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28 results on '"Resa, Sandra"'

7. Chimeric Drug Design with a Noncharged Carrier for Mitochondrial Delivery

Author

Ripoll, Consuelo, primary, Herrero-Foncubierta, Pilar, additional, Puente-Muñoz, Virginia, additional, Gonzalez-Garcia, M. Carmen, additional, Miguel, Delia, additional, Resa, Sandra, additional, Paredes, Jose M., additional, Ruedas-Rama, Maria J., additional, Garcia-Fernandez, Emilio, additional, Roldan, Mar, additional, Rocha, Susana, additional, De Keersmaecker, Herlinde, additional, Hofkens, Johan, additional, Martin, Miguel, additional, Cuerva, Juan M., additional, and Orte, Angel, additional

Published
2021
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8. Extended enantiopure ortho-phenylene ethylene (o-OPE)-based helical systems as scaffolds for supramolecular architectures: a study of chiroptical response and its connection to the CISS effect

Author

Ortuño, Ana M., primary, Reiné, Pablo, additional, Resa, Sandra, additional, Álvarez de Cienfuegos, Luis, additional, Blanco, Victor, additional, Paredes, José Manuel, additional, Mota, Antonio J., additional, Mazzeo, Giuseppe, additional, Abbate, Sergio, additional, Ugalde, Jesus M., additional, Mujica, Vladimiro, additional, Longhi, Giovanna, additional, Miguel, Delia, additional, and Cuerva, Juan Manuel, additional

Published
2021
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9. Chimeric Drug Design with a Noncharged Carrier for Mitochondrial Delivery

Author

Ripoll, Consuelo, primary, Herrero-Foncubierta, Pilar, additional, Puente-Muñoz, Virginia, additional, Gonzalez-Garcia, M. Carmen, additional, Miguel, Delia, additional, Resa, Sandra, additional, Paredes, Jose M., additional, Ruedas-Rama, Maria J., additional, Garcia-Fernandez, Emilio, additional, Martin, Miguel, additional, Roldan, Mar, additional, Rocha, Susana, additional, De Keersmaecker, Herlinde, additional, Hofkens, Johan, additional, Cuerva, Juan M., additional, and Orte, Angel, additional

Published
2020
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10. Enantiopure Double ortho‐Oligophenylethynylene‐Based Helical Structures with Circularly Polarized Luminescence Activity.

Author

Reiné, Pablo, Ortuño, Ana M., Resa, Sandra, Álvarez de Cienfuegos, Luis, Ribagorda, María, Mota, Antonio J., Abbate, Sergio, Longhi, Giovanna, Miguel, Delia, and Cuerva, Juan M.

Subjects
HELICAL structure, LUMINESCENCE, CIRCULAR dichroism, ZINC catalysts, COORDINATION polymers, OPTICAL properties, ISOMERS
Abstract

In this paper, we describe the optical and chiroptical properties of an enantiopure multipodal ortho‐oligophenylethynylene (S,S,S,S)‐1 presenting four chiral sulfoxide groups at the extremes. The presence of these groups together with alkynes allows the coordination with carbophilic Ag(I), and/or oxophilic Zn(II) cations, yielding double helical structures in an enantiopure way. In this sense, different behaviors in absorption, fluorescence, ECD and CPL spectra have been found depending on the stoichiometry and nature of the metal. We have observed that Zn(II) coordination favors an intensity increase of the electronic circular dichroism (ECD) spectra of compound (S,S,S,S)‐1 yielding an M‐helicity in the ortho‐oligophenylene ethynylene (o‐OPE) backbone. On the other hand, ECD spectra of final Ag(I) complex shows two different bands with an opposite sign to the free ligand, thus giving the P‐helical isomer. In addition, circularly polarized luminescence (CPL) exhibit an enhanced intensity and negative sign in both complexes. Computational studies were also carried out, supporting the experimental results. [ABSTRACT FROM AUTHOR]

Published
2022
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11. O-H and (CO)N-H bond weakening by coordination to Fe(ii)

