinra -- Health aspects, COVID-19 -- Health aspects, Respiratory agents -- Health aspects
Abstract

Answer Section COVID-19 medicine can help people who are at risk of, diagnosed with, or have symptoms of coronavirus disease 2019 (COVID-19). The medicine helps manage symptoms, stop the virus [...]

Published
2024

15. COVID-19 drugs: Are there any that work?

Subjects
United States. Food and Drug Administration, Health aspects, Baricitinib -- Health aspects, Respiratory system agents -- Health aspects, Anakinra -- Health aspects, COVID-19 -- Health aspects, Respiratory agents -- Health aspects
Abstract

Answer Section COVID-19 medicine can help people who are at risk of, diagnosed with, or have symptoms of coronavirus disease 2019 (COVID-19). The medicine helps manage symptoms, stop the virus [...]

Published
2024

16. COVID-19 drugs: Are there any that work?

Subjects
United States. Food and Drug Administration, Health aspects, Baricitinib -- Health aspects, Respiratory system agents -- Health aspects, Anakinra -- Health aspects, COVID-19 -- Health aspects, Respiratory agents -- Health aspects
Abstract

Answer Section COVID-19 medicine can help people who are at risk of, diagnosed with, or have symptoms of coronavirus disease 2019 (COVID-19). The medicine helps manage symptoms, stop the virus [...]

Published
2024

17. COVID-19 drugs: Are there any that work?

Subjects
United States. Food and Drug Administration, Health aspects, Baricitinib -- Health aspects, Respiratory system agents -- Health aspects, Anakinra -- Health aspects, COVID-19 -- Health aspects, Respiratory agents -- Health aspects
Abstract

Answer Section COVID-19 medicine can help people who are at risk of, diagnosed with, or have symptoms of coronavirus disease 2019 (COVID-19). The medicine helps manage symptoms, stop the virus [...]

Published
2024

18. COVID-19 drugs: Are there any that work?

Subjects
United States. Food and Drug Administration, Health aspects, Baricitinib -- Health aspects, Respiratory system agents -- Health aspects, Anakinra -- Health aspects, COVID-19 -- Health aspects, Respiratory agents -- Health aspects
Abstract

Answer Section COVID-19 medicine can help people who are at risk of, diagnosed with, or have symptoms of coronavirus disease 2019 (COVID-19). The medicine helps manage symptoms, stop the virus [...]

Published
2024

19. COVID-19 drugs: Are there any that work?

Subjects
United States. Food and Drug Administration, Health aspects, Baricitinib -- Health aspects, Respiratory system agents -- Health aspects, Anakinra -- Health aspects, COVID-19 -- Health aspects, Respiratory agents -- Health aspects
Abstract

Answer Section COVID-19 medicine can help people who are at risk of, diagnosed with, or have symptoms of coronavirus disease 2019 (COVID-19). The medicine helps manage symptoms, stop the virus [...]

Published
2024

20. COVID-19 drugs: Are there any that work?

Subjects
United States. Food and Drug Administration, Health aspects, Baricitinib -- Health aspects, Respiratory system agents -- Health aspects, Anakinra -- Health aspects, COVID-19 -- Health aspects, Respiratory agents -- Health aspects
Abstract

Answer Section COVID-19 medicine can help people who are at risk of, diagnosed with, or have symptoms of coronavirus disease 2019 (COVID-19). The medicine helps manage symptoms, stop the virus [...]

Published
2024

21. COVID-19 drugs: Are there any that work?

Subjects
United States. Food and Drug Administration, Health aspects, Baricitinib -- Health aspects, Respiratory system agents -- Health aspects, Anakinra -- Health aspects, COVID-19 -- Health aspects, Respiratory agents -- Health aspects
Abstract

Answer Section COVID-19 medicine can help people who are at risk of, diagnosed with, or have symptoms of coronavirus disease 2019 (COVID-19). The medicine helps manage symptoms, stop the virus [...]

