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Background: We aimed to evaluate the effectiveness of the combination of protein supplementation and resistance training (RT), compared with RT alone or combined with a placebo, in improving gait speed. Methods: We searched PubMed, Web of Science, Cochrane Library, and SPORTDiscus databases, and 18 randomized controlled trials with 1,147 older participants were included for meta-analysis. Data were pooled as the effect sizes (Hedges' g) with 95% confidence interval (CI) of the gait speed (in meters per second). The random-effect meta-analysis, subgroup analyses, meta-regression, and sensitivity analysis were conducted. Results: The combination of protein supplementation and RT significantly improved gait speed (Hedges' g: 0.52 m/s, 95% confidence interval [0.17, 0.86], p =.005; I2 = 86.5%) compared with the RT alone. The subgroup analyses revealed that the significant improvement in gait speed postprotein intervention plus RT was observed only in participants who consumed protein after RT (Hedges' g: 0.90 m/s, 95% confidence interval [0.46, 1.33], p =.001; I2 = 79.6%). The pooled result did not significantly change after excluding any single study at one time or excluding smaller studies with large effect sizes. Conclusions: Protein supplementation combined with RT could significantly improve the gait speed of older adults compared with RT alone. This positive effect is more pronounced in people who consume protein after RT. [ABSTRACT FROM AUTHOR]

This case study assessed body composition, muscle strength, cardiorespiratory fitness, and metabolic health of the present female world champion powerlifter in the 70+ age category who started resistance exercise training at 63 years of age with no prior experience with structured exercise training. Measures of body composition (magnetic resonance imaging, computed tomography, and dual-energy X-ray absorptiometry scanning, leg volume); strength (one-repetition maximum leg press and extension, maximum voluntary contraction, and handgrip strength); physical function (short physical performance battery); cardiorespiratory fitness (peak oxygen consumption); and metabolic health (oral glucose tolerance test) were assessed. In addition, a muscle biopsy was collected to assess muscle fiber type distribution and cross-sectional area (CSA). Where possible, data were compared with previously (un)published sex- and age-matched data using z scores. Skeletal muscle mass index was calculated by dividing limb muscle mass by height squared. Data from the control groups are expressed as mean ± 95% confidence interval. Our participant (age: 71 years; body mass: 64.5 kg; body mass index: 27.6 kg/m2) reported a good bone mineral density of 1.09 g/cm2 (T score between −1 and +1) and very low values of abdominal and organ body fat (i.e., between 20% and 70% lower compared with a reference group of postmenopausal women). In addition, she showed a 33% greater skeletal muscle mass index when compared with healthy, older female control subjects (7.9 vs. 5.9 [5.7–6.2] kg/m2; n = 61) as well as 37% greater muscle quadriceps CSA (63.8 vs. 46.6 [44.5–48.7] cm2; n = 48) and 46% greater Type II muscle fiber CSA (4,536 vs. 3,097 [2,707–3,488] μm2; n = 19). Absolute leg press muscle strength was 36% greater (190 vs. 140 [132–147] kg; n = 30) and handgrip strength was 33% greater (33 vs. 25 [23–26] kg; n = 48) when compared with healthy, age-matched controls. In conclusion, even for resistance exercise naïve individuals, starting exercise at an advanced age can lead to improvements in body composition and muscle strength allowing older adults to reduce the risk for developing metabolic syndrome, live independently, and even compete at a world class level. [ABSTRACT FROM AUTHOR]

Whey protein ingestion during recovery from exercise increases myofibrillar but not muscle connective protein synthesis rates. It has been speculated that whey protein does not provide sufficient glycine to maximize postexercise muscle connective protein synthesis rates. In the present study, we assessed the impact of coingesting different amounts of collagen with whey protein as a nutritional strategy to increase plasma glycine availability during recovery from exercise. In a randomized, double-blind, crossover design, 14 recreationally active men (age: 26 ± 5 years; body mass index: 23.8 ± 2.1 kg·m−2) ingested in total 30 g protein, provided as whey protein with 0 g (WHEY), 5 g (WC05); 10 g (WC10), and 15 g (WC15) of collagen protein immediately after a single bout of resistance exercise. Blood samples were collected frequently over 6 hr of postexercise recovery to assess postprandial plasma amino acid kinetics and availability. Protein ingestion strongly increased plasma amino acid concentrations (p <.001) with no differences in plasma total amino acid availability between treatments (p >.05). The postprandial rise in plasma leucine and essential amino acid availability was greater in WHEY compared with the WC10 and WC15 treatments (p <.05). Plasma glycine and nonessential amino acid concentrations declined following whey protein ingestion but increased following collagen coingestion (p <.05). Postprandial plasma glycine availability averaged −8.9 ± 5.8, 9.2 ± 3.7, 23.1 ± 6.5, and 39.8 ± 11.0 mmol·360 min/L in WHEY, WC05, WC10, and WC15, respectively (incremental area under curve values, p <.05). Coingestion of a small amount of collagen (5 g) with whey protein (25 g) is sufficient to prevent the decline in plasma glycine availability during recovery from lower body resistance-type exercise in recreationally active men. [ABSTRACT FROM AUTHOR]

A comprehensive recent study by Trommelen et al. demonstrated that muscle tissue exhibits a greater capacity to incorporate exogenous exogenous protein-derived amino acids into bound muscle protein than was previously appreciated, at least when measured in "anabolically sensitive," recreationally active (but not resistance-trained), young men following resistance exercise. Moreover, this study demonstrated that the duration of the postprandial period is modulated by the dose of ingested protein contained within a meal, that is, the postexercise muscle protein synthesis response to protein ingestion was more prolonged in 100PRO than 25PRO. Both observations represent important scientific advances in the field of protein metabolism. However, we respectfully caution that the practical implications of these findings may have been misinterpreted, at least in terms of dismissing the concept of protein meal distribution as an important factor in optimizing muscle tissue anabolism and/or metabolic health. Moreover, based on emerging evidence, this idea that the anabolic response to protein ingestion has no upper limit does not appear to translate to resistance-trained young women. [ABSTRACT FROM AUTHOR]

Physical activity is an effective, proactive intervention to reduce or reverse frailty and functional decline. However, uncertainty exists about the feasibility and impact of resistance training on multidimensional health in prefrail older adults in residential care. This mixed methods feasibility study assessed practicability with limited efficacy testing on health and functional outcomes. Eleven prefrail older adults participated in a 6-week progressive resistance training protocol three times per week. The intervention and measures were found to be appropriate and acceptable by those who completed the trial, with participants self-reporting improved well-being, mood, and function. Analysis identified several barriers to recruitment, including prior commitments, seasonal impact, and session timing, and offered potential solutions with further recommendations for program refinement prior to a definitive randomized controlled trial. These findings add to our understanding of prefrail older adults' preferences regarding participation in physical activity research and the perceived benefits of resistance training. This trial was registered with ClinicalTrials.gov: NCT03141879. [ABSTRACT FROM AUTHOR]

Exercise-induced muscle adaptations vary based on exercise modality and intensity. We constructed a signalling network model from 87 published studies of human or rodent skeletal muscle cell responses to endurance or resistance exercise in vivo or simulated exercise in vitro. The network comprises 259 signalling interactions between 120 nodes, representing eight membrane receptors and eight canonical signalling pathways regulating 14 transcriptional regulators, 28 target genes and 12 exercise-induced phenotypes. Using this network, we formulated a logic-based ordinary differential equation model predicting time-dependent molecular and phenotypic alterations following acute endurance and resistance exercises. Compared with nine independent studies, the model accurately predicted 18/21 (85%) acute responses to resistance exercise and 12/16 (75%) acute responses to endurance exercise. Detailed sensitivity analysis of differential phenotypic responses to resistance and endurance training showed that, in the model, exercise regulates cell growth and protein synthesis primarily by signalling via mechanistic target of rapamycin, which is activated by Akt and inhibited in endurance exercise by AMP-activated protein kinase. Endurance exercise preferentially activates inflammation via reactive oxygen species and nuclear factor κB signalling. Furthermore, the expected preferential activation of mitochondrial biogenesis by endurance exercise was counterbalanced in the model by protein kinase C in response to resistance training. This model provides a new tool for investigating cross-talk between skeletal muscle signalling pathways activated by endurance and resistance exercise, and the mechanisms of interactions such as the interference effects of endurance training on resistance exercise outcomes.

OBJECTIVE: Exercise intervention is one of the main treatments for fibromyalgia, but there is no consistent conclusion on the choice of different exercise modalities. In this article, a network Meta-analysis was used to comprehensively and quantitatively evaluate the effects of different exercise modalities on fibromyalgia syndrome. METHODS: PubMed, EMbase, Scoups, The Cochrane Library, Web of Science, CNKI, WanFang Database, and China Biomedical Literature Database were searched for relevant literature, with a search timeframe from the establishment of each database to June 2023. The outcome indicators included five continuous variables, including fibromyalgia impact questionnaire-revised (FIQ) scores, visual analogue scale (VAS) scores, quality of life, quality of sleep, and depression. The Cochrane Risk of Bias Assessment Tool was used to evaluate the quality of the included literature. RevMan 5.4 software was used to perform effect sizes, subgroup analyses, and sensitivity analyses of the data. Stata 17 software was used to perform reticulation and network Meta-analysis of the data. RESULTS: A total of 13 articles with 14 randomized controlled trials were finally included. The overall methodological quality of the literature was high. The results of traditional Meta-analysis showed that, compared with the control group, exercise therapy significantly improved the FIQ score [standardized mean difference (SMD)=-0.67, 95% confidence interval (CI): -0.83 to -0.50, P < 0.01], VAS score (SMD=-0.72, 95% CI:-0.90 to -0.54, P < 0.01), quality of life (SMD=1.03, 95% CI: 0.45 to 1.61, P=0.000 5), sleep quality (SMD=-0.62, 95% CI: -0.98 to -0.25, P=0.001), and depression (SMD=-0.63, 95% CI: -1.09 to -0.18, P=0.007). Network Meta-analysis showed that the probability of optimal intervention effect of exercise modalities on FIQ scores was ranked as: mind-body exercise (86.5) > resistance exercise (70.5) > aerobic exercise (41.7); the probability of optimal intervention effect of exercise modalities on VAS scores was ranked as: resistance exercise (85.3) > mind-body exercise (74.3) > aerobic exercise (34.5). CONCLUSION: Exercise therapy significantly improves FIQ scores, VAS scores, quality of life, sleep quality, and depression in patients with fibromyalgia syndrome. Mind-body exercise and resistance exercise are the most effective exercise modalities to reduce FIQ scores and VAS scores in patients with fibromyalgia syndrome. [ABSTRACT FROM AUTHOR]