Author

Ministerio de Economía y Competitividad (España), Junta de Andalucía, European Commission, Consejo Superior de Investigaciones Científicas (España), Resa, Sandra, Millán, Alba, Fuentes, Noelia, Crovetto, Luis, Marcos, María-Luisa, Lezama, Luis, Choquesillo-Lazarte, Duane, Blanco, Víctor, Campaña, Araceli G., Cárdenas, D. J., Cuerva, Juan M., Ministerio de Economía y Competitividad (España), Junta de Andalucía, European Commission, Consejo Superior de Investigaciones Científicas (España), Resa, Sandra, Millán, Alba, Fuentes, Noelia, Crovetto, Luis, Marcos, María-Luisa, Lezama, Luis, Choquesillo-Lazarte, Duane, Blanco, Víctor, Campaña, Araceli G., Cárdenas, D. J., and Cuerva, Juan M.

Abstract

New N,N′-dimethyl-N,N′-bis(2-pyridylmethyl)-ethane-1,2-diamine derivatives bearing covalently linked OH and (CO)NH groups have been synthesized. The coordination of those pendant hydroxyl/amide groups to a Fe(ii) metal center is demonstrated both in solution, even in the presence of chloride as the counterion, and in solid state, by means of X-ray diffraction crystal structures. As a result of this coordination, the experimental bond dissociation free energies (BDFE) of O-H and (CO)N-H bonds are remarkably diminished down to 76.0 and 80.5 kcal mol respectively, which is also in agreement with DFT-based theoretical calculations. These BDFE values are in the range of commonly used hydrogen-atom donor reagents. The strategy presented here allows an unequivocal evaluation of the influence of metal coordination in X-H bond weakening in organic solvents which could be easily extended to other metal centers.

Published
2019

12. Sulfoxide-Induced Homochiral Folding of o-OPEs by AgI Templating: Structure and Chiroptical Properties

Author

Resa, Sandra, Miguel Álvarez, Delia, Guisán-Ceinos, Santiago, Mazzeo, Giuseppe, Choquesillo Lazarte, Duane, Abbate, Sergio, Crovetto González, Luis, Cárdenas, Diego J., Carreño, M. Carmen, Ribagorda, María, Longhi, Giovanna, Mota Ávila, Antonio José, Álvarez Cienfuegos Rodríguez, Luis, and Cuerva Carvajal, Juan Manuel

Subjects
Chiroptical properties, Host-guest systems, Supramolecular Chemistry, Helical structures, Nanostructures
Abstract

"This is the peer reviewed version of the following article: Resa, S.; et al. Sulfoxide-Induced Homochiral Folding of o-OPEs by AgI Templating: Structure and Chiroptical Properties. Chemistry a European Journal, 2018, which has been published in final form at http://dx.doi.org/10.1002/chem.201704897 . This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving.", A new family of homochiral silver complexes based on carbophilic interactions with ortho-phenyleneethynylene (o-OPE) scaffolds containing up to two silver atoms is described. These compounds represent a unique class of complexes with chirality at the metal. Chiral induction is based on the inclusion of chiral sulfoxides which allow an efficient transfer of chirality to the helically folded o-OPE, leading to CPL and VCD active compounds. In the presence of AgI cation carbophilic interactions dominate, promoting helical structures with a defined helicity. This is one of the very scarce examples of the use of such interactions in the attractive field of abiotic foldamers. The switching event has been extensively studied using different chiroptical techniques including CD, CPL and VCD, also representing one of the few CPL switches described in literature., We thank MINECO (FEDER funded grant CTQ2014-53598-R). Computing Center CINECA, Bologna, Italy, Regione Lombardia for the LISA Grant No. “ChiPhyto: HPL13POZE1” and the “Centro de Supercomputación de la UGR” (UGRGRID) are acknowledged for access to computational facilities. Sandra Resa thanks the MECD for a FPU fellowship.

