1. Use of a composite pedicled muscle flap and rhBMP-7 for mandibular reconstruction
- Author
-
S.R.R. Challa, Edward Odell, S. Creanor, Muammar Abu-Serriah, Ashraf Ayoub, Khursheed F. Moos, and Jeremy McMahon
- Subjects
Replacement ossification ,Bone Regeneration ,Bone Morphogenetic Protein 7 ,Lamellar bone ,Muscle flap ,Mandible ,Bone morphogenetic protein ,Surgical Flaps ,Neck Muscles ,Transforming Growth Factor beta ,Animals ,Medicine ,Mandibular reconstruction ,Sheep ,business.industry ,Cartilage ,Anatomy ,Plastic Surgery Procedures ,medicine.disease ,Microradiography ,Recombinant Proteins ,medicine.anatomical_structure ,Otorhinolaryngology ,Bone Morphogenetic Proteins ,Feasibility Studies ,Surgery ,Oral Surgery ,Gradual increase ,business ,Calcification - Abstract
The aim of this study was to investigate the feasibility of reconstructing critical size continuity osteoperiosteal defects of the mandible using a composite of recombinant BMP-7 contained in a bovine type-1 collagen carrier wrapped in a pedicled sterno-occipitalis muscle flap. At 3 months following surgery, bridging of the surgical defect was noted in three subjects (60%). Histologically, the induced bone regenerate showed maturation from woven to lamellar bone. Islands of cartilage were distributed throughout the defect. Replacement ossification of the degenerated muscle was a common feature in all specimens. Microradiography showed a gradual increase in the calcification of mineralized tissue from the margin to the centre of the newly generated bone. This research represents a proof of the concept that bone can be satisfactorily formed within a muscular scaffolding at the site of the created defect in a one-stage procedure.
- Published
- 2007
- Full Text
- View/download PDF