Published
2024

22. COVID-19 drugs: Are there any that work?

Subjects
United States. Food and Drug Administration, Health aspects, Baricitinib -- Health aspects, Respiratory system agents -- Health aspects, Anakinra -- Health aspects, COVID-19 -- Health aspects, Respiratory agents -- Health aspects
Abstract

Answer Section COVID-19 medicine can help people who are at risk of, diagnosed with, or have symptoms of coronavirus disease 2019 (COVID-19). The medicine helps manage symptoms, stop the virus [...]

Published
2024

23. COVID-19 drugs: Are there any that work?

Subjects
United States. Food and Drug Administration, Health aspects, Baricitinib -- Health aspects, Respiratory system agents -- Health aspects, Anakinra -- Health aspects, COVID-19 -- Health aspects, Respiratory agents -- Health aspects
Abstract

Answer Section COVID-19 medicine can help people who are at risk of, diagnosed with, or have symptoms of coronavirus disease 2019 (COVID-19). The medicine helps manage symptoms, stop the virus [...]

Published
2024

24. COVID-19 drugs: Are there any that work?

Subjects
United States. Food and Drug Administration, Health aspects, Baricitinib -- Health aspects, Respiratory system agents -- Health aspects, Anakinra -- Health aspects, COVID-19 -- Health aspects, Respiratory agents -- Health aspects
Abstract

Answer Section COVID-19 medicine can help people who are at risk of, diagnosed with, or have symptoms of coronavirus disease 2019 (COVID-19). The medicine helps manage symptoms, stop the virus [...]

Published
2024

25. COVID-19 drugs: Are there any that work?

Subjects
United States. Food and Drug Administration, Health aspects, Baricitinib -- Health aspects, Respiratory system agents -- Health aspects, Anakinra -- Health aspects, COVID-19 -- Health aspects, Respiratory agents -- Health aspects
Abstract

Answer Section COVID-19 medicine can help people who are at risk of, diagnosed with, or have symptoms of coronavirus disease 2019 (COVID-19). The medicine helps manage symptoms, stop the virus [...]

Published
2024

26. COVID-19 drugs: Are there any that work?

Subjects
United States. Food and Drug Administration, Health aspects, Baricitinib -- Health aspects, Respiratory system agents -- Health aspects, Anakinra -- Health aspects, COVID-19 -- Health aspects, Respiratory agents -- Health aspects
Abstract

Answer Section COVID-19 medicine can help people who are at risk of, diagnosed with, or have symptoms of coronavirus disease 2019 (COVID-19). The medicine helps manage symptoms, stop the virus [...]

Published
2024

27. COVID-19 drugs: Are there any that work?

Subjects
United States. Food and Drug Administration, Health aspects, Baricitinib -- Health aspects, Respiratory system agents -- Health aspects, Anakinra -- Health aspects, COVID-19 -- Health aspects, Respiratory agents -- Health aspects
Abstract

Answer Section COVID-19 medicine can help people who are at risk of, diagnosed with, or have symptoms of coronavirus disease 2019 (COVID-19). The medicine helps manage symptoms, stop the virus [...]

Published
2024

28. COVID-19 drugs: Are there any that work?

Subjects
United States. Food and Drug Administration, Health aspects, Baricitinib -- Health aspects, Respiratory system agents -- Health aspects, Anakinra -- Health aspects, COVID-19 -- Health aspects, Respiratory agents -- Health aspects
Abstract

Answer Section COVID-19 medicine can help people who are at risk of, diagnosed with, or have symptoms of coronavirus disease 2019 (COVID-19). The medicine helps manage symptoms, stop the virus [...]

Published
2024

29. COVID-19 drugs: Are there any that work?

Subjects
United States. Food and Drug Administration, Health aspects, Baricitinib -- Health aspects, Respiratory system agents -- Health aspects, Anakinra -- Health aspects, COVID-19 -- Health aspects, Respiratory agents -- Health aspects
Abstract

Answer Section COVID-19 medicine can help people who are at risk of, diagnosed with, or have symptoms of coronavirus disease 2019 (COVID-19). The medicine helps manage symptoms, stop the virus [...]