• A single bout of exercise is likely to induce small to large increases in myokine expression immediately after and up to 60 min post-exercise, while myokine responses typically revert to baseline levels from 180 min to 24 h post-exercise. • Both aerobic exercise and resistance exercise lead to notable changes in the expression of myokines; however, the magnitude of these changes varies according to the specific myokine type. • This meta-analysis expands our knowledge of the overall effects of myokine expression in relation to exercise modes; however, substantial variation is evident, indicating that the response to exercise mode is myokine-specific. • Some exercise modes and time points have not been investigated for certain myokines and, thus, should be considered for future research. The benefits of exercise are well known; however, many of the underlying molecular mechanisms are not fully understood. Skeletal muscle secretes myokines, which mediate muscle–organ crosstalk. Myokines regulate satellite-cell proliferation and migration, inflammatory cascade, insulin secretion, angiogenesis, fatty oxidation, and cancer suppression. To date, the effects of different exercise modes (namely, aerobic and resistance exercise) on myokine response remain to be elucidated. This is crucial considering the clinical implementation of exercise to enhance general health and wellbeing and as a medical treatment. A systematic search was undertaken in PubMed, MEDLINE, CINAHL, Embase, SPORTDiscus, and Web of Science in April 2023. Eligible studies examining the effects of a single bout of exercise on interleukin15 (IL-15), irisin, secreted protein acidic and rich in cysteine (SPARC), oncostatin M (OSM), and decorin were included. A random-effects meta-analysis was also undertaken to quantify the magnitude of change. Sixty-two studies were included (n = 1193). Overall, exercise appeared to induce small to large increases in myokine expression, with effects observed immediately after to 60 min post-exercise, although these were mostly not statistically significant. Both aerobic and resistance exercise resulted in changes in myokine levels, without any significant difference between training modes, and with the magnitude of change differing across myokines. Myokine levels returned to baseline levels within 180 min to 24 h post-exercise. However, owing to potential sources of heterogeneity, most changes were not statistically significant, indicating that precise conclusions cannot be drawn. Knowledge is limited but expanding with respect to the impact of overall and specific effects of exercise on myokine expression at different time points in the systemic circulation. Further research is required to investigate the effects of different exercise modes at multiple time points on myokine response. [Display omitted] [ABSTRACT FROM AUTHOR]

Purpose: To monitor changes in mood, cognitive function, brain electrical activity, and circulating kynurenine pathway metabolites in response to a 3-wk severe physical activity (PA) restriction, followed by 3 wk of resumed activity adding resistance and high-intensity interval exercise training. Methods: Twenty healthy participants (14 males, 6 females; 25.4 ± 5.2 yr) underwent 3 wk of limited PA using forearm crutches with one leg suspended (INACT) and then 3 wk of resumed activity plus supervised resistance and high-intensity interval training sessions (ACT, three to six sessions per week). At baseline, after INACT, and then after ACT, venous blood was sampled for analysis of major kynurenine pathway metabolites, a short version of the International Physical Activity Questionnaire, Hospital Anxiety and Depression Scale (HADS) and Profile of Mood States (POMS) questionnaires were completed, and cognitive tests with electroencephalography were performed. Results: During INACT, the depression score on the HADS scale tended to increase (3.5 to 6.8; P = 0.065), whereas it was reduced with ACT compared with after INACT (2.8; P = 0.022). On the POMS scale, depression, fatigue, and confusion increased within INACT (P < 0.05). Notably, subjects exhibited considerable variability, and those experiencing depression symptoms recorded by the HADS scale (n = 4) displayed distinct mood disturbances on POMS. All HADS and POMS scores were fully restored to baseline with ACT. Neither INACT nor ACT induced significant changes in cognition, brain electrical activity, or kynurenine pathway metabolites (P > 0.05). Conclusions: Although young healthy individuals with 3 wk of severely restricted PA do not undergo changes in circulating kynurenine pathway metabolites, cognitive performance, and brain electrical activity, their mood response is quite variable, and depression develops in some. Three weeks of resuming mobility plus exercise training reversed the mood profile. [ABSTRACT FROM AUTHOR]

Purpose: Autophagy and heat shock protein (HSP) response are proteostatic systems involved in the acute and adaptive responses to exercise. These systems may upregulate sequentially following cellular stress including acute exercise, however, currently few data exist in humans. This study investigated the autophagic and HSP responses to acute intense lower body resistance exercise in peripheral blood mononuclear cells (PBMCs) with and without branched-chain amino acids (BCAA) supplementation. Methods: Twenty resistance-trained males (22.3 ± 1.5 yr; 175.4 ±.7 cm; 86.4 ± 15.6 kg) performed a bout of intense lower body resistance exercise and markers of autophagy and HSP70 were measured immediately post- (IPE) and 2, 4, 24, 48, and 72 h post-exercise. Prior to resistance exercise, 10 subjects were randomly assigned to BCAA supplementation of 0.22 g/kg/d for 5 days pre-exercise and up to 72 h following exercise while the other 10 subjects consumed a placebo (PLCB). Results: There were no difference in autophagy markers or HSP70 expression between BCAA and PLCB groups. LC3II protein expression was significantly lower 2 and 4 h post-exercise compared to pre-exercise. LC3II: I ratio was not different at any time point compared to pre-exercise. Protein expression of p62 was lower IPE, 2, and 4 h post-exercise and elevated 24 h post-exercise. HSP70 expression was elevated 48 and 72 h post-exercise. Conclusions: Autophagy and HSP70 are upregulated in PBMCs following intense resistance exercise with autophagy increasing initially post-exercise and HSP response in the latter period. Moreover, BCAA supplementation did not affect this response. [ABSTRACT FROM AUTHOR]

Purpose: To explore if mean concentric velocity (MCV) of the last repetition before set failure differs between free-weight back squat protocols with greater emphasis on metabolic accumulation vs. mechanical loading. The between-set and between-day reliability of terminal MCV obtained with these different loading schemes was also determined. Methods: Fifteen healthy male participants (18–30 years) were included. They all were required to exhibit a relative strength ≥ 1.5 times their body mass. MCVs were obtained at one-repetition maximum (1RM) and with two submaximal protocols (metabolic emphasis: three sets of 40%1RM with blood-flow restriction vs. mechanical emphasis: three sets 80%1RM without blood-flow restriction). Participants were instructed to reach maximal intended concentric velocity in each repetition up to failure. Results: Set failure was achieved at a faster MCV with the metabolic protocol (p < 0.05). The reliability of MCV at failure reached higher values for the metabolic loading scheme. However, while the MCV achieved at failure during the metabolic protocol was systematically higher than the MCV at 1RM (p < 0.05), this was not entirely the case for the mechanical protocol (similar to 1RM MCV during the last sets in both testing days). Finally, the absolute error derived from estimating the MCV at 1RM based on the MCV obtained at set failure with the mechanical protocol was considerably high (≥ 0.05 m/s). Conclusion: This study indicates that MCV obtained at set failure is dependent on the specificity of the physiological demands of exercise. Thus, MCVs obtained at failure with submaximal loads should not be used to estimate 1RM MCV. [ABSTRACT FROM AUTHOR]

We compared the magnitude of exercise-induced hypoalgesia and conditioned pain modulation between blood-flow restriction (BFR) resistance exercise (RE) and moderate-intensity RE. Twenty-five asymptomatic participants performed unilateral leg press in two visits. For moderate-intensity RE, subjects exercised at 50% 1RM without BFR, whereas BFR RE exercised at 30% 1RM with a cuff inflated to 60% limb occlusion pressure. Exercise-induced hypoalgesia was quantified by pressure pain threshold changes before and after RE. Conditioned pain modulation was tested using cold water as the conditioning stimulus and mechanical pressure as the test stimulus and quantified as pressure pain threshold change. Difference in conditioned pain modulation pre- to post-RE was then calculated. The differences of RE on pain modulations were compared using paired t-tests. Pearson's r was used to examine the correlation between exercise-induced hypoalgesia and changes in conditioned pain modulation. We found greater hypoalgesia with BFR RE compared to moderate-intensity RE (p=0.008). Significant moderate correlations were found between exercise-induced hypoalgesia and changes in conditioned pain modulation (BFR: r=0.63, moderate-intensity: r=0.72). BFR RE has favorable effects on pain modulation in healthy adults and the magnitude of exercise-induced hypoalgesia is positively correlated with conditioned pain modulation activation. [ABSTRACT FROM AUTHOR]