Published
2018
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14. O–H and (CO)N–H bond weakening by coordination to Fe(ii)

Author

Resa, Sandra, primary, Millán, Alba, additional, Fuentes, Noelia, additional, Crovetto, Luis, additional, Luisa Marcos, M., additional, Lezama, Luis, additional, Choquesillo-Lazarte, Duane, additional, Blanco, Victor, additional, Campaña, Araceli G., additional, Cárdenas, Diego J., additional, and Cuerva, Juan M., additional

Published
2019
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16. Sulfoxide-Induced Homochiral Folding of ortho-Phenylene Ethynylenes (o-OPEs) by Silver(I) Templating: Structure and Chiroptical Properties

Author

Ministerio de Economía y Competitividad (España), Ministerio de Educación, Cultura y Deporte (España), Resa, Sandra, Miguel, Delia, Guisán-Ceinos, Santiago, Mazzeo, Giuseppe, Choquesillo-Lazarte, Duane, Abbate, Sergio, Crovetto, Luis, Cárdenas, D. J., Carreño, M. C., Ribagorda, María, Longhi, Giovanna, Mota, Antonio J., Cienfuegos, Luis Álvarez de, Cuerva, Juan M., Ministerio de Economía y Competitividad (España), Ministerio de Educación, Cultura y Deporte (España), Resa, Sandra, Miguel, Delia, Guisán-Ceinos, Santiago, Mazzeo, Giuseppe, Choquesillo-Lazarte, Duane, Abbate, Sergio, Crovetto, Luis, Cárdenas, D. J., Carreño, M. C., Ribagorda, María, Longhi, Giovanna, Mota, Antonio J., Cienfuegos, Luis Álvarez de, and Cuerva, Juan M.

Abstract

A new family of homochiral silver complexes based on carbophilic interactions with ortho-phenylene ethynylene (o-OPE) scaffolds containing up to two silver atoms are described. These compounds represent a unique class of complexes with chirality at the metal. Chiral induction is based on the inclusion of chiral sulfoxides, which allow efficient transfer of chirality to the helically folded o-OPE, leading to circularly polarized luminescence (CPL)- and vibrational circular dichroism (VCD)-active compounds. In the presence of silver(I) cations, carbophilic interactions dominate, which promote helical structures with a defined helicity. This is one of the very scarce examples of the use of such interactions in the attractive field of abiotic foldamers. The switching event has been extensively studied by using different chiroptical techniques, including circular dichroism, CPL, and VCD, and represents one of the few CPL switches described in the literature.

Published
2018

18. Sulfoxide-Induced Homochiral Folding of ortho -Phenylene Ethynylenes (o -OPEs) by Silver(I) Templating: Structure and Chiroptical Properties

Author

Resa, Sandra, primary, Miguel, Delia, additional, Guisán-Ceinos, Santiago, additional, Mazzeo, Giuseppe, additional, Choquesillo-Lazarte, Duane, additional, Abbate, Sergio, additional, Crovetto, Luis, additional, Cárdenas, Diego J., additional, Carreño, M. Carmen, additional, Ribagorda, María, additional, Longhi, Giovanna, additional, Mota, Antonio J., additional, Álvarez de Cienfuegos, Luis, additional, and Cuerva, Juan M., additional

Published
2018
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19. OFF/ON switching of circularly polarized luminescence by oxophilic interaction of homochiral sulfoxide-containing o-OPEs with metal cations

Author

Reiné, Pablo, primary, Ortuño, Ana M., additional, Resa, Sandra, additional, Álvarez de Cienfuegos, Luis, additional, Blanco, Victor, additional, Ruedas-Rama, M. José, additional, Mazzeo, Giuseppe, additional, Abbate, Sergio, additional, Lucotti, Andrea, additional, Tommasini, Matteo, additional, Guisán-Ceinos, Santiago, additional, Ribagorda, Maria, additional, Campaña, Araceli G., additional, Mota, Antonio, additional, Longhi, Giovanna, additional, Miguel, Delia, additional, and Cuerva, Juan M., additional

Published
2018
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20. Sulfoxide‐Induced Homochiral Folding of <italic>ortho</italic>‐Phenylene Ethynylenes (<italic>o</italic>‐OPEs) by Silver(I) Templating: Structure and Chiroptical Properties.