Published
2024

30. Chronic Pulmonary Infections Pipeline 2024: Key Companies, MOA, ROA, and Clinical Trials Evaluation by DelveInsight | Teva Pharma, Merck, F. Hoffmann-La Roche, Novartis, GlaxoSmithKline, AstraZeneca

Subjects
Health aspects, Product development, Clinical trials -- Health aspects, Business research -- Health aspects, Crizotinib -- Health aspects, Lorlatinib -- Product development, Respiratory system agents -- Health aspects, Infection -- Health aspects, Lung diseases -- Health aspects, Business -- Research, Respiratory agents -- Health aspects
Abstract

M2 PRESSWIRE-January 28, 2025-: Chronic Pulmonary Infections Pipeline 2024: Key Companies, MOA, ROA, and Clinical Trials Evaluation by DelveInsight | Teva Pharma, Merck, F. Hoffmann-La Roche, Novartis, GlaxoSmithKline, AstraZeneca (C)1994-2025 [...]

Published
2025

31. COVID-19 drugs: Are there any that work?

Subjects
United States. Food and Drug Administration, Health aspects, Baricitinib -- Health aspects, Respiratory system agents -- Health aspects, Anakinra -- Health aspects, COVID-19 -- Health aspects, Respiratory agents -- Health aspects
Abstract

Answer Section COVID-19 medicine can help people who are at risk of, diagnosed with, or have symptoms of coronavirus disease 2019 (COVID-19). The medicine helps manage symptoms, stop the virus [...]

Published
2024

32. COVID-19 drugs: Are there any that work?

Subjects
United States. Food and Drug Administration, Health aspects, Baricitinib -- Health aspects, Respiratory system agents -- Health aspects, Anakinra -- Health aspects, COVID-19 -- Health aspects, Respiratory agents -- Health aspects
Abstract

Answer Section COVID-19 medicine can help people who are at risk of, diagnosed with, or have symptoms of coronavirus disease 2019 (COVID-19). The medicine helps manage symptoms, stop the virus [...]

Published
2024

33. COVID-19 drugs: Are there any that work?

Subjects
United States. Food and Drug Administration, Health aspects, Baricitinib -- Health aspects, Respiratory system agents -- Health aspects, Anakinra -- Health aspects, COVID-19 -- Health aspects, Respiratory agents -- Health aspects
Abstract

Answer Section COVID-19 medicine can help people who are at risk of, diagnosed with, or have symptoms of coronavirus disease 2019 (COVID-19). The medicine helps manage symptoms, stop the virus [...]

Published
2024

34. COVID-19 drugs: Are there any that work?

Subjects
United States. Food and Drug Administration, Health aspects, Baricitinib -- Health aspects, Respiratory system agents -- Health aspects, Anakinra -- Health aspects, COVID-19 -- Health aspects, Respiratory agents -- Health aspects
Abstract

Answer Section COVID-19 medicine can help people who are at risk of, diagnosed with, or have symptoms of coronavirus disease 2019 (COVID-19). The medicine helps manage symptoms, stop the virus [...]

Published
2024

35. COVID-19 drugs: Are there any that work?

Subjects
United States. Food and Drug Administration, Health aspects, Baricitinib -- Health aspects, Respiratory system agents -- Health aspects, Anakinra -- Health aspects, COVID-19 -- Health aspects, Respiratory agents -- Health aspects
Abstract

Answer Section COVID-19 medicine can help people who are at risk of, diagnosed with, or have symptoms of coronavirus disease 2019 (COVID-19). The medicine helps manage symptoms, stop the virus [...]