We examined how resistance exercise (RE), cycling exercise and disuse atrophy affect myosin heavy chain (MyHC) protein fragmentation. The 1boutRE study involved younger men (n = 8; 5 ± 2 years of RE experience) performing a lower body RE bout with vastus lateralis (VL) biopsies being obtained prior to and acutely following exercise. With the 10weekRT study, VL biopsies were obtained in 36 younger adults before and 24 h after their first/naïve RE bout. Participants also engaged in 10 weeks of resistance training and donated VL biopsies before and 24 h after their last RE bout. VL biopsies were also examined in an acute cycling study (n = 7) and a study involving 2 weeks of leg immobilization (n = 20). In the 1boutRE study, fragmentation of all MyHC isoforms (MyHCTotal) increased 3 h post‐RE (∼200%, P = 0.018) and returned to pre‐exercise levels by 6 h post‐RE. Interestingly, a greater magnitude increase in MyHC type IIa versus I isoform fragmentation occurred 3 h post‐RE (8.6 ± 6.3‐fold vs. 2.1 ± 0.7‐fold, P = 0.018). In 10weekRT participants, the first/naïve and last RE bouts increased MyHCTotal fragmentation 24 h post‐RE (+65% and +36%, P < 0.001); however, the last RE bout response was attenuated compared to the first bout (P = 0.045). Although cycling exercise did not alter MyHCTotal fragmentation, ∼8% VL atrophy with 2 weeks of leg immobilization increased MyHCTotal fragmentation (∼108%, P < 0.001). Mechanistic C2C12 myotube experiments indicated that MyHCTotal fragmentation is likely due to calpain proteases. In summary, RE and disuse atrophy increase MyHC protein fragmentation. Research into how ageing and disease‐associated muscle atrophy affect these outcomes is needed. Highlights: What is the central question of this study?How different exercise stressors and disuse affect skeletal muscle myosin heavy chain fragmentation.What is the main finding and its importance?This investigation is the first to demonstrate that resistance exercise and disuse atrophy lead to skeletal muscle myosin heavy chain protein fragmentation in humans. Mechanistic in vitro experiments provide additional evidence that MyHC fragmentation occurs through calpain proteases. [ABSTRACT FROM AUTHOR]

Background: The prevalence of type 2 diabetes mellitus (T2DM) presents a challenge for health organizations because of its high likelihood of morbidity and mortality. There is an increasing body of evidence exploring the efficacy of resistance training (RT) alone on glycemic control. Objective: To update the effectiveness of RT on glycosylated hemoglobin (HbA1c) and fasting glucose in adults diagnosed with T2DM. Methods: CINAHL (EBSDCO), PubMed, MEDLINE (Ovid), and EMBASE (Ovid) databases were searched from inception to 30 January 2024. Published randomized controlled trials (RCTs) of adult humans with T2DM assessing the impact of RT on HbA1c and fasting glucose compared with control condition were included. Data were pooled by the inverse-variance method and reported as mean differences (MDs) with 95% confidence intervals (CIs). Results: Forty-six RCTs totaling 2130 participants met the inclusion criteria. Meta-analysis demonstrated RT significantly reduced HbA1c (MD -0.50% [95% CI, −0.67, −0.34 %], p <.00,001) and fasting glucose (MD -12.03 mg/dl [95% CI, −19.36, −4.69 mg/dl], p =.001). Subgroup analyses found that exercise training durations, gender, and risk of bias had statistically significant effects on HbA1c levels and fasting glucose concentrations after resistance training. However, meta-regression analyses revealed that variables including year of publication, number of sessions per week, mean sample age, sample size, and study quality scores did not significantly affect the change in either HbA1c or glucose. Conclusion: Our meta-analysis with meta-regression delivers further evidence that RT programs are effective approach in attenuation of HbA1c and fasting glucose in individuals with T2DM. [ABSTRACT FROM AUTHOR]

We evaluated the effects of post-activation performance enhancement through flywheel exercise with varying inertial loads compared to traditional resistance exercise on countermovement jump performance and muscle recruitment. In a randomized crossover design, 13 trained men completed four main experimental trials after three familiarization sessions. These conditions included a traditional trial consisting of 5 sets of 1 repetition using the Smith machine (SM) squat at 90% 1RM, and three flywheel ergometer trials. Each flywheel protocol consisted of 3 sets of 8 repetitions with 3-minute rest intervals between sets, utilizing one of three inertial loads (0.0465, 0.0784, and 0.1568 kg · m2 for light, moderate, and heavy, respectively). Participants performed countermovement jumps before (baseline), immediately after (0 minute), and at the fourth (+4 minutes), eighth (+8 minutes), and twelfth (+12 minutes) minute following exercise. Compared to baseline, jump height was higher at +4 minutes for SM squats (p = 0.009). All flywheel conditions exhibited higher jump heights at +4 minutes (p < 0.05), +8 minutes (p < 0.001), and +12 minutes (p < 0.001) compared to baseline. Additionally, moderate and heavy loads resulted in higher jump heights at 0 minute (both p < 0.001). Integrated electromyographic activity values, a proxy for muscle recruitment, were significantly higher for the gluteus maximus muscle at both +8 minutes and +12 minutes for moderate (both p = 0.004) and heavy loads (p ≤ 0.002) compared to SM squats. Overall, flywheel protocols produce greater post-activation performance enhancement, extend the time window for improvement, and recruit more active musculature compared to heavy-load SM squats, particularly with heavier loads acting as a stronger preload stimulus. [ABSTRACT FROM AUTHOR]

Intermittent palm (PC) and sole cooling (SC) are proposed ergogenic methods for enhancing exercise performance during high-intensity and fatiguing conditions. However, findings in the literature regarding its positive effect remain inconclusive. This study aimed at investigating the effects of intermittent PC and SC compared to no cooling (NC) on acute training volume during resistance exercise, particularly focusing on the total number of repetitions (TR) performed. Three separate randomized crossover protocols, incorporating commonly practiced resistance exercises (Protocol 1: pullups; Protocol 2: pushups; Protocol 3: leg extensions), were conducted, enrolling healthy, physically active adults (overall sample: n = 41 (12 female), age: 23.9 ± 4.0 years (mean ± SD), height: 174.4 ± 9.5 cm, body mass: 69.3 ± 12.4 kg). During Protocol 3, tympanic temperature (TT), rate of perceived exertion (RPE), and electromyography (EMG) of quadriceps muscles were additionally assessed for SC. PC resulted in less TR compared to NC in Protocol 1 (p < 0.001). Protocol 2 and 3 did not reveal significant ergogenic benefits of PC or SC compared to NC (p > 0.05). Furthermore, SC had no effect on TT, RPE, or EMG amplitudes (all p > 0.05). The inconsistent findings suggest that intermittent PC and SC might have limited effectiveness in enhancing training volume during resistance exercise in physically active adults. Future research should examine various resistance training protocols under controlled conditions, and incorporate comprehensive physiological measurements to elucidate the potential benefits and mechanisms of intermittent cooling in resistance exercise contexts. [ABSTRACT FROM AUTHOR]

BACKGROUND: Sarcopenia is an age-related degenerative syndrome, and the relationship between mitochondrial autophagy and exercise in preventing and treating sarcopenia has been demonstrated. However, there is a lack of comprehensive reviews detailing the specific receptor proteins and signaling pathways involved in the role of exercise in sarcopenia prevention and treatment. OBJECTIVE: To comprehensively introduce the specific receptor proteins and signaling pathways related to mitochondrial autophagy and their role in the prevention and treatment of sarcopenia through exercise. METHODS: A literature search was conducted between February 1, 2023, and April 1, 2023, covering literature from database inception to April 2023. Databases included the Web of Science, PubMed, China National Knowledge Infrastructure (CNKI), WanFang Data, and VIP. Keywords used for the search included sarcopenia, muscle wasting, aging, elderly, mitochondria, mitochondrial function, proteins, pathways, and others. After strict inclusion and exclusion criteria, 76 articles were ultimately included. RESULTS AND CONCLUSION: Sarcopenia is a disease characterized by a decline in muscle mass and function with age, and its pathogenesis involves neuromuscular functional decline, chronic inflammation, acid-base imbalance, and mitochondrial dysfunction. Mitochondrial autophagy is an important process for clearing damaged mitochondria in cells, in which receptor proteins and signaling pathways are involved in the regulation of mitochondrial autophagy. Exercise can promote the occurrence of mitochondrial autophagy by regulating the activity of these receptor proteins and signaling pathways, thereby playing an important role in the prevention and treatment of sarcopenia. Exercise can induce mitochondrial autophagy in sarcopenia by upregulating AMPK, phosphorylating ULK1, and reducing mitochondrial energy, enhancing the expression of mitochondrial autophagy-related proteins associated with AMBRA1, and regulating the PINK1/Parkin pathway, to improve mitochondrial dysfunction caused by sarcopenia. In addition, exercise can activate the mTOR pathway to promote muscle growth and increase glucose uptake, thereby preventing and treating sarcopenia. Future studies are needed to further investigate the specific mechanisms and regulatory pathways of mitochondrial autophagy-related receptor proteins and signaling pathways in the prevention and treatment of sarcopenia by exercise, and to conduct more clinical trials in humans, thereby to promote further development in this field. [ABSTRACT FROM AUTHOR]

Multiple sclerosis (MS) is a chronic autoimmune disease characterized by inflammation and demyelination in the central nervous system (CNS) with subsequent axonal and neuronal degeneration. These changes are associated with a broad range of symptoms including skeletal muscle dysfunction. Importantly, musculoskeletal impairments manifest in various ways, compromise the quality of life and often precede the later development of mobility disability. As current standard disease modifying therapies for MS predominantly act on neuroinflammation, practitioners and patients face an unmet medical need for adjunct therapies specifically targeting skeletal muscle function. This review is intended to detail the nature of the skeletal muscle dysfunctions common in people with MS (pwMS), describe underlying intramuscular alterations and outline evidence-based therapeutic approaches. Particularly, we discuss the emerging role of aerobic and resistance exercise for reducing the perception of fatigue and increasing muscle strength in pwMS. By integrating the most recent literature, we conclude that both exercise interventions should ideally be implemented as early as possible as they can address MS-specific muscle impairments. Aerobic exercise is particularly beneficial for pwMS suffering from fatigue and metabolic impairments, while resistance training efficiently counters muscle weakness and improves the perception of fatigue. Thus, these lifestyle interventions or possible pharmacological mimetics have the potential for improving the general well-being and delaying the functional declines that are relevant to mobility. [ABSTRACT FROM AUTHOR]