Author

Resa, Sandra, Miguel, Delia, Guisán‐Ceinos, Santiago, Mazzeo, Giuseppe, Choquesillo‐Lazarte, Duane, Abbate, Sergio, Crovetto, Luis, Cárdenas, Diego J., Carreño, M. Carmen, Ribagorda, María, Longhi, Giovanna, Mota, Antonio J., Álvarez de Cienfuegos, Luis, and Cuerva, Juan M.

Subjects
SULFOXIDES, PHENYLENE compounds, SILVER compounds, VIBRATIONAL circular dichroism, CHIRALITY
Abstract

Abstract: A new family of homochiral silver complexes based on carbophilic interactions with ortho‐phenylene ethynylene (o‐OPE) scaffolds containing up to two silver atoms are described. These compounds represent a unique class of complexes with chirality at the metal. Chiral induction is based on the inclusion of chiral sulfoxides, which allow efficient transfer of chirality to the helically folded o‐OPE, leading to circularly polarized luminescence (CPL)‐ and vibrational circular dichroism (VCD)‐active compounds. In the presence of silver(I) cations, carbophilic interactions dominate, which promote helical structures with a defined helicity. This is one of the very scarce examples of the use of such interactions in the attractive field of abiotic foldamers. The switching event has been extensively studied by using different chiroptical techniques, including circular dichroism, CPL, and VCD, and represents one of the few CPL switches described in the literature. [ABSTRACT FROM AUTHOR]

Published
2018
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24. ChemInform Abstract: Ti(III)-Catalyzed Cyclizations of Ketoepoxypolyprenes: Control over the Number of Rings and Unexpected Stereoselectivities.

Author

Morcillo, Sara P., primary, Miguel, Delia, additional, Resa, Sandra, additional, Martin-Lasanta, Ana, additional, Millan, Alba, additional, Choquesillo-Lazarte, Duane, additional, Garcia-Ruiz, Juan M., additional, Mota, Antonio J., additional, Justicia, Jose, additional, and Cuerva, Juan M., additional

Published
2014
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28. New Dual Fluorescent Probe for Simultaneous Biothiol and Phosphate Bioimaging.

Author

Resa S, Orte A, Miguel D, Paredes JM, Puente-Muñoz V, Salto R, Giron MD, Ruedas-Rama MJ, Cuerva JM, Alvarez-Pez JM, and Crovetto L

Subjects
Female, Fluorescence, HeLa Cells, Humans, Hydrogen-Ion Concentration, Microscopy, Fluorescence, Molecular Structure, Phosphates analysis, Sulfhydryl Compounds analysis, Fluorescent Dyes chemistry, Nitro Compounds chemistry, Phosphates chemistry, Sulfhydryl Compounds chemistry, Sulfonium Compounds chemistry, Uterine Cervical Neoplasms chemistry, Xanthenes chemistry, Xanthines chemistry
Abstract

The simultaneous detection of relevant metabolites in living organisms by using one molecule introduces an approach to understanding the relationships between these metabolites in healthy and deregulated cells. Fluorescent probes of low toxicity are remarkable tools for this type of analysis of biological systems in vivo. As a proof of concept, different naturally occurring compounds, such as biothiols and phosphate anions, were the focus for this work. The 2,4-dinitrobenzenesulfinate (DNBS) derivative of 9-[1-(4-tert-butyl-2-methoxyphenyl)]-6-hydroxy-3H-xanthen-3-one (Granada Green; GG) were designed and synthesized. This new sulfinyl xanthene derivative can act as a dual sensor for the aforementioned analytes simultaneously. The mechanism of action of this derivative implies thiolysis of the sulfinyl group of the weakly fluorescent DNBS-GG by biological thiols at near-neutral pH values, thus releasing the fluorescent GG moiety, which simultaneously responds to phosphate anions through its fluorescence-decay time. The new dual probe was tested in solution by using steady-state and time-resolved fluorescence and intracellularly by using fluorescence-lifetime imaging microscopy (FLIM) in human epithelioid cervix carcinoma (HeLa) cells., (© 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.)

Published
2015
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