Published
2024

36. COVID-19 drugs: Are there any that work?

Subjects
United States. Food and Drug Administration, Health aspects, Baricitinib -- Health aspects, Respiratory system agents -- Health aspects, Anakinra -- Health aspects, COVID-19 -- Health aspects, Respiratory agents -- Health aspects
Abstract

Answer Section COVID-19 medicine can help people who are at risk of, diagnosed with, or have symptoms of coronavirus disease 2019 (COVID-19). The medicine helps manage symptoms, stop the virus [...]

Published
2024

37. COVID-19 drugs: Are there any that work?

Subjects
United States. Food and Drug Administration, Health aspects, Baricitinib -- Health aspects, Respiratory system agents -- Health aspects, Anakinra -- Health aspects, COVID-19 -- Health aspects, Respiratory agents -- Health aspects
Abstract

Answer Section COVID-19 medicine can help people who are at risk of, diagnosed with, or have symptoms of coronavirus disease 2019 (COVID-19). The medicine helps manage symptoms, stop the virus [...]

Published
2024

38. COVID-19 drugs: Are there any that work?

Subjects
United States. Food and Drug Administration, Health aspects, Baricitinib -- Health aspects, Respiratory system agents -- Health aspects, Anakinra -- Health aspects, COVID-19 -- Health aspects, Respiratory agents -- Health aspects
Abstract

Answer Section COVID-19 medicine can help people who are at risk of, diagnosed with, or have symptoms of coronavirus disease 2019 (COVID-19). The medicine helps manage symptoms, stop the virus [...]

Published
2024

39. COVID-19 drugs: Are there any that work?

Subjects
United States. Food and Drug Administration, Health aspects, Baricitinib -- Health aspects, Respiratory system agents -- Health aspects, Anakinra -- Health aspects, COVID-19 -- Health aspects, Respiratory agents -- Health aspects
Abstract

Answer Section COVID-19 medicine can help people who are at risk of, diagnosed with, or have symptoms of coronavirus disease 2019 (COVID-19). The medicine helps manage symptoms, stop the virus [...]

Published
2024

40. COVID-19 drugs: Are there any that work?

Subjects
United States. Food and Drug Administration, Health aspects, Baricitinib -- Health aspects, Respiratory system agents -- Health aspects, Anakinra -- Health aspects, COVID-19 -- Health aspects, Respiratory agents -- Health aspects
Abstract

Answer Section COVID-19 medicine can help people who are at risk of, diagnosed with, or have symptoms of coronavirus disease 2019 (COVID-19). The medicine helps manage symptoms, stop the virus [...]

Published
2024

41. Periodontitis Risk Factors in Adults with Cystic Fibrosis: A pilot study

Author

Alkhateeb, Alaa A., Mancl, Lloyd A., Ramos, Kathleen J., Rothen, Marilynn L., Kotsakis, Georgios A., Trence, Dace L., and Chi, Donald L.

Subjects
Prevention, Risk factors, Health aspects, Cystic fibrosis -- Risk factors -- Prevention, Respiratory system agents -- Health aspects, Diabetes therapy -- Health aspects, Medical research -- Health aspects, Toiletries industry -- Health aspects, Infection -- Risk factors -- Prevention, Periodontitis -- Risk factors -- Prevention, Adults -- Health aspects, Medicine, Experimental -- Health aspects, Respiratory agents -- Health aspects
Abstract

