1. Estimating the association between being seropositive for cysticercosis and the prevalence of epilepsy and severe chronic headaches in 60 villages of rural Burkina Faso
- Author
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Ida Sahlu, Cici Bauer, Pierre Dorny, Zekiba Tarnagda, Rasmané Ganaba, Athanase Millogo, Assana Cissé, Veronique Dermauw, Sarah Gabriël, Pierre-Marie Preux, Hélène Carabin, Department of Epidemiology [Brown University School of Public Health], Brown University School of Public Health -Brown University, Department of Biostastistics and Epidemiology [University of Oklahoma Health Sciences Center], University of Oklahoma (OU)-University of Oklahoma Health Sciences Center (OUHSC), Agence de Formation de Recherche et d'expertise en Santé pour l'Afrique (AFRICSanté), Neuroépidémiologie Tropicale (NET), CHU Limoges-Institut d'Epidémiologie Neurologique et de Neurologie Tropicale-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut Génomique, Environnement, Immunité, Santé, Thérapeutique (GEIST), Université de Limoges (UNILIM)-Université de Limoges (UNILIM), Service de l'Information Médicale et de l'Évaluation [CHU Limoges] (SIME), CHU Limoges, Laboratoire de Biostatistique et d'Informatique Médicale, Université de Limoges (UNILIM), Institut de Recherche en Sciences de la Santé Bobo Dioulasso (INSSA), Université Polytechnique Nazi Boni Bobo-Dioulasso (UNB), Research Group Veterinary Public Health and Zoonoses, Department of Veterinary Public Health and Food Safety, Laboratorium of Chemical Analysis, Universiteit Gent = Ghent University [Belgium] (UGENT), Department of Biomedical Sciences [Antwerp], Institute of Tropical Medicine [Antwerp] (ITM), Department of Biostatistics [Houston], MD Anderson Cancer Center [Houston], The University of Texas Health Science Center at Houston (UTHealth)- The University of Texas Health Science Center at Houston (UTHealth), Centre Hospitalier Universitaire Souro Sanou [Bobo-Dioulasso] (CHUSS), Grelier, Elisabeth, Brown University-Brown University School of Public Health, and Universiteit Gent = Ghent University (UGENT)
- Subjects
Male ,Rural Population ,Swine ,Cross-sectional study ,Health Care Providers ,RC955-962 ,Social Sciences ,Pathology and Laboratory Medicine ,MESH: Neurocysticercosis ,0302 clinical medicine ,Sociology ,MESH: Rural Population ,Surveys and Questionnaires ,MESH: Child ,Arctic medicine. Tropical medicine ,MESH: Animals ,Child ,Mammals ,Aged, 80 and over ,Schools ,MESH: Middle Aged ,Eukaryota ,3. Good health ,medicine.drug_formulation_ingredient ,Neurology ,MESH: Young Adult ,MESH: Epilepsy ,Public aspects of medicine ,BURDEN ,medicine.medical_specialty ,Headache Disorders ,DIAGNOSIS ,Education ,03 medical and health sciences ,Signs and Symptoms ,MESH: Cross-Sectional Studies ,Physicians ,Taenia solium ,Humans ,Migraine ,MESH: Prevalence ,Aged ,MESH: Adolescent ,MESH: Taenia solium ,Epilepsy ,MESH: Humans ,ILAE ,Organisms ,Public Health, Environmental and Occupational Health ,Biology and Life Sciences ,MESH: Adult ,Odds ratio ,Tropical Diseases ,medicine.disease ,Health Care ,Cross-Sectional Studies ,MESH: Randomized Controlled Trials as Topic ,030104 developmental biology ,Food ,Antigens, Helminth ,Population Groupings ,MESH: Female ,0301 basic medicine ,Pediatrics ,Medical Doctors ,Neurocysticercosis ,NEUROCYSTICERCOSIS ,MESH: Aged, 80 and over ,Animal Products ,Epidemiology ,Prevalence ,Medicine and Health Sciences ,EPIDEMIOLOGY ,Pork ,Medical Personnel ,Randomized Controlled Trials as Topic ,MESH: Aged ,Headaches ,Agriculture ,Cysticercosis ,Middle Aged ,COMMUNITY ,Professions ,Infectious Diseases ,MIGRAINE ,Helminth Infections ,Vertebrates ,Female ,medicine.symptom ,RA1-1270 ,Research Article ,Neglected Tropical Diseases ,Adult ,Meat ,Adolescent ,030231 tropical medicine ,MESH: Antigens, Helminth ,Young Adult ,Diagnostic Medicine ,Burkina Faso ,parasitic diseases ,Parasitic Diseases ,medicine ,Animals ,MESH: Burkina Faso ,MESH: Surveys and Questionnaires ,Nutrition ,business.industry ,MESH: Male ,Diet ,[SDV.SPEE] Life Sciences [q-bio]/Santé publique et épidémiologie ,People and Places ,Amniotes ,MESH: Headache Disorders ,[SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie ,business - Abstract
Background Individuals diagnosed with neurocysticercosis often present with epilepsy and sometimes with progressively worsening severe chronic headaches (WSCH). While cross-sectional associations between seropositivity to cysticercal antigens and epilepsy have been reported, few large scale studies have been conducted in West Africa and none have measured the association between seropositivity to cysticercal antigens and headaches. This study aimed at filling these knowledge gaps by estimating the strength of the cross-sectional association between seropositivity to cysticercal antigens and the prevalence of epilepsy and WSCH in 60 villages of Burkina Faso, West Africa. Methodology/Principal findings Baseline data from a cluster randomized controlled trial collected from January 2011 to February 2012 in 60 villages across three provinces in Burkina Faso were used. Between 78 and 80 individuals were screened for epilepsy and WSCH in each village, and those screened positive were confirmed by a physician. Seventy-five percent of all participants were asked to provide a blood sample to test for Taenia solium cysticercus circulating antigens. Hierarchical multivariable logistic models were used to measure the association between seropositivity to cysticercal antigens and epilepsy (lifetime and active) as well as WSCH. Among 3696 individuals who provided a blood sample, 145 were found to have epilepsy only, 140 WSCH only and 19 both. There were positive associations between seropositivity to cysticercal antigens and active epilepsy (prevalence odds ratio (POR): 2.40 (95%CI: 1.15–5.00)) and WSCH (POR: 2.59 (1.34–4.99)). Conclusions/Significance Our study is the first to demonstrate a cross-sectional association between seropositivity to cysticercal antigens and WSCH in a large community-based study conducted in West Africa. The measured cross-sectional association had a strength similar to the ones previously observed between seropositivity to cysticercal antigens and lifetime or active epilepsy. As a result, preventing new cysticercosis cases in communities may reduce the prevalence of these two important neurological disorders., Author summary Taenia solium is a parasite that can be transmitted between humans and pigs in areas with poor sanitation and pig management practices. When this parasite infects the human brain, it can cause epilepsy or severe headaches. Our study aimed to measure the association between being seropositive to cysticercal antigens and having epilepsy (lifetime and active) or severe headaches in 60 villages of Burkina Faso. We found that active epilepsy and severe headaches were associated with seropositivity to cysticercal antigens. These results confirm prior studies which suggested an association between being seropositive for cysticercal antigens and these two neurological symptoms. Preventing cysticercosis could reduce new cases of these two neurological symptoms from occurring.
- Published
- 2019