During unilateral static and rhythmic handgrip exercise, middle cerebral artery blood velocity (MCAv) increases in the contralateral side to the exercising limb. However, whether this neurovascular coupling‐mediated increase in contralateral MCAv is apparent against a background of fluctuating perfusion pressure produced by dynamic resistance exercise (RE) is unclear. We examined the cerebral haemodynamic response to unilateral dynamic RE in 30 healthy individuals (female = 16, mean ± SD: age, 26 ± 6 years; height, 175 ± 10 cm; weight, 74 ± 15 kg; body mass index, 24 ± 5 kg m−2). Participants completed four sets of 10 paced repetitions (15 repetitions min−1) of unilateral bicep curl exercise at 60% of the predicted one‐repetition maximum (7 ± 3 kg). Beat‐to‐beat blood pressure, bilateral MCAv and end‐tidal carbon dioxide were measured throughout. One‐way ANOVA was used to analyse cardiovascular variables and two‐way ANOVA to analyse dependent cerebrovascular variables (side × sets, 2 × 5). A linear mixed model analysis was also performed to investigate the effects of end‐tidal carbon dioxide and mean arterial blood pressure on MCAv. In comparison to baseline, within‐exercise mean arterial blood pressure increased (P < 0.001) across the sets, whereas bilateral MCAv decreased (P < 0.001). However, no significant interaction effect was observed for any dependent variables (all P > 0.787). The linear mixed model revealed that end‐tidal carbon dioxide had the greatest effect on MCAv (estimate = 1.019, t = 8.490, P < 0.001). No differences were seen in contralateral and ipsilateral MCAv during dynamic RE, suggesting that neurovascular coupling contributions during dynamic RE might be masked by other regulators, such as blood pressure. [ABSTRACT FROM AUTHOR]

Resistance exercise and protein supplementation are recognized as effective treatment strategies for age-related sarcopenia; however, there are limited data on their feasibility, tolerability, and safety. The primary outcome of this study was feasibility, evaluated through the 15-item TELOS (Technological, Economics, Legal, Operational, and Scheduling) feasibility components and by recruitment, retention, and consent rates. Tolerability was measured by examining permanent treatment discontinuation, treatment interruption, exercise dose modification, early termination, rescheduling of missed sessions, losses to follow-up, attendance, and nutritional compliance. Safety was evaluated using the parameters provided by the European Medicines Agency, adapted for exercise interventions. Thirty-two subjects were recruited (average age 81.6 [SD 9.3] years). The TELOS components were assessed before the intervention; out of 15 questions relevant for successful implementation, 4 operational needs answers required specific actions to prevent potential barriers. The recruitment rate was 74%. Eleven patients (34.4%) had permanent treatment interruption (retention rate = 65.6%). Patients attended a mean of 23 (SD 12.0) exercise sessions, with a mean of 56 (SD 32.6) nutritional compliances. A total of 21 patients (65.6%) experienced adverse events unrelated to the intervention, while 7 patients (21.9%) presented adverse reactions to strength exercise. The main barriers to feasibility were operational components and recruitment challenges. Although the intervention was generally safe, the high rate of probable adverse effects, unrelated to the intervention but associated with the individual's baseline health condition, may affect adherence to treatment programs of this kind. [ABSTRACT FROM AUTHOR]

Background: The study evaluated the effects of resistance exercise training and açaí supplementation on cardiac parameters in hypertensive animals. Methods: For this study, rats from the Wistar and SHR lines (spontaneously hypertensive rats) were used. The animals were divided into 5 groups: Wistar Control (C); Control Hypertensive (H); Trained Hypertensive (HT); Hypertensive and Supplemented with Açaí (HA); and Hypertensive Trained and Supplemented with Açaí (HAT). Resistance exercise training was carried out through climbing. The supplemented groups received 3 g of açaí/kg of body mass. The animals' systolic blood pressure (SBP), body mass, and physical test were measured at the beginning and end of the intervention. At the end, an echocardiographic analysis was performed. Histological analysis and oxidative stress of the LV were performed. Results: It was found that hypertensive animals showed an increase in SBP, and the treatments reduced this parameter. The trained groups achieved higher values of maximum carrying load. Hypertension increased the dimension of the left ventricular free wall in diastole and reduced ejection and shortening fractions. The trained groups showed improvement in ejection and shortening fractions. The H group increased the proportion of extracellular matrix and reduced the proportion of cells, with the HAT group attenuating this change. Cell diameter was greater in group H, and all treatments reduced this parameter. Hypertension increased the concentration of malondialdehyde and decreased catalase activity in LV. The treatments managed to mitigate this damage. Conclusions: It is concluded that the treatments managed to generate positive cardiovascular adaptations, and their combination enhanced these effects. [ABSTRACT FROM AUTHOR]

Introduction: Sarcopenia is common in children after liver transplantation (LTx). Resistance training (RT) may be effective in combating sarcopenia. Objectives: The purpose of the study was to test the feasibility and impact of a 12‐week RT program on skeletal muscle mass (SMM), muscle strength, physical performance (PP), and child–parent perspectives about RT. Methods: Children (6–18 years) post‐LTx and healthy controls (HC) underwent progressive RT using resistance bands. SMM and adipose tissue (MRI: abdomen and thigh), muscle strength (handgrip, push‐ups, sit‐to‐stand), and PP (6‐minute walk test [6MWT], timed‐up‐and‐down‐stair test [TUDS]) were measured before and after 12‐weeks of RT. Results: Ten children post‐LTx (11.9 ± 3.5 years) and 13 HC (11.7 ± 3.9 years) participated. LTx children significantly increased abdominal SM‐index (+4.6% LTx vs. a −2.7% HC; p = 0.01) and decreased visceral adipose tissue‐index (−18% LTx vs. −0.8% HC; p = 0.04) compared to HC. No thigh SMI changes were noted. Significant increases in 6MWT distance (LTx; p = 0.04), number of push‐ups (p = 0.04), and greater reduction times for TUDS (−10.6% vs. +1.7%; p = 0.05) occurred after 12 weeks. Higher thigh muscle‐fat content was associated with worse physical performance. These results were impacted by adherence (≥75% vs. <75%) and family engagement. Conclusions: RT in children post‐LTx is feasible and effective. RT in children post‐LTx may alleviate adverse outcomes associated with sarcopenia. [ABSTRACT FROM AUTHOR]

Mental fatigue can impair resistance exercise performance. Brain endurance training (BET)--the addition of demanding cognitive tasks to standard exercise training--improves endurance exercise performance more than standard training. Although BET has yet to be evaluated with resistance exercise, it is expected to improve performance, particularly when the performer feels mentally fatigued. The study employed a pretest (week 0), midtest (week 3), posttest (week 6), and follow-up (week 9) design, with subjects randomized to BET (n = 46) or control (exercise training) (n = 45) groups. In testing sessions, subjects performed chest press and squat jump exercises to failure before (feeling fresh) and after (feeling tired) a 30-minute cognitively demanding Stroop task. Training comprised 5 BET or control training sessions per week for 6 weeks. In each training session, subjects completed 4 sets of each exercise to failure, with each exercise set preceded by a 3-minute cognitive task (BET) or rest (control). Exercise performance (number of repetitions to failure) and mental fatigue markers were assessed. In pretesting, exercise performance did not differ between the groups. In midtesting and posttesting, BET performed more chest press and squat jump repetitions when fatigued by the 30-minute Stroop than control. The mental fatigue elicited by the Stroop task gradually declined with training in BET compared with control. In conclusion, BET enhanced resistance exercise performance compared with standard training when tested sub-sequent to a mentally fatiguing cognitive task. These benefits were maintained weeks after training ended. Brain endurance training is an effective method to mitigate the deleterious effects of mental fatigue on resistance exercise performance. [ABSTRACT FROM AUTHOR]

Introduction: Breast cancer patients (BCP) experience considerable side effects during and after treatment. Several studies have shown positive effects of exercise on therapy-related side-effects such as loss of muscle strength, loss of bone mineral density, lymphedema, and several elements of quality of life (QoL). Resistance exercise has proven effective and beneficial for BCP; however, optimal individual training parameters remain to be determined. Methods: The aim of our study was to implement an adaptive, progressive, supervised resistance protocol for BCPs during chemotherapy, improving muscle strength, physical condition, and overall QoL while reducing therapy-induced side-effects. Forty patients receiving adjuvant chemotherapy were included 6–12 weeks post-OP. Twenty patients underwent high intensity resistance-training twice a week for 12 weeks, and the control group received usual care. Results: Strength parameters improved significantly in the intervention group and in different scales of QoL. We documented a cyclic performance level dependent on the number of days after treatment. Conclusion: Adaptive resistance training with simple training control mechanisms proved to be effective regarding optimal intensity in each training session and needs to be implemented in further studies in order to guarantee adequate loads in accordance to the training protocols. [ABSTRACT FROM AUTHOR]

Physical exercise has demonstrated the potential to improve cognitive impairment in schizophrenia, although the results are limited. The objective of this meta-analysis is to synthesize the existing evidence on the impact of physical exercise on cognitive functions in schizophrenia. A systematic search of PubMed, Scopus, Web of Science, and Embase was conducted. The study included controlled clinical trials on patients with schizophrenia that received physical exercise as the intervention for improving cognition. A meta-analysis was conducted using a random-effects model, and the outcomes were reported using the standardized mean difference (SMD) and a 95 % confidence interval (95 % CI). A total of 22 articles, including 1066 patients (565 in the intervention group and 501 in the control group), were included in the final analysis. Physical exercises significantly improved global cognition (SMD: 0.73, 95 % CI (0.46–1.00), P < 0.001), and aerobic exercise was found to have a more significant effect than resistance and mindfulness exercise (SMD: 0.76, 95 % CI (0.45–1.07), P < 0.001). The speed of processing [SMD: 0.88, 95 % CI (0.37–1.38), P = 0.001], attention [SMD: 0.61, 95 % CI (0.20–1.02), P = 0.004], and visual learning memory [SMD: 1.42, 95 % CI (0.14–2.71), P = 0.03] demonstrated significant improvement after physical exercise, while no significant effects were observed on working memory, verbal learning memory, reasoning and problem-solving, and social cognition. Exercise can improve overall cognitive function in people with Schizophrenia. However, it is unclear whether this improvement is significant in specific cognitive domains. [ABSTRACT FROM AUTHOR]

Background: Skeletal muscle loss is prevalent throughout the cancer continuum and correlated with morbidity and mortality. Resistance exercise has been trialed to mitigate skeletal muscle loss. This systematic review summarizes and qualitatively synthesizes the effects of resistance exercise on muscle-related outcomes in adult cancer populations, including skeletal muscle mass, performance and muscle-related biomarkers. Methods: The systematic review protocol was developed in accordance with the Preferred Reporting Items for Systematic Review and Meta-Analysis Protocols (PRISMA-P). We searched electronic databases including AMED, CENTRAL, CINAHL, CIRRIE, EMBASE, MEDLINE, PEDro, REHABDATA, Scopus, and SPORTDiscus from inception to December 2021. We included randomized controlled trials that investigated the effects of resistance exercise on muscle-related outcomes in adult cancer populations. Interventions that involved any resistance exercise were included. Muscle-related outcomes were categorized as skeletal muscle mass (e.g., lean mass, appendicular muscle mass), muscle performance (e.g., muscle strength, physical function), and muscle-related biomarkers (e.g., muscle cells, metabolic/inflammatory markers). Risk of bias (RoB) was assessed using the Cochrane ROB tool. Results: A total of 102 studies from 101 randomized controlled trials were included. The majority of studies focused on breast cancer (46%) and those who completed treatment (43%). Resistance exercise interventions were largely 3-4 months long (48%), combined with aerobic exercise (56%), at a vigorous intensity (25%), and in-person/supervised settings (57%). Among the studies assessing muscle mass, performance, and biomarkers (n = 42, 83, and 22, respectively), resistance exercise interventions improved upper/lower body or appendicular muscle mass (67%-100%), muscle strength (61%-68%), and physical function (74%-100%). Most biomarkers did not show significant changes (75%-100%) or showed inconsistent results. Conclusions: Generally, resistance exercise had positive effects on skeletal muscle mass and performance with no negative effects compared to controls. Our findings demonstrated that resistance exercise may be an effective strategy to attenuate deterioration or exert improvements in muscle mass and performance outcomes. [ABSTRACT FROM AUTHOR]

Sleep disorders are prevalent among the general population and even more in individuals suffering from chronic diseases. Recent data reveal promising effects of physical exercise as a non-pharmacological approach for improving sleep and managing various sleep disorders. However, more studies with proper design and methodology should be conducted in the future to obtain a clearer understanding of the subject. The role of exercise in preventing and improving sleep disorders is probably much higher than what is currently exploited. To fully exploit the potential benefit of physical activity on sleep disorders in the future, it is necessary to identify the relevant tools to assess sleep–wake disorders and establish specific exercise protocols tailored to different sleep disorders. The present manuscript aims to review the literature on the use of exercise in managing selected sleep disorders. Regular exercise, including short-term aerobic activity, resistance training, and mind–body exercises, can effectively improve sleep quality, particularly in cases of insomnia and sleep-disordered breathing. Additionally, increasing evidence supports the effectiveness of aerobic and strength training, and body-mind exercises such as yoga in managing sleep-related movement disorders. Exercise can be a safe, affordable, and efficient tool in enhancing sleep quality and improving sleep disorders. Per se, regular exercise could play an adjuvant role alongside with established therapies, or a valid alternative when the pharmacological approach is limited by side effects, interactions, or inefficacy. More research is needed to define how exercise affects the physiology of sleep, and consequently how to use exercise in patients with sleep disorders. [ABSTRACT FROM AUTHOR]

Dynamic resistance exercise (RE) produces sinusoidal fluctuations in blood pressure with simultaneous fluctuations in middle cerebral artery blood velocity (MCAv). Some evidence indicates that RE may alter cerebrovascular function. This study aimed to examine the effects of habitual RE training on the within‐RE cerebrovascular responses. RE‐trained (n = 15, Female = 4) and healthy untrained individuals (n = 15, Female = 12) completed four sets of 10 paced repetitions (15 repetitions per minute) of unilateral leg extension exercise at 60% of predicted 1 repetition maximum. Beat‐to‐beat blood pressure, MCAv and end‐tidal carbon dioxide were measured throughout. Zenith, nadir and zenith‐to‐nadir difference in mean arterial blood pressure (MAP) and mean MCAv (MCAvmean) for each repetition were averaged across each set. Two‐way ANOVA was used to analyse dependent variables (training × sets), Bonferroni corrected t‐tests were used for post hoc pairwise comparisons. Group age (26 ± 7 trained vs. 25 ± 6 years untrained, P = 0.683) and weight (78 ± 15 vs. 71 ± 15 kg, P = 0.683) were not different. During exercise average MAP was greater for the RE‐trained group in sets 2, 3 and 4 (e.g., set 4: 101 ± 11 vs. 92 ± 7 mmHg for RE trained and untrained, respectively, post hoc tests all P = < 0.012). Zenith MAP and zenith‐to‐nadir MAP difference demonstrated a training effect (P < 0.039). Average MCAvmean and MCAvmean zenith‐to‐nadir difference was not different between groups (interaction effect P = 0.166 and P = 0.459, respectively). Despite RE‐trained individuals demonstrating greater fluctuations in MAP during RE compared to untrained, there were no differences in MCAvmean. Regular RE may lead to vascular adaptations that stabilise MCAv during RE. What is the central question of this study?Resistance exercise produces vascular adaptations within the central arteries: do these adaptations extend to the cerebral circulation? What are the effects of habitual resistance exercise training on the within‐resistance exercise cerebrovascular responses?What is the main finding and its importance?During dynamic resistance‐exercise, resistance‐trained individuals demonstrated greater mean arterial pressure, but mean middle cerebral artery blood velocity did not differ from untrained individuals, indicating improved cerebral blood flow regulation. These findings suggest that functional cerebrovascular adaptations may have occurred during repetitive exposure to fluctuations in blood pressure. [ABSTRACT FROM AUTHOR]

Background and Aim: Changes in corticospinal excitability will cause a change in the neural output and finally the maximum force will be changed. Various training and non-training factors affect this neuromuscular response and it seems that the intensity of the intervention is one of the effective factors in this regard. Based on this, the present study sought to investigate the response of corticospinal excitability to different intensities of postactivation potentiation in young trained subjects. Materials and Methods: Eight young men (24.8±2.70 year) performed the research protocol in three separate sessions with preparatory contractions during the handgrip movement with intensities of 20, 50 and 80% root mean square of maximal voluntary contraction. Several times after that, the amount of corticospinal excitability, the electrical activity of the flexor carpi radialis muscle (FCR) and the maximum force in the hangrip were measured with a dynamometer. Then, the results were extracted by using the statistical method of repeated-measures analysis of variance at a significance level of p<0.05. Results: The amplitude of motor evoked potential increased after preparatory contraction with intensity of 20%, but it decreased significantly after intensity of 50% and 80%; so that, there was no significant difference between the intensity of 50% and 80%. On the other hand, the amount of voluntary force measured by the maximum voluntary contraction did not show any significant change as well as the electrical activity immediately and after 5 minutes of preparatory contraction. Conclusion: None of the changes in corticospinal excitability were associated with changes in muscle strength and electrical activity. Therefore, there is a complex interaction between changes in supraspinal excitability following preparatory contractions and their effect on an individual's ability to improve or maintain force output, and further investigations are needed in this area. [ABSTRACT FROM AUTHOR]

Background: Exercise and dietary interventions are essential for maintaining weight and reducing fat accumulation. With the growing popularity of various dietary strategies, evidence suggests that combining exercise with dietary interventions offers greater benefits than either approach alone. Consequently, this combined strategy has become a preferred method for many individuals aiming to maintain health. Calorie restriction, 5/2 intermittent fasting, time-restricted feeding, and the ketogenic diet are among the most popular dietary interventions today. Aerobic exercise, resistance training, and mixed exercise are the most widely practiced forms of physical activity. Exploring the best combinations of these approaches to determine which yields the most effective results is both meaningful and valuable. Despite this trend, a comparative analysis of the effects of different exercise and diet combinations is lacking. This study uses network meta-analysis to evaluate the impact of various combined interventions on body composition and to compare their efficacy. Methods: We systematically reviewed literature from database inception through May 2024, searching PubMed, Web of Science, Embase, and the Cochrane Library. The study was registered in PROSPERO under the title: "Effects of Exercise Combined with Different Dietary Interventions on Body Composition: A Systematic Review and Network Meta-Analysis" (identifier: CRD42024542184). Studies were meticulously selected based on specific inclusion and exclusion criteria (The included studies must be randomized controlled trials involving healthy adults aged 18 to 65 years. Articles were rigorously screened according to the specified inclusion and exclusion criteria.), and their risk of bias was assessed using the Cochrane risk of bias tool. Data were aggregated and analyzed using network meta-analysis, with intervention efficacy ranked by Surface Under the Cumulative Ranking (SUCRA) curves. Results: The network meta-analysis included 78 randomized controlled trials with 5219 participants, comparing the effects of four combined interventions: exercise with calorie restriction (CR+EX), exercise with time-restricted eating (TRF+EX), exercise with 5/2 intermittent fasting (5/2F+EX), and exercise with a ketogenic diet (KD+EX) on body composition. Intervention efficacy ranking was as follows: (1) Weight Reduction: CR+EX > KD+EX > TRF+EX > 5/2F+EX (Relative to CR+EX, the effect sizes of 5/2F+EX, TRF+EX and KD+EX are 2.94 (−3.64, 9.52); 2.37 (−0.40, 5.15); 1.80 (−1.75, 5.34)). (2) BMI: CR+EX > KD+EX > 5/2F+EX > TRF+EX (Relative to CR+EX, the effect sizes of 5/2F+EX, TRF+EX and KD+EX are 1.95 (−0.49, 4.39); 2.20 (1.08, 3.32); 1.23 (−0.26, 2.71)). (3) Body Fat Percentage: CR+EX > 5/2F+EX > TRF+EX > KD+EX (Relative to CR+EX, the effect sizes of 5/2F+EX, TRF+EX and KD+EX are 2.66 (−1.56, 6.89); 2.84 (0.56, 5.13); 3.14 (0.52, 5.75).). (4) Lean Body Mass in Male: CR+EX > TRF+EX > KD+EX (Relative to CR+EX, the effect sizes of TRF+EX and KD+EX are −1.60 (−6.98, 3.78); −2.76 (−7.93, 2.40)). (5) Lean Body Mass in Female: TRF+EX > CR+EX > 5/2F+EX > KD+EX (Relative to TRF+EX, the effect sizes of CR+EX, 5/2F+EX and KD+EX are −0.52 (−2.58, 1.55); −1.83 (−4.71, 1.04); −2.46 (−5.69,0.76).). Conclusion: Calorie restriction combined with exercise emerged as the most effective strategy for reducing weight and fat percentage while maintaining lean body mass. For women, combining exercise with time-restricted eating proved optimal for preserving muscle mass. While combining exercise with a ketogenic diet effectively reduces weight, it is comparatively less effective at decreasing fat percentage and preserving lean body mass. Hence, the ketogenic diet combined with exercise is considered suboptimal. [ABSTRACT FROM AUTHOR]

Background: The benefits of exercise are well known; however, many of the underlying molecular mechanisms are not fully understood. Skeletal muscle secretes myokines, which mediate muscle–organ crosstalk. Myokines regulate satellite-cell proliferation and migration, inflammatory cascade, insulin secretion, angiogenesis, fatty oxidation, and cancer suppression. To date, the effects of different exercise modes (namely, aerobic and resistance exercise) on myokine response remain to be elucidated. This is crucial considering the clinical implementation of exercise to enhance general health and wellbeing and as a medical treatment. Methods: A systematic search was undertaken in PubMed, MEDLINE, CINAHL, Embase, SPORTDiscus, and Web of Science in April 2023. Eligible studies examining the effects of a single bout of exercise on interleukin15 (IL-15), irisin, secreted protein acidic and rich in cysteine (SPARC), oncostatin M (OSM), and decorin were included. A random-effects meta-analysis was also undertaken to quantify the magnitude of change. Results: Sixty-two studies were included (n = 1193). Overall, exercise appeared to induce small to large increases in myokine expression, with effects observed immediately after to 60 min post-exercise, although these were mostly not statistically significant. Both aerobic and resistance exercise resulted in changes in myokine levels, without any significant difference between training modes, and with the magnitude of change differing across myokines. Myokine levels returned to baseline levels within 180 min to 24 h post-exercise. However, owing to potential sources of heterogeneity, most changes were not statistically significant, indicating that precise conclusions cannot be drawn. Conclusion: Knowledge is limited but expanding with respect to the impact of overall and specific effects of exercise on myokine expression at different time points in the systemic circulation. Further research is required to investigate the effects of different exercise modes at multiple time points on myokine response.

Abstract We examined how resistance exercise (RE), cycling exercise and disuse atrophy affect myosin heavy chain (MyHC) protein fragmentation. The 1boutRE study involved younger men (n = 8; 5 ± 2 years of RE experience) performing a lower body RE bout with vastus lateralis (VL) biopsies being obtained prior to and acutely following exercise. With the 10weekRT study, VL biopsies were obtained in 36 younger adults before and 24 h after their first/naïve RE bout. Participants also engaged in 10 weeks of resistance training and donated VL biopsies before and 24 h after their last RE bout. VL biopsies were also examined in an acute cycling study (n = 7) and a study involving 2 weeks of leg immobilization (n = 20). In the 1boutRE study, fragmentation of all MyHC isoforms (MyHCTotal) increased 3 h post‐RE (∼200%, P = 0.018) and returned to pre‐exercise levels by 6 h post‐RE. Interestingly, a greater magnitude increase in MyHC type IIa versus I isoform fragmentation occurred 3 h post‐RE (8.6 ± 6.3‐fold vs. 2.1 ± 0.7‐fold, P = 0.018). In 10weekRT participants, the first/naïve and last RE bouts increased MyHCTotal fragmentation 24 h post‐RE (+65% and +36%, P

Abstract Dynamic resistance exercise (RE) produces sinusoidal fluctuations in blood pressure with simultaneous fluctuations in middle cerebral artery blood velocity (MCAv). Some evidence indicates that RE may alter cerebrovascular function. This study aimed to examine the effects of habitual RE training on the within‐RE cerebrovascular responses. RE‐trained (n = 15, Female = 4) and healthy untrained individuals (n = 15, Female = 12) completed four sets of 10 paced repetitions (15 repetitions per minute) of unilateral leg extension exercise at 60% of predicted 1 repetition maximum. Beat‐to‐beat blood pressure, MCAv and end‐tidal carbon dioxide were measured throughout. Zenith, nadir and zenith‐to‐nadir difference in mean arterial blood pressure (MAP) and mean MCAv (MCAvmean) for each repetition were averaged across each set. Two‐way ANOVA was used to analyse dependent variables (training × sets), Bonferroni corrected t‐tests were used for post hoc pairwise comparisons. Group age (26 ± 7 trained vs. 25 ± 6 years untrained, P = 0.683) and weight (78 ± 15 vs. 71 ± 15 kg, P = 0.683) were not different. During exercise average MAP was greater for the RE‐trained group in sets 2, 3 and 4 (e.g., set 4: 101 ± 11 vs. 92 ± 7 mmHg for RE trained and untrained, respectively, post hoc tests all P =

This study aimed to explore the effects of mental fatigue (MF) induced by an incongruent Stroop task (ST) and by using social media (SM) compared to watching a documentary (control) on dynamic resistance training. Twenty-one resistance-trained males attended three identical experimental sessions with the only difference of the randomized cognitive task (ST, SM, or control). Each session consisted of (a) baseline MF and motivation visual analogue scale responses, (b) cognitive task, (c) postvisual analogue scale responses, (d) warm-up, and (e) resistance training based on three sets of bench press at 65% of one-repetition maximum till concentric failure. Number of repetitions, ratings of perceived exertion, mean velocity of repetitions, and three repetitions in reserve estimated by subjects were recorded for each set. Both ST (p <.001) and SM (p =.010) effectively induced MF, but only ST impaired the number of repetitions performed in Set 2 (p =.036) and generated higher-than-normal levels of ratings of perceived exertion even reaching significant differences compared to SM in Set 1 (p =.005). However, SM also affected neuromuscular performance by impairing movement velocity in Set 1 (p =.003). The ability of estimating three repetitions in reserve or motivation was not affected by any condition (p range =.362–.979). MF induced by ST impaired the number of repetitions performed, what seems to be mediated by higher-than-normal levels of ratings of perceived exertion. Besides, SM also impaired the ability to apply force against 65% of one-repetition maximum measured by movement velocity. [ABSTRACT FROM AUTHOR]

This study compared the effects of an increasing-intensity (UP) and a decreasing-intensity (DOWN) resistance training protocol on affective responses across six training sessions. Novice participants (Mage 43.5 ± 13.7 years) were randomly assigned to UP (n = 18) or DOWN (n = 17) resistance training groups. Linear mixed-effects models showed that the evolution of affective valence within each training session was significantly moderated by the group (b = −0.45, p ≤.001), with participants in the UP group reporting a decline in pleasure during each session (b = −0.82) and the DOWN group reporting an improvement (b = 0.97; ps <.001). Remembered pleasure was significantly higher in the DOWN group compared to the UP group (b = 0.57, p =.004). These findings indicate that a pattern of decreasing intensity throughout a resistance exercise session can elicit more positive affective responses and retrospective affective evaluations of resistance training. [ABSTRACT FROM AUTHOR]

BACKGROUND: Sarcopenia refers to age-related progressive, systemic muscle mass reduction and/or muscle strength decline or muscle physiological function decline, which is related to the occurrence of a variety of adverse outcomes in older adults. Exercise is considered to be one of the main strategies for combating sarcopenia in older adults, but there is a lack of specific intervention methods of different exercise patterns to intervene in sarcopenia. OBJECTIVE: To elaborate the main influencing factors of sarcopenia and the research progress of different exercise methods to improve sarcopenia in older adults, providing reference and basis for combating sarcopenia in older adults. METHODS: Web of Science, PubMed, CNKI, VIP, WanFang databases were retrieved for relevant literature published from January 2000 to October 2023 using the keywords of “sarcopenia, sport, exercise intervention, resistant training, aerobic exercise, whole body vibration training, mixed training, physical performance, muscle strength, muscle mass” in Chinese and English, respectively. A total of 126 articles were included for review. RESULTS AND CONCLUSION: Resistance exercise is still the most effective way to prevent and treat senile sarcopenia, and the effect of high-intensity resistance exercise is more significant. However, in practical application, we should pay attention to the gradual increase of training load intensity. Aerobic exercise combined with resistance exercise is more effective to improve muscle mass and function in the elderly than a single exercise mode. It is suggested that older adults can carry out the transition of low-intensity aerobic exercise in the early stage and increase resistance exercise individually in the late stage. Whole body vibration training is a new treatment method for the prevention and treatment of senile sarcopenia, but particular attention should be paid to the effects of frequency, amplitude, and duration on patients during practical application. Multicomponent exercise combines different exercise modes, which can give full play to their respective advantages, so as to personalize exercise interventions. [ABSTRACT FROM AUTHOR]

Aims: In the present intervention study, low-velocity-loss (LVL) versus high-velocity-loss (HVL) thresholds in the squat and bench press were compared for changes in muscle strength, power, and hypertrophy. Methods: Strength-trained volunteers (7♀ and 9♂; age: 27.2 [3.4] y; height: 174.6 [8.0] cm; body mass: 75.3 [10.1] kg) were randomized into an LVL or HVL threshold group (LVL n = 3♀ + 5♂, and HVL n = 4♀ + 4♂). Training took place 3 times per week over 6 weeks (loads: ∼75%–90% of 1-repetition maximum [1RM]). The thresholds of LVLs and HVLs were set at 20% and 40% of maximal velocity, respectively, for the squat, and at 30% and 60%, respectively, for the bench press. Before and after the intervention, 1RM, leg press power, and squat jump were tested. The load (∼45% of 1RM) corresponding to 1-m/s velocity was assessed in all sessions for both exercises. In addition, the thickness of the vastus lateralis and triceps brachii and body composition (dual-energy X-ray absorptiometry [DEXA]) were measured. Results: Squat and bench-press 1RM increased similarly in both groups by 7% to 11% (SD: 4%–6%, P <.05). No group differences were observed for changes in jump height, leg press power, or DEXA lean mass. However, HVL showed a small increase in muscle thickness of the vastus lateralis compared with LVL (6 ± 6% [95% CI] group difference, P <.05). Conclusion: For strength-trained individuals, high-volume lower-velocity-loss thresholds were as effective as higher thresholds for improvements in 1RM strength; but local hypertrophy was seemingly elicited faster with higher velocity-loss thresholds. [ABSTRACT FROM AUTHOR]

Abstract Squatting, a traditional resistance exercise classified as strength training, relies on anaerobic pathways, but its aerobic aspects remain unclear. We examined heart rate and oxygen demand during squats, exploring variations across different strength statuses. It fills gaps in understanding the cardiorespiratory effects of squatting, especially during multiple sets. Twenty-two young healthy resistance trained men (age: 28 ± 4 years) participated. Maximal oxygen consumption (V̇O2max) and 1 repetition maximum (RM) of squat were measured. Participants performed 5 sets of squat exercises at 65% of 1RM for 10 repetitions with 3-min rest intervals. Heart rate and pulmonary gas exchange were measured during the squat exercise. Participants were divided into high strength (HS; upper 50%) and low strength (LS; lower 50%) groups based on a median split of their 1 RM squat values (normalized to their body weight). During 5 sets of squat exercise, oxygen consumption (V̇O2) increased up to 47.8 ± 8.9 ml/kg/min, corresponding to 100.6% of predetermined V̇O2max. The HS group achieved a greater highest point of V̇O2 in relation to V̇O2max than the LS group (108.0 vs. 93.7%). During the exercise intervals, V̇O2 exceeded V̇CO2, while during the rest intervals, V̇CO2 surpassed V̇O2. Our findings suggest that the oxygen demand during squatting is notably substantial, which may vary according to the training status.

Abstract Exercise‐induced muscle adaptations vary based on exercise modality and intensity. We constructed a signalling network model from 87 published studies of human or rodent skeletal muscle cell responses to endurance or resistance exercise in vivo or simulated exercise in vitro. The network comprises 259 signalling interactions between 120 nodes, representing eight membrane receptors and eight canonical signalling pathways regulating 14 transcriptional regulators, 28 target genes and 12 exercise‐induced phenotypes. Using this network, we formulated a logic‐based ordinary differential equation model predicting time‐dependent molecular and phenotypic alterations following acute endurance and resistance exercises. Compared with nine independent studies, the model accurately predicted 18/21 (85%) acute responses to resistance exercise and 12/16 (75%) acute responses to endurance exercise. Detailed sensitivity analysis of differential phenotypic responses to resistance and endurance training showed that, in the model, exercise regulates cell growth and protein synthesis primarily by signalling via mechanistic target of rapamycin, which is activated by Akt and inhibited in endurance exercise by AMP‐activated protein kinase. Endurance exercise preferentially activates inflammation via reactive oxygen species and nuclear factor κB signalling. Furthermore, the expected preferential activation of mitochondrial biogenesis by endurance exercise was counterbalanced in the model by protein kinase C in response to resistance training. This model provides a new tool for investigating cross‐talk between skeletal muscle signalling pathways activated by endurance and resistance exercise, and the mechanisms of interactions such as the interference effects of endurance training on resistance exercise outcomes.

Percussive therapy devices have been proven effective at reducing muscle inflammation, soreness, and tension and improving the range of motion before or after exercise. However, there is a notable lack of research on percussive therapy intra-exercise. Purpose: Examine the physiological responses (i.e., sets/reps) to percussive therapy during single-arm biceps curls (BCs) and single-leg quadriceps extensions (LEs). Methods: Participants [N = 26, 10 females] completed an initial 10-repetition maximum (10 RM) for BCs and LEs. Following that, participants completed two testing sessions in which BCs and LEs were completed at their 10 RM until functional failure (i.e., p = 0.002; Cohen’s d = 0.54] and reps [p = 0.005; Cohen’s d = 0.51] during the control condition relative to the percussive therapy condition. There were no differences between body parts (i.e., BC vs. LE) or interaction effects. Conclusion: This study provides evidence that low-frequency long-duration percussive therapy used intra-resistance exercise decreases performance parameters.

Objective To investigate the effect of resistance exercise on self-management ability, vascular diastolic function and atherosclerosis in patients with hypertension. Methods A total of 160 patients with hypertension treated in Sinopharm Dongfeng General Hospital from December 2019 to January 2022 were enrolled in this study. Patients were divided into study group (n=80) and traditional group (n=80) by random number table method. The traditional group was given routine aerobic exercise training based on drug therapy, and the research group was given resistance exercise training based on traditional therapy. Patients in both groups received intervention for 3 months, and the changes of vascular endothelial diastolic function and atherosclerosis were compared and analyzed before and after training. Results After training , the systolic blood pressure and diastolic blood pressure of the two groups decreased significantly compared with those before training (P＜0.05), and the study group was significantly lower than the traditional group (P＜0.05). The scores of self-management ability (45.28±3.17, 40.10±2.22) in the study group and traditional group were significantly higher than those before training (31.48±3.18, 31.54±2.58); The score of self-management ability in study group was significantly lower than that in traditional group (t=141.972, P＜0.05). The serum levels of lipoprotein-associated phospholipase 2 (Lp-PLA2) and homocysteine (Hcy) in two groups decreased significantly compared with those before training (P＜0.05)，and the levels of serum Lp-PLA2 and Hcy in the study group were significantly higher than those in the traditional group (P＜0.05). The change rate of artery diameter and the change rate of artery diameter of endothelium-dependent vasodilation function in the two groups were significantly higher than those before training, and the study group was significantly higher than the traditional group (P＜0.05). There was no significant difference in carotid intima-media thickness between the two groups after training and before training, and there was no significant difference between the study group and the traditional group (P＞0.05). Conclusion Resistance exercise can improve vascular endothelial relaxation function and atherosclerosis status, inhibit the expression of Lp-PLA2 and Hcy, reduce blood pressure continuously, and improve the self-management ability of patients with hypertension.

The article analyzes the effect of different physiotherapy programs on trunk stability and functional movements in middle-distance runners. Significant changes of trunk stability, functional movement stereotype, endurance of trunk muscles, dynamic stability are shown in the charts.

Abstract Background Proliferating cancer cells shift their metabolism towards glycolysis, even in the presence of oxygen, to especially generate glycolytic intermediates as substrates for anabolic reactions. We hypothesize that a similar metabolic remodelling occurs during skeletal muscle hypertrophy. Methods We used mass spectrometry in hypertrophying C2C12 myotubes in vitro and plantaris mouse muscle in vivo and assessed metabolomic changes and the incorporation of the [U‐13C6]glucose tracer. We performed enzyme inhibition of the key serine synthesis pathway enzyme phosphoglycerate dehydrogenase (Phgdh) for further mechanistic analysis and conducted a systematic review to align any changes in metabolomics during muscle growth with published findings. Finally, the UK Biobank was used to link the findings to population level. Results The metabolomics analysis in myotubes revealed insulin‐like growth factor‐1 (IGF‐1)‐induced altered metabolite concentrations in anabolic pathways such as pentose phosphate (ribose‐5‐phosphate/ribulose‐5‐phosphate: +40%; P = 0.01) and serine synthesis pathway (serine: −36.8%; P = 0.009). Like the hypertrophy stimulation with IGF‐1 in myotubes in vitro, the concentration of the dipeptide l‐carnosine was decreased by 26.6% (P = 0.001) during skeletal muscle growth in vivo. However, phosphorylated sugar (glucose‐6‐phosphate, fructose‐6‐phosphate or glucose‐1‐phosphate) decreased by 32.2% (P = 0.004) in the overloaded muscle in vivo while increasing in the IGF‐1‐stimulated myotubes in vitro. The systematic review revealed that 10 metabolites linked to muscle hypertrophy were directly associated with glycolysis and its interconnected anabolic pathways. We demonstrated that labelled carbon from [U‐13C6]glucose is increasingly incorporated by ~13% (P = 0.001) into the non‐essential amino acids in hypertrophying myotubes, which is accompanied by an increased depletion of media serine (P = 0.006). The inhibition of Phgdh suppressed muscle protein synthesis in growing myotubes by 58.1% (P

Background: To minimize fracture risk, multimodal training regimens are recommended. However, their effectiveness in community settings remains uncertain. This study evaluated the feasibility of 19-weeks of multimodal training in a local community center with emphasis on musculoskeletal health in postmenopausal women. Methods: In a controlled trial, 28 postmenopausal women (53-68-years-old) were assigned to a multimodal training group (MMT, n=15) or a control group (CON, n=13). The training consisted of high- and odd-impact, resistance and balance-coordination training 1-2 hours weekly. The outcomes were attendance rate, regional and total bone mineral density (BMD), bone mineral content (BMC), bone turnover markers (BTM), body composition, functional muscle strength and power, and dynamic balance. All were determined at baseline and after 19 weeks of training. BTM was assessed after three weeks. Results: Overall, 22(79%) participants (MMT, n=9; CON, n=13) completed the study, and the mean attendance rate for MMT was 65.5% of the maximum sessions (2) offered. Only right trochanter BMD increased (p Conclusions: Nineteen weeks of multimodal training 1-2 hours per week in a local community had a health-enhancing effect on %BF, FM, and VAT, whereas the musculoskeletal health impact was modest. We hypothesize that the reason might be too low training volume and frequency and supposedly too low musculoskeletal training intensity for some participants. Registration: ClinicalTrials.gov NCT05164679 (21/12/2021).

Females historically experience sleep disturbances and overall poor sleep compared to males. Creatine has been proposed to impact sleep; however, the effects are not well known. The purpose of this study was to examine the effects of creatine supplementation on sleep among naturally menstruating females. Twenty-one participants completed a double-blind, randomized controlled trial in which they consumed 5 g creatine + 5 g maltodextrin or placebo, 10 g maltodextrin, daily for 6 weeks. Participants completed resistance training 2x/week using the TONAL® (Tonal Systems Inc., San Francisco, CA, USA) at-home gym. Pre- and post-testing assessed body composition, Pittsburgh Sleep Quality Index (PSQI), dietary intake, and muscular strength. Sleep was assessed nightly using an ŌURA® (Oulu, Finland) ring. Compared to the placebo group, those consuming creatine experienced significant increases in total sleep on training days (p = 0.013). No significant changes in chronic sleep and PSQI (pre–post) were observed. There was a significant increase in TONAL® strength score over time (p < 0.001), with no between-group differences. Participants reduced their total calorie (kcal) (p = 0.039), protein (g/kg) (p = 0.009), carbohydrate (g/kg) (p = 0.023), and fat (g) (p = 0.036) intake over time. Creatine supplementation increases sleep duration on resistance training days in naturally menstruating females. [ABSTRACT FROM AUTHOR]

Introduction The convergence of sports and health is a developing area, focusing on the therapeutic potential of physical activities in numerous chronic disease management strategies as a necessary part of a holistic strategy. Acknowledging sports as a therapeutic tool emphasizes the necessity for a comprehensive understanding of how sports engagement contributes to innovative healthcare interventions. Purpose This research aims to investigate the therapeutic potential of prescribing sports and physical exercise in treating primary chronic diseases, exploring its integration into health care practices with a focus on efficacy and implications for disease management. State of Knowledge Physical activity is recommended for treating diabetes, chronic obstructive pulmonary disease, asthma, and rheumatoid arthritis. It reduces the risk of cardiovascular disease and death, lowers blood pressure, ads prevents and manages atherosclerosis and osteoporosis. Non-physical sports like chess and board games also promise protection against dementia, depression, and Alzheimer's. Conclusions Incorporating sports into healthcare policies and prescribing personalized exercise are essential components of holistic chronic disease management and show widespread benefits. Professional guidance and clear recommendations, aligned with disease-specific guidelines, play a crucial role in ensuring safe and effective physical activity for patients. Potential risks in specific populations, particularly injury risks, can be minimized through proper preventive measures, adjusting the character of exercises, and heightened patient awareness. To ensure good compliance, exercise prescriptions should offer clear and precise guidelines. [ABSTRACT FROM AUTHOR]

Purpose: A combined body weight loss and upper body/arm exercise programme is a potential strategy for managing Breast cancer related lymphoedema (BCRL), but there is limited data on the best method for delivery or its potential efficacy. Methods: Fifty-seven women with overweight/obesity and BCRL were randomised to a 12 week supervised (n = 12) or home-based combined weight loss and upper body/arm exercise programme (n = 16), a home-based upper-body arm exercise only programme (n = 17) or standard care (n = 12). Primary outcomes were uptake, retention and changes in weight and change in Relative Arm Volume Increase (RAVI) using analysis of covariance (ANCOVA). Results: Sixteen percent of women invited joined the study and 49 completed the trial (85% retention). Reductions in weight occurred in the supervised and home-based weight control and exercise programmes; Mean (95% CI) change compared to standard care − 1.68 (− 4.36 to − 1.00), − 2.47(− 4.99 to − 0.04) Kg. Reductions in perometer assessed RAVI were seen in the supervised and home-based combined weight control and arm exercise groups and the weight stable home-based arm exercise only group: mean (95% CI) change compared to standard care − 2.4 (− 5.0 to + 0.4),− 1.8 (− 4.3 to + 0.7), − 2.5(− 4.9 to − 0.05)%. Conclusion: Women with BCRL and overweight and obesity engaged in diet and exercise weight loss programmes. Both weight loss/arm exercise programmes led to modest changes in weight and BCRL. Comparable reductions in BCRL were reported in the weight stable group undertaking arm exercise only. The independent and combined effects of weight loss and exercise on BCRL need further study. Trial registration: ISRCTN86789850 https://doi.org/10.1186/ISRCTN86789850, registered 2011. [ABSTRACT FROM AUTHOR]

Squatting, a traditional resistance exercise classified as strength training, relies on anaerobic pathways, but its aerobic aspects remain unclear. We examined heart rate and oxygen demand during squats, exploring variations across different strength statuses. It fills gaps in understanding the cardiorespiratory effects of squatting, especially during multiple sets. Twenty-two young healthy resistance trained men (age: 28 ± 4 years) participated. Maximal oxygen consumption (V̇O2max) and 1 repetition maximum (RM) of squat were measured. Participants performed 5 sets of squat exercises at 65% of 1RM for 10 repetitions with 3-min rest intervals. Heart rate and pulmonary gas exchange were measured during the squat exercise. Participants were divided into high strength (HS; upper 50%) and low strength (LS; lower 50%) groups based on a median split of their 1 RM squat values (normalized to their body weight). During 5 sets of squat exercise, oxygen consumption (V̇O2) increased up to 47.8 ± 8.9 ml/kg/min, corresponding to 100.6% of predetermined V̇O2max. The HS group achieved a greater highest point of V̇O2 in relation to V̇O2max than the LS group (108.0 vs. 93.7%). During the exercise intervals, V̇O2 exceeded V̇CO2, while during the rest intervals, V̇CO2 surpassed V̇O2. Our findings suggest that the oxygen demand during squatting is notably substantial, which may vary according to the training status. [ABSTRACT FROM AUTHOR]

Although literature suggests that exercise can improve symptoms in Parkinson’s Disease (PD) patients, research on the effects of aerobic exercise and resistance training (AE&RT) in early-stage PD remains limited. Understanding the synergistic effects of these exercise modalities can provide valuable insights for optimizing exercise interventions for PD patients, particularly in the early stages of the disease, where interventions may have the greatest impact on long-term functional outcomes. This study aimed to investigate the effects of a combined AE&RT program on motor function, postural stability, and cognitive processing speed in early stage PD patients. A total of 236 participants with early-stage PD were assigned to either the Aerobic Exercise Group (AE group) (n= 112) or the AE&RT Group (n= 124) inthis controlled randomized trial. The study employed a one-year supervised exercise program, with the AE Group participating in aerobic activities and the AE&RT Group engaging in combined AE&RT. Outcome measures included symptom improvement, motor function, postural stability, cognitive processing speed, peak oxygen consumption, quality of life evaluation, and the incidence of adverse events. The AE&RT Group demonstrated greater improvements in tremor, muscle rigidity, gait instability, sleep problems, and hyposmia compared to the AE Group. Additionally, the combined exercise group exhibited better cognitive processing speed, as well as enhanced motor function and postural stability. Peak oxygen consumption was significantly higher in the AE&RT Group. However, the quality of life evaluation indicated a statistically higher quality of life in the AE Group. There was no significant difference in the incidence of adverse events between the two groups. The findings suggest that the integration of AE&RT in early-stage PD patients leads to more comprehensive improvements in motor symptoms, cognitive function, postural stability, and cardiovascular fitness compared to aerobic exercise alone. These results have important implications for developing tailored exercise interventions to enhance the physical and cognitive well-being of individuals with early-stage PD. [ABSTRACT FROM AUTHOR]

The objectives of our study were 1) to examine whether the force-velocity-power (FvP) outcomes in the concentric and eccentric phases of flywheel (FW) squats differ among sports disciplines and 2) to investigate the association between FvP outcome variables and two key sport-performance indicators: countermovement jump height (CMJ) and change of direction (CoD) time involving 90° or 180° turns. Tests were performed by 469 athletes from five different sport disciplines and physical education students. Our results showed that FvP outcomes, when measured during the eccentric phase of the FW squat, effectively differed between athletes from different sports. However, during the concentric phase of the squat, only for the slope variable differences between sports were found. Contrary to our hypothesis, there were no statistically significant correlations between FW squat FvP outcomes and CMJ or CoD test results. These results suggest that FvP outcomes derived from FW squats may lack external validity and cannot be reliably used as a predictor of athletes' jumping and agility performance. The paper discusses possible reasons for the larger differences between sports in eccentric FvP outcomes, as well as the absence of correlations between FvP outcomes and functional tests. [ABSTRACT FROM AUTHOR]