INTRODUCTION Cystic fibrosis (CF) is a life-limiting autosomal recessive disease that affects multiple organ systems (1). The main cause of morbidity and mortality in individuals with CF is respiratory disease [...], Purpose Individuals with cystic fibrosis (CF) present with multiple condition-specific risk factors for periodontitis including CF-related diabetes, chronic inhaled treatments that induce xerostomia, and increased systemic inflammation because of frequent lung infections. General factors like age, oral hygiene, and diet may also contribute to the risk of periodontitis. However the relative importance of these specific risk factors and periodontitis in individuals with CF has not yet been evaluated. The purpose of this pilot study was to assess the associations between CF condition-specific and general risk factors and the prevalence of periodontitis in adults with CF. Methods This cross-sectional pilot study was designed to assess a multifactorial model of periodontitis risk factors in a population in adults with CF who were recruited from the University of Washington Adult CF center. Periodontitis was defined using the Centers for Disease Control and Prevention and the American Academy of Periodontology (CDC/AAP) case definition. Risk factors included condition-specific and general factors. Differences between participants with moderate/severe periodontitis and those with no/mild periodontitis was assessed using the Mann-Whitney test, the Fisher's exact test, and the exact chi-square test ([alpha]=0.05). Results Thirty-two participants were enrolled. Twenty-eight percent of the participants had moderate periodontitis, 72% had no/mild periodontitis; none of the participants had severe periodontitis. There were no significant differences in condition-specific factors between between the two study groups. Participants with moderate periodontitis were older (p=0.028) and reported daily flossing in higher proportions than those with no/mild periodontitis (p=0.023). Conclusions The findings from this pilot study suggest that future research is needed to determine whether sociodemographic and other general risk factors are more important contributors to periodontitis risk than CF-specific factors. Keywords cystic fibrosis, periodontitis, risk factors, medically compromised, oral health NDHRA priority area, Client level: Oral health care (prevention modalities).

Published
2023

42. Avanafil as a Novel Therapeutic Agent Against LPS-Induced Acute Lung Injury via Increasing CGMP to Downregulate the TLR4-NF-[kappa]B-NLRP3 Inflammasome Signaling Pathway

Author

Aydin, Pelin, Magden, Zeynep Berna Aksakalli, Uzuncakmak, Sevgi Karabulut, Halici, Hamza, Akgun, Nurullah, Mendil, Ali Sefa, and Mokhtare, Behzad

Subjects
Ataturk University, Health aspects, Vardenafil -- Health aspects, Respiratory system agents -- Health aspects, Medical research -- Health aspects, Avanafil -- Health aspects, Adult respiratory distress syndrome -- Health aspects, RNA -- Health aspects, Medicine, Experimental -- Health aspects, Respiratory agents -- Health aspects, Acute respiratory distress syndrome -- Health aspects
Abstract

Author(s): Pelin Aydin [sup.1] [sup.2], Zeynep Berna Aksakalli Magden [sup.2], Sevgi Karabulut Uzuncakmak [sup.3], Hamza Halici [sup.2] [sup.4], Nurullah Akgun [sup.2], Ali Sefa Mendil [sup.5], Behzad Mokhtare [sup.6], Elif Cadirci [...], Aim We demonstrate the effect of PDE5 inhibitors in cases of acute lung injury via the relationship between cGMP/NO and the TLR4-NF-[kappa]B-NLRP3 pathway. Materials and Methods This study was performed with 30 male Wistar albino rats. Lipopolysaccharide (LPS) was administered intratracheally to the rats and acute lung injury (ALI) was induced. Twelve hours after LPS administration, avanafil, prepared at suitable doses according to the body weights of the animals, was administered by oral gavage. Lung tissue samples of all groups were examined histopathologically and by immunochemical staining (IL-1[beta], iNOS, TLR4, and NF-[kappa]B). The iNOS, NLRP3, and IL-1B mRNA expression levels in the lung tissues were measured by RT-PCR. The left upper lobes of the rat lungs were dried at 70 °C for 48 h and lung water content was calculated. Result Statistically significant increases in iNOS, NLRP3, and IL-1[beta] mRNA expressions were observed in the rats with ALI compared to the healthy controls (p < 0.0001). Those increased expressions were reduced at both doses of avanafil (p < 0.0001). This reduction was found to be greater at 20 mg/kg (p < 0.0001). IL-1[beta], iNOS, TLR4, and NF-[kappa]B immunopositivity was moderate/severe in the ALI group and mild in the group with ALI + avanafil at 20 mg/kg (p < 0.05). When the wet/dry lung ratios were calculated, a statistically significant increase was seen in the ALI group compared to the healthy rats (p < 0.05). That increase was decreased with both avanafil doses (p < 0.05). Conclusion We suggest that avanafil may prevent the progression of ALI and be effective in its treatment. We hope that this study will be supported by future clinical studies to yield a new indication for avanafil.

Published
2022
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43. COVID-19 drugs: Are there any that work?

Subjects
United States. Food and Drug Administration, Health aspects, Baricitinib -- Health aspects, Respiratory system agents -- Health aspects, Anakinra -- Health aspects, COVID-19 -- Health aspects, Respiratory agents -- Health aspects
Abstract

Answer Section COVID-19 medicine can help people who are at risk of, diagnosed with, or have symptoms of coronavirus disease 2019 (COVID-19). The medicine helps manage symptoms, stop the virus [...]

Published
2024

44. COVID-19 drugs: Are there any that work?

Subjects
United States. Food and Drug Administration, Health aspects, Baricitinib -- Health aspects, Respiratory system agents -- Health aspects, Anakinra -- Health aspects, COVID-19 -- Health aspects, Respiratory agents -- Health aspects
Abstract

Answer Section COVID-19 medicine can help people who are at risk of, diagnosed with, or have symptoms of coronavirus disease 2019 (COVID-19). The medicine helps manage symptoms, stop the virus [...]

Published
2024

45. COVID-19 drugs: Are there any that work?

Subjects
United States. Food and Drug Administration, Health aspects, Baricitinib -- Health aspects, Respiratory system agents -- Health aspects, Anakinra -- Health aspects, COVID-19 -- Health aspects, Respiratory agents -- Health aspects
Abstract

Answer Section COVID-19 medicine can help people who are at risk of, diagnosed with, or have symptoms of coronavirus disease 2019 (COVID-19). The medicine helps manage symptoms, stop the virus [...]

Published
2024

46. Occupational asthma

Subjects
United States. Occupational Safety and Health Administration, Health aspects, Respiratory system agents -- Health aspects, Asthma -- Health aspects, Respiratory agents -- Health aspects
Abstract

Overview Occupational asthma is a type of asthma caused by breathing in fumes, gases, dust or other substances while on the job. These substances can trigger an immune system response [...]

Published
2024

47. Occupational asthma

Subjects
United States. Occupational Safety and Health Administration, Health aspects, Respiratory system agents -- Health aspects, Asthma -- Health aspects, Respiratory agents -- Health aspects
Abstract

Overview Occupational asthma is a type of asthma caused by breathing in fumes, gases, dust or other substances while on the job. These substances can trigger an immune system response [...]

Published
2024

48. Occupational asthma

Subjects
United States. Occupational Safety and Health Administration, Health aspects, Respiratory system agents -- Health aspects, Asthma -- Health aspects, Respiratory agents -- Health aspects
Abstract

Overview Occupational asthma is a type of asthma caused by breathing in fumes, gases, dust or other substances while on the job. These substances can trigger an immune system response [...]

Published
2024

49. COVID-19 drugs: Are there any that work?

Subjects
United States. Food and Drug Administration, Health aspects, Baricitinib -- Health aspects, Respiratory system agents -- Health aspects, Anakinra -- Health aspects, COVID-19 -- Health aspects, Respiratory agents -- Health aspects
Abstract

Answer Section COVID-19 medicine can help people who are at risk of, diagnosed with, or have symptoms of coronavirus disease 2019 (COVID-19). The medicine helps manage symptoms, stop the virus [...]

Published
2024

50. Occupational asthma

Subjects
United States. Occupational Safety and Health Administration, Health aspects, Respiratory system agents -- Health aspects, Asthma -- Health aspects, Respiratory agents -- Health aspects
Abstract

Overview Occupational asthma is a type of asthma caused by breathing in fumes, gases, dust or other substances while on the job. These substances can trigger an immune system response [...]

Published
